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Proteins form Binary
Complexes with Hsp90 and Ternary Complexes with Hsp90 and Hsp70. Wickramaratne AC, Liao JY, Doyle SM, Hoskins JR, Puller G, Scott ML, Alao JP, Obaseki I, Dinan JC, Maity TK, Jenkins LM, Kravats AN, Wickner S. J Mol Biol. 435(17): 168-184,
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Wickramaratne AC, Wickner S, Kravats AN. Hsp90, a team player in protein quality control and the stress response in bacteria. Microbiol Mol Biol Rev. 2024 Jun 27;88(2):e0017622. doi: 10.1128/mmbr.00176-22. Epub 2024 Mar 27. PMID: 38534118; PMCID:
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O.Genest, M. Reidy, T.O. Street, J.R.Hoskins, J.L.Camberg, D.A.Agard, D.C. Masison, and S.Wickner (2013) “ Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast.”
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130:, proteins that regulate most cellular processes including replication and transcription and response to stress. Chaperones function to alter activity, refold as well as degrade proteins. Her citation from election to the
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M. Miot. M. Reidy, S.M. Doyle, J.R. Hoskins, D.M. Johnston, O. Genest, M.C.Vitery, D.C. Masison, and S. Wickner (2011) “Species-specific collaboration of heat shock proteins (Hsp)70 and 100 in thermotolerance and protein
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once their signals have been delivered. Since there are some human diseases that result from abnormally folded and/or aggregated proteins, these ATP-dependent chaperones are important in disease treatment development.
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Wickner S, Nguyen TL, Genest O. The
Bacterial Hsp90 Chaperone: Cellular Functions and Mechanism of Action. Annu Rev Microbiol. 2021 Oct 8;75:719-739. doi: 10.1146/annurev-micro-032421-035644. Epub 2021 Aug 10. PMID:
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O. Genest, J.R.Hoskins, J.L.Camberg, S.M.Doyle, and S. Wickner (2011) “Heat shock protein 90 from
Escherichia coli collaborates with the DnaK chaperone system in client protein remodeling.
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Wickramaratne A, Wickner S. Diptoindonesin G, a new Hsp90 drug. J Biol Chem. 2023 Jan;299(1):102826. doi: 10.1016/j.jbc.2022.102826. Epub 2022 Dec 23. PMID: 36572186; PMCID: PMC9841029.
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A. N. Kravats, S. M. Doyle, J.R. Hoskins, O.Genest, E, Doody, S. Wickner (2017) “Interaction of E. coli Hsp90 with DnaK involves the DnaJ binding region of DnaK.
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78:, then joined the Laboratory of Molecular Biology at the National Cancer Institute. She did a sabbatical with Fred Sanger at the MRC in Cambridge UK in 1983.
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Genest O, Wickner S, Doyle SM. (2019) "Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling." J Biol Chem. 294(6):2109-2120.
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S. M. Doyle, O. Genest, and S. Wickner (2013) “Protein rescue from aggregates by powerful molecular chaperone machines.”
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Structure And Action Of
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genes of the phage. At NIH, her research has illuminated the action of proteins that utilize
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replicative form in the test tube and that the reaction required the gene products of
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Operators and
Promoters:The Story of Molecular Biology and Its Creators
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notes her most recent contributions to ATP-dependent chaperones for
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Fellows of the
American Association for the Advancement of Science
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by removing proteins that folded incorrectly and how they degrade
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of
Yeshiva University. Her dissertation advisor there was
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and is located in the Center for Cancer
Research (NCI/CCR).
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who is a distinguished investigator and the head of the DNA
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Members of the United States
National Academy of Sciences
138:(protein breakdown), showing how they participate in
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Wickner at the
National Institutes of Health in 1995
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American Association for the Advancement of Science
90:and Jerry Hurwitz published an early paper showing
159:American Academy of Arts and Science Member, 2002
371:. University of California Press, Berkeley, CA.
275:S. Wickner (1978) “DNA Replication Proteins of
86:Sue Wickner and her coauthors Michel Wright,
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94:in the test tube. They found that the
464:Albert Einstein College of Medicine alumni
156:National Academy of Sciences Member, 2004
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484:21st-century American women scientists
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68:Albert Einstein College of Medicine
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16:American biochemist and geneticist
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58:Sue earned the B.S. degree from
444:American women microbiologists
318:Albert Einstein Medical School
46:. Her laboratory is under the
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439:American molecular biologists
348:National Institutes of Health
44:National Institutes of Health
459:Georgetown University alumni
397:National Academy of Sciences
222:Journal of Molecular Biology
132:National Academy of Sciences
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454:American University alumni
434:American women geneticists
48:National Cancer Institute
266:Proc Natl Acad Sci U S A
102:could be converted from
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124:adenosine triphosphate
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393:"Sue Hengren Wickner"
367:H. G. Echols. (2001)
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64:Georgetown University
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429:American geneticists
128:molecular chaperones
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144:regulatory proteins
60:American University
28:Sue Hengren Wickner
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151:Honors and awards
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136:proteolysis
418:Categories
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36:geneticist
32:biochemist
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98:or phage
54:Education
100:Phi X174
82:Research
106:to the
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170:Books
404:2018
373:ISBN
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325:2018
186:ISBN
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