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laboratory at the
University of Pennsylvania. As well as investigating potential antivirals, the Weiss laboratory are studying the evolution of SARS-CoV-2. Work during the SARS-CoV-2/COVID-19 pandemic includes identification of SARS-CoV-2 in domestic cats, the innate immune response to SARS-CoV-2
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coronavirus disease without being aware that they have it. Whereas in the case of SARS, patients were too unwell to leave their homes, so they tended to self-isolate, and the virus was most transmissible from severely ill patients rather than asymptomatic ones. In March 2020, Weiss was awarded
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Holmes, Edward C.; Goldstein, Stephen A.; Rasmussen, Angela L.; Robertson, David L.; Crits-Christoph, Alexander; Wertheim, Joel O.; Anthony, Simon J.; Barclay, Wendy S.; Boni, Maciej F.; Doherty, Peter C.; Farrar, Jeremy (2021-09-16).
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in mouse hepatitis virus-induced disease. Despite murine coronavirus being a useful model of coronaviruses, it is still unclear how mouse hepatitis virus is spread. There is only one receptor for the mouse hepatitis virus – the
1236:
Li, Yize; Renner, David M.; Comar, Courtney E.; Whelan, Jillian N.; Reyes, Hanako M.; Cardenas-Diaz, Fabian
Leonardo; Truitt, Rachel; Tan, Li Hui; Dong, Beihua; Alysandratos, Konstantinos Dionysios; Huang, Jessie (2021-04-20).
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effects of nucleic acid sequences. She looks to understand what determines coronavirus viral and cellular tropism, as well as better understanding the pathogenesis of coronavirus in the brain. This has involved studies of the
223:. These coronaviruses have all evolved to shut down immune responses but have different accessory proteins. Coronaviruses are complex viruses that circulate in animals and occasionally infect humans. They have the largest
303:, become a centralized repository of SARS-CoV-2 research and create new opportunities to fund research relating to SARS-CoV-2. SARS-CoV-2 is different to SARS; as there are many people who have mild or
140:
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Ku Z, Xie X, Davidson E, Ye X, Su H, Menachery VD, Li Y, Yuan Z, Zhang X, Muruato AE, I Escuer AG, Tyrell B, Doolan K, Doranz BJ, Wrapp D, Bates PF, McLellan JS, Weiss SR, Zhang N, Shi PY, An Z.
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Lenz, Olivia C.; Marques, Andrew D.; Kelly, Brendan J.; Rodino, Kyle G.; Cole, Stephen D.; Perera, Ranawaka A. P. M.; Weiss, Susan R.; Bushman, Frederic D.; Lennon, Elizabeth M. (2022-02-17).
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genome of any viruses, which indicates that they have a wide array of proteins that can attack host cells. Whilst MERS has a viral reservoir in
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279:) immune pathway. Weiss has considered the mechanisms by which the phosphodiesterase antagonizes Ribonuclease L. She has studied the role of
453:"The Group-Specific Murine Coronavirus Genes Are Not Essential, but Their Deletion, by Reverse Genetics, Is Attenuating in the Natural Host"
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143:. She holds vice chair positions for the Department of Microbiology and for Faculty Development. Her research considers the biology of
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1239:"SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes"
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872:"Susan R. Weiss | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of Pennsylvania"
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camel handlers, SARS does not have such a specific reservoir. Coronaviruses that occur in humans are primarily viruses of the
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Center of
Research for Coronaviruses and Other Emerging Pathogens. The Center looks to accelerate research that focuses on
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Penn
Medicine Lecture on Coronaviruses: History, Replication and Innate Immune Antagonism on YouTube, April 3, 2020
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591:"Susan R. Weiss | Department of Microbiology | Perelman School of Medicine at the University of Pennsylvania"
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Weiss began to work on coronaviruses in the 1980s, when the field was relatively new. She makes use of the
191:. At the time, very little was known about the impact of coronaviruses, other than that they can cause the
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de Haan, Cornelis A.M.; Masters, Paul S.; Shen, Xiaolan; Weiss, Susan; Rottier, Peter J.M. (2002-04-25).
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347:"Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus"
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Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape.
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or MHV) to develop mouse models that allow the study of various pathologies, including
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Salata, Cristiano; Calistri, Arianna; Parolin, Cristina; PalĂą, Giorgio (2019-12-01).
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infection, and critical reviews of scientific evidence for the origin of SARS-CoV-2.
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662:"Penn microbiologist explains why some coronaviruses are more deadly than others"
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163:/Penn Medicine Center for Research on Coronavirus and Other Emerging Pathogens.
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1004:"Scientometric Trends for Coronaviruses and Other Emerging Viral Infections"
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807:"How Coronaviruses Cause Infection—from Colds to Deadly Pneumonia"
758:"As many labs go quiet, research to find a coronavirus therapy ramps up"
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Weiss attended
Roosevelt High School. She eventually studied biology at
89:
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782:"The Biology of Coronaviruses: From the Lab to the Spotlight – PR News"
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615:"Penn Center for Research on Coronavirus and Other Emerging Pathogens"
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Perelman School of
Medicine at the University of Pennsylvania faculty
1121:"What we've learned about the coronavirus — and what we need to know"
83:
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Yount, B.; Denison, M. R.; Weiss, S. R.; Baric, R. S. (2002-11-01).
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Weiss' work and expertise has been featured in the science podcast
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helps to understand the function of a gene through the analysis of
203:
Weiss' coronavirus research has encompassed the emerging pathogens
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923:"Murine coronavirus neuropathogenesis: determinants of virulence"
1179:"SARS-CoV-2 Delta Variant (AY.3) in the Feces of a Domestic Cat"
152:
148:
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Analysis of
Newcastle disease virus messenger RNA and poly (A)
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antagonists that are encoded by the coronavirus, specifically
224:
90:
Analysis of
Newcastle disease virus messenger RNA and poly (A)
1002:
Kagan, Dima; Moran-Gilad, Jacob; Fire, Michael (2020-03-20).
979:"The biology of coronaviruses: From the lab to the spotlight"
695:"Coronaviruses: a paradigm of new emerging zoonotic diseases"
141:
Perelman School of
Medicine at the University of Pennsylvania
73:
Perelman School of
Medicine at the University of Pennsylvania
1072:"Penn establishes center to accelerate coronavirus research"
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at University of Pennsylvania, Perelman School of Medicine
159:. As of March 2020, Weiss serves as Co-Director of the
1379:"TWiV 734: Weiss hath no furin like a virus scorned"
1146:"WHO Consensus Document on the Epidemiology of SARS"
120:“Pandemic Perspectives: Interview with Susan Weiss”
108:
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921:Cowley, Timothy J.; Weiss, Susan R. (2010-11-01).
896:"Pandemic Perspectives Interview with Susan Weiss"
838:European Centre for Disease Prevention and Control
175:and graduated in 1971 with her B.A. She moved to
1431:University of California, San Francisco faculty
1243:Proceedings of the National Academy of Sciences
543:on SARS-CoV-2 Omicron variant from January 2022
536:regarding SARS-CoV-2 variants from January 2021
1307:"The origins of SARS-CoV-2: A critical review"
19:For the American poet, author and artist, see
345:Weiss, S. R.; Navas-Martin, S. (2005-12-01).
312:(CDC) to work with the SARS-CoV-2 virus in a
179:for her doctoral research, where she studied
8:
1097:"Why the Coronavirus Has Been So Successful"
1355:"A Coronavirus Chronology with Susan Weiss"
295:In 2020, Weiss was made Co-Director of the
351:Microbiology and Molecular Biology Reviews
310:Centers for Disease Control and Prevention
139:who is a Professor of Microbiology at the
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902:. Science History Institute. 21 May 2020
187:during her postdoctoral research at the
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77:University of California, San Francisco
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337:Nat Commun. 2021 Jan 20;12(1):469.
417:10.1128/jvi.76.21.11065-11078.2002
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275:, which antagonizes OAS-RNase L (
231:and may be transmitted to humans
205:severe acute respiratory syndrome
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209:Middle East respiratory syndrome
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339:doi: 10.1038/s41467-020-20789-7
1150:World Health Organization/IRIS
364:10.1128/mmbr.69.4.635-664.2005
1:
1031:10.1093/gigascience/giaa085
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1436:Brandeis University alumni
1323:10.1016/j.cell.2021.08.017
297:University of Pennsylvania
181:Virulent Newcastle disease
161:University of Pennsylvania
18:
1441:Harvard University alumni
1421:American women scientists
1021:10.1101/2020.03.17.995795
183:. Weiss started studying
124:Science History Institute
113:
100:
61:
1416:American microbiologists
927:Journal of NeuroVirology
290:carcinoembryonic antigen
167:Early life and education
1426:Coronavirus researchers
1264:10.1073/pnas.2022643118
1095:Yong, Ed (2020-03-20).
834:"Q & A on COVID-19"
638:Weiss, Susan R (1976).
324:in both 2020 and 2021.
308:certification from the
16:American microbiologist
712:10.1093/femspd/ftaa006
470:10.1006/viro.2002.1412
217:Human coronavirus 229E
213:Human coronavirus OC43
699:Pathogens and Disease
328:Selected publications
322:This Week in Virology
256:demyelinating disease
248:mouse hepatitis virus
786:www.pennmedicine.org
619:www.pennmedicine.org
1255:2021PNAS..11822643L
1249:(16): e2022643118.
811:Scientific American
410:(21): 11065–11078.
404:Journal of Virology
221:coronavirus disease
199:Research and career
173:Brandeis University
40:Brandeis University
939:10.1007/BF03210848
252:viral encephalitis
244:murine coronavirus
177:Harvard University
45:Harvard University
21:Susan Archer Weiss
1317:(19): 4848–4856.
1196:10.3390/v14020421
876:www.med.upenn.edu
840:. 23 January 2020
595:www.med.upenn.edu
541:Interview/Article
273:phosphodiesterase
237:respiratory tract
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63:Scientific career
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277:Ribonuclease L
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133:Susan R. Weiss
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1383:. Retrieved
1381:. 2021-03-21
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1127:. 2020-03-26
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568:profile for
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539:Susan Weiss
532:Susan Weiss
520:Susan Weiss
510:Susan Weiss
460:
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305:asymptomatic
294:
281:inflammasome
241:
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147:, including
132:
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69:Institutions
62:
1158:10665/70863
1076:EurekAlert!
1008:GigaScience
666:PhillyVoice
572:Susan Weiss
195:in humans.
193:common cold
56:Coronavirus
1400:Categories
1385:2022-03-16
1364:2022-03-16
1189:(2): 421.
1163:2022-03-16
1131:2020-03-31
1106:2020-03-31
1081:2020-03-31
988:2020-03-31
983:Penn Today
881:2020-03-31
844:2020-03-31
816:2020-03-31
791:2020-03-31
767:2020-03-31
762:Penn Today
672:2020-03-31
642:(Thesis).
624:2022-03-16
600:2022-03-16
548:References
301:SARS-CoV-2
269:interferon
264:phenotypic
246:(known as
157:SARS-CoV-2
1273:0027-8424
1205:1999-4915
1058:214725370
947:1538-2443
721:2049-632X
534:Interview
512:Biography
479:0042-6822
426:0022-538X
373:1092-2172
285:cytokines
283:-related
1341:34480864
1291:33811184
1223:35216014
1152:. 2003.
1050:32803225
965:21073281
739:32065221
648:77001271
497:12036329
457:Virology
444:12368349
391:16339739
219:and the
211:(MERS),
207:(SARS),
1359:ASM.org
1332:8373617
1282:8072330
1251:Bibcode
1214:8877841
1183:Viruses
1041:7429184
1016:bioRxiv
956:3153983
730:7108526
564:has an
562:Scholia
522:Profile
488:7133727
382:1306801
1339:
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