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is not mutated in cancer, showing that mutant forms of B-RAF can activate C-RAF through a novel mechanism, establishing a new paradigm of RAF signaling. He is now translating these studies to the clinic by leading a large effort to design and synthesize new anti-B-RAF drugs that will be used to treat
408:
at Cancer
Research UK and has made important contributions to the understanding of cell signalling pathways, particularly in cancer. He was amongst the first to show that mitogen activated protein kinases regulate gene expression by directly
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314:. He translated his basic research discoveries into clinical implementation, improving patient outcomes, elucidating mechanisms of
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440:, he solved the crystal structure of B-RAF and explained how it is activated by mutations that occur in cancer. He elucidated why
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35:
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to monitor therapy responses and optimise patient treatment. His research also highlights the importance of combining
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family, where he discovered that individual RAF proteins are regulated differentially and shown how they respond to
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1311:
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872:
Gray-Schopfer, Vanessa; Wellbrock, Claudia; Marais, Richard (2007). "Melanoma biology and new targeted therapy".
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59:
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in a third of all human tumours. He was a key member of the team that demonstrated that B-RAF is encoded by an
368:
University of
Manchester launched in 2019 an investigation into research misconduct from the Marais laboratory
239:
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in 1985. He completed his postgraduate study at the Ludwig
Institute for Cancer Research and was awarded a
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One or more of the preceding sentences incorporates text from the royalsociety.org website where:
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545:“All text published under the heading 'Biography' on Fellow profile pages is available under
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646:"Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF"
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848:"Cancer Research UK Manchester Institute > Our Research > Molecular Oncology"
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432:, which is a culprit in most human melanomas. He went on to validate B-RAF as a
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380:(AACR) Team Science Award in 2012 for cancer drug discoveries. He received the
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322:. His research informs innovative clinical trial designs with signal-seeking
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361:(ICR), after which Marais set up his own laboratory in 1998 before moving to
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in order to deliver better treatment strategies for patients. His studies on
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with other sun avoidance strategies to reduce population melanoma risk.
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Davies, Helen; Bignell, Graham R.; Cox, Charles; et al. (2002).
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Wan, Paul T.C; Garnett, Mathew J; Roe, S.Mark; et al. (2004).
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Fellows of the
Academy of Medical Sciences (United Kingdom)
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Members of the
European Molecular Biology Organization
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Creative
Commons Attribution 4.0 International License
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400:(FMedSci) in 2008. His citation on election reads:
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306:significantly advanced understanding of melanoma
718:Comparative studies on protein kinase C isotypes
416:. However his greatest impact has been with the
318:and developing new drugs against BRAF and other
159:Comparative studies on protein kinase C isotypes
543:
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388:(SMR) in 2017. He was elected a member of the
290:Marais's research investigates the biology of
1044:
8:
966:: CS1 maint: multiple names: authors list (
576:"Mutations of the BRAF gene in human cancer"
551:Royal Society Terms, conditions and policies
226:a British researcher who is Director of the
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18:
1464:Academics of the University of Manchester
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404:Richard Marais is Professor of Molecular
398:Fellow of the Academy of Medical Sciences
345:(ICRF) in London, where he worked on the
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378:American Association for Cancer Research
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476:"Find people in the EMBO Communities"
449:Marais was awarded membership of the
376:With colleagues, Marais received the
7:
785:Pigment Cell & Melanoma Research
1469:Alumni of University College London
943:"Academy of Europe: Marais Richard"
353:. This was followed by a period in
14:
1474:Alumni of Imperial College London
992:from the original on 28 June 2019
1422: This article incorporates
1417:
941:Hoffmann, Ilire Hasani, Robert.
923:
799:10.1111/j.1755-148X.2010.00708.x
756:
715:Marais, Richard Malcolm (1989).
695:
626:
230:(CRUK) Manchester Institute and
982:"Research misconduct statement"
333:Marais started his career as a
526:"Professor Richard Marais FRS"
1:
665:10.1016/s0092-8674(04)00215-6
386:Society for Melanoma Research
343:Imperial Cancer Research Fund
1454:Fellows of the Royal Society
359:Institute of Cancer Research
282:supervised by Peter Parker.
180:Other academic advisors
143:Institute of Cancer Research
394:Fellow of the Royal Society
1500:
1345:(Baron Willetts of Havant)
557: (archived 2016-11-11)
252:University College London
193:
92:
60:University College London
43:
1015:"Richard Marais FMedSdi"
436:. In collaboration with
270:in 1989 for research on
240:University of Manchester
138:University of Manchester
335:postdoctoral researcher
254:where he was awarded a
250:Marais was educated at
64:Imperial College London
778:Larue, Lionel (2010).
559:
536:. 2018. Archived from
447:
382:Leopold Griffuel Prize
224:Richard Malcolm Marais
83:Leopold Griffuel Prize
23:Richard Malcolm Marais
852:cruk.manchester.ac.uk
836:Europe PubMed Central
414:transcription factors
396:(FRS) in 2018, and a
357:’s laboratory at the
1426:available under the
986:www.manchester.ac.uk
727:University of London
1242:Lalita Ramakrishnan
1202:Dominic Kwiatkowski
894:10.1038/nature05661
886:2007Natur.445..851G
597:10.1038/nature00766
286:Career and research
256:Bachelor of Science
215:/Molecular-Oncology
1484:Molecular oncology
1479:Cancer researchers
1317:Geordie Williamson
1112:Vincenzo Cerundolo
834:publications from
751:uk.bl.ethos.717709
434:therapeutic target
392:(EMBO) in 2009, a
372:Awards and honours
236:Molecular Oncology
228:Cancer Research UK
133:Cancer Research UK
1413:
1412:
1142:Gregory Edgecombe
880:(7130): 851–857.
591:(6892): 949–954.
451:Academia Europaea
221:
220:
94:Scientific career
16:Cancer researcher
1491:
1421:
1385:Albrecht Hofmann
1380:Fabiola Gianotti
1375:Jeffrey Friedman
1370:Sebsebe Demissew
1360:Carolyn Bertozzi
1327:Nikolay Zheludev
1272:Michelle Simmons
1257:David Richardson
1227:Vassilis Pachnis
1197:Dimitri Kullmann
1097:Margaret Brimble
1092:Jillian Banfield
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780:"Richard Marais"
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339:Richard Treisman
276:protein kinase C
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184:Richard Treisman
171:Doctoral advisor
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38:
19:
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1302:Charles Swanton
1292:Graeme Stephens
1282:Timothy Softley
1267:Ingrid Scheffer
1252:Graham Richards
1122:Robert Crabtree
1102:Neil Brockdorff
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555:Wayback Machine
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480:People.embo.org
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453:(MAE) in 2015.
411:phosphorylating
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316:drug resistance
304:cell signalling
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117:Cell signalling
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56:Alma mater
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1365:Martin Chalfie
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1343:David Willetts
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1237:Colin Prentice
1234:
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1219:
1214:
1209:
1207:Richard Marais
1204:
1199:
1194:
1189:
1187:Sophien Kamoun
1184:
1179:
1177:Graeme Jameson
1174:
1169:
1167:Demis Hassabis
1164:
1162:Gregory Hannon
1159:
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1119:
1117:Kevin Costello
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1082:Jim Al-Khalili
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1024:
1019:acmedsci.ac.uk
1003:
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864:
839:
832:Richard Marais
821:
763:
725:(PhD thesis).
702:
658:(6): 855–867.
633:
561:
540:on 2018-05-21.
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461:
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455:
373:
370:
355:Chris Marshall
320:cancer targets
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188:Chris Marshall
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50:Marais in 2018
49:
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15:
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1444:Living people
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1297:Angela Strank
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1287:John Speakman
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1222:Peter O'Hearn
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1212:Cathie Martin
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1137:Richard Dixon
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438:David Barford
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213:/Our-Research
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29:
20:
1416:
1415:
1262:Sheila Rowan
1232:Tracy Palmer
1206:
1182:Harren Jhoti
1157:Robin Grimes
1127:Philip Dawid
1107:Frank Caruso
1087:Polly Arnold
1018:
994:. Retrieved
985:
976:
950:. Retrieved
946:
877:
873:
867:
855:. Retrieved
851:
842:
789:
783:
723:london.ac.uk
722:
717:
655:
649:
588:
582:
544:
538:the original
529:
483:. Retrieved
479:
448:
403:
375:
367:
332:
289:
264:Microbiology
249:
223:
222:
175:Peter Parker
157:
126:Institutions
93:
1322:Daniel Wise
1192:Andrew King
1152:Roger Goody
1132:Peter Dayan
947:Ae-info.org
424:, which is
207:.manchester
77:EMBO Member
1438:Categories
1405:Adi Shamir
1247:Nancy Reid
1172:Judy Hirst
1147:Wenfei Fan
996:12 January
792:(3): 448.
532:. London:
457:References
418:RAF kinase
363:Manchester
324:biomarkers
294:and other
258:degree in
1428:CC BY 4.0
1277:John Smol
1217:Elon Musk
902:1476-4687
808:1755-1471
743:940321860
674:0092-8674
605:0028-0836
445:melanoma.
365:in 2012.
349:known as
328:sunscreen
312:aetiology
246:Education
232:Professor
1430:license.
1336:Honorary
1066:elected
990:Archived
962:cite web
910:17314971
816:20518862
682:15035987
613:12068308
430:oncogene
406:Oncology
347:oncogene
292:melanoma
272:isotypes
260:Genetics
112:Melanoma
1353:Foreign
1075:Fellows
1068:in 2018
1062:of the
1060:Fellows
918:4421616
882:Bibcode
621:3071547
553:at the
426:mutated
341:at the
308:biology
296:cancers
274:of the
238:at the
198:Website
32:FMedSci
952:26 May
916:
908:
900:
874:Nature
857:26 May
814:
806:
749:
741:
690:126161
688:
680:
672:
619:
611:
603:
584:Nature
485:26 May
280:enzyme
278:(PKC)
164:(1989)
162:
153:Thesis
107:Cancer
100:Fields
85:(2017)
79:(2009)
70:Awards
914:S2CID
747:EThOS
686:S2CID
617:S2CID
579:(PDF)
549:.” --
442:C-RAF
351:c-Fos
337:with
300:B-RAF
205:.cruk
34:
30:
1424:text
998:2022
968:link
954:2018
906:PMID
898:ISSN
859:2018
812:PMID
804:ISSN
739:OCLC
678:PMID
670:ISSN
651:Cell
609:PMID
601:ISSN
487:2018
310:and
302:and
262:and
890:doi
878:445
794:doi
731:hdl
660:doi
656:116
593:doi
589:417
422:RAS
268:PhD
234:of
211:.uk
209:.ac
203:www
36:MAE
28:FRS
1440::
1017:.
1006:^
988:.
984:.
964:}}
960:{{
945:.
933:^
912:.
904:.
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