Knowledge (XXG)

Risedronic acid

Source ๐Ÿ“

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rejected P&G's attempted injunction. P&G was criticized for attempting to "preserve its market share by denigrating Boniva". Judge Crotty wrote that "Roche was clearly entitled to respond with its own data, provided that the data was truthfully and accurately presented".
940:. The manufacturers of Boniva, a rival bisphosphonate, were accused in the suit of causing a "serious public health risk" through misrepresentation of scientific findings. In a ruling on September 7, 2006, U.S. District Judge 1216: 184: 1525: 139: 686: 1500: 1209: 1071: 1202: 908:
under the trade names Actonel, Atelvia, and Benet. It is also available in a preparation that includes a calcium carbonate supplement, as Actonel with Calcium.
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In 2006, P&G faced controversy over its handling of clinical research involving risedronate (News Reports and discussion).
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InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
357: 473: 261: 1183: 917: 723: 528: 312: 132: 1370: 1171: 1065: 99: 494: 1425: 1053: 1043: 1018: 1012: 929: 484: 210: 197: 41: 1194: 568: 321: 223: 426: 1520: 1479: 1332: 1307: 1287: 1277: 1272: 1267: 1262: 1257: 1252: 937: 933: 897: 809: 791: 781: 771: 761: 406: 251: 231: 61: 555: 532: 1302: 1297: 1239: 952: 941: 921: 901: 751: 711: 1489: 1430: 544: 1435: 1230: 1226: 715: 152: 147: 1146: 346: 1408: 1400: 1353: 835: 20: 714:. It slows down the cells which break down bone. It's used to treat or prevent 1442: 1415: 1393: 925: 604: 397: 1057: 1452: 1385: 274: 55: 1247: 377: 83: 386: 28: 1447: 332: 955:
drugs, risedronate appears to be associated with the rare side effect
464: 279: 959:, often preceded by dental procedures inducing trauma to the bone. 453: 446: 1378: 627: 618: 500: 437: 191: 1198: 204: 78: 829: 729:
It was patented in 1984 and approved for medical use in 1998.
517: 303:(1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonic acid 178: 110: 693: 1463: 1341: 1318: 1238: 1107:"Boniva advertising 'not misleading' says US judge" 980: 978: 976: 974: 972: 616: 603: 567: 562: 543: 511: 483: 463: 436: 416: 396: 376: 365: 356: 331: 311: 286: 273: 260: 250: 240: 230: 222: 168: 163: 138: 124: 98: 68: 50: 40: 35: 986:"Actonel- risedronate sodium tablet, film coated" 1526:Drugs developed by Takeda Pharmaceutical Company 345: 320: 928:false claims lawsuit against rival drugmakers 1210: 8: 87: 19: 864:. Unsourced material may be challenged and 215:In general: โ„ž (Prescription only) 1501:Farnesyl pyrophosphate synthase inhibitors 1217: 1203: 1195: 1070:: CS1 maint: location missing publisher ( 554: 531: 405: 884:Learn how and when to remove this message 425: 736: 1470: 968: 667: 647: 527: 385: 300: 1063: 1017:. John Wiley & Sons. p. 523. 545: 18: 493: 472: 60: 7: 1190:. U.S. National Library of Medicine. 1178:. U.S. National Library of Medicine. 1149:. Scientific-misconduct.blogspot.com 862:adding citations to reliable sources 499: 151: 1423:Parathyroid hormone-related protein 452: 445: 336: 1040:Essentials of medical pharmacology 594: 14: 1038:Tripathi KD (30 September 2013). 936:claiming false advertising about 650:OC(Cc1cccnc1)(P(=O)(O)O)P(=O)(O)O 1473: 834: 706:, often used as its sodium salt 585: 579: 27: 1042:(Seventh ed.). New Delhi. 1011:Fischer J, Ganellin CR (2006). 896:It is produced and marketed by 675:Key:IIDJRNMFWXDHID-UHFFFAOYSA-N 46:Actonel, Atelvia, Benet, others 588: 573: 1: 1014:Analogue-based Drug Discovery 1147:"Scientific Misconduct Blog" 1125:"Actonel Case Media Reports" 1320:Bone morphogenetic proteins 1542: 1129:Scientific Misconduct Wiki 920:and its marketing partner 563:Chemical and physical data 1516:Drugs developed by AbbVie 1086:"P&G Press statement" 683: 658: 638: 291: 26: 957:osteonecrosis of the jaw 1361:Aluminium chlorohydrate 1225:Drugs for treatment of 1188:Drug Information Portal 1176:Drug Information Portal 720:Paget's disease of bone 1366:Dual action bone agent 951:In common with other 1506:Procter & Gamble 1349:Resorption inhibitor 1184:"Risedronate sodium" 858:improve this section 1511:3-Pyridyl compounds 1135:on 2 February 2009. 1113:. 8 September 2006. 821:Society and culture 739: 200:(Prescription only) 187:(Prescription only) 23: 1371:Strontium ranelate 904:, and in Japan by 737: 708:risedronate sodium 1461: 1460: 1172:"Risedronic acid" 992:. 1 November 2019 894: 893: 886: 818: 817: 746:Relative potency 738:Relative potency 701: 700: 629:Interactive image 513:CompTox Dashboard 208: 195: 182: 114: 81: 16:Chemical compound 1533: 1478: 1477: 1476: 1469: 1294:Non-nitrogenous 1219: 1212: 1205: 1196: 1191: 1179: 1158: 1157: 1155: 1154: 1143: 1137: 1136: 1131:. Archived from 1121: 1115: 1114: 1103: 1097: 1096: 1094: 1093: 1082: 1076: 1075: 1069: 1061: 1035: 1029: 1028: 1008: 1002: 1001: 999: 997: 982: 916:In January 2006 889: 882: 878: 875: 869: 838: 830: 740: 697: 696: 689: 631: 611: 596: 590: 587: 581: 575: 558: 547: 536: 535: 521: 519: 503: 497: 476: 456: 449: 429: 409: 389: 369: 349: 339: 338: 324: 265: 206: 203: 193: 190: 180: 177: 155: 112: 109: 91: 80: 77: 64: 31: 24: 22: 1541: 1540: 1536: 1535: 1534: 1532: 1531: 1530: 1496:Bisphosphonates 1486: 1485: 1484: 1474: 1472: 1464: 1462: 1457: 1337: 1333:Eptotermin alfa 1328:Dibotermin alfa 1314: 1308:Tiludronic acid 1288:Zoledronic acid 1283:Risedronic acid 1278:Pamidronic acid 1273:Neridronic acid 1268:Minodronic acid 1263:Incadronic acid 1258:Ibandronic acid 1253:Alendronic acid 1240:Bisphosphonates 1234: 1223: 1182: 1170: 1167: 1162: 1161: 1152: 1150: 1145: 1144: 1140: 1123: 1122: 1118: 1105: 1104: 1100: 1091: 1089: 1084: 1083: 1079: 1062: 1050: 1037: 1036: 1032: 1025: 1010: 1009: 1005: 995: 993: 984: 983: 970: 965: 934:GlaxoSmithKline 914: 898:Warner Chilcott 890: 879: 873: 870: 855: 839: 828: 823: 743:Bisphosphonate 735: 704:Risedronic acid 692: 690: 687:(what is this?) 684: 679: 676: 671: 666: 665: 654: 651: 646: 645: 634: 609: 599: 593: 584: 578: 539: 515: 507: 479: 459: 432: 412: 392: 372: 352: 335: 327: 307: 304: 299: 298: 263: 242:Protein binding 232:Bioavailability 224:Pharmacokinetic 218: 159: 127: 120: 101: 94: 21:Risedronic acid 17: 12: 11: 5: 1539: 1537: 1529: 1528: 1523: 1518: 1513: 1508: 1503: 1498: 1488: 1487: 1483: 1482: 1459: 1458: 1456: 1455: 1450: 1445: 1440: 1439: 1438: 1433: 1420: 1419: 1418: 1405: 1404: 1403: 1390: 1389: 1388: 1375: 1374: 1373: 1363: 1358: 1357: 1356: 1345: 1343: 1339: 1338: 1336: 1335: 1330: 1324: 1322: 1316: 1315: 1313: 1312: 1311: 1310: 1305: 1303:Clodronic acid 1300: 1298:Etidronic acid 1292: 1291: 1290: 1285: 1280: 1275: 1270: 1265: 1260: 1255: 1244: 1242: 1236: 1235: 1224: 1222: 1221: 1214: 1207: 1199: 1193: 1192: 1180: 1166: 1165:External links 1163: 1160: 1159: 1138: 1116: 1098: 1077: 1048: 1030: 1023: 1003: 967: 966: 964: 961: 953:bisphosphonate 942:Paul A. Crotty 922:Sanofi-Aventis 913: 910: 902:Sanofi-Aventis 892: 891: 874:September 2023 842: 840: 833: 827: 824: 822: 819: 816: 815: 812: 806: 805: 802: 798: 797: 794: 788: 787: 784: 778: 777: 774: 768: 767: 764: 758: 757: 754: 748: 747: 744: 734: 731: 722:. It is taken 712:bisphosphonate 699: 698: 681: 680: 678: 677: 674: 672: 669: 661: 660: 659: 656: 655: 653: 652: 649: 641: 640: 639: 636: 635: 633: 632: 624: 622: 614: 613: 607: 601: 600: 597: 591: 582: 576: 571: 565: 564: 560: 559: 549: 541: 540: 538: 537: 524: 522: 509: 508: 506: 505: 489: 487: 481: 480: 478: 477: 469: 467: 461: 460: 458: 457: 450: 442: 440: 434: 433: 431: 430: 422: 420: 414: 413: 411: 410: 402: 400: 394: 393: 391: 390: 382: 380: 374: 373: 371: 370: 362: 360: 354: 353: 351: 350: 342: 340: 329: 328: 326: 325: 317: 315: 309: 308: 306: 305: 302: 294: 293: 292: 289: 288: 284: 283: 277: 271: 270: 267: 258: 257: 254: 248: 247: 244: 238: 237: 234: 228: 227: 220: 219: 217: 216: 213: 201: 188: 174: 172: 166: 165: 161: 160: 158: 157: 144: 142: 136: 135: 130: 128:administration 122: 121: 119: 118: 116: 106: 104: 96: 95: 93: 92: 74: 72: 66: 65: 58: 48: 47: 44: 38: 37: 33: 32: 15: 13: 10: 9: 6: 4: 3: 2: 1538: 1527: 1524: 1522: 1519: 1517: 1514: 1512: 1509: 1507: 1504: 1502: 1499: 1497: 1494: 1493: 1491: 1481: 1471: 1467: 1454: 1451: 1449: 1446: 1444: 1441: 1437: 1434: 1432: 1431:Abaloparatide 1429: 1428: 1427: 1424: 1421: 1417: 1414: 1413: 1412: 1410: 1406: 1402: 1399: 1398: 1397: 1395: 1391: 1387: 1384: 1383: 1382: 1380: 1376: 1372: 1369: 1368: 1367: 1364: 1362: 1359: 1355: 1352: 1351: 1350: 1347: 1346: 1344: 1340: 1334: 1331: 1329: 1326: 1325: 1323: 1321: 1317: 1309: 1306: 1304: 1301: 1299: 1296: 1295: 1293: 1289: 1286: 1284: 1281: 1279: 1276: 1274: 1271: 1269: 1266: 1264: 1261: 1259: 1256: 1254: 1251: 1250: 1249: 1246: 1245: 1243: 1241: 1237: 1232: 1228: 1227:bone diseases 1220: 1215: 1213: 1208: 1206: 1201: 1200: 1197: 1189: 1185: 1181: 1177: 1173: 1169: 1168: 1164: 1148: 1142: 1139: 1134: 1130: 1126: 1120: 1117: 1112: 1108: 1102: 1099: 1087: 1081: 1078: 1073: 1067: 1059: 1055: 1051: 1049:9789350259375 1045: 1041: 1034: 1031: 1026: 1024:9783527607495 1020: 1016: 1015: 1007: 1004: 991: 987: 981: 979: 977: 975: 973: 969: 962: 960: 958: 954: 949: 946: 943: 939: 935: 931: 927: 923: 919: 912:Controversies 911: 909: 907: 903: 899: 888: 885: 877: 867: 863: 859: 853: 852: 848: 843:This section 841: 837: 832: 831: 825: 820: 813: 811: 808: 807: 803: 800: 799: 795: 793: 790: 789: 785: 783: 780: 779: 775: 773: 770: 769: 765: 763: 760: 759: 755: 753: 750: 749: 745: 742: 741: 732: 730: 727: 725: 721: 717: 713: 709: 705: 695: 688: 682: 673: 668: 664: 657: 648: 644: 637: 630: 626: 625: 623: 620: 615: 608: 606: 602: 572: 570: 566: 561: 557: 553: 550: 548: 546:ECHA InfoCard 542: 534: 530: 529:DTXSID2023563 526: 525: 523: 514: 510: 502: 501:RCSB PDB 496: 491: 490: 488: 486: 482: 475: 471: 470: 468: 466: 462: 455: 451: 448: 444: 443: 441: 439: 435: 428: 424: 423: 421: 419: 415: 408: 404: 403: 401: 399: 395: 388: 384: 383: 381: 379: 375: 368: 364: 363: 361: 359: 355: 348: 344: 343: 341: 334: 330: 323: 319: 318: 316: 314: 310: 301: 297: 290: 285: 281: 278: 276: 272: 268: 266: 259: 255: 253: 249: 245: 243: 239: 235: 233: 229: 225: 221: 214: 212: 202: 199: 189: 186: 176: 175: 173: 171: 167: 162: 154: 149: 146: 145: 143: 141: 137: 134: 131: 129: 123: 117: 108: 107: 105: 103: 97: 90: 85: 76: 75: 73: 71: 67: 63: 59: 57: 53: 49: 45: 43: 39: 36:Clinical data 34: 30: 25: 1436:Teriparatide 1407: 1392: 1377: 1365: 1348: 1282: 1187: 1175: 1151:. Retrieved 1141: 1133:the original 1128: 1119: 1111:Pharma Times 1110: 1101: 1090:. Retrieved 1080: 1039: 1033: 1013: 1006: 994:. Retrieved 989: 950: 947: 915: 895: 880: 871: 856:Please help 844: 801:Risedronate 733:Pharmacology 728: 718:, and treat 716:osteoporosis 707: 703: 702: 691:   685:   262:Elimination 170:Legal status 164:Legal status 70:License data 1409:Cathepsin K 1401:Romosozumab 1354:Ipriflavone 1248:Nitrogenous 1088:. Uk.pg.com 826:Brand names 810:Zoledronate 792:Ibandronate 782:Alendronate 772:Pamidronate 762:Tiludronate 612: gยทmol 552:100.116.436 322:105462-24-6 287:Identifiers 42:Trade names 1490:Categories 1443:Calcitonin 1416:Odanacatib 1394:Sclerostin 1153:2013-03-01 1092:2013-03-01 963:References 926:Lanham Act 752:Etidronate 617:3D model ( 605:Molar mass 485:PDB ligand 427:KM2Z91756Z 398:ChemSpider 358:IUPHAR/BPS 313:CAS Number 296:IUPAC name 252:Metabolism 89:Risedronic 1453:Vitamin D 1426:analogues 1411:inhibitor 1396:inhibitor 1386:Denosumab 1381:inhibitor 1066:cite book 1058:868299888 845:does not 796:500-1000 474:ChEMBL923 282:and fecal 275:Excretion 264:half-life 126:Routes of 100:Pregnancy 62:Monograph 56:Drugs.com 1480:Medicine 990:DailyMed 924:filed a 786:100-500 724:by mouth 694:(verify) 378:DrugBank 140:ATC code 133:By mouth 115: B3 102:category 84:DailyMed 1448:Calcium 996:28 June 918:P&G 866:removed 851:sources 710:, is a 610:283.113 569:Formula 387:DB00884 333:PubChem 156:) 150: ( 148:M05BA07 86::  1521:Sanofi 1466:Portal 1056:  1046:  1021:  938:Boniva 906:Takeda 643:SMILES 465:ChEMBL 454:D03234 447:D00942 280:Kidney 211:โ„ž-only 209: 196: 183: 82:  1379:RANKL 1342:Other 930:Roche 814:5000 804:1000 663:InChI 619:JSmol 492:RIS ( 269:1.5 h 236:0.63% 1072:link 1054:OCLC 1044:ISBN 1019:ISBN 998:2022 932:and 849:any 847:cite 776:100 495:PDBe 438:KEGG 418:UNII 407:5055 367:3176 347:5245 256:None 246:~24% 226:data 52:AHFS 1231:M05 860:by 766:10 518:EPA 337:CID 198:POM 153:WHO 1492:: 1186:. 1174:. 1127:. 1109:. 1068:}} 1064:{{ 1052:. 988:. 971:^ 900:, 756:1 726:. 583:11 498:, 205:US 192:UK 185:S4 179:AU 111:AU 79:US 1468:: 1233:) 1229:( 1218:e 1211:t 1204:v 1156:. 1095:. 1074:) 1060:. 1027:. 1000:. 887:) 881:( 876:) 872:( 868:. 854:. 621:) 598:2 595:P 592:7 589:O 586:N 580:H 577:7 574:C 520:) 516:( 504:) 207:: 194:: 181:: 113:: 54:/

Index


Trade names
AHFS
Drugs.com
Monograph
License data
DailyMed
Risedronic
Pregnancy
category

Routes of
administration

By mouth
ATC code
M05BA07
WHO
Legal status
S4
POM
โ„ž-only
Pharmacokinetic
Bioavailability
Protein binding
Metabolism
Elimination half-life
Excretion
Kidney
IUPAC name
CAS Number
105462-24-6
PubChem
5245

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