1113:"O'Rahilly, Sir Stephen (Patrick), (born 1 April 1958), Professor of Clinical Biochemistry and Medicine (formerly Professor of Metabolic Medicine), Departments of Medicine and Clinical Biochemistry, since 1996, Head, Clinical Biochemistry Department, since 2002, and Director, Institute of Metabolic Science, Metabolic Research Laboratories, since 2007, University of Cambridge; Fellow of Pembroke College, Cambridge, since 2007; Hon. Consultant Physician, Addenbrooke's Hospital, since 1994; Director, MRC Metabolic Diseases Unit (formerly MRC Centre for Obesity and Related Metabolic Diseases), since 2007; Scientific Director, NIHR Cambridge Biomedical Research Centre, since 2010"
1236:
80:
1249:
Loos, R. J.; Lindgren, C. M.; Li, S; Wheeler, E; Zhao, J. H.; Prokopenko, I; Inouye, M; Freathy, R. M.; Attwood, A. P.; Beckmann, J. S.; Berndt, S. I.; Prostate, Lung; Jacobs, K. B.; Chanock, S. J.; Hayes, R. B.; Bergmann, S; Bennett, A. J.; Bingham, S. A.; Bochud, M; Brown, M; Cauchi, S; Connell, J.
919:
Seminara, S. B.; Messager, S.; Chatzidaki, E. E.; Thresher, R. R.; Acierno, J. S.; Shagoury, J. K.; Bo-Abbas, Y.; Kuohung, W.; Schwinof, K. M.; Hendrick, A. G.; Zahn, D.; Dixon, J.; Kaiser, U. B.; Slaugenhaupt, S. A.; Gusella, J. F.; O'Rahilly, S.; Carlton, M. B. L.; Crowley, W. F.; Aparicio, S. A.
439:
where he is a
Professor of Clinical Biochemistry and Medicine, Director of the Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories, Director of the MRC Metabolic Diseases Unit and co-director of the Wellcome-MRC Institute of Metabolic Science. He is also the scientific
1009:
Payne, F.; Lim, K.; Girousse, A.; Brown, R. J.; Kory, N.; Robbins, A.; Xue, Y.; Sleigh, A.; Cochran, E.; Adams, C.; Dev Borman, A.; Russel-Jones, D.; Gorden, P.; Semple, R. K.; Saudek, V.; O'Rahilly, S.; Walther, T. C.; Barroso, I.; Savage, D. B. (2014).
516:
and have identified a subtype of obesity amenable to dramatically effective therapy. His studies of patients with extreme insensitivity to insulin have also provided new insights into human insulin action and its disruption in states of insulin
1299:
507:
Stephen O'Rahilly has made major contributions to the understanding of the molecular mechanisms underlying human disorders of energy balance and metabolism. His work first established that mutations in single genes could result in severe human
1948:
1938:
1303:
2008:
588:
In 2023, O'Rahilly was awarded the OU Health Harold Hamm
International Prize for Biomedical Research in Diabetes for his outstanding research into the link between obesity and Type 2 diabetes.
862:; Whitehead, J. P.; Soos, M. A.; Rau, H.; Wareham, N. J.; Sewter, C. P.; Digby, J. E.; Mohammed, S. N.; Hurst, J. A.; Cheetham, C. H.; Earley, A. R.; Barnett, A. H.; Prins, J. B. (1997).
1175:
Roberts, E. W.; Deonarine, A; Jones, J. O.; Denton, A. E.; Feig, C; Lyons, S. K.; Espeli, M; Kraman, M; McKenna, B; Wells, R. J.; Zhao, Q; Caballero, O. L.; Larder, R; Coll, A. P.;
1958:
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347:
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53:
1953:
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O’Rahilly lives in
Cambridge, England with his wife, journalist Philippa Lamb, and his stepson Felix Lamb. He was married to Suzy Oakes from 1990 until her death in 2011.
754:
Gerken, T.; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.;
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1998:
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and that these defects largely acted through disruption of central satiety mechanisms. These findings have altered clinical approaches to the evaluation of the
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2003:
2018:
2013:
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1193:"Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia"
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69:
966:; Jebb, S. A.; Langmack, G.; Lawrence, E.; Cheetham, C. H.; Prentice, A. M.; Hughes, I. A.; McCamish, M. A.; O'Rahilly, S. (1999).
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1012:"Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease"
1702:
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1933:
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in 2011 by the Royal
College of Physicians. He was awarded it again, by the Royal Society in 2022, this time jointly with
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M.; Cooper, C; Smith, G. D.; Day, I; Dina, C; De, S; Dermitzakis, E. T.; Doney, A. S.; et al. (2008).
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555:. In 2018, he was made an Honorary Doctor of RCSI University of Medicine and Health Sciences in Dublin.
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1070:"Professor Steve O'Rahilly, Head of Department and Professor of Clinical Biochemistry and Medicine"
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784:"The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase"
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707:"Translating metabolic biochemistry into the clinic: An interview with Steve O'Rahilly"
706:
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864:"Congenital leptin deficiency is associated with severe early-onset obesity in humans"
459:
Notable
Cambridge scientists with whom O'Rahilly has shared paper authorship include
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767:
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220:
1541:"2023 OU Health Harold Hamm International Prize for Biomedical Research in Diabetes"
1252:"Common variants near MC4R are associated with fat mass, weight and risk of obesity"
968:"Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency"
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1144:"Stephen O'Rahilly, University of Cambridge Metabolic Research Laboratories"
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897:
1486:"RCSI celebrates graduation of 900 healthcare and research professionals"
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376:
1336:"Professor Stephen O'Rahilly wins the 2010 InBev-Baillet Latour Prize"
444:(NIHR) Cambridge Biomedical Research Centre, Associate Faculty at the
1515:
2019 Banting Medal for
Scientific Achievement - Stephen O'Rahilly, MD
842:
673:
545:
411:(MB BCh BAO) degrees. He later continued his studies and completed a
396:
208:
103:
1267:
888:
863:
409:
Bachelor of
Medicine, Bachelor of Surgery, Bachelor of Obstetrics
1586:
548:
in the 2013 Birthday
Honours for services to medical research.
758:; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.;
399:, Ireland. He was educated at Beneavin De La Salle College in
36:
1567:"Irish research scientist to be knighted by Queen Elizabeth"
558:
In 2019, O'Rahilly was elected as an
Honorary Fellow of the
1949:
Fellows of the
Academy of Medical Sciences (United Kingdom)
371:
and scientist known for his research into the molecular
566:
for his contributions towards diabetes research by the
1939:
Foreign associates of the National Academy of Sciences
2009:
Fellows of the Royal College of Physicians of Ireland
1162:"NIHR Cambridge Biomedical Research Centre Web Site"
1859:
1628:
305:
247:
237:
166:
140:
121:
111:
86:
34:
623:
27:Irish-British physician and scientist (born 1958)
1016:Proceedings of the National Academy of Sciences
505:
442:National Institute for Health and Care Research
1598:
599:He holds dual Irish and British citizenship.
452:, Cambridge. He is a professorial fellow of
8:
1959:Fellows of the Royal College of Pathologists
1460:"18 New Members of the Royal Irish Academy"
1302:. London: The Royal Society. Archived from
1085:
1083:
1954:Fellows of the Royal College of Physicians
1605:
1591:
1583:
1121:. Oxford University Press. 1 December 2022
78:
31:
1505:The Learned Society of Wales, 20 May 2019
1351:
1275:
1218:
1072:. University of Cambridge. Archived from
1045:
1035:
985:
939:
887:
815:
730:
681:
618:
616:
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612:
581:and they presented their lecture at the
423:O'Rahilly undertook research into Type 2
1378:. University of Debrecen. Archived from
1300:"EC/2003/27: O'Rahilly, Stephen Patrick"
1107:
1105:
1103:
922:"TheGPR54Gene as a Regulator of Puberty"
367:(born 1 April 1958) is an Irish-British
1974:Irish expatriates in the United Kingdom
1376:"Debrecen Award for Molecular Medicine"
658:"A conversation with Stephen O'Rahilly"
608:
159: 1990; died 2011)
1999:Fellows of Pembroke College, Cambridge
1436:(Supplement). 15 June 2013. p. 1.
1138:
1136:
638: ed.). A & C Black.
395:O'Rahilly was born on 1 April 1958 in
858:Oʼrahilly, Stephen; Montague, C. T.;
539:Royal College of Physicians of London
531:Debrecen Award for Molecular Medicine
448:and honorary consultant physician at
215:Debrecen Award for Molecular Medicine
7:
1994:21st-century British medical doctors
1989:20th-century British medical doctors
1490:Royal College of Surgeons in Ireland
839:Stephen O'Rahilly's publications
2004:Alumni of University College Dublin
551:In 2017, he became a member of the
2019:Medical doctors from County Dublin
2014:Members of the Royal Irish Academy
1984:21st-century Irish medical doctors
1979:20th-century Irish medical doctors
1402:"Harveian Oration and dinner 2016"
25:
662:Journal of Clinical Investigation
527:InBev-Baillet Latour Health Prize
403:, Dublin. He studied medicine at
191:InBev-Baillet Latour Health Prize
1529:The Royal Society, 14 April 2022
1234:
1198:Journal of Experimental Medicine
562:(LSW). He was also awarded the
1517:, ADA Diabetes Pro, 20 May 2019
1340:Disease Models & Mechanisms
973:New England Journal of Medicine
927:New England Journal of Medicine
920:J. R.; Colledge, W. H. (2003).
711:Disease Models & Mechanisms
533:in 2014. He delivered the 2016
503:in 2003. His nomination reads:
446:Wellcome Trust Sanger Institute
327:/professor-sir-stephen-orahilly
156:
1539:McIntosh, Kate (7 June 2023).
427:and insulin resistance at the
1:
1929:Scientists from County Dublin
762:; Sedgwick, B.; Barroso, I.;
568:American Diabetes Association
495:O'Rahilly was elected to the
336:Sir Stephen Patrick O'Rahilly
1964:Fellows of the Royal Society
1565:Keenan, Dan (15 June 2013).
643:UK public library membership
987:10.1056/NEJM199909163411204
497:Academy of Medical Sciences
454:Pembroke College, Cambridge
260:Pembroke College, Cambridge
2035:
1527:Croonian Medal and Lecture
1447:Stephen O'Rahilly knighted
1406:Royal College of Physician
625:"O'RAHILLY, Prof. Stephen"
573:O'Rahilly was awarded the
407:, graduating in 1981 with
383:and related metabolic and
1969:NIHR Senior Investigators
634:. Vol. 2015 (online
405:University College Dublin
301:
283:St Bartholomew's Hospital
274:University College Dublin
230:
126:University College Dublin
77:
18:Stephen Patrick O’Rahilly
1765:Richard John Nelmes
1449:, BBC News, 14 June 2013
1322:12 November 2013 at the
845:bibliographic database.
560:Learned Society of Wales
391:Early life and education
325:/principal-investigators
1037:10.1073/pnas.1408523111
847:(subscription required)
808:10.1126/science.1151710
636:Oxford University Press
437:University of Cambridge
255:University of Cambridge
1814:Richard H. Sibson
1808:John Donald Scott
1657:John Milton Brown
1317:Heinrich Wieland Prize
523:Heinrich Wieland Prize
519:
450:Addenbrooke's Hospital
433:Harvard Medical School
278:Addenbrooke's Hospital
270:Harvard Medical School
180:Heinrich Wieland Prize
1801:John Gair Robson
656:Neill, U. S. (2013).
435:, before joining the
415:(MD) degree in 1987.
41:Stephen O'Rahilly
1934:Irish diabetologists
1745:Jonathan D. G. Jones
1641:Jocelyn Bell Burnell
1503:LSW Honorary Fellows
1211:10.1084/jem.20122344
1089:Ellen Ruppel Shell,
941:10.1056/NEJMoa035322
429:University of Oxford
293:Hammersmith Hospital
265:University of Oxford
1795:Elizabeth Robertson
1739:Malcolm Irving
1703:Roger Fletcher
1492:. 15 November 2018.
1464:Royal Irish Academy
1382:on 13 December 2014
1028:2014PNAS..111.8901P
880:1997Natur.387..903M
800:2007Sci...318.1469G
794:(5855): 1469–1472.
705:Weston, K. (2011).
553:Royal Irish Academy
521:He was awarded the
1880:Klaus von Klitzing
1874:Fotis Kafatos
1830:Adrian Sutton
1790:Venki Ramakrishnan
1728:Peter Holland
1433:The London Gazette
1353:10.1242/dmm.006080
1346:(7–8): 402. 2010.
1187:; Tuveson, D. A.;
723:10.1242/dmm.007641
570:in the same year.
491:Awards and honours
477:Antonio Vidal-Puig
461:Krishna Chatterjee
413:Doctor of Medicine
381:insulin resistance
1906:
1905:
1898:Valentine Telegdi
1886:Donald Knuth
1851:Peter N. T. Wells
1824:Geoffrey L. Smith
1770:Stephen O'Rahilly
1760:Stephen Mann
1698:Jeffery Errington
1678:Anthony Dickinson
1095:Discover Magazine
1076:on 13 April 2014.
1022:(24): 8901–8906.
641:(Subscription or
333:
332:
232:Scientific career
16:(Redirected from
2026:
1944:Knights Bachelor
1750:Michael L. Klein
1733:James Hough
1663:Mark Wayne Chase
1651:William Bonfield
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1306:on 13 July 2015.
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1185:Teichmann, S. A.
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1150:on 14 June 2014.
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674:10.1172/JCI70726
668:(6): 2335–2336.
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535:Harveian Oration
529:in 2010 and the
440:Director of the
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874:(6636): 903–8.
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841:indexed by the
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772:Ashcroft, F. M.
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1408:. 27 June 2016
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1268:10.1038/ng.140
1241:
1205:(6): 1137–51.
1181:Brindle, K. M.
1167:
1153:
1132:
1118:Who's Who 2023
1099:
1079:
1061:
1001:
980:(12): 879–84.
955:
911:
860:Farooqi, I. S.
850:
831:
768:Ponting, C. P.
760:Farooqi, I. S.
746:
717:(2): 141–144.
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648:
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590:
575:Croonian Medal
544:O'Rahilly was
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1892:José Sarukhán
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1718:Peter Green
1693:Ann Dowling
1470:27 November
1428:"No. 60534"
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209:Knighthood
203:Baly Medal
186:FRS (2003)
146:Suzy Oakes
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585:in 2022.
485:Giles Yeo
385:endocrine
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