693:
29:
3852:
625:, though, on the other features. For instance, their expression pattern is cell-specific, i.e. they are expressed in particular cell types. Their expression depends on environmental factors. In contrast, calmodulin is a ubiquitous and universal intracellular Ca receptor widely expressed in many cells.
683:
S100 proteins have been implicated in a variety of intracellular and extracellular functions, such as regulation of protein phosphorylation, transcription factors, Ca homeostasis, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory
945:
2101:
1518:"Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15"
1209:"Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15"
1123:
Shinzato M, Shamoto M, Hosokawa S, Kaneko C, Osada A, Shimizu M, Yoshida A (1995). "Differentiation of
Langerhans cells from interdigitating cells using CD1a and S-100 protein antibodies".
1483:"The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation"
731:. Further, S100 proteins are markers for inflammatory diseases and can mediate inflammation and act as antimicrobials. S100 proteins have been used in the lab as cell markers for
1088:
Coppola D, Fu L, Nicosia SV, Kounelis S, Jones M (1998). "Prognostic significance of p53, bcl-2, vimentin, and S100 protein-positive
Langerhans cells in endometrial carcinoma".
1256:
Nonaka D, Chiriboga L, Rubin BP (2008). "Differential expression of S100 protein subtypes in malignant melanoma, and benign and malignant peripheral nerve sheath tumors".
140:
2803:
2086:
969:
Marenholz I, Heizmann CW, Fritz G (2004). "S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)".
684:
response. S100A7 (psoriasin) and S100A15 have been found to act as cytokines in inflammation, particularly in autoimmune skin conditions such as psoriasis.
1683:
617:
Most S100 proteins consist of two identical polypeptides (homodimeric), which are held together by noncovalent bonds. They are structurally similar to
1516:
Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH (2008).
1207:
Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH (2008).
1006:"Engagement of the Aryl Hydrocarbon Receptor in Mycobacterium tuberculosis-Infected Macrophages Has Pleiotropic Effects on Innate Immune Signaling"
3017:
720:
2181:
1602:
Wolf R, Mascia F, Dharamsi A, Howard OM, Cataisson C, Bliskovski V, Winston J, Feigenbaum L, Lichti U, Ruzicka T, Chavakis T, Yuspa SH (2010).
1045:
Wilson, AJ; Maddox, PH; Jenkins, D (January 1991). "CD1a and S100 antigen expression in skin
Langerhans cells in patients with breast cancer".
88:
1901:
711:
Several members of the S100 protein family are useful as markers for certain tumors and epidermal differentiation. They can be found in
3209:
2796:
1415:
Penumutchu, Srinivasa R.; Chou, Ruey-Hwang; Yu, Chin (2014-10-17). "Interaction between S100P and the anti-allergy drug cromolyn".
3456:
3395:
933:
3635:
3227:
2119:
2109:
1676:
3531:
160:
3877:
3625:
3295:
2789:
1869:
1840:
1559:
Wolf R, Voscopoulos C, Winston J, Dharamsi A, Goldsmith P, Gunsior M, Vonderhaar BK, Olson M, Watson PH, Yuspa SH (2009).
3842:
3578:
3509:
3481:
3254:
3010:
2451:
2260:
1301:"Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function"
1561:"Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer"
3620:
2697:
1669:
3882:
3615:
2905:
606:
1481:
Wolf R, Voscopoulos CJ, FitzGerald PC, Goldsmith P, Cataisson C, Gunsior M, Walz M, Ruzicka T, Yuspa SH (2006).
3410:
3385:
3357:
3285:
3115:
3106:
2935:
2159:
1966:
1936:
1830:
1655:
148:
2925:
2245:
1661:
3872:
3678:
3489:
3003:
1894:
1889:
1884:
1879:
1874:
692:
3523:
3390:
2081:
144:
3149:
2816:
2626:
1361:
579:-type") conformation. At least 21 different S100 proteins are known. They are encoded by a family of
101:
3470:
2910:
2592:
2409:
2064:
2672:
2114:
2044:
2034:
1906:
1862:
1717:
1700:
1281:
1189:
1070:
732:
728:
701:
654:
2019:
3583:
3570:
3495:
3418:
3372:
3344:
3180:
2687:
2091:
2073:
1696:
1633:
1590:
1547:
1504:
1440:
1432:
1397:
1379:
1330:
1273:
1238:
1181:
1140:
1105:
1062:
1027:
986:
929:
866:
167:
135:
3817:
3126:
3067:
2682:
2500:
1850:
1623:
1615:
1580:
1572:
1537:
1529:
1494:
1424:
1387:
1369:
1320:
1312:
1265:
1228:
1220:
1171:
1132:
1097:
1054:
1017:
978:
921:
572:
2554:
1795:
908:
860:
127:
3670:
3607:
3545:
3503:
3310:
3134:
2842:
2832:
2765:
1928:
1822:
1760:
920:
The "S100" symbol prefix denotes that these proteins are soluble in 100%, i.e. saturated,
890:
874:
666:
662:
1651:
1365:
3856:
3688:
3447:
3162:
3093:
2890:
2873:
2837:
2737:
1835:
1692:
1628:
1603:
1585:
1560:
1542:
1517:
1392:
1349:
1325:
1300:
1233:
1208:
28:
1101:
3866:
3711:
3172:
3157:
3101:
3059:
2974:
2878:
2755:
2314:
2304:
2230:
1855:
1845:
1708:
1269:
705:
93:
1285:
1193:
1074:
57:
3537:
3517:
3237:
3026:
2930:
2667:
2417:
2309:
1350:"Structural Insights into Calcium-Bound S100P and the V Domain of the RAGE Complex"
1004:
Memari B, Bouttier M, Dimitrov V, Ouellette M, Behr MA, Fritz JH, White JH (2015).
950:
724:
670:
638:
634:
123:
1619:
1576:
1374:
69:
3796:
3734:
3323:
3314:
3277:
3219:
3201:
2945:
2920:
2781:
2722:
2702:
2677:
2299:
2282:
2277:
2049:
2039:
1740:
1730:
1533:
1224:
716:
697:
646:
3851:
1428:
982:
3787:
3110:
3049:
2962:
2957:
2770:
2587:
2386:
2250:
2235:
2198:
2029:
2014:
2009:
2004:
1999:
1994:
1989:
1984:
1316:
1136:
677:
658:
642:
622:
618:
564:
1604:"Gene from a psoriasis susceptibility locus primes the skin for inflammation"
1436:
1383:
1022:
1005:
3783:
3290:
3139:
2824:
2745:
2617:
2602:
2597:
2287:
2255:
2193:
1058:
880:
650:
1637:
1594:
1551:
1508:
1499:
1482:
1444:
1401:
1334:
1277:
1242:
1185:
1031:
990:
1144:
1109:
1066:
97:
3773:
3739:
3724:
3241:
3041:
2952:
2863:
2750:
2511:
2422:
2240:
2185:
1725:
1458:
712:
64:
16:
Family of vertebrate proteins involved in cell division and inflammation
3765:
3719:
3655:
3551:
2979:
2812:
2760:
2714:
2635:
2519:
2432:
2169:
2024:
1976:
1176:
1159:
946:
List of histologic stains that aid in diagnosis of cutaneous conditions
835:
829:
823:
817:
811:
805:
787:
576:
568:
560:
81:
76:
3825:
3640:
3587:
3462:
3422:
3380:
3352:
2900:
2868:
2569:
2539:
2481:
2476:
2471:
2466:
2461:
2443:
2270:
2265:
2223:
2218:
2164:
2152:
2147:
2142:
1946:
1941:
799:
793:
781:
775:
769:
763:
757:
751:
745:
674:
155:
33:
Structure of the S100B protein. Based on PyMOL rendering of PDB 1b4c.
541:
535:
528:
522:
516:
510:
504:
498:
492:
486:
480:
474:
468:
462:
456:
450:
444:
438:
432:
426:
420:
414:
408:
402:
396:
390:
384:
378:
372:
366:
360:
354:
348:
342:
336:
330:
324:
318:
312:
306:
300:
294:
288:
282:
276:
270:
264:
258:
252:
246:
240:
234:
228:
222:
216:
210:
204:
198:
192:
185:
179:
173:
1348:
Penumutchu, Srinivasa R.; Chou, Ruey-Hwang; Yu, Chin (2014-08-01).
3744:
3729:
3701:
3696:
3660:
3645:
3630:
3597:
3559:
3400:
3362:
3300:
3072:
2984:
2895:
2858:
2660:
2655:
2650:
2645:
2640:
2564:
2559:
2549:
2544:
2534:
2529:
2524:
2493:
2488:
2456:
2427:
2396:
2391:
2381:
2369:
2364:
2359:
2292:
2213:
2208:
2203:
2137:
1810:
1805:
1800:
1790:
1785:
1780:
1775:
854:
848:
842:
691:
602:
3650:
3592:
3476:
2995:
2967:
2915:
2885:
2692:
2354:
2349:
2344:
2339:
2334:
2329:
2324:
2319:
1958:
1916:
1911:
1770:
1765:
1755:
1750:
1745:
1735:
902:
896:
580:
117:
52:
2999:
2785:
1665:
609:
downregulates the expression of S100 proteins in THP-1 cells.
633:
S100 proteins are normally present in cells derived from the
925:
719:, 100% of neurofibromas (weaker than schwannomas), 50% of
723:(may be weak and/or focal), paraganglioma stromal cells,
1160:"Intracellular and extracellular roles of S100 proteins"
1462:
3840:
928:. The symbol has often been hyphenated, but current
3816:
3809:
3782:
3764:
3757:
3710:
3687:
3669:
3606:
3569:
3446:
3435:
3409:
3371:
3343:
3336:
3309:
3276:
3267:
3236:
3218:
3200:
3193:
3171:
3148:
3125:
3092:
3085:
3058:
3040:
3033:
2851:
2823:
2735:
2713:
2625:
2615:
2580:
2509:
2441:
2407:
2180:
2130:
2100:
2072:
2062:
1975:
1957:
1927:
1821:
1716:
1707:
1417:
971:
166:
154:
134:
116:
111:
87:
75:
63:
51:
43:
38:
21:
936:nomenclature, does not use hyphens in symbols.
3011:
2797:
1677:
603:damage-associated molecular pattern molecules
8:
3813:
3761:
3443:
3340:
3273:
3197:
3089:
3037:
3018:
3004:
2996:
2804:
2790:
2782:
2622:
2069:
1713:
1684:
1670:
1662:
108:
27:
1654:at the U.S. National Library of Medicine
1627:
1584:
1541:
1498:
1391:
1373:
1324:
1299:Wolf R, Ruzicka T, Yuspa SH (July 2010).
1232:
1175:
1021:
1487:The Journal of Investigative Dermatology
1464:Dorland's Illustrated Medical Dictionary
721:malignant peripheral nerve sheath tumors
3847:
961:
22:S100/ICaBP type calcium binding domain
18:
559:are a family of low molecular-weight
7:
14:
1164:Microscopy Research and Technique
3850:
3457:Surface epithelial-stromal tumor
3396:Tumor-associated glycoprotein 72
1270:10.1111/j.1600-0560.2007.00953.x
934:HUGO Gene Nomenclature Committee
588:
3636:Early prostate cancer antigen-2
3228:Glial fibrillary acidic protein
2120:Calcium-induced calcium release
1125:Biotechnic & Histochemistry
673:. They may be present in some
1841:Ionotropic glutamate receptors
1608:Science Translational Medicine
1258:Journal of Cutaneous Pathology
601:. They are also considered as
1:
3626:Glutamate carboxypeptidase II
1102:10.1016/s0046-8177(98)90060-0
930:gene and protein nomenclature
112:Available protein structures:
3255:Melanoma inhibitory activity
2693:Dentin matrix phosphoprotein
1620:10.1126/scitranslmed.3001108
1577:10.1016/j.canlet.2008.11.032
1375:10.1371/journal.pone.0103947
1534:10.4049/jimmunol.181.2.1499
1225:10.4049/jimmunol.181.2.1499
3899:
3621:Prostatic acid phosphatase
3532:Sertoli–Leydig cell tumour
2698:Dentin sialophosphoprotein
1429:10.1016/j.bbrc.2014.10.048
983:10.1016/j.bbrc.2004.07.096
605:(DAMPs), and knockdown of
3616:Prostate-specific antigen
3296:Autocrine motility factor
2906:Brain natriuretic peptide
2160:Sodium-calcium exchangers
1937:Sodium-calcium exchangers
1317:10.1007/s00726-010-0666-4
1137:10.3109/10520299509108327
607:aryl hydrocarbon receptor
571:-binding sites that have
107:
26:
3411:Hepatocellular carcinoma
3386:Carcinoembryonic antigen
3358:Carcinoembryonic antigen
3286:Carcinoembryonic antigen
3116:Carcinoembryonic antigen
3107:Medullary thyroid cancer
2936:Olfactory marker protein
2246:Neuronal calcium sensors
1967:Calcium-sensing receptor
1656:Medical Subject Headings
1047:The Journal of Pathology
1023:10.4049/jimmunol.1501141
2926:Neuronal calcium sensor
1059:10.1002/path.1711630106
2102:Intracellular channels
1500:10.1038/sj.jid.5700210
708:
583:whose symbols use the
3150:Neuroendocrine tumors
1522:Journal of Immunology
1213:Journal of Immunology
1010:Journal of Immunology
695:
587:prefix, for example,
567:characterized by two
3878:Diagnostic neurology
2817:nerve tissue protein
2627:Extracellular matrix
2911:Nerve growth factor
2593:Parathyroid hormone
2581:Indirect regulators
2131:Intracellular pumps
1366:2014PLoSO...9j3947P
729:clear-cell sarcomas
702:sustentacular cells
655:myoepithelial cells
621:. They differ from
2673:Matrix gla protein
2510:Calcium-dependent
2442:Calcium-dependent
2408:Calcium-dependent
2115:Ryanodine receptor
1718:Adhesion molecules
1701:calcium metabolism
1177:10.1002/jemt.10296
733:anatomic pathology
709:
3838:
3837:
3834:
3833:
3805:
3804:
3758:General histology
3753:
3752:
3584:Alpha-fetoprotein
3571:Testicular cancer
3496:Alpha-fetoprotein
3431:
3430:
3419:Alpha-fetoprotein
3373:Pancreatic cancer
3345:Colorectal cancer
3332:
3331:
3263:
3262:
3189:
3188:
3181:Homovanillic acid
3081:
3080:
2993:
2992:
2779:
2778:
2731:
2730:
2715:Secreted hormones
2688:Bone sialoprotein
2611:
2610:
2074:Second messengers
2058:
2057:
1851:Kainate receptors
1697:calcium signaling
1158:Donato R (2003).
821:(calgranulin C),
803:(calgranulin B),
797:(calgranulin A),
553:
552:
549:
548:
161:structure summary
3890:
3883:Protein families
3855:
3854:
3846:
3818:Rhabdomyosarcoma
3814:
3762:
3444:
3341:
3274:
3198:
3127:Pheochromocytoma
3090:
3038:
3020:
3013:
3006:
2997:
2806:
2799:
2792:
2783:
2736:Calcium-binding
2623:
2501:Protein kinase C
2070:
1823:Calcium channels
1714:
1686:
1679:
1672:
1663:
1641:
1631:
1598:
1588:
1555:
1545:
1512:
1502:
1469:
1468:
1455:
1449:
1448:
1412:
1406:
1405:
1395:
1377:
1345:
1339:
1338:
1328:
1296:
1290:
1289:
1253:
1247:
1246:
1236:
1204:
1198:
1197:
1179:
1155:
1149:
1148:
1120:
1114:
1113:
1085:
1079:
1078:
1042:
1036:
1035:
1025:
1001:
995:
994:
966:
922:ammonium sulfate
678:epithelial cells
663:Langerhans cells
573:helix-loop-helix
544:
538:
531:
525:
519:
513:
507:
501:
495:
489:
483:
477:
471:
465:
459:
453:
447:
441:
435:
429:
423:
417:
411:
405:
399:
393:
387:
381:
375:
369:
363:
357:
351:
345:
339:
333:
327:
321:
315:
309:
303:
297:
291:
285:
279:
273:
267:
261:
255:
249:
243:
237:
231:
225:
219:
213:
207:
201:
195:
188:
182:
176:
109:
31:
19:
3898:
3897:
3893:
3892:
3891:
3889:
3888:
3887:
3863:
3862:
3861:
3849:
3841:
3839:
3830:
3810:Musculoskeletal
3801:
3778:
3749:
3730:erbB-3 receptor
3725:erbB-2 receptor
3706:
3697:erbB-3 receptor
3683:
3671:Germ cell tumor
3665:
3631:erbB-3 receptor
3608:Prostate cancer
3602:
3565:
3504:Choriocarcinoma
3439:
3437:
3427:
3405:
3367:
3328:
3311:Hemangiosarcoma
3305:
3269:
3268:Cardiovascular/
3259:
3232:
3214:
3185:
3167:
3144:
3135:Normetanephrine
3121:
3077:
3054:
3029:
3024:
2994:
2989:
2847:
2843:Gamma-synuclein
2833:Alpha-synuclein
2819:
2810:
2780:
2775:
2766:EGF-like domain
2727:
2709:
2607:
2576:
2505:
2437:
2403:
2176:
2126:
2096:
2054:
1971:
1953:
1923:
1817:
1703:
1690:
1648:
1601:
1558:
1528:(2): 1499–506.
1515:
1480:
1477:
1475:Further reading
1472:
1457:
1456:
1452:
1414:
1413:
1409:
1347:
1346:
1342:
1298:
1297:
1293:
1255:
1254:
1250:
1219:(2): 1499–506.
1206:
1205:
1201:
1157:
1156:
1152:
1122:
1121:
1117:
1090:Human Pathology
1087:
1086:
1082:
1044:
1043:
1039:
1003:
1002:
998:
968:
967:
963:
959:
942:
918:
791:(koebnerisin),
741:
690:
667:dendritic cells
631:
629:Normal function
615:
540:
534:
527:
521:
515:
509:
503:
497:
491:
485:
479:
473:
467:
461:
455:
449:
443:
437:
431:
425:
419:
413:
407:
401:
395:
389:
383:
377:
371:
365:
359:
353:
347:
341:
335:
329:
323:
317:
311:
305:
299:
293:
287:
281:
275:
269:
263:
257:
251:
245:
239:
233:
227:
221:
215:
209:
203:
197:
191:
184:
178:
172:
34:
17:
12:
11:
5:
3896:
3894:
3886:
3885:
3880:
3875:
3865:
3864:
3860:
3859:
3836:
3835:
3832:
3831:
3829:
3828:
3822:
3820:
3811:
3807:
3806:
3803:
3802:
3800:
3799:
3793:
3791:
3780:
3779:
3777:
3776:
3770:
3768:
3759:
3755:
3754:
3751:
3750:
3748:
3747:
3742:
3737:
3732:
3727:
3722:
3716:
3714:
3708:
3707:
3705:
3704:
3699:
3693:
3691:
3689:Bladder cancer
3685:
3684:
3682:
3681:
3675:
3673:
3667:
3666:
3664:
3663:
3658:
3653:
3648:
3643:
3638:
3633:
3628:
3623:
3618:
3612:
3610:
3604:
3603:
3601:
3600:
3595:
3590:
3581:
3575:
3573:
3567:
3566:
3564:
3563:
3556:
3555:
3554:
3542:
3541:
3540:
3528:
3527:
3526:
3514:
3513:
3512:
3500:
3499:
3498:
3486:
3485:
3484:
3479:
3467:
3466:
3465:
3452:
3450:
3441:
3433:
3432:
3429:
3428:
3426:
3425:
3415:
3413:
3407:
3406:
3404:
3403:
3398:
3393:
3388:
3383:
3377:
3375:
3369:
3368:
3366:
3365:
3360:
3355:
3349:
3347:
3338:
3334:
3333:
3330:
3329:
3327:
3326:
3320:
3318:
3307:
3306:
3304:
3303:
3298:
3293:
3288:
3282:
3280:
3271:
3265:
3264:
3261:
3260:
3258:
3257:
3252:
3246:
3244:
3234:
3233:
3231:
3230:
3224:
3222:
3216:
3215:
3213:
3212:
3206:
3204:
3195:
3194:Nervous system
3191:
3190:
3187:
3186:
3184:
3183:
3177:
3175:
3169:
3168:
3166:
3165:
3163:Chromogranin A
3160:
3154:
3152:
3146:
3145:
3143:
3142:
3137:
3131:
3129:
3123:
3122:
3120:
3119:
3113:
3104:
3098:
3096:
3094:Thyroid cancer
3087:
3083:
3082:
3079:
3078:
3076:
3075:
3070:
3064:
3062:
3056:
3055:
3053:
3052:
3046:
3044:
3035:
3031:
3030:
3025:
3023:
3022:
3015:
3008:
3000:
2991:
2990:
2988:
2987:
2982:
2977:
2972:
2971:
2970:
2965:
2960:
2950:
2949:
2948:
2938:
2933:
2928:
2923:
2918:
2913:
2908:
2903:
2898:
2893:
2891:Gap-43 protein
2888:
2883:
2882:
2881:
2876:
2874:Chromogranin A
2866:
2861:
2855:
2853:
2849:
2848:
2846:
2845:
2840:
2838:Beta-synuclein
2835:
2829:
2827:
2821:
2820:
2811:
2809:
2808:
2801:
2794:
2786:
2777:
2776:
2774:
2773:
2768:
2763:
2758:
2753:
2748:
2742:
2740:
2733:
2732:
2729:
2728:
2726:
2725:
2719:
2717:
2711:
2710:
2708:
2707:
2706:
2705:
2700:
2695:
2690:
2680:
2675:
2670:
2665:
2664:
2663:
2658:
2653:
2648:
2643:
2632:
2630:
2620:
2616:Extracellular
2613:
2612:
2609:
2608:
2606:
2605:
2600:
2595:
2590:
2584:
2582:
2578:
2577:
2575:
2574:
2573:
2572:
2567:
2562:
2557:
2552:
2547:
2542:
2537:
2532:
2527:
2516:
2514:
2507:
2506:
2504:
2503:
2498:
2497:
2496:
2491:
2486:
2485:
2484:
2479:
2474:
2469:
2459:
2448:
2446:
2439:
2438:
2436:
2435:
2430:
2425:
2420:
2414:
2412:
2405:
2404:
2402:
2401:
2400:
2399:
2394:
2384:
2379:
2374:
2373:
2372:
2367:
2362:
2357:
2352:
2347:
2342:
2337:
2332:
2327:
2322:
2315:Synaptotagmins
2312:
2307:
2302:
2297:
2296:
2295:
2290:
2285:
2280:
2275:
2274:
2273:
2268:
2258:
2253:
2243:
2238:
2233:
2228:
2227:
2226:
2221:
2216:
2211:
2206:
2196:
2190:
2188:
2178:
2177:
2175:
2174:
2173:
2172:
2167:
2157:
2156:
2155:
2150:
2145:
2134:
2132:
2128:
2127:
2125:
2124:
2123:
2122:
2112:
2106:
2104:
2098:
2097:
2095:
2094:
2089:
2084:
2078:
2076:
2067:
2063:Intracellular
2060:
2059:
2056:
2055:
2053:
2052:
2047:
2042:
2037:
2032:
2027:
2022:
2017:
2012:
2007:
2002:
1997:
1992:
1987:
1981:
1979:
1973:
1972:
1970:
1969:
1963:
1961:
1955:
1954:
1952:
1951:
1950:
1949:
1944:
1933:
1931:
1925:
1924:
1922:
1921:
1920:
1919:
1914:
1909:
1899:
1898:
1897:
1892:
1887:
1882:
1877:
1867:
1866:
1865:
1860:
1859:
1858:
1856:NMDA receptors
1853:
1848:
1846:AMPA receptors
1838:
1836:5-HT3 receptor
1827:
1825:
1819:
1818:
1816:
1815:
1814:
1813:
1808:
1803:
1798:
1793:
1788:
1783:
1778:
1773:
1768:
1763:
1758:
1753:
1748:
1743:
1738:
1733:
1722:
1720:
1711:
1705:
1704:
1693:Cell signaling
1691:
1689:
1688:
1681:
1674:
1666:
1660:
1659:
1647:
1646:External links
1644:
1643:
1642:
1614:(61): 61ra90.
1599:
1565:Cancer Letters
1556:
1513:
1476:
1473:
1471:
1470:
1450:
1423:(3): 404–409.
1407:
1360:(8): e103947.
1340:
1291:
1264:(11): 1014–9.
1248:
1199:
1150:
1115:
1080:
1037:
1016:(9): 4479–91.
996:
977:(4): 1111–22.
960:
958:
955:
954:
953:
948:
941:
938:
917:
914:
913:
912:
871:
839:
740:
737:
689:
686:
630:
627:
614:
611:
551:
550:
547:
546:
170:
164:
163:
158:
152:
151:
138:
132:
131:
121:
114:
113:
105:
104:
91:
85:
84:
79:
73:
72:
67:
61:
60:
55:
49:
48:
45:
41:
40:
36:
35:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3895:
3884:
3881:
3879:
3876:
3874:
3873:S100 proteins
3871:
3870:
3868:
3858:
3853:
3848:
3844:
3827:
3824:
3823:
3821:
3819:
3815:
3812:
3808:
3798:
3795:
3794:
3792:
3789:
3785:
3781:
3775:
3772:
3771:
3769:
3767:
3763:
3760:
3756:
3746:
3743:
3741:
3738:
3736:
3733:
3731:
3728:
3726:
3723:
3721:
3718:
3717:
3715:
3713:
3712:Breast cancer
3709:
3703:
3700:
3698:
3695:
3694:
3692:
3690:
3686:
3680:
3677:
3676:
3674:
3672:
3668:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3613:
3611:
3609:
3605:
3599:
3596:
3594:
3591:
3589:
3585:
3582:
3580:
3577:
3576:
3574:
3572:
3568:
3562:
3561:
3557:
3553:
3550:
3549:
3548:
3547:
3543:
3539:
3536:
3535:
3534:
3533:
3529:
3525:
3522:
3521:
3520:
3519:
3515:
3511:
3508:
3507:
3506:
3505:
3501:
3497:
3494:
3493:
3492:
3491:
3487:
3483:
3480:
3478:
3475:
3474:
3473:
3472:
3468:
3464:
3461:
3460:
3459:
3458:
3454:
3453:
3451:
3449:
3448:Ovarian tumor
3445:
3442:
3436:Reproductive/
3434:
3424:
3420:
3417:
3416:
3414:
3412:
3408:
3402:
3399:
3397:
3394:
3392:
3389:
3387:
3384:
3382:
3379:
3378:
3376:
3374:
3370:
3364:
3361:
3359:
3356:
3354:
3351:
3350:
3348:
3346:
3342:
3339:
3335:
3325:
3322:
3321:
3319:
3316:
3312:
3308:
3302:
3299:
3297:
3294:
3292:
3289:
3287:
3284:
3283:
3281:
3279:
3275:
3272:
3266:
3256:
3253:
3251:
3248:
3247:
3245:
3243:
3239:
3235:
3229:
3226:
3225:
3223:
3221:
3217:
3211:
3208:
3207:
3205:
3203:
3199:
3196:
3192:
3182:
3179:
3178:
3176:
3174:
3173:Neuroblastoma
3170:
3164:
3161:
3159:
3158:Synaptophysin
3156:
3155:
3153:
3151:
3147:
3141:
3138:
3136:
3133:
3132:
3130:
3128:
3124:
3117:
3114:
3112:
3108:
3105:
3103:
3102:Thyroglobulin
3100:
3099:
3097:
3095:
3091:
3088:
3084:
3074:
3071:
3069:
3066:
3065:
3063:
3061:
3060:Lymphosarcoma
3057:
3051:
3048:
3047:
3045:
3043:
3039:
3036:
3032:
3028:
3027:Tumor markers
3021:
3016:
3014:
3009:
3007:
3002:
3001:
2998:
2986:
2983:
2981:
2978:
2976:
2975:Synaptophysin
2973:
2969:
2966:
2964:
2961:
2959:
2956:
2955:
2954:
2951:
2947:
2944:
2943:
2942:
2939:
2937:
2934:
2932:
2929:
2927:
2924:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2902:
2899:
2897:
2894:
2892:
2889:
2887:
2884:
2880:
2877:
2875:
2872:
2871:
2870:
2867:
2865:
2862:
2860:
2857:
2856:
2854:
2850:
2844:
2841:
2839:
2836:
2834:
2831:
2830:
2828:
2826:
2822:
2818:
2814:
2807:
2802:
2800:
2795:
2793:
2788:
2787:
2784:
2772:
2769:
2767:
2764:
2762:
2759:
2757:
2756:C-type lectin
2754:
2752:
2749:
2747:
2744:
2743:
2741:
2739:
2734:
2724:
2721:
2720:
2718:
2716:
2712:
2704:
2701:
2699:
2696:
2694:
2691:
2689:
2686:
2685:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2638:
2637:
2634:
2633:
2631:
2628:
2624:
2621:
2619:
2614:
2604:
2601:
2599:
2596:
2594:
2591:
2589:
2586:
2585:
2583:
2579:
2571:
2568:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2526:
2523:
2522:
2521:
2518:
2517:
2515:
2513:
2508:
2502:
2499:
2495:
2492:
2490:
2487:
2483:
2480:
2478:
2475:
2473:
2470:
2468:
2465:
2464:
2463:
2460:
2458:
2455:
2454:
2453:
2450:
2449:
2447:
2445:
2440:
2434:
2431:
2429:
2426:
2424:
2421:
2419:
2416:
2415:
2413:
2411:
2406:
2398:
2395:
2393:
2390:
2389:
2388:
2385:
2383:
2380:
2378:
2375:
2371:
2368:
2366:
2363:
2361:
2358:
2356:
2353:
2351:
2348:
2346:
2343:
2341:
2338:
2336:
2333:
2331:
2328:
2326:
2323:
2321:
2318:
2317:
2316:
2313:
2311:
2308:
2306:
2305:Phospholamban
2303:
2301:
2298:
2294:
2291:
2289:
2286:
2284:
2281:
2279:
2276:
2272:
2269:
2267:
2264:
2263:
2262:
2259:
2257:
2254:
2252:
2249:
2248:
2247:
2244:
2242:
2239:
2237:
2234:
2232:
2231:Calsequestrin
2229:
2225:
2222:
2220:
2217:
2215:
2212:
2210:
2207:
2205:
2202:
2201:
2200:
2197:
2195:
2192:
2191:
2189:
2187:
2183:
2179:
2171:
2168:
2166:
2163:
2162:
2161:
2158:
2154:
2151:
2149:
2146:
2144:
2141:
2140:
2139:
2136:
2135:
2133:
2129:
2121:
2118:
2117:
2116:
2113:
2111:
2108:
2107:
2105:
2103:
2099:
2093:
2090:
2088:
2085:
2083:
2080:
2079:
2077:
2075:
2071:
2068:
2066:
2061:
2051:
2048:
2046:
2043:
2041:
2038:
2036:
2033:
2031:
2028:
2026:
2023:
2021:
2018:
2016:
2013:
2011:
2008:
2006:
2003:
2001:
1998:
1996:
1993:
1991:
1988:
1986:
1983:
1982:
1980:
1978:
1974:
1968:
1965:
1964:
1962:
1960:
1956:
1948:
1945:
1943:
1940:
1939:
1938:
1935:
1934:
1932:
1930:
1929:Calcium pumps
1926:
1918:
1915:
1913:
1910:
1908:
1905:
1904:
1903:
1900:
1896:
1893:
1891:
1888:
1886:
1883:
1881:
1878:
1876:
1873:
1872:
1871:
1870:Voltage-gated
1868:
1864:
1863:P2X receptors
1861:
1857:
1854:
1852:
1849:
1847:
1844:
1843:
1842:
1839:
1837:
1834:
1833:
1832:
1829:
1828:
1826:
1824:
1820:
1812:
1809:
1807:
1804:
1802:
1799:
1797:
1794:
1792:
1789:
1787:
1784:
1782:
1779:
1777:
1774:
1772:
1769:
1767:
1764:
1762:
1759:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1737:
1734:
1732:
1729:
1728:
1727:
1724:
1723:
1721:
1719:
1715:
1712:
1710:
1709:Cell membrane
1706:
1702:
1698:
1694:
1687:
1682:
1680:
1675:
1673:
1668:
1667:
1664:
1657:
1653:
1652:S100+Proteins
1650:
1649:
1645:
1639:
1635:
1630:
1625:
1621:
1617:
1613:
1609:
1605:
1600:
1596:
1592:
1587:
1582:
1578:
1574:
1570:
1566:
1562:
1557:
1553:
1549:
1544:
1539:
1535:
1531:
1527:
1523:
1519:
1514:
1510:
1506:
1501:
1496:
1493:(7): 1600–8.
1492:
1488:
1484:
1479:
1478:
1474:
1466:
1465:
1460:
1454:
1451:
1446:
1442:
1438:
1434:
1430:
1426:
1422:
1418:
1411:
1408:
1403:
1399:
1394:
1389:
1385:
1381:
1376:
1371:
1367:
1363:
1359:
1355:
1351:
1344:
1341:
1336:
1332:
1327:
1322:
1318:
1314:
1311:(4): 789–96.
1310:
1306:
1302:
1295:
1292:
1287:
1283:
1279:
1275:
1271:
1267:
1263:
1259:
1252:
1249:
1244:
1240:
1235:
1230:
1226:
1222:
1218:
1214:
1210:
1203:
1200:
1195:
1191:
1187:
1183:
1178:
1173:
1170:(6): 540–51.
1169:
1165:
1161:
1154:
1151:
1146:
1142:
1138:
1134:
1130:
1126:
1119:
1116:
1111:
1107:
1103:
1099:
1096:(5): 455–62.
1095:
1091:
1084:
1081:
1076:
1072:
1068:
1064:
1060:
1056:
1052:
1048:
1041:
1038:
1033:
1029:
1024:
1019:
1015:
1011:
1007:
1000:
997:
992:
988:
984:
980:
976:
972:
965:
962:
956:
952:
949:
947:
944:
943:
939:
937:
935:
931:
927:
923:
915:
911:
910:
905:
904:
899:
898:
893:
892:
887:
883:
882:
877:
876:
872:
869:
868:
863:
862:
857:
856:
851:
850:
845:
844:
840:
838:
837:
832:
831:
826:
825:
820:
819:
814:
813:
808:
807:
802:
801:
796:
795:
790:
789:
785:(psoriasin),
784:
783:
778:
777:
772:
771:
766:
765:
760:
759:
754:
753:
748:
747:
743:
742:
738:
736:
734:
730:
726:
722:
718:
714:
707:
706:paraganglioma
703:
699:
694:
687:
685:
681:
679:
676:
672:
671:keratinocytes
668:
664:
660:
656:
652:
648:
644:
640:
639:Schwann cells
636:
628:
626:
624:
620:
612:
610:
608:
604:
600:
599:
595:
591:
586:
582:
578:
574:
570:
566:
562:
558:
557:S100 proteins
543:
537:
533:
532:B:6-46
530:
524:
518:
514:A:10-19
512:
506:
500:
496:A:5-45
494:
488:
482:
478:A:5-46
476:
470:
464:
458:
452:
446:
440:
434:
428:
422:
416:
410:
406:A:5-46
404:
398:
392:
386:
380:
374:
370:B:4-47
368:
362:
356:
352:K:8-51
350:
344:
338:
334:A:4-47
332:
326:
320:
316:B:4-47
314:
308:
302:
298:A:4-47
296:
290:
284:
280:A:4-47
278:
272:
266:
262:B:4-47
260:
254:
248:
244:B:5-50
242:
236:
230:
226:B:5-50
224:
218:
212:
208:A:5-50
206:
200:
194:
189:B:9-52
187:
181:
175:
171:
169:
165:
162:
159:
157:
153:
150:
146:
142:
139:
137:
133:
129:
125:
122:
119:
115:
110:
106:
103:
99:
95:
92:
90:
86:
83:
80:
78:
74:
71:
68:
66:
62:
59:
56:
54:
50:
46:
42:
37:
30:
25:
20:
3558:
3544:
3538:Testosterone
3530:
3518:Dysgerminoma
3516:
3502:
3488:
3469:
3455:
3250:S100 protein
3249:
2941:S100 protein
2940:
2931:Neuropeptide
2668:Hemicentin 1
2418:Calreticulin
2376:
2310:Sarcalumenin
2110:IP3 receptor
1902:TRP channels
1831:Ligand-gated
1611:
1607:
1571:(1): 101–7.
1568:
1564:
1525:
1521:
1490:
1486:
1463:
1453:
1420:
1416:
1410:
1357:
1353:
1343:
1308:
1304:
1294:
1261:
1257:
1251:
1216:
1212:
1202:
1167:
1163:
1153:
1131:(3): 114–8.
1128:
1124:
1118:
1093:
1089:
1083:
1053:(1): 25–30.
1050:
1046:
1040:
1013:
1009:
999:
974:
970:
964:
951:Calprotectin
919:
916:Nomenclature
907:
901:
895:
889:
885:
879:
873:
865:
859:
853:
847:
841:
834:
828:
822:
816:
810:
804:
798:
792:
786:
780:
774:
768:
762:
756:
750:
744:
725:histiocytoma
710:
700:marking the
682:
647:chondrocytes
635:neural crest
632:
616:
597:
593:
589:
584:
556:
554:
526:B:5-48
520:A:8-51
508:A:10-19
502:B:7-50
490:B:5-45
472:A:5-46
460::5-46
454:A:5-46
448:A:5-46
442::5-46
430:A:5-46
424::5-46
418:A:5-46
412:A:5-46
394:B:5-46
388::5-46
382:A:5-46
364:D:4-47
358:I:4-47
346:H:8-51
340:A:5-48
328:A:4-47
322:A:4-47
310:B:4-47
304:B:4-47
292:B:4-47
286:B:4-47
268:A:4-47
256:B:5-48
250:A:5-48
238:B:5-50
232:A:5-50
220:A:5-50
214:A:5-50
202:A:5-50
196:A:9-52
190:
183:A:9-52
177:B:9-52
3797:Cytokeratin
3735:Cathepsin D
3324:Factor VIII
3315:endothelium
3278:Lung cancer
3270:respiratory
3220:Astrocytoma
3202:Brain tumor
2946:Calgranulin
2921:Neurogranin
2723:Osteocalcin
2703:Osteopontin
2678:Osteonectin
2452:CaM kinases
2300:Parvalbumin
2283:Neurocalcin
2278:Hippocalcin
1467:, Elsevier.
1305:Amino Acids
924:at neutral
739:Human genes
717:schwannomas
698:immunostain
659:macrophages
643:melanocytes
565:vertebrates
539::6-46
484::4-46
466::5-46
436::5-46
400::5-46
376::5-46
274::4-47
39:Identifiers
3867:Categories
3788:epithelium
3111:Calcitonin
3050:Neprilysin
2771:Gla domain
2588:Calcitonin
2410:chaperones
2387:Troponin C
2251:Calsenilin
2236:Calretinin
2199:Calmodulin
957:References
932:, such as
715:, 100% of
651:adipocytes
623:calmodulin
619:calmodulin
124:structures
3784:Carcinoma
3337:Digestive
3291:Enolase 2
3140:Enolase 2
3086:Endocrine
2825:Synuclein
2746:C2 domain
2618:chelators
2603:Vitamin K
2598:Vitamin D
2512:proteases
2288:Recoverin
2256:Frequenin
2194:Calbindin
2186:chelators
2065:signaling
1726:Cadherins
1437:1090-2104
1384:1932-6203
713:melanomas
688:Pathology
613:Structure
563:found in
82:PDOC00275
70:IPR013787
3774:Vimentin
3740:CA 27-29
3438:urinary/
3242:Melanoma
3042:Lymphoma
2953:Synapsin
2864:Chimerin
2751:Cadherin
2683:SIBLINGs
2636:Fibulins
2629:proteins
2520:Calpains
2423:Calnexin
2241:Gelsolin
1977:Annexins
1638:21148126
1595:19136201
1552:18606705
1509:16528363
1459:Elsevier
1445:25450399
1402:25084534
1354:PLOS ONE
1335:20596736
1286:22907221
1278:18547346
1243:18606705
1194:37798037
1186:12645002
1075:70911084
1032:26416282
991:15336958
940:See also
561:proteins
141:RCSB PDB
65:InterPro
3857:Biology
3766:Sarcoma
3720:CA 15-3
3656:TMPRSS2
3552:Inhibin
2980:Tubulin
2813:Protein
2761:EF hand
2738:domains
2444:kinases
2433:HSP90B1
2293:Visinin
2182:Sensors
2170:SLC24A5
1629:6334290
1586:2680177
1543:2435511
1393:4118983
1362:Bibcode
1326:6410564
1234:2435511
1145:7548432
1110:9596268
1067:2002421
836:S100A16
830:S100A14
824:S100A13
818:S100A12
812:S100A11
806:S100A10
788:S100A7A
577:EF-hand
569:calcium
77:PROSITE
58:PF01023
3843:Portal
3826:Desmin
3641:SPINK1
3588:AFP-L3
3463:CA-125
3440:breast
3423:AFP-L3
3391:CA 242
3381:CA19-9
3353:CA19-9
2901:Myelin
2869:Granin
2570:CAPN10
2224:CALML5
2219:CALML3
2165:SLC8B1
2153:ATP2A3
2148:ATP2A2
2143:ATP2A1
1947:SLC8A1
1942:SLC3A2
1658:(MeSH)
1636:
1626:
1593:
1583:
1550:
1540:
1507:
1443:
1435:
1400:
1390:
1382:
1333:
1323:
1284:
1276:
1241:
1231:
1192:
1184:
1143:
1108:
1073:
1065:
1030:
989:
800:S100A9
794:S100A8
782:S100A7
776:S100A6
770:S100A5
764:S100A4
758:S100A3
752:S100A2
746:S100A1
727:, and
675:breast
669:, and
641:, and
598:S100A3
594:S100A2
590:S100A1
545:A:6-46
156:PDBsum
130:
120:
102:SUPFAM
44:Symbol
3745:hPG80
3702:NMP22
3679:NANOG
3661:hPG80
3646:GOLM1
3598:hPG80
3560:hPG80
3401:hPG80
3363:hPG80
3301:hPG80
3073:CD79a
3034:Blood
2985:GPM6A
2896:GLUT3
2859:Agrin
2852:Other
2661:FBLN5
2656:FBLN4
2651:FBLN3
2646:FBLN2
2641:FBLN1
2565:CAPN9
2560:CAPN8
2555:CAPN7
2550:CAPN6
2545:CAPN5
2540:CAPN4
2535:CAPN3
2530:CAPN2
2525:CAPN1
2494:CAMK4
2489:CAMK3
2462:CAMK2
2457:CAMK1
2428:HSPA5
2397:TNNC2
2392:TNNC1
2382:S100P
2370:SYT14
2365:SYT13
2360:SYT11
2214:CALM3
2209:CALM2
2204:CALM1
2138:SERCA
2092:cADPR
2087:NAADP
2025:A8-L2
1959:GPCRs
1811:CDH17
1806:CDH16
1801:CDH15
1796:CDH14
1791:CDH13
1786:CDH12
1781:CDH11
1776:CDH10
1282:S2CID
1190:S2CID
1071:S2CID
909:THHL1
867:S100Z
861:S100Z
855:S100P
849:S100G
843:S100B
704:in a
696:S100
581:genes
98:SCOPe
89:SCOP2
47:S_100
3651:PCA3
3593:CD30
3579:βhCG
3477:CD30
3210:PCNA
2916:SCG5
2886:FMR1
2377:S100
2355:SYT9
2350:SYT7
2345:SYT6
2340:SYT5
2335:SYT4
2330:SYT3
2325:SYT2
2320:SYT1
2261:GUCA
2184:and
1917:TRPV
1912:TRPC
1907:TRPA
1771:CDH9
1766:CDH8
1761:CDH7
1756:CDH6
1751:CDH5
1746:CDH4
1741:CDH3
1736:CDH2
1731:CDH1
1699:and
1634:PMID
1591:PMID
1548:PMID
1505:PMID
1441:PMID
1433:ISSN
1398:PMID
1380:ISSN
1331:PMID
1274:PMID
1239:PMID
1182:PMID
1141:PMID
1106:PMID
1063:PMID
1028:PMID
987:PMID
903:TCHH
897:RPTN
891:HRNR
886:FLG2
875:CRNN
585:S100
555:The
542:3psr
536:2psr
529:1psr
523:1mr8
517:1qls
511:1v50
505:1v4z
499:1nsh
493:1bt6
487:1a4p
481:1cb1
475:1d1o
469:1igv
463:4icb
457:1cdn
451:1ksm
445:1kqv
439:3icb
433:1boc
427:1n65
421:2bcb
415:1ht9
409:1kcy
403:1b1g
397:1bod
391:1qx2
385:2bca
379:1ig5
373:1clb
367:1e8a
361:1odb
355:1gqm
349:1xk4
343:1irj
337:1kso
331:1ozo
325:1j55
319:1mwn
313:1dt7
307:1xyd
301:1qlk
295:1sym
289:1b4c
283:1mq1
277:1uwo
271:1mho
265:1psb
259:1cfp
253:1k2h
247:1m31
241:1jwd
235:2cnp
229:1a03
223:1cnp
217:1k9k
211:1k96
205:1k9p
199:1k8u
193:1yur
186:1yus
180:1yuu
174:1yut
149:PDBj
145:PDBe
128:ECOD
118:Pfam
94:1cnp
53:Pfam
3546:GCT
3524:LDH
3510:hCG
3490:EST
3482:hCG
3068:CD3
2082:IP3
2050:A13
2045:A12
2040:A11
2035:A10
1624:PMC
1616:doi
1581:PMC
1573:doi
1569:277
1538:PMC
1530:doi
1526:181
1495:doi
1491:126
1425:doi
1421:454
1388:PMC
1370:doi
1321:PMC
1313:doi
1266:doi
1229:PMC
1221:doi
1217:181
1172:doi
1133:doi
1098:doi
1055:doi
1051:163
1018:doi
1014:195
979:doi
975:322
881:FLG
645:),
168:PDB
136:PDB
3869::
3471:EC
3238:NC
2815::
2271:1B
2266:1A
2030:A9
2020:A8
2015:A7
2010:A6
2005:A5
2000:A4
1995:A3
1990:A2
1985:A1
1695::
1632:.
1622:.
1610:.
1606:.
1589:.
1579:.
1567:.
1563:.
1546:.
1536:.
1524:.
1520:.
1503:.
1489:.
1485:.
1461:,
1439:.
1431:.
1419:.
1396:.
1386:.
1378:.
1368:.
1356:.
1352:.
1329:.
1319:.
1309:41
1307:.
1303:.
1280:.
1272:.
1262:35
1260:.
1237:.
1227:.
1215:.
1211:.
1188:.
1180:.
1168:60
1166:.
1162:.
1139:.
1129:70
1127:.
1104:.
1094:29
1092:.
1069:.
1061:.
1049:.
1026:.
1012:.
1008:.
985:.
973:.
926:pH
906:,
900:,
894:,
888:,
884:,
878:,
858:,
852:,
846:,
833:,
827:,
815:,
809:,
779:,
773:,
767:,
761:,
755:,
749:,
735:.
680:.
665:,
661:,
657:,
653:,
649:,
596:,
592:,
575:("
147:;
143:;
126:/
100:/
96:/
3845::
3790:)
3786:(
3586:/
3421:/
3317:)
3313:(
3240:/
3118:)
3109:(
3019:e
3012:t
3005:v
2968:3
2963:2
2958:1
2879:B
2805:e
2798:t
2791:v
2482:G
2477:D
2472:B
2467:A
1895:T
1890:R
1885:P
1880:N
1875:L
1685:e
1678:t
1671:v
1640:.
1618::
1612:2
1597:.
1575::
1554:.
1532::
1511:.
1497::
1447:.
1427::
1404:.
1372::
1364::
1358:9
1337:.
1315::
1288:.
1268::
1245:.
1223::
1196:.
1174::
1147:.
1135::
1112:.
1100::
1077:.
1057::
1034:.
1020::
993:.
981::
870:)
864:(
637:(
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