315:
292:
189:
214:
2415:
566:
2430:
26:
321:
220:
2455:
52:
2165:
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (Mar 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells".
1998:
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation".
2211:
Ohashi N, Yamamoto T, Uchida C, Togawa A, Fukasawa H, Fujigaki Y, Suzuki S, Kitagawa K, Hattori T, Oda T, Hayashi H, Hishida A, Kitagawa M (May 2005). "Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta".
1803:
Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL (Jun 2001). "TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation".
1376:
Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL (Jun 2001). "TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation".
2414:
328:
227:
1634:
Carpentier I, Coornaert B, Beyaert R (Oct 2008). "Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation".
2429:
869:
850:
150:
1558:
Lee YS, Han JM, Son SH, Choi JW, Jeon EJ, Bae SC, Park YI, Kim S (Jul 2008). "AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2".
1185:
1179:
1173:
1167:
2524:
2500:
2519:
2394:
1293:
1275:
1422:
Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T (Mar 2009).
314:
1084:
1077:
291:
2259:
Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di
Guglielmo GM, Kavsak P, Rasmussen RK, Seet BT, Sicheri F, Wrana JL (Aug 2005).
1359:
1320:"Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling"
1965:"Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation"
1262:
1241:
213:
188:
1258:
49:
2036:
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004).
1237:
130:
2296:"An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2"
1159:
327:
226:
1593:
Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T (Dec 2008).
2493:
1424:"Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins"
320:
219:
2387:
1669:
Emanuelli A, Borroni AP, Apel-Sarid L, Shah P, Manikoth
Ayyathan D, Koganti P, Levy-Cohen G, Blank M (Aug 2017).
914:
138:
895:
2081:"Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions"
2079:
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004).
1770:"Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation"
1514:"Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation"
2486:
1840:
Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A (Oct 2003).
202:
1595:"Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells"
2380:
2175:
1728:
117:
1885:"Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts"
1465:"Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts"
1060:
1009:
2360:
2247:
2199:
2024:
1951:
1926:
Li H, Seth A (Mar 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein".
1842:"The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase"
1828:
1401:
162:
1056:
1035:
1005:
984:
565:
2352:
2317:
2282:
2239:
2191:
2153:
2110:
2067:
2016:
1986:
1943:
1914:
1871:
1820:
1791:
1756:
1692:
1651:
1616:
1575:
1535:
1494:
1445:
1393:
1341:
110:
42:
2470:
2342:
2307:
2272:
2229:
2221:
2183:
2143:
2135:
2100:
2092:
2057:
2049:
2008:
1976:
1935:
1904:
1896:
1861:
1853:
1812:
1781:
1746:
1736:
1682:
1643:
1606:
1567:
1525:
1484:
1476:
1435:
1385:
1331:
407:
338:
282:
237:
158:
382:
2329:
Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD (Aug 2007).
2179:
1732:
25:
2423:: Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain
2261:"Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain"
1866:
1841:
2148:
2123:
2105:
2080:
2062:
2037:
1909:
1884:
1786:
1769:
1530:
1513:
1489:
1464:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
693:
688:
683:
678:
673:
668:
663:
658:
653:
637:
632:
627:
622:
617:
612:
607:
2513:
2466:
1768:
Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL (Dec 2000).
1751:
1716:
1512:
Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL (Dec 2000).
594:
2364:
2251:
2203:
2028:
1955:
1832:
1405:
142:
1671:"Smurf2-Mediated Stabilization of DNA Topoisomerase IIα Controls Genomic Integrity"
400:
179:
2225:
1687:
1670:
2277:
2260:
720:
negative regulation of transforming growth factor beta receptor signaling pathway
166:
1298:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1280:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1203:
2347:
2331:"Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain"
2330:
1721:
Proceedings of the
National Academy of Sciences of the United States of America
1717:"Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase"
1647:
1571:
483:
299:
196:
146:
2187:
1963:
Jin YH, Jeon EJ, Li QL, Lee YH, Choi JK, Kim WJ, Lee KY, Bae SC (Jul 2004).
814:
543:
421:
366:
353:
265:
252:
154:
2356:
2321:
2312:
2295:
2286:
2243:
2195:
2157:
2114:
2071:
2020:
1990:
1981:
1964:
1947:
1939:
1918:
1875:
1857:
1824:
1795:
1760:
1696:
1655:
1620:
1611:
1594:
1579:
1539:
1498:
1449:
1440:
1423:
1397:
1345:
1336:
1319:
1741:
1124:
1119:
1715:
Zhang Y, Chang C, Gehling DJ, Hemmati-Brivanlou A, Derynck R (Jan 2001).
1108:
959:
940:
2139:
740:
regulation of transforming growth factor beta receptor signaling pathway
2096:
2053:
926:
881:
87:
83:
79:
75:
71:
2234:
1900:
1816:
1480:
1389:
1197:
1140:
1092:
836:
2454:
2012:
2438:: Solution structure of Smurf2 WW3 domain-Smad7 PY peptide complex
1212:
1191:
1360:"Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2"
799:
795:
780:
proteasome-mediated ubiquitin-dependent protein catabolic process
2462:
1147:
574:
134:
2376:
2372:
2124:"Smurf2 up-regulation activates telomere-dependent senescence"
2038:"Functional proteomics mapping of a human signaling pathway"
715:
negative regulation of transcription by RNA polymerase II
390:
2474:
1883:
Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K (Jan 2004).
1463:
Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K (Jan 2004).
710:
positive regulation of canonical Wnt signaling pathway
2294:
Chong PA, Lin H, Wrana JL, Forman-Kay JD (Jun 2006).
555:
1636:
1560:
1049:
1028:
998:
977:
760:
Wnt signaling pathway, planar cell polarity pathway
750:
negative regulation of transcription, DNA-templated
1254:
1252:
1250:
1233:
1231:
1229:
735:ubiquitin-dependent SMAD protein catabolic process
730:positive regulation of trophoblast cell migration
337:
236:
785:positive regulation of protein catabolic process
633:transforming growth factor beta receptor binding
1553:
1551:
1549:
1417:
1415:
1371:
1369:
1313:
1311:
1309:
1307:
1259:GRCm38: Ensembl release 89: ENSMUSG00000018363
1150:which is located at chromosome 17q23.3-q24.1.
2494:
2388:
770:ubiquitin-dependent protein catabolic process
121:, SMAD specific E3 ubiquitin protein ligase 2
8:
775:negative regulation of BMP signaling pathway
1238:GRCh38: Ensembl release 89: ENSG00000108854
2501:
2487:
2395:
2381:
2373:
810:
590:
378:
277:
174:
60:
2346:
2311:
2276:
2233:
2147:
2104:
2061:
1980:
1908:
1865:
1785:
1750:
1740:
1686:
1610:
1529:
1488:
1439:
1335:
1186:Mothers against decapentaplegic homolog 7
1180:Mothers against decapentaplegic homolog 3
1174:Mothers against decapentaplegic homolog 2
1168:Mothers against decapentaplegic homolog 1
2410:
1225:
618:ubiquitin-protein transferase activity
15:
1889:The Journal of Clinical Investigation
1469:The Journal of Clinical Investigation
342:
303:
298:
241:
200:
195:
7:
2451:
2449:
1318:Lin X, Liang M, Feng XH (Nov 2000).
522:endothelial cell of lymphatic vessel
2300:The Journal of Biological Chemistry
1969:The Journal of Biological Chemistry
1599:The Journal of Biological Chemistry
1428:The Journal of Biological Chemistry
1324:The Journal of Biological Chemistry
2473:. You can help Knowledge (XXG) by
1137:E3 ubiquitin-protein ligase SMURF2
1046:
1025:
995:
974:
950:
931:
905:
886:
860:
841:
560:
478:
416:
395:
14:
1143:that in humans is encoded by the
628:ubiquitin protein ligase activity
2453:
2428:
2413:
564:
326:
319:
313:
290:
225:
218:
212:
187:
24:
2525:Human chromosome 17 gene stubs
2122:Zhang H, Cohen SN (Dec 2004).
575:More reference expression data
544:More reference expression data
1:
2226:10.1016/j.febslet.2005.03.069
1787:10.1016/S1097-2765(00)00134-9
1688:10.1158/0008-5472.CAN-16-2828
1531:10.1016/s1097-2765(00)00134-9
311:
210:
2520:Genes on human chromosome 17
2278:10.1016/j.molcel.2005.06.028
2541:
2448:
2348:10.1016/j.cell.2007.06.050
1648:10.1016/j.bbrc.2008.07.103
1572:10.1016/j.bbrc.2008.04.099
1085:Chr 11: 106.71 – 106.81 Mb
755:protein polyubiquitination
530:superior cervical ganglion
2408:
1846:British Journal of Cancer
1294:"Mouse PubMed Reference:"
1276:"Human PubMed Reference:"
1158:SMURF2 has been shown to
1123:
1118:
1114:
1107:
1091:
1072:
1053:
1032:
1021:
1002:
981:
970:
957:
953:
938:
934:
925:
912:
908:
893:
889:
880:
867:
863:
848:
844:
835:
820:
813:
809:
793:
613:identical protein binding
593:
589:
572:
563:
554:
541:
490:
481:
428:
419:
389:
381:
377:
360:
347:
310:
289:
280:
276:
259:
246:
209:
186:
177:
173:
128:
125:
115:
108:
103:
68:
63:
46:
41:
36:
32:
23:
18:
1078:Chr 17: 64.54 – 64.66 Mb
765:protein deubiquitination
664:ubiquitin ligase complex
2188:10.1126/science.1105776
2128:Genes & Development
2313:10.1074/jbc.M601493200
1982:10.1074/jbc.M313120200
1940:10.1038/sj.onc.1207319
1858:10.1038/sj.bjc.6601301
1612:10.1074/jbc.M710496200
1441:10.1074/jbc.M804659200
1337:10.1074/jbc.C000580200
745:protein ubiquitination
1742:10.1073/pnas.98.3.974
725:BMP signaling pathway
305:Chromosome 11 (mouse)
203:Chromosome 17 (human)
2001:Nature Biotechnology
623:transferase activity
64:List of PDB id codes
37:Available structures
2180:2005Sci...307.1621B
2140:10.1101/gad.1253004
1805:Nature Cell Biology
1733:2001PNAS...98..974Z
1378:Nature Cell Biology
2461:This article on a
2097:10.1101/gr.2435604
2054:10.1101/gr.2334104
915:ENSMUSG00000018363
703:Biological process
647:Cellular component
601:Molecular function
432:buccal mucosa cell
167:SMURF2 - orthologs
2482:
2481:
2446:
2445:
1681:(16): 4217–4227.
1134:
1133:
1130:
1129:
1103:
1102:
1068:
1067:
1043:
1042:
1017:
1016:
992:
991:
966:
965:
947:
946:
921:
920:
902:
901:
876:
875:
857:
856:
805:
804:
585:
584:
581:
580:
550:
549:
537:
536:
475:
474:
373:
372:
272:
271:
99:
98:
95:
94:
47:Ortholog search:
2532:
2503:
2496:
2489:
2457:
2450:
2432:
2417:
2397:
2390:
2383:
2374:
2368:
2350:
2325:
2315:
2306:(25): 17069–75.
2290:
2280:
2255:
2237:
2207:
2174:(5715): 1621–5.
2161:
2151:
2118:
2108:
2075:
2065:
2032:
1994:
1984:
1975:(28): 29409–17.
1959:
1922:
1912:
1901:10.1172/JCI16269
1879:
1869:
1836:
1817:10.1038/35078562
1799:
1789:
1764:
1754:
1744:
1701:
1700:
1690:
1666:
1660:
1659:
1631:
1625:
1624:
1614:
1590:
1584:
1583:
1555:
1544:
1543:
1533:
1509:
1503:
1502:
1492:
1481:10.1172/JCI16269
1460:
1454:
1453:
1443:
1419:
1410:
1409:
1390:10.1038/35078562
1373:
1364:
1363:
1356:
1350:
1349:
1339:
1330:(47): 36818–22.
1315:
1302:
1301:
1290:
1284:
1283:
1272:
1266:
1256:
1245:
1235:
1116:
1115:
1087:
1080:
1063:
1047:
1038:
1026:
1022:RefSeq (protein)
1012:
996:
987:
975:
951:
932:
906:
887:
861:
842:
811:
591:
577:
568:
561:
546:
526:genital tubercle
506:secondary oocyte
486:
484:Top expressed in
479:
464:caput epididymis
452:lactiferous duct
436:secondary oocyte
424:
422:Top expressed in
417:
396:
379:
369:
356:
345:
330:
323:
317:
306:
294:
278:
268:
255:
244:
229:
222:
216:
205:
191:
175:
169:
120:
113:
90:
61:
55:
34:
33:
28:
16:
2540:
2539:
2535:
2534:
2533:
2531:
2530:
2529:
2510:
2509:
2508:
2507:
2447:
2442:
2439:
2433:
2424:
2418:
2404:
2401:
2371:
2328:
2293:
2258:
2220:(12): 2557–63.
2210:
2164:
2134:(24): 3028–40.
2121:
2085:Genome Research
2078:
2042:Genome Research
2035:
1997:
1962:
1925:
1882:
1839:
1802:
1767:
1714:
1710:
1708:Further reading
1705:
1704:
1675:Cancer Research
1668:
1667:
1663:
1633:
1632:
1628:
1605:(51): 35660–7.
1592:
1591:
1587:
1557:
1556:
1547:
1511:
1510:
1506:
1462:
1461:
1457:
1434:(10): 6109–15.
1421:
1420:
1413:
1375:
1374:
1367:
1358:
1357:
1353:
1317:
1316:
1305:
1292:
1291:
1287:
1274:
1273:
1269:
1257:
1248:
1236:
1227:
1222:
1209:
1156:
1125:View/Edit Mouse
1120:View/Edit Human
1083:
1076:
1073:Location (UCSC)
1059:
1055:
1034:
1008:
1004:
983:
896:ENSG00000108854
789:
698:
669:plasma membrane
642:
608:protein binding
573:
542:
533:
528:
524:
520:
518:right lung lobe
516:
512:
508:
504:
500:
496:
482:
471:
468:Achilles tendon
466:
462:
458:
456:visceral pleura
454:
450:
446:
442:
438:
434:
420:
364:
351:
343:
333:
332:
331:
324:
304:
281:Gene location (
263:
250:
242:
232:
231:
230:
223:
201:
178:Gene location (
129:
116:
109:
70:
48:
12:
11:
5:
2538:
2536:
2528:
2527:
2522:
2512:
2511:
2506:
2505:
2498:
2491:
2483:
2480:
2479:
2458:
2444:
2443:
2441:
2440:
2434:
2427:
2425:
2419:
2412:
2409:
2406:
2405:
2402:
2400:
2399:
2392:
2385:
2377:
2370:
2369:
2326:
2291:
2271:(3): 297–308.
2265:Molecular Cell
2256:
2208:
2162:
2119:
2076:
2048:(7): 1324–32.
2033:
2013:10.1038/nbt971
1995:
1960:
1934:(10): 1801–8.
1923:
1880:
1852:(8): 1538–44.
1837:
1800:
1780:(6): 1365–75.
1774:Molecular Cell
1765:
1711:
1709:
1706:
1703:
1702:
1661:
1626:
1585:
1566:(3): 395–400.
1545:
1524:(6): 1365–75.
1518:Molecular Cell
1504:
1455:
1411:
1365:
1351:
1303:
1285:
1267:
1246:
1224:
1223:
1221:
1218:
1217:
1216:
1208:
1207:
1201:
1195:
1189:
1183:
1177:
1171:
1164:
1155:
1152:
1132:
1131:
1128:
1127:
1122:
1112:
1111:
1105:
1104:
1101:
1100:
1098:
1096:
1089:
1088:
1081:
1074:
1070:
1069:
1066:
1065:
1051:
1050:
1044:
1041:
1040:
1030:
1029:
1023:
1019:
1018:
1015:
1014:
1000:
999:
993:
990:
989:
979:
978:
972:
968:
967:
964:
963:
955:
954:
948:
945:
944:
936:
935:
929:
923:
922:
919:
918:
910:
909:
903:
900:
899:
891:
890:
884:
878:
877:
874:
873:
865:
864:
858:
855:
854:
846:
845:
839:
833:
832:
827:
822:
818:
817:
807:
806:
803:
802:
791:
790:
788:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
706:
704:
700:
699:
697:
696:
691:
686:
681:
676:
671:
666:
661:
656:
650:
648:
644:
643:
641:
640:
635:
630:
625:
620:
615:
610:
604:
602:
598:
597:
587:
586:
583:
582:
579:
578:
570:
569:
558:
552:
551:
548:
547:
539:
538:
535:
534:
532:
531:
527:
523:
519:
515:
514:left lung lobe
511:
507:
503:
499:
495:
491:
488:
487:
476:
473:
472:
470:
469:
465:
461:
457:
453:
449:
448:saphenous vein
445:
441:
440:amniotic fluid
437:
433:
429:
426:
425:
413:
412:
404:
393:
387:
386:
383:RNA expression
375:
374:
371:
370:
362:
358:
357:
349:
346:
341:
335:
334:
325:
318:
312:
308:
307:
302:
296:
295:
287:
286:
274:
273:
270:
269:
261:
257:
256:
248:
245:
240:
234:
233:
224:
217:
211:
207:
206:
199:
193:
192:
184:
183:
171:
170:
127:
123:
122:
114:
106:
105:
101:
100:
97:
96:
93:
92:
66:
65:
57:
56:
45:
39:
38:
30:
29:
21:
20:
13:
10:
9:
6:
4:
3:
2:
2537:
2526:
2523:
2521:
2518:
2517:
2515:
2504:
2499:
2497:
2492:
2490:
2485:
2484:
2478:
2476:
2472:
2468:
2467:chromosome 17
2464:
2459:
2456:
2452:
2437:
2431:
2426:
2422:
2416:
2411:
2407:
2398:
2393:
2391:
2386:
2384:
2379:
2378:
2375:
2366:
2362:
2358:
2354:
2349:
2344:
2341:(4): 651–62.
2340:
2336:
2332:
2327:
2323:
2319:
2314:
2309:
2305:
2301:
2297:
2292:
2288:
2284:
2279:
2274:
2270:
2266:
2262:
2257:
2253:
2249:
2245:
2241:
2236:
2231:
2227:
2223:
2219:
2215:
2209:
2205:
2201:
2197:
2193:
2189:
2185:
2181:
2177:
2173:
2169:
2163:
2159:
2155:
2150:
2145:
2141:
2137:
2133:
2129:
2125:
2120:
2116:
2112:
2107:
2102:
2098:
2094:
2091:(9): 1711–8.
2090:
2086:
2082:
2077:
2073:
2069:
2064:
2059:
2055:
2051:
2047:
2043:
2039:
2034:
2030:
2026:
2022:
2018:
2014:
2010:
2007:(6): 707–16.
2006:
2002:
1996:
1992:
1988:
1983:
1978:
1974:
1970:
1966:
1961:
1957:
1953:
1949:
1945:
1941:
1937:
1933:
1929:
1924:
1920:
1916:
1911:
1906:
1902:
1898:
1895:(2): 253–64.
1894:
1890:
1886:
1881:
1877:
1873:
1868:
1863:
1859:
1855:
1851:
1847:
1843:
1838:
1834:
1830:
1826:
1822:
1818:
1814:
1811:(6): 587–95.
1810:
1806:
1801:
1797:
1793:
1788:
1783:
1779:
1775:
1771:
1766:
1762:
1758:
1753:
1748:
1743:
1738:
1734:
1730:
1726:
1722:
1718:
1713:
1712:
1707:
1698:
1694:
1689:
1684:
1680:
1676:
1672:
1665:
1662:
1657:
1653:
1649:
1645:
1641:
1637:
1630:
1627:
1622:
1618:
1613:
1608:
1604:
1600:
1596:
1589:
1586:
1581:
1577:
1573:
1569:
1565:
1561:
1554:
1552:
1550:
1546:
1541:
1537:
1532:
1527:
1523:
1519:
1515:
1508:
1505:
1500:
1496:
1491:
1486:
1482:
1478:
1475:(2): 253–64.
1474:
1470:
1466:
1459:
1456:
1451:
1447:
1442:
1437:
1433:
1429:
1425:
1418:
1416:
1412:
1407:
1403:
1399:
1395:
1391:
1387:
1384:(6): 587–95.
1383:
1379:
1372:
1370:
1366:
1361:
1355:
1352:
1347:
1343:
1338:
1333:
1329:
1325:
1321:
1314:
1312:
1310:
1308:
1304:
1299:
1295:
1289:
1286:
1281:
1277:
1271:
1268:
1264:
1260:
1255:
1253:
1251:
1247:
1243:
1239:
1234:
1232:
1230:
1226:
1219:
1214:
1211:
1210:
1205:
1202:
1199:
1196:
1193:
1190:
1187:
1184:
1181:
1178:
1175:
1172:
1169:
1166:
1165:
1163:
1161:
1153:
1151:
1149:
1146:
1142:
1138:
1126:
1121:
1117:
1113:
1110:
1106:
1099:
1097:
1094:
1090:
1086:
1082:
1079:
1075:
1071:
1064:
1062:
1058:
1052:
1048:
1045:
1039:
1037:
1031:
1027:
1024:
1020:
1013:
1011:
1007:
1001:
997:
994:
988:
986:
980:
976:
973:
971:RefSeq (mRNA)
969:
962:
961:
956:
952:
949:
943:
942:
937:
933:
930:
928:
924:
917:
916:
911:
907:
904:
898:
897:
892:
888:
885:
883:
879:
872:
871:
866:
862:
859:
853:
852:
847:
843:
840:
838:
834:
831:
828:
826:
823:
819:
816:
812:
808:
801:
797:
792:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
707:
705:
702:
701:
695:
692:
690:
687:
685:
684:nuclear speck
682:
680:
679:membrane raft
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
651:
649:
646:
645:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
605:
603:
600:
599:
596:
595:Gene ontology
592:
588:
576:
571:
567:
562:
559:
557:
553:
545:
540:
529:
525:
521:
517:
513:
509:
505:
501:
498:otolith organ
497:
493:
492:
489:
485:
480:
477:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
430:
427:
423:
418:
415:
414:
411:
409:
405:
403:
402:
398:
397:
394:
392:
388:
384:
380:
376:
368:
363:
359:
355:
350:
344:11|11 E1
340:
336:
329:
322:
316:
309:
301:
297:
293:
288:
284:
279:
275:
267:
262:
258:
254:
249:
243:17q23.3-q24.1
239:
235:
228:
221:
215:
208:
204:
198:
194:
190:
185:
181:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
124:
119:
112:
107:
102:
91:
89:
85:
81:
77:
73:
67:
62:
59:
58:
54:
51:
44:
40:
35:
31:
27:
22:
17:
2475:expanding it
2460:
2435:
2420:
2338:
2334:
2303:
2299:
2268:
2264:
2217:
2214:FEBS Letters
2213:
2171:
2167:
2131:
2127:
2088:
2084:
2045:
2041:
2004:
2000:
1972:
1968:
1931:
1927:
1892:
1888:
1849:
1845:
1808:
1804:
1777:
1773:
1727:(3): 974–9.
1724:
1720:
1678:
1674:
1664:
1642:(4): 752–7.
1639:
1635:
1629:
1602:
1598:
1588:
1563:
1559:
1521:
1517:
1507:
1472:
1468:
1458:
1431:
1427:
1381:
1377:
1354:
1327:
1323:
1297:
1288:
1279:
1270:
1157:
1154:Interactions
1144:
1136:
1135:
1061:NP_001349823
1054:
1033:
1010:NM_001362894
1003:
982:
958:
939:
913:
894:
868:
849:
829:
824:
638:SMAD binding
406:
399:
365:106,811,541
352:106,710,892
126:External IDs
69:
2403:PDB gallery
1204:Ubiquitin C
674:nucleoplasm
460:pericardium
264:64,662,307
251:64,542,282
104:Identifiers
2514:Categories
1265:, May 2017
1244:, May 2017
1220:References
410:(ortholog)
147:HomoloGene
2465:on human
2235:10271/283
1057:NP_079757
1036:NP_073576
1006:NM_025481
985:NM_022739
815:Orthologs
694:cytoplasm
155:GeneCards
2365:16684837
2357:17719543
2322:16641086
2287:16061177
2252:38498506
2244:15862290
2204:39457788
2196:15761153
2158:15574587
2115:15342556
2072:15231748
2029:27764390
2021:15146197
1991:15138260
1956:37253372
1948:14755250
1928:Oncogene
1919:14722617
1876:14562029
1833:23270947
1825:11389444
1796:11163210
1761:11158580
1697:28611047
1656:18671942
1621:18927080
1580:18448069
1540:11163210
1499:14722617
1450:19122240
1406:23270947
1398:11389444
1346:11016919
1261:–
1240:–
1160:interact
1109:Wikidata
794:Sources:
659:membrane
2176:Bibcode
2168:Science
1867:2394340
1729:Bibcode
1263:Ensembl
1242:Ensembl
927:UniProt
882:Ensembl
821:Species
800:QuickGO
689:nucleus
654:cytosol
502:utricle
444:pylorus
385:pattern
143:1913563
111:Aliases
2363:
2355:
2320:
2285:
2250:
2242:
2202:
2194:
2156:
2149:535914
2146:
2113:
2106:515316
2103:
2070:
2063:442148
2060:
2027:
2019:
1989:
1954:
1946:
1917:
1910:310747
1907:
1874:
1864:
1831:
1823:
1794:
1759:
1749:
1695:
1654:
1619:
1578:
1538:
1497:
1490:310747
1487:
1448:
1404:
1396:
1344:
1200:, and
1198:SMURF1
1162:with:
1145:SMURF2
1141:enzyme
1139:is an
1095:search
1093:PubMed
960:A2A5Z6
941:Q9HAU4
837:Entrez
556:BioGPS
510:zygote
159:SMURF2
135:605532
118:SMURF2
19:SMURF2
2469:is a
2361:S2CID
2248:S2CID
2200:S2CID
2025:S2CID
1952:S2CID
1829:S2CID
1752:14694
1402:S2CID
1213:TOP2A
1192:SCYE1
870:66313
851:64750
830:Mouse
825:Human
796:Amigo
408:Mouse
401:Human
348:Start
283:Mouse
247:Start
180:Human
151:41490
2471:stub
2463:gene
2436:2djy
2421:1zvd
2353:PMID
2335:Cell
2318:PMID
2283:PMID
2240:PMID
2192:PMID
2154:PMID
2111:PMID
2068:PMID
2017:PMID
1987:PMID
1944:PMID
1915:PMID
1872:PMID
1821:PMID
1792:PMID
1757:PMID
1693:PMID
1652:PMID
1617:PMID
1576:PMID
1536:PMID
1495:PMID
1446:PMID
1394:PMID
1342:PMID
1148:gene
494:hand
391:Bgee
339:Band
300:Chr.
238:Band
197:Chr.
131:OMIM
88:2LTZ
84:2KXQ
80:2JQZ
76:2DJY
72:1ZVD
53:RCSB
50:PDBe
2343:doi
2339:130
2308:doi
2304:281
2273:doi
2230:hdl
2222:doi
2218:579
2184:doi
2172:307
2144:PMC
2136:doi
2101:PMC
2093:doi
2058:PMC
2050:doi
2009:doi
1977:doi
1973:279
1936:doi
1905:PMC
1897:doi
1893:113
1862:PMC
1854:doi
1813:doi
1782:doi
1747:PMC
1737:doi
1683:doi
1644:doi
1640:374
1607:doi
1603:283
1568:doi
1564:371
1526:doi
1485:PMC
1477:doi
1473:113
1436:doi
1432:284
1386:doi
1332:doi
1328:275
361:End
260:End
163:OMA
139:MGI
43:PDB
2516::
2359:.
2351:.
2337:.
2333:.
2316:.
2302:.
2298:.
2281:.
2269:19
2267:.
2263:.
2246:.
2238:.
2228:.
2216:.
2198:.
2190:.
2182:.
2170:.
2152:.
2142:.
2132:18
2130:.
2126:.
2109:.
2099:.
2089:14
2087:.
2083:.
2066:.
2056:.
2046:14
2044:.
2040:.
2023:.
2015:.
2005:22
2003:.
1985:.
1971:.
1967:.
1950:.
1942:.
1932:23
1930:.
1913:.
1903:.
1891:.
1887:.
1870:.
1860:.
1850:89
1848:.
1844:.
1827:.
1819:.
1807:.
1790:.
1776:.
1772:.
1755:.
1745:.
1735:.
1725:98
1723:.
1719:.
1691:.
1679:77
1677:.
1673:.
1650:.
1638:.
1615:.
1601:.
1597:.
1574:.
1562:.
1548:^
1534:.
1520:.
1516:.
1493:.
1483:.
1471:.
1467:.
1444:.
1430:.
1426:.
1414:^
1400:.
1392:.
1380:.
1368:^
1340:.
1326:.
1322:.
1306:^
1296:.
1278:.
1249:^
1228:^
798:/
367:bp
354:bp
266:bp
253:bp
161:;
157::
153:;
149::
145:;
141::
137:;
133::
86:,
82:,
78:,
74:,
2502:e
2495:t
2488:v
2477:.
2396:e
2389:t
2382:v
2367:.
2345::
2324:.
2310::
2289:.
2275::
2254:.
2232::
2224::
2206:.
2186::
2178::
2160:.
2138::
2117:.
2095::
2074:.
2052::
2031:.
2011::
1993:.
1979::
1958:.
1938::
1921:.
1899::
1878:.
1856::
1835:.
1815::
1809:3
1798:.
1784::
1778:6
1763:.
1739::
1731::
1699:.
1685::
1658:.
1646::
1623:.
1609::
1582:.
1570::
1542:.
1528::
1522:6
1501:.
1479::
1452:.
1438::
1408:.
1388::
1382:3
1362:.
1348:.
1334::
1300:.
1282:.
1215:,
1206:.
1194:,
1188:,
1182:,
1176:,
1170:,
285:)
182:)
165::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
