242:
219:
116:
141:
493:
248:
147:
1581:
Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, et al. (June 2004). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues".
1734:
Scalabrini D, Fenoglio C, Scarpini E, De Riz M, Comi C, Venturelli E, et al. (October 2007). "Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis".
255:
154:
1662:
Li Y, Aroca-Aguilar JD, Ghosh S, Sánchez-Sánchez F, Escribano J, Coca-Prados M (January 2006). "Interaction of myocilin with the C-terminal region of hevin".
711:
692:
77:
1391:
Schraml P, Shipman R, Stulz P, Ludwig CU (March 1993). "cDNA subtraction library construction using a magnet-assisted subtraction technique (MAST)".
1356:
Sullivan MM, Sage EH (June 2004). "Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family".
1786:
1166:
1148:
1801:
1781:
1186:"Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC"
241:
958:
951:
218:
1426:
1796:
1791:
1135:
1114:
1131:
140:
115:
1110:
57:
254:
153:
247:
146:
1693:"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry"
756:
65:
1505:"Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules"
737:
1050:
1540:"Hevin is down-regulated in many cancers and is a negative regulator of cell growth and proliferation"
1034:
129:
44:
934:
930:
901:
897:
893:
867:
863:
838:
834:
830:
1759:
1607:
89:
926:
905:
859:
826:
1751:
1722:
1679:
1650:
1599:
1569:
1526:
1481:
1463:
1408:
1373:
1338:
1289:
1248:
1225:
Hambrock HO, Nitsche DP, Hansen U, Bruckner P, Paulsson M, Maurer P, Hartmann U (March 2003).
1207:
492:
37:
1619:
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004).
85:
1743:
1712:
1704:
1671:
1640:
1632:
1591:
1559:
1551:
1516:
1471:
1453:
1400:
1365:
1328:
1320:
1279:
1238:
1197:
334:
265:
209:
164:
1266:
Sullivan MM, Barker TH, Funk SE, Karchin A, Seo NS, Höök M, et al. (September 2006).
309:
1717:
1692:
1564:
1539:
1476:
1441:
1333:
1308:
1082:
1645:
1620:
626:
621:
616:
611:
595:
590:
585:
580:
575:
570:
554:
549:
544:
539:
534:
1775:
1538:
Claeskens A, Ongenae N, Neefs JM, Cheyns P, Kaijen P, Cools M, Kutoh E (March 2000).
1404:
1202:
1185:
1038:
521:
1611:
1763:
1046:
327:
106:
69:
1747:
1369:
1324:
93:
1171:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1153:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1030:
1675:
1458:
1442:"Hevin-calcyon interaction promotes synaptic reorganization after brain injury"
410:
1042:
226:
123:
73:
1691:
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006).
1467:
1440:
Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, et al. (March 2021).
1227:"SC1/hevin. An extracellular calcium-modulated protein that binds collagen I"
656:
470:
348:
293:
280:
192:
179:
81:
1755:
1726:
1683:
1654:
1603:
1573:
1555:
1521:
1504:
1485:
1377:
1342:
1293:
1284:
1267:
1252:
1243:
1226:
1530:
1412:
1211:
998:
993:
1087:
982:
801:
782:
1268:"Matricellular hevin regulates decorin production and collagen assembly"
1636:
768:
723:
1708:
1041:. Due to its dynamic extracellular roles, being implicated in cancer
966:
678:
1595:
641:
637:
1069:
1057:
61:
501:
1621:"Functional proteomics mapping of a human signaling pathway"
1358:
1029:), is a secreted protein with high structural similarity to
317:
482:
1664:
919:
886:
852:
819:
1427:"Entrez Gene: SPARCL1 SPARC-like 1 (mast9, hevin)"
1127:
1125:
1123:
1106:
1104:
1102:
264:
163:
16:Protein-coding gene in the species Homo sapiens
1132:GRCm38: Ensembl release 89: ENSMUSG00000029309
8:
1111:GRCh38: Ensembl release 89: ENSG00000152583
652:
517:
305:
204:
101:
1716:
1644:
1563:
1520:
1475:
1457:
1332:
1309:"Matricellular proteins and biomaterials"
1283:
1242:
1201:
48:, MAST 9, MAST9, PIG33, SC1, SPARC like 1
1503:Girard JP, Springer TA (February 1996).
591:collagen-containing extracellular matrix
1184:Girard JP, Springer TA (January 1995).
1098:
622:post-translational protein modification
457:paraventricular nucleus of hypothalamus
1307:Morris AH, Kyriakides TR (July 2014).
18:
269:
230:
225:
168:
127:
122:
7:
1053:. In humans hevin is encoded by the
1509:The Journal of Biological Chemistry
1272:The Journal of Biological Chemistry
1231:The Journal of Biological Chemistry
916:
883:
849:
816:
792:
773:
747:
728:
702:
683:
487:
405:
343:
322:
14:
1037:to create intermediate states of
617:anatomical structure development
491:
449:dorsomedial hypothalamic nucleus
253:
246:
240:
217:
152:
145:
139:
114:
1027:high endothelial venule protein
1446:Cell Death and Differentiation
502:More reference expression data
471:More reference expression data
383:Region I of hippocampus proper
1:
1787:Extracellular matrix proteins
238:
137:
1748:10.1016/j.neulet.2007.08.020
1697:Journal of Proteome Research
1405:10.1016/0168-9525(93)90216-5
1370:10.1016/j.biocel.2004.01.017
1325:10.1016/j.matbio.2014.03.002
1203:10.1016/1074-7613(95)90083-7
550:extracellular matrix binding
1802:EF-hand-containing proteins
1782:Genes on human chromosome 4
581:endoplasmic reticulum lumen
1818:
1676:10.1016/j.bbrc.2005.11.082
1459:10.1038/s41418-021-00772-5
627:synaptic membrane adhesion
1544:British Journal of Cancer
1167:"Mouse PubMed Reference:"
1149:"Human PubMed Reference:"
997:
992:
988:
981:
965:
959:Chr 5: 104.23 – 104.26 Mb
946:
923:
890:
879:
856:
823:
812:
799:
795:
780:
776:
767:
754:
750:
735:
731:
722:
709:
705:
690:
686:
677:
662:
655:
651:
635:
520:
516:
499:
490:
481:
468:
429:medial vestibular nucleus
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1033:. It interacts with the
425:dorsal tegmental nucleus
379:external globus pallidus
952:Chr 4: 87.47 – 87.53 Mb
1797:Cell adhesion proteins
1792:Matricellular proteins
1556:10.1054/bjoc.1999.1051
1522:10.1074/jbc.271.8.4511
1285:10.1074/jbc.M510507200
1244:10.1074/jbc.M212291200
437:ventral tegmental area
421:deep cerebellar nuclei
367:superior frontal gyrus
1051:matricellular protein
1049:, it is considered a
596:glutamatergic synapse
571:extracellular exosome
395:primary visual cortex
359:middle temporal gyrus
1736:Neuroscience Letters
1584:Nature Biotechnology
1035:extracellular matrix
1011:SPARC-like protein 1
586:extracellular region
375:orbitofrontal cortex
271:5 E5|5 50.55 cM
232:Chromosome 5 (mouse)
130:Chromosome 4 (human)
612:signal transduction
576:extracellular space
540:calcium ion binding
94:SPARCL1 - orthologs
1637:10.1101/gr.2334104
1393:Trends in Genetics
757:ENSMUSG00000029309
605:Biological process
564:Cellular component
528:Molecular function
453:lobe of cerebellum
1709:10.1021/pr0502065
1021:), also known as
1008:
1007:
1004:
1003:
977:
976:
942:
941:
913:
912:
875:
874:
846:
845:
808:
807:
789:
788:
763:
762:
744:
743:
718:
717:
699:
698:
647:
646:
535:metal ion binding
512:
511:
508:
507:
477:
476:
464:
463:
433:cerebellar vermis
402:
401:
363:postcentral gyrus
300:
299:
199:
198:
1809:
1767:
1730:
1720:
1687:
1658:
1648:
1615:
1577:
1567:
1534:
1524:
1490:
1489:
1479:
1461:
1452:(9): 2571–2588.
1437:
1431:
1430:
1423:
1417:
1416:
1388:
1382:
1381:
1353:
1347:
1346:
1336:
1304:
1298:
1297:
1287:
1278:(37): 27621–32.
1263:
1257:
1256:
1246:
1222:
1216:
1215:
1205:
1181:
1175:
1174:
1163:
1157:
1156:
1145:
1139:
1129:
1118:
1108:
990:
989:
961:
954:
937:
917:
908:
884:
880:RefSeq (protein)
870:
850:
841:
817:
793:
774:
748:
729:
703:
684:
653:
545:collagen binding
518:
504:
495:
488:
473:
413:
411:Top expressed in
406:
391:Brodmann area 46
371:Brodmann area 23
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1817:
1816:
1812:
1811:
1810:
1808:
1807:
1806:
1772:
1771:
1770:
1733:
1690:
1661:
1625:Genome Research
1618:
1580:
1537:
1502:
1498:
1496:Further reading
1493:
1439:
1438:
1434:
1425:
1424:
1420:
1390:
1389:
1385:
1355:
1354:
1350:
1306:
1305:
1301:
1265:
1264:
1260:
1237:(13): 11351–8.
1224:
1223:
1219:
1183:
1182:
1178:
1165:
1164:
1160:
1147:
1146:
1142:
1130:
1121:
1109:
1100:
1096:
1079:
1066:
999:View/Edit Mouse
994:View/Edit Human
957:
950:
947:Location (UCSC)
933:
929:
925:
904:
900:
896:
892:
866:
862:
858:
837:
833:
829:
825:
738:ENSG00000152583
631:
600:
559:
555:protein binding
500:
469:
460:
455:
451:
447:
443:
441:globus pallidus
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1815:
1813:
1805:
1804:
1799:
1794:
1789:
1784:
1774:
1773:
1769:
1768:
1731:
1703:(6): 2070–80.
1688:
1670:(3): 797–804.
1659:
1631:(7): 1324–32.
1616:
1596:10.1038/nbt969
1578:
1550:(6): 1123–30.
1535:
1499:
1497:
1494:
1492:
1491:
1432:
1418:
1383:
1348:
1313:Matrix Biology
1299:
1258:
1217:
1176:
1158:
1140:
1119:
1097:
1095:
1092:
1091:
1090:
1085:
1083:Thrombospondin
1078:
1075:
1074:
1073:
1065:
1062:
1006:
1005:
1002:
1001:
996:
986:
985:
979:
978:
975:
974:
972:
970:
963:
962:
955:
948:
944:
943:
940:
939:
921:
920:
914:
911:
910:
888:
887:
881:
877:
876:
873:
872:
854:
853:
847:
844:
843:
821:
820:
814:
810:
809:
806:
805:
797:
796:
790:
787:
786:
778:
777:
771:
765:
764:
761:
760:
752:
751:
745:
742:
741:
733:
732:
726:
720:
719:
716:
715:
707:
706:
700:
697:
696:
688:
687:
681:
675:
674:
669:
664:
660:
659:
649:
648:
645:
644:
633:
632:
630:
629:
624:
619:
614:
608:
606:
602:
601:
599:
598:
593:
588:
583:
578:
573:
567:
565:
561:
560:
558:
557:
552:
547:
542:
537:
531:
529:
525:
524:
514:
513:
510:
509:
506:
505:
497:
496:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
445:pontine nuclei
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
387:occipital lobe
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1814:
1803:
1800:
1798:
1795:
1793:
1790:
1788:
1785:
1783:
1780:
1779:
1777:
1765:
1761:
1757:
1753:
1749:
1745:
1741:
1737:
1732:
1728:
1724:
1719:
1714:
1710:
1706:
1702:
1698:
1694:
1689:
1685:
1681:
1677:
1673:
1669:
1665:
1660:
1656:
1652:
1647:
1642:
1638:
1634:
1630:
1626:
1622:
1617:
1613:
1609:
1605:
1601:
1597:
1593:
1590:(6): 724–31.
1589:
1585:
1579:
1575:
1571:
1566:
1561:
1557:
1553:
1549:
1545:
1541:
1536:
1532:
1528:
1523:
1518:
1515:(8): 4511–7.
1514:
1510:
1506:
1501:
1500:
1495:
1487:
1483:
1478:
1473:
1469:
1465:
1460:
1455:
1451:
1447:
1443:
1436:
1433:
1428:
1422:
1419:
1414:
1410:
1406:
1402:
1398:
1394:
1387:
1384:
1379:
1375:
1371:
1367:
1363:
1359:
1352:
1349:
1344:
1340:
1335:
1330:
1326:
1322:
1318:
1314:
1310:
1303:
1300:
1295:
1291:
1286:
1281:
1277:
1273:
1269:
1262:
1259:
1254:
1250:
1245:
1240:
1236:
1232:
1228:
1221:
1218:
1213:
1209:
1204:
1199:
1196:(1): 113–23.
1195:
1191:
1187:
1180:
1177:
1172:
1168:
1162:
1159:
1154:
1150:
1144:
1141:
1137:
1133:
1128:
1126:
1124:
1120:
1116:
1112:
1107:
1105:
1103:
1099:
1093:
1089:
1086:
1084:
1081:
1080:
1076:
1071:
1068:
1067:
1063:
1061:
1059:
1056:
1052:
1048:
1044:
1040:
1039:cell adhesion
1036:
1032:
1028:
1024:
1020:
1016:
1012:
1000:
995:
991:
987:
984:
980:
973:
971:
968:
964:
960:
956:
953:
949:
945:
938:
936:
932:
928:
922:
918:
915:
909:
907:
903:
899:
895:
889:
885:
882:
878:
871:
869:
865:
861:
855:
851:
848:
842:
840:
836:
832:
828:
822:
818:
815:
813:RefSeq (mRNA)
811:
804:
803:
798:
794:
791:
785:
784:
779:
775:
772:
770:
766:
759:
758:
753:
749:
746:
740:
739:
734:
730:
727:
725:
721:
714:
713:
708:
704:
701:
695:
694:
689:
685:
682:
680:
676:
673:
670:
668:
665:
661:
658:
654:
650:
643:
639:
634:
628:
625:
623:
620:
618:
615:
613:
610:
609:
607:
604:
603:
597:
594:
592:
589:
587:
584:
582:
579:
577:
574:
572:
569:
568:
566:
563:
562:
556:
553:
551:
548:
546:
543:
541:
538:
536:
533:
532:
530:
527:
526:
523:
522:Gene ontology
519:
515:
503:
498:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1742:(3): 173–6.
1739:
1735:
1700:
1696:
1667:
1663:
1628:
1624:
1587:
1583:
1547:
1543:
1512:
1508:
1449:
1445:
1435:
1421:
1396:
1392:
1386:
1364:(6): 991–6.
1361:
1357:
1351:
1316:
1312:
1302:
1275:
1271:
1261:
1234:
1230:
1220:
1193:
1189:
1179:
1170:
1161:
1152:
1143:
1064:Interactions
1054:
1047:inflammation
1026:
1022:
1018:
1014:
1010:
1009:
935:NP_001345945
931:NP_001345943
924:
902:NP_001278906
898:NP_001278905
894:NP_001121782
891:
868:NM_001359016
864:NM_001359014
857:
839:NM_001291977
835:NM_001291976
831:NM_001128310
824:
800:
781:
755:
736:
710:
691:
671:
666:
333:
326:
292:104,261,599
279:104,226,977
53:External IDs
1399:(3): 70–1.
1025:(short for
191:87,531,061
178:87,473,335
31:Identifiers
1776:Categories
1319:: 183–91.
1138:, May 2017
1117:, May 2017
1094:References
1043:metastasis
337:(ortholog)
74:HomoloGene
1468:1350-9047
1072:(calcyon)
927:NP_034227
906:NP_004675
860:NM_010097
827:NM_004684
657:Orthologs
82:GeneCards
1756:17825989
1727:16335952
1684:16316624
1655:15231748
1612:36630738
1604:15146195
1574:10735494
1486:33753902
1378:15094114
1343:24657843
1294:16844696
1253:12538579
1190:Immunity
1134:–
1113:–
1088:Tenascin
1077:See also
983:Wikidata
636:Sources:
1764:9381979
1718:1850943
1565:2363342
1531:8626806
1477:8408247
1413:8488563
1334:4167162
1212:7600298
1136:Ensembl
1115:Ensembl
1055:SPARCL1
1015:SPARCL1
769:UniProt
724:Ensembl
663:Species
642:QuickGO
312:pattern
86:SPARCL1
45:SPARCL1
38:Aliases
22:SPARCL1
1762:
1754:
1725:
1715:
1682:
1653:
1646:442148
1643:
1610:
1602:
1572:
1562:
1529:
1484:
1474:
1466:
1411:
1376:
1341:
1331:
1292:
1251:
1210:
969:search
967:PubMed
802:P70663
783:Q14515
679:Entrez
483:BioGPS
170:4q22.1
70:108110
62:606041
1760:S2CID
1608:S2CID
1031:SPARC
1023:hevin
712:13602
672:Mouse
667:Human
638:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
1752:PMID
1723:PMID
1680:PMID
1651:PMID
1600:PMID
1570:PMID
1527:PMID
1482:PMID
1464:ISSN
1409:PMID
1374:PMID
1339:PMID
1290:PMID
1249:PMID
1208:PMID
1070:CALY
1058:gene
1045:and
693:8404
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
78:3438
58:OMIM
1744:doi
1740:425
1713:PMC
1705:doi
1672:doi
1668:339
1641:PMC
1633:doi
1592:doi
1560:PMC
1552:doi
1517:doi
1513:271
1472:PMC
1454:doi
1401:doi
1366:doi
1329:PMC
1321:doi
1280:doi
1276:281
1239:doi
1235:278
1198:doi
1019:SC1
1017:or
288:End
187:End
90:OMA
66:MGI
1778::
1758:.
1750:.
1738:.
1721:.
1711:.
1699:.
1695:.
1678:.
1666:.
1649:.
1639:.
1629:14
1627:.
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1122:^
1101:^
1060:.
640:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
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92::
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