253:
230:
127:
152:
511:
504:
259:
158:
2567:"Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation"
1396:
Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (August 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3".
1922:
Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (October 1997). "Cloning and characterization of novel CIS family genes".
2291:
Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kile BJ, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M (March 1999).
2161:
Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A (June 1997).
1774:
Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A (June 1997).
1178:
Several recent viral studies have shown that viral genes, such as Tax gene product (Tax), encoded by HTLV-1, could hijack SOCS1 to inhibit host antiviral pathways, as a strategy to evade host immunity.
1175:
loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-γ action, which is required for normal postnatal growth and survival.
2723:"Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases"
2802:
266:
165:
1164:
2645:"Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance"
2431:
Yandava CN, Pillari A, Drazen JM (October 1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively".
2767:
1349:"A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors"
839:
2610:"Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal"
1563:"Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal"
820:
88:
2294:"The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation"
2795:
2565:
Kawazoe Y, Naka T, Fujimoto M, Kohzaki H, Morita Y, Narazaki M, Okumura K, Saitoh H, Nakagawa R, Uchiyama Y, Akira S, Kishimoto T (January 2001).
2678:
Bellezza I, Neuwirt H, Nemes C, Cavarretta IT, Puhr M, Steiner H, Minelli A, Bartsch G, Offner F, Hobisch A, Doppler W, Culig Z (December 2006).
3099:
1329:
1311:
1208:
252:
2945:
2788:
2345:
Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A (March 1999).
1684:
Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A (March 1999).
2081:
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation".
2893:
2680:"Suppressor of cytokine signaling-3 antagonizes cAMP effects on proliferation and apoptosis and is expressed in human prostate cancer"
2110:
Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ (June 1997).
1047:
1054:
229:
2978:
1144:
1875:"Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1"
1446:
1432:
1298:
1277:
2462:"Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway"
151:
126:
1294:
2721:
Neuwirt H, Puhr M, Santer FR, Susani M, Doppler W, Marcias G, Rauch V, Brugger M, Hobisch A, Kenner L, Culig Z (May 2009).
3031:
1273:
3109:
68:
1465:"Human T cell leukemia virus type 1 Tax inhibits innate antiviral signaling via NF-kappaB-dependent induction of SOCS1"
1188:
265:
164:
1958:
Ohya K, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H (October 1997).
2811:
1250:
258:
157:
2850:
2845:
2215:"Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor"
884:
76:
3104:
2347:"The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop"
1686:"The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop"
1213:
865:
1171:(IFN-γ). The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a
2388:
Marine JC, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D, Yoshimura A, Ihle JN (September 1999).
2819:
140:
1347:
Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A (June 1995).
2305:
2175:
2123:
1788:
55:
1026:
975:
1834:"Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling"
2497:"SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms"
2419:
2250:"Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation"
2201:
2149:
2069:
1814:
1604:"SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms"
1514:"Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation"
100:
1735:"Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor"
1030:
1005:
979:
954:
59:, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3, suppressor of cytokine signaling 1, TIP-3, AISIMD
2883:
2837:
2752:
2709:
2666:
2631:
2596:
2553:
2518:
2483:
2448:
2411:
2376:
2333:
2279:
2236:
2193:
2141:
2098:
2061:
2026:
1981:
1940:
1904:
1855:
1806:
1756:
1715:
1666:
1645:"SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2"
1625:
1584:
1543:
1494:
1414:
1378:
1172:
510:
503:
48:
2742:
2734:
2699:
2691:
2656:
2621:
2586:
2578:
2543:
2508:
2473:
2440:
2401:
2366:
2358:
2323:
2313:
2269:
2261:
2226:
2183:
2131:
2090:
2051:
2016:
1971:
1932:
1894:
1886:
1845:
1796:
1746:
1705:
1697:
1656:
1615:
1574:
1533:
1525:
1484:
1476:
1406:
1368:
1360:
1196:
1168:
345:
276:
220:
175:
96:
1151:
signaling. The expression of this gene can be induced by a subset of cytokines, including
320:
2608:
Bourette RP, De
Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G (June 2001).
2248:
De
Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R (February 1999).
1561:
Bourette RP, De
Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G (June 2001).
1512:
De
Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R (February 1999).
2643:
Mooney RA, Senn J, Cameron S, Inamdar N, Boivin LM, Shang Y, Furlanetto RW (July 2001).
2309:
2179:
2127:
1792:
2878:
2873:
2868:
2747:
2722:
2704:
2679:
2591:
2566:
2371:
2346:
2274:
2249:
1710:
1685:
1538:
1513:
1489:
1464:
1364:
1225:
1160:
2478:
2461:
2406:
2389:
2094:
1899:
1874:
1373:
1348:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
623:
618:
613:
608:
603:
598:
593:
577:
572:
567:
562:
557:
552:
3093:
2771:
2328:
2293:
1890:
1156:
1152:
539:
2423:
2073:
80:
2902:
2860:
2205:
2153:
1818:
1140:
338:
117:
1147:(SOCS), family. SSI family members are cytokine-inducible negative regulators of
104:
3021:
2460:
Okabe S, Tauchi T, Morita H, Ohashi H, Yoshimura A, Ohyashiki K (October 1999).
1334:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1316:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2738:
2695:
2298:
Proceedings of the
National Academy of Sciences of the United States of America
2021:
2004:
421:
2362:
1701:
1231:
237:
134:
84:
2780:
2513:
2496:
2265:
2231:
2214:
1976:
1959:
1850:
1833:
1751:
1734:
1620:
1603:
1529:
2548:
2531:
1873:
Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O (May 2002).
1463:
Charoenthongtrakul S, Zhou Q, Shembade N, Harhaj NS, Harhaj EW (July 2011).
1124:
784:
481:
359:
304:
291:
203:
190:
92:
2756:
2713:
2670:
2661:
2644:
2635:
2626:
2609:
2600:
2557:
2522:
2487:
2452:
2444:
2415:
2380:
2337:
2318:
2283:
2102:
2065:
2030:
1936:
1908:
1859:
1760:
1719:
1670:
1661:
1644:
1629:
1588:
1579:
1562:
1547:
1498:
1410:
2582:
2240:
2197:
2145:
1985:
1944:
1810:
1418:
1382:
1094:
1089:
2827:
2532:"JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling"
1480:
1148:
1078:
929:
910:
2530:
Sporri B, Kovanen PE, Sasaki A, Yoshimura A, Leonard WJ (January 2001).
1960:"SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase"
1128:
1110:
896:
851:
2056:
2039:
705:
negative regulation of CD8-positive, alpha-beta T cell differentiation
700:
positive regulation of CD4-positive, alpha-beta T cell differentiation
1062:
806:
17:
2390:"SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality"
3016:
3011:
3006:
3001:
2996:
2991:
2986:
2968:
2963:
2958:
2953:
2935:
2930:
2925:
2920:
2915:
2910:
2188:
2164:"A new protein containing an SH2 domain that inhibits JAK kinases"
2163:
2136:
2111:
1801:
1777:"A new protein containing an SH2 domain that inhibits JAK kinases"
1776:
1202:
1733:
Dif F, Saunier E, Demeneix B, Kelly PA, Edery M (December 2001).
769:
765:
3074:
3069:
3064:
3059:
3054:
3049:
3044:
3039:
1245:
1219:
1117:
72:
2784:
1643:
Rui L, Yuan M, Frantz D, Shoelson S, White MF (November 2002).
695:
negative regulation of tyrosine phosphorylation of STAT protein
519:
2213:
Dey BR, Spence SL, Nissley P, Furlanetto RW (September 1998).
670:
negative regulation of receptor signaling pathway via JAK-STAT
2005:"SOCS proteins: negative regulators of cytokine signaling"
2112:"A family of cytokine-inducible inhibitors of signalling"
1187:
The suppressor of cytokine signaling 1 has been shown to
710:
negative regulation of insulin receptor signaling pathway
645:
regulation of interferon-gamma-mediated signaling pathway
2040:"Cytokine signaling in the brain: putting a SOCS in it?"
675:
positive regulation of regulatory T cell differentiation
328:
1447:"Entrez Gene: SOCS1 suppressor of cytokine signaling 1"
730:
regulation of tyrosine phosphorylation of STAT protein
1433:"OrthoMaM phylogenetic marker: SOCS1 coding sequence"
745:
regulation of receptor signaling pathway via JAK-STAT
493:
735:
regulation of phosphatidylinositol 3-kinase activity
3030:
2977:
2944:
2901:
2892:
2859:
2836:
2818:
1925:
1832:Pezet A, Favre H, Kelly PA, Edery M (August 1999).
1399:
1019:
998:
968:
947:
750:
phosphatidylinositol phosphate biosynthetic process
1290:
1288:
1286:
1269:
1267:
1265:
578:1-phosphatidylinositol-3-kinase regulator activity
720:regulation of activation of Janus kinase activity
275:
174:
27:Protein-coding gene in the species Homo sapiens
1458:
1456:
1295:GRCm38: Ensembl release 89: ENSMUSG00000038037
1131:for which complete genome data are available.
665:negative regulation of protein kinase activity
2796:
1143:-induced STAT inhibitor (SSI), also known as
8:
1274:GRCh38: Ensembl release 89: ENSG00000185338
553:insulin-like growth factor receptor binding
2898:
2803:
2789:
2781:
2768:United States National Library of Medicine
780:
660:negative regulation of signal transduction
535:
316:
215:
112:
2746:
2703:
2660:
2625:
2590:
2547:
2512:
2477:
2405:
2370:
2327:
2317:
2273:
2230:
2187:
2135:
2055:
2020:
1975:
1898:
1849:
1800:
1750:
1709:
1660:
1619:
1578:
1537:
1488:
1372:
2766:This article incorporates text from the
755:cellular response to amino acid stimulus
680:interleukin-7-mediated signaling pathway
1261:
715:receptor signaling pathway via JAK-STAT
725:negative regulation of kinase activity
29:
2038:Wang J, Campbell IL (February 2002).
685:regulation of protein phosphorylation
624:phosphatidylinositol 3-kinase complex
619:cytoplasmic ribonucleoprotein granule
280:
241:
236:
179:
138:
133:
7:
2571:The Journal of Experimental Medicine
1209:Colony stimulating factor 1 receptor
2649:The Journal of Biological Chemistry
2614:The Journal of Biological Chemistry
2501:The Journal of Biological Chemistry
2495:Ram PA, Waxman DJ (December 1999).
2219:The Journal of Biological Chemistry
1964:The Journal of Biological Chemistry
1838:The Journal of Biological Chemistry
1649:The Journal of Biological Chemistry
1608:The Journal of Biological Chemistry
1602:Ram PA, Waxman DJ (December 1999).
1567:The Journal of Biological Chemistry
690:cytokine-mediated signaling pathway
1365:10.1002/j.1460-2075.1995.tb07281.x
1139:This gene encodes a member of the
1107:Suppressor of cytokine signaling 1
1016:
995:
965:
944:
920:
901:
875:
856:
830:
811:
498:
416:
354:
333:
25:
2727:The American Journal of Pathology
2684:The American Journal of Pathology
1145:suppressor of cytokine signalling
1113:that in humans is encoded by the
640:intracellular signal transduction
558:protein kinase inhibitor activity
2044:Journal of Neuroscience Research
1891:10.1128/mcb.22.10.3316-3326.2002
1127:have been identified in several
509:
502:
264:
257:
251:
228:
163:
156:
150:
125:
2083:Trends in Biochemical Sciences
1879:Molecular and Cellular Biology
520:More reference expression data
482:More reference expression data
1:
2479:10.1016/S0301-472X(99)00094-6
2407:10.1016/S0092-8674(00)80048-3
2095:10.1016/S0968-0004(02)02085-6
249:
148:
3100:Genes on human chromosome 16
2003:Krebs DL, Hilton DJ (2001).
394:superficial temporal artery
3126:
2812:JAK-STAT signaling pathway
2739:10.2353/ajpath.2009.080751
2696:10.2353/ajpath.2006.060171
2022:10.1634/stemcells.19-5-378
1251:JAK-STAT signaling pathway
2851:Type II cytokine receptor
1330:"Mouse PubMed Reference:"
1312:"Human PubMed Reference:"
1093:
1088:
1084:
1077:
1061:
1042:
1023:
1002:
991:
972:
951:
940:
927:
923:
908:
904:
895:
882:
878:
863:
859:
850:
837:
833:
818:
814:
805:
790:
783:
779:
763:
573:kinase inhibitor activity
538:
534:
517:
501:
492:
479:
428:
419:
366:
357:
327:
319:
315:
298:
285:
248:
227:
218:
214:
197:
184:
147:
124:
115:
111:
66:
63:
53:
46:
41:
37:
32:
2846:Type I cytokine receptor
2514:10.1074/jbc.274.50.35553
2232:10.1074/jbc.273.37.24095
1977:10.1074/jbc.272.43.27178
1851:10.1074/jbc.274.35.24497
1752:10.1210/endo.142.12.8549
1621:10.1074/jbc.274.50.35553
1048:Chr 16: 11.25 – 11.26 Mb
740:fat cell differentiation
2549:10.1182/blood.V97.1.221
2466:Experimental Hematology
2363:10.1093/emboj/18.5.1309
1702:10.1093/emboj/18.5.1309
1214:Growth hormone receptor
468:vastus lateralis muscle
2662:10.1074/jbc.M010579200
2627:10.1074/jbc.M101878200
2445:10.1006/geno.1999.5937
2319:10.1073/pnas.96.5.2071
2266:10.1093/emboj/18.4.904
1937:10.1006/bbrc.1997.7484
1662:10.1074/jbc.C200444200
1580:10.1074/jbc.M101878200
1530:10.1093/emboj/18.4.904
1411:10.1006/bbrc.1997.7080
1055:Chr 16: 10.6 – 10.6 Mb
650:protein ubiquitination
568:protein kinase binding
444:mesenteric lymph nodes
2583:10.1084/jem.193.2.263
282:16 A1|16 5.81 cM
243:Chromosome 16 (mouse)
141:Chromosome 16 (human)
1481:10.1128/JVI.00007-11
655:regulation of growth
3110:Signal transduction
2310:1999PNAS...96.2071Z
2180:1997Natur.387..921E
2128:1997Natur.387..917S
1793:1997Natur.387..921E
1469:Journal of Virology
604:cytoplasmic vesicle
440:submandibular gland
378:canal of the cervix
2770:, which is in the
885:ENSMUSG00000038037
633:Biological process
587:Cellular component
546:Molecular function
3087:
3086:
3083:
3082:
2838:Cytokine receptor
2225:(37): 24095–101.
2057:10.1002/jnr.10145
1844:(35): 24497–502.
1173:negative feedback
1104:
1103:
1100:
1099:
1073:
1072:
1038:
1037:
1013:
1012:
987:
986:
962:
961:
936:
935:
917:
916:
891:
890:
872:
871:
846:
845:
827:
826:
775:
774:
530:
529:
526:
525:
488:
487:
475:
474:
413:
412:
311:
310:
210:
209:
105:SOCS1 - orthologs
16:(Redirected from
3117:
2899:
2894:Adaptor proteins
2805:
2798:
2791:
2782:
2760:
2750:
2717:
2707:
2674:
2664:
2655:(28): 25889–93.
2639:
2629:
2604:
2594:
2561:
2551:
2526:
2516:
2507:(50): 35553–61.
2491:
2481:
2456:
2427:
2409:
2384:
2374:
2351:The EMBO Journal
2341:
2331:
2321:
2287:
2277:
2254:The EMBO Journal
2244:
2234:
2209:
2191:
2157:
2139:
2122:(6636): 917–21.
2106:
2077:
2059:
2034:
2024:
1990:
1989:
1979:
1970:(43): 27178–82.
1955:
1949:
1948:
1919:
1913:
1912:
1902:
1870:
1864:
1863:
1853:
1829:
1823:
1822:
1804:
1771:
1765:
1764:
1754:
1730:
1724:
1723:
1713:
1690:The EMBO Journal
1681:
1675:
1674:
1664:
1640:
1634:
1633:
1623:
1614:(50): 35553–61.
1599:
1593:
1592:
1582:
1558:
1552:
1551:
1541:
1518:The EMBO Journal
1509:
1503:
1502:
1492:
1460:
1451:
1450:
1443:
1437:
1436:
1429:
1423:
1422:
1393:
1387:
1386:
1376:
1353:The EMBO Journal
1344:
1338:
1337:
1326:
1320:
1319:
1308:
1302:
1292:
1281:
1271:
1169:interferon-gamma
1086:
1085:
1057:
1050:
1033:
1017:
1008:
996:
992:RefSeq (protein)
982:
966:
957:
945:
921:
902:
876:
857:
831:
812:
781:
536:
522:
513:
506:
499:
484:
460:secondary oocyte
424:
422:Top expressed in
417:
362:
360:Top expressed in
355:
334:
317:
307:
294:
283:
268:
261:
255:
244:
232:
216:
206:
193:
182:
167:
160:
154:
143:
129:
113:
107:
58:
51:
30:
21:
3125:
3124:
3120:
3119:
3118:
3116:
3115:
3114:
3090:
3089:
3088:
3079:
3026:
2973:
2940:
2888:
2855:
2832:
2814:
2809:
2778:
2763:
2720:
2690:(6): 2199–208.
2677:
2642:
2620:(25): 22133–9.
2607:
2564:
2529:
2494:
2459:
2430:
2387:
2344:
2290:
2247:
2212:
2174:(6636): 921–4.
2160:
2109:
2080:
2037:
2002:
1998:
1996:Further reading
1993:
1957:
1956:
1952:
1921:
1920:
1916:
1885:(10): 3316–26.
1872:
1871:
1867:
1831:
1830:
1826:
1787:(6636): 921–4.
1773:
1772:
1768:
1745:(12): 5286–93.
1732:
1731:
1727:
1683:
1682:
1678:
1655:(44): 42394–8.
1642:
1641:
1637:
1601:
1600:
1596:
1573:(25): 22133–9.
1560:
1559:
1555:
1511:
1510:
1506:
1475:(14): 6955–62.
1462:
1461:
1454:
1445:
1444:
1440:
1431:
1430:
1426:
1395:
1394:
1390:
1359:(12): 2816–26.
1346:
1345:
1341:
1328:
1327:
1323:
1310:
1309:
1305:
1293:
1284:
1272:
1263:
1259:
1242:
1237:
1185:
1137:
1095:View/Edit Mouse
1090:View/Edit Human
1053:
1046:
1043:Location (UCSC)
1029:
1025:
1004:
978:
974:
953:
866:ENSG00000185338
759:
628:
582:
563:protein binding
518:
508:
507:
480:
471:
466:
462:
458:
454:
450:
446:
442:
438:
434:
420:
409:
404:
400:
396:
392:
388:
384:
380:
376:
372:
358:
302:
289:
281:
271:
270:
269:
262:
242:
219:Gene location (
201:
188:
180:
170:
169:
168:
161:
139:
116:Gene location (
67:
54:
47:
28:
23:
22:
15:
12:
11:
5:
3123:
3121:
3113:
3112:
3107:
3105:Cell signaling
3102:
3092:
3091:
3085:
3084:
3081:
3080:
3078:
3077:
3072:
3067:
3062:
3057:
3052:
3047:
3042:
3036:
3034:
3028:
3027:
3025:
3024:
3019:
3014:
3009:
3004:
2999:
2994:
2989:
2983:
2981:
2975:
2974:
2972:
2971:
2966:
2961:
2956:
2950:
2948:
2942:
2941:
2939:
2938:
2933:
2928:
2923:
2918:
2913:
2907:
2905:
2896:
2890:
2889:
2887:
2886:
2881:
2876:
2871:
2865:
2863:
2857:
2856:
2854:
2853:
2848:
2842:
2840:
2834:
2833:
2831:
2830:
2824:
2822:
2816:
2815:
2810:
2808:
2807:
2800:
2793:
2785:
2762:
2761:
2733:(5): 1921–30.
2718:
2675:
2640:
2605:
2562:
2527:
2492:
2472:(10): 1542–7.
2457:
2428:
2385:
2357:(5): 1309–20.
2342:
2288:
2245:
2210:
2158:
2107:
2078:
2035:
1999:
1997:
1994:
1992:
1991:
1950:
1914:
1865:
1824:
1766:
1725:
1696:(5): 1309–20.
1676:
1635:
1594:
1553:
1504:
1452:
1438:
1424:
1388:
1339:
1321:
1303:
1282:
1260:
1258:
1255:
1254:
1253:
1248:
1241:
1238:
1236:
1235:
1229:
1226:Janus kinase 2
1223:
1217:
1211:
1206:
1200:
1193:
1184:
1181:
1161:erythropoietin
1136:
1133:
1102:
1101:
1098:
1097:
1092:
1082:
1081:
1075:
1074:
1071:
1070:
1068:
1066:
1059:
1058:
1051:
1044:
1040:
1039:
1036:
1035:
1021:
1020:
1014:
1011:
1010:
1000:
999:
993:
989:
988:
985:
984:
970:
969:
963:
960:
959:
949:
948:
942:
938:
937:
934:
933:
925:
924:
918:
915:
914:
906:
905:
899:
893:
892:
889:
888:
880:
879:
873:
870:
869:
861:
860:
854:
848:
847:
844:
843:
835:
834:
828:
825:
824:
816:
815:
809:
803:
802:
797:
792:
788:
787:
777:
776:
773:
772:
761:
760:
758:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
636:
634:
630:
629:
627:
626:
621:
616:
611:
606:
601:
596:
590:
588:
584:
583:
581:
580:
575:
570:
565:
560:
555:
549:
547:
543:
542:
532:
531:
528:
527:
524:
523:
515:
514:
496:
490:
489:
486:
485:
477:
476:
473:
472:
470:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
426:
425:
414:
411:
410:
408:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
364:
363:
351:
350:
342:
331:
325:
324:
321:RNA expression
313:
312:
309:
308:
300:
296:
295:
287:
284:
279:
273:
272:
263:
256:
250:
246:
245:
240:
234:
233:
225:
224:
212:
211:
208:
207:
199:
195:
194:
186:
183:
178:
172:
171:
162:
155:
149:
145:
144:
137:
131:
130:
122:
121:
109:
108:
65:
61:
60:
52:
44:
43:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3122:
3111:
3108:
3106:
3103:
3101:
3098:
3097:
3095:
3076:
3073:
3071:
3068:
3066:
3063:
3061:
3058:
3056:
3053:
3051:
3048:
3046:
3043:
3041:
3038:
3037:
3035:
3033:
3029:
3023:
3020:
3018:
3015:
3013:
3010:
3008:
3005:
3003:
3000:
2998:
2995:
2993:
2990:
2988:
2985:
2984:
2982:
2980:
2976:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2951:
2949:
2947:
2943:
2937:
2934:
2932:
2929:
2927:
2924:
2922:
2919:
2917:
2914:
2912:
2909:
2908:
2906:
2904:
2900:
2897:
2895:
2891:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2866:
2864:
2862:
2858:
2852:
2849:
2847:
2844:
2843:
2841:
2839:
2835:
2829:
2826:
2825:
2823:
2821:
2817:
2813:
2806:
2801:
2799:
2794:
2792:
2787:
2786:
2783:
2779:
2776:
2775:
2773:
2772:public domain
2769:
2758:
2754:
2749:
2744:
2740:
2736:
2732:
2728:
2724:
2719:
2715:
2711:
2706:
2701:
2697:
2693:
2689:
2685:
2681:
2676:
2672:
2668:
2663:
2658:
2654:
2650:
2646:
2641:
2637:
2633:
2628:
2623:
2619:
2615:
2611:
2606:
2602:
2598:
2593:
2588:
2584:
2580:
2576:
2572:
2568:
2563:
2559:
2555:
2550:
2545:
2541:
2537:
2533:
2528:
2524:
2520:
2515:
2510:
2506:
2502:
2498:
2493:
2489:
2485:
2480:
2475:
2471:
2467:
2463:
2458:
2454:
2450:
2446:
2442:
2439:(1): 108–11.
2438:
2434:
2429:
2425:
2421:
2417:
2413:
2408:
2403:
2400:(5): 609–16.
2399:
2395:
2391:
2386:
2382:
2378:
2373:
2368:
2364:
2360:
2356:
2352:
2348:
2343:
2339:
2335:
2330:
2325:
2320:
2315:
2311:
2307:
2304:(5): 2071–6.
2303:
2299:
2295:
2289:
2285:
2281:
2276:
2271:
2267:
2263:
2260:(4): 904–15.
2259:
2255:
2251:
2246:
2242:
2238:
2233:
2228:
2224:
2220:
2216:
2211:
2207:
2203:
2199:
2195:
2190:
2189:10.1038/43213
2185:
2181:
2177:
2173:
2169:
2165:
2159:
2155:
2151:
2147:
2143:
2138:
2137:10.1038/43206
2133:
2129:
2125:
2121:
2117:
2113:
2108:
2104:
2100:
2096:
2092:
2089:(5): 235–41.
2088:
2084:
2079:
2075:
2071:
2067:
2063:
2058:
2053:
2049:
2045:
2041:
2036:
2032:
2028:
2023:
2018:
2015:(5): 378–87.
2014:
2010:
2006:
2001:
2000:
1995:
1987:
1983:
1978:
1973:
1969:
1965:
1961:
1954:
1951:
1946:
1942:
1938:
1934:
1931:(2): 439–46.
1930:
1926:
1918:
1915:
1910:
1906:
1901:
1896:
1892:
1888:
1884:
1880:
1876:
1869:
1866:
1861:
1857:
1852:
1847:
1843:
1839:
1835:
1828:
1825:
1820:
1816:
1812:
1808:
1803:
1802:10.1038/43213
1798:
1794:
1790:
1786:
1782:
1778:
1770:
1767:
1762:
1758:
1753:
1748:
1744:
1740:
1739:Endocrinology
1736:
1729:
1726:
1721:
1717:
1712:
1707:
1703:
1699:
1695:
1691:
1687:
1680:
1677:
1672:
1668:
1663:
1658:
1654:
1650:
1646:
1639:
1636:
1631:
1627:
1622:
1617:
1613:
1609:
1605:
1598:
1595:
1590:
1586:
1581:
1576:
1572:
1568:
1564:
1557:
1554:
1549:
1545:
1540:
1535:
1531:
1527:
1524:(4): 904–15.
1523:
1519:
1515:
1508:
1505:
1500:
1496:
1491:
1486:
1482:
1478:
1474:
1470:
1466:
1459:
1457:
1453:
1448:
1442:
1439:
1434:
1428:
1425:
1420:
1416:
1412:
1408:
1404:
1400:
1392:
1389:
1384:
1380:
1375:
1370:
1366:
1362:
1358:
1354:
1350:
1343:
1340:
1335:
1331:
1325:
1322:
1317:
1313:
1307:
1304:
1300:
1296:
1291:
1289:
1287:
1283:
1279:
1275:
1270:
1268:
1266:
1262:
1256:
1252:
1249:
1247:
1244:
1243:
1239:
1233:
1230:
1227:
1224:
1221:
1218:
1215:
1212:
1210:
1207:
1204:
1201:
1198:
1195:
1194:
1192:
1190:
1182:
1180:
1176:
1174:
1170:
1166:
1162:
1158:
1154:
1150:
1146:
1142:
1134:
1132:
1130:
1126:
1123:
1119:
1116:
1112:
1108:
1096:
1091:
1087:
1083:
1080:
1076:
1069:
1067:
1064:
1060:
1056:
1052:
1049:
1045:
1041:
1034:
1032:
1028:
1022:
1018:
1015:
1009:
1007:
1001:
997:
994:
990:
983:
981:
977:
971:
967:
964:
958:
956:
950:
946:
943:
941:RefSeq (mRNA)
939:
932:
931:
926:
922:
919:
913:
912:
907:
903:
900:
898:
894:
887:
886:
881:
877:
874:
868:
867:
862:
858:
855:
853:
849:
842:
841:
836:
832:
829:
823:
822:
817:
813:
810:
808:
804:
801:
798:
796:
793:
789:
786:
782:
778:
771:
767:
762:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
637:
635:
632:
631:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
600:
597:
595:
592:
591:
589:
586:
585:
579:
576:
574:
571:
569:
566:
564:
561:
559:
556:
554:
551:
550:
548:
545:
544:
541:
540:Gene ontology
537:
533:
521:
516:
512:
505:
500:
497:
495:
491:
483:
478:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
430:
427:
423:
418:
415:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
368:
365:
361:
356:
353:
352:
349:
347:
343:
341:
340:
336:
335:
332:
330:
326:
322:
318:
314:
306:
301:
297:
293:
288:
278:
274:
267:
260:
254:
247:
239:
235:
231:
226:
222:
217:
213:
205:
200:
196:
192:
187:
177:
173:
166:
159:
153:
146:
142:
136:
132:
128:
123:
119:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
2861:Janus kinase
2777:
2765:
2764:
2730:
2726:
2687:
2683:
2652:
2648:
2617:
2613:
2577:(2): 263–9.
2574:
2570:
2542:(1): 221–6.
2539:
2535:
2504:
2500:
2469:
2465:
2436:
2432:
2397:
2393:
2354:
2350:
2301:
2297:
2257:
2253:
2222:
2218:
2171:
2167:
2119:
2115:
2086:
2082:
2050:(4): 423–7.
2047:
2043:
2012:
2008:
1967:
1963:
1953:
1928:
1924:
1917:
1882:
1878:
1868:
1841:
1837:
1827:
1784:
1780:
1769:
1742:
1738:
1728:
1693:
1689:
1679:
1652:
1648:
1638:
1611:
1607:
1597:
1570:
1566:
1556:
1521:
1517:
1507:
1472:
1468:
1441:
1427:
1405:(1): 79–83.
1402:
1398:
1391:
1356:
1352:
1342:
1333:
1324:
1315:
1306:
1186:
1183:Interactions
1177:
1138:
1121:
1114:
1106:
1105:
1027:NP_001258532
1024:
1003:
976:NM_001271603
973:
952:
928:
909:
883:
864:
838:
819:
799:
794:
344:
337:
64:External IDs
614:nucleoplasm
464:bone marrow
436:granulocyte
398:granulocyte
303:10,603,400
290:10,600,104
202:11,256,204
189:11,254,417
42:Identifiers
3094:Categories
2009:Stem Cells
1301:, May 2017
1280:, May 2017
1257:References
406:ectocervix
402:lymph node
348:(ortholog)
85:HomoloGene
1125:orthologs
1031:NP_034026
1006:NP_003736
980:NM_009896
955:NM_003745
785:Orthologs
594:cytoplasm
370:beta cell
93:GeneCards
2828:Cytokine
2757:19342366
2714:17148681
2671:11342531
2636:11297560
2601:11208867
2558:11133764
2523:10585430
2488:10517496
2453:10512686
2433:Genomics
2424:14654250
2416:10490100
2381:10064597
2338:10051596
2284:10022833
2103:12076535
2074:33269663
2066:11835308
2031:11553846
1909:11971965
1860:10455112
1761:11713228
1720:10064597
1671:12228220
1630:10585430
1589:11297560
1548:10022833
1499:21593151
1297:–
1276:–
1240:See also
1189:interact
1149:cytokine
1135:Function
1079:Wikidata
764:Sources:
390:appendix
382:testicle
181:16p13.13
2748:2671279
2705:1762483
2592:2193341
2372:1171221
2306:Bibcode
2275:1171183
2241:9727029
2206:4347361
2198:9202126
2176:Bibcode
2154:4325620
2146:9202125
2124:Bibcode
1986:9341160
1945:9344848
1819:4347361
1811:9202126
1789:Bibcode
1711:1171221
1539:1171183
1490:3126571
1419:9266833
1383:7796808
1299:Ensembl
1278:Ensembl
1163:(EPO),
1129:mammals
1111:protein
897:UniProt
852:Ensembl
791:Species
770:QuickGO
609:nucleus
599:cytosol
323:pattern
81:1354910
49:Aliases
2820:Ligand
2755:
2745:
2712:
2702:
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