2205:
242:
219:
3018:
1434:
2948:
116:
141:
1356:
1512:
1475:
1522:
2082:
3942:
248:
147:
4500:(androgen-independent), show SLC46A3 expression in DU145 to be about 5 times as high as in LNCaP for percentile ranks and 1.5 times as high for transformed counts, demonstrating an association between SLC46A3 and accelerated cell growth of prostate cancer cells. SLC46A3 possibly contributes to the androgen-independent manner of cancer development.
4186:
SNPs are a very common type of genetic variation and are silent most of the time. However, certain SNPs in the conserved or functionally important regions of the gene may have adverse effects on gene expression and function. Some of the SNPs with potentially damaging effects identified in the coding
2965:
structure (hairpin loop) is often conserved across species due to its role in RNA folding, protecting structural stability, and providing recognition sites for RBPs. The 5' UTR region of SLC46A3 has 7 stem-loop structures identified and 3' UTR region a total of 10. The majority of the binding sites
3084:, which help the protein bind more tightly to the membrane by contributing to protein hydrophobicity and membrane association, is predicted at Cys261 and Cys438. S-palmitoylation can also modulate protein-protein interactions of SLC46A3 by changing the affinity of the protein for
4464:
knockdown in human breast tumor cell line BT-474M1 also results in resistance to T-DM1. Such association between loss of SLC46A3 expression and resistance to ADCs also applies to pyrrolobenzodiazepine warheads, signifying the important role of SLC46A3 in cancer treatment.
3999:(ADCs), maytansine-based noncleavable linker ADC catabolites, such as lysine-MCC-DM1, are particularly responsive to SLC46A3 activity. The protein functions independent of the cell surface target or cell line, thus is most likely to recognize maytansine or a
3951:
The SLC46A3 gene first appeared in fungi approximately 1105 million years ago (MYA). It evolves at a relatively moderate speed. A 1% change in the protein sequence requires about 6.2 million years. The SLC46A3 gene evolves about 4 times faster than
4003:
within the maytansine scaffold. Through transmembrane transport activity, the protein regulates catabolite concentration in the lysosome. In addition, SLC46A3 expression has been identified as a mechanism for resistance to ADCs with noncleavable
1324:(pI) for this protein is 5.56. The protein contains 11 transmembrane domains in addition to domains MFS and MFS_1. MFS and MFS_1 domains largely overlap and contain 42 putative substrate translocation pores that are predicted to bind
1034:
The SLC46A3 gene, also known by its aliases solute carrier family 46 member 3 and FKSG16, is located at 13q12.3 on the reverse strand in humans. The gene spans 18,950 bases from 28,700,064 to 28,719,013 (GRCh38/hg38), flanked by
4012:
warheads. Although subcellular localization predictions have failed to identify the lysosome as a final destination of the protein, the YXXphi motif identified in the protein sequence has shown to direct lysosomal sorting.
8550:"Review for "Therapeutic uncertainties in people with cardiometabolic diseases and severe acute respiratory syndrome coronavirus 2 ( <scp>SARS-CoV</scp> -2 or <scp>COVID</scp> -19)"". 2020-04-07.
3039:
sites (Asn38, Asn46, Asn53), which are all located in the non-cytoplasmic region flanked by the signal peptide and the first transmembrane domain. Ridigity of the N-terminal region close to the membrane is increased by
6520:
Wang GZ, Zhang W, Fang ZT, Zhang W, Yang MJ, Yang GW, et al. (July 2014). "Arsenic trioxide: marked suppression of tumor metastasis potential by inhibiting the transcription factor Twist in vivo and in vitro".
1552:
binding sites are also predicted to reside in the structure, including those for (2S)-2,3-dihydroxypropyl(7Z)-pentadec-7-enoate (78M), cholesterol hemisuccinate (Y01), and octyl glucose neopentyl glycol (37X).
8777:"Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice"
3060:(CKII), suggesting a crosstalking network that regulates protein activity. Other highly conserved phosphorylation sites include Thr166, Ser233, Ser253, and Ser454, which are most likely targeted by kinases
4528:
Western blot analysis supports substantially strong expression of SLC46A3 in papilloma and glioma cells when compared to expression in the liver, one of the organs where the gene is most highly expressed.
1769:(MAX) to affect gene expression in a way that increases cell proliferation and cell metabolism. Its expression is highly amplified in the majority of human cancers, including Burkitt's lymphoma. The
4588:
that is not particularly conserved across coronaviruses, and thus the altering protein sequence leads to significant changes in protein structure, leading to structural and functional variability.
1067:(SNPs) for this gene have been identified. SLC46A3 is expressed at relatively low levels, about 0.5x the average gene. Gene expression is peculiarly high in the liver, small intestine, and kidney.
3124:
1781:(CDP) and nuclear transcription factor Y (NF-Y) have multiple binding sites within the promoter sequence (3 sites for CDP and 2 sites for NF-Y). CDP, also known as Cux1, is a transcriptional
7146:"The Cell: A Molecular Approach. Sixth Edition. By Geoffrey M. Cooper and Robert E. Hausman. Sunderland (Massachusetts): Sinauer Associates. $ 142.95. xxv + 832 p.; ill.; index. 2013".
7586:
Blom N, Sicheritz-Pontén T, Gupta R, Gammeltoft S, Brunak S (June 2004). "Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence".
5931:
Zimmermann L, Stephens A, Nam SZ, Rau D, Kübler J, Lozajic M, et al. (July 2018). "A Completely
Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core".
1215:
3 isoforms have been reported for SLC46A3. Isoform a is MANE select and most abundant. All isoforms contain the MFS and MFS_1 domains as well as the 11 transmembrane regions.
1636:
SLC46A3 carries 4 promoter regions that lead to different transcript variants as identified by ElDorado at
Genomatix. Promoter A supports transcript variant 1 (GXT_2836199).
5389:
255:
154:
7192:
1374:. Two 0 runs that run through several transmembrane domains in addition to a +/* run in between two transmembrane domains are also present. The protein contains a C-(X)
4581:
5381:
7390:
4889:"Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines"
4147:
4104:(AP-MS) identified an interaction between SLC46A3 and LGALS3 with an interaction score of 0.761, classified as high-confidence interacting proteins (HCIPs) by
6584:"Erratum to: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development"
4541:
on obesity identified 10 variants in the flanking 5′UTR region of SLC46A3 that were highly associated with diet fat (% energy) (p = 1.36×10 - 9.57×10). In
1398:
within the endosomal and the secretory pathways of integral membrane proteins by interacting with the mu subunits of the adaptor protein (AP) complex. The
8499:
Graham RL, Sims AC, Baric RS, Denison MR (2006). "The NSP2 Proteins of Mouse
Hepatitis Virus and Sars Coronavirus are Dispensable for Viral Replication".
5639:
Gasteiger E, Hoogland C, Gattiker A, Duvaud S, Wilkins MR, Appel RD, Bairoch A (2005), "Protein
Identification and Analysis Tools on the ExPASy Server",
4449:
of 1.18×10 and 9.01×10. Studies show either lost or significantly reduced SLC46A3 expression (-2.79 fold decrease by microarray with p-value 5.80×10) in
638:
657:
77:
8189:"SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads"
3234:, and fungi. The MFS, MFS_1, and transmembrane domains mostly remain conserved throughout species. A selected list of orthologs obtained through NCBI
2368:
2755:
have binding sites in the conserved regions of the 3' UTR of SLC46A3. The following miRNAs can negatively regulate the expression of the mRNA via
1757:(TFs) bind to the promoter region of SLC46A3 and modulate the transcription of the gene. The table below shows a curated list of predicted TFs.
8007:
Needleman SB, Wunsch CD (March 1970). "A general method applicable to the search for similarities in the amino acid sequence of two proteins".
4017:
4658:
1014:
and therapeutic target for cancer. While protein abundance is relatively low in humans, high expression has been detected particularly in the
974:. It is mainly involved in the transport of small molecules across the membrane through the substrate translocation pores featured in the MFS
8918:
8516:
7425:
7366:
7293:
7167:
7130:
6345:
5991:
5656:
4759:
4676:
1328:
for transmembrane transport. The substrate translocation pores have access to both sides of the membrane in an alternating fashion through a
4572:
Understanding the interaction between SLC46A3 and NSP2 in addition to the functions of each protein is critical to gaining insight into the
2546:
1548:
of 0.853. The structure contains a cluster of 17 α-helices that spans the membrane and random coils that connect those α-helices. Multiple
4513:
2760:
2336:
7551:
Blom N, Gammeltoft S, Brunak S (December 1999). "Sequence and structure-based prediction of eukaryotic protein phosphorylation sites".
241:
888:
881:
6281:"Protein-ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment"
1467:α-helices possess a particular orientation with charged/polar and nonpolar residues on opposite sides of the helix mainly due to the
7672:"Role of advanced glycation end products in mobility and considerations in possible dietary and nutritional intervention strategies"
7048:
3101:
2993:
predicts SLC46A3 to be mainly located at the plasma membrane (78.3%) and ER (17.4%), but also possibly at the mitochondrion (4.3%).
2557:
2271:
1394:
sequence motif, YXXphi, is also found at Tyr246 - Phe249 (YMLF) and Tyr446 - Leu449 (YELL). This Y-based sorting signal directs the
1052:
6404:
5295:
218:
2958:
5138:"SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm"
4441:
screens employing two libraries identified SLC46A3 as the only hit as a mediator of noncleavable maytansine-based ADC-dependent
4645:
4624:
3032:
3006:
2263:
6473:"The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle"
5184:"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics"
4048:, or oxidation of substrates. Some of the most definite and clinically important interactions include the following proteins.
6232:"COFACTOR: improved protein function prediction by combining structure, sequence and protein-protein interaction information"
1177:
1064:
140:
115:
4641:
4437:
The clinical significance of SLC46A3 surrounds the protein's activity as a transporter of maytansine-based ADC catabolites.
4028:
ATP production. The 3' UTR region of SLC46A3 includes a binding site for ENOX1, a protein highly involved in PMET. The C-(X)
8822:"Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease"
7408:
Gupta R, Brunak S (2001). "Prediction of glycosylation across the human proteome and the correlation to protein function".
6007:
Biggin PC, Sansom MS (February 1999). "Interactions of alpha-helices with lipid bilayers: a review of simulation studies".
4951:"Increased expression of SLC46A3 to oppose the progression of hepatocellular carcinoma and its effect on sorafenib therapy"
4538:
3028:
2986:
952:
4620:
8292:"Figure S6: Predicted secondary structure of CoV-RMEN using CFSSP:Chou and Fasman secondary structure prediction server"
4585:
1010:(ADC)-resistant cells and certain cancer cells, current research is focused on the potential of SLC46A3 as a prognostic
57:
3206:
SLC46A3 is a highly conserved protein with orthologs as distant as fungi. Closely related orthologs have been found in
3031:
and is cleaved between Thr20 and Gly21. The resulting mature protein, 441 amino acids of length, is subject to further
2094:
data show SLC46A3 most highly expressed in the liver, small intestine, and kidney and relatively low expression in the
254:
153:
4162:
2204:
1444:
7241:
Käll L, Krogh A, Sonnhammer EL (May 2004). "A combined transmembrane topology and signal peptide prediction method".
3226:
with sequence similarities of 50-70%. More distantly related orthologs have sequence similarities below 50% and are
247:
146:
7394:
4542:
3973:
3969:
2166:
1533:
4724:
1451:
in between. More precisely, the protein is predicted to be composed of 62.9% α-helix, 33.8% random coil, and 3.3%
4469:
4094:
3840:
2174:
1829:
1541:
1305:
8478:
5082:"The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors"
3977:
2979:
2565:
2219:
2038:
1332:. SLC46A3 lacks charged and polar amino acids while containing an excess of nonpolar amino acids, particularly
987:
702:
65:
3017:
3001:, although positivity in the latter two is most likely due to the process of the protein being transported by
1433:
7309:
Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, et al. (May 2013).
7276:
Julenius K, Johansen MB, Zhang Y, Brunak S, Gupta R (2009). "Prediction of
Glycosylation Sites in Proteins".
7191:
Almagro
Armenteros JJ, Tsirigos KD, Sønderby CK, Petersen TN, Winther O, Brunak S, et al. (April 2019).
8923:
4165:
encoded in the orf1ab polyprotein. NSP2 alters the host cell environment rather than contribute directly to
3996:
2012:
1366:
The protein sequence contains mixed, positive, and negative charge clusters, one of each, which are high in
1007:
683:
2947:
5238:
Duff MO, Olson S, Wei X, Garrett SC, Osman A, Bolisetty M, Plocik A, Celniker SE, Graveley BR (May 2015).
4140:
3957:
3706:
3077:
3041:
3036:
2731:
8503:. Advances in Experimental Medicine and Biology. Vol. 581. Boston, MA: Springer US. pp. 67–72.
2778:
8571:
8309:
8043:
4597:
4468:
CDP, one of SLC46A3's transcription factors, works as a tumor suppressor where CDP deficiency activates
4461:
4450:
4097:
4009:
3235:
3119:
SLC46A2: Aliases include thymic stromal cotransporter homolog, TSCOT, and Ly110. SLC46A2 is involved in
2961:
of RNA holds both structural and functional significance. Among various secondary structure motifs, the
2279:
2239:
2215:
1549:
1496:
1383:
1329:
1325:
964:
960:
129:
7955:"Human SLC46A2 Is the Dominant cGAMP Importer in Extracellular cGAMP-Sensing Macrophages and Monocytes"
5020:"Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population"
2613:
critical for mRNA splicing as part of the spliceosome; involved in mRNA nuclear export and translation
5182:
Fagerberg L, Hallström BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, et al. (February 2014).
4016:
SLC46A3 may be involved in plasma membrane electron transport (PMET), a plasma membrane analog of the
1355:
8675:
Wong CC, Martincorena I, Rust AG, Rashid M, Alifrangis C, Alexandrov LB, et al. (January 2014).
8611:
8349:
7734:
6746:
6728:
6646:
6044:"Protter: interactive protein feature visualization and integration with experimental proteomic data"
5885:
5593:
5251:
5031:
4900:
4446:
4113:
4056:
2178:
1754:
1418:
1153:
1085:
1011:
971:
44:
5340:
5080:
Pfefferle S, Schöpf J, Kögl M, Friedel CC, Müller MA, Carbajo-Lozoya J, et al. (October 2011).
4822:
4084:
3904:
3672:
3472:
3438:
2590:
2504:
2259:
1870:
1866:
1492:
1395:
1081:
864:
839:
831:
805:
780:
772:
7451:"The Role of Stress-Induced O-GlcNAc Protein Modification in the Regulation of Membrane Transport"
5489:"PREDICTED: Homo sapiens solute carrier family 46 member 3 (SLC46A3), transcript variant X1, mRNA"
4516:
results on mRNA expression (p < 0.0001). Overexpression of the gene also reduced resistance to
8559:
7611:
7384:
7223:
6546:
6373:
5956:
4550:
4000:
3049:
2994:
2376:
2320:
2316:
2283:
1500:
1468:
89:
6471:
Ellis T, Gambardella L, Horcher M, Tschanz S, Capol J, Bertram P, et al. (September 2001).
3972:, mainly involved in the movement of substrates across the lipid bilayer. The protein works via
2966:
of RBPs and miRNAs given above are located at a stem-loop structure, which is also true for the
1511:
860:
835:
801:
776:
8820:
Chalasani N, Guo X, Loomba R, Goodarzi MO, Haritunians T, Kwon S, et al. (November 2010).
6212:
5735:
Kumar M, Gouw M, Michael S, Sámano-Sánchez H, Pancsa R, Glavina J, et al. (January 2020).
5136:
Hamblett KJ, Jacob AP, Gurgel JL, Tometsko ME, Rock BM, Patel SK, et al. (December 2015).
4997:
4887:
Kanaoka R, Kushiyama A, Seno Y, Nakatsu Y, Matsunaga Y, Fukushima T, et al. (2015-06-03).
4108:. Also known as galectin-3 (Gal3), LGALS3 participates in various cellular functions including
4059:
with a confidence score of 0.632 by the human binary protein interactome (HuRI). Also known as
2876:
2811:
2798:
2416:
associated with polyribosomes; involved in mRNA trafficking; negative regulator of translation
1680:
GXT_2775378, GXT_29165870, GXT_23385588, GXT_2836199, GXT_26222267, GXT_22739111, GXT_23500299
1521:
1474:
8896:
8851:
8798:
8757:
8706:
8657:
8639:
8532:
8512:
8460:
8375:
8249:
8210:
8187:
Kinneer K, Meekin J, Tiberghien AC, Tai YT, Phipps S, Kiefer CM, et al. (December 2018).
8166:
8114:
8065:
8024:
7984:
7899:
7850:
7801:
7760:
7703:
7652:
7603:
7568:
7533:
7482:
7431:
7421:
7372:
7362:
7340:
7289:
7258:
7215:
7173:
7163:
7126:
7095:
7044:
7014:
6947:
6898:
6849:
6795:
6674:
6615:
6538:
6502:
6453:
6361:
6341:
6310:
6261:
6191:
6142:
6075:
6024:
5987:
5948:
5913:
5836:
5766:
5714:
5652:
5621:
5277:
5215:
5159:
5113:
5059:
4972:
4928:
4866:
4755:
4438:
4234:
4166:
4101:
2928:
2915:
2889:
2850:
2785:
2759:. Silencing mechanisms include mRNA cleavage and translation repression based on the level of
2275:
2135:
2081:
1762:
1484:
1391:
1362:
The blue bars enclose the MFS domain and the red brackets the transmembrane regions. i = LVIF.
1321:
1293:
1092:
37:
5693:"Relationship between the occurrence of cysteine in proteins and the complexity of organisms"
3210:
with sequence similarities above 75% while moderately related orthologs come from species of
2837:
2154:
of 75 or above. Conversely, tissues among the most lowly expressed levels of SLC46A3 include
85:
8886:
8876:
8841:
8833:
8788:
8747:
8737:
8696:
8688:
8629:
8619:
8551:
8522:
8504:
8450:
8442:
8365:
8357:
8295:
8241:
8200:
8156:
8148:
8104:
8096:
8055:
8016:
7974:
7966:
7889:
7881:
7840:
7832:
7791:
7750:
7742:
7693:
7683:
7642:
7595:
7560:
7523:
7513:
7472:
7462:
7413:
7330:
7322:
7281:
7250:
7207:
7155:
7118:
7085:
7077:
7036:
7004:
6996:
6937:
6929:
6888:
6880:
6839:
6831:
6785:
6777:
6664:
6654:
6605:
6595:
6530:
6492:
6484:
6443:
6435:
6351:
6333:
6300:
6292:
6251:
6243:
6181:
6173:
6132:
6124:
6065:
6055:
6016:
5979:
5940:
5903:
5893:
5826:
5818:
5756:
5748:
5704:
5644:
5611:
5601:
5411:
5267:
5259:
5205:
5195:
5149:
5103:
5093:
5049:
5039:
4962:
4918:
4908:
4856:
4747:
3781:
3061:
2902:
2863:
2824:
2343:
2223:
2158:
2147:
1379:
1371:
334:
265:
209:
164:
7502:"GPS 5.0: An Update on the Prediction of Kinase-specific Phosphorylation Sites in Proteins"
7117:. Methods in Molecular Biology. Vol. 390. Totowa, NJ: Humana Press. pp. 429–466.
6965:
4746:. Methods in Molecular Biology. Vol. 390. Totowa, NJ: Humana Press. pp. 429–466.
4040:
SLC46A3 has been found to generally interact with proteins involved in membrane transport,
3941:
8775:
Yang R, Wilcox DM, Haasch DL, Jung PM, Nguyen PT, Voorbach MJ, et al. (August 2007).
8584:
8322:
7000:
6385:
5709:
5692:
4068:
4041:
3065:
3057:
3053:
2998:
2967:
2511:
2227:
2162:
2151:
2139:
2099:
1790:
1786:
1487:
of SLC46A3 shows the 11 α-helical transmembrane domains embedded in the membrane with the
1411:
1407:
1152:
Variant 2 encodes isoform b. It lacks a segment in the 3' coding region and the resulting
1133:
1019:
983:
309:
7953:
Cordova, Anthony F.; Ritchie, Christopher; Böhnert, Volker; Li, Lingyin (June 23, 2021).
5018:
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF (2012-12-14).
2319:; binds specifically to expanded dsCUG RNA with unusual size CUG repeats; contributes to
2211:(a)-(c) spinal column of juvenile mouse (P4) and (d) cervical spine of adult mouse (P56).
1425:
with core block lengths of 3 aa (GNYT, VSTF, STFI) are observed throughout the sequence.
8615:
8353:
7738:
6710:
6650:
5889:
5671:
Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2002). "Membrane
Proteins".
5597:
5255:
5035:
4904:
8891:
8864:
8846:
8821:
8752:
8725:
8701:
8676:
8527:
8455:
8430:
8429:
Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, et al. (July 2015).
8370:
8337:
8161:
8136:
7979:
7954:
7894:
7869:
7845:
7820:
7755:
7722:
7698:
7671:
7528:
7501:
7477:
7450:
7335:
7310:
7009:
6984:
6942:
6917:
6893:
6868:
6844:
6819:
6790:
6765:
6610:
6583:
6448:
6423:
6356:
6337:
6305:
6280:
6256:
6231:
6186:
6161:
6137:
6112:
5831:
5806:
5761:
5736:
5272:
5239:
5210:
5183:
5108:
5081:
5054:
5019:
4923:
4888:
4473:
4158:
4154:
4076:
3849:
3806:
3606:
3549:
3515:
3404:
3308:
3081:
2709:
2243:
2103:
1460:
1456:
1414:
1387:
1313:
975:
7090:
7065:
6669:
6634:
6582:
Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, et al. (December 2016).
6497:
6472:
6020:
5983:
5908:
5873:
5553:
5532:
5488:
5471:"Homo sapiens solute carrier family 46 member 3 (SLC46A3), transcript variant 3, mRNA"
5470:
5453:"Homo sapiens solute carrier family 46 member 3 (SLC46A3), transcript variant 2, mRNA"
5452:
5435:"Homo sapiens solute carrier family 46 member 3 (SLC46A3), transcript variant 1, mRNA"
4780:
3857:
3757:
3689:
3655:
3623:
3589:
3557:
3523:
3489:
3455:
3421:
3387:
3355:
3323:
1278:
1262:
1245:
1188:
1168:
1144:
572:
567:
551:
546:
541:
525:
8912:
8634:
8599:
8563:
8555:
8109:
8084:
8020:
7311:"Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology"
7227:
6564:
5616:
5581:
4509:
4132:
4117:
3815:
3715:
2756:
2680:
2491:
2347:
2267:
2170:
2115:
1770:
1422:
1345:
1333:
1317:
979:
956:
512:
7615:
6633:
Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, et al. (April 2004).
6296:
6060:
6043:
5960:
4843:
Li G, Guo J, Shen BQ, Yadav DB, Sliwkowski MX, Crocker LM, et al. (July 2018).
4827:
NCBI (National Center for
Biotechnology Information) CDD (Conserved Domain Database)
1805:) that regulates gene expression, both positively and negatively, by binding to the
1410:(pTyr) pocket that serves as a docking site for the SH2 domain, which is central to
69:
8865:"Identification of candidate genes for human pituitary development by EST analysis"
8662:
NCBI (National Center for
Biotechnology Information) dbSNP Short Genetic Variations
8336:
Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, et al. (April 2020).
6781:
6550:
5511:
5434:
4845:"Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells"
4573:
4558:
4442:
4136:
4005:
3953:
3749:
3291:
3274:
3227:
3184:
3162:
2705:
2553:
2186:
1241:
1129:
1121:
327:
106:
8205:
8188:
7723:"GPS-Lipid: a robust tool for the prediction of multiple lipid modification sites"
7113:
Nakai K, Horton P (2007). "Computational
Prediction of Subcellular Localization".
6439:
6093:
5154:
5137:
4861:
4844:
4742:
Nakai K, Horton P (2007). "Computational Prediction of Subcellular Localization".
4157:
proteins isolated a single-hit interaction between NSP2 and SLC46A3 with a LUMIER
3919:
3887:
3823:
3789:
3723:
8837:
8508:
8300:
8291:
7796:
7779:
6113:"I-TASSER server: new development for protein structure and function predictions"
5822:
5098:
5044:
4967:
4950:
4913:
4032:-C motif in the protein sequence also suggests possible oxidoreductase activity.
93:
8100:
5648:
5240:"Genome-wide identification of zero nucleotide recursive splicing in Drosophila"
4681:
National Center for Biotechnology Information, U.S. National Library of Medicine
4663:
National Center for Biotechnology Information, U.S. National Library of Medicine
4577:
4561:
4457:
4365:
4342:
4296:
4239:
4219:
3540:
3340:
3076:
are predicted at Lys101, Lys239, and Lys374 with possible disrupting effects on
3005:
from the ER to the plasma membrane; myosin transports cargo-containing membrane
2552:
involved in plasma membrane electron transport (PMET) pathways with alternating
2396:
2231:
1464:
1452:
1448:
1370:(Glu). The clusters are located outside the transmembrane regions, and thus are
968:
8604:
Proceedings of the National Academy of Sciences of the United States of America
8446:
8245:
7970:
7417:
6884:
6639:
Proceedings of the National Academy of Sciences of the United States of America
5878:
Proceedings of the National Academy of Sciences of the United States of America
5672:
5586:
Proceedings of the National Academy of Sciences of the United States of America
5415:
4392:
4388:
4319:
4269:
4246:
3983:
A proposed function of SLC46A3 of rising importance is the direct transport of
1455:. The regions of α-helices span the majority of the transmembrane domains. The
410:
8600:"Single-nucleotide polymorphisms can cause different structural folds of mRNA"
8361:
8230:"Plasma membrane electron transport: a new target for cancer drug development"
7885:
7870:"Understanding Protein Palmitoylation: Biological Significance and Enzymology"
7688:
7518:
7285:
7254:
7211:
6600:
6534:
6070:
5944:
5784:
5533:"solute carrier family 46 member 3 isoform b precursor [Homo sapiens]"
5512:"solute carrier family 46 member 3 isoform a precursor [Homo sapiens]"
4781:"solute carrier family 46 member 3 isoform a precursor [Homo sapiens]"
4170:
4090:
4072:
4063:
antigen receptor complex-associated protein alpha chain, CD79A, together with
4025:
4024:
intracellular NADH and contributes to aerobic energy production by supporting
3984:
3740:
3109:
3085:
3048:
at sites Ser227, Thr231, Ser445, and Ser459 are involved in the regulation of
2676:
2143:
2131:
1766:
1488:
1403:
1341:
1340:
is mostly concentrated in the transmembrane regions for interactions with the
1337:
1309:
1157:
226:
123:
73:
8881:
8274:"ENOX1 ecto-NOX disulfide-thiol exchanger 1 [ Homo sapiens (human) ]"
8229:
7836:
7376:
7177:
7122:
4751:
2624:
KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2)
8742:
8624:
8060:
7647:
7630:
7193:"SignalP 5.0 improves signal peptide predictions using deep neural networks"
7040:
6659:
5978:. New Comprehensive Biochemistry. Vol. 31. Elsevier. pp. 425–471.
5854:
5200:
4517:
4488:
Microarray analysis of SLC46A3 in two different prostate cancer cell lines,
4129:
4109:
4045:
3992:
3506:
3481:
3219:
3120:
3069:
2962:
2713:
2448:
2194:
2189:(western blotting) provides evidence for protein abundance in the liver and
2119:
1806:
1782:
1367:
1056:
991:
602:
470:
348:
293:
280:
192:
179:
81:
8900:
8855:
8802:
8793:
8776:
8761:
8710:
8643:
8536:
8464:
8379:
8253:
8214:
8170:
8069:
7988:
7917:
7903:
7854:
7805:
7764:
7707:
7656:
7607:
7599:
7572:
7564:
7537:
7500:
Wang C, Xu H, Lin S, Deng W, Zhou J, Zhang Y, et al. (February 2020).
7486:
7467:
7435:
7344:
7262:
7219:
7099:
7018:
6951:
6902:
6853:
6799:
6678:
6619:
6542:
6506:
6457:
6314:
6265:
6195:
6146:
6079:
6028:
5952:
5859:
ELM (The Eukaryotic Linear Motif resource for Functional Sites in Proteins)
5840:
5789:
ELM (The Eukaryotic Linear Motif resource for Functional Sites in Proteins)
5770:
5718:
5606:
5322:
5281:
5219:
5163:
5117:
5063:
4976:
4932:
4870:
4703:
8273:
8118:
8028:
7935:
7326:
6365:
5917:
5898:
5752:
5625:
3104:: Also known as the proton-coupled folate transporter, SLC46A3 transports
928:
923:
8411:
7081:
6933:
6918:"miRDB: an online database for prediction of functional microRNA targets"
6835:
6247:
6177:
6162:"TM-align: a protein structure alignment algorithm based on the TM-score"
6128:
5580:
Brendel V, Bucher P, Nourbakhsh IR, Blaisdell BE, Karlin S (March 1992).
4493:
4477:
4454:
4125:
4021:
3988:
3681:
3615:
3372:
3231:
3045:
2752:
2586:
2487:
2372:
2235:
2155:
2107:
1545:
1537:
1048:
1003:
912:
747:
728:
8431:"The BioPlex Network: A Systematic Exploration of the Human Interactome"
8393:
7066:"Mfold web server for nucleic acid folding and hybridization prediction"
6820:"RBPmap: a web server for mapping binding sites of RNA-binding proteins"
5263:
4949:
Zhao Q, Zheng B, Meng S, Xu Y, Guo J, Chen LJ, et al. (June 2019).
7821:"CSS-Palm 2.0: an updated software for palmitoylation sites prediction"
6488:
4554:
4150:
4080:
3581:
3447:
3215:
2669:
2561:
2181:
supports expression of the gene in the liver and kidney, as well as in
2111:
2091:
1565:
1349:
999:
944:
714:
669:
7746:
5874:"The hydrophobic moment detects periodicity in protein hydrophobicity"
5582:"Methods and algorithms for statistical analysis of protein sequences"
4838:
4836:
4124:
regulation. The protein is involved in antimicrobial activity against
2226:
of juvenile mouse (P4), SLC46A3 is relatively highly expressed in the
2218:
data show ubiquitous expression of the gene in mouse embryos at stage
8044:"TimeTree: A Resource for Timelines, Timetrees, and Divergence Times"
6692:
6635:"A gene atlas of the mouse and human protein-encoding transcriptomes"
5554:"solute carrier family 46 member 3 isoform X1 [Homo sapiens]"
5358:
4161:
of -0.5. Short for non-structural protein 2, NSP2 is one of the many
4121:
4060:
3647:
3283:
3207:
3105:
3073:
3002:
2698:
2672:(KH RNA binding domain containing, signal transduction associated 1)
2483:
2476:
2198:
2190:
2025:
1774:
1089:
1060:
1044:
1023:
995:
896:
624:
8692:
8152:
7410:
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
7361:. Varki, Ajit (Third ed.). Cold Spring Harbor, New York. 2017.
6985:"The Conservation and Function of RNA Secondary Structure in Plants"
2430:
influences pre-mRNA processing, mRNA metabolism, and mRNA transport
7721:
Xie Y, Zheng Y, Li H, Luo X, He Z, Cao S, et al. (June 2016).
7159:
6422:
Miller DM, Thomas SD, Islam A, Muench D, Sedoris K (October 2012).
2997:
of SLC46A3 shows positivity in the plasma membrane, cytoplasm, and
1176:
Variant 3 also encodes isoform a. Variants 1 and 3 differ in their
8863:
Ma Y, Qi X, Du J, Song S, Feng D, Qi J, et al. (March 2009).
6328:
Latchman DS (2004). "Methods for Studying Transcription Factors".
4546:
4497:
4489:
4064:
4052:
3016:
2990:
2652:
2607:
2594:
2579:
2389:
2309:
2123:
2095:
1944:
1907:
1883:
1853:
1778:
1432:
1399:
1015:
8137:"Lysosomal solute carrier transporters gain momentum in research"
6818:
Paz I, Kosti I, Ares M, Cline M, Mandel-Gutfreund Y (July 2014).
4584:. The NSP2 protein domain resides in a region of the coronavirus
2465:
a tissue-specific splicing regulator; involved in mRNA stability
587:
583:
7280:. Chichester, UK: John Wiley & Sons, Ltd. pp. 163–192.
4801:
4174:
3413:
3223:
3211:
2441:
2410:
2361:
2209:
In Situ Hybridization on Mouse Spinal Column and Cervical Spine.
2182:
2127:
2062:
1957:
1931:
1802:
1798:
1794:
1040:
1036:
948:
61:
8724:
Liu N, Sun Q, Wan L, Wang X, Feng Y, Luo J, Wu H (2020-05-29).
7778:
Aicart-Ramos C, Valero RA, Rodriguez-Crespo I (December 2011).
6569:
NCBI (National Center for Biotechnology Information) BioProject
5493:
NCBI (National Center for Biotechnology Information) Nucleotide
5475:
NCBI (National Center for Biotechnology Information) Nucleotide
5457:
NCBI (National Center for Biotechnology Information) Nucleotide
5439:
NCBI (National Center for Biotechnology Information) Nucleotide
4512:
in 83.2% of human HCC tissues based on western blot scores and
3027:
The SLC46A3 protein contains a signal peptide that facilitates
2346:
by inhibiting the anchorage-independent growth of tumor cells;
1417:. Multiple periodicities typical of an α-helix (periods of 3.6
1080:
SLC46A3 has multiple transcript variants produced by different
6983:
Vandivier LE, Anderson SJ, Foley SW, Gregory BD (April 2016).
5807:"Small peptide recognition sequence for intracellular sorting"
4545:(DIO) mice, SLC46A3 shows decreased gene expression following
2684:
1758:
5974:
Reithmeier RA (1996). "Assembly of proteins into membranes".
4128:
and fungi and has been identified as a negative regulator of
3123:
activity and is a transporter of the immune second messenger
2222:
and the adult mouse brain at postnatal days 56 (P56). In the
5558:
NCBI (National Center for Biotechnology Information) Protein
5537:
NCBI (National Center for Biotechnology Information) Protein
5516:
NCBI (National Center for Biotechnology Information) Protein
4785:
NCBI (National Center for Biotechnology Information) Protein
4520:
treatment and improved overall survival rate (p = 0.00085).
6766:"Roles for RNA-binding proteins in development and disease"
6042:
Omasits U, Ahrens CH, Müller S, Wollscheid B (March 2014).
3113:
2655:(RNA-binding motif, single-stranded-interacting protein 3)
48:, FKSG16, SLC46A3 (gene), solute carrier family 46 member 3
8658:"SNP linked to Gene (geneID:283537) Via Contig Annotation"
7819:
Ren J, Wen L, Gao X, Jin C, Xue Y, Yao X (November 2008).
1421:
in the hydrophobicity) encompass transmembrane domains. 3
8483:
NCBI (National Center for Biotechnology Information) Gene
8398:
NCBI (National Center for Biotechnology Information) Gene
8338:"A reference map of the human binary protein interactome"
8278:
NCBI (National Center for Biotechnology Information) Gene
7940:
NCIB (National Center for Biotechnology Information) Gene
7922:
NCBI (National Center for Biotechnology Information) Gene
4708:
NCBI (National Center for Biotechnology Information) Gene
4472:(PI3K) signaling that leads to tumor growth. The loss of
4460:)-resistant breast cancer cells (KPL-4 TR). In addition,
2627:
influences mRNA splice site selection and exon inclusion
1459:
is also predicted to form an α-helix, most likely in the
951:. Also referred to as FKSG16, the protein belongs to the
7631:"Analysis and prediction of mammalian protein glycation"
2482:
regulates stability of labile mRNA species in activated
317:
8394:"CD79A CD79a molecule [ Homo sapiens (human) ]"
8042:
Kumar S, Stecher G, Suleski M, Hedges SB (July 2017).
5872:
Eisenberg D, Weiss RM, Terwilliger TC (January 1984).
4480:
of CDP are also associated with a variety of cancers.
3995:
structure of maytansine. Among the different types of
2282:. A list of some of the most highly predicted RBPs in
1875:
pregnane X receptor / retinoid X receptor heterodimer
1039:
upstream and CYP51A1P2 downstream. SLC46A3 contains 6
5420:. National Center for Biotechnology Information (US).
1777:(MIZ1), which also binds to the promoter of SLC46A3.
1540:
based on a homologous crystal structure of the human
1006:. Based on the differential expression of SLC46A3 in
482:
8479:"LGALS3 galectin 3 [ Homo sapiens (human) ]"
8135:
Bissa B, Beedle AM, Govindarajan R (November 2016).
7780:"Protein palmitoylation and subcellular trafficking"
5345:
NCBI (National Center for Biotechnology Information)
5327:
NCBI (National Center for Biotechnology Information)
1348:. The transmembrane domains also have a shortage of
1088:. A total of 4 transcript variants are found in the
955:(MFS) and SLC46A family. Most commonly found in the
8726:"CUX1, A Controversial Player in Tumor Development"
8677:"Inactivating CUX1 mutations promote tumorigenesis"
6869:"MicroRNA: Biogenesis, Function and Role in Cancer"
3976:, where the energy for transport is provided by an
2658:(may be) involved in the control of RNA metabolism
2427:HNRNPM (heterogenous nuclear ribonucleoprotein M)
853:
824:
794:
765:
7784:Biochimica et Biophysica Acta (BBA) - Biomembranes
7629:Johansen MB, Kiemer L, Brunak S (September 2006).
5976:Biochemistry of Lipids, Lipoproteins and Membranes
5737:"ELM-the eukaryotic linear motif resource in 2020"
4637:
4635:
4633:
4616:
4614:
4612:
4360:YXXphi motif & STAP1 SH2 domain binding motif
4187:sequence of SLC46A3 are shown in the table below.
2399:; involved in mRNA nuclear export and translation
3052:. In fact, Ser445 and Ser459 are also subject to
1845:myelocytomatosis oncogene (c-Myc proto-oncogene)
264:
163:
6747:"Slc46a3 ISH: Mus musculus, Male, P56, variable"
6523:Journal of Cancer Research and Clinical Oncology
4055:: An interaction with CD79A was identified in a
2086:Gene Expression Array-Based Profile for SLC46A3.
6729:"Slc46a3 ISH: Mus musculus, Male, P4, variable"
4549:(JNK1) depletion, suggesting possible roles in
4424:f*The coordinates/positions are for GRCh38.p7.
2734:levels under stress by protecting target mRNAs
1973:cysteine/serine-rich nuclear protein 1 (AXUD1)
1923:myc-interacting zinc finger protein 1 (ZBTB17)
1761:(c-Myc), the strongest hit at Genomatix with a
16:Protein-coding gene in the species Homo sapiens
8598:Shen LX, Basilion JP, Stanton VP (July 1999).
5643:, Totowa, NJ: Humana Press, pp. 571–607,
4642:GRCm38: Ensembl release 89: ENSMUSG00000029650
2134:data from NCBI GEO present high expression in
1499:of the ER) and the C-terminus extended to the
1406:binding motif at Tyr446 - Ile450 (YELLI) is a
7278:Bioinformatics for Glycobiology and Glycomics
6230:Zhang C, Freddolino PL, Zhang Y (July 2017).
4146:NSP2: A high-throughput Y2H screening of the
2763:between the miRNA and mRNA target sequences.
8:
7670:Chen JH, Lin X, Bu C, Zhang X (2018-10-10).
6405:"SLC46A3 Transcription Factor Binding Sites"
8083:Pao SS, Paulsen IT, Saier MH (March 1998).
7825:Protein Engineering, Design & Selection
6332:. Vol. 270. Elsevier. pp. 23–53.
4621:GRCh38: Ensembl release 89: ENSG00000139508
2582:(CCR4-NOT transcription complex subunit 4)
2447:regulates the stability and translation of
8089:Microbiology and Molecular Biology Reviews
7389:: CS1 maint: location missing publisher (
6867:Macfarlane LA, Murphy PR (November 2010).
5323:"BLAST: Basic Local Alignment Search Tool"
4806:OMIM (Online Mendelian Inheritance in Man)
2395:critical for mRNA splicing as part of the
1773:can repress gene expression by binding to
598:
508:
305:
204:
101:
8890:
8880:
8845:
8792:
8751:
8741:
8700:
8633:
8623:
8526:
8454:
8369:
8299:
8204:
8160:
8108:
8059:
7978:
7893:
7844:
7795:
7754:
7697:
7687:
7646:
7527:
7517:
7506:Genomics, Proteomics & Bioinformatics
7476:
7466:
7455:Oxidative Medicine and Cellular Longevity
7334:
7089:
7008:
6941:
6892:
6843:
6789:
6764:Brinegar AE, Cooper TA (September 2016).
6668:
6658:
6609:
6599:
6496:
6447:
6355:
6304:
6255:
6185:
6136:
6069:
6059:
5907:
5897:
5830:
5760:
5708:
5615:
5605:
5271:
5209:
5199:
5153:
5107:
5097:
5053:
5043:
4966:
4922:
4912:
4860:
4796:
4794:
2610:(serine/arginine-rich splicing factor 3)
2392:(serine/arginine-rich splicing factor 7)
2054:zinc finger and BTB domain containing 24
1888:Ras-responsive element binding protein 1
947:that in humans is encoded by the SLC46A3
8494:
8492:
5417:The Reference Sequence (RefSeq) Database
4189:
3940:
3240:
3129:
2946:
2765:
2525:
2479:(poly(A) binding protein cytoplasmic 4)
2312:(muscleblind like splicing regulator 1)
2288:
2203:
2130:, and stomach demonstrate the opposite.
2080:
1899:transcription factor CP2-like 1 (LBP-9)
1811:
1638:
1555:
1520:
1510:
1473:
1438:Helical Wheel of Transmembrane Domain 3.
1354:
1217:
1097:
8228:Herst PM, Berridge MV (December 2006).
8182:
8180:
8130:
8128:
8002:
8000:
7998:
6813:
6811:
6809:
6279:Yang J, Roy A, Zhang Y (October 2013).
6207:
6205:
5730:
5728:
4608:
4314:conserved substrate translocation pore
3056:, where both sites are associated with
2549:(ecto-NOX disulfide-thiol exchanger 1)
2377:fragile X cognitive disability syndrome
2286:of the 5' and 3' UTRs are shown below.
1202:*Lengths shown do not include introns.
8580:
8569:
8318:
8307:
8141:Clinical Pharmacology and Therapeutics
7382:
6399:
6397:
6395:
6381:
6371:
5800:
5798:
5686:
5684:
5575:
5573:
5571:
5569:
5567:
5376:
5374:
5372:
5317:
5315:
5313:
5311:
5309:
5131:
5129:
5127:
5075:
5073:
5013:
5011:
4992:
4990:
4988:
4986:
4944:
4942:
4882:
4880:
4018:mitochondrial electron transport chain
3112:substrates across cell membranes in a
2339:(zinc finger CCCH-type containing 10)
2177:, all with percentile ranks below 15.
1601:89, 241, 265, 269, 273, 391, 394, 399
18:
7001:10.1146/annurev-arplant-043015-111754
5710:10.1093/oxfordjournals.molbev.a026406
5548:
5546:
5527:
5525:
5506:
5504:
5502:
5429:
5427:
5233:
5231:
5229:
5177:
5175:
5173:
4817:
4815:
2727:RBM42 (RNA binding motif protein 42)
2701:(poly(A) binding protein nuclear 1)
2462:RBM24 (RNA binding motif protein 24)
2242:shows considerable expression in the
1984:CCAAT-displacement protein (CDP/Cux)
1775:myc-interacting zinc finger protein 1
1447:of SLC46A3 is rich in α-helices with
269:
230:
225:
168:
127:
122:
7:
4775:
4773:
4771:
4719:
4717:
4698:
4696:
4694:
4692:
4690:
4418:phosphorylation & O-GlcNAc site
4383:phosphorylation & O-GlcNAc site
2030:transcription factor Kaiso (ZBTB33)
1949:CCAAT/enhancer-binding protein beta
1400:signal-transducing adaptor protein 1
8781:The Journal of Biological Chemistry
7868:Guan X, Fierke CA (December 2011).
5691:Miseta A, Csutora P (August 2000).
5188:Molecular & Cellular Proteomics
3139:Estimated Date of Divergence (MYA)
2712:of poly(A) tails at the 3' ends of
2114:. In fetuses of 10 – 20 weeks, the
1382:(CLLC), which is mostly present in
395:dorsal motor nucleus of vagus nerve
7033:Control of Messenger RNA Stability
6160:Zhang Y, Skolnick J (2005-04-11).
4135:. LGALS3 is highly upregulated in
3022:Conceptual Translation of SLC46A3.
2679:regulation, RNA 3'-end formation,
2675:involved in alternative splicing,
2315:modulates alternative splicing of
2270:expression by getting involved in
1587:112, 116, 197, 198, 201, 204, 208
1360:SLC46A3 Protein Sequence Analysis.
1156:causes isoform b to have a longer
850:
821:
791:
762:
738:
719:
693:
674:
648:
629:
487:
405:
343:
322:
14:
7449:Fisi V, Miseta A, Nagy T (2017).
6565:"Illumina bodyMap2 transcriptome"
5641:The Proteomics Protocols Handbook
4955:Biomedicine & Pharmacotherapy
4729:GeneCards The Human Gene Database
3072:sites at epsilon amino groups of
2730:involved in maintaining cellular
2413:(FMRP translational regulator 1)
2122:report high expression while the
1746:*The coordinates are for GRCh38.
978:. The protein is associated with
941:Solute carrier family 46 member 3
6338:10.1016/b978-012437178-1/50008-4
6330:Eukaryotic Transcription Factors
5811:Current Opinion in Biotechnology
5677:(4th ed.). Garland Science.
3991:to the cytoplasm by binding the
3968:As an MFS protein, SLC46A3 is a
3033:post-translational modifications
2641:stabilizes mRNA by binding AREs
2236:anterior and posterior tubercles
1557:Ligand Binding Sites of SLC46A3
1219:Isoforms of the SLC46A3 Protein
253:
246:
240:
217:
152:
145:
139:
114:
8085:"Major facilitator superfamily"
8048:Molecular Biology and Evolution
7148:The Quarterly Review of Biology
6916:Chen Y, Wang X (January 2020).
5697:Molecular Biology and Evolution
5410:Pruitt K, Brown G, Tatusova T,
3013:Post-Translational Modification
2527:RNA-binding Proteins in 3' UTR
2290:RNA-binding Proteins in 5' UTR
2272:RNA processing and modification
2001:nuclear transcription factor Y
1912:zinc finger protein 34 (KOX32)
1443:Based on results by Ali2D, the
1196:Variant X1 encodes isoform X1.
1099:Transcript Variants of SLC46A3
1065:single nucleotide polymorphisms
6989:Annual Review of Plant Biology
6782:10.1016/j.brainres.2016.02.050
4504:Hepatocellular Carcinoma (HCC)
3029:co-translational translocation
2952:Secondary Structure of 3' UTR.
2803:GCACTTT – GCACTTT – GCACTTTA
2262:(RBPs) that bind to the 5' or
1813:SLC46A3 Transcription Factors
1536:of SLC46A3 was constructed by
1516:Tertiary Structure of SLC46A3.
1095:. Variant 1 is most abundant.
542:integral component of membrane
471:More reference expression data
1:
8206:10.1158/1078-0432.ccr-18-1300
6440:10.1158/1078-0432.CCR-12-0977
6424:"c-Myc and cancer metabolism"
6297:10.1093/bioinformatics/btt447
6111:Yang J, Zhang Y (July 2015).
6061:10.1093/bioinformatics/btt607
6021:10.1016/s0301-4622(98)00233-6
5984:10.1016/s0167-7306(08)60523-2
5674:Molecular Biology of the Cell
5155:10.1158/0008-5472.can-15-1610
4998:"SLC46A3 Polyclonal Antibody"
4862:10.1158/1535-7163.mct-17-0296
4849:Molecular Cancer Therapeutics
4539:genome-wide association study
4169:. The protein interacts with
4057:yeast-two hybrid (Y2H) screen
3238:is shown in the table below.
3080:and function of the protein.
3068:/II, respectively. Conserved
2486:; involved in translation in
1962:Kruppel-like factor 2 (LKLF)
1622:Regulation of Gene Expression
1573:Ligand Binding Site Residues
1526:SLC46A3 Ligand Binding Sites.
1479:Membrane Topology of SLC46A3.
953:major facilitator superfamily
421:epithelium of small intestine
238:
137:
8919:Genes on human chromosome 13
8838:10.1053/j.gastro.2010.07.057
8556:10.1111/dom.14062/v1/review3
8509:10.1007/978-0-387-33012-9_10
8021:10.1016/0022-2836(70)90057-4
8009:Journal of Molecular Biology
7797:10.1016/j.bbamem.2011.07.009
7553:Journal of Molecular Biology
7412:. WORLD SCIENTIFIC: 310–22.
7243:Journal of Molecular Biology
6830:(Web Server issue): W361-7.
5933:Journal of Molecular Biology
5823:10.1016/j.copbio.2010.08.007
5099:10.1371/journal.ppat.1002331
5045:10.1371/journal.pone.0051954
4968:10.1016/j.biopha.2019.108864
4914:10.1371/journal.pone.0127467
4085:signal transduction cascades
3987:-based catabolites from the
2685:human immunodeficiency virus
367:Epithelium of choroid plexus
8101:10.1128/mmbr.62.1.1-34.1998
7115:Protein Targeting Protocols
5341:"Variation Viewer (GRCh38)"
4744:Protein Targeting Protocols
3035:(PTMs). The sequence has 3
2566:disulfide-thiol interchange
2510:stabilizes mRNA by binding
2369:60S large ribosomal subunit
2364:(FMR1 autosomal homolog 2)
2250:Transcript Level Regulation
2067:E2F transcription factor 4
1785:. NF-Y is a heterotrimeric
1404:Src homology 2 (SH2) domain
1292:*Lengths shown are for the
965:multi-pass membrane protein
8940:
8447:10.1016/j.cell.2015.06.043
8301:10.7717/peerj.9572/supp-13
8246:10.2174/156652406779010777
8234:Current Molecular Medicine
7971:10.1021/acscentsci.1c00440
7676:Nutrition & Metabolism
7418:10.1142/9789812799623_0029
7359:Essentials of glycobiology
6885:10.2174/138920210793175895
5805:Pandey KN (October 2010).
4079:(Ig). The BCR responds to
3974:secondary active transport
3956:and 2.5 times slower than
3946:Evolution Rate of SLC46A3.
2995:Immunofluorescent staining
2444:(Y-box binding protein 2)
2167:superior cervical ganglion
1779:CCAAT-displacement protein
379:mucosa of transverse colon
8832:(5): 1567–76, 1576.e1-6.
8362:10.1038/s41586-020-2188-x
7886:10.1007/s11426-011-4428-2
7689:10.1186/s12986-018-0306-7
7519:10.1016/j.gpb.2020.01.001
7286:10.1002/9780470029619.ch9
7255:10.1016/j.jmb.2004.03.016
7212:10.1038/s41587-019-0036-z
6601:10.1186/s13059-016-1123-9
6535:10.1007/s00432-014-1659-6
5945:10.1016/j.jmb.2017.12.007
5649:10.1385/1-59259-890-0:571
4677:"Mouse PubMed Reference:"
4659:"Human PubMed Reference:"
4568:SARS-CoV & SARS-CoV-2
4547:c-Jun N-terminal kinase 1
4470:phosphoinositide 3-kinase
4453:(DM1 payload attached to
4075:associating with surface
3841:Cladophialophora bantiana
3256:Date of Divergence (MYA)
2593:activity; interacts with
2175:colorectal adenocarcinoma
2043:transcription factor Sp4
1834:hypoxia inducible factor
1765:of 0.994, dimerizes with
1615:86, 89, 90, 94, 109, 136
1542:organic anion transporter
1306:integral membrane protein
1063:. So far, more than 4580
927:
922:
918:
911:
895:
889:Chr 5: 147.82 – 147.83 Mb
876:
857:
828:
817:
798:
769:
758:
745:
741:
726:
722:
713:
700:
696:
681:
677:
668:
655:
651:
636:
632:
623:
608:
601:
597:
581:
511:
507:
495:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
8882:10.1186/1471-2164-10-109
8193:Clinical Cancer Research
7123:10.1007/1-59745-466-4_29
6428:Clinical Cancer Research
4752:10.1007/1-59745-466-4_29
4508:SLC46A3 was found to be
3997:antibody-drug conjugates
3978:electrochemical gradient
3373:Ornithorhynchus anatinus
3268:Sequence Similarity (%)
3151:Sequence Similarity (%)
2980:Subcellular Localization
2974:Protein Level Regulation
2017:zinc finger protein 692
1352:(Pro), a helix breaker.
988:hepatocellular carcinoma
8743:10.3389/fonc.2020.00738
8625:10.1073/pnas.96.14.7871
7874:Science China Chemistry
7041:10.1016/c2009-0-03269-3
6711:"SLC46A3 (Mouse Brain)"
6660:10.1073/pnas.0400782101
6477:Genes & Development
6409:Genomatix: MatInspector
5201:10.1074/mcp.m113.035600
5002:ThermoFisher Scientific
4163:non-structural proteins
4069:B-cell antigen receptor
3009:along actin filaments.
1767:myc-associated factor X
1544:MFSD10 (Tetran) with a
1528:A: 78M, B: Y01, C: 37X.
1178:5' untranslated regions
1008:antibody-drug conjugate
882:Chr 13: 28.7 – 28.72 Mb
568:transmembrane transport
8794:10.1074/jbc.m700790200
8579:Cite journal requires
8412:"P11912 (CD79A_HUMAN)"
8317:Cite journal requires
7837:10.1093/protein/gzn039
7600:10.1002/pmic.200300771
7565:10.1006/jmbi.1999.3310
7070:Nucleic Acids Research
6922:Nucleic Acids Research
6824:Nucleic Acids Research
6236:Nucleic Acids Research
6166:Nucleic Acids Research
6117:Nucleic Acids Research
6094:"Q7Z3Q1 (S46A3_HUMAN)"
5741:Nucleic Acids Research
5607:10.1073/pnas.89.6.2002
4580:, namely SARS-CoV and
4524:Papilloma & Glioma
4337:S-palmitoylation site
3958:fibrinogen alpha chain
3948:
3774:Chytriomyces confervae
3707:Schmidtea mediterranea
3673:Nematostella vectensis
3478:Tropical Clawed Frog
3265:Sequence Identity (%)
3148:Sequence Identity (%)
3092:Homology and Evolution
3078:molecular conformation
3064:(PKC), CKII, PKC, and
3024:
2954:
2775:Binding Site Sequence
2687:(HIV) gene expression
2638:HuR (human antigen R)
2246:of adult mouse (P56).
2212:
2088:
1858:GATA-binding factor 1
1529:
1518:
1481:
1440:
1384:metal-binding proteins
1363:
1312:(aa) of length with a
8730:Frontiers in Oncology
8061:10.1093/molbev/msx116
7648:10.1093/glycob/cwl009
7393:) CS1 maint: others (
7327:10.1038/emboj.2013.79
7064:Zuker M (July 2003).
6009:Biophysical Chemistry
5899:10.1073/pnas.81.1.140
4598:Solute carrier family
4428:Clinical Significance
4264:N-glycosylation site
4139:tissue and brains of
4098:affinity purification
4010:pyrrolobenzodiazepine
3944:
3444:Eastern Brown Snake
3262:Sequence Length (aa)
3145:Sequence Length (aa)
3020:
2989:(k-NN) prediction by
2950:
2216:In situ hybridization
2207:
2084:
1936:regulatory factor X5
1818:Transcription Factor
1755:Transcription factors
1750:Transcription Factors
1627:Gene Level Regulation
1524:
1514:
1477:
1436:
1358:
1336:(Phe). The resulting
1330:conformational change
972:transmembrane domains
961:endoplasmic reticulum
547:extracellular exosome
130:Chromosome 13 (human)
7468:10.1155/2017/1308692
7200:Nature Biotechnology
4202:Amino Acid Position
4141:Altzheimer's disease
4036:Interacting Proteins
3970:membrane transporter
3937:Evolutionary History
3741:Trichoplax adhaerens
3678:Starlet Sea Anemone
2842:TCCTTAAA – TCCTTAAA
2683:, and regulation of
2375:; may contribute to
2367:associated with the
2278:, localization, and
2260:RNA-binding proteins
2255:RNA-binding Proteins
2193:, in addition to in
2179:Immunohistochemistry
1493:extracellular region
1491:oriented toward the
1086:alternative splicing
453:olfactory epithelium
232:Chromosome 5 (mouse)
8616:1999PNAS...96.7871S
8354:2020Natur.580..402L
7739:2016NatSR...628249X
6651:2004PNAS..101.6062S
5890:1984PNAS...81..140E
5753:10.1093/nar/gkz1030
5598:1992PNAS...89.2002B
5459:. 13 December 2020.
5441:. 14 December 2020.
5386:Genomatix: ElDorado
5264:10.1038/nature14475
5256:2015Natur.521..376D
5036:2012PLoSO...751954C
4905:2015PLoSO..1027467K
4192:
3905:Aspergillus terreus
3874:Exophiala mesophila
3439:Pseudonaja textilis
3243:
3132:
3116:-dependent manner.
2959:secondary structure
2943:Secondary Structure
2933:TTTCAAA – GTTTCAAA
2855:AATGGGT – AATGGGTA
2816:TTGTTGA – TTGTTGAA
2768:
2591:E3 ubiquitin ligase
2528:
2291:
1814:
1789:of three different
1641:
1558:
1445:secondary structure
1429:Secondary Structure
1220:
1104:Transcript Variant
1100:
1076:Transcript Variants
963:(ER), SLC46A3 is a
371:right lobe of liver
94:SLC46A3 - orthologs
7727:Scientific Reports
7082:10.1093/nar/gkg595
6934:10.1093/nar/gkz757
6836:10.1093/nar/gku406
6489:10.1101/gad.200101
6248:10.1093/nar/gkx366
6213:"I-TASSER results"
6178:10.1093/nar/gki524
6129:10.1093/nar/gkv342
6071:20.500.11850/82692
4551:insulin resistance
4543:diet-induced obese
4208:Amino Acid Change
4190:
4046:catalytic activity
3949:
3640:Drosophila navojoa
3574:Anneissia japonica
3473:Xenopus tropicalis
3247:Genus and Species
3242:SLC46A3 Orthologs
3241:
3130:
3050:signaling pathways
3025:
2987:k-Nearest Neighbor
2955:
2829:ATTTCTA – CATTTCT
2766:
2526:
2507:(human antigen R)
2321:myotonic dystrophy
2289:
2213:
2089:
2077:Expression Pattern
1824:Matrix Similarity
1812:
1759:MYC proto-oncogene
1640:SLC46A3 Promoters
1639:
1556:
1534:tertiary structure
1530:
1519:
1507:Tertiary Structure
1501:cytoplasmic region
1482:
1469:hydrophobic effect
1441:
1364:
1294:precursor proteins
1218:
1132:Variant 1 encodes
1098:
703:ENSMUSG00000029650
573:biological process
561:Biological process
535:Cellular component
526:molecular function
519:Molecular function
449:left lobe of liver
8518:978-0-387-26202-4
8348:(7803): 402–408.
8199:(24): 6570–6582.
7880:(12): 1888–1897.
7747:10.1038/srep28249
7427:978-981-02-4777-5
7368:978-1-62182-132-8
7295:978-0-470-02961-9
7169:978-0-87893-964-0
7132:978-1-58829-702-0
6928:(D1): D127–D131.
6751:Allen Brain Atlas
6733:Allen Brain Atlas
6715:Allen Brain Atlas
6347:978-0-12-437178-1
6242:(W1): W291–W299.
5993:978-0-444-82359-5
5939:(15): 2237–2243.
5785:"TRG_ENDOCYTIC_2"
5747:(D1): D296–D306.
5658:978-1-58829-343-5
4761:978-1-58829-702-0
4422:
4421:
4167:viral replication
4102:mass spectrometry
3934:
3933:
3259:Accession Number
3199:
3198:
3142:Accession Number
3131:SLC46A3 Paralogs
2940:
2939:
2744:
2743:
2704:binds to nascent
2524:
2523:
2284:conserved regions
2150:, and liver with
2136:pancreatic islets
2074:
2073:
1763:matrix similarity
1744:
1743:
1619:
1618:
1485:Membrane topology
1322:isoelectric point
1290:
1289:
1227:Accession Number
1200:
1199:
1107:Accession Number
1055:and SLC46A2, and
938:
937:
934:
933:
907:
906:
872:
871:
847:
846:
813:
812:
788:
787:
754:
753:
735:
734:
709:
708:
690:
689:
664:
663:
645:
644:
593:
592:
503:
502:
499:
498:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
8931:
8904:
8894:
8884:
8859:
8849:
8826:Gastroenterology
8807:
8806:
8796:
8787:(31): 22765–74.
8772:
8766:
8765:
8755:
8745:
8721:
8715:
8714:
8704:
8672:
8666:
8665:
8654:
8648:
8647:
8637:
8627:
8595:
8589:
8588:
8582:
8577:
8575:
8567:
8547:
8541:
8540:
8530:
8496:
8487:
8486:
8475:
8469:
8468:
8458:
8426:
8420:
8419:
8408:
8402:
8401:
8390:
8384:
8383:
8373:
8333:
8327:
8326:
8320:
8315:
8313:
8305:
8303:
8288:
8282:
8281:
8270:
8264:
8263:
8261:
8260:
8225:
8219:
8218:
8208:
8184:
8175:
8174:
8164:
8132:
8123:
8122:
8112:
8080:
8074:
8073:
8063:
8054:(7): 1812–1819.
8039:
8033:
8032:
8004:
7993:
7992:
7982:
7965:(6): 1073–1088.
7950:
7944:
7943:
7932:
7926:
7925:
7914:
7908:
7907:
7897:
7865:
7859:
7858:
7848:
7816:
7810:
7809:
7799:
7775:
7769:
7768:
7758:
7718:
7712:
7711:
7701:
7691:
7667:
7661:
7660:
7650:
7626:
7620:
7619:
7583:
7577:
7576:
7548:
7542:
7541:
7531:
7521:
7497:
7491:
7490:
7480:
7470:
7446:
7440:
7439:
7405:
7399:
7398:
7388:
7380:
7355:
7349:
7348:
7338:
7315:The EMBO Journal
7306:
7300:
7299:
7273:
7267:
7266:
7238:
7232:
7231:
7197:
7188:
7182:
7181:
7154:(4): 399. 2014.
7143:
7137:
7136:
7110:
7104:
7103:
7093:
7061:
7055:
7054:
7029:
7023:
7022:
7012:
6980:
6974:
6973:
6962:
6956:
6955:
6945:
6913:
6907:
6906:
6896:
6873:Current Genomics
6864:
6858:
6857:
6847:
6815:
6804:
6803:
6793:
6761:
6755:
6754:
6743:
6737:
6736:
6725:
6719:
6718:
6707:
6701:
6700:
6689:
6683:
6682:
6672:
6662:
6630:
6624:
6623:
6613:
6603:
6579:
6573:
6572:
6561:
6555:
6554:
6517:
6511:
6510:
6500:
6468:
6462:
6461:
6451:
6419:
6413:
6412:
6401:
6390:
6389:
6383:
6379:
6377:
6369:
6359:
6325:
6319:
6318:
6308:
6276:
6270:
6269:
6259:
6227:
6221:
6220:
6209:
6200:
6199:
6189:
6157:
6151:
6150:
6140:
6108:
6102:
6101:
6090:
6084:
6083:
6073:
6063:
6039:
6033:
6032:
6004:
5998:
5997:
5971:
5965:
5964:
5928:
5922:
5921:
5911:
5901:
5869:
5863:
5862:
5851:
5845:
5844:
5834:
5802:
5793:
5792:
5781:
5775:
5774:
5764:
5732:
5723:
5722:
5712:
5688:
5679:
5678:
5668:
5662:
5661:
5636:
5630:
5629:
5619:
5609:
5577:
5562:
5561:
5550:
5541:
5540:
5529:
5520:
5519:
5508:
5497:
5496:
5485:
5479:
5478:
5467:
5461:
5460:
5449:
5443:
5442:
5431:
5422:
5421:
5407:
5401:
5400:
5398:
5397:
5388:. Archived from
5378:
5367:
5366:
5355:
5349:
5348:
5337:
5331:
5330:
5319:
5304:
5303:
5292:
5286:
5285:
5275:
5235:
5224:
5223:
5213:
5203:
5179:
5168:
5167:
5157:
5133:
5122:
5121:
5111:
5101:
5092:(10): e1002331.
5077:
5068:
5067:
5057:
5047:
5015:
5006:
5005:
4994:
4981:
4980:
4970:
4946:
4937:
4936:
4926:
4916:
4884:
4875:
4874:
4864:
4855:(7): 1441–1453.
4840:
4831:
4830:
4819:
4810:
4809:
4798:
4789:
4788:
4777:
4766:
4765:
4739:
4733:
4732:
4721:
4712:
4711:
4700:
4685:
4684:
4673:
4667:
4666:
4655:
4649:
4639:
4628:
4618:
4496:-dependent) and
4193:
4191:SNPs of SLC46A3
3782:Chytridiomycetes
3253:Taxonomic Group
3244:
3133:
3082:S-palmitoylation
3062:protein kinase C
3058:casein kinase II
2769:
2587:CCR4-NOT complex
2529:
2512:AU rich elements
2344:tumor suppressor
2292:
2159:epithelial cells
2152:percentile ranks
2148:peripheral blood
1815:
1642:
1559:
1314:molecular weight
1221:
1160:than isoform a.
1101:
1047:. There are two
920:
919:
891:
884:
867:
851:
842:
822:
818:RefSeq (protein)
808:
792:
783:
763:
739:
720:
694:
675:
649:
630:
599:
509:
488:
473:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
8939:
8938:
8934:
8933:
8932:
8930:
8929:
8928:
8909:
8908:
8907:
8862:
8819:
8815:
8813:Further reading
8810:
8774:
8773:
8769:
8723:
8722:
8718:
8693:10.1038/ng.2846
8681:Nature Genetics
8674:
8673:
8669:
8656:
8655:
8651:
8597:
8596:
8592:
8578:
8568:
8549:
8548:
8544:
8519:
8501:The Nidoviruses
8498:
8497:
8490:
8477:
8476:
8472:
8428:
8427:
8423:
8410:
8409:
8405:
8392:
8391:
8387:
8335:
8334:
8330:
8316:
8306:
8290:
8289:
8285:
8272:
8271:
8267:
8258:
8256:
8227:
8226:
8222:
8186:
8185:
8178:
8153:10.1002/cpt.450
8134:
8133:
8126:
8082:
8081:
8077:
8041:
8040:
8036:
8006:
8005:
7996:
7952:
7951:
7947:
7934:
7933:
7929:
7916:
7915:
7911:
7867:
7866:
7862:
7818:
7817:
7813:
7790:(12): 2981–94.
7777:
7776:
7772:
7720:
7719:
7715:
7669:
7668:
7664:
7628:
7627:
7623:
7585:
7584:
7580:
7550:
7549:
7545:
7499:
7498:
7494:
7448:
7447:
7443:
7428:
7407:
7406:
7402:
7381:
7369:
7357:
7356:
7352:
7321:(10): 1478–88.
7308:
7307:
7303:
7296:
7275:
7274:
7270:
7240:
7239:
7235:
7195:
7190:
7189:
7185:
7170:
7145:
7144:
7140:
7133:
7112:
7111:
7107:
7076:(13): 3406–15.
7063:
7062:
7058:
7051:
7031:
7030:
7026:
6982:
6981:
6977:
6964:
6963:
6959:
6915:
6914:
6910:
6866:
6865:
6861:
6817:
6816:
6807:
6763:
6762:
6758:
6745:
6744:
6740:
6727:
6726:
6722:
6709:
6708:
6704:
6691:
6690:
6686:
6632:
6631:
6627:
6581:
6580:
6576:
6563:
6562:
6558:
6519:
6518:
6514:
6483:(17): 2307–19.
6470:
6469:
6465:
6434:(20): 5546–53.
6421:
6420:
6416:
6403:
6402:
6393:
6380:
6370:
6348:
6327:
6326:
6322:
6291:(20): 2588–95.
6278:
6277:
6273:
6229:
6228:
6224:
6211:
6210:
6203:
6159:
6158:
6154:
6123:(W1): W174-81.
6110:
6109:
6105:
6092:
6091:
6087:
6041:
6040:
6036:
6006:
6005:
6001:
5994:
5973:
5972:
5968:
5930:
5929:
5925:
5871:
5870:
5866:
5855:"LIG_SH2_STAP1"
5853:
5852:
5848:
5804:
5803:
5796:
5783:
5782:
5778:
5734:
5733:
5726:
5690:
5689:
5682:
5670:
5669:
5665:
5659:
5638:
5637:
5633:
5579:
5578:
5565:
5552:
5551:
5544:
5531:
5530:
5523:
5510:
5509:
5500:
5487:
5486:
5482:
5469:
5468:
5464:
5451:
5450:
5446:
5433:
5432:
5425:
5409:
5408:
5404:
5395:
5393:
5380:
5379:
5370:
5357:
5356:
5352:
5339:
5338:
5334:
5321:
5320:
5307:
5294:
5293:
5289:
5250:(7552): 376–9.
5237:
5236:
5227:
5181:
5180:
5171:
5148:(24): 5329–40.
5142:Cancer Research
5135:
5134:
5125:
5079:
5078:
5071:
5017:
5016:
5009:
4996:
4995:
4984:
4948:
4947:
4940:
4899:(6): e0127467.
4886:
4885:
4878:
4842:
4841:
4834:
4821:
4820:
4813:
4800:
4799:
4792:
4779:
4778:
4769:
4762:
4741:
4740:
4736:
4723:
4722:
4715:
4702:
4701:
4688:
4675:
4674:
4670:
4657:
4656:
4652:
4640:
4631:
4619:
4610:
4606:
4594:
4570:
4535:
4526:
4506:
4486:
4484:Prostate Cancer
4435:
4430:
4290:
4184:
4114:innate immunity
4095:High-throughput
4042:immune response
4038:
4031:
3966:
3939:
3913:Eurotiomycetes
3881:Eurotiomycetes
3541:Rhincodon typus
3314:Rhesus Monkey
3204:
3099:
3094:
3054:phosphorylation
3037:N-glycosylation
3015:
2999:actin filaments
2983:
2976:
2970:at the 3' end.
2945:
2877:hsa-miR-7162-3p
2812:hsa-miR-7159-5p
2799:hsa-miR-106b-5p
2761:complementarity
2749:
2342:functions as a
2257:
2252:
2228:articular facet
2185:tissues, while
2163:caudate nucleus
2140:pituitary gland
2100:skeletal muscle
2079:
1752:
1634:
1629:
1624:
1509:
1453:extended strand
1431:
1412:tyrosine kinase
1408:phosphotyrosine
1388:oxidoreductases
1377:
1372:solvent-exposed
1302:
1213:
1208:
1078:
1073:
1051:for this gene,
1032:
1020:small intestine
984:prostate cancer
957:plasma membrane
943:(SLC46A3) is a
929:View/Edit Mouse
924:View/Edit Human
887:
880:
877:Location (UCSC)
863:
859:
838:
834:
830:
804:
800:
779:
775:
771:
684:ENSG00000139508
577:
556:
530:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
359:mucosa of ileum
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
8937:
8935:
8927:
8926:
8924:Human proteins
8921:
8911:
8910:
8906:
8905:
8860:
8816:
8814:
8811:
8809:
8808:
8767:
8716:
8667:
8649:
8610:(14): 7871–6.
8590:
8581:|journal=
8542:
8517:
8488:
8470:
8441:(2): 425–440.
8421:
8403:
8385:
8328:
8319:|journal=
8283:
8265:
8240:(8): 895–904.
8220:
8176:
8147:(5): 431–436.
8124:
8075:
8034:
7994:
7945:
7927:
7909:
7860:
7831:(11): 639–44.
7811:
7770:
7713:
7662:
7621:
7594:(6): 1633–49.
7578:
7559:(5): 1351–62.
7543:
7492:
7441:
7426:
7400:
7367:
7350:
7301:
7294:
7268:
7249:(5): 1027–36.
7233:
7206:(4): 420–423.
7183:
7168:
7160:10.1086/678645
7138:
7131:
7105:
7056:
7049:
7024:
6975:
6957:
6908:
6859:
6805:
6770:Brain Research
6756:
6738:
6720:
6702:
6684:
6645:(16): 6062–7.
6625:
6588:Genome Biology
6574:
6556:
6529:(7): 1125–36.
6512:
6463:
6414:
6391:
6382:|journal=
6346:
6320:
6285:Bioinformatics
6271:
6222:
6201:
6152:
6103:
6085:
6048:Bioinformatics
6034:
5999:
5992:
5966:
5923:
5864:
5846:
5794:
5776:
5724:
5680:
5663:
5657:
5631:
5563:
5542:
5521:
5498:
5495:. 16 May 2021.
5480:
5477:. 2 July 2020.
5462:
5444:
5423:
5414:(2012-04-06).
5402:
5368:
5350:
5332:
5305:
5287:
5225:
5194:(2): 397–406.
5169:
5123:
5086:PLOS Pathogens
5069:
5030:(12): e51954.
5007:
4982:
4938:
4876:
4832:
4811:
4790:
4767:
4760:
4734:
4725:"SLC46A3 Gene"
4713:
4686:
4668:
4650:
4629:
4607:
4605:
4602:
4601:
4600:
4593:
4590:
4569:
4566:
4534:
4531:
4525:
4522:
4510:down-regulated
4505:
4502:
4485:
4482:
4474:heterozygosity
4434:
4431:
4429:
4426:
4420:
4419:
4416:
4410:
4406:
4402:
4399:
4396:
4385:
4384:
4381:
4378:
4376:
4374:
4371:
4368:
4362:
4361:
4358:
4355:
4353:
4351:
4348:
4345:
4339:
4338:
4335:
4332:
4330:
4328:
4325:
4322:
4316:
4315:
4312:
4309:
4307:
4305:
4302:
4299:
4293:
4292:
4288:
4285:
4282:
4280:
4278:
4275:
4272:
4266:
4265:
4262:
4259:
4257:
4255:
4252:
4249:
4243:
4242:
4237:
4232:
4230:
4228:
4225:
4222:
4216:
4215:
4212:
4209:
4206:
4203:
4200:
4199:mRNA position
4197:
4183:
4180:
4179:
4178:
4144:
4088:
4083:and initiates
4077:immunoglobulin
4037:
4034:
4029:
3965:
3962:
3938:
3935:
3932:
3931:
3928:
3925:
3922:
3917:
3914:
3911:
3908:
3900:
3899:
3896:
3893:
3890:
3885:
3882:
3879:
3876:
3870:
3869:
3866:
3863:
3860:
3858:XP_016623985.1
3855:
3852:
3850:Eurotiomycetes
3847:
3844:
3836:
3835:
3832:
3829:
3826:
3821:
3818:
3813:
3812:White Truffle
3810:
3807:Tuber magnatum
3802:
3801:
3798:
3795:
3792:
3787:
3784:
3779:
3776:
3770:
3769:
3766:
3763:
3760:
3758:XP_002114167.1
3755:
3752:
3747:
3744:
3736:
3735:
3732:
3729:
3726:
3721:
3718:
3713:
3710:
3702:
3701:
3698:
3695:
3692:
3690:XP_001640625.1
3687:
3684:
3679:
3676:
3668:
3667:
3664:
3661:
3658:
3656:XP_030245348.1
3653:
3650:
3645:
3642:
3636:
3635:
3632:
3629:
3626:
3624:XP_033735180.1
3621:
3618:
3613:
3612:Great Scallop
3610:
3607:Pecten maximus
3602:
3601:
3598:
3595:
3592:
3590:XP_033118008.1
3587:
3584:
3579:
3576:
3570:
3569:
3566:
3563:
3560:
3558:XP_020383213.1
3555:
3552:
3550:Chondrichthyes
3547:
3544:
3536:
3535:
3532:
3529:
3526:
3524:XP_021329877.1
3521:
3518:
3516:Actinopterygii
3513:
3510:
3502:
3501:
3498:
3495:
3492:
3490:XP_002934077.1
3487:
3484:
3479:
3476:
3468:
3467:
3464:
3461:
3458:
3456:XP_026564717.1
3453:
3450:
3445:
3442:
3434:
3433:
3430:
3427:
3424:
3422:NP_001025999.1
3419:
3416:
3411:
3408:
3400:
3399:
3396:
3393:
3390:
3388:XP_028904425.1
3385:
3382:
3379:
3376:
3368:
3367:
3364:
3361:
3358:
3356:NP_001343931.1
3353:
3350:
3347:
3344:
3336:
3335:
3332:
3329:
3326:
3324:XP_014976295.2
3321:
3318:
3315:
3312:
3309:Macaca mulatta
3304:
3303:
3300:
3297:
3294:
3289:
3286:
3281:
3278:
3270:
3269:
3266:
3263:
3260:
3257:
3254:
3251:
3248:
3203:
3200:
3197:
3196:
3193:
3190:
3187:
3182:
3179:
3175:
3174:
3171:
3168:
3165:
3160:
3157:
3153:
3152:
3149:
3146:
3143:
3140:
3137:
3098:
3095:
3093:
3090:
3014:
3011:
2982:
2977:
2975:
2972:
2968:poly(A) signal
2944:
2941:
2938:
2937:
2934:
2931:
2929:hsa-miR-510-3p
2925:
2924:
2921:
2918:
2916:hsa-miR-597-3p
2912:
2911:
2908:
2905:
2899:
2898:
2895:
2892:
2890:hsa-miR-137-3p
2886:
2885:
2882:
2879:
2873:
2872:
2869:
2866:
2860:
2859:
2856:
2853:
2851:hsa-miR-660-5p
2847:
2846:
2843:
2840:
2834:
2833:
2830:
2827:
2821:
2820:
2817:
2814:
2808:
2807:
2804:
2801:
2795:
2794:
2791:
2788:
2786:hsa-miR-494-3p
2782:
2781:
2776:
2773:
2748:
2745:
2742:
2741:
2738:
2735:
2728:
2724:
2723:
2720:
2717:
2710:polymerization
2702:
2695:
2694:
2691:
2688:
2673:
2666:
2665:
2662:
2659:
2656:
2649:
2648:
2645:
2642:
2639:
2635:
2634:
2631:
2628:
2625:
2621:
2620:
2617:
2614:
2611:
2604:
2603:
2600:
2597:
2583:
2576:
2575:
2572:
2569:
2550:
2543:
2542:
2539:
2536:
2533:
2522:
2521:
2518:
2515:
2508:
2501:
2500:
2497:
2494:
2492:megakaryocytes
2480:
2473:
2472:
2469:
2466:
2463:
2459:
2458:
2455:
2452:
2445:
2438:
2437:
2434:
2431:
2428:
2424:
2423:
2420:
2417:
2414:
2407:
2406:
2403:
2400:
2393:
2386:
2385:
2382:
2379:
2365:
2358:
2357:
2354:
2351:
2340:
2333:
2332:
2326:
2323:
2313:
2306:
2305:
2302:
2299:
2296:
2276:nuclear export
2256:
2253:
2251:
2248:
2244:cervical spine
2187:immunoblotting
2104:salivary gland
2078:
2075:
2072:
2071:
2068:
2065:
2059:
2058:
2055:
2052:
2048:
2047:
2044:
2041:
2035:
2034:
2031:
2028:
2022:
2021:
2018:
2015:
2009:
2008:
2002:
1999:
1995:
1994:
1985:
1982:
1978:
1977:
1974:
1971:
1967:
1966:
1963:
1960:
1954:
1953:
1950:
1947:
1941:
1940:
1937:
1934:
1928:
1927:
1924:
1921:
1917:
1916:
1913:
1910:
1904:
1903:
1900:
1897:
1893:
1892:
1889:
1886:
1880:
1879:
1876:
1873:
1863:
1862:
1859:
1856:
1850:
1849:
1846:
1843:
1839:
1838:
1835:
1832:
1826:
1825:
1822:
1819:
1751:
1748:
1742:
1741:
1738:
1735:
1732:
1729:
1726:
1722:
1721:
1718:
1715:
1712:
1709:
1706:
1702:
1701:
1698:
1695:
1692:
1689:
1686:
1682:
1681:
1678:
1675:
1672:
1669:
1666:
1662:
1661:
1658:
1655:
1652:
1649:
1646:
1633:
1630:
1628:
1625:
1623:
1620:
1617:
1616:
1613:
1610:
1607:
1603:
1602:
1599:
1596:
1593:
1589:
1588:
1585:
1582:
1579:
1575:
1574:
1571:
1568:
1563:
1532:Model for the
1508:
1505:
1457:signal peptide
1430:
1427:
1423:tandem repeats
1392:sorting-signal
1375:
1344:chains in the
1338:hydrophobicity
1304:SLC46A3 is an
1301:
1298:
1288:
1287:
1284:
1281:
1279:XP_005266418.1
1276:
1272:
1271:
1268:
1265:
1263:NP_001129391.1
1260:
1256:
1255:
1252:
1249:
1246:NP_001334889.1
1239:
1235:
1234:
1231:
1228:
1225:
1212:
1209:
1207:
1204:
1198:
1197:
1194:
1191:
1189:XM_005266361.2
1186:
1182:
1181:
1174:
1171:
1169:NM_001347960.1
1166:
1162:
1161:
1150:
1147:
1145:NM_001135919.2
1142:
1138:
1137:
1127:
1124:
1119:
1115:
1114:
1111:
1108:
1105:
1077:
1074:
1072:
1069:
1059:as distant as
1031:
1028:
936:
935:
932:
931:
926:
916:
915:
909:
908:
905:
904:
902:
900:
893:
892:
885:
878:
874:
873:
870:
869:
855:
854:
848:
845:
844:
826:
825:
819:
815:
814:
811:
810:
796:
795:
789:
786:
785:
767:
766:
760:
756:
755:
752:
751:
743:
742:
736:
733:
732:
724:
723:
717:
711:
710:
707:
706:
698:
697:
691:
688:
687:
679:
678:
672:
666:
665:
662:
661:
653:
652:
646:
643:
642:
634:
633:
627:
621:
620:
615:
610:
606:
605:
595:
594:
591:
590:
579:
578:
576:
575:
570:
564:
562:
558:
557:
555:
554:
549:
544:
538:
536:
532:
531:
529:
528:
522:
520:
516:
515:
505:
504:
501:
500:
497:
496:
493:
492:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
437:salivary gland
434:
430:
426:
425:lacrimal gland
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
363:jejunal mucosa
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
8936:
8925:
8922:
8920:
8917:
8916:
8914:
8902:
8898:
8893:
8888:
8883:
8878:
8874:
8870:
8866:
8861:
8857:
8853:
8848:
8843:
8839:
8835:
8831:
8827:
8823:
8818:
8817:
8812:
8804:
8800:
8795:
8790:
8786:
8782:
8778:
8771:
8768:
8763:
8759:
8754:
8749:
8744:
8739:
8735:
8731:
8727:
8720:
8717:
8712:
8708:
8703:
8698:
8694:
8690:
8686:
8682:
8678:
8671:
8668:
8663:
8659:
8653:
8650:
8645:
8641:
8636:
8631:
8626:
8621:
8617:
8613:
8609:
8605:
8601:
8594:
8591:
8586:
8573:
8565:
8561:
8557:
8553:
8546:
8543:
8538:
8534:
8529:
8524:
8520:
8514:
8510:
8506:
8502:
8495:
8493:
8489:
8484:
8480:
8474:
8471:
8466:
8462:
8457:
8452:
8448:
8444:
8440:
8436:
8432:
8425:
8422:
8417:
8413:
8407:
8404:
8399:
8395:
8389:
8386:
8381:
8377:
8372:
8367:
8363:
8359:
8355:
8351:
8347:
8343:
8339:
8332:
8329:
8324:
8311:
8302:
8297:
8293:
8287:
8284:
8279:
8275:
8269:
8266:
8255:
8251:
8247:
8243:
8239:
8235:
8231:
8224:
8221:
8216:
8212:
8207:
8202:
8198:
8194:
8190:
8183:
8181:
8177:
8172:
8168:
8163:
8158:
8154:
8150:
8146:
8142:
8138:
8131:
8129:
8125:
8120:
8116:
8111:
8106:
8102:
8098:
8094:
8090:
8086:
8079:
8076:
8071:
8067:
8062:
8057:
8053:
8049:
8045:
8038:
8035:
8030:
8026:
8022:
8018:
8015:(3): 443–53.
8014:
8010:
8003:
8001:
7999:
7995:
7990:
7986:
7981:
7976:
7972:
7968:
7964:
7960:
7956:
7949:
7946:
7941:
7937:
7931:
7928:
7923:
7919:
7913:
7910:
7905:
7901:
7896:
7891:
7887:
7883:
7879:
7875:
7871:
7864:
7861:
7856:
7852:
7847:
7842:
7838:
7834:
7830:
7826:
7822:
7815:
7812:
7807:
7803:
7798:
7793:
7789:
7785:
7781:
7774:
7771:
7766:
7762:
7757:
7752:
7748:
7744:
7740:
7736:
7732:
7728:
7724:
7717:
7714:
7709:
7705:
7700:
7695:
7690:
7685:
7681:
7677:
7673:
7666:
7663:
7658:
7654:
7649:
7644:
7641:(9): 844–53.
7640:
7636:
7632:
7625:
7622:
7617:
7613:
7609:
7605:
7601:
7597:
7593:
7589:
7582:
7579:
7574:
7570:
7566:
7562:
7558:
7554:
7547:
7544:
7539:
7535:
7530:
7525:
7520:
7515:
7511:
7507:
7503:
7496:
7493:
7488:
7484:
7479:
7474:
7469:
7464:
7460:
7456:
7452:
7445:
7442:
7437:
7433:
7429:
7423:
7419:
7415:
7411:
7404:
7401:
7396:
7392:
7386:
7378:
7374:
7370:
7364:
7360:
7354:
7351:
7346:
7342:
7337:
7332:
7328:
7324:
7320:
7316:
7312:
7305:
7302:
7297:
7291:
7287:
7283:
7279:
7272:
7269:
7264:
7260:
7256:
7252:
7248:
7244:
7237:
7234:
7229:
7225:
7221:
7217:
7213:
7209:
7205:
7201:
7194:
7187:
7184:
7179:
7175:
7171:
7165:
7161:
7157:
7153:
7149:
7142:
7139:
7134:
7128:
7124:
7120:
7116:
7109:
7106:
7101:
7097:
7092:
7087:
7083:
7079:
7075:
7071:
7067:
7060:
7057:
7052:
7050:9780120847822
7046:
7042:
7038:
7034:
7028:
7025:
7020:
7016:
7011:
7006:
7002:
6998:
6995:(1): 463–88.
6994:
6990:
6986:
6979:
6976:
6971:
6967:
6961:
6958:
6953:
6949:
6944:
6939:
6935:
6931:
6927:
6923:
6919:
6912:
6909:
6904:
6900:
6895:
6890:
6886:
6882:
6879:(7): 537–61.
6878:
6874:
6870:
6863:
6860:
6855:
6851:
6846:
6841:
6837:
6833:
6829:
6825:
6821:
6814:
6812:
6810:
6806:
6801:
6797:
6792:
6787:
6783:
6779:
6775:
6771:
6767:
6760:
6757:
6752:
6748:
6742:
6739:
6734:
6730:
6724:
6721:
6716:
6712:
6706:
6703:
6698:
6694:
6688:
6685:
6680:
6676:
6671:
6666:
6661:
6656:
6652:
6648:
6644:
6640:
6636:
6629:
6626:
6621:
6617:
6612:
6607:
6602:
6597:
6593:
6589:
6585:
6578:
6575:
6570:
6566:
6560:
6557:
6552:
6548:
6544:
6540:
6536:
6532:
6528:
6524:
6516:
6513:
6508:
6504:
6499:
6494:
6490:
6486:
6482:
6478:
6474:
6467:
6464:
6459:
6455:
6450:
6445:
6441:
6437:
6433:
6429:
6425:
6418:
6415:
6410:
6406:
6400:
6398:
6396:
6392:
6387:
6375:
6367:
6363:
6358:
6353:
6349:
6343:
6339:
6335:
6331:
6324:
6321:
6316:
6312:
6307:
6302:
6298:
6294:
6290:
6286:
6282:
6275:
6272:
6267:
6263:
6258:
6253:
6249:
6245:
6241:
6237:
6233:
6226:
6223:
6218:
6214:
6208:
6206:
6202:
6197:
6193:
6188:
6183:
6179:
6175:
6172:(7): 2302–9.
6171:
6167:
6163:
6156:
6153:
6148:
6144:
6139:
6134:
6130:
6126:
6122:
6118:
6114:
6107:
6104:
6099:
6095:
6089:
6086:
6081:
6077:
6072:
6067:
6062:
6057:
6053:
6049:
6045:
6038:
6035:
6030:
6026:
6022:
6018:
6015:(3): 161–83.
6014:
6010:
6003:
6000:
5995:
5989:
5985:
5981:
5977:
5970:
5967:
5962:
5958:
5954:
5950:
5946:
5942:
5938:
5934:
5927:
5924:
5919:
5915:
5910:
5905:
5900:
5895:
5891:
5887:
5883:
5879:
5875:
5868:
5865:
5860:
5856:
5850:
5847:
5842:
5838:
5833:
5828:
5824:
5820:
5817:(5): 611–20.
5816:
5812:
5808:
5801:
5799:
5795:
5790:
5786:
5780:
5777:
5772:
5768:
5763:
5758:
5754:
5750:
5746:
5742:
5738:
5731:
5729:
5725:
5720:
5716:
5711:
5706:
5703:(8): 1232–9.
5702:
5698:
5694:
5687:
5685:
5681:
5676:
5675:
5667:
5664:
5660:
5654:
5650:
5646:
5642:
5635:
5632:
5627:
5623:
5618:
5613:
5608:
5603:
5599:
5595:
5592:(6): 2002–6.
5591:
5587:
5583:
5576:
5574:
5572:
5570:
5568:
5564:
5559:
5555:
5549:
5547:
5543:
5538:
5534:
5528:
5526:
5522:
5517:
5513:
5507:
5505:
5503:
5499:
5494:
5490:
5484:
5481:
5476:
5472:
5466:
5463:
5458:
5454:
5448:
5445:
5440:
5436:
5430:
5428:
5424:
5419:
5418:
5413:
5406:
5403:
5392:on 2021-08-26
5391:
5387:
5383:
5377:
5375:
5373:
5369:
5364:
5360:
5354:
5351:
5346:
5342:
5336:
5333:
5328:
5324:
5318:
5316:
5314:
5312:
5310:
5306:
5301:
5297:
5291:
5288:
5283:
5279:
5274:
5269:
5265:
5261:
5257:
5253:
5249:
5245:
5241:
5234:
5232:
5230:
5226:
5221:
5217:
5212:
5207:
5202:
5197:
5193:
5189:
5185:
5178:
5176:
5174:
5170:
5165:
5161:
5156:
5151:
5147:
5143:
5139:
5132:
5130:
5128:
5124:
5119:
5115:
5110:
5105:
5100:
5095:
5091:
5087:
5083:
5076:
5074:
5070:
5065:
5061:
5056:
5051:
5046:
5041:
5037:
5033:
5029:
5025:
5021:
5014:
5012:
5008:
5003:
4999:
4993:
4991:
4989:
4987:
4983:
4978:
4974:
4969:
4964:
4960:
4956:
4952:
4945:
4943:
4939:
4934:
4930:
4925:
4920:
4915:
4910:
4906:
4902:
4898:
4894:
4890:
4883:
4881:
4877:
4872:
4868:
4863:
4858:
4854:
4850:
4846:
4839:
4837:
4833:
4828:
4824:
4818:
4816:
4812:
4807:
4803:
4797:
4795:
4791:
4786:
4782:
4776:
4774:
4772:
4768:
4763:
4757:
4753:
4749:
4745:
4738:
4735:
4730:
4726:
4720:
4718:
4714:
4709:
4705:
4699:
4697:
4695:
4693:
4691:
4687:
4682:
4678:
4672:
4669:
4664:
4660:
4654:
4651:
4647:
4643:
4638:
4636:
4634:
4630:
4626:
4622:
4617:
4615:
4613:
4609:
4603:
4599:
4596:
4595:
4591:
4589:
4587:
4583:
4579:
4578:coronaviruses
4575:
4567:
4565:
4563:
4560:
4556:
4552:
4548:
4544:
4540:
4532:
4530:
4523:
4521:
4519:
4515:
4511:
4503:
4501:
4499:
4495:
4491:
4483:
4481:
4479:
4475:
4471:
4466:
4463:
4459:
4456:
4452:
4448:
4444:
4440:
4432:
4427:
4425:
4417:
4415:
4411:
4409:
4407:
4405:
4403:
4400:
4397:
4395:
4394:
4390:
4387:
4386:
4382:
4379:
4377:
4375:
4372:
4369:
4367:
4364:
4363:
4359:
4356:
4354:
4352:
4349:
4346:
4344:
4341:
4340:
4336:
4333:
4331:
4329:
4326:
4323:
4321:
4318:
4317:
4313:
4310:
4308:
4306:
4303:
4300:
4298:
4295:
4294:
4286:
4283:
4281:
4279:
4276:
4273:
4271:
4268:
4267:
4263:
4260:
4258:
4256:
4253:
4250:
4248:
4245:
4244:
4241:
4238:
4236:
4233:
4231:
4229:
4226:
4223:
4221:
4218:
4217:
4213:
4210:
4207:
4204:
4201:
4198:
4195:
4194:
4188:
4181:
4176:
4173:1 (PHB1) and
4172:
4168:
4164:
4160:
4156:
4152:
4149:
4145:
4142:
4138:
4134:
4133:degranulation
4131:
4127:
4123:
4119:
4118:cell adhesion
4115:
4111:
4107:
4106:CompPASS-Plus
4103:
4099:
4096:
4092:
4089:
4086:
4082:
4078:
4074:
4070:
4066:
4062:
4058:
4054:
4051:
4050:
4049:
4047:
4043:
4035:
4033:
4027:
4023:
4019:
4014:
4011:
4007:
4002:
3998:
3994:
3990:
3986:
3981:
3979:
3975:
3971:
3963:
3961:
3959:
3955:
3947:
3943:
3936:
3929:
3926:
3923:
3921:
3918:
3915:
3912:
3909:
3907:
3906:
3902:
3901:
3897:
3894:
3891:
3889:
3886:
3883:
3880:
3877:
3875:
3872:
3871:
3867:
3864:
3861:
3859:
3856:
3853:
3851:
3848:
3845:
3843:
3842:
3838:
3837:
3833:
3830:
3827:
3825:
3822:
3819:
3817:
3816:Pezizomycetes
3814:
3811:
3809:
3808:
3804:
3803:
3799:
3796:
3793:
3791:
3788:
3785:
3783:
3780:
3778:C. confervae
3777:
3775:
3772:
3771:
3767:
3764:
3761:
3759:
3756:
3753:
3751:
3748:
3745:
3743:
3742:
3738:
3737:
3733:
3730:
3727:
3725:
3722:
3719:
3717:
3716:Rhabditophora
3714:
3711:
3709:
3708:
3704:
3703:
3699:
3696:
3693:
3691:
3688:
3685:
3683:
3680:
3677:
3675:
3674:
3670:
3669:
3665:
3662:
3659:
3657:
3654:
3651:
3649:
3646:
3643:
3641:
3638:
3637:
3633:
3630:
3627:
3625:
3622:
3619:
3617:
3614:
3611:
3609:
3608:
3604:
3603:
3599:
3596:
3593:
3591:
3588:
3585:
3583:
3580:
3578:Feather Star
3577:
3575:
3572:
3571:
3567:
3564:
3561:
3559:
3556:
3553:
3551:
3548:
3545:
3543:
3542:
3538:
3537:
3533:
3530:
3527:
3525:
3522:
3519:
3517:
3514:
3511:
3509:
3508:
3504:
3503:
3499:
3496:
3493:
3491:
3488:
3485:
3483:
3480:
3477:
3475:
3474:
3470:
3469:
3465:
3462:
3459:
3457:
3454:
3451:
3449:
3446:
3443:
3441:
3440:
3436:
3435:
3431:
3428:
3425:
3423:
3420:
3417:
3415:
3412:
3409:
3407:
3406:
3405:Gallus gallus
3402:
3401:
3397:
3394:
3391:
3389:
3386:
3383:
3380:
3377:
3375:
3374:
3370:
3369:
3365:
3362:
3359:
3357:
3354:
3351:
3348:
3345:
3343:
3342:
3338:
3337:
3333:
3330:
3327:
3325:
3322:
3319:
3316:
3313:
3311:
3310:
3306:
3305:
3301:
3298:
3295:
3293:
3290:
3287:
3285:
3282:
3279:
3277:
3276:
3272:
3271:
3267:
3264:
3261:
3258:
3255:
3252:
3249:
3246:
3245:
3239:
3237:
3233:
3229:
3228:invertebrates
3225:
3221:
3217:
3213:
3209:
3201:
3194:
3191:
3188:
3186:
3183:
3180:
3177:
3176:
3172:
3169:
3166:
3164:
3161:
3158:
3155:
3154:
3150:
3147:
3144:
3141:
3138:
3135:
3134:
3128:
3126:
3122:
3117:
3115:
3111:
3107:
3103:
3096:
3091:
3089:
3087:
3083:
3079:
3075:
3071:
3067:
3063:
3059:
3055:
3051:
3047:
3043:
3038:
3034:
3030:
3023:
3019:
3012:
3010:
3008:
3004:
3000:
2996:
2992:
2988:
2981:
2978:
2973:
2971:
2969:
2964:
2960:
2953:
2949:
2942:
2935:
2932:
2930:
2927:
2926:
2922:
2919:
2917:
2914:
2913:
2909:
2906:
2904:
2901:
2900:
2896:
2893:
2891:
2888:
2887:
2883:
2880:
2878:
2875:
2874:
2870:
2867:
2865:
2862:
2861:
2857:
2854:
2852:
2849:
2848:
2844:
2841:
2839:
2838:hsa-miR-4477b
2836:
2835:
2831:
2828:
2826:
2823:
2822:
2818:
2815:
2813:
2810:
2809:
2805:
2802:
2800:
2797:
2796:
2792:
2789:
2787:
2784:
2783:
2780:
2777:
2774:
2771:
2770:
2764:
2762:
2758:
2757:RNA silencing
2754:
2746:
2739:
2736:
2733:
2729:
2726:
2725:
2721:
2718:
2715:
2711:
2707:
2706:poly(A) tails
2703:
2700:
2697:
2696:
2692:
2689:
2686:
2682:
2681:tumorigenesis
2678:
2674:
2671:
2668:
2667:
2663:
2660:
2657:
2654:
2651:
2650:
2646:
2643:
2640:
2637:
2636:
2632:
2629:
2626:
2623:
2622:
2618:
2615:
2612:
2609:
2606:
2605:
2601:
2598:
2596:
2592:
2588:
2584:
2581:
2578:
2577:
2573:
2570:
2567:
2563:
2559:
2555:
2551:
2548:
2545:
2544:
2540:
2537:
2534:
2531:
2530:
2519:
2516:
2513:
2509:
2506:
2503:
2502:
2498:
2495:
2493:
2489:
2485:
2481:
2478:
2475:
2474:
2470:
2467:
2464:
2461:
2460:
2456:
2453:
2450:
2446:
2443:
2440:
2439:
2435:
2432:
2429:
2426:
2425:
2421:
2418:
2415:
2412:
2409:
2408:
2404:
2401:
2398:
2394:
2391:
2388:
2387:
2383:
2380:
2378:
2374:
2373:polyribosomes
2370:
2366:
2363:
2360:
2359:
2355:
2352:
2349:
2348:mitochondrial
2345:
2341:
2338:
2335:
2334:
2331:
2327:
2324:
2322:
2318:
2314:
2311:
2308:
2307:
2303:
2300:
2297:
2294:
2293:
2287:
2285:
2281:
2277:
2273:
2269:
2265:
2261:
2254:
2249:
2247:
2245:
2241:
2237:
2233:
2229:
2225:
2224:spinal column
2221:
2217:
2210:
2206:
2202:
2200:
2196:
2192:
2188:
2184:
2180:
2176:
2172:
2171:smooth muscle
2168:
2164:
2160:
2157:
2153:
2149:
2145:
2141:
2137:
2133:
2129:
2125:
2121:
2117:
2116:adrenal gland
2113:
2109:
2105:
2101:
2097:
2093:
2087:
2083:
2076:
2069:
2066:
2064:
2061:
2060:
2056:
2053:
2050:
2049:
2045:
2042:
2040:
2037:
2036:
2032:
2029:
2027:
2024:
2023:
2019:
2016:
2014:
2011:
2010:
2007:
2003:
2000:
1997:
1996:
1993:
1990:
1986:
1983:
1980:
1979:
1975:
1972:
1969:
1968:
1964:
1961:
1959:
1956:
1955:
1951:
1948:
1946:
1943:
1942:
1938:
1935:
1933:
1930:
1929:
1925:
1922:
1919:
1918:
1914:
1911:
1909:
1906:
1905:
1901:
1898:
1895:
1894:
1890:
1887:
1885:
1882:
1881:
1877:
1874:
1872:
1868:
1865:
1864:
1860:
1857:
1855:
1852:
1851:
1847:
1844:
1841:
1840:
1836:
1833:
1831:
1828:
1827:
1823:
1820:
1817:
1816:
1810:
1808:
1804:
1800:
1796:
1792:
1788:
1784:
1780:
1776:
1772:
1768:
1764:
1760:
1756:
1749:
1747:
1739:
1736:
1733:
1730:
1727:
1724:
1723:
1719:
1716:
1713:
1710:
1707:
1704:
1703:
1699:
1696:
1693:
1690:
1687:
1684:
1683:
1679:
1676:
1673:
1670:
1667:
1664:
1663:
1659:
1656:
1653:
1650:
1647:
1644:
1643:
1637:
1631:
1626:
1621:
1614:
1611:
1608:
1605:
1604:
1600:
1597:
1594:
1591:
1590:
1586:
1583:
1580:
1577:
1576:
1572:
1570:Cluster Size
1569:
1567:
1564:
1561:
1560:
1554:
1551:
1547:
1543:
1539:
1535:
1527:
1523:
1517:
1513:
1506:
1504:
1502:
1498:
1494:
1490:
1486:
1480:
1476:
1472:
1470:
1466:
1462:
1458:
1454:
1450:
1446:
1439:
1435:
1428:
1426:
1424:
1420:
1416:
1413:
1409:
1405:
1401:
1397:
1393:
1389:
1385:
1381:
1373:
1369:
1361:
1357:
1353:
1351:
1347:
1346:lipid bilayer
1343:
1339:
1335:
1334:phenylalanine
1331:
1327:
1323:
1319:
1316:(MW) of 51.5
1315:
1311:
1307:
1299:
1297:
1295:
1285:
1282:
1280:
1277:
1274:
1273:
1269:
1266:
1264:
1261:
1258:
1257:
1253:
1250:
1248:
1247:
1243:
1240:
1237:
1236:
1232:
1229:
1226:
1223:
1222:
1216:
1210:
1205:
1203:
1195:
1192:
1190:
1187:
1184:
1183:
1179:
1175:
1172:
1170:
1167:
1164:
1163:
1159:
1155:
1151:
1148:
1146:
1143:
1140:
1139:
1135:
1131:
1128:
1125:
1123:
1120:
1117:
1116:
1112:
1109:
1106:
1103:
1102:
1096:
1094:
1091:
1087:
1083:
1075:
1070:
1068:
1066:
1062:
1058:
1054:
1050:
1046:
1042:
1038:
1029:
1027:
1025:
1021:
1017:
1013:
1009:
1005:
1001:
997:
993:
989:
985:
981:
977:
973:
970:
966:
962:
958:
954:
950:
946:
942:
930:
925:
921:
917:
914:
910:
903:
901:
898:
894:
890:
886:
883:
879:
875:
868:
866:
862:
856:
852:
849:
843:
841:
837:
833:
827:
823:
820:
816:
809:
807:
803:
797:
793:
790:
784:
782:
778:
774:
768:
764:
761:
759:RefSeq (mRNA)
757:
750:
749:
744:
740:
737:
731:
730:
725:
721:
718:
716:
712:
705:
704:
699:
695:
692:
686:
685:
680:
676:
673:
671:
667:
660:
659:
654:
650:
647:
641:
640:
635:
631:
628:
626:
622:
619:
616:
614:
611:
607:
604:
600:
596:
589:
585:
580:
574:
571:
569:
566:
565:
563:
560:
559:
553:
550:
548:
545:
543:
540:
539:
537:
534:
533:
527:
524:
523:
521:
518:
517:
514:
513:Gene ontology
510:
506:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
441:parotid gland
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
391:kidney tubule
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
8872:
8869:BMC Genomics
8868:
8829:
8825:
8784:
8780:
8770:
8733:
8729:
8719:
8684:
8680:
8670:
8661:
8652:
8607:
8603:
8593:
8572:cite journal
8545:
8500:
8482:
8473:
8438:
8434:
8424:
8415:
8406:
8397:
8388:
8345:
8341:
8331:
8310:cite journal
8286:
8277:
8268:
8257:. Retrieved
8237:
8233:
8223:
8196:
8192:
8144:
8140:
8092:
8088:
8078:
8051:
8047:
8037:
8012:
8008:
7962:
7959:ACS Cent Sci
7958:
7948:
7939:
7930:
7921:
7912:
7877:
7873:
7863:
7828:
7824:
7814:
7787:
7783:
7773:
7733:(1): 28249.
7730:
7726:
7716:
7679:
7675:
7665:
7638:
7635:Glycobiology
7634:
7624:
7591:
7587:
7581:
7556:
7552:
7546:
7512:(1): 72–80.
7509:
7505:
7495:
7458:
7454:
7444:
7409:
7403:
7358:
7353:
7318:
7314:
7304:
7277:
7271:
7246:
7242:
7236:
7203:
7199:
7186:
7151:
7147:
7141:
7114:
7108:
7073:
7069:
7059:
7032:
7027:
6992:
6988:
6978:
6969:
6960:
6925:
6921:
6911:
6876:
6872:
6862:
6827:
6823:
6773:
6769:
6759:
6750:
6741:
6732:
6723:
6714:
6705:
6696:
6687:
6642:
6638:
6628:
6591:
6587:
6577:
6568:
6559:
6526:
6522:
6515:
6480:
6476:
6466:
6431:
6427:
6417:
6408:
6329:
6323:
6288:
6284:
6274:
6239:
6235:
6225:
6216:
6169:
6165:
6155:
6120:
6116:
6106:
6097:
6088:
6054:(6): 884–6.
6051:
6047:
6037:
6012:
6008:
6002:
5975:
5969:
5936:
5932:
5926:
5884:(1): 140–4.
5881:
5877:
5867:
5858:
5849:
5814:
5810:
5788:
5779:
5744:
5740:
5700:
5696:
5673:
5666:
5640:
5634:
5589:
5585:
5557:
5536:
5515:
5492:
5483:
5474:
5465:
5456:
5447:
5438:
5416:
5405:
5394:. Retrieved
5390:the original
5385:
5362:
5353:
5344:
5335:
5326:
5299:
5290:
5247:
5243:
5191:
5187:
5145:
5141:
5089:
5085:
5027:
5023:
5001:
4958:
4954:
4896:
4892:
4852:
4848:
4826:
4805:
4784:
4743:
4737:
4728:
4707:
4680:
4671:
4662:
4653:
4574:pathogenesis
4571:
4559:triglyceride
4536:
4527:
4507:
4487:
4467:
4443:cytotoxicity
4436:
4433:Cancer/Tumor
4423:
4413:
4408:
4404:
4391:
4366:rs1342327615
4343:rs1373735793
4297:rs1403613207
4220:rs1456067444
4214:Description
4205:Base Change
4185:
4137:glioblastoma
4105:
4067:, forms the
4039:
4015:
4006:maytansinoid
3982:
3967:
3954:cytochrome c
3950:
3945:
3903:
3878:Black Yeast
3873:
3846:C. bantiana
3839:
3805:
3773:
3739:
3705:
3671:
3639:
3605:
3573:
3546:Whale Shark
3539:
3505:
3471:
3437:
3403:
3371:
3346:House Mouse
3341:Mus musculus
3339:
3307:
3275:Homo sapiens
3273:
3250:Common Name
3205:
3118:
3100:
3026:
3021:
2984:
2956:
2951:
2903:hsa-miR-6071
2864:hsa-miR-4319
2825:hsa-miR-5680
2779:Target Score
2750:
2716:transcripts
2708:and directs
2564:and protein
2554:hydroquinone
2535:Description
2329:
2298:Description
2258:
2214:
2208:
2090:
2085:
2005:
1991:
1988:
1821:Description
1753:
1745:
1740:GXT_2781071
1720:GXT_2781051
1700:GXT_2785139
1657:Length (bp)
1635:
1531:
1525:
1515:
1483:
1478:
1449:random coils
1442:
1437:
1365:
1359:
1320:. The basal
1303:
1291:
1244:
1230:Length (aa)
1214:
1201:
1130:MANE select.
1113:Description
1110:Length (bp)
1084:regions and
1079:
1033:
940:
939:
865:NP_001343931
858:
840:NP_001334889
832:NP_001129391
829:
806:NM_001357002
799:
781:NM_001347960
773:NM_001135919
770:
746:
727:
701:
682:
656:
637:
617:
612:
445:right kidney
333:
326:
292:147,831,625
279:147,815,247
53:External IDs
8687:(1): 33–8.
8095:(1): 1–34.
7461:: 1308692.
4562:homeostasis
4553:as well as
4458:trastuzumab
4414:frameshift
4393:rs751982648
4389:rs757225275
4334:frameshift
4320:rs764198426
4270:rs776889950
4247:rs749501877
4240:start codon
4020:(ETC) that
3750:Tricoplacia
3746:Trichoplax
3507:Danio rerio
3292:NP_861450.1
3185:NP_149040.3
3163:NP_542400.2
3086:lipid rafts
2585:subunit of
2568:activities
2397:spliceosome
2280:translation
2240:dorsal horn
2232:neural arch
2144:lymph nodes
1771:heterodimer
1708:GXP_190679
1688:GXP_190676
1668:GXP_190678
1660:Transcript
1465:amphipathic
1396:trafficking
1310:amino acids
1242:NP_861450.1
1233:Transcript
1122:NM_181785.4
383:gallbladder
271:5|5 G3
191:28,718,970
178:28,700,064
31:Identifiers
8913:Categories
8259:2020-08-01
7588:Proteomics
6594:(1): 263.
5396:2020-08-01
4961:: 108864.
4648:, May 2017
4627:, May 2017
4604:References
4582:SARS-CoV-2
4171:prohibitin
4073:covalently
4026:glycolytic
3985:maytansine
3920:GES65939.1
3888:RVX69813.1
3824:PWW79074.1
3790:TPX75507.1
3724:AKN21695.1
3644:Fruit Fly
3512:Zebrafish
3220:amphibians
3125:2'3'-cGAMP
3110:antifolate
3044:at Thr25.
2714:eukaryotic
2677:cell cycle
2350:regulator
2132:Microarray
2126:, kidney,
1728:GXP_19677
1489:N-terminus
1342:fatty acid
1326:substrates
1300:Properties
1158:C-terminus
1154:frameshift
1071:Transcript
387:glomerulus
337:(ortholog)
74:HomoloGene
8564:219115750
7936:"SLC46A2"
7918:"SLC46A1"
7682:(1): 72.
7385:cite book
7377:960166742
7228:216678118
7178:0033-5770
6966:"SLC46A3"
6697:GenePaint
6693:"SLC46A3"
6384:ignored (
6374:cite book
6217:Zhang Lab
5412:Maglott D
5382:"SLC46A3"
5359:"SLC46A3"
5296:"SLC46A3"
4802:"SLC46A3"
4704:"SLC46A3"
4586:replicase
4518:sorafenib
4478:mutations
4412:missense
4380:missense
4357:missense
4311:missense
4291:-C motif
4284:missense
4261:missense
4211:Function
4143:patients.
4130:mast cell
4110:apoptosis
4071:(BCR) by
3993:macrolide
3712:Flatworm
3582:Crinoidea
3381:Mammalia
3378:Platypus
3349:Mammalia
3317:Mammalia
3202:Orthologs
3121:symporter
3070:glycation
2963:stem-loop
2920:GAGAACCA
2907:CAGCAGAA
2894:AGCAATAA
2868:CTCAGGGA
2790:ATGTTTCA
2488:platelets
2449:germ cell
2433:gguugguu
2317:pre-mRNAs
2266:regulate
2195:papilloma
2156:bronchial
2120:intestine
1807:CCAAT box
1783:repressor
1734:28705557
1731:28704518
1714:28714311
1711:28713272
1694:28715973
1691:28714934
1674:28720092
1671:28718802
1645:Promoter
1415:signaling
1368:glutamine
1057:orthologs
1012:biomarker
992:papilloma
969:α-helical
861:NP_082148
836:NP_861450
802:NM_027872
777:NM_181785
603:Orthologs
82:GeneCards
8901:19284880
8856:20708005
8803:17550900
8762:32547943
8711:24316979
8644:10393914
8537:17037506
8465:26186194
8380:32296183
8254:17168740
8215:30131388
8171:27530302
8070:28387841
7989:34235268
7904:25419213
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7538:32200042
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7436:11928486
7345:23584533
7263:15111065
7220:30778233
7100:12824337
7035:. 1993.
7019:26865341
6952:31504780
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6366:2119171
6357:1131717
6306:3789548
6257:5793808
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4120:, and
4091:LGALS3
4061:B-cell
4001:moiety
3280:Human
3222:, and
3106:folate
3003:myosin
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2699:PABPN1
2616:wcwwc
2538:Motif
2477:PABPC4
2451:mRNAs
2337:ZC3H10
2301:Motif
2264:3' UTR
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2234:, and
2199:glioma
2173:, and
2110:, and
2092:RNAseq
2070:0.982
2057:0.864
2046:0.908
2033:0.991
2020:0.855
2013:ZNF692
2006:0.934
2004:0.944
1992:0.955
1989:0.949
1987:0.983
1976:1.000
1965:0.986
1952:0.959
1939:0.758
1926:0.962
1915:0.852
1902:0.897
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1878:0.833
1861:0.983
1848:0.994
1842:c-Myc
1837:0.989
1651:Start
1550:ligand
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1090:RefSeq
1043:and 5
1024:kidney
1022:, and
1002:, and
996:glioma
980:breast
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748:Q9DC26
729:Q7Z3Q1
639:283537
625:Entrez
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8635:22154
8560:S2CID
8110:98904
7612:S2CID
7224:S2CID
7196:(PDF)
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3916:1105
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3884:1105
3854:1105
3820:1105
3786:1105
3236:BLAST
3212:birds
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2608:SRSF3
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2547:ENOX1
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2124:heart
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1884:RREB1
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1795:NF-YA
1737:1040
1717:1040
1697:1040
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