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24:
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and by
Sequella Inc internationally. In July 2012, Infectex received notification from the Russian Ministry of Health for approval to begin the pivotal clinical trial associated with a drug registration submission, and can proceed with the clinical development of SQ109 for treatment of tuberculosis
509:"PRESS RELEASE Maxwell Biotech Venture Fund's Portfolio Company, Infectex, Receives Russian Regulator's Approval to Conduct Pivotal Clinical Trial for Sequella's Antibiotic, SQ109, for Tuberculosis"
298:
347:
SQ109 completed three phase I studies in the U.S. and one Phase II efficacy studies in tuberculosis patients in Africa. SQ109 showed activity against both drug susceptible and
1039:
1143:
95:
1029:
544:
210:
455:
Meng, Q.; Luo, H.; Liu, Y.; Li, W.; Zhang, W.; Yao, Q. (2009). "Synthesis and evaluation of carbamate prodrugs of SQ109 as antituberculosis agents".
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Jia, L.; Tomaszewski, J. E.; Hanrahan, C.; Coward, L.; Noker, P.; Gorman, G.; Nikonenko, B.; Protopopova, M. (2009).
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408:"Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug"
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strains. In preclinical studies SQ109 enhanced the activity of anti-tubercular drugs
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and reduced by >30% the time required to cure mice of experimental TB.
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Except where otherwise noted, data are given for materials in their
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1040:Isoniazid/pyridoxine/sulfamethoxazole/trimethoprim
388:(An older drug with a similar mechanism of action)
320:is a drug undergoing development for treatment of
332:On October 16, 2007, it was given the status of
141:
70:
1137:
538:
491:"New FDA Orphan Drugs: AVI-4658, SQ109, ATIR"
8:
1030:Ethambutol/isoniazid/pyrazinamide/rifampicin
457:Bioorganic & Medicinal Chemistry Letters
366:SQ109 is being developed by OOO Infectex in
340:(FDA) for use against drug-susceptible and
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816:
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218:CC(=CCC/C(=C/CNCCN1C2CC3CC(C2)CC1C3)/C)C
511:. Reuters. 26 July 2012. Archived from
398:
353:extensively drug-resistant tuberculosis
215:
190:
7:
1095:
1093:
132:
1116:. You can help Knowledge (XXG) by
14:
1045:Rifampicin/isoniazid/pyrazinamide
349:multi-drug-resistant tuberculosis
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283:
251:
245:
22:
1035:Ethambutol/isoniazid/rifampicin
412:British Journal of Pharmacology
279:(at 25 °C , 100 kPa).
239:
1:
338:Food and Drug Administration
929:Thioacetazone (amithiozone)
730:Protein synthesis inhibitor
371:in the Russian Federation.
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1092:
469:10.1016/j.bmcl.2009.03.091
1188:Antiinfective agent stubs
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273:
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812:Cell envelope antibiotic
698:Topoisomerase inhibitors
1168:Anti-tuberculosis drugs
790:Polypeptide antibiotics
682:Calcium aminosalicylate
687:Sodium aminosalicylate
575:Nucleic acid inhibitor
558:tuberculosis treatment
424:10.1038/sj.bjp.0705984
857:arabinosyltransferase
677:4-Aminosalicylic acid
495:Medscape Medical News
1025:Ethambutol/isoniazid
351:bacteria, including
37:Preferred IUPAC name
893:synth. inhibition:
515:on 1 February 2013.
497:. 11 November 2007.
269: g·mol
48:-ethane-1,2-diamine
18:
1173:Russian inventions
1080:Never to phase III
562:leprostatic agents
554:Antimycobacterials
306:Infobox references
44:-(Adamantan-2-yl)-
16:
1125:
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927:Others/unsorted:
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314:Chemical compound
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175:CompTox Dashboard
96:Interactive image
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1178:Secondary amines
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234:Chemical formula
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1070:Clinical trials
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844:Arabinogalactan
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739:Aminoglycosides
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463:(10): 2808–10.
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995:Nitroimidazole
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589:RNA polymerase
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942:Other/unknown
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916:Prothionamide
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821:Peptidoglycan
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344:TB bacteria.
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1118:expanding it
1104:
1018:Combinations
1005:
999:
993:
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967:Pyrazinamide
960:
948:
900:Methaniazide
891:mycolic acid
878:Mycolic acid
867:
757:Streptomycin
716:Moxifloxacin
711:Gatifloxacin
675:
556:, including
513:the original
503:
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418:(1): 80–87.
415:
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365:
346:
336:by the U.S.
331:
322:tuberculosis
317:
316:
55:Identifiers
45:
41:
1163:Adamantanes
1066:from market
989:Bedaquiline
955:Clofazimine
921:Thiocarlide
911:Ethionamide
859:inhibitor:
834:Cycloserine
798:Capreomycin
767:Oxazolidone
655:Solasulfone
623:Antifolates
608:Rifapentine
334:Orphan drug
227:Properties
72:502487-67-4
1157:Categories
1007:Pretomanid
983:Terizidone
971:Morinamide
887:Hydrazides
861:Ethambutol
832:analogue:
703:quinolones
640:Acedapsone
598:Rifampicin
584:Rifamycins
393:References
386:Ethambutol
381:Adamantane
328:Background
262:Molar mass
163:9AU7XUV31A
108:IUPHAR/BPS
83:3D model (
62:CAS Number
1076:Phase III
1064:Withdrawn
1001:Delamanid
978:Isoxazole
950:Phenazine
895:Isoniazid
780:Sutezolid
775:Linezolid
752:Kanamycin
660:Sulfoxone
613:Rifalazil
603:Rifabutin
591:inhibitor
357:isoniazid
962:Pyrazine
747:Amikacin
645:Diucifon
477:19362471
442:15644871
375:See also
361:rifampin
830:Alanine
635:Dapsone
433:1575972
299:what is
297: (
267:330.560
143:5274428
130:PubChem
1183:Dienes
1059:WHO-EM
650:Promin
475:
440:
430:
368:Russia
294:verify
291:
211:SMILES
31:Names
17:SQ109
1105:This
880:layer
868:SQ109
846:layer
823:layer
318:SQ109
85:JSmol
1114:stub
1110:drug
560:and
473:PMID
438:PMID
359:and
154:UNII
118:7997
669:ASA
627:DSI
566:J04
465:doi
428:PMC
420:doi
416:144
180:EPA
133:CID
1159::
1072::
1004:,
969:,
909::
493:.
471:.
461:19
459:.
436:.
426:.
414:.
410:.
324:.
249:38
243:22
1145:e
1138:t
1131:v
1120:.
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998:(
985:)
981:(
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965:(
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953:(
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700:/
689:)
680:(
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586:/
568:)
564:(
546:e
539:t
532:v
479:.
467::
444:.
422::
289:Y
255:2
252:N
246:H
240:C
182:)
178:(
87:)
46:N
42:N
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