244:
221:
118:
143:
495:
250:
149:
1414:
and this relocalisation, together with an ELMO-dependent conformational change in Dock180, is sufficient to promote GTP-loading of Rac. RhoG-mediated Rac signalling has been shown to promote neurite outgrowth and cell migration in mammalian cells as well as phagocytosis of apoptotic cells in
1179:. RhoG belongs to the Rac subgroup and emerged as a consequence of retroposition in early vertebrates. RhoG shares a subset of common binding partners with Rac, Cdc42 and RhoU/V members but a major specificity is its inability to bind to CRIB domain proteins such as PAKs.
1265:
which also prevents their activation. The dynamic regulation of G protein signalling is necessarily complex and the 130 or more GEFs, GAPs and GDIs described thus far for the Rho family are considered to be the primary determinants of their spatiotemporal activity.
1367:). The extent to which RhoG regulates these pathways is poorly understood thus far, however, one specific pathway downstream of RhoG has received much attention and is therefore well characterised. This pathway involves RhoG-dependent activation of
2638:
Lu M, Kinchen JM, Rossman KL, Grimsley C, deBakker C, Brugnera E, Tosello-Trampont AC, Haney LB, Klingele D, Sondek J, Hengartner MO, Ravichandran KS (August 2004). "PH domain of ELMO functions in trans to regulate Rac activation via Dock180".
1269:
There are a number of GEFs reported to interact with RhoG, although in some cases the physiological significance of these interactions has yet to be proven. Well characterised examples include the dual specificity GEF
2594:
Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, Tosello-Trampont AC, Macara IG, Madhani H, Fink GR, Ravichandran KS (August 2002). "Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex".
3408:
Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS (October 2001).
2164:
Blangy A, Vignal E, Schmidt S, Debant A, Gauthier-Rouvière C, Fort P (February 2000). "TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG".
2870:
Taviaux SA, Vincent S, Fort P, Demaille JG (June 1993). "Localization of ARHG, a member of the RAS homolog gene family, to 11p15.5-11p15.4 by fluorescence in situ hybridization".
3567:
257:
156:
2300:
deBakker CD, Haney LB, Kinchen JM, Grimsley C, Lu M, Klingele D, Hsu PK, Chou BK, Cheng LC, Blangy A, Sondek J, Hengartner MO, Wu YC, Ravichandran KS (December 2004).
1363:
Activated G proteins are able to couple to multiple downstream effectors and can therefore control a number of distinct signalling pathways (a characteristic known as
3108:
Jankowski A, Zhu P, Marshall JG (September 2008). "Capture of an activated receptor complex from the surface of live cells by affinity receptor chromatography".
2506:"RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG"
1387:
inesis)-family of GEFs. This family is divided into four subfamilies (A-D) and it is subfamilies A and B that are involved in the pathway described here.
1258:
823:
79:
804:
4260:
1391:, the archetypal member of this family, is seen as an atypical GEF in that efficient GEF activity requires the presence of the DOCK-binding protein
3560:
3790:
3303:"Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation"
4447:
3527:
2951:
1534:
3759:
1245:(GEFs) and these facilitate the exchange of GDP for GTP so as to promote subsequent RhoG-mediated signalling. The second class are known as
1516:
1849:"RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration"
2782:
Neudauer CL, Joberty G, Macara IG (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10".
1242:
243:
3553:
3467:
Kunisaki Y, Nishikimi A, Tanaka Y, Takii R, Noda M, Inayoshi A, Watanabe K, Sanematsu F, Sasazuki T, Sasaki T, Fukui Y (August 2006).
3410:
2041:"Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB"
1030:
1023:
1705:
Condliffe AM, Webb LM, Ferguson GJ, Davidson K, Turner M, Vigorito E, Manifava M, Chilvers ER, Stephens LR, Hawkins PT (May 2006).
220:
2129:
Yamaki N, Negishi M, Katoh H (August 2007). "RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism".
1410:. The proposed model for RhoG-dependent Rac activation involves recruitment of the ELMO/Dock180 complex to activated RhoG at the
1261:(GDIs), inhibit dissociation of GDP and thus lock the G protein in its inactive state. GDIs can also sequester G proteins in the
2302:"Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO"
1587:
4350:
1503:
1482:
4345:
142:
117:
1499:
1347:
There have been very few interactions reported between RhoG and negative regulators of G protein function. Examples include
4367:
1478:
4415:
3732:
3379:
Hiramoto K, Negishi M, Katoh H (December 2006). "Dock4 is regulated by RhoG and promotes Rac-dependent cell migration".
2934:
Patel JC, Galán JE (2008). "Investigating the function of Rho family GTPases during
Salmonella/host cell interactions".
59:
4337:
3057:
Lu M, Kinchen JM, Rossman KL, Grimsley C, Hall M, Sondek J, Hengartner MO, Yajnik V, Ravichandran KS (February 2005).
1451:
256:
155:
3346:"The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids"
2682:
Katoh H, Negishi M (July 2003). "RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo".
3182:"Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration"
4396:
3937:
3835:
3660:
3656:
3633:
3606:
3593:
3580:
2242:"The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth"
1246:
249:
148:
1163:. Expression of RhoG in mammals is widespread and studies of its function have been carried out in fibroblasts,
3951:
3646:
3611:
3584:
3411:"CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration"
868:
67:
4321:
4284:
3623:
1552:
Ridley AJ (October 2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking".
1329:
849:
3272:
Le Gallic L, Fort P (May 1997). "Structure of the human ARHG locus encoding the Rho/Rac-like RhoG GTPase".
4051:
3691:
1296:
1234:
1106:
4181:
4089:
2408:"Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2"
2201:"The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo"
1238:
131:
2357:
Ellerbroek SM, Wennerberg K, Arthur WT, Dunty JM, Bowman DR, DeMali KA, Der C, Burridge K (July 2004).
2504:
Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B (November 1996).
1847:
van Buul JD, Allingham MJ, Samson T, Meller J, Boulter E, García-Mata R, Burridge K (September 2007).
3236:
3070:
2691:
2313:
2253:
3137:
Vigorito E, Bell S, Hebeis BJ, Reynolds H, McAdam S, Emson PC, McKenzie A, Turner M (January 2004).
4386:
1325:
1279:
1241:). Three classes of protein interact with RhoG to regulate GTP/GDP loading. The first are known as
1188:
46:
4401:
3967:
3545:
3441:
3260:
3096:
2715:
2664:
2620:
2339:
2279:
1203:
1121:
91:
3059:"A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs"
1274:
which is able to promote nucleotide exchange on RhoG and Rac (via its GEFD1 domain) and also on
1006:
985:
959:
938:
2457:"Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins"
1233:
As with all small G proteins RhoG is able to signal to downstream effectors when bound to GTP (
3641:
3533:
3523:
3498:
3433:
3396:
3367:
3332:
3289:
3252:
3211:
3168:
3125:
3088:
3045:
3010:
2981:"Differential activation and function of Rho GTPases during Salmonella-host cell interactions"
2967:
2947:
2922:
2887:
2848:
2799:
2764:
2707:
2656:
2612:
2576:
2527:
2486:
2437:
2388:
2331:
2271:
2222:
2181:
2146:
2111:
2062:
2021:
1973:
1924:
1878:
1826:
1772:
1728:
1684:
1632:
1569:
1257:
activity of the G protein) thus terminating RhoG-mediated signalling. A third group, known as
1172:
39:
4031:
3977:
3959:
3825:
3815:
3769:
3515:
3488:
3480:
3469:"DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis"
3425:
3388:
3357:
3322:
3314:
3281:
3244:
3201:
3193:
3158:
3150:
3117:
3078:
3035:
3000:
2992:
2957:
2939:
2912:
2879:
2838:
2830:
2791:
2754:
2746:
2699:
2648:
2604:
2566:
2558:
2517:
2476:
2468:
2427:
2419:
2378:
2370:
2321:
2261:
2212:
2173:
2138:
2101:
2093:
2052:
2011:
1963:
1955:
1914:
1868:
1860:
1816:
1808:
1762:
1718:
1674:
1666:
1622:
1614:
1561:
1431:
1321:
336:
267:
211:
166:
3844:
3449:
4378:
4267:
4081:
3781:
3601:
1411:
1152:
494:
311:
87:
3240:
3074:
2695:
2317:
2257:
1278:
via a separate GEF domain (GEFD2). Activation of RhoG by TRIO has been shown to promote
3701:
3493:
3468:
3206:
3181:
3005:
2980:
2962:
2571:
2546:
2432:
2407:
2106:
2081:
1968:
1943:
1873:
1848:
1392:
3519:
3429:
3327:
3302:
3163:
3138:
2943:
2383:
2358:
2266:
2241:
2240:
Estrach S, Schmidt S, Diriong S, Penna A, Blangy A, Fort P, Debant A (February 2002).
1749:
Vigorito E, Billadeu DD, Savoy D, McAdam S, Doody G, Fort P, Turner M (January 2003).
1627:
1602:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
627:
622:
617:
612:
607:
602:
597:
592:
587:
582:
577:
561:
556:
551:
546:
541:
536:
4441:
4245:
3855:
2843:
2834:
2818:
2759:
2750:
2734:
2481:
2456:
1998:
Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (December 2002).
1821:
1812:
1796:
1679:
1654:
1653:
Gauthier-Rouvière C, Vignal E, Mériane M, Roux P, Montcourier P, Fort P (June 1998).
1328:) in fibroblasts and apical cup assembly in endothelial cells (an important stage in
1222:
1192:
1118:
523:
3445:
3318:
3100:
2624:
2283:
71:
4230:
4203:
4132:
4125:
4108:
4103:
4077:
2719:
2343:
1795:
Katoh H, Yasui H, Yamaguchi Y, Aoki J, Fujita H, Mori K, Negishi M (October 2000).
1368:
1287:
1199:
329:
108:
3264:
3154:
2668:
2359:"SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis"
2199:
Bellanger JM, Lazaro JB, Diriong S, Fernandez A, Lamb N, Debant A (January 1998).
1603:"Growth-regulated expression of rhoG, a new member of the ras homolog gene family"
95:
4326:
3392:
2142:
1723:
1706:
1539:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1521:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1423:
1271:
1207:
1160:
1156:
1125:
2547:"GEF what? Dock180 and related proteins help Rac to polarize cells in new ways"
2423:
412:
4311:
4000:
3083:
3058:
2562:
2326:
2301:
1655:"RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs"
1565:
1435:
1407:
1364:
1283:
1250:
1219:
1176:
1164:
1133:
1129:
228:
125:
75:
3121:
2522:
2505:
4017:
3576:
3510:
Lu M, Ravichandran KS (2006). "Dock180–ELMO Cooperation in Rac
Activation".
2819:"Kinectin is a key effector of RhoG microtubule-dependent cellular activity"
2735:"Kinectin is a key effector of RhoG microtubule-dependent cellular activity"
2374:
1959:
1291:
1114:
768:
472:
350:
295:
282:
194:
181:
83:
3537:
3502:
3437:
3400:
3371:
3362:
3345:
3336:
3285:
3215:
3172:
3129:
3092:
3049:
3014:
2971:
2926:
2917:
2900:
2883:
2852:
2817:
Vignal E, Blangy A, Martin M, Gauthier-Rouvière C, Fort P (December 2001).
2803:
2795:
2768:
2733:
Vignal E, Blangy A, Martin M, Gauthier-Rouvière C, Fort P (December 2001).
2711:
2660:
2616:
2580:
2490:
2472:
2392:
2335:
2275:
2217:
2200:
2185:
2150:
2115:
2097:
2066:
2057:
2040:
2025:
2016:
1999:
1977:
1928:
1882:
1830:
1776:
1767:
1750:
1732:
1573:
3484:
3293:
3256:
2996:
2891:
2531:
2441:
2226:
2177:
1864:
1797:"Small GTPase RhoG is a key regulator for neurite outgrowth in PC12 cells"
1751:"RhoG regulates gene expression and the actin cytoskeleton in lymphocytes"
1688:
1636:
1618:
1320:
actor), is thought to be RhoG-specific and has been reported to stimulate
1070:
1065:
2901:"Structural basis for the signaling specificity of RhoG and Rac1 GTPases"
1670:
1168:
1054:
913:
894:
2703:
4422:
4391:
4169:
4164:
3923:
3913:
3888:
3883:
3618:
3197:
2082:"Involvement of the Rho/Rac family member RhoG in caveolar endocytosis"
1388:
1352:
1262:
1215:
1211:
1110:
880:
835:
3225:"Oncogene ect2 is related to regulators of small GTP-binding proteins"
3040:
3023:
1919:
1902:
4299:
3941:
3918:
3908:
3878:
3873:
3868:
3863:
3820:
3810:
3805:
3800:
3795:
3764:
3752:
3747:
3742:
3737:
3725:
3720:
3715:
3664:
3248:
1422:
Other proteins known to bind RhoG in its GTP-bound state include the
1348:
1254:
1038:
790:
3224:
3139:"Immunological function in mice lacking the Rac-related GTPase RhoG"
2652:
2608:
4355:
4294:
4277:
4272:
4120:
4098:
4064:
4059:
4044:
4022:
4010:
4005:
3995:
3990:
3985:
3710:
3686:
1196:
753:
749:
4360:
4316:
4304:
4289:
4255:
4250:
4235:
4218:
4213:
4208:
4196:
4191:
4186:
4176:
4147:
4142:
4137:
4039:
1455:
1439:
1427:
1341:
1337:
1333:
1301:
1275:
1187:
Like most small G proteins RhoG is involved in a diverse set of
1137:
63:
3549:
1944:"Evolution of the Rho family of ras-like GTPases in eukaryotes"
4410:
4406:
1102:
704:
positive regulation of protein localization to plasma membrane
503:
2406:
Schuebel KE, Movilla N, Rosa JL, Bustelo XR (November 1998).
1588:"Entrez Gene: RHOG ras homolog gene family, member G (rho G)"
3223:
Miki T, Smith CL, Long JE, Eva A, Fleming TP (April 1993).
3514:. Methods in Enzymology. Vol. 406. pp. 388–402.
1332:). Other GEFs reported to interact with RhoG include Dbs,
3344:
Skowronek KR, Guo F, Zheng Y, Nassar N (September 2004).
2938:. Methods in Enzymology. Vol. 439. pp. 145–58.
2039:
Murga C, Zohar M, Teramoto H, Gutkind JS (January 2002).
2080:
Prieto-Sánchez RM, Berenjeno IM, Bustelo XR (May 2006).
1648:
1646:
319:
684:
regulation of small GTPase mediated signal transduction
562:
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
3512:
Regulators and
Effectors of Small GTPases: Rho Family
1942:
Boureux A, Vignal E, Faure S, Fort P (January 2007).
1903:"Activation of Rac1 by RhoG regulates cell migration"
484:
664:
positive regulation of cell population proliferation
4376:
4335:
4075:
3949:
3936:
3901:
3853:
3834:
3780:
3700:
3679:
3672:
3655:
3632:
3592:
2784:
999:
978:
952:
931:
734:
phosphatidylinositol phosphate biosynthetic process
654:
positive regulation of transcription, DNA-templated
1993:
1991:
1989:
1987:
1495:
1493:
1491:
1474:
1472:
1470:
739:positive regulation of protein kinase B signaling
266:
165:
2899:Prieto-Sánchez RM, Bustelo XR (September 2003).
2295:
2293:
1842:
1840:
1744:
1742:
1700:
1698:
1901:Katoh H, Hiramoto K, Negishi M (January 2006).
16:Protein-coding gene in the species Homo sapiens
2000:"RhoG signals in parallel with Rac1 and Cdc42"
1500:GRCm38: Ensembl release 89: ENSMUSG00000073982
3561:
3301:Booden MA, Campbell SL, Der CJ (April 2002).
3180:Meller J, Vidali L, Schwartz MA (June 2008).
1896:
1894:
1892:
1790:
1788:
1786:
1707:"RhoG regulates the neutrophil NADPH oxidase"
1191:mechanisms. In mammalian cells these include
729:regulation of actin cytoskeleton organization
719:establishment or maintenance of cell polarity
8:
3022:Meller N, Merlot S, Guda C (November 2005).
709:G protein-coupled receptor signaling pathway
1601:Vincent S, Jeanteur P, Fort P (July 1992).
1479:GRCh38: Ensembl release 89: ENSG00000177105
3946:
3676:
3669:
3568:
3554:
3546:
1259:Guanine nucleotide dissociation inhibitors
1237:) and unable to signal when bound to GDP (
764:
519:
307:
206:
103:
3492:
3361:
3326:
3205:
3162:
3082:
3039:
3004:
2961:
2916:
2842:
2758:
2641:Nature Structural & Molecular Biology
2570:
2521:
2480:
2431:
2382:
2325:
2265:
2216:
2105:
2056:
2015:
1967:
1918:
1872:
1820:
1766:
1722:
1678:
1626:
1117:), and is an important component of many
694:small GTPase mediated signal transduction
50:, ARHG, RhoG, ras homolog family member G
3024:"CZH proteins: a new family of Rho-GEFs"
2455:Movilla N, Bustelo XR (November 1999).
1466:
20:
1330:leukocyte trans-endothelial migration
271:
232:
227:
170:
129:
124:
7:
2979:Patel JC, Galán JE (November 2006).
3350:The Journal of Biological Chemistry
2905:The Journal of Biological Chemistry
2510:The Journal of Biological Chemistry
2004:The Journal of Biological Chemistry
1243:Guanine nucleotide exchange factors
996:
975:
949:
928:
904:
885:
859:
840:
814:
795:
613:intracellular anatomical structure
489:
407:
345:
324:
14:
1253:of GTP to GDP (via the intrinsic
2936:Small GTPases in Disease, Part B
2835:10.1128/MCB.21.23.8022-8034.2001
2751:10.1128/MCB.21.23.8022-8034.2001
2545:Côté JF, Vuori K (August 2007).
1813:10.1128/MCB.20.19.7378-7387.2000
1406:tility) which binds RhoG at its
1308:rc homology 3 domain-containing
493:
255:
248:
242:
219:
154:
147:
141:
116:
3319:10.1128/MCB.22.8.2487-2497.2002
1948:Molecular Biology and Evolution
1151:RhoG was first identified as a
689:actin cytoskeleton organization
679:Rac protein signal transduction
659:Rho protein signal transduction
3307:Molecular and Cellular Biology
3143:Molecular and Cellular Biology
2823:Molecular and Cellular Biology
2739:Molecular and Cellular Biology
2461:Molecular and Cellular Biology
1801:Molecular and Cellular Biology
1607:Molecular and Cellular Biology
1282:-induced neurite outgrowth in
583:endoplasmic reticulum membrane
504:More reference expression data
473:More reference expression data
1:
3520:10.1016/S0076-6879(06)06028-9
3430:10.1016/S0092-8674(01)00520-7
3155:10.1128/MCB.24.2.719-729.2004
2944:10.1016/S0076-6879(07)00411-9
2363:Molecular Biology of the Cell
2267:10.1016/S0960-9822(02)00658-9
1659:Molecular Biology of the Cell
1359:Signalling downstream of RhoG
669:regulation of ruffle assembly
644:activation of GTPase activity
240:
139:
4448:Genes on human chromosome 11
1155:upregulated in hamster lung
4338:Protein-synthesizing GTPase
3473:The Journal of Cell Biology
3393:10.1016/j.yexcr.2006.09.006
2985:The Journal of Cell Biology
2143:10.1016/j.yexcr.2007.05.010
1853:The Journal of Cell Biology
1724:10.4049/jimmunol.176.9.5314
1229:Regulation of RhoG activity
1214:outgrowth, protection from
1195:(through regulation of the
714:actin filament organization
4464:
3381:Experimental Cell Research
2131:Experimental Cell Research
1247:GTPase activating proteins
608:secretory granule membrane
4397:Guanylate-binding protein
3581:acid anhydride hydrolases
3084:10.1016/j.cub.2005.01.050
2563:10.1016/j.tcb.2007.05.001
2327:10.1016/j.cub.2004.12.029
1566:10.1016/j.tcb.2006.08.006
1535:"Mouse PubMed Reference:"
1517:"Human PubMed Reference:"
1249:(GAPs) and these promote
1069:
1064:
1060:
1053:
1037:
1031:Chr 7: 101.89 – 101.91 Mb
1018:
1003:
982:
971:
956:
935:
924:
911:
907:
892:
888:
879:
866:
862:
847:
843:
834:
821:
817:
802:
798:
789:
774:
767:
763:
747:
522:
518:
501:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
3952:Heterotrimeric G protein
3647:Phosphoadenylylsulfatase
3122:10.1016/j.ab.2008.05.047
2523:10.1074/jbc.271.48.30366
2424:10.1093/emboj/17.22.6608
1300:. Another GEF, known as
1124:. It is a member of the
724:regulation of cell shape
699:neutrophil degranulation
3624:Thiamine-triphosphatase
3186:Journal of Cell Science
3110:Analytical Biochemistry
3028:Journal of Cell Science
2375:10.1091/mbc.E04-02-0146
2166:Journal of Cell Science
1907:Journal of Cell Science
1450:RhoG has been shown to
3363:10.1074/jbc.M312677200
3286:10.1006/geno.1997.4703
2918:10.1074/jbc.M301437200
2884:10.1006/geno.1993.1271
2796:10.1006/bbrc.2000.4160
2551:Trends in Cell Biology
2473:10.1128/mcb.19.11.7870
2218:10.1038/sj.onc.1201532
2098:10.1038/sj.onc.1209333
2058:10.1038/sj.onc.1205036
2017:10.1074/jbc.M203816200
1768:10.1038/sj.onc.1206116
1554:Trends in Cell Biology
1235:Guanosine triphosphate
1218:and regulation of the
1159:upon stimulation with
1136:and is encoded by the
1024:Chr 11: 3.83 – 3.84 Mb
557:protein kinase binding
4379:Polymerization motors
4090:Rho family of GTPases
3485:10.1083/jcb.200602142
2997:10.1083/jcb.200605144
2178:10.1242/jcs.113.4.729
1960:10.1093/molbev/msl145
1865:10.1083/jcb.200612053
1711:Journal of Immunology
1619:10.1128/mcb.12.7.3138
1239:Guanosine diphosphate
603:extracellular exosome
439:stroma of bone marrow
132:Chromosome 11 (human)
1671:10.1091/mbc.9.6.1379
1426:-associated protein
1324:(internalisation of
234:Chromosome 7 (mouse)
4387:dynamin superfamily
3241:1993Natur.362..462M
3075:2005CBio...15..371L
2704:10.1038/nature01817
2696:2003Natur.424..461K
2597:Nature Cell Biology
2318:2004CBio...14.2208D
2258:2002CBio...12..307E
1326:extracellular fluid
1189:cellular signalling
1122:signalling pathways
1097:rowth-related) (or
649:platelet activation
3198:10.1242/jcs.025130
3034:(Pt 21): 4937–46.
1312:uanine nucleotide
1204:gene transcription
1101:) is a small (~21
869:ENSMUSG00000073982
637:Biological process
571:Cellular component
537:nucleotide binding
530:Molecular function
427:tibiofemoral joint
4435:
4434:
4431:
4430:
3932:
3931:
3897:
3896:
3642:Adenylylsulfatase
3529:978-0-12-182811-0
3356:(36): 37895–907.
3235:(6419): 462–465.
3192:(Pt 12): 1981–9.
3041:10.1242/jcs.02671
2953:978-0-12-374311-4
1920:10.1242/jcs.02720
1399:ngulfment and cel
1173:endothelial cells
1080:
1079:
1076:
1075:
1049:
1048:
1014:
1013:
993:
992:
967:
966:
946:
945:
920:
919:
901:
900:
875:
874:
856:
855:
830:
829:
811:
810:
759:
758:
514:
513:
510:
509:
479:
478:
466:
465:
404:
403:
393:bone marrow cells
302:
301:
201:
200:
4455:
3947:
3677:
3670:
3570:
3563:
3556:
3547:
3541:
3506:
3496:
3463:
3461:
3460:
3454:
3448:. Archived from
3415:
3404:
3375:
3365:
3340:
3330:
3297:
3268:
3249:10.1038/362462a0
3219:
3209:
3176:
3166:
3133:
3104:
3086:
3053:
3043:
3018:
3008:
2975:
2965:
2930:
2920:
2911:(39): 37916–25.
2895:
2857:
2856:
2846:
2814:
2808:
2807:
2779:
2773:
2772:
2762:
2730:
2724:
2723:
2679:
2673:
2672:
2635:
2629:
2628:
2591:
2585:
2584:
2574:
2542:
2536:
2535:
2525:
2516:(48): 30366–74.
2501:
2495:
2494:
2484:
2452:
2446:
2445:
2435:
2412:The EMBO Journal
2403:
2397:
2396:
2386:
2354:
2348:
2347:
2329:
2297:
2288:
2287:
2269:
2237:
2231:
2230:
2220:
2196:
2190:
2189:
2172:(Pt 4): 729–39.
2161:
2155:
2154:
2126:
2120:
2119:
2109:
2077:
2071:
2070:
2060:
2036:
2030:
2029:
2019:
1995:
1982:
1981:
1971:
1939:
1933:
1932:
1922:
1898:
1887:
1886:
1876:
1844:
1835:
1834:
1824:
1792:
1781:
1780:
1770:
1746:
1737:
1736:
1726:
1702:
1693:
1692:
1682:
1650:
1641:
1640:
1630:
1598:
1592:
1591:
1584:
1578:
1577:
1549:
1543:
1542:
1531:
1525:
1524:
1513:
1507:
1497:
1486:
1476:
1432:Phospholipase D1
1322:macropinocytosis
1062:
1061:
1033:
1026:
1009:
997:
988:
976:
972:RefSeq (protein)
962:
950:
941:
929:
905:
886:
860:
841:
815:
796:
765:
520:
506:
497:
490:
475:
415:
413:Top expressed in
408:
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
96:RHOG - orthologs
49:
42:
21:
4463:
4462:
4458:
4457:
4456:
4454:
4453:
4452:
4438:
4437:
4436:
4427:
4372:
4331:
4082:Ras superfamily
4071:
4055:
4035:
3981:
3971:
3963:
3928:
3893:
3849:
3830:
3776:
3733:Plasma membrane
3696:
3651:
3628:
3602:Pyrophosphatase
3588:
3574:
3544:
3530:
3509:
3466:
3458:
3456:
3452:
3413:
3407:
3387:(20): 4205–16.
3378:
3343:
3300:
3271:
3222:
3179:
3136:
3107:
3063:Current Biology
3056:
3021:
2978:
2954:
2933:
2898:
2869:
2865:
2863:Further reading
2860:
2829:(23): 8022–34.
2816:
2815:
2811:
2781:
2780:
2776:
2745:(23): 8022–34.
2732:
2731:
2727:
2690:(6947): 461–4.
2681:
2680:
2676:
2653:10.1038/nsmb800
2637:
2636:
2632:
2593:
2592:
2588:
2544:
2543:
2539:
2503:
2502:
2498:
2467:(11): 7870–85.
2454:
2453:
2449:
2418:(22): 6608–21.
2405:
2404:
2400:
2356:
2355:
2351:
2312:(24): 2208–16.
2306:Current Biology
2299:
2298:
2291:
2246:Current Biology
2239:
2238:
2234:
2198:
2197:
2193:
2163:
2162:
2158:
2137:(13): 2821–32.
2128:
2127:
2123:
2092:(21): 2961–73.
2079:
2078:
2074:
2038:
2037:
2033:
2010:(49): 47810–7.
1997:
1996:
1985:
1941:
1940:
1936:
1913:(Pt 1): 56–65.
1900:
1899:
1890:
1846:
1845:
1838:
1807:(19): 7378–87.
1794:
1793:
1784:
1748:
1747:
1740:
1704:
1703:
1696:
1652:
1651:
1644:
1600:
1599:
1595:
1586:
1585:
1581:
1551:
1550:
1546:
1533:
1532:
1528:
1515:
1514:
1510:
1498:
1489:
1477:
1468:
1464:
1448:
1412:plasma membrane
1361:
1231:
1185:
1153:coding sequence
1149:
1071:View/Edit Mouse
1066:View/Edit Human
1029:
1022:
1019:Location (UCSC)
1005:
984:
958:
937:
850:ENSG00000177105
743:
674:cell chemotaxis
632:
628:cell projection
598:plasma membrane
566:
552:GTPase activity
547:protein binding
502:
471:
462:
457:
453:
449:
445:
441:
437:
433:
429:
425:
411:
400:
395:
391:
387:
383:
379:
375:
371:
367:
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
4461:
4459:
4451:
4450:
4440:
4439:
4433:
4432:
4429:
4428:
4426:
4425:
4420:
4419:
4418:
4413:
4404:
4399:
4394:
4383:
4381:
4374:
4373:
4371:
4370:
4365:
4364:
4363:
4358:
4353:
4342:
4340:
4333:
4332:
4330:
4329:
4324:
4319:
4314:
4309:
4308:
4307:
4302:
4297:
4292:
4282:
4281:
4280:
4275:
4265:
4264:
4263:
4258:
4253:
4241:
4240:
4239:
4238:
4233:
4223:
4222:
4221:
4216:
4211:
4201:
4200:
4199:
4194:
4189:
4179:
4174:
4173:
4172:
4167:
4157:
4156:
4155:
4150:
4145:
4140:
4130:
4129:
4128:
4123:
4113:
4112:
4111:
4106:
4101:
4086:
4084:
4073:
4072:
4070:
4069:
4068:
4067:
4062:
4053:
4049:
4048:
4047:
4042:
4033:
4029:
4028:
4027:
4026:
4025:
4015:
4014:
4013:
4008:
3998:
3993:
3988:
3979:
3975:
3974:
3973:
3969:
3961:
3956:
3954:
3944:
3934:
3933:
3930:
3929:
3927:
3926:
3921:
3916:
3911:
3905:
3903:
3899:
3898:
3895:
3894:
3892:
3891:
3886:
3881:
3876:
3871:
3866:
3860:
3858:
3851:
3850:
3848:
3847:
3841:
3839:
3832:
3831:
3829:
3828:
3823:
3818:
3813:
3808:
3803:
3798:
3793:
3787:
3785:
3778:
3777:
3775:
3774:
3773:
3772:
3767:
3757:
3756:
3755:
3750:
3745:
3740:
3730:
3729:
3728:
3723:
3718:
3707:
3705:
3698:
3697:
3695:
3694:
3689:
3683:
3681:
3680:Cu++ (3.6.3.4)
3674:
3667:
3653:
3652:
3650:
3649:
3644:
3638:
3636:
3630:
3629:
3627:
3626:
3621:
3616:
3615:
3614:
3609:
3598:
3596:
3590:
3589:
3575:
3573:
3572:
3565:
3558:
3550:
3543:
3542:
3528:
3507:
3464:
3405:
3376:
3341:
3313:(8): 2487–97.
3298:
3269:
3220:
3177:
3134:
3105:
3054:
3019:
2976:
2952:
2931:
2896:
2866:
2864:
2861:
2859:
2858:
2809:
2774:
2725:
2674:
2630:
2609:10.1038/ncb824
2586:
2537:
2496:
2447:
2398:
2369:(7): 3309–19.
2349:
2289:
2232:
2191:
2156:
2121:
2072:
2031:
1983:
1934:
1888:
1859:(7): 1279–93.
1836:
1782:
1738:
1717:(9): 5314–20.
1694:
1665:(6): 1379–94.
1642:
1613:(7): 3138–48.
1593:
1579:
1544:
1526:
1508:
1487:
1465:
1463:
1460:
1447:
1444:
1371:via the DOCK (
1360:
1357:
1230:
1227:
1184:
1181:
1148:
1145:
1078:
1077:
1074:
1073:
1068:
1058:
1057:
1051:
1050:
1047:
1046:
1044:
1042:
1035:
1034:
1027:
1020:
1016:
1015:
1012:
1011:
1001:
1000:
994:
991:
990:
980:
979:
973:
969:
968:
965:
964:
954:
953:
947:
944:
943:
933:
932:
926:
922:
921:
918:
917:
909:
908:
902:
899:
898:
890:
889:
883:
877:
876:
873:
872:
864:
863:
857:
854:
853:
845:
844:
838:
832:
831:
828:
827:
819:
818:
812:
809:
808:
800:
799:
793:
787:
786:
781:
776:
772:
771:
761:
760:
757:
756:
745:
744:
742:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
640:
638:
634:
633:
631:
630:
625:
620:
615:
610:
605:
600:
595:
593:focal adhesion
590:
585:
580:
574:
572:
568:
567:
565:
564:
559:
554:
549:
544:
539:
533:
531:
527:
526:
516:
515:
512:
511:
508:
507:
499:
498:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
459:pyloric antrum
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
389:olfactory bulb
386:
382:
378:
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
4460:
4449:
4446:
4445:
4443:
4424:
4421:
4417:
4414:
4412:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4390:
4389:
4388:
4385:
4384:
4382:
4380:
4375:
4369:
4366:
4362:
4359:
4357:
4354:
4352:
4349:
4348:
4347:
4344:
4343:
4341:
4339:
4334:
4328:
4325:
4323:
4320:
4318:
4315:
4313:
4310:
4306:
4303:
4301:
4298:
4296:
4293:
4291:
4288:
4287:
4286:
4283:
4279:
4276:
4274:
4271:
4270:
4269:
4266:
4262:
4259:
4257:
4254:
4252:
4249:
4248:
4247:
4243:
4242:
4237:
4234:
4232:
4229:
4228:
4227:
4224:
4220:
4217:
4215:
4212:
4210:
4207:
4206:
4205:
4202:
4198:
4195:
4193:
4190:
4188:
4185:
4184:
4183:
4180:
4178:
4175:
4171:
4168:
4166:
4163:
4162:
4161:
4158:
4154:
4151:
4149:
4146:
4144:
4141:
4139:
4136:
4135:
4134:
4131:
4127:
4124:
4122:
4119:
4118:
4117:
4114:
4110:
4107:
4105:
4102:
4100:
4097:
4096:
4095:
4091:
4088:
4087:
4085:
4083:
4079:
4074:
4066:
4063:
4061:
4058:
4057:
4056:
4050:
4046:
4043:
4041:
4038:
4037:
4036:
4030:
4024:
4021:
4020:
4019:
4016:
4012:
4009:
4007:
4004:
4003:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3983:
3982:
3976:
3972:
3966:
3965:
3964:
3958:
3957:
3955:
3953:
3948:
3945:
3943:
3939:
3935:
3925:
3922:
3920:
3917:
3915:
3912:
3910:
3907:
3906:
3904:
3900:
3890:
3887:
3885:
3882:
3880:
3877:
3875:
3872:
3870:
3867:
3865:
3862:
3861:
3859:
3857:
3856:P-type ATPase
3852:
3846:
3843:
3842:
3840:
3837:
3833:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3807:
3804:
3802:
3799:
3797:
3794:
3792:
3789:
3788:
3786:
3783:
3779:
3771:
3768:
3766:
3763:
3762:
3761:
3758:
3754:
3751:
3749:
3746:
3744:
3741:
3739:
3736:
3735:
3734:
3731:
3727:
3724:
3722:
3719:
3717:
3714:
3713:
3712:
3709:
3708:
3706:
3703:
3699:
3693:
3690:
3688:
3685:
3684:
3682:
3678:
3675:
3671:
3668:
3666:
3662:
3658:
3654:
3648:
3645:
3643:
3640:
3639:
3637:
3635:
3631:
3625:
3622:
3620:
3617:
3613:
3610:
3608:
3605:
3604:
3603:
3600:
3599:
3597:
3595:
3591:
3586:
3582:
3578:
3571:
3566:
3564:
3559:
3557:
3552:
3551:
3548:
3539:
3535:
3531:
3525:
3521:
3517:
3513:
3508:
3504:
3500:
3495:
3490:
3486:
3482:
3479:(5): 647–52.
3478:
3474:
3470:
3465:
3455:on 2018-07-19
3451:
3447:
3443:
3439:
3435:
3431:
3427:
3423:
3419:
3412:
3406:
3402:
3398:
3394:
3390:
3386:
3382:
3377:
3373:
3369:
3364:
3359:
3355:
3351:
3347:
3342:
3338:
3334:
3329:
3324:
3320:
3316:
3312:
3308:
3304:
3299:
3295:
3291:
3287:
3283:
3280:(1): 157–60.
3279:
3275:
3270:
3266:
3262:
3258:
3254:
3250:
3246:
3242:
3238:
3234:
3230:
3226:
3221:
3217:
3213:
3208:
3203:
3199:
3195:
3191:
3187:
3183:
3178:
3174:
3170:
3165:
3160:
3156:
3152:
3149:(2): 719–29.
3148:
3144:
3140:
3135:
3131:
3127:
3123:
3119:
3116:(2): 235–48.
3115:
3111:
3106:
3102:
3098:
3094:
3090:
3085:
3080:
3076:
3072:
3068:
3064:
3060:
3055:
3051:
3047:
3042:
3037:
3033:
3029:
3025:
3020:
3016:
3012:
3007:
3002:
2998:
2994:
2991:(3): 453–63.
2990:
2986:
2982:
2977:
2973:
2969:
2964:
2959:
2955:
2949:
2945:
2941:
2937:
2932:
2928:
2924:
2919:
2914:
2910:
2906:
2902:
2897:
2893:
2889:
2885:
2881:
2878:(3): 788–90.
2877:
2873:
2868:
2867:
2862:
2854:
2850:
2845:
2840:
2836:
2832:
2828:
2824:
2820:
2813:
2810:
2805:
2801:
2797:
2793:
2789:
2785:
2778:
2775:
2770:
2766:
2761:
2756:
2752:
2748:
2744:
2740:
2736:
2729:
2726:
2721:
2717:
2713:
2709:
2705:
2701:
2697:
2693:
2689:
2685:
2678:
2675:
2670:
2666:
2662:
2658:
2654:
2650:
2647:(8): 756–62.
2646:
2642:
2634:
2631:
2626:
2622:
2618:
2614:
2610:
2606:
2603:(8): 574–82.
2602:
2598:
2590:
2587:
2582:
2578:
2573:
2568:
2564:
2560:
2557:(8): 383–93.
2556:
2552:
2548:
2541:
2538:
2533:
2529:
2524:
2519:
2515:
2511:
2507:
2500:
2497:
2492:
2488:
2483:
2478:
2474:
2470:
2466:
2462:
2458:
2451:
2448:
2443:
2439:
2434:
2429:
2425:
2421:
2417:
2413:
2409:
2402:
2399:
2394:
2390:
2385:
2380:
2376:
2372:
2368:
2364:
2360:
2353:
2350:
2345:
2341:
2337:
2333:
2328:
2323:
2319:
2315:
2311:
2307:
2303:
2296:
2294:
2290:
2285:
2281:
2277:
2273:
2268:
2263:
2259:
2255:
2252:(4): 307–12.
2251:
2247:
2243:
2236:
2233:
2228:
2224:
2219:
2214:
2211:(2): 147–52.
2210:
2206:
2202:
2195:
2192:
2187:
2183:
2179:
2175:
2171:
2167:
2160:
2157:
2152:
2148:
2144:
2140:
2136:
2132:
2125:
2122:
2117:
2113:
2108:
2103:
2099:
2095:
2091:
2087:
2083:
2076:
2073:
2068:
2064:
2059:
2054:
2051:(2): 207–16.
2050:
2046:
2042:
2035:
2032:
2027:
2023:
2018:
2013:
2009:
2005:
2001:
1994:
1992:
1990:
1988:
1984:
1979:
1975:
1970:
1965:
1961:
1957:
1954:(1): 203–16.
1953:
1949:
1945:
1938:
1935:
1930:
1926:
1921:
1916:
1912:
1908:
1904:
1897:
1895:
1893:
1889:
1884:
1880:
1875:
1870:
1866:
1862:
1858:
1854:
1850:
1843:
1841:
1837:
1832:
1828:
1823:
1818:
1814:
1810:
1806:
1802:
1798:
1791:
1789:
1787:
1783:
1778:
1774:
1769:
1764:
1761:(3): 330–42.
1760:
1756:
1752:
1745:
1743:
1739:
1734:
1730:
1725:
1720:
1716:
1712:
1708:
1701:
1699:
1695:
1690:
1686:
1681:
1676:
1672:
1668:
1664:
1660:
1656:
1649:
1647:
1643:
1638:
1634:
1629:
1624:
1620:
1616:
1612:
1608:
1604:
1597:
1594:
1589:
1583:
1580:
1575:
1571:
1567:
1563:
1560:(10): 522–9.
1559:
1555:
1548:
1545:
1540:
1536:
1530:
1527:
1522:
1518:
1512:
1509:
1505:
1501:
1496:
1494:
1492:
1488:
1484:
1480:
1475:
1473:
1471:
1467:
1461:
1459:
1457:
1453:
1445:
1443:
1441:
1437:
1433:
1429:
1425:
1420:
1418:
1413:
1409:
1405:
1402:
1398:
1394:
1390:
1386:
1382:
1378:
1374:
1370:
1366:
1358:
1356:
1354:
1350:
1345:
1343:
1339:
1335:
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1303:
1299:
1298:
1293:
1289:
1285:
1281:
1277:
1273:
1267:
1264:
1260:
1256:
1252:
1248:
1244:
1240:
1236:
1228:
1226:
1224:
1223:NADPH oxidase
1221:
1217:
1213:
1209:
1205:
1201:
1198:
1194:
1193:cell motility
1190:
1182:
1180:
1178:
1174:
1170:
1166:
1162:
1158:
1154:
1146:
1144:
1142:
1139:
1135:
1131:
1127:
1126:Rac subfamily
1123:
1120:
1119:intracellular
1116:
1112:
1108:
1104:
1100:
1096:
1092:
1088:
1084:
1072:
1067:
1063:
1059:
1056:
1052:
1045:
1043:
1040:
1036:
1032:
1028:
1025:
1021:
1017:
1010:
1008:
1002:
998:
995:
989:
987:
981:
977:
974:
970:
963:
961:
955:
951:
948:
942:
940:
934:
930:
927:
925:RefSeq (mRNA)
923:
916:
915:
910:
906:
903:
897:
896:
891:
887:
884:
882:
878:
871:
870:
865:
861:
858:
852:
851:
846:
842:
839:
837:
833:
826:
825:
820:
816:
813:
807:
806:
801:
797:
794:
792:
788:
785:
782:
780:
777:
773:
770:
766:
762:
755:
751:
746:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
641:
639:
636:
635:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
599:
596:
594:
591:
589:
586:
584:
581:
579:
576:
575:
573:
570:
569:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
4225:
4159:
4152:
4115:
4093:
4078:Small GTPase
3692:Wilson/ATP7B
3687:Menkes/ATP7A
3511:
3476:
3472:
3457:. Retrieved
3450:the original
3424:(1): 27–41.
3421:
3417:
3384:
3380:
3353:
3349:
3310:
3306:
3277:
3273:
3232:
3228:
3189:
3185:
3146:
3142:
3113:
3109:
3069:(4): 371–7.
3066:
3062:
3031:
3027:
2988:
2984:
2935:
2908:
2904:
2875:
2871:
2826:
2822:
2812:
2790:(2): 541–7.
2787:
2783:
2777:
2742:
2738:
2728:
2687:
2683:
2677:
2644:
2640:
2633:
2600:
2596:
2589:
2554:
2550:
2540:
2513:
2509:
2499:
2464:
2460:
2450:
2415:
2411:
2401:
2366:
2362:
2352:
2309:
2305:
2249:
2245:
2235:
2208:
2204:
2194:
2169:
2165:
2159:
2134:
2130:
2124:
2089:
2085:
2075:
2048:
2044:
2034:
2007:
2003:
1951:
1947:
1937:
1910:
1906:
1856:
1852:
1804:
1800:
1758:
1754:
1714:
1710:
1662:
1658:
1610:
1606:
1596:
1582:
1557:
1553:
1547:
1538:
1529:
1520:
1511:
1449:
1446:Interactions
1421:
1416:
1403:
1400:
1396:
1384:
1380:
1376:
1372:
1362:
1346:
1317:
1313:
1309:
1305:
1295:
1288:phagocytosis
1268:
1232:
1200:cytoskeleton
1186:
1150:
1140:
1105:) monomeric
1098:
1094:
1090:
1086:
1082:
1081:
1004:
983:
957:
936:
912:
893:
867:
848:
822:
803:
783:
778:
335:
328:
294:101,905,261
281:101,888,330
55:External IDs
18:
4402:Mitofusin-1
4377:3.6.5.5-6:
4346:Prokaryotic
1424:microtubule
1208:endocytosis
1157:fibroblasts
623:cell cortex
542:GTP binding
435:bone marrow
423:granulocyte
381:bone marrow
361:granulocyte
273:7|7 E2
33:Identifiers
4368:Eukaryotic
4001:Transducin
3838:(3.6.3.10)
3577:Hydrolases
3459:2019-08-18
1506:, May 2017
1485:, May 2017
1462:References
1438:activator
1436:MAP Kinase
1417:C. elegans
1408:N-terminus
1365:pleiotropy
1297:C. elegans
1284:PC12 cells
1251:hydrolysis
1220:neutrophil
1177:HeLa cells
1165:leukocytes
1134:G proteins
1130:Rho family
397:right lung
385:lymph node
377:C1 segment
339:(ortholog)
193:3,840,959
180:3,826,978
76:HomoloGene
4336:3.6.5.3:
4076:3.6.5.2:
4018:Gustducin
3950:3.6.5.1:
3784:(3.6.3.9)
3704:(3.6.3.8)
3607:Inorganic
1375:edicator
1294:cells in
1292:apoptotic
1147:Discovery
1132:of small
1115:G protein
1109:-binding
1007:NP_062512
986:NP_001656
960:NM_019566
939:NM_001665
769:Orthologs
618:cytoplasm
84:GeneCards
4442:Category
3612:Thiamine
3538:16472672
3503:16943182
3446:15232864
3438:11595183
3401:17027967
3372:15199069
3337:11909943
3274:Genomics
3216:18505794
3173:14701744
3130:18601892
3101:14267018
3093:15723800
3050:16254241
3015:17074883
2972:18374162
2927:12805377
2872:Genomics
2853:11689693
2804:11162552
2769:11689693
2712:12879077
2661:15247908
2625:36363774
2617:12134158
2581:17765544
2491:10523675
2393:15133129
2336:15620647
2284:14439106
2276:11864571
2205:Oncogene
2186:10652265
2151:17570359
2116:16568096
2086:Oncogene
2067:11803464
2045:Oncogene
2026:12376551
1978:17035353
1929:16339170
1883:17875742
1831:10982854
1777:12545154
1755:Oncogene
1733:16621998
1574:16949823
1502:–
1481:–
1452:interact
1434:and the
1428:kinectin
1316:xchange
1183:Function
1169:neuronal
1055:Wikidata
748:Sources:
588:membrane
447:yolk sac
369:monocyte
4423:Tubulin
4392:Dynamin
4244:other:
3924:Katanin
3914:Kinesin
3889:ATP13A3
3884:ATP13A2
3619:Apyrase
3494:2064308
3294:9177787
3257:8464478
3237:Bibcode
3207:2759683
3071:Bibcode
3006:2064522
2963:2677710
2892:8325658
2720:4411133
2692:Bibcode
2572:2887429
2532:8939998
2442:9822605
2433:1171007
2344:1269946
2314:Bibcode
2254:Bibcode
2227:9464532
2107:1463992
1969:2665304
1874:2064659
1689:9614181
1637:1620121
1504:Ensembl
1483:Ensembl
1389:Dock180
1353:RhoGDI3
1263:cytosol
1216:anoikis
1212:neurite
1171:cells,
1128:of the
1111:protein
1093:mology
881:UniProt
836:Ensembl
775:Species
754:QuickGO
578:cytosol
314:pattern
172:11p15.4
72:1928370
40:Aliases
4300:ARL13B
4160:RhoBTB
4054:α12/13
3942:GTPase
3919:Myosin
3909:Dynein
3879:ATP12A
3874:ATP11B
3869:ATP10A
3864:ATP8B1
3854:Other
3826:ATP1B4
3821:ATP1B3
3816:ATP1B2
3811:ATP1B1
3806:ATP1A4
3801:ATP1A3
3796:ATP1A2
3791:ATP1A1
3782:Na+/K+
3770:ATP2C2
3765:ATP2C1
3753:ATP2B4
3748:ATP2B3
3743:ATP2B2
3738:ATP2B1
3726:ATP2A3
3721:ATP2A2
3716:ATP2A1
3665:ATPase
3536:
3526:
3501:
3491:
3444:
3436:
3399:
3370:
3335:
3328:133724
3325:
3292:
3265:722736
3263:
3255:
3229:Nature
3214:
3204:
3171:
3164:343784
3161:
3128:
3099:
3091:
3048:
3013:
3003:
2970:
2960:
2950:
2925:
2890:
2851:
2841:
2802:
2767:
2757:
2718:
2710:
2684:Nature
2669:125990
2667:
2659:
2623:
2615:
2579:
2569:
2530:
2489:
2479:
2440:
2430:
2391:
2384:452585
2381:
2342:
2334:
2282:
2274:
2225:
2184:
2149:
2114:
2104:
2065:
2024:
1976:
1966:
1927:
1881:
1871:
1829:
1819:
1775:
1731:
1687:
1677:
1635:
1628:364528
1625:
1572:
1349:IQGAP2
1255:GTPase
1041:search
1039:PubMed
914:P84096
895:P84095
791:Entrez
485:BioGPS
455:spleen
443:thymus
373:spleen
64:179505
4356:EF-Tu
4295:SAR1B
4278:RAB27
4273:RAB23
4226:RhoDF
4116:RhoUV
4099:CDC42
4094:Cdc42
4080:>
4065:GNA13
4060:GNA12
4045:GNA11
4034:αq/11
4023:GNAT3
4011:GNAT2
4006:GNAT1
3996:GNAI3
3991:GNAI2
3986:GNAI1
3938:3.6.5
3902:3.6.4
3845:ATP4A
3836:H+/K+
3711:SERCA
3673:3.6.3
3657:3.6.3
3634:3.6.2
3594:3.6.1
3453:(PDF)
3442:S2CID
3414:(PDF)
3261:S2CID
3097:S2CID
2844:99969
2760:99969
2716:S2CID
2665:S2CID
2621:S2CID
2482:84867
2340:S2CID
2280:S2CID
1822:86291
1680:25357
1454:with
1197:actin
1161:serum
824:56212
784:Mouse
779:Human
750:Amigo
451:blood
365:blood
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
80:68196
4416:OPA1
4409:and
4361:EF-G
4351:IF-2
4317:Rheb
4305:ARL6
4290:ARF6
4261:NRAS
4256:KRAS
4251:HRAS
4236:RhoD
4231:RhoF
4177:RhoH
4153:RhoG
4138:Rac1
4126:RhoV
4121:RhoU
4104:TC10
4040:GNAQ
3760:SPCA
3587:3.6)
3534:PMID
3524:ISBN
3499:PMID
3434:PMID
3418:Cell
3397:PMID
3368:PMID
3333:PMID
3290:PMID
3253:PMID
3212:PMID
3169:PMID
3126:PMID
3089:PMID
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