Knowledge (XXG)

Risedronic acid

Source ๐Ÿ“

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rejected P&G's attempted injunction. P&G was criticized for attempting to "preserve its market share by denigrating Boniva". Judge Crotty wrote that "Roche was clearly entitled to respond with its own data, provided that the data was truthfully and accurately presented".
951:. The manufacturers of Boniva, a rival bisphosphonate, were accused in the suit of causing a "serious public health risk" through misrepresentation of scientific findings. In a ruling on September 7, 2006, U.S. District Judge 1227: 195: 1536: 150: 697: 1511: 1220: 1082: 1213: 919:
under the trade names Actonel, Atelvia, and Benet. It is also available in a preparation that includes a calcium carbonate supplement, as Actonel with Calcium.
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In 2006, P&G faced controversy over its handling of clinical research involving risedronate (News Reports and discussion).
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InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
368: 484: 272: 1194: 928: 734: 539: 323: 143: 1381: 1182: 1076: 110: 505: 1436: 1064: 1054: 1029: 1023: 940: 495: 221: 208: 52: 1205: 579: 332: 234: 437: 1531: 1490: 1343: 1318: 1298: 1288: 1283: 1278: 1273: 1268: 1263: 948: 944: 908: 820: 802: 792: 782: 772: 417: 262: 242: 72: 566: 543: 1313: 1308: 1250: 963: 952: 932: 912: 762: 722: 1500: 1441: 555: 1446: 1241: 1237: 726: 163: 158: 1157: 357: 1419: 1411: 1364: 846: 31: 725:. It slows down the cells which break down bone. It's used to treat or prevent 1453: 1426: 1404: 936: 615: 408: 1068: 1463: 1396: 285: 66: 1258: 388: 94: 397: 39: 1458: 343: 17: 966:
drugs, risedronate appears to be associated with the rare side effect
475: 290: 970:, often preceded by dental procedures inducing trauma to the bone. 464: 457: 1389: 638: 629: 511: 448: 202: 1209: 215: 89: 840: 740:
It was patented in 1984 and approved for medical use in 1998.
528: 314:(1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonic acid 189: 121: 704: 1474: 1352: 1329: 1249: 1118:"Boniva advertising 'not misleading' says US judge" 991: 989: 987: 985: 983: 627: 614: 578: 573: 554: 522: 494: 474: 447: 427: 407: 387: 376: 367: 342: 322: 297: 284: 271: 261: 251: 241: 233: 179: 174: 149: 135: 109: 79: 61: 51: 46: 997:"Actonel- risedronate sodium tablet, film coated" 1537:Drugs developed by Takeda Pharmaceutical Company 356: 331: 939:false claims lawsuit against rival drugmakers 1221: 8: 98: 30: 875:. Unsourced material may be challenged and 226:In general: โ„ž (Prescription only) 1512:Farnesyl pyrophosphate synthase inhibitors 1228: 1214: 1206: 1081:: CS1 maint: location missing publisher ( 565: 542: 416: 895:Learn how and when to remove this message 436: 747: 1481: 979: 678: 658: 538: 396: 311: 1074: 1028:. John Wiley & Sons. p. 523. 556: 29: 504: 483: 71: 7: 1201:. U.S. National Library of Medicine. 1189:. U.S. National Library of Medicine. 1160:. Scientific-misconduct.blogspot.com 873:adding citations to reliable sources 510: 162: 1434:Parathyroid hormone-related protein 463: 456: 347: 1051:Essentials of medical pharmacology 605: 25: 1049:Tripathi KD (30 September 2013). 947:claiming false advertising about 661:OC(Cc1cccnc1)(P(=O)(O)O)P(=O)(O)O 1484: 845: 717:, often used as its sodium salt 596: 590: 38: 1053:(Seventh ed.). New Delhi. 1022:Fischer J, Ganellin CR (2006). 907:It is produced and marketed by 686:Key:IIDJRNMFWXDHID-UHFFFAOYSA-N 57:Actonel, Atelvia, Benet, others 599: 584: 1: 1025:Analogue-based Drug Discovery 1158:"Scientific Misconduct Blog" 1136:"Actonel Case Media Reports" 1331:Bone morphogenetic proteins 1553: 1140:Scientific Misconduct Wiki 931:and its marketing partner 574:Chemical and physical data 1527:Drugs developed by AbbVie 1097:"P&G Press statement" 694: 669: 649: 302: 37: 968:osteonecrosis of the jaw 1372:Aluminium chlorohydrate 1236:Drugs for treatment of 1199:Drug Information Portal 1187:Drug Information Portal 731:Paget's disease of bone 1377:Dual action bone agent 962:In common with other 1517:Procter & Gamble 1360:Resorption inhibitor 1195:"Risedronate sodium" 869:improve this section 1522:3-Pyridyl compounds 1146:on 2 February 2009. 1124:. 8 September 2006. 832:Society and culture 750: 211:(Prescription only) 198:(Prescription only) 34: 1382:Strontium ranelate 915:, and in Japan by 748: 719:risedronate sodium 1472: 1471: 1183:"Risedronic acid" 1003:. 1 November 2019 905: 904: 897: 829: 828: 757:Relative potency 749:Relative potency 712: 711: 640:Interactive image 524:CompTox Dashboard 219: 206: 193: 125: 92: 27:Chemical compound 16:(Redirected from 1544: 1489: 1488: 1487: 1480: 1305:Non-nitrogenous 1230: 1223: 1216: 1207: 1202: 1190: 1169: 1168: 1166: 1165: 1154: 1148: 1147: 1142:. Archived from 1132: 1126: 1125: 1114: 1108: 1107: 1105: 1104: 1093: 1087: 1086: 1080: 1072: 1046: 1040: 1039: 1019: 1013: 1012: 1010: 1008: 993: 927:In January 2006 900: 893: 889: 886: 880: 849: 841: 751: 708: 707: 700: 642: 622: 607: 601: 598: 592: 586: 569: 558: 547: 546: 532: 530: 514: 508: 487: 467: 460: 440: 420: 400: 380: 360: 350: 349: 335: 276: 217: 214: 204: 201: 191: 188: 166: 123: 120: 102: 91: 88: 75: 42: 35: 33: 21: 1552: 1551: 1547: 1546: 1545: 1543: 1542: 1541: 1507:Bisphosphonates 1497: 1496: 1495: 1485: 1483: 1475: 1473: 1468: 1348: 1344:Eptotermin alfa 1339:Dibotermin alfa 1325: 1319:Tiludronic acid 1299:Zoledronic acid 1294:Risedronic acid 1289:Pamidronic acid 1284:Neridronic acid 1279:Minodronic acid 1274:Incadronic acid 1269:Ibandronic acid 1264:Alendronic acid 1251:Bisphosphonates 1245: 1234: 1193: 1181: 1178: 1173: 1172: 1163: 1161: 1156: 1155: 1151: 1134: 1133: 1129: 1116: 1115: 1111: 1102: 1100: 1095: 1094: 1090: 1073: 1061: 1048: 1047: 1043: 1036: 1021: 1020: 1016: 1006: 1004: 995: 994: 981: 976: 945:GlaxoSmithKline 925: 909:Warner Chilcott 901: 890: 884: 881: 866: 850: 839: 834: 754:Bisphosphonate 746: 715:Risedronic acid 703: 701: 698:(what is this?) 695: 690: 687: 682: 677: 676: 665: 662: 657: 656: 645: 620: 610: 604: 595: 589: 550: 526: 518: 490: 470: 443: 423: 403: 383: 363: 346: 338: 318: 315: 310: 309: 274: 253:Protein binding 243:Bioavailability 235:Pharmacokinetic 229: 170: 138: 131: 112: 105: 32:Risedronic acid 28: 23: 22: 15: 12: 11: 5: 1550: 1548: 1540: 1539: 1534: 1529: 1524: 1519: 1514: 1509: 1499: 1498: 1494: 1493: 1470: 1469: 1467: 1466: 1461: 1456: 1451: 1450: 1449: 1444: 1431: 1430: 1429: 1416: 1415: 1414: 1401: 1400: 1399: 1386: 1385: 1384: 1374: 1369: 1368: 1367: 1356: 1354: 1350: 1349: 1347: 1346: 1341: 1335: 1333: 1327: 1326: 1324: 1323: 1322: 1321: 1316: 1314:Clodronic acid 1311: 1309:Etidronic acid 1303: 1302: 1301: 1296: 1291: 1286: 1281: 1276: 1271: 1266: 1255: 1253: 1247: 1246: 1235: 1233: 1232: 1225: 1218: 1210: 1204: 1203: 1191: 1177: 1176:External links 1174: 1171: 1170: 1149: 1127: 1109: 1088: 1059: 1041: 1034: 1014: 978: 977: 975: 972: 964:bisphosphonate 953:Paul A. Crotty 933:Sanofi-Aventis 924: 921: 913:Sanofi-Aventis 903: 902: 885:September 2023 853: 851: 844: 838: 835: 833: 830: 827: 826: 823: 817: 816: 813: 809: 808: 805: 799: 798: 795: 789: 788: 785: 779: 778: 775: 769: 768: 765: 759: 758: 755: 745: 742: 733:. It is taken 723:bisphosphonate 710: 709: 692: 691: 689: 688: 685: 683: 680: 672: 671: 670: 667: 666: 664: 663: 660: 652: 651: 650: 647: 646: 644: 643: 635: 633: 625: 624: 618: 612: 611: 608: 602: 593: 587: 582: 576: 575: 571: 570: 560: 552: 551: 549: 548: 535: 533: 520: 519: 517: 516: 500: 498: 492: 491: 489: 488: 480: 478: 472: 471: 469: 468: 461: 453: 451: 445: 444: 442: 441: 433: 431: 425: 424: 422: 421: 413: 411: 405: 404: 402: 401: 393: 391: 385: 384: 382: 381: 373: 371: 365: 364: 362: 361: 353: 351: 340: 339: 337: 336: 328: 326: 320: 319: 317: 316: 313: 305: 304: 303: 300: 299: 295: 294: 288: 282: 281: 278: 269: 268: 265: 259: 258: 255: 249: 248: 245: 239: 238: 231: 230: 228: 227: 224: 212: 199: 185: 183: 177: 176: 172: 171: 169: 168: 155: 153: 147: 146: 141: 139:administration 133: 132: 130: 129: 127: 117: 115: 107: 106: 104: 103: 85: 83: 77: 76: 69: 59: 58: 55: 49: 48: 44: 43: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 1549: 1538: 1535: 1533: 1530: 1528: 1525: 1523: 1520: 1518: 1515: 1513: 1510: 1508: 1505: 1504: 1502: 1492: 1482: 1478: 1465: 1462: 1460: 1457: 1455: 1452: 1448: 1445: 1443: 1442:Abaloparatide 1440: 1439: 1438: 1435: 1432: 1428: 1425: 1424: 1423: 1421: 1417: 1413: 1410: 1409: 1408: 1406: 1402: 1398: 1395: 1394: 1393: 1391: 1387: 1383: 1380: 1379: 1378: 1375: 1373: 1370: 1366: 1363: 1362: 1361: 1358: 1357: 1355: 1351: 1345: 1342: 1340: 1337: 1336: 1334: 1332: 1328: 1320: 1317: 1315: 1312: 1310: 1307: 1306: 1304: 1300: 1297: 1295: 1292: 1290: 1287: 1285: 1282: 1280: 1277: 1275: 1272: 1270: 1267: 1265: 1262: 1261: 1260: 1257: 1256: 1254: 1252: 1248: 1243: 1239: 1238:bone diseases 1231: 1226: 1224: 1219: 1217: 1212: 1211: 1208: 1200: 1196: 1192: 1188: 1184: 1180: 1179: 1175: 1159: 1153: 1150: 1145: 1141: 1137: 1131: 1128: 1123: 1119: 1113: 1110: 1098: 1092: 1089: 1084: 1078: 1070: 1066: 1062: 1060:9789350259375 1056: 1052: 1045: 1042: 1037: 1035:9783527607495 1031: 1027: 1026: 1018: 1015: 1002: 998: 992: 990: 988: 986: 984: 980: 973: 971: 969: 965: 960: 957: 954: 950: 946: 942: 938: 934: 930: 923:Controversies 922: 920: 918: 914: 910: 899: 896: 888: 878: 874: 870: 864: 863: 859: 854:This section 852: 848: 843: 842: 836: 831: 824: 822: 819: 818: 814: 811: 810: 806: 804: 801: 800: 796: 794: 791: 790: 786: 784: 781: 780: 776: 774: 771: 770: 766: 764: 761: 760: 756: 753: 752: 743: 741: 738: 736: 732: 728: 724: 720: 716: 706: 699: 693: 684: 679: 675: 668: 659: 655: 648: 641: 637: 636: 634: 631: 626: 619: 617: 613: 583: 581: 577: 572: 568: 564: 561: 559: 557:ECHA InfoCard 553: 545: 541: 540:DTXSID2023563 537: 536: 534: 525: 521: 513: 512:RCSB PDB 507: 502: 501: 499: 497: 493: 486: 482: 481: 479: 477: 473: 466: 462: 459: 455: 454: 452: 450: 446: 439: 435: 434: 432: 430: 426: 419: 415: 414: 412: 410: 406: 399: 395: 394: 392: 390: 386: 379: 375: 374: 372: 370: 366: 359: 355: 354: 352: 345: 341: 334: 330: 329: 327: 325: 321: 312: 308: 301: 296: 292: 289: 287: 283: 279: 277: 270: 266: 264: 260: 256: 254: 250: 246: 244: 240: 236: 232: 225: 223: 213: 210: 200: 197: 187: 186: 184: 182: 178: 173: 165: 160: 157: 156: 154: 152: 148: 145: 142: 140: 134: 128: 119: 118: 116: 114: 108: 101: 96: 87: 86: 84: 82: 78: 74: 70: 68: 64: 60: 56: 54: 50: 47:Clinical data 45: 41: 36: 19: 1447:Teriparatide 1418: 1403: 1388: 1376: 1359: 1293: 1198: 1186: 1162:. Retrieved 1152: 1144:the original 1139: 1130: 1122:Pharma Times 1121: 1112: 1101:. Retrieved 1091: 1050: 1044: 1024: 1017: 1005:. Retrieved 1000: 961: 958: 926: 906: 891: 882: 867:Please help 855: 812:Risedronate 744:Pharmacology 739: 729:, and treat 727:osteoporosis 718: 714: 713: 702:   696:   273:Elimination 181:Legal status 175:Legal status 81:License data 1420:Cathepsin K 1412:Romosozumab 1365:Ipriflavone 1259:Nitrogenous 1099:. Uk.pg.com 837:Brand names 821:Zoledronate 803:Ibandronate 793:Alendronate 783:Pamidronate 773:Tiludronate 623: gยทmol 563:100.116.436 333:105462-24-6 298:Identifiers 53:Trade names 1501:Categories 1454:Calcitonin 1427:Odanacatib 1405:Sclerostin 1164:2013-03-01 1103:2013-03-01 974:References 937:Lanham Act 763:Etidronate 628:3D model ( 616:Molar mass 496:PDB ligand 438:KM2Z91756Z 409:ChemSpider 369:IUPHAR/BPS 324:CAS Number 307:IUPAC name 263:Metabolism 100:Risedronic 1464:Vitamin D 1437:analogues 1422:inhibitor 1407:inhibitor 1397:Denosumab 1392:inhibitor 1077:cite book 1069:868299888 856:does not 807:500-1000 485:ChEMBL923 293:and fecal 286:Excretion 275:half-life 137:Routes of 111:Pregnancy 73:Monograph 67:Drugs.com 1491:Medicine 1001:DailyMed 935:filed a 797:100-500 735:by mouth 705:(verify) 389:DrugBank 151:ATC code 144:By mouth 126: B3 113:category 95:DailyMed 1459:Calcium 1007:28 June 929:P&G 877:removed 862:sources 721:, is a 621:283.113 580:Formula 398:DB00884 344:PubChem 167:) 161: ( 159:M05BA07 97::  18:Actonel 1532:Sanofi 1477:Portal 1067:  1057:  1032:  949:Boniva 917:Takeda 654:SMILES 476:ChEMBL 465:D03234 458:D00942 291:Kidney 222:โ„ž-only 220: 207: 194: 93:  1390:RANKL 1353:Other 941:Roche 825:5000 815:1000 674:InChI 630:JSmol 503:RIS ( 280:1.5 h 247:0.63% 1083:link 1065:OCLC 1055:ISBN 1030:ISBN 1009:2022 943:and 860:any 858:cite 787:100 506:PDBe 449:KEGG 429:UNII 418:5055 378:3176 358:5245 267:None 257:~24% 237:data 63:AHFS 1242:M05 871:by 777:10 529:EPA 348:CID 209:POM 164:WHO 1503:: 1197:. 1185:. 1138:. 1120:. 1079:}} 1075:{{ 1063:. 999:. 982:^ 911:, 767:1 737:. 594:11 509:, 216:US 203:UK 196:S4 190:AU 122:AU 90:US 1479:: 1244:) 1240:( 1229:e 1222:t 1215:v 1167:. 1106:. 1085:) 1071:. 1038:. 1011:. 898:) 892:( 887:) 883:( 879:. 865:. 632:) 609:2 606:P 603:7 600:O 597:N 591:H 588:7 585:C 531:) 527:( 515:) 218:: 205:: 192:: 124:: 65:/ 20:)

Index

Actonel

Trade names
AHFS
Drugs.com
Monograph
License data
DailyMed
Risedronic
Pregnancy
category

Routes of
administration

By mouth
ATC code
M05BA07
WHO
Legal status
S4
POM
โ„ž-only
Pharmacokinetic
Bioavailability
Protein binding
Metabolism
Elimination half-life
Excretion
Kidney
IUPAC name
CAS Number
105462-24-6
PubChem

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