297:
274:
1371:. This discrepancy indicates that other protein regions in addition contribute to the different sensitivity or activation threshold shown by both isoforms. The “hidden” EF-hand domain does not bind Ca, but it is critical for intramolecular association, folding and stability of the EF-hand and SAM domains. Very recently it has been reported that structurally critical mutations in the canonical EF-hand, ‘‘hidden’’ EF-hand, or SAM domain disrupt Ca sensitivity due to the destabilization of the entire EF-SAM region.
171:
196:
1559:, cells of the immune system and neurons. Moreover, it is involved in tumorigenesis, the development of autoimmune diseases and mechanisms of neuronal damage after transient ischemic conditions. In resting conditions, cultured HEK293 cells overexpressing or cortical neurons lacking STIM2 have increased or decreased resting intracellular Ca levels respectively, supporting the idea that STIM2 is essential for regulation of intracellular basal Ca levels. However, cells are very active
303:
202:
1305:
1366:
using human STIM1 EF–SAM (residue 58–201) or STIM2 EF–SAM (residue 149–292) fragments show that both isoforms bind Ca with similar affinity (STIM2 Kd~0.5 mM; STIM1 Kd~0.2–0.6 mM), which is within the range of values reported for S/ER . However, STIM2 differs from STIM1 in that it is already partially
1349:
Since the EF-hand and SAM (EF-SAM) domains are vital to STIM function and SOCE regulation, they are now discussed in detail. The EF-hand domain is a Ca sensor used by STIM protein to detect changes in Ca concentration inside the S/ER. STIM isoforms become activated when Ca bound to the EF-hand motif
3414:
Scrideli CA, Carlotti CG, Okamoto OK, Andrade VS, Cortez MA, Motta FJ, Lucio-Eterovic AK, Neder L, Rosemberg S, Oba-Shinjo SM, Marie SK, Tone LG (July 2008). "Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by
1473:
together with STIM1, indicating that STIM isoforms are co-expressed in the same cell, at least in the established cell lines. STIM2 protein is widely expressed in tissues, usually present at lower levels than STIM1 except in brain or liver, were STIM2 seems to be the dominant isoform. Stim2
1445:
domains, mediates the binding of STIM1 to TRPC(1, 2,4 and 5) and the STIM1 migration to the plasma membrane. Furthermore, the cationic lysine-rich region is essential for gating of TRPC1. Li et al. further delineated these regions (aas 425-672) as possible STIM1-Orai1 interaction sites.
1340:
domains. The coiled-coil domains mediate interactions between STIM proteins, allowing them to bind each other and form homo and heterodimers (Fig. 1). Finally, further towards the C-terminus, STIM2 contains a proline/histidine-rich motif and a lysine-rich tail of 17 aas (Fig. 1).
50:
2058:
Williams RT, Senior PV, Van
Stekelenburg L, Layton JE, Smith PJ, Dziadek MA (April 2002). "Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation".
1275:
region shows a significant sequence divergence. The domain architecture of both isoforms is highly conserved in vertebrates (Fig. 1). Mouse STIM2 shares a 92% identity with human STIM2 in the aminoacid sequence according to the pairwise alignment generated by
1142:. Although the functional role of STIM2 has been elusive for many years, studies performed in 2009-2010 on murine models suggested that STIM2 participates in processes of the development and functioning of many cell types, including smooth muscle
1539:
cells, reported that STIM2 mediates SOCE via two store-dependent and store independent modes. Taking together, these results indicate a complex interaction finely regulated by the STIM1: STIM2: Orai cellular ratio and their endogenous levels.
1606:
lymphocytes, which presumably are important in early phases of autoimmune diseases. In fact, STIM2-deficient mice showed mild symptomatology in the early phase of autoimmune diseases. In neuronal tissue, STIM2 plays a crucial role in
1367:
active at basal S/ER and becomes fully activated earlier during S/ER store depletion. Despite the same Ca affinity shown by STIM EF-SAM fragments, the full STIM2 protein showed a lower sensitivity than STIM1 in transfected cells
1324:, a “hidden” EF-hand Ca-binding motif discovered recently and a sterile a-motif (SAM) domain, a well-known protein–protein interaction motif (Fig. 1). The N-terminal portion is separated from the C-terminal region by a single-pass
1379:
Besides the N-terminus, the C-terminal region is also an essential part of STIM proteins. It shows a significant sequence divergence between both isoforms and in STIM1, the C-terminal region is essential for the interaction with
2250:
Grosse J, Braun A, Varga-Szabo D, Beyersdorf N, Schneider B, Zeitlmann L, Hanke P, Schropp P, Mühlstedt S, Zorn C, Huber M, Schmittwolf C, Jagla W, Yu P, Kerkau T, Schulze H, Nehls M, Nieswandt B (November 2007).
1440:
co-expression of different human STIM1 mutants that lack the different C-terminal regions in HEK293 cells, three recent works reported that the ERM domain in the C-terminus (aas 251-535, Fig. 1), containing the
1650:, where both proteins have increased expression and/or increased copy number. Additionally, STIM2 is located in chromosome 4p15.1, a region implicated in invasive carcinomas of the lung, breast, neck and head.
3509:
Pershouse MA, Ligon AH, Pereira-Smith OM, Killary AM, Yung WK, Steck PA (November 1997). "Suppression of transformed phenotype and tumorigenicity after transfer of chromosome 4 into U251 human glioma cells".
2855:"Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components"
1400:-rich region (SPSAPPGGSPHLDSSRSHSPSSPDPDTPSP) in STIM1. The significant divergence in these regions could indicate a divergence in function of STIM isoforms. Unlike STIM1, STIM2 has a dilysine
1358:–mediated depletion. It has been reported that STIM EF-hand mutants that are not able to bind Ca are constitutively active and continually activate SOCE independently of S/ER , in vitro and
1420:
with high or low affinity in presence or absence of Ca, respectively. Most of studies on interactions of the C-terminal region have been performed with the STIM1 isoform. The addition of
1619:
effect of STIM2-deficiency after an ischemic episode indicates that inhibitors of STIM2 function may thus have a potential therapeutic value as neuroprotective agents to treat
310:
209:
2461:
Zheng L, Stathopulos PB, Li GY, Ikura M (April 2008). "Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2".
2818:
Bauer MC, O'Connell D, Cahill DJ, Linse S (June 2008). "Calmodulin binding to the polybasic C-termini of STIM proteins involved in store-operated calcium entry".
2498:"Stored Ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region: An initiation mechanism for capacitive Ca2+ entry"
2020:
Parry DA, Fraser RD, Squire JM (September 2008). "Fifty years of coiled-coils and alpha-helical bundles: a close relationship between sequence and structure".
2723:
Huang GN, Zeng W, Kim JY, Yuan JP, Han L, Muallem S, Worley PF (September 2006). "STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels".
1789:
Williams RT, Manji SS, Parker NJ, Hancock MS, Van
Stekelenburg L, Eid JP, Senior PV, Kazenwadel JS, Shandala T, Saint R, Smith PJ, Dziadek MA (August 2001).
1122:
and S/ER Ca concentration . STIM2 detects small decreases in Ca content stored in the S/ER, switches to the activated state and interacts with so called
767:
1362:. The SAM domain is important for STIM oligomerization, since mutants in this domain lack the ability to form inducible punctae. Ca-binding experiments
748:
132:
3113:
Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA, Wagner SL, Cahalan MD, Veliçelebi G, Stauderman KA (May 2005).
3375:"Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation"
1114:
is considered the mechanism of store refilling and an essential mechanism of Ca signaling in non-electrically excitable cells. While STIM1 triggers
3460:"Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH microarray profiling"
2853:
Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Gill D, Ambudkar IS (March 2007).
1515:. suggested that STIM2 inhibits SOCE when expressed alone, but coexpressed with Orai1 causes substantial constitutive SOCE. In contrast, Brandman
1791:"Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins"
1091:) into the cell. Alternative translation initiation from an AUG and a non-AUG (UUG) start site results in the production of two different STIM2
1758:
1682:. The expression of STIM2 has been shown to be influenced or regulated by presenilins in mouse embryonic fibroblasts and human B lymphocytes.
1428:
pump inhibitor that stimulates SOCE by passive depletion of intracellular Ca stores) to human salivary gland cells as well as dispersed mouse
1740:
1555:. results and suggested that STIM2 participates in processes of the development and functioning of many cell types, including smooth muscle
3738:
1567:
role of STIM2 in intracellular Ca levels would be necessary. In cultured human myoblast, STIM2 participate in cell differentiation into
296:
1229:) have a conserved genomic organization. The D-STIM protein of 570 aas exhibits equal similarity to both STIM1 (33% identical; 50% of
3523:
3373:
Schuhmann MK, Stegner D, Berna-Erro A, Bittner S, Braun A, Kleinschnitz C, Stoll G, Wiendl H, Meuth SG, Nieswandt B (February 2010).
3020:
Berna-Erro A, Braun A, Kraft R, Kleinschnitz C, Schuhmann MK, Stegner D, Wultsch T, Eilers J, Meuth SG, Stoll G, Nieswandt B (2009).
2302:"Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1"
1075:
This gene is a member of the stromal interaction molecule (STIM) family which comprises only two members together with its homologue
999:
3321:"Human muscle economy myoblast differentiation and excitation-contraction coupling use the same molecular partners, STIM1 and STIM2"
1006:
273:
1838:
2402:
Baba Y, Hayashi K, Fujii Y, Mizushima A, Watarai H, Wakamori M, Numaga T, Mori Y, Iino M, Hikida M, Kurosaki T (November 2006).
3694:"Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease"
1727:
1706:
1412:-rich tails of 14 and 17 residues in STIM1 and STIM2 respectively are located at the very end of the C-terminal region. Linear
1351:
3571:
3554:
2404:"Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum"
1139:
1115:
1111:
1103:
3458:
Ruano Y, Mollejo M, Ribalta T, Fiaño C, Camacho FI, Gómez E, de Lope AR, Hernández-Moneo JL, Martínez P, Meléndez B (2006).
1723:
195:
170:
47:
2353:"Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity"
1702:
3553:
Richard F, Pacyna-Gengelbach M, Schlüns K, Fleige B, Winzer KJ, Szymas J, Dietel M, Petersen I, Schwendel A (May 2000).
1332:
structures. A large proportion close to the transmembrane domain comprises a region similar to an ezrin/radixin/moesin (
1080:
112:
1263:
STIM2 protein is a type I transmembrane protein located in the S/ER. Human STIM2 consists of 833 amino acid residues (
309:
208:
302:
201:
3596:"Chromosomal alterations in the clonal evolution to the metastatic stage of squamous cell carcinomas of the lung"
3066:"Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance"
2578:"Dynamics of [Ca2+] in the endoplasmic reticulum and cytoplasm of intact HeLa cells. A comparative study"
3692:
Bojarski L, Pomorski P, Szybinska A, Drab M, Skibinska-Kijek A, Gruszczynska-Biegala J, Kuznicki J (June 2009).
1457:
cells revealed that also STIM2 can physically interact with Orai1, probably though the STIM2 C-terminal region.
812:
120:
3645:"A conserved, lipid-mediated sorting mechanism of yeast Ist2 and mammalian STIM proteins to the peripheral ER"
3164:"STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane"
1271:
regions share 66% similarity over 577 aas (85% of the amino acid sequence of STIM1). Only the extreme of the
2962:
Parvez S, Beck A, Peinelt C, Soboloff J, Lis A, Monteilh-Zoller M, Gill DL, Fleig A, Penner R (March 2008).
1647:
1218:
793:
1615:
reduced the neuronal damage produced by ischemia after transient interruption of blood flow in brain. This
3064:
Oh-Hora M, Yamashita M, Hogan PG, Sharma S, Lamperti E, Chung W, Prakriya M, Feske S, Rao A (April 2008).
1474:
transcription is also dynamically regulated, for instance being upregulated upon differentiation of naive
2351:
Zhang SL, Yeromin AV, Zhang XH, Yu Y, Safrina O, Penna A, Roos J, Stauderman KA, Cahalan MD (June 2006).
2964:"STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation"
2539:"Measurements of the free luminal ER Ca(2+) concentration with targeted "cameleon" fluorescent proteins"
1501:
1416:
from C-terminal polybasic region of human STIM1 (residues 667-685) and STIM2 (residues 730-746) bind to
1405:
1401:
1277:
1088:
1084:
3162:
Zhang SL, Yu Y, Roos J, Kozak JA, Deerinck TJ, Ellisman MH, Stauderman KA, Cahalan MD (October 2005).
3022:"STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death"
2157:"Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation"
2099:
Soboloff J, Spassova MA, Hewavitharana T, He LP, Xu W, Johnstone LS, Dziadek MA, Gill DL (July 2006).
1563:
and intracellular Ca levels are continuously fluctuating. The development of new methods to study the
3232:
3175:
2768:"Di-arginine signals and the K-rich domain retain the Ca²⁺ sensor STIM1 in the endoplasmic reticulum"
2624:"STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels"
2415:
1679:
1325:
1196:
located on the human chromosome 4p15.1, and on the large arm of the mouse chromosome 5, close to the
184:
99:
2673:"Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry"
1450:
1433:
1429:
978:
974:
949:
945:
919:
911:
890:
886:
3674:
3535:
3440:
2797:
2748:
2702:
2130:
1953:
1333:
1233:
sequence conserved) and STIM2 (31% identical; 46% of amino acid sequence conserved). Unicellular
1159:
1106:. Many cellular processes and signaling pathways are started by previous release of Ca stored in
1099:
144:
982:
953:
915:
882:
2906:"STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels"
1328:
that is highly conserved in all STIM proteins. The C-terminal region contains a high degree of
1118:, research on STIM2 function suggests a major role as feedback regulator that stabilizes basal
3715:
3666:
3625:
3576:
3527:
3491:
3432:
3396:
3352:
3301:
3260:
3201:
3144:
3095:
3043:
2995:
2935:
2886:
2835:
2789:
2740:
2694:
2653:
2599:
2558:
2519:
2478:
2443:
2384:
2333:
2282:
2232:
2178:
2122:
2076:
2037:
2002:
1945:
1910:
1875:
1820:
1624:
92:
40:
3705:
3656:
3615:
3607:
3566:
3519:
3481:
3471:
3424:
3386:
3342:
3332:
3291:
3250:
3240:
3191:
3183:
3134:
3126:
3085:
3077:
3033:
2985:
2975:
2925:
2917:
2876:
2866:
2827:
2779:
2732:
2684:
2643:
2635:
2589:
2550:
2538:
2509:
2470:
2433:
2423:
2374:
2364:
2323:
2313:
2272:
2264:
2222:
2214:
2168:
2112:
2068:
2029:
1992:
1984:
1937:
1902:
1865:
1810:
1802:
1600:
1580:
1244:
389:
320:
264:
219:
1893:
Kim CA, Bowie JU (December 2003). "SAM domains: uniform structure, diversity of function".
140:
1616:
1313:
1293:
1284:
structure is also highly conserved (Fig. 1). Human STIM2 is post-translationally modified
1127:
1092:
364:
1511:. reported a slight reduction in SOCE also by knockdown of STIM2 in HeLa cells. Soboloff
3236:
3179:
2419:
2253:"An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice"
1646:
Finally, an oncogenic function has been demonstrated for STIM2, together with STIM1, in
3620:
3595:
3594:
Petersen S, Aninat-Meyer M, Schlüns K, Gellert K, Dietel M, Petersen I (January 2000).
3486:
3459:
3347:
3320:
3255:
3220:
3196:
3163:
3139:
3114:
3090:
3065:
2990:
2963:
2930:
2905:
2881:
2854:
2648:
2623:
2438:
2403:
2379:
2352:
2328:
2301:
2300:
Mercer JC, Dehaven WI, Smyth JT, Wedel B, Boyles RR, Bird GS, Putney JW (August 2006).
2277:
2252:
2227:
2202:
1997:
1972:
1815:
1790:
1636:
1620:
1612:
1608:
1504:
1321:
1281:
1155:
1102:(Ca) sensors which participate in a mechanism of Ca entry into the cell referred to as
3221:"STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels"
2554:
2072:
1404:
retention signal (K(X)KXX) at its extreme C-terminus which retains the protein in the
682:
677:
672:
667:
662:
657:
652:
636:
631:
626:
621:
616:
600:
595:
590:
585:
580:
3732:
3661:
3644:
3115:"STIM1, an essential and conserved component of store-operated Ca2+ channel function"
2784:
2767:
1576:
1486:
1479:
1289:
1147:
567:
3678:
3539:
3444:
2801:
2752:
2706:
2134:
1957:
124:
1663:
1592:
1532:
1470:
1421:
1381:
1123:
382:
161:
1255:. No additional STIM-like proteins have been identified until now in vertebrates.
3710:
3693:
1469:
is expressed by most human tissues. The STIM2 protein is expressed by many human
148:
2203:"STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx"
2061:
Biochimica et
Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
1806:
1763:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1745:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1632:
1628:
1442:
1337:
1329:
1304:
1288:, such as maturation by cleavage of N-terminal S/ER signaling peptide (14 aas),
3643:
Ercan E, Momburg F, Engel U, Temmerman K, Nickel W, Seedorf M (December 2009).
3319:
Darbellay B, Arnaudeau S, Ceroni D, Bader CR, Konig S, Bernheim L (July 2010).
3225:
Proceedings of the
National Academy of Sciences of the United States of America
2689:
2672:
2639:
2474:
2408:
Proceedings of the
National Academy of Sciences of the United States of America
2357:
Proceedings of the
National Academy of Sciences of the United States of America
1906:
1350:
is released as a result of a decrease in Ca levels inside the S/ER store after
465:
3428:
3278:
Soboloff J, Spassova MA, Tang XD, Hewavitharana T, Xu W, Gill DL (July 2006).
3038:
3021:
2218:
2117:
2100:
2033:
1675:
1631:. Moreover, the same scientific study suggested an important role of STIM2 in
1568:
1417:
1272:
1268:
1264:
1252:
1230:
1205:
1197:
1184:
gene, representing the second member of a two-gene family in vertebrates. The
1107:
281:
178:
128:
3391:
3374:
2594:
2577:
2201:
Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE, Meyer T (July 2005).
3337:
3245:
2428:
2369:
1941:
1870:
1853:
1556:
1389:
1267:) (105-115 kDa) (Fig. 1), 148 additional aas compared to human STIM1. Their
1234:
1204:
family most probably have evolved from a single gene in lower multicellular
1143:
712:
525:
403:
348:
335:
247:
234:
136:
3719:
3670:
3629:
3611:
3580:
3495:
3476:
3436:
3400:
3356:
3305:
3296:
3279:
3264:
3205:
3148:
3099:
3047:
2999:
2939:
2890:
2871:
2839:
2793:
2744:
2698:
2657:
2562:
2523:
2514:
2497:
2482:
2447:
2388:
2337:
2318:
2286:
2236:
2182:
2173:
2156:
2126:
2080:
2041:
1988:
1949:
1914:
1879:
1824:
3531:
3130:
2980:
2603:
2006:
1973:"SAM as a protein interaction domain involved in developmental regulation"
1046:
1041:
1536:
1454:
1413:
1239:
1163:
1030:
857:
838:
3524:
10.1002/(SICI)1098-2264(199711)20:3<260::AID-GCC6>3.0.CO;2-0
3219:
Spassova MA, Soboloff J, He LP, Xu W, Dziadek MA, Gill DL (March 2006).
3187:
1507:
of STIM1, but not STIM2, strongly reduced SOCE in mammalian cells. Liou
1453:
experiments after transient coexpression of STIM2 and Orai1 proteins in
1640:
1596:
1520:
1475:
1397:
1385:
1317:
1151:
1119:
1062:
824:
779:
2831:
1519:. suggested that STIM2 could act as a regulator that stabilizes basal
1500:
The STIM2 function has been controversial. Initial studies found that
69:
3572:
10.1002/1097-0215(20000520)89:3<305::AID-IJC15>3.0.CO;2-8
3280:"Orai1 and STIM reconstitute store-operated calcium channel function"
2268:
1572:
1409:
1393:
1392:-rich motif (PHAPHPSHPRHPHHPQHTPHSLPSPDP) at a similar position to a
1193:
1014:
734:
2921:
2736:
2496:
Stathopulos PB, Li GY, Plevin MJ, Ames JB, Ikura M (November 2006).
3081:
2671:
Stathopulos PB, Zheng L, Li GY, Plevin MJ, Ikura M (October 2008).
2101:"STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry"
1667:
1659:
1425:
1180:
1131:
1076:
697:
693:
1671:
1588:
1466:
1189:
1135:
1098:
Both members of the STIM family were identified in 2005 as free-
1069:
116:
1854:"Unicellular Ca2+ signaling 'toolkit' at the origin of metazoa"
3555:"Patterns of chromosomal imbalances in invasive breast cancer"
3698:
Biochimica et
Biophysica Acta (BBA) - Molecular Cell Research
2904:
Yuan JP, Zeng W, Huang GN, Worley PF, Muallem S (June 2007).
1408:, whereas STIM1 can travel to cell surface. Finally, similar
1079:, and likely arose from a common ancestral gene. They encode
3415:
oligonucleotide microarray and real-time quantitative PCR".
1658:
As mentioned before, STIM2 has been shown to interact with
1296:, but the phosphorylated sites are still unknown (Fig. 1).
1971:
Schultz J, Ponting CP, Hofmann K, Bork P (January 1997).
372:
1247:
has been reported to have a STIM-like gene, however no
2766:
Ercan E, Chung SH, Bhardwaj R, Seedorf M (July 2012).
2622:
Brandman O, Liou J, Park WS, Meyer T (December 2007).
2155:
Li Z, Lu J, Xu P, Xie X, Chen L, Xu T (October 2007).
1928:
Qiao F, Bowie JU (May 2005). "The many faces of SAM".
1312:
The N-terminal region of STIM2 is located in the S/ER
1083:
that are located in the sarco/endoplasmic reticulum (
658:
activation of store-operated calcium channel activity
537:
1531:
transient coexpression of human STIM2 and different
2463:
1839:"Entrez Gene: STIM2 stromal interaction molecule 2"
1208:into two related genes in vertebrates, since human
967:
938:
904:
875:
480:
dentate gyrus of hippocampal formation granule cell
3015:
3013:
3011:
3009:
1719:
1717:
1715:
1698:
1696:
1694:
1162:and mechanisms of neuronal damage after transient
3368:
3366:
2576:Barrero MJ, Montero M, Alvarez J (October 1997).
319:
218:
2617:
2615:
2613:
2094:
2092:
2090:
2053:
2051:
3059:
3057:
1784:
1782:
1780:
1778:
1776:
1774:
1772:
1178:was identified as a new human homologue of the
16:Protein-coding gene in the species Homo sapiens
2957:
2955:
2953:
2951:
2949:
1724:GRCm38: Ensembl release 89: ENSMUSG00000039156
1571:. In the immune system, STIM2 participates in
2813:
2811:
2718:
2716:
8:
2196:
2194:
2192:
668:positive regulation of calcium ion transport
1703:GRCh38: Ensembl release 89: ENSG00000109689
1543:Studies performed in 2009-2010 using human
2150:
2148:
2146:
2144:
708:
563:
360:
259:
156:
58:
3709:
3660:
3619:
3570:
3485:
3475:
3390:
3346:
3336:
3295:
3254:
3244:
3195:
3138:
3089:
3037:
2989:
2979:
2929:
2880:
2870:
2783:
2688:
2647:
2593:
2513:
2437:
2427:
2378:
2368:
2327:
2317:
2276:
2226:
2172:
2116:
1996:
1869:
1814:
1595:, as well as in differentiation of naive
1110:, which needs of a continuous refilling.
1303:
1690:
586:store-operated calcium channel activity
1059:Stromal interaction molecule 2 (STIM2)
18:
2537:Demaurex N, Frieden M (August 2003).
2257:The Journal of Clinical Investigation
324:
285:
280:
223:
182:
177:
7:
1251:-like genes have been identified in
476:vestibular membrane of cochlear duct
3325:The Journal of Biological Chemistry
3284:The Journal of Biological Chemistry
2859:The Journal of Biological Chemistry
2582:The Journal of Biological Chemistry
2502:The Journal of Biological Chemistry
2306:The Journal of Biological Chemistry
2161:The Journal of Biological Chemistry
678:calcium ion transmembrane transport
1461:Expression and tissue distribution
1436:of TRPC1 and Orai1 with STIM1. By
964:
935:
901:
872:
848:
829:
803:
784:
758:
739:
601:calcium channel regulator activity
542:
460:
398:
377:
14:
1575:activation-induced production of
1384:channels. Human STIM2 contains a
1065:that in humans is encoded by the
3662:10.1111/j.1600-0854.2009.00995.x
2785:10.1111/j.1600-0854.2012.01359.x
1609:ischemia-induced neuronal damage
1124:store-operated Ca (SOC) channels
683:cellular calcium ion homeostasis
308:
301:
295:
272:
207:
200:
194:
169:
103:, stromal interaction molecule 2
3559:International Journal of Cancer
3512:Genes, Chromosomes & Cancer
1858:Molecular Biology and Evolution
1587:, probably by stabilization of
1895:Trends in Biochemical Sciences
1611:, and the absence of STIM2 in
1104:store-operated Ca entry (SOCE)
627:endoplasmic reticulum membrane
617:integral component of membrane
526:More reference expression data
414:olfactory zone of nasal mucosa
1:
2555:10.1016/S0143-4160(03)00081-2
2073:10.1016/S0167-4838(02)00211-X
2022:Journal of Structural Biology
1643:transmission and plasticity.
1081:type 1 transmembrane proteins
496:vestibular sensory epithelium
293:
192:
3711:10.1016/j.bbamcr.2008.11.008
673:store-operated calcium entry
484:Epithelium of choroid plexus
3739:Genes on human chromosome 4
3119:The Journal of Cell Biology
1625:neurodegenerative disorders
1336:) domain that contains two
446:right lobe of thyroid gland
3755:
2690:10.1016/j.cell.2008.08.006
2640:10.1016/j.cell.2007.11.039
2475:10.1016/j.bbrc.2007.12.129
1907:10.1016/j.tibs.2003.11.001
1551:models confirmed Brandman
3600:British Journal of Cancer
3429:10.1007/s11060-008-9579-4
3417:Journal of Neuro-Oncology
3039:10.1126/scisignal.2000522
2219:10.1016/j.cub.2005.05.055
2118:10.1016/j.cub.2006.05.051
2034:10.1016/j.jsb.2008.01.016
1807:10.1042/0264-6021:3570673
1759:"Mouse PubMed Reference:"
1741:"Human PubMed Reference:"
1678:and also plasma membrane
1523:and ER Ca levels. Parvez
1316:and contains a canonical
1045:
1040:
1036:
1029:
1013:
994:
971:
942:
931:
908:
879:
868:
855:
851:
836:
832:
823:
810:
806:
791:
787:
778:
765:
761:
746:
742:
733:
718:
711:
707:
691:
566:
562:
550:
545:
536:
523:
472:
463:
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
3392:10.4049/jimmunol.0902161
2595:10.1074/jbc.272.44.27694
1292:and variable degrees of
3338:10.1074/jbc.M110.118984
3246:10.1073/pnas.0510050103
2429:10.1073/pnas.0608358103
2370:10.1073/pnas.0603161103
1942:10.1126/stke.2862005re7
1795:The Biochemical Journal
1648:glioblastoma multiforme
1219:Drosophila melanogaster
1007:Chr 5: 54.16 – 54.28 Mb
1000:Chr 4: 26.86 – 27.03 Mb
3612:10.1054/bjoc.1999.0878
3477:10.1186/1476-4598-5-39
3297:10.1074/jbc.C600126200
2872:10.1074/jbc.M608942200
2515:10.1074/jbc.M608247200
2319:10.1074/jbc.M604589200
2174:10.1074/jbc.M703573200
1989:10.1002/pro.5560060128
1309:
1108:subcellular organelles
3379:Journal of Immunology
3131:10.1083/jcb.200502019
2981:10.1096/fj.07-9449com
1871:10.1093/molbev/msn077
1627:involving altered Ca
1581:interferon gamma (IFN
1451:coimmunoprecipitation
1434:coimmunoprecipitation
1308:Figure 1. STIM family
1307:
1158:, the development of
1154:, and is involved in
663:calcium ion transport
632:endoplasmic reticulum
504:epithelium of stomach
1240:Monosiga brevicollis
326:5 C1|5 29.69 cM
287:Chromosome 5 (mouse)
185:Chromosome 4 (human)
62:List of PDB id codes
35:Available structures
3237:2006PNAS..103.4040S
3188:10.1038/nature04147
3180:2005Natur.437..902Z
2910:Nature Cell Biology
2725:Nature Cell Biology
2420:2006PNAS..10316704B
1852:Cai X (July 2008).
1577:interleukin2 (IL-2)
1430:submandibular gland
1326:transmembrane motif
1300:Domain architecture
1160:autoimmune diseases
1138:channels, allowing
581:calcium ion binding
1345:EF-hand-SAM region
1310:
813:ENSMUSG00000039156
646:Biological process
610:Cellular component
574:Molecular function
488:hippocampus proper
422:right uterine tube
418:anterior pituitary
3070:Nature Immunology
3026:Science Signaling
2832:10.1021/bi800496a
1680:phosphoinositides
1666:channels such as
1591:residence in the
1375:C-terminal region
1259:Protein structure
1200:. The members of
1188:gene contains 12
1056:
1055:
1052:
1051:
1025:
1024:
990:
989:
961:
960:
927:
926:
898:
897:
864:
863:
845:
844:
819:
818:
800:
799:
774:
773:
755:
754:
703:
702:
596:metal ion binding
558:
557:
554:
553:
532:
531:
519:
518:
457:
456:
355:
354:
254:
253:
149:STIM2 - orthologs
81:
80:
77:
76:
45:Ortholog search:
3746:
3724:
3723:
3713:
3689:
3683:
3682:
3664:
3640:
3634:
3633:
3623:
3591:
3585:
3584:
3574:
3550:
3544:
3543:
3506:
3500:
3499:
3489:
3479:
3464:Molecular Cancer
3455:
3449:
3448:
3411:
3405:
3404:
3394:
3370:
3361:
3360:
3350:
3340:
3331:(29): 22437–47.
3316:
3310:
3309:
3299:
3275:
3269:
3268:
3258:
3248:
3216:
3210:
3209:
3199:
3159:
3153:
3152:
3142:
3110:
3104:
3103:
3093:
3061:
3052:
3051:
3041:
3017:
3004:
3003:
2993:
2983:
2959:
2944:
2943:
2933:
2901:
2895:
2894:
2884:
2874:
2850:
2844:
2843:
2815:
2806:
2805:
2787:
2763:
2757:
2756:
2720:
2711:
2710:
2692:
2668:
2662:
2661:
2651:
2619:
2608:
2607:
2597:
2573:
2567:
2566:
2534:
2528:
2527:
2517:
2508:(47): 35855–62.
2493:
2487:
2486:
2458:
2452:
2451:
2441:
2431:
2399:
2393:
2392:
2382:
2372:
2348:
2342:
2341:
2331:
2321:
2312:(34): 24979–90.
2297:
2291:
2290:
2280:
2269:10.1172/JCI32312
2247:
2241:
2240:
2230:
2198:
2187:
2186:
2176:
2167:(40): 29448–56.
2152:
2139:
2138:
2120:
2096:
2085:
2084:
2055:
2046:
2045:
2017:
2011:
2010:
2000:
1968:
1962:
1961:
1925:
1919:
1918:
1890:
1884:
1883:
1873:
1849:
1843:
1842:
1835:
1829:
1828:
1818:
1801:(Pt 3): 673–85.
1786:
1767:
1766:
1755:
1749:
1748:
1737:
1731:
1721:
1710:
1700:
1676:calmodulin (CaM)
1245:choanoflagellate
1243:, a unicellular
1038:
1037:
1009:
1002:
985:
965:
956:
936:
932:RefSeq (protein)
922:
902:
893:
873:
849:
830:
804:
785:
759:
740:
709:
564:
543:
528:
468:
466:Top expressed in
461:
438:nasal epithelium
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
3754:
3753:
3749:
3748:
3747:
3745:
3744:
3743:
3729:
3728:
3727:
3691:
3690:
3686:
3655:(12): 1802–18.
3642:
3641:
3637:
3593:
3592:
3588:
3552:
3551:
3547:
3508:
3507:
3503:
3457:
3456:
3452:
3413:
3412:
3408:
3372:
3371:
3364:
3318:
3317:
3313:
3290:(30): 20661–5.
3277:
3276:
3272:
3218:
3217:
3213:
3174:(7060): 902–5.
3161:
3160:
3156:
3112:
3111:
3107:
3063:
3062:
3055:
3019:
3018:
3007:
2961:
2960:
2947:
2922:10.1038/ncb1590
2903:
2902:
2898:
2865:(12): 9105–16.
2852:
2851:
2847:
2826:(23): 6089–91.
2817:
2816:
2809:
2778:(7): 992–1003.
2765:
2764:
2760:
2737:10.1038/ncb1454
2722:
2721:
2714:
2670:
2669:
2665:
2621:
2620:
2611:
2588:(44): 27694–9.
2575:
2574:
2570:
2536:
2535:
2531:
2495:
2494:
2490:
2460:
2459:
2455:
2414:(45): 16704–9.
2401:
2400:
2396:
2363:(24): 9357–62.
2350:
2349:
2345:
2299:
2298:
2294:
2263:(11): 3540–50.
2249:
2248:
2244:
2213:(13): 1235–41.
2207:Current Biology
2200:
2199:
2190:
2154:
2153:
2142:
2111:(14): 1465–70.
2105:Current Biology
2098:
2097:
2088:
2057:
2056:
2049:
2019:
2018:
2014:
1977:Protein Science
1970:
1969:
1965:
1927:
1926:
1922:
1892:
1891:
1887:
1851:
1850:
1846:
1837:
1836:
1832:
1788:
1787:
1770:
1757:
1756:
1752:
1739:
1738:
1734:
1722:
1713:
1701:
1692:
1688:
1656:
1621:ischemic injury
1617:neuroprotective
1604:
1584:
1498:
1490:
1483:
1463:
1432:cells increase
1377:
1355:
1347:
1302:
1294:phosphorylation
1261:
1172:
1146:, cells of the
1128:plasma membrane
1126:located in the
1047:View/Edit Mouse
1042:View/Edit Human
1005:
998:
995:Location (UCSC)
981:
977:
973:
952:
948:
944:
918:
914:
910:
889:
885:
881:
794:ENSG00000109689
687:
641:
622:plasma membrane
605:
591:protein binding
524:
515:
510:
506:
502:
498:
494:
490:
486:
482:
478:
464:
453:
448:
444:
440:
436:
432:
428:
424:
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
3752:
3750:
3742:
3741:
3731:
3730:
3726:
3725:
3684:
3635:
3586:
3545:
3501:
3450:
3406:
3385:(3): 1536–42.
3362:
3311:
3270:
3231:(11): 4040–5.
3211:
3154:
3105:
3082:10.1038/ni1574
3053:
3005:
2945:
2896:
2845:
2807:
2758:
2731:(9): 1003–10.
2712:
2663:
2634:(7): 1327–39.
2609:
2568:
2529:
2488:
2453:
2394:
2343:
2292:
2242:
2188:
2140:
2086:
2047:
2012:
1963:
1930:Science's STKE
1920:
1885:
1864:(7): 1357–61.
1844:
1830:
1768:
1750:
1732:
1711:
1689:
1687:
1684:
1655:
1652:
1637:spatial memory
1602:
1582:
1497:
1494:
1488:
1481:
1462:
1459:
1376:
1373:
1353:
1346:
1343:
1301:
1298:
1260:
1257:
1171:
1168:
1054:
1053:
1050:
1049:
1044:
1034:
1033:
1027:
1026:
1023:
1022:
1020:
1018:
1011:
1010:
1003:
996:
992:
991:
988:
987:
969:
968:
962:
959:
958:
940:
939:
933:
929:
928:
925:
924:
906:
905:
899:
896:
895:
877:
876:
870:
866:
865:
862:
861:
853:
852:
846:
843:
842:
834:
833:
827:
821:
820:
817:
816:
808:
807:
801:
798:
797:
789:
788:
782:
776:
775:
772:
771:
763:
762:
756:
753:
752:
744:
743:
737:
731:
730:
725:
720:
716:
715:
705:
704:
701:
700:
689:
688:
686:
685:
680:
675:
670:
665:
660:
655:
649:
647:
643:
642:
640:
639:
634:
629:
624:
619:
613:
611:
607:
606:
604:
603:
598:
593:
588:
583:
577:
575:
571:
570:
560:
559:
556:
555:
552:
551:
548:
547:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
505:
501:
497:
493:
492:lacrimal gland
489:
485:
481:
477:
473:
470:
469:
458:
455:
454:
452:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
284:
278:
277:
269:
268:
256:
255:
252:
251:
243:
239:
238:
230:
227:
222:
216:
215:
206:
199:
193:
189:
188:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3751:
3740:
3737:
3736:
3734:
3721:
3717:
3712:
3707:
3704:(6): 1050–7.
3703:
3699:
3695:
3688:
3685:
3680:
3676:
3672:
3668:
3663:
3658:
3654:
3650:
3646:
3639:
3636:
3631:
3627:
3622:
3617:
3613:
3609:
3605:
3601:
3597:
3590:
3587:
3582:
3578:
3573:
3568:
3565:(3): 305–10.
3564:
3560:
3556:
3549:
3546:
3541:
3537:
3533:
3529:
3525:
3521:
3517:
3513:
3505:
3502:
3497:
3493:
3488:
3483:
3478:
3473:
3469:
3465:
3461:
3454:
3451:
3446:
3442:
3438:
3434:
3430:
3426:
3423:(3): 281–91.
3422:
3418:
3410:
3407:
3402:
3398:
3393:
3388:
3384:
3380:
3376:
3369:
3367:
3363:
3358:
3354:
3349:
3344:
3339:
3334:
3330:
3326:
3322:
3315:
3312:
3307:
3303:
3298:
3293:
3289:
3285:
3281:
3274:
3271:
3266:
3262:
3257:
3252:
3247:
3242:
3238:
3234:
3230:
3226:
3222:
3215:
3212:
3207:
3203:
3198:
3193:
3189:
3185:
3181:
3177:
3173:
3169:
3165:
3158:
3155:
3150:
3146:
3141:
3136:
3132:
3128:
3125:(3): 435–45.
3124:
3120:
3116:
3109:
3106:
3101:
3097:
3092:
3087:
3083:
3079:
3076:(4): 432–43.
3075:
3071:
3067:
3060:
3058:
3054:
3049:
3045:
3040:
3035:
3031:
3027:
3023:
3016:
3014:
3012:
3010:
3006:
3001:
2997:
2992:
2987:
2982:
2977:
2974:(3): 752–61.
2973:
2969:
2968:FASEB Journal
2965:
2958:
2956:
2954:
2952:
2950:
2946:
2941:
2937:
2932:
2927:
2923:
2919:
2916:(6): 636–45.
2915:
2911:
2907:
2900:
2897:
2892:
2888:
2883:
2878:
2873:
2868:
2864:
2860:
2856:
2849:
2846:
2841:
2837:
2833:
2829:
2825:
2821:
2814:
2812:
2808:
2803:
2799:
2795:
2791:
2786:
2781:
2777:
2773:
2769:
2762:
2759:
2754:
2750:
2746:
2742:
2738:
2734:
2730:
2726:
2719:
2717:
2713:
2708:
2704:
2700:
2696:
2691:
2686:
2683:(1): 110–22.
2682:
2678:
2674:
2667:
2664:
2659:
2655:
2650:
2645:
2641:
2637:
2633:
2629:
2625:
2618:
2616:
2614:
2610:
2605:
2601:
2596:
2591:
2587:
2583:
2579:
2572:
2569:
2564:
2560:
2556:
2552:
2549:(2): 109–19.
2548:
2544:
2540:
2533:
2530:
2525:
2521:
2516:
2511:
2507:
2503:
2499:
2492:
2489:
2484:
2480:
2476:
2472:
2468:
2464:
2457:
2454:
2449:
2445:
2440:
2435:
2430:
2425:
2421:
2417:
2413:
2409:
2405:
2398:
2395:
2390:
2386:
2381:
2376:
2371:
2366:
2362:
2358:
2354:
2347:
2344:
2339:
2335:
2330:
2325:
2320:
2315:
2311:
2307:
2303:
2296:
2293:
2288:
2284:
2279:
2274:
2270:
2266:
2262:
2258:
2254:
2246:
2243:
2238:
2234:
2229:
2224:
2220:
2216:
2212:
2208:
2204:
2197:
2195:
2193:
2189:
2184:
2180:
2175:
2170:
2166:
2162:
2158:
2151:
2149:
2147:
2145:
2141:
2136:
2132:
2128:
2124:
2119:
2114:
2110:
2106:
2102:
2095:
2093:
2091:
2087:
2082:
2078:
2074:
2070:
2066:
2062:
2054:
2052:
2048:
2043:
2039:
2035:
2031:
2028:(3): 258–69.
2027:
2023:
2016:
2013:
2008:
2004:
1999:
1994:
1990:
1986:
1983:(1): 249–53.
1982:
1978:
1974:
1967:
1964:
1959:
1955:
1951:
1947:
1943:
1939:
1935:
1931:
1924:
1921:
1916:
1912:
1908:
1904:
1901:(12): 625–8.
1900:
1896:
1889:
1886:
1881:
1877:
1872:
1867:
1863:
1859:
1855:
1848:
1845:
1840:
1834:
1831:
1826:
1822:
1817:
1812:
1808:
1804:
1800:
1796:
1792:
1785:
1783:
1781:
1779:
1777:
1775:
1773:
1769:
1764:
1760:
1754:
1751:
1746:
1742:
1736:
1733:
1729:
1725:
1720:
1718:
1716:
1712:
1708:
1704:
1699:
1697:
1695:
1691:
1685:
1683:
1681:
1677:
1673:
1669:
1665:
1661:
1653:
1651:
1649:
1644:
1642:
1638:
1634:
1630:
1626:
1622:
1618:
1614:
1613:knockout mice
1610:
1605:
1598:
1594:
1590:
1586:
1578:
1574:
1570:
1566:
1562:
1558:
1554:
1550:
1546:
1541:
1538:
1534:
1530:
1526:
1522:
1518:
1514:
1510:
1506:
1503:
1495:
1493:
1492:lymphocytes.
1491:
1484:
1477:
1472:
1468:
1460:
1458:
1456:
1452:
1449:
1444:
1439:
1435:
1431:
1427:
1423:
1419:
1415:
1411:
1407:
1403:
1399:
1395:
1391:
1387:
1383:
1374:
1372:
1370:
1365:
1361:
1357:
1344:
1342:
1339:
1335:
1331:
1327:
1323:
1319:
1315:
1306:
1299:
1297:
1295:
1291:
1290:glycosylation
1287:
1283:
1279:
1274:
1270:
1266:
1258:
1256:
1254:
1250:
1246:
1242:
1241:
1236:
1232:
1228:
1224:
1221:
1220:
1215:
1211:
1207:
1203:
1199:
1195:
1191:
1187:
1183:
1182:
1177:
1169:
1167:
1165:
1161:
1157:
1156:tumorigenesis
1153:
1149:
1148:immune system
1145:
1141:
1137:
1133:
1129:
1125:
1121:
1117:
1113:
1109:
1105:
1101:
1096:
1094:
1090:
1086:
1082:
1078:
1073:
1071:
1068:
1064:
1060:
1048:
1043:
1039:
1035:
1032:
1028:
1021:
1019:
1016:
1012:
1008:
1004:
1001:
997:
993:
986:
984:
980:
976:
970:
966:
963:
957:
955:
951:
947:
941:
937:
934:
930:
923:
921:
917:
913:
907:
903:
900:
894:
892:
888:
884:
878:
874:
871:
869:RefSeq (mRNA)
867:
860:
859:
854:
850:
847:
841:
840:
835:
831:
828:
826:
822:
815:
814:
809:
805:
802:
796:
795:
790:
786:
783:
781:
777:
770:
769:
764:
760:
757:
751:
750:
745:
741:
738:
736:
732:
729:
726:
724:
721:
717:
714:
710:
706:
699:
695:
690:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
653:ion transport
651:
650:
648:
645:
644:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
614:
612:
609:
608:
602:
599:
597:
594:
592:
589:
587:
584:
582:
579:
578:
576:
573:
572:
569:
568:Gene ontology
565:
561:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
500:otolith organ
499:
495:
491:
487:
483:
479:
475:
474:
471:
467:
462:
459:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
412:
409:
405:
400:
397:
396:
393:
391:
387:
385:
384:
380:
379:
376:
374:
370:
366:
362:
358:
350:
345:
341:
337:
332:
322:
318:
311:
304:
298:
291:
283:
279:
275:
270:
266:
261:
257:
249:
244:
240:
236:
231:
221:
217:
210:
203:
197:
190:
186:
180:
176:
172:
167:
163:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
3701:
3697:
3687:
3652:
3648:
3638:
3606:(1): 65–73.
3603:
3599:
3589:
3562:
3558:
3548:
3518:(3): 260–7.
3515:
3511:
3504:
3467:
3463:
3453:
3420:
3416:
3409:
3382:
3378:
3328:
3324:
3314:
3287:
3283:
3273:
3228:
3224:
3214:
3171:
3167:
3157:
3122:
3118:
3108:
3073:
3069:
3032:(93): ra67.
3029:
3025:
2971:
2967:
2913:
2909:
2899:
2862:
2858:
2848:
2823:
2820:Biochemistry
2819:
2775:
2771:
2761:
2728:
2724:
2680:
2676:
2666:
2631:
2627:
2585:
2581:
2571:
2546:
2543:Cell Calcium
2542:
2532:
2505:
2501:
2491:
2469:(1): 240–6.
2466:
2462:
2456:
2411:
2407:
2397:
2360:
2356:
2346:
2309:
2305:
2295:
2260:
2256:
2245:
2210:
2206:
2164:
2160:
2108:
2104:
2067:(1): 131–7.
2064:
2060:
2025:
2021:
2015:
1980:
1976:
1966:
1936:(286): re7.
1933:
1929:
1923:
1898:
1894:
1888:
1861:
1857:
1847:
1833:
1798:
1794:
1762:
1753:
1744:
1735:
1670:(ICRACM) or
1657:
1654:Interactions
1645:
1564:
1560:
1552:
1548:
1544:
1542:
1535:channels in
1528:
1524:
1516:
1512:
1508:
1499:
1464:
1447:
1437:
1422:thapsigargin
1378:
1368:
1363:
1359:
1348:
1311:
1285:
1262:
1248:
1238:
1226:
1222:
1217:
1213:
1209:
1201:
1185:
1179:
1175:
1173:
1166:conditions.
1097:
1074:
1066:
1058:
1057:
979:NP_001350277
975:NP_001074572
972:
950:NP_001162589
946:NP_001162588
943:
920:NM_001363348
912:NM_001081103
909:
891:NM_001169118
887:NM_001169117
880:
856:
837:
811:
792:
766:
747:
727:
722:
388:
381:
108:External IDs
67:
1635:-dependent
1633:hippocampus
1629:homeostasis
1443:coiled-coil
1338:coiled-coil
1320:Ca-binding
1253:prokaryotes
1216:as well as
512:granulocyte
426:gallbladder
347:54,278,399
334:54,155,841
246:27,025,381
233:26,857,601
86:Identifiers
1730:, May 2017
1709:, May 2017
1686:References
1623:and other
1547:or murine
1471:cell lines
1418:calmodulin
1273:C-terminal
1269:N-terminal
1235:eukaryotes
1231:amino acid
1206:eukaryotes
1198:centromere
1130:, such as
450:lymph node
392:(ortholog)
129:HomoloGene
1557:myoblasts
1527:., using
1521:cytosolic
1505:knockdown
1390:histidine
1330:α-helical
1174:In 2001,
1144:myoblasts
1120:cytosolic
983:NP_473424
954:NP_065911
916:NM_054083
883:NM_020860
713:Orthologs
137:GeneCards
3733:Category
3720:19111578
3679:31387679
3671:19845919
3630:10638968
3581:10861509
3540:13411377
3496:17002787
3445:31862636
3437:18398573
3401:20028655
3357:20436167
3306:16766533
3265:16537481
3206:16208375
3149:15866891
3100:18327260
3048:19843959
3000:17905723
2940:17486119
2891:17224452
2840:18484746
2802:33126543
2794:22498042
2753:22135544
2745:16906149
2707:15447873
2699:18854159
2658:18160041
2563:12810053
2524:17020874
2483:18166150
2448:17075073
2389:16751269
2338:16807233
2287:17965774
2237:16005298
2183:17702753
2135:16570108
2127:16860747
2081:11983428
2042:18342539
1958:31699798
1950:15928333
1915:14659692
1880:18385221
1825:11463338
1726:–
1705:–
1641:synaptic
1569:myotubes
1545:in vitro
1529:in vitro
1496:Function
1448:In vitro
1438:in vitro
1414:peptides
1369:in vitro
1364:in vitro
1356:receptor
1280:. Their
1237:such as
1164:ischemic
1093:isoforms
1031:Wikidata
692:Sources:
637:membrane
434:appendix
3649:Traffic
3621:2363206
3532:9365833
3487:1592108
3348:2903423
3256:1449642
3233:Bibcode
3197:1618826
3176:Bibcode
3140:2171946
3091:2737533
2991:3601890
2931:2699187
2882:3309402
2772:Traffic
2649:2680164
2604:9346910
2439:1636519
2416:Bibcode
2380:1482614
2329:1633822
2278:2040319
2228:3186072
2007:9007998
1998:2143507
1816:1221997
1728:Ensembl
1707:Ensembl
1597:T cells
1593:nucleus
1565:in vivo
1561:in vivo
1549:in vivo
1476:T cells
1398:proline
1386:proline
1360:in vivo
1318:EF-hand
1286:in vivo
1194:introns
1192:and 11
1152:neurons
1100:calcium
1063:protein
825:UniProt
780:Ensembl
719:Species
698:QuickGO
508:utricle
367:pattern
125:2151156
93:Aliases
3718:
3677:
3669:
3628:
3618:
3579:
3538:
3530:
3494:
3484:
3470:: 39.
3443:
3435:
3399:
3355:
3345:
3304:
3263:
3253:
3204:
3194:
3168:Nature
3147:
3137:
3098:
3088:
3046:
2998:
2988:
2938:
2928:
2889:
2879:
2838:
2800:
2792:
2751:
2743:
2705:
2697:
2656:
2646:
2602:
2561:
2522:
2481:
2446:
2436:
2387:
2377:
2336:
2326:
2285:
2275:
2235:
2225:
2181:
2133:
2125:
2079:
2040:
2005:
1995:
1956:
1948:
1913:
1878:
1823:
1813:
1573:T cell
1537:HEK293
1465:STIM2
1455:HEK293
1410:lysine
1396:- and
1394:serine
1388:- and
1282:domain
1227:D-Stim
1017:search
1015:PubMed
858:P83093
839:Q9P246
768:116873
735:Entrez
538:BioGPS
442:rectum
430:spleen
225:4p15.2
117:610841
3675:S2CID
3536:S2CID
3441:S2CID
2798:S2CID
2749:S2CID
2703:S2CID
2131:S2CID
1954:S2CID
1660:STIM1
1599:into
1553:et al
1525:et al
1517:et al
1513:et al
1509:et al
1502:siRNA
1478:into
1426:SERCA
1424:(the
1322:motif
1314:lumen
1278:BLAST
1214:STIM2
1210:STIM1
1190:exons
1186:STIM2
1181:STIM1
1176:STIM2
1077:STIM1
1067:STIM2
1061:is a
749:57620
728:Mouse
723:Human
694:Amigo
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
141:STIM2
133:32490
100:STIM2
22:STIM2
3716:PMID
3702:1793
3667:PMID
3626:PMID
3577:PMID
3528:PMID
3492:PMID
3433:PMID
3397:PMID
3353:PMID
3302:PMID
3261:PMID
3202:PMID
3145:PMID
3096:PMID
3044:PMID
2996:PMID
2936:PMID
2887:PMID
2836:PMID
2790:PMID
2741:PMID
2695:PMID
2677:Cell
2654:PMID
2628:Cell
2600:PMID
2559:PMID
2520:PMID
2479:PMID
2444:PMID
2385:PMID
2334:PMID
2283:PMID
2233:PMID
2179:PMID
2123:PMID
2077:PMID
2065:1596
2038:PMID
2003:PMID
1946:PMID
1934:2005
1911:PMID
1876:PMID
1821:PMID
1672:TRPC
1668:Orai
1589:NFAT
1579:and
1467:mRNA
1249:STIM
1223:Stim
1212:and
1202:STIM
1170:Gene
1150:and
1140:SOCE
1136:TRPC
1132:Orai
1116:SOCE
1112:SOCE
1070:gene
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
113:OMIM
70:2L5Y
51:RCSB
48:PDBe
3706:doi
3657:doi
3616:PMC
3608:doi
3567:doi
3520:doi
3482:PMC
3472:doi
3425:doi
3387:doi
3383:184
3343:PMC
3333:doi
3329:285
3292:doi
3288:281
3251:PMC
3241:doi
3229:103
3192:PMC
3184:doi
3172:437
3135:PMC
3127:doi
3123:169
3086:PMC
3078:doi
3034:doi
2986:PMC
2976:doi
2926:PMC
2918:doi
2877:PMC
2867:doi
2863:282
2828:doi
2780:doi
2733:doi
2685:doi
2681:135
2644:PMC
2636:doi
2632:131
2590:doi
2586:272
2551:doi
2510:doi
2506:281
2471:doi
2467:369
2434:PMC
2424:doi
2412:103
2375:PMC
2365:doi
2361:103
2324:PMC
2314:doi
2310:281
2273:PMC
2265:doi
2261:117
2223:PMC
2215:doi
2169:doi
2165:282
2113:doi
2069:doi
2030:doi
2026:163
1993:PMC
1985:doi
1938:doi
1903:doi
1866:doi
1811:PMC
1803:doi
1799:357
1664:SOC
1533:SOC
1485:or
1382:SOC
1334:ERM
1265:aas
1134:or
546:n/a
343:End
242:End
145:OMA
121:MGI
41:PDB
3735::
3714:.
3700:.
3696:.
3673:.
3665:.
3653:10
3651:.
3647:.
3624:.
3614:.
3604:82
3602:.
3598:.
3575:.
3563:89
3561:.
3557:.
3534:.
3526:.
3516:20
3514:.
3490:.
3480:.
3466:.
3462:.
3439:.
3431:.
3421:88
3419:.
3395:.
3381:.
3377:.
3365:^
3351:.
3341:.
3327:.
3323:.
3300:.
3286:.
3282:.
3259:.
3249:.
3239:.
3227:.
3223:.
3200:.
3190:.
3182:.
3170:.
3166:.
3143:.
3133:.
3121:.
3117:.
3094:.
3084:.
3072:.
3068:.
3056:^
3042:.
3028:.
3024:.
3008:^
2994:.
2984:.
2972:22
2970:.
2966:.
2948:^
2934:.
2924:.
2912:.
2908:.
2885:.
2875:.
2861:.
2857:.
2834:.
2824:47
2822:.
2810:^
2796:.
2788:.
2776:13
2774:.
2770:.
2747:.
2739:.
2727:.
2715:^
2701:.
2693:.
2679:.
2675:.
2652:.
2642:.
2630:.
2626:.
2612:^
2598:.
2584:.
2580:.
2557:.
2547:34
2545:.
2541:.
2518:.
2504:.
2500:.
2477:.
2465:.
2442:.
2432:.
2422:.
2410:.
2406:.
2383:.
2373:.
2359:.
2355:.
2332:.
2322:.
2308:.
2304:.
2281:.
2271:.
2259:.
2255:.
2231:.
2221:.
2211:15
2209:.
2205:.
2191:^
2177:.
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