39:, however, Rigshospitalet is a flagship in the Danish health care system. From 1990 until his death in 2015, Mortensen was the medical director of the heart transplantation unit at Rigshospitalet. He was a fellow of the European Society of Cardiologists. Mortensen is best known as the chief researcher and the leading author for the
351:
Mortensen's highest concern was the welfare of his heart failure patients and heart transplantation patients. He knew that heart failure is a disabling disease that diminishes the quality of life of the patients. It is a disease with an increasing prevalence. It is a disease that
313:(the "energy starved heart") is a dominant feature of heart failure; his research efforts were focused on finding a well-tolerated agent (Coenzyme Q10) to improve the energy and force of the heart muscle.
269:
631:
Mortensen, S. A. (2003). "Overview on coenzyme Q10 as adjunctive therapy in chronic heart failure. Rationale, design and end-points of "Q-Symbio" - a multinational trial".
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544:
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of the
Coenzyme Q10 when it is dissolved in vegetable oil and administered in capsules manufactured under pharmaceutical quality control
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but also the bio-synthesis of
Coenzyme Q10, thereby reducing the level of Coenzyme Q10 in the blood and in the heart muscle tissue.
327:
responses in the heart. Instead, Coenzyme Q10 naturally enhanced the process of producing energy in the heart muscle cells.
223:
175:
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Mortensen's research established
Coenzyme Q10 adjunctive treatment as a way to improve heart failure outcomes and break the
501:
Mortensen, S. A. & Mortensen, A. L. (2014). "The mitochondria in heart failure: a target for coenzyme Q10 therapy?".
246:
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continues to have a poor prognosis even though advances have been made in various drug and medical device therapies.
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560:"Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with Coenzyme Q10"
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Mortensen was one of the first researchers, along with Dr. Gian-Paulo
Littarru, Dr. Per Langsjoen, and
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study had convinced him of the importance of adequate
Coenzyme Q10 for the heart muscle cells:
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showed significantly improved symptoms and survival for the patients taking the active
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32:
20:
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He summarized the case for
Coenzyme Q10 as an adjunctive treatment for heart failure:
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403:"The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure"
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692:
675:
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Proceedings of the
National Academy of Sciences of the United States of America
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402:
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RCTs: reduced hospitalizations and reduced mortality for heart failure patients
676:"Low Coenzyme Q10 Levels and the Outcome of Statin Treatment in Heart Failure"
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24:
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of chronic heart failure patients with daily
Coenzyme Q10 supplements in the
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19:, M.D., Sc.D. (31 August 1942 – 22 April 2015) was a Danish cardiologist at
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was until
February 2017 the largest hospital in Denmark; only surpassed by
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improved heart function; Coenzyme Q10 as a medication did not block any
111:
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guidelines for the management of heart failure be revised to include
154:
734:
Opie, L.H. (2004). "The metabolic vicious cycle in heart failure".
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As a cardiologist, Mortensen saw multiple treatment options with
558:
Folkers, K., Vadhanavikit, S. & Mortensen, S. A. (1985).
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in the heart muscle tissue and the severity of heart failure.
444:
Overview of
Coenzyme Q10 Treatment in Cardiovascular Disease
717:"Dr. Svend Aage Mortensen, leading Coenzyme Q10 researcher"
110:(100 milligrams three times daily, with meals) or matching
75:
for heart failure patients. The early collaboration with
252:
Interactions: no definite drug interactions reported
79:led to the development of a study protocol for the
214:New guidelines for the management of heart failure
218:Following the publication of the results of the
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392:
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680:Journal of the American College of Cardiology
98:study that investigated the effectiveness of
8:
616:: CS1 maint: multiple names: authors list (
543:: CS1 maint: multiple names: authors list (
316:He liked the safe and positive way in which
245:Safety: no serious side effects recorded in
133:Multiple treatment options with Coenzyme Q10
309:He suspected that energy starvation of the
286:Coenzyme Q10 and the "energy starved heart"
125:treatment together with their conventional
106:form. The patients took 300 milligrams of
67:, who urged more research into the use of
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503:Clinical Pharmacology and Therapeutics
375:Boesgaard, Søren; et al. (2015).
90:study was a multi-center, randomized,
7:
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494:
359:vicious cycle in the heart muscle.
264:of RCTs: improved left ventricular
347:Concern for heart failure patients
290:Mortensen's research prior to the
14:
334:medications inhibit not only the
377:"Mindeord, Svend Aage Mortensen"
222:study, Mortensen urged that the
302:between the concentrations of
224:American College of Cardiology
176:coronary artery bypass surgery
47:on Morbidity and Mortality in
1:
748:10.1016/S0140-6736(04)17412-6
247:randomized controlled trials
401:Mortensen, S.A (Dec 2014).
234:with the natural substance
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693:10.1016/j.jacc.2010.10.051
476:10.1016/j.jchf.2014.12.006
446:. PowerPoint Presentation.
420:10.1016/j.jchf.2014.06.008
228:American Heart Association
674:Mortensen, S. A. (2011).
457:Mortensen, S. A. (2015).
442:Mortensen, S. A. (2015).
298:He knew that there is an
43:study of the "Effect of
645:10.1002/biof.5520180210
715:Morrill, R. L (2015).
193:prophylactic treatment
174:As a pretreatment for
166:ischemic heart disease
151:prophylactic treatment
143:cardiovascular disease
585:10.1073/pnas.82.3.901
515:10.1038/clpt.2014.175
208:chronic heart failure
187:arterial hypertension
117:The results from the
55:Coenzyme Q10 Research
49:Chronic Heart Failure
321:adjunctive treatment
232:adjunctive treatment
204:adjunctive treatment
183:adjunctive treatment
162:adjunctive treatment
100:adjunctive treatment
17:Svend Aage Mortensen
742:(9447): 1733–1734.
576:1985PNAS...82..901F
463:JACC: Heart Failure
407:JACC: Heart Failure
381:Ugeskrift for Læger
300:inverse correlation
277:Formulations: best
63:, to work with Dr.
61:Dr. William V. Judy
330:He was aware that
96:placebo-controlled
73:adjuvant treatment
266:ejection fraction
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639:(1–4): 79–89.
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119:Q-Symbio study
81:Q-Symbio Study
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37:Skejby Sygehus
33:Rigshospitalet
21:Rigshospitalet
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413:(6): 641–49.
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268:and improved
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721:Q10facts.com
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686:(14): 1569.
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612:cite journal
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318:Coenzyme Q10
304:Coenzyme Q10
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139:Coenzyme Q10
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123:Coenzyme Q10
116:
108:Coenzyme Q10
92:double-blind
85:
69:Coenzyme Q10
65:Karl Folkers
58:
45:Coenzyme Q10
16:
15:
788:2015 deaths
783:1942 births
340:cholesterol
77:Dr. Folkers
777:Categories
633:BioFactors
363:References
311:myocardium
255:Efficacy:
104:ubiquinone
25:Copenhagen
357:metabolic
764:45301156
756:15541431
702:21453843
661:21211456
653:14695923
531:35900115
523:25399710
485:25742768
429:25282031
292:Q-Symbio
220:Q-Symbio
112:placebos
88:Q-Symbio
41:Q-Symbio
604:3856239
572:Bibcode
199:therapy
157:therapy
29:Denmark
762:
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736:Lancet
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595:397155
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332:statin
249:(RCT)s
202:As an
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160:As an
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71:as an
760:S2CID
657:S2CID
527:S2CID
272:class
191:As a
149:As a
752:PMID
698:PMID
649:PMID
618:link
600:PMID
545:link
519:PMID
481:PMID
425:PMID
270:NYHA
168:and
86:The
744:doi
740:364
688:doi
641:doi
590:PMC
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