1150:
heterozygote which was unnaturally obese and diabetic. Allele frequency of exon 3 and exon 6 splice at an alliance mutation were analyzed to be similar in
African American and mende tribe and was absent in Caucasians. Exon 6–splice donor being heterozygotes, fat oxidation rates was reduced by 50%, initiating a role for UCP3 in metabolic fuel partitioning. UCP3 (uncoupling protein) deliberates the hypoxia resistance to the renal epithelial cells and its upregulation in renal cell carcinoma. The energy consumption of modulated and the association of -55CT polymorphism of UCP3 with the body weight and in type 2 diabetic patients.
255:
232:
129:
154:
506:
513:
261:
160:
1095:(MACP). UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and transfer of protons from the outer to the inner mitochondrial membrane, reducing the mitochondrial membrane potential in mammalian cells. The exact mechanisms of how UCPs transfer H+/OH− are not known. In addition to UCP1, UCP3 is an important mediator of thermogenesis.
1175:. Uncoupling protein UPC2 and uncoupling protein UPC3 interaction with members of the 14.3.3 family (Benoit pierrat et al., 2000). Uncoupling protein (UCP3) modulating the process of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by declining the mitochondrial ATP fabrication (De Marchi U et al., 2011).
2092:
Clapham JC, Arch JR, Chapman H, Haynes A, Lister C, Moore GB, Piercy V, Carter SA, Lehner I, Smith SA, Beeley LJ, Godden RJ, Herrity N, Skehel M, Changani KK, Hockings PD, Reid DG, Squires SM, Hatcher J, Trail B, Latcham J, Rastan S, Harper AJ, Cadenas S, Buckingham JA, Brand MD, Abuin A (July 2000).
1158:
Since protein UCP3 is affecting the long chain fatty acid metabolism and preventing cytosolic triglyceride storage. Telmisartan being an inhibitor by proven studies on rat skeletal muscle and improving the mutant protein activity and also its involvement in the dominant negative UCP3 mutants(C V Musa
1149:
Mutations in the UCP3 gene are associated with obesity. UCP3 plays an essential role in obesity. A mutation in exon 3 (V102I) was diagnosed in an obese and diabetic. A mutation initializing a stop codon at exon 4 (R143X) and a mutation in the splice donor junction of exon 6 was analyzed in a compound
1112:
UCP3 were confirmed containing four single nucleotide polymorphism rs1800849, rs11235972, rs1726745 and rs3781907. There was high impact score of rs11235972 GG genotype thus showing association of UCP3 gene polymorphism and nonalcoholic fatty liver disease in
Chinese children (Xu YP et al., 2013) The
1103:
Uncoupling proteins are transporters in mitochondrial membrane which deplete the proton gradient. UCP1 is highly expressed in brown adipocytes, UCP2 is variably expressed in many different tissues, and UCP3 is expressed primarily in skeletal muscle. At amino acid level human UCP3 is 71% equivalent to
1113:
research of counterfeits in two independent population there was a similarity between the -55CT mutation of UCP3 and lower BMI. This affiliation was being modulated by the energy intake, hence deriving the undefined effect of diet and partly association of inconsistencies of prior related studies.
2173:
Lanouette CM, Chagnon YC, Rice T, Pérusse L, Muzzin P, Giacobino JP, Gagnon J, Wilmore JH, Leon AS, Skinner JS, Rao DC, Bouchard C (March 2002). "Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study".
1766:
Boss O, Samec S, Paoloni-Giacobino A, Rossier C, Dulloo A, Seydoux J, Muzzin P, Giacobino JP (May 1997). "Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression".
2246:
Hu X, Murphy F, Karwautz A, Li T, Freeman B, Franklin D, Giotakis O, Treasure J, Collier DA (2002). "Analysis of microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa".
1316:
Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (June 1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue".
1159:
et al., 2012). Hence, novel UCP3 gene variants which associated to childhood obesity and even the effect of fatty acid oxidation prevention in triglyceride storage(C V Musa et al., 2012).
1952:
Acín A, Rodriguez M, Rique H, Canet E, Boutin JA, Galizzi JP (May 1999). "Cloning and characterization of the 5' flanking region of the human uncoupling protein 3 (UCP3) gene".
1133:
This gene has tissue-specific transcription initiation with other transcription initiation sites upstream of SM-1 (major skeletal muscle site). Chromosomal order is 5'-UCP3-
268:
167:
1428:"A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population"
786:
2063:
Pierrat B, Ito M, Hinz W, Simonen M, Erdmann D, Chiesi M, Heim J (May 2000). "Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family".
1573:
Pierrat B, Ito M, Hinz W, Simonen M, Erdmann D, Chiesi M, Heim J (May 2000). "Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family".
767:
90:
1071:. Uncoupling proteins transfer anions from the inner mitochondrial membrane to the outer mitochondrial membrane, thereby separating (or uncoupling)
1911:"Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes"
1379:"Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes"
2293:
1263:
1245:
1281:
Boss O, Giacobino JP, Muzzin P (February 1998). "Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13".
1841:"The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts"
254:
1001:
994:
1876:"Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity"
231:
1356:
1232:
1211:
1079:, and dissipating energy stored in the mitochondrial membrane potential as heat. Uncoupling proteins also reduce generation of
153:
128:
1526:"The energy intake modulates the association of the -55CT polymorphism of UCP3 with body weight in type 2 diabetic patients"
1228:
1874:
Urhammer SA, Dalgaard LT, Sørensen TI, Tybjaerg-Hansen A, Echwald SM, Andersen T, Clausen JO, Pedersen O (February 1998).
1469:"UCP-3 uncoupling protein confers hypoxia resistance to renal epithelial cells and is upregulated in renal cell carcinoma"
1806:"Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin"
1614:"The Expression of Uncoupling Protein 3 Coincides With the Fatty Acid Oxidation Type of Metabolism in Adult Murine Heart"
1207:
1068:
70:
1168:
1524:
Lapice E, Monticelli A, Cocozza S, Pinelli M, Giacco A, Rivellese AA, Cocozza S, Riccardi G, Vaccaro O (June 2014).
267:
166:
1067:. The gene is located in chromosome (11q13.4) with an exon count of 7 (HGNC et al., 2016) and is expressed on the
1072:
260:
159:
2205:"Muscle UCP-3 mRNA levels are elevated in weight loss associated with gastrointestinal adenocarcinoma in humans"
831:
78:
1700:
Hilse KE, Kalinovich AV, Rupprecht A, Smorodchenko A, Zeitz U, Staniek K, Erben RG, Pohl EE (January 2016).
1080:
812:
1909:
Argyropoulos G, Brown AM, Willi SM, Zhu J, He Y, Reitman M, Gevao SM, Spruill I, Garvey WT (October 1998).
1377:
Argyropoulos G, Brown AM, Willi SM, Zhu J, He Y, Reitman M, Gevao SM, Spruill I, Garvey WT (October 1998).
2140:"The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents"
1981:
Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R,
1122:
1092:
142:
1426:
Dalgaard LT, Sørensen TI, Drivsholm T, Borch-Johnsen K, Andersen T, Hansen T, Pedersen O (March 2001).
2102:
1480:
1138:
57:
1612:
Hilse KE, Rupprecht A, Egerbacher M, Bardakji S, Zimmermann L, Wulczyn AE, Pohl EE (22 June 2018).
2271:
2126:
2051:
1792:
1555:
1184:
102:
977:
956:
952:
926:
905:
901:
2263:
2234:
2191:
2161:
2118:
2093:"Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean".
2080:
2043:
2008:
1969:
1940:
1897:
1862:
1827:
1784:
1754:
1733:
1688:
1645:
1590:
1547:
1506:
1449:
1408:
1333:
1298:
50:
2255:
2224:
2216:
2183:
2151:
2110:
2072:
2033:
1998:
1961:
1930:
1922:
1887:
1852:
1817:
1776:
1723:
1713:
1678:
1670:
1635:
1625:
1582:
1537:
1496:
1488:
1439:
1398:
1390:
1325:
1290:
505:
347:
278:
222:
177:
512:
322:
98:
1467:
Braun N, Klumpp D, Hennenlotter J, Bedke J, Duranton C, Bleif M, Huber SM (August 2015).
2106:
1484:
2229:
2204:
1728:
1701:
1683:
1658:
1640:
1613:
1501:
1468:
1935:
1910:
1780:
1702:"The expression of UCP3 directly correlates to UCP1 abundance in brown adipose tissue"
1403:
1378:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
621:
605:
600:
595:
590:
585:
569:
564:
559:
554:
2287:
2076:
1982:
1586:
1559:
541:
61:, uncoupling protein 3 (mitochondrial, proton carrier), SLC25A9, uncoupling protein 3
2187:
1796:
82:
2275:
2130:
2055:
1657:
Macher G, Koehler M, Rupprecht A, Kreiter J, Hinterdorfer P, Pohl EE (March 2018).
1076:
340:
119:
1718:
1674:
106:
2138:
Esterbauer H, Oberkofler H, Krempler F, Strosberg AD, Patsch W (November 2000).
1268:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1250:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1659:"Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate"
1091:
Mitochondrial uncoupling protein 3 (UCP3) is a members of the larger family of
423:
239:
136:
86:
1857:
1840:
1822:
1805:
1630:
731:
483:
361:
306:
293:
205:
192:
94:
2267:
2238:
2220:
2195:
2165:
2156:
2139:
2122:
2084:
2047:
2012:
2003:
1986:
1973:
1965:
1758:
1737:
1692:
1649:
1594:
1551:
1510:
1453:
1444:
1427:
1329:
1294:
2259:
1944:
1901:
1892:
1875:
1866:
1831:
1788:
1412:
1337:
1302:
1041:
1542:
1525:
1025:
876:
857:
1357:"Entrez Gene: UCP3 uncoupling protein 3 (mitochondrial, proton carrier)"
1036:
1839:
Solanes G, Vidal-Puig A, Grujic D, Flier JS, Lowell BB (October 1997).
1057:
843:
798:
17:
2038:
2021:
1492:
2114:
1009:
753:
1926:
1394:
2022:"Specific sequence of motifs of mitochondrial uncoupling proteins"
1172:
716:
712:
1134:
1064:
74:
521:
1987:"Energy metabolism in uncoupling protein 3 gene knockout mice"
2203:
Collins P, Bing C, McCulloch P, Williams G (February 2002).
330:
1121:
UCPs contain the three homologous protein domains of
495:
1804:
Gong DW, He Y, Karas M, Reitman M (September 1997).
1432:
The
Journal of Clinical Endocrinology and Metabolism
1954:
1706:
Biochimica et
Biophysica Acta (BBA) - Bioenergetics
1372:
1370:
1368:
1366:
1318:
970:
945:
919:
894:
1745:Muzzin P (April 2002). "The uncoupling proteins".
1663:Biochimica et Biophysica Acta (BBA) - Biomembranes
1224:
1222:
1220:
1203:
1201:
1199:
662:respiratory gaseous exchange by respiratory system
277:
176:
27:Protein-coding gene in the species Homo sapiens
1229:GRCm38: Ensembl release 89: ENSMUSG00000032942
8:
565:oxidative phosphorylation uncoupler activity
1208:GRCh38: Ensembl release 89: ENSG00000175564
727:
537:
396:Skeletal muscle tissue of rectus abdominis
318:
217:
114:
2228:
2155:
2037:
2002:
1934:
1891:
1856:
1821:
1727:
1717:
1682:
1639:
1629:
1541:
1500:
1443:
1402:
1351:
1349:
1347:
1195:
31:
2020:Jezek P, Urbánková E (January 2000).
1915:The Journal of Clinical Investigation
1383:The Journal of Clinical Investigation
687:mitochondrial transmembrane transport
677:cellular response to hormone stimulus
282:
243:
238:
181:
140:
135:
7:
1093:mitochondrial anion carrier proteins
2144:The Journal of Biological Chemistry
1991:The Journal of Biological Chemistry
1845:The Journal of Biological Chemistry
1810:The Journal of Biological Chemistry
450:medial head of gastrocnemius muscle
1054:Mitochondrial uncoupling protein 3
967:
942:
916:
891:
867:
848:
822:
803:
777:
758:
570:transmembrane transporter activity
500:
418:
356:
335:
25:
1060:that in humans is encoded by the
2077:10.1046/j.1432-1327.2000.01285.x
2065:European Journal of Biochemistry
1587:10.1046/j.1432-1327.2000.01285.x
1575:European Journal of Biochemistry
1530:International Journal of Obesity
511:
504:
266:
259:
253:
230:
165:
158:
152:
127:
2188:10.1152/japplphysiol.00726.2001
1141:have been found for this gene.
702:proton transmembrane transport
606:integral component of membrane
522:More reference expression data
484:More reference expression data
1:
2176:Journal of Applied Physiology
1781:10.1016/S0014-5793(97)00384-0
251:
150:
2294:Genes on human chromosome 11
1719:10.1016/j.bbabio.2015.10.011
1675:10.1016/j.bbamem.2017.12.001
1069:inner mitochondrial membrane
667:fatty acid metabolic process
601:mitochondrial inner membrane
642:response to steroid hormone
2310:
652:response to glucocorticoid
438:sternocleidomastoid muscle
2209:British Journal of Cancer
1264:"Mouse PubMed Reference:"
1246:"Human PubMed Reference:"
1073:oxidative phosphorylation
1040:
1035:
1031:
1024:
1008:
1002:Chr 7: 100.12 – 100.14 Mb
989:
974:
949:
938:
923:
898:
887:
874:
870:
855:
851:
842:
829:
825:
810:
806:
797:
784:
780:
765:
761:
752:
737:
730:
726:
710:
540:
536:
519:
503:
494:
481:
454:quadriceps femoris muscle
430:
421:
400:quadriceps femoris muscle
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
1985:, Lowell BB (May 2000).
1858:10.1074/jbc.272.41.25433
1823:10.1074/jbc.272.39.24129
1747:Annales d'Endocrinologie
1631:10.3389/fphys.2018.00747
446:tibialis anterior muscle
1618:Frontiers in Physiology
1167:UCP3 has been shown to
1081:reactive oxygen species
697:mitochondrial transport
591:mitochondrial membranes
404:vastus lateralis muscle
2221:10.1038/sj.bjc.6600074
2157:10.1074/jbc.M005713200
2004:10.1074/jbc.M910179199
1966:10.1006/bbrc.1999.0530
1445:10.1210/jcem.86.3.7301
1330:10.1006/bbrc.1997.6740
1295:10.1006/geno.1997.5135
692:adaptive thermogenesis
627:response to superoxide
442:triceps brachii muscle
392:skeletal muscle tissue
380:triceps brachii muscle
2260:10.1038/sj.mp.4001044
1893:10.1007/s001250050897
995:Chr 11: 74 – 74.01 Mb
143:Chromosome 11 (human)
2248:Molecular Psychiatry
1543:10.1038/ijo.2013.174
657:response to activity
632:response to nutrient
555:transporter activity
372:gastrocnemius muscle
284:7 E2|7 54.36 cM
245:Chromosome 7 (mouse)
2107:2000Natur.406..415C
1485:2015NatSR...513450B
1145:Disease association
672:response to insulin
622:response to hypoxia
1753:(2 Pt 1): 106–10.
1473:Scientific Reports
1185:Uncoupling protein
1099:Protein expression
832:ENSMUSG00000032942
615:Biological process
579:Cellular component
548:Molecular function
384:thoracic diaphragm
2039:10.1080/713803586
1493:10.1038/srep13450
1051:
1050:
1047:
1046:
1020:
1019:
985:
984:
964:
963:
934:
933:
913:
912:
883:
882:
864:
863:
838:
837:
819:
818:
793:
792:
774:
773:
722:
721:
532:
531:
528:
527:
490:
489:
477:
476:
415:
414:
313:
312:
212:
211:
16:(Redirected from
2301:
2279:
2242:
2232:
2199:
2169:
2159:
2134:
2115:10.1038/35019082
2088:
2059:
2041:
2016:
2006:
1997:(21): 16258–66.
1977:
1948:
1938:
1905:
1895:
1870:
1860:
1835:
1825:
1816:(39): 24129–32.
1800:
1762:
1741:
1731:
1721:
1696:
1686:
1653:
1643:
1633:
1599:
1598:
1570:
1564:
1563:
1545:
1521:
1515:
1514:
1504:
1464:
1458:
1457:
1447:
1423:
1417:
1416:
1406:
1374:
1361:
1360:
1353:
1342:
1341:
1313:
1307:
1306:
1278:
1272:
1271:
1260:
1254:
1253:
1242:
1236:
1226:
1215:
1205:
1077:synthesis of ATP
1033:
1032:
1004:
997:
980:
968:
959:
943:
939:RefSeq (protein)
929:
917:
908:
892:
868:
849:
823:
804:
778:
759:
728:
682:response to cold
637:lipid metabolism
538:
524:
515:
508:
501:
486:
470:digastric muscle
458:plantaris muscle
426:
424:Top expressed in
419:
364:
362:Top expressed in
357:
336:
319:
309:
296:
285:
270:
263:
257:
246:
234:
218:
208:
195:
184:
169:
162:
156:
145:
131:
115:
109:
107:UCP3 - orthologs
60:
53:
32:
21:
2309:
2308:
2304:
2303:
2302:
2300:
2299:
2298:
2284:
2283:
2282:
2245:
2202:
2172:
2150:(46): 36394–9.
2137:
2101:(6794): 415–8.
2091:
2062:
2019:
1980:
1951:
1927:10.1172/JCI4115
1908:
1873:
1851:(41): 25433–6.
1838:
1803:
1765:
1744:
1699:
1656:
1611:
1607:
1605:Further reading
1602:
1572:
1571:
1567:
1523:
1522:
1518:
1466:
1465:
1461:
1438:(3): 1398–402.
1425:
1424:
1420:
1395:10.1172/JCI4115
1376:
1375:
1364:
1355:
1354:
1345:
1315:
1314:
1310:
1280:
1279:
1275:
1262:
1261:
1257:
1244:
1243:
1239:
1227:
1218:
1206:
1197:
1193:
1181:
1165:
1156:
1147:
1139:splice variants
1131:
1129:Gene regulation
1119:
1110:
1108:Associated SNPs
1101:
1089:
1042:View/Edit Mouse
1037:View/Edit Human
1000:
993:
990:Location (UCSC)
976:
955:
951:
925:
904:
900:
813:ENSG00000175564
706:
610:
574:
560:protein binding
520:
510:
509:
482:
473:
468:
464:
462:temporal muscle
460:
456:
452:
448:
444:
440:
436:
434:muscle of thigh
422:
411:
406:
402:
398:
394:
390:
386:
382:
378:
376:muscle of thigh
374:
360:
304:
291:
283:
273:
272:
271:
264:
244:
221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
28:
23:
22:
15:
12:
11:
5:
2307:
2305:
2297:
2296:
2286:
2285:
2281:
2280:
2243:
2200:
2170:
2135:
2089:
2060:
2017:
1978:
1949:
1921:(7): 1345–51.
1906:
1871:
1836:
1801:
1763:
1742:
1697:
1669:(3): 664–672.
1654:
1608:
1606:
1603:
1601:
1600:
1565:
1516:
1459:
1418:
1389:(7): 1345–51.
1362:
1343:
1308:
1273:
1255:
1237:
1216:
1194:
1192:
1189:
1188:
1187:
1180:
1177:
1164:
1161:
1155:
1152:
1146:
1143:
1130:
1127:
1118:
1115:
1109:
1106:
1100:
1097:
1088:
1085:
1049:
1048:
1045:
1044:
1039:
1029:
1028:
1022:
1021:
1018:
1017:
1015:
1013:
1006:
1005:
998:
991:
987:
986:
983:
982:
972:
971:
965:
962:
961:
947:
946:
940:
936:
935:
932:
931:
921:
920:
914:
911:
910:
896:
895:
889:
885:
884:
881:
880:
872:
871:
865:
862:
861:
853:
852:
846:
840:
839:
836:
835:
827:
826:
820:
817:
816:
808:
807:
801:
795:
794:
791:
790:
782:
781:
775:
772:
771:
763:
762:
756:
750:
749:
744:
739:
735:
734:
724:
723:
720:
719:
708:
707:
705:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
624:
618:
616:
612:
611:
609:
608:
603:
598:
593:
588:
582:
580:
576:
575:
573:
572:
567:
562:
557:
551:
549:
545:
544:
534:
533:
530:
529:
526:
525:
517:
516:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
428:
427:
416:
413:
412:
410:
409:
408:biceps brachii
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2306:
2295:
2292:
2291:
2289:
2277:
2273:
2269:
2265:
2261:
2257:
2253:
2249:
2244:
2240:
2236:
2231:
2226:
2222:
2218:
2214:
2210:
2206:
2201:
2197:
2193:
2189:
2185:
2182:(3): 1111–8.
2181:
2177:
2171:
2167:
2163:
2158:
2153:
2149:
2145:
2141:
2136:
2132:
2128:
2124:
2120:
2116:
2112:
2108:
2104:
2100:
2096:
2090:
2086:
2082:
2078:
2074:
2071:(9): 2680–7.
2070:
2066:
2061:
2057:
2053:
2049:
2045:
2040:
2035:
2031:
2027:
2023:
2018:
2014:
2010:
2005:
2000:
1996:
1992:
1988:
1984:
1979:
1975:
1971:
1967:
1963:
1960:(2): 278–83.
1959:
1955:
1950:
1946:
1942:
1937:
1932:
1928:
1924:
1920:
1916:
1912:
1907:
1903:
1899:
1894:
1889:
1885:
1881:
1877:
1872:
1868:
1864:
1859:
1854:
1850:
1846:
1842:
1837:
1833:
1829:
1824:
1819:
1815:
1811:
1807:
1802:
1798:
1794:
1790:
1786:
1782:
1778:
1774:
1770:
1764:
1760:
1756:
1752:
1748:
1743:
1739:
1735:
1730:
1725:
1720:
1715:
1711:
1707:
1703:
1698:
1694:
1690:
1685:
1680:
1676:
1672:
1668:
1664:
1660:
1655:
1651:
1647:
1642:
1637:
1632:
1627:
1623:
1619:
1615:
1610:
1609:
1604:
1596:
1592:
1588:
1584:
1581:(9): 2680–7.
1580:
1576:
1569:
1566:
1561:
1557:
1553:
1549:
1544:
1539:
1535:
1531:
1527:
1520:
1517:
1512:
1508:
1503:
1498:
1494:
1490:
1486:
1482:
1478:
1474:
1470:
1463:
1460:
1455:
1451:
1446:
1441:
1437:
1433:
1429:
1422:
1419:
1414:
1410:
1405:
1400:
1396:
1392:
1388:
1384:
1380:
1373:
1371:
1369:
1367:
1363:
1358:
1352:
1350:
1348:
1344:
1339:
1335:
1331:
1327:
1323:
1319:
1312:
1309:
1304:
1300:
1296:
1292:
1288:
1284:
1277:
1274:
1269:
1265:
1259:
1256:
1251:
1247:
1241:
1238:
1234:
1230:
1225:
1223:
1221:
1217:
1213:
1209:
1204:
1202:
1200:
1196:
1190:
1186:
1183:
1182:
1178:
1176:
1174:
1170:
1162:
1160:
1153:
1151:
1144:
1142:
1140:
1136:
1128:
1126:
1124:
1116:
1114:
1107:
1105:
1104:UCP2. UCP3 i
1098:
1096:
1094:
1086:
1084:
1082:
1078:
1074:
1070:
1066:
1063:
1059:
1055:
1043:
1038:
1034:
1030:
1027:
1023:
1016:
1014:
1011:
1007:
1003:
999:
996:
992:
988:
981:
979:
973:
969:
966:
960:
958:
954:
948:
944:
941:
937:
930:
928:
922:
918:
915:
909:
907:
903:
897:
893:
890:
888:RefSeq (mRNA)
886:
879:
878:
873:
869:
866:
860:
859:
854:
850:
847:
845:
841:
834:
833:
828:
824:
821:
815:
814:
809:
805:
802:
800:
796:
789:
788:
783:
779:
776:
770:
769:
764:
760:
757:
755:
751:
748:
745:
743:
740:
736:
733:
729:
725:
718:
714:
709:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
619:
617:
614:
613:
607:
604:
602:
599:
597:
596:mitochondrion
594:
592:
589:
587:
584:
583:
581:
578:
577:
571:
568:
566:
563:
561:
558:
556:
553:
552:
550:
547:
546:
543:
542:Gene ontology
539:
535:
523:
518:
514:
507:
502:
499:
497:
493:
485:
480:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
370:
367:
363:
358:
355:
354:
351:
349:
345:
343:
342:
338:
337:
334:
332:
328:
324:
320:
316:
308:
303:
299:
295:
290:
280:
276:
269:
262:
256:
249:
241:
237:
233:
228:
224:
219:
215:
207:
202:
198:
194:
189:
179:
175:
168:
161:
155:
148:
144:
138:
134:
130:
125:
121:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
30:
19:
2254:(3): 276–7.
2251:
2247:
2215:(3): 372–5.
2212:
2208:
2179:
2175:
2147:
2143:
2098:
2094:
2068:
2064:
2032:(1): 63–70.
2029:
2025:
1994:
1990:
1957:
1953:
1918:
1914:
1886:(2): 241–4.
1883:
1880:Diabetologia
1879:
1848:
1844:
1813:
1809:
1775:(1): 39–42.
1772:
1769:FEBS Letters
1768:
1750:
1746:
1712:(1): 72–78.
1709:
1705:
1666:
1662:
1621:
1617:
1578:
1574:
1568:
1536:(6): 873–7.
1533:
1529:
1519:
1476:
1472:
1462:
1435:
1431:
1421:
1386:
1382:
1324:(1): 79–82.
1321:
1317:
1311:
1289:(3): 425–6.
1286:
1282:
1276:
1267:
1258:
1249:
1240:
1166:
1163:Interactions
1157:
1148:
1132:
1120:
1111:
1102:
1090:
1061:
1053:
1052:
975:
950:
924:
899:
875:
856:
830:
811:
785:
766:
746:
741:
647:human ageing
346:
339:
305:100,135,639
292:100,122,197
66:External IDs
29:
204:74,009,085
191:74,000,277
44:Identifiers
2026:IUBMB Life
1235:, May 2017
1214:, May 2017
1191:References
1154:Inhibitors
466:knee joint
350:(ortholog)
87:HomoloGene
1560:205154594
1479:: 13450.
1137:-3'. Two
1117:Structure
978:NP_033490
957:NP_073714
953:NP_003347
927:NM_009464
906:NM_003356
902:NM_022803
732:Orthologs
95:GeneCards
2288:Category
2268:11920154
2239:11875702
2196:11842047
2166:10958796
2123:10935638
2085:10785390
2048:10772343
2013:10748196
1983:Muoio DM
1974:10329378
1797:33808140
1759:11994670
1738:26518386
1693:29212043
1650:29988383
1595:10785390
1552:24026107
1511:26304588
1454:11238538
1283:Genomics
1231:–
1210:–
1179:See also
1169:interact
1087:Function
1026:Wikidata
711:Sources:
586:membrane
2276:9405576
2230:2375209
2131:4397638
2103:Bibcode
2056:8541209
1945:9769326
1902:9498661
1867:9325252
1832:9305858
1789:9180264
1729:7115856
1684:6118327
1641:6024016
1624:: 747.
1502:4548255
1481:Bibcode
1413:9769326
1338:9196039
1303:9480760
1233:Ensembl
1212:Ensembl
1058:protein
844:UniProt
799:Ensembl
738:Species
717:QuickGO
325:pattern
183:11q13.4
83:1099787
51:Aliases
18:SLC25A9
2274:
2266:
2237:
2227:
2194:
2164:
2129:
2121:
2095:Nature
2083:
2054:
2046:
2011:
1972:
1943:
1936:508981
1933:
1900:
1865:
1830:
1795:
1787:
1757:
1736:
1726:
1691:
1681:
1648:
1638:
1593:
1558:
1550:
1509:
1499:
1452:
1411:
1404:508981
1401:
1336:
1301:
1012:search
1010:PubMed
877:P56501
858:P55916
754:Entrez
496:BioGPS
388:glutes
75:602044
2272:S2CID
2127:S2CID
2052:S2CID
1793:S2CID
1556:S2CID
1173:YWHAQ
1171:with
1123:MACPs
1075:from
1056:is a
787:22229
747:Mouse
742:Human
713:Amigo
348:Mouse
341:Human
288:Start
223:Mouse
187:Start
120:Human
2264:PMID
2235:PMID
2192:PMID
2162:PMID
2119:PMID
2081:PMID
2044:PMID
2009:PMID
1970:PMID
1941:PMID
1898:PMID
1863:PMID
1828:PMID
1785:PMID
1755:PMID
1734:PMID
1710:1857
1689:PMID
1667:1860
1646:PMID
1591:PMID
1548:PMID
1507:PMID
1450:PMID
1409:PMID
1334:PMID
1299:PMID
1135:UCP2
1065:gene
1062:UCP3
768:7352
331:Bgee
279:Band
240:Chr.
178:Band
137:Chr.
99:UCP3
91:2517
71:OMIM
58:UCP3
35:UCP3
2256:doi
2225:PMC
2217:doi
2184:doi
2152:doi
2148:275
2111:doi
2099:406
2073:doi
2069:267
2034:doi
1999:doi
1995:275
1962:doi
1958:258
1931:PMC
1923:doi
1919:102
1888:doi
1853:doi
1849:272
1818:doi
1814:272
1777:doi
1773:408
1724:PMC
1714:doi
1679:PMC
1671:doi
1636:PMC
1626:doi
1583:doi
1579:267
1538:doi
1497:PMC
1489:doi
1440:doi
1399:PMC
1391:doi
1387:102
1326:doi
1322:235
1291:doi
301:End
200:End
103:OMA
79:MGI
2290::
2270:.
2262:.
2250:.
2233:.
2223:.
2213:86
2211:.
2207:.
2190:.
2180:92
2178:.
2160:.
2146:.
2142:.
2125:.
2117:.
2109:.
2097:.
2079:.
2067:.
2050:.
2042:.
2030:49
2028:.
2024:.
2007:.
1993:.
1989:.
1968:.
1956:.
1939:.
1929:.
1917:.
1913:.
1896:.
1884:41
1882:.
1878:.
1861:.
1847:.
1843:.
1826:.
1812:.
1808:.
1791:.
1783:.
1771:.
1751:63
1749:.
1732:.
1722:.
1708:.
1704:.
1687:.
1677:.
1665:.
1661:.
1644:.
1634:.
1620:.
1616:.
1589:.
1577:.
1554:.
1546:.
1534:38
1532:.
1528:.
1505:.
1495:.
1487:.
1475:.
1471:.
1448:.
1436:86
1434:.
1430:.
1407:.
1397:.
1385:.
1381:.
1365:^
1346:^
1332:.
1320:.
1297:.
1287:47
1285:.
1266:.
1248:.
1219:^
1198:^
1125:.
1083:.
715:/
307:bp
294:bp
206:bp
193:bp
101:;
97::
93:;
89::
85:;
81::
77:;
73::
2278:.
2258::
2252:7
2241:.
2219::
2198:.
2186::
2168:.
2154::
2133:.
2113::
2105::
2087:.
2075::
2058:.
2036::
2015:.
2001::
1976:.
1964::
1947:.
1925::
1904:.
1890::
1869:.
1855::
1834:.
1820::
1799:.
1779::
1761:.
1740:.
1716::
1695:.
1673::
1652:.
1628::
1622:9
1597:.
1585::
1562:.
1540::
1513:.
1491::
1483::
1477:5
1456:.
1442::
1415:.
1393::
1359:.
1340:.
1328::
1305:.
1293::
1270:.
1252:.
225:)
122:)
105::
20:)
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