544:
521:
3679:
3664:
418:
443:
3649:
3724:
802:
795:
3709:
3694:
550:
449:
1800:
lymphatics and the blood vessels form abnormal shunts, leading to leakage of blood into the lymphatic system. The reason for this phenotype was identified by a genetic fate mapping approach, showing that Syk is expressed in myeloid cells which orchestrate the proper separation of lymphatics and blood system during embryogenesis and beyond. Thus, Syk is an essential regulator of the lymphatic system development in mice.
39:
5034:
1799:
Mice that lack Syk completely (Syk, Syk-knockout) die during embryonic development around midgestation. They show severe defects in the development of the lymphatic system. Normally, the lymphatic system and the blood system are strictly separated from each other. However, in Syk deficient mice the
65:
2908:
Kim MK, Pan XQ, Huang ZY, Hunter S, Hwang PH, Indik ZK, Schreiber AD (January 2001). "Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis".
3678:
3663:
2708:
Bertagnolo V, Marchisio M, Brugnoli F, Bavelloni A, Boccafogli L, Colamussi ML, Capitani S (April 2001). "Requirement of tyrosine-phosphorylated Vav for morphological differentiation of all-trans-retinoic acid-treated HL-60 cells".
3352:"Association of a p95 Vav-containing signaling complex with the FcepsilonRI gamma chain in the RBL-2H3 mast cell line. Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex"
3648:
1840:
Given the central role of SYK in transmission of activating signals within B-cells, a suppression of this tyrosine kinase might aid in the treatment of B cell malignancies and
3270:"Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation"
557:
456:
1817:
4179:
3723:
3531:
Schymeinsky J, MĂłcsai A, Walzog B (August 2007). "Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications".
4603:
3764:
3708:
3395:
Turner M, Schweighoffer E, Colucci F, Di Santo JP, Tybulewicz VL (March 2000). "Tyrosine kinase SYK: essential functions for immunoreceptor signalling".
2738:"Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323"
1415:
1748:
separated by a linker domain. However, activation of SYK relies less on phosphorylation by Src family kinases than ZAP70. SYK and ZAP70 share a common
1396:
379:
1909:
The role of Syk in epithelial malignancies is controversial. Several authors have suggested that abnormal Syk function facilitates transformation in
4476:
3902:
3687:: SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR
3672:: SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR
4217:
3859:
3628:
2084:
3693:
2066:
5054:
3887:
2116:
Chan AC, Iwashima M, Turck CW, Weiss A (November 1992). "ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain".
3072:"Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement"
543:
4255:
4246:
3946:
3941:
3936:
3931:
4140:
4131:
1935:(breast DCIS, which can become invasive), it is believed that the cancer has a markedly increased tendency to invade and metastasize.
2779:"Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils"
1654:
1647:
520:
4753:
3922:
1808:
Abnormal function of Syk has been implicated in several instances of hematopoietic malignancies including translocations involving
3825:
2102:
2053:
2032:
3757:
3459:
Yanagi S, Inatome R, Takano T, Yamamura H (November 2001). "Syk expression and novel function in a wide variety of tissues".
4909:
2255:"Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions"
2049:
2159:
Ku G, Malissen B, Mattei MG (1994). "Chromosomal location of the Syk and ZAP-70 tyrosine kinase genes in mice and humans".
442:
417:
62:
3970:
5024:
2028:
4401:
4333:
4324:
2646:
Blancato J, Graves A, Rashidi B, Moroni M, Tchobe L, Ozdemirli M, Kallakury B, Makambi KH, Marian C, Mueller SC (2014).
2443:
Roskoski R (2016). "Ibrutinib inhibition of Bruton protein-tyrosine kinase (BTK) in the treatment of B cell neoplasms".
1852:
1741:
359:
2570:
Paris D, Ait-Ghezala G, Bachmeier C, Laco G, Beaulieu-Abdelahad D, Lin Y, Jin C, Crawford F, Mullan M (December 2014).
1928:
Without Syk, the protein it makes, and genetic disruption in a panel of 55 genes thought also to be controlled by Syk,
4634:
4462:
1944:
1753:
4678:
4145:
556:
455:
4894:
3170:"Human spleen tyrosine kinase p72Syk associates with the Src-family kinase p53/56Lyn and a 120-kDa phosphoprotein"
5059:
5010:
4997:
4984:
4971:
4958:
4945:
4932:
3750:
3621:
2204:"Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes"
1829:
4904:
549:
448:
4858:
4801:
3795:
3781:
3579:
1932:
1910:
1763:
While Syk and ZAP70 are primarily expressed in hematopoietic tissues, a variety of tissues express Syk. Within
1460:
367:
3657:: CRYSTAL STRUCTURE OF THE TANDEM SH2 DOMAIN OF THE SYK KINASE BOUND TO A DUALLY TYROSINE-PHOSPHORYLATED ITAM
3229:"Relocation of Syk protein-tyrosine kinase to the actin filament network and subsequent association with Fak"
4806:
4519:
4510:
2527:
Scott IC, Scott DL (2014). "Spleen tyrosine kinase inhibitors for rheumatoid arthritis: where are we now?".
1883:
1441:
2396:"Targeting B-cell receptor signaling kinases in chronic lymphocytic leukemia: the promise of entospletinib"
1821:
3808:
1898:
4827:
4746:
4471:
4155:
2572:"The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation"
1825:
4899:
1779:. Syk plays a similar role in transmitting signals from a variety of cell surface receptors including
3614:
3181:
2659:
1914:
431:
346:
3121:"Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex"
2987:"Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3"
4863:
4169:
2826:
Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, Handa M, Ikebuchi K, Ikeda H (May 2001).
1626:
1601:
1597:
1593:
1563:
1538:
1534:
1530:
4796:
4553:
4543:
4534:
4362:
4353:
3556:
3519:
2552:
2184:
2141:
1841:
391:
3742:
3311:"Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product"
1630:
1605:
1567:
1542:
2946:"Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases"
4587:
3586:
3548:
3511:
3476:
3447:
3412:
3373:
3332:
3291:
3250:
3209:
3150:
3101:
3052:
3008:
2967:
2926:
2890:
2849:
2808:
2759:
2736:
Lupher ML, Rao N, Lill NL, Andoniou CE, Miyake S, Clark EA, Druker B, Band H (December 1998).
2718:
2687:
2603:
2544:
2509:
2460:
2425:
2376:
2335:
2286:
2235:
2176:
2133:
1757:
339:
55:
4842:
4837:
4811:
4739:
3864:
3850:
3540:
3501:
3468:
3437:
3404:
3363:
3322:
3281:
3240:
3199:
3189:
3140:
3132:
3091:
3083:
3042:
2998:
2957:
2918:
2880:
2839:
2798:
2790:
2749:
2677:
2667:
2593:
2583:
2536:
2499:
2491:
2452:
2415:
2407:
2366:
2325:
2317:
2276:
2266:
2225:
2215:
2168:
2125:
636:
567:
511:
466:
4111:
801:
794:
4889:
4873:
4786:
4452:
4121:
4106:
4096:
4091:
4071:
4066:
4061:
4056:
4051:
4042:
3777:
1864:
1816:. Constitutive Syk activity can transform B cells. Several transforming viruses contain "
1776:
1772:
1737:
611:
1331:
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
387:
3185:
2663:
5038:
4927:
4868:
4582:
4577:
4572:
3956:
3773:
3145:
3120:
3096:
3071:
2803:
2778:
2682:
2647:
2598:
2571:
2504:
2479:
2420:
2395:
2330:
2305:
2281:
2254:
2230:
2203:
1922:
3575:
3442:
3425:
3408:
3327:
3310:
2885:
2868:
1330:
1325:
1320:
1315:
1310:
1305:
1300:
1295:
1290:
1285:
1280:
1275:
1270:
1265:
1260:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1215:
1210:
1205:
1200:
1195:
1190:
1185:
1180:
1175:
1170:
1165:
1160:
1155:
1150:
1145:
1140:
1135:
1130:
1125:
1120:
1115:
1110:
1105:
1100:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
5048:
4832:
4791:
4018:
3879:
3595:
3245:
3228:
3204:
3169:
2129:
1918:
1860:
830:
3560:
3523:
2556:
2188:
2145:
38:
4781:
4563:
4274:
4265:
4009:
2353:
Böhmer R, Neuhaus B, Bühren S, Zhang D, Stehling M, Böck B, Kiefer F (March 2010).
1879:
1856:
629:
408:
2867:
Ibarrola I, Vossebeld PJ, Homburg CH, Thelen M, Roos D, Verhoeven AJ (July 1997).
2622:
2253:
Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al. (2018).
371:
2672:
2495:
2371:
2354:
395:
5005:
4940:
4776:
3286:
3269:
3087:
2648:"SYK allelic loss and the role of Syk-regulated genes in breast cancer survival"
2089:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2071:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1894:
1890:
1784:
5033:
3309:
Deckert M, Tartare-Deckert S, Couture C, Mustelin T, Altman A (December 1996).
3174:
Proceedings of the
National Academy of Sciences of the United States of America
2869:"Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa"
2456:
712:
4688:
4683:
4673:
4668:
4659:
4608:
4524:
4414:
3506:
3489:
2540:
1875:(PI3K inhibitor - CAL-101 / GS-1101) showed activity in the diseases as well.
1872:
1809:
1745:
528:
425:
375:
3368:
3351:
3003:
2986:
2844:
2827:
2754:
2737:
2411:
2271:
2220:
4979:
4953:
3268:
Dustin LB, Plas DR, Wong J, Hu YT, Soto C, Chan AC, Thomas ML (March 1999).
2962:
2945:
2588:
1868:
1749:
1360:
772:
650:
595:
582:
494:
481:
383:
3552:
3515:
3480:
3472:
3451:
3416:
3295:
3136:
3105:
3056:
3047:
3030:
2930:
2922:
2853:
2812:
2722:
2691:
2607:
2548:
2513:
2464:
2429:
2380:
2339:
2306:"The SYK tyrosine kinase: a crucial player in diverse biological functions"
2290:
2239:
350:, p72-Syk, spleen tyrosine kinase, spleen associated tyrosine kinase, IMD82
3377:
3336:
3254:
3213:
3194:
3154:
3012:
2971:
2894:
2763:
2180:
2137:
1694:
1689:
17:
4423:
3830:
3544:
1951:
1848:
1788:
1678:
1505:
1486:
3070:
Saci A, Liu WQ, Vidal M, Garbay C, Rendu F, Bachelot-Loza C (May 2002).
3029:
Ganju RK, Brubaker SA, Chernock RD, Avraham S, Groopman JE (June 2000).
3732:: Crystal structure of the syk tyrosine kinase domain with Staurosporin
3600:
3590:
2794:
2172:
1472:
1427:
316:
312:
308:
304:
300:
296:
292:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
4992:
4762:
4712:
3975:
3911:
3906:
1962:
1929:
1768:
1764:
1714:
1662:
1382:
2355:"Regulation of developmental lymphangiogenesis by Syk(+) leukocytes"
2321:
2202:
Fasbender F, Claus M, Wingert S, Sandusky M, Watzl C (2017-07-07).
4966:
4500:
4378:
4343:
4338:
4314:
4116:
4101:
4086:
4081:
4076:
4028:
4023:
3999:
3994:
3985:
3897:
3892:
3869:
3840:
3835:
3717:: Crystal structure of the syk tyrosine kinase domain with Gleevec
3031:"Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk"
1998:
1733:
2828:"CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk"
1345:
1341:
4618:
4548:
4495:
4486:
4447:
4438:
4428:
4309:
4300:
4290:
4236:
4227:
4212:
4203:
4193:
4188:
4164:
3965:
3817:
2004:
1992:
1974:
1956:
1813:
1780:
1721:
1091:
transmembrane receptor protein tyrosine kinase signaling pathway
363:
4735:
4399:
3793:
3746:
3610:
2623:"A Phase III Trial of Nilvadipine to Treat Alzheimer's Disease"
1897:
phosphorylation and hence has been proposed as a treatment for
810:
4649:
4644:
4639:
4613:
3606:
1986:
1980:
1968:
1917:
while other authors have suggested a tumor suppressor role in
1106:
cellular response to low-density lipoprotein particle stimulus
1096:
regulation of tumor necrosis factor-mediated signaling pathway
2873:
Biochimica et
Biophysica Acta (BBA) - Molecular Cell Research
1291:
collagen-activated tyrosine kinase receptor signaling pathway
3585:
Overview of all the structural information available in the
3168:
Sidorenko SP, Law CL, Chandran KA, Clark EA (January 1995).
1296:
positive regulation of peptidyl-tyrosine autophosphorylation
1086:
Fc-gamma receptor signaling pathway involved in phagocytosis
4731:
1326:
positive regulation of protein-containing complex assembly
950:
extrinsic component of cytoplasmic side of plasma membrane
1271:
positive regulation of gamma-delta T cell differentiation
1056:
positive regulation of cell adhesion mediated by integrin
3350:
Song JS, Gomez J, Stancato LF, Rivera J (October 1996).
1855:. Syk inhibitors are in clinical development, including
1771:, respectively, Syk and ZAP70 transmit signals from the
1166:
positive regulation of alpha-beta T cell differentiation
1146:
positive regulation of peptidyl-tyrosine phosphorylation
619:
3426:"Xid-like phenotypes: a B cell signalosome takes shape"
1847:
Syk inhibition has been proposed as a therapy for both
1036:
regulation of DNA-binding transcription factor activity
1136:
positive regulation of alpha-beta T cell proliferation
859:
non-membrane spanning protein tyrosine kinase activity
5022:
3702:: Crystal structure of apo syk tyrosine kinase domain
3119:
Thome M, Duplay P, Guttinger M, Acuto O (June 1995).
784:
1893:
has been shown to regulate amyloid-β production and
1820:" (ITAMs) which lead to activation of Syk including
1111:
stimulatory C-type lectin receptor signaling pathway
4918:
4882:
4851:
4820:
4769:
4697:
4658:
4627:
4596:
4562:
4533:
4509:
4485:
4461:
4437:
4413:
4371:
4352:
4323:
4299:
4283:
4264:
4245:
4226:
4202:
4178:
4154:
4130:
4041:
4008:
3984:
3955:
3921:
3878:
3849:
3816:
3807:
3490:"Complement-mediated phagocytosis--the role of Syk"
3461:
3424:Fruman DA, Satterthwaite AB, Witte ON (July 2000).
1619:
1586:
1556:
1523:
1276:
positive regulation of type I interferon production
2944:Deckert M, Elly C, Altman A, Liu YC (April 1998).
2045:
2043:
2041:
2024:
2022:
2020:
1321:positive regulation of cold-induced thermogenesis
1126:macrophage activation involved in immune response
1076:positive regulation of calcium-mediated signaling
1011:neutrophil activation involved in immune response
566:
465:
1221:enzyme linked receptor protein signaling pathway
1201:leukocyte activation involved in immune response
3227:Sada K, Minami Y, Yamamura H (September 1997).
3024:
3022:
2703:
2701:
2304:MĂłcsai A, Ruland J, Tybulewicz VL (June 2010).
1306:positive regulation of interleukin-4 production
1006:positive regulation of receptor internalization
2050:GRCm38: Ensembl release 89: ENSMUSG00000021457
1241:positive regulation of mast cell degranulation
1171:cellular response to molecule of fungal origin
4747:
3758:
3622:
2777:Melander F, Andersson T, Dib K (March 2003).
1191:positive regulation of B cell differentiation
8:
2029:GRCh38: Ensembl release 89: ENSG00000165025
1901:and has entered phase III clinical trials.
4754:
4740:
4732:
4410:
4396:
3813:
3804:
3790:
3765:
3751:
3743:
3629:
3615:
3607:
2480:"Idelalisib in the management of lymphoma"
1356:
826:
607:
506:
403:
73:
3578:at the U.S. National Library of Medicine
3505:
3441:
3367:
3326:
3285:
3244:
3203:
3193:
3144:
3095:
3046:
3002:
2985:Chung J, Gao AG, Frazier WA (June 1997).
2961:
2884:
2843:
2802:
2753:
2681:
2671:
2597:
2587:
2503:
2419:
2370:
2329:
2280:
2270:
2229:
2219:
2103:"Entrez Gene: SYK Spleen tyrosine kinase"
1818:Immunoreceptor Tyrosine Activation Motifs
1216:regulation of superoxide anion generation
1316:interleukin-3-mediated signaling pathway
1311:interleukin-2-mediated signaling pathway
1246:regulation of arachidonic acid secretion
864:protein serine/threonine kinase activity
5029:
3644:
2016:
1031:cell surface receptor signaling pathway
1236:positive regulation of bone resorption
1176:regulation of neutrophil degranulation
28:
3599:(Tyrosine-protein kinase SYK) at the
1206:peptidyl-tyrosine autophosphorylation
1021:Fc-epsilon receptor signaling pathway
571:
532:
527:
470:
429:
424:
7:
3125:The Journal of Experimental Medicine
1871:(PCI-32765) which inhibits BTK, and
3356:The Journal of Biological Chemistry
3035:The Journal of Biological Chemistry
2991:The Journal of Biological Chemistry
2950:The Journal of Biological Chemistry
2742:The Journal of Biological Chemistry
2576:The Journal of Biological Chemistry
1736:, is a member of the Syk family of
1211:integrin-mediated signaling pathway
1141:regulation of ERK1 and ERK2 cascade
2400:Therapeutic Advances in Hematology
1717:which in humans is encoded by the
1616:
1583:
1553:
1520:
1496:
1477:
1451:
1432:
1406:
1387:
1066:regulation of platelet aggregation
789:
707:
645:
624:
25:
2711:Cell Growth & Differentiation
1266:regulation of platelet activation
1256:peptidyl-tyrosine phosphorylation
1226:intracellular signal transduction
1071:B cell receptor signaling pathway
5032:
3722:
3707:
3692:
3677:
3662:
3647:
3246:10.1111/j.1432-1033.1997.00827.x
3233:European Journal of Biochemistry
1878:The orally active SYK inhibitor
1156:leukotriene biosynthetic process
884:protein tyrosine kinase activity
800:
793:
759:lumbar subsegment of spinal cord
555:
548:
542:
519:
454:
447:
441:
416:
37:
1251:peptidyl-serine phosphorylation
1101:serotonin secretion by platelet
919:interleukin-15 receptor binding
909:phosphotyrosine residue binding
3488:Tohyama Y, Yamamura H (2006).
2394:Sharman J, Di Paolo J (2016).
811:More reference expression data
773:More reference expression data
1:
4402:Non-receptor tyrosine kinases
3443:10.1016/S1074-7613(00)00002-9
3409:10.1016/S0167-5699(99)01574-1
3328:10.1016/S1074-7613(00)80273-3
2886:10.1016/S0167-4889(97)00034-7
1742:non-receptor tyrosine kinases
1131:defense response to bacterium
1061:cell population proliferation
540:
439:
2673:10.1371/journal.pone.0087610
2496:10.1182/blood-2016-02-702761
2478:Cheah CY, Fowler NH (2016).
2372:10.1016/j.devcel.2010.01.009
2130:10.1016/0092-8674(92)90598-7
1853:chronic lymphocytic leukemia
1744:share a characteristic dual
996:leukocyte cell-cell adhesion
5055:Genes on human chromosome 9
3287:10.4049/jimmunol.162.5.2717
1882:(R788) in the treatment of
1795:Function during development
1707:Tyrosine-protein kinase SYK
1301:protein import into nucleus
1151:protein autophosphorylation
755:subcutaneous adipose tissue
5076:
3533:Thrombosis and Haemostasis
2621:Lawlor PB (3 March 2017).
2457:10.1016/j.phrs.2016.09.011
2310:Nature Reviews. Immunology
1867:(BCR) signaling including
1261:regulation of phagocytosis
1081:blood vessel morphogenesis
1051:animal organ morphogenesis
980:protein-containing complex
904:Toll-like receptor binding
4910:Michaelis–Menten kinetics
4409:
4395:
3803:
3796:Receptor tyrosine kinases
3789:
3642:
3507:10.1080/15216540600746377
3088:10.1042/0264-6021:3630717
2541:10.1007/s40265-014-0193-9
2085:"Mouse PubMed Reference:"
2067:"Human PubMed Reference:"
1830:mouse mammary tumor virus
1693:
1688:
1684:
1677:
1661:
1642:
1623:
1590:
1579:
1560:
1527:
1516:
1503:
1499:
1484:
1480:
1471:
1458:
1454:
1439:
1435:
1426:
1413:
1409:
1394:
1390:
1381:
1366:
1359:
1355:
1339:
829:
825:
808:
792:
783:
770:
719:
710:
673:epithelium of nasopharynx
657:
648:
618:
610:
606:
589:
576:
539:
518:
509:
505:
488:
475:
438:
415:
406:
402:
357:
354:
344:
337:
332:
81:
76:
59:
54:
49:
45:
36:
31:
4802:Diffusion-limited enzyme
3580:Medical Subject Headings
3369:10.1074/jbc.271.43.26962
3004:10.1074/jbc.272.23.14740
2845:10.1182/blood.V97.9.2633
2755:10.1074/jbc.273.52.35273
2445:Pharmacological Research
2412:10.1177/2040620716636542
2272:10.3389/fimmu.2018.01136
2221:10.3389/fimmu.2017.00789
1933:ductal carcinoma in situ
1911:Nasopharyngeal carcinoma
1752:origin and split from a
1231:receptor internalization
1116:lymph vessel development
1001:adaptive immune response
3809:Growth factor receptors
3076:The Biochemical Journal
2963:10.1074/jbc.273.15.8867
2783:The Biochemical Journal
2589:10.1074/jbc.M114.608091
2259:Frontiers in Immunology
2208:Frontiers in Immunology
1905:Epithelial malignancies
1884:immune thrombocytopenia
1655:Chr 13: 52.74 – 52.8 Mb
1026:protein phosphorylation
975:T cell receptor complex
965:B cell receptor complex
854:protein kinase activity
3473:10.1006/bbrc.2001.5788
3137:10.1084/jem.181.6.1997
3048:10.1074/jbc.M000689200
2923:10.1006/clim.2000.4955
1943:Syk has been shown to
1863:. Other inhibitors of
1711:spleen tyrosine kinase
1286:innate immune response
889:protein kinase binding
739:mesenteric lymph nodes
573:13 A5|13 27.41 cM
4895:Eadie–Hofstee diagram
4828:Allosteric regulation
3274:Journal of Immunology
3195:10.1073/pnas.92.2.359
1826:bovine leukemia virus
1804:Clinical significance
1648:Chr 9: 90.8 – 90.9 Mb
1281:inflammatory response
1186:immune system process
1121:neutrophil chemotaxis
743:stroma of bone marrow
534:Chromosome 13 (mouse)
4905:Lineweaver–Burk plot
3880:PDGF receptor family
3545:10.1160/th07-02-0156
1915:head and neck cancer
1740:. These cytoplasmic
869:transferase activity
432:Chromosome 9 (human)
77:List of PDB id codes
50:Available structures
4284:ROS receptor family
3818:EGF receptor family
3186:1995PNAS...92..359S
2911:Clinical Immunology
2664:2014PLoSO...987610B
1899:Alzheimer's disease
1842:autoimmune diseases
1041:serotonin secretion
1016:platelet activation
899:phosphatase binding
4864:Enzyme superfamily
4797:Enzyme promiscuity
2795:10.1042/BJ20021201
2627:ClinicalTrials.gov
2359:Developmental Cell
2173:10.1007/BF00189976
1889:The Syk inhibitor
1822:Epstein–Barr virus
1461:ENSMUSG00000021457
989:Biological process
928:Cellular component
914:SH2 domain binding
894:nucleotide binding
837:Molecular function
731:tibiofemoral joint
5020:
5019:
4729:
4728:
4725:
4724:
4721:
4720:
4391:
4390:
4387:
4386:
4037:
4036:
3740:
3739:
2451:(Pt A): 395–408.
1758:jawed vertebrates
1704:
1703:
1700:
1699:
1673:
1672:
1638:
1637:
1613:
1612:
1575:
1574:
1550:
1549:
1512:
1511:
1493:
1492:
1467:
1466:
1448:
1447:
1422:
1421:
1403:
1402:
1351:
1350:
821:
820:
817:
816:
779:
778:
766:
765:
704:
703:
677:bone marrow cells
602:
601:
501:
500:
328:
327:
324:
323:
60:Ortholog search:
16:(Redirected from
5067:
5060:Tyrosine kinases
5037:
5036:
5028:
4900:Hanes–Woolf plot
4843:Enzyme activator
4838:Enzyme inhibitor
4812:Enzyme catalysis
4756:
4749:
4742:
4733:
4411:
4397:
3851:Insulin receptor
3814:
3805:
3791:
3778:tyrosine kinases
3767:
3760:
3753:
3744:
3726:
3711:
3696:
3681:
3666:
3651:
3631:
3624:
3617:
3608:
3564:
3527:
3509:
3484:
3455:
3445:
3420:
3397:Immunology Today
3382:
3381:
3371:
3362:(43): 26962–70.
3347:
3341:
3340:
3330:
3306:
3300:
3299:
3289:
3265:
3259:
3258:
3248:
3224:
3218:
3217:
3207:
3197:
3165:
3159:
3158:
3148:
3131:(6): 1997–2006.
3116:
3110:
3109:
3099:
3082:(Pt 3): 717–25.
3067:
3061:
3060:
3050:
3026:
3017:
3016:
3006:
2982:
2976:
2975:
2965:
2941:
2935:
2934:
2905:
2899:
2898:
2888:
2864:
2858:
2857:
2847:
2823:
2817:
2816:
2806:
2789:(Pt 2): 687–94.
2774:
2768:
2767:
2757:
2748:(52): 35273–81.
2733:
2727:
2726:
2705:
2696:
2695:
2685:
2675:
2643:
2637:
2636:
2634:
2633:
2618:
2612:
2611:
2601:
2591:
2582:(49): 33927–44.
2567:
2561:
2560:
2524:
2518:
2517:
2507:
2475:
2469:
2468:
2440:
2434:
2433:
2423:
2391:
2385:
2384:
2374:
2350:
2344:
2343:
2333:
2301:
2295:
2294:
2284:
2274:
2250:
2244:
2243:
2233:
2223:
2199:
2193:
2192:
2156:
2150:
2149:
2113:
2107:
2106:
2099:
2093:
2092:
2081:
2075:
2074:
2063:
2057:
2047:
2036:
2026:
1738:tyrosine kinases
1732:SYK, along with
1709:, also known as
1686:
1685:
1657:
1650:
1633:
1617:
1608:
1584:
1580:RefSeq (protein)
1570:
1554:
1545:
1521:
1497:
1478:
1452:
1433:
1407:
1388:
1357:
874:integrin binding
827:
813:
804:
797:
790:
775:
747:Ileal epithelium
715:
713:Top expressed in
708:
653:
651:Top expressed in
646:
625:
608:
598:
585:
574:
559:
552:
546:
535:
523:
507:
497:
484:
473:
458:
451:
445:
434:
420:
404:
398:
349:
342:
319:
74:
68:
47:
46:
41:
29:
21:
5075:
5074:
5070:
5069:
5068:
5066:
5065:
5064:
5045:
5044:
5043:
5031:
5023:
5021:
5016:
4928:Oxidoreductases
4914:
4890:Enzyme kinetics
4878:
4874:List of enzymes
4847:
4816:
4787:Catalytic triad
4765:
4760:
4730:
4717:
4693:
4654:
4623:
4592:
4558:
4529:
4505:
4481:
4457:
4433:
4405:
4383:
4367:
4348:
4319:
4295:
4279:
4260:
4241:
4222:
4198:
4174:
4150:
4126:
4033:
4004:
3980:
3951:
3917:
3874:
3845:
3799:
3785:
3774:Protein kinases
3771:
3741:
3736:
3733:
3727:
3718:
3712:
3703:
3697:
3688:
3682:
3673:
3667:
3658:
3652:
3638:
3635:
3572:
3567:
3530:
3487:
3458:
3423:
3394:
3390:
3388:Further reading
3385:
3349:
3348:
3344:
3308:
3307:
3303:
3267:
3266:
3262:
3226:
3225:
3221:
3167:
3166:
3162:
3118:
3117:
3113:
3069:
3068:
3064:
3041:(23): 17263–8.
3028:
3027:
3020:
2997:(23): 14740–6.
2984:
2983:
2979:
2956:(15): 8867–74.
2943:
2942:
2938:
2907:
2906:
2902:
2866:
2865:
2861:
2825:
2824:
2820:
2776:
2775:
2771:
2735:
2734:
2730:
2707:
2706:
2699:
2645:
2644:
2640:
2631:
2629:
2620:
2619:
2615:
2569:
2568:
2564:
2526:
2525:
2521:
2477:
2476:
2472:
2442:
2441:
2437:
2393:
2392:
2388:
2352:
2351:
2347:
2322:10.1038/nri2765
2303:
2302:
2298:
2252:
2251:
2247:
2201:
2200:
2196:
2158:
2157:
2153:
2115:
2114:
2110:
2101:
2100:
2096:
2083:
2082:
2078:
2065:
2064:
2060:
2048:
2039:
2027:
2018:
2014:
1941:
1907:
1865:B-cell receptor
1838:
1806:
1797:
1777:T-cell receptor
1773:B-cell receptor
1754:common ancestor
1730:
1695:View/Edit Mouse
1690:View/Edit Human
1653:
1646:
1643:Location (UCSC)
1629:
1625:
1604:
1600:
1596:
1592:
1566:
1562:
1541:
1537:
1533:
1529:
1442:ENSG00000165025
1335:
1181:phosphorylation
984:
970:plasma membrane
960:early phagosome
923:
879:protein binding
844:kinase activity
809:
799:
798:
771:
762:
757:
753:
749:
745:
741:
737:
733:
729:
725:
711:
700:
695:
691:
687:
685:trabecular bone
683:
679:
675:
671:
667:
663:
649:
593:
580:
572:
562:
561:
560:
553:
533:
510:Gene location (
492:
479:
471:
461:
460:
459:
452:
430:
407:Gene location (
396:SYK - orthologs
358:
345:
338:
83:
61:
23:
22:
15:
12:
11:
5:
5073:
5071:
5063:
5062:
5057:
5047:
5046:
5042:
5041:
5018:
5017:
5015:
5014:
5001:
4988:
4975:
4962:
4949:
4936:
4922:
4920:
4916:
4915:
4913:
4912:
4907:
4902:
4897:
4892:
4886:
4884:
4880:
4879:
4877:
4876:
4871:
4866:
4861:
4855:
4853:
4852:Classification
4849:
4848:
4846:
4845:
4840:
4835:
4830:
4824:
4822:
4818:
4817:
4815:
4814:
4809:
4804:
4799:
4794:
4789:
4784:
4779:
4773:
4771:
4767:
4766:
4761:
4759:
4758:
4751:
4744:
4736:
4727:
4726:
4723:
4722:
4719:
4718:
4716:
4715:
4710:
4704:
4702:
4695:
4694:
4692:
4691:
4686:
4681:
4676:
4671:
4665:
4663:
4656:
4655:
4653:
4652:
4647:
4642:
4637:
4631:
4629:
4625:
4624:
4622:
4621:
4616:
4611:
4606:
4600:
4598:
4594:
4593:
4591:
4590:
4585:
4580:
4575:
4569:
4567:
4560:
4559:
4557:
4556:
4551:
4546:
4540:
4538:
4531:
4530:
4528:
4527:
4522:
4516:
4514:
4507:
4506:
4504:
4503:
4498:
4492:
4490:
4483:
4482:
4480:
4479:
4474:
4468:
4466:
4459:
4458:
4456:
4455:
4450:
4444:
4442:
4435:
4434:
4432:
4431:
4426:
4420:
4418:
4407:
4406:
4400:
4393:
4392:
4389:
4388:
4385:
4384:
4382:
4381:
4375:
4373:
4369:
4368:
4366:
4365:
4359:
4357:
4350:
4349:
4347:
4346:
4341:
4336:
4330:
4328:
4321:
4320:
4318:
4317:
4312:
4306:
4304:
4301:AATYK receptor
4297:
4296:
4294:
4293:
4287:
4285:
4281:
4280:
4278:
4277:
4271:
4269:
4262:
4261:
4259:
4258:
4252:
4250:
4243:
4242:
4240:
4239:
4233:
4231:
4224:
4223:
4221:
4220:
4215:
4209:
4207:
4200:
4199:
4197:
4196:
4191:
4185:
4183:
4176:
4175:
4173:
4172:
4167:
4161:
4159:
4152:
4151:
4149:
4148:
4143:
4137:
4135:
4128:
4127:
4125:
4124:
4119:
4114:
4109:
4104:
4099:
4094:
4089:
4084:
4079:
4074:
4069:
4064:
4059:
4054:
4048:
4046:
4039:
4038:
4035:
4034:
4032:
4031:
4026:
4021:
4015:
4013:
4006:
4005:
4003:
4002:
3997:
3991:
3989:
3982:
3981:
3979:
3978:
3973:
3968:
3962:
3960:
3957:VEGF receptors
3953:
3952:
3950:
3949:
3944:
3939:
3934:
3928:
3926:
3919:
3918:
3916:
3915:
3909:
3900:
3895:
3890:
3884:
3882:
3876:
3875:
3873:
3872:
3867:
3862:
3856:
3854:
3847:
3846:
3844:
3843:
3838:
3833:
3828:
3822:
3820:
3811:
3801:
3800:
3794:
3787:
3786:
3772:
3770:
3769:
3762:
3755:
3747:
3738:
3737:
3735:
3734:
3728:
3721:
3719:
3713:
3706:
3704:
3698:
3691:
3689:
3683:
3676:
3674:
3668:
3661:
3659:
3653:
3646:
3643:
3640:
3639:
3636:
3634:
3633:
3626:
3619:
3611:
3605:
3604:
3583:
3571:
3570:External links
3568:
3566:
3565:
3528:
3500:(5–6): 304–8.
3485:
3456:
3421:
3391:
3389:
3386:
3384:
3383:
3342:
3321:(6): 591–604.
3301:
3280:(5): 2717–24.
3260:
3219:
3160:
3111:
3062:
3018:
2977:
2936:
2900:
2859:
2818:
2769:
2728:
2717:(4): 193–200.
2697:
2638:
2613:
2562:
2519:
2470:
2435:
2386:
2345:
2316:(6): 387–402.
2296:
2245:
2194:
2161:Immunogenetics
2151:
2108:
2094:
2076:
2058:
2037:
2015:
2013:
2010:
2009:
2008:
2002:
1996:
1990:
1984:
1978:
1972:
1966:
1960:
1954:
1940:
1937:
1923:gastric cancer
1906:
1903:
1837:
1836:SYK inhibition
1834:
1805:
1802:
1796:
1793:
1729:
1726:
1702:
1701:
1698:
1697:
1692:
1682:
1681:
1675:
1674:
1671:
1670:
1668:
1666:
1659:
1658:
1651:
1644:
1640:
1639:
1636:
1635:
1621:
1620:
1614:
1611:
1610:
1588:
1587:
1581:
1577:
1576:
1573:
1572:
1558:
1557:
1551:
1548:
1547:
1525:
1524:
1518:
1514:
1513:
1510:
1509:
1501:
1500:
1494:
1491:
1490:
1482:
1481:
1475:
1469:
1468:
1465:
1464:
1456:
1455:
1449:
1446:
1445:
1437:
1436:
1430:
1424:
1423:
1420:
1419:
1411:
1410:
1404:
1401:
1400:
1392:
1391:
1385:
1379:
1378:
1373:
1368:
1364:
1363:
1353:
1352:
1349:
1348:
1337:
1336:
1334:
1333:
1328:
1323:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1278:
1273:
1268:
1263:
1258:
1253:
1248:
1243:
1238:
1233:
1228:
1223:
1218:
1213:
1208:
1203:
1198:
1196:beta selection
1193:
1188:
1183:
1178:
1173:
1168:
1163:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
992:
990:
986:
985:
983:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
931:
929:
925:
924:
922:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
840:
838:
834:
833:
823:
822:
819:
818:
815:
814:
806:
805:
787:
781:
780:
777:
776:
768:
767:
764:
763:
761:
760:
756:
752:
748:
744:
740:
736:
732:
728:
724:
720:
717:
716:
705:
702:
701:
699:
698:
697:jejunal mucosa
694:
690:
686:
682:
678:
674:
670:
666:
662:
658:
655:
654:
642:
641:
633:
622:
616:
615:
612:RNA expression
604:
603:
600:
599:
591:
587:
586:
578:
575:
570:
564:
563:
554:
547:
541:
537:
536:
531:
525:
524:
516:
515:
503:
502:
499:
498:
490:
486:
485:
477:
474:
469:
463:
462:
453:
446:
440:
436:
435:
428:
422:
421:
413:
412:
400:
399:
356:
352:
351:
343:
335:
334:
330:
329:
326:
325:
322:
321:
79:
78:
70:
69:
58:
52:
51:
43:
42:
34:
33:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5072:
5061:
5058:
5056:
5053:
5052:
5050:
5040:
5035:
5030:
5026:
5012:
5008:
5007:
5002:
4999:
4995:
4994:
4989:
4986:
4982:
4981:
4976:
4973:
4969:
4968:
4963:
4960:
4956:
4955:
4950:
4947:
4943:
4942:
4937:
4934:
4930:
4929:
4924:
4923:
4921:
4917:
4911:
4908:
4906:
4903:
4901:
4898:
4896:
4893:
4891:
4888:
4887:
4885:
4881:
4875:
4872:
4870:
4869:Enzyme family
4867:
4865:
4862:
4860:
4857:
4856:
4854:
4850:
4844:
4841:
4839:
4836:
4834:
4833:Cooperativity
4831:
4829:
4826:
4825:
4823:
4819:
4813:
4810:
4808:
4805:
4803:
4800:
4798:
4795:
4793:
4792:Oxyanion hole
4790:
4788:
4785:
4783:
4780:
4778:
4775:
4774:
4772:
4768:
4764:
4757:
4752:
4750:
4745:
4743:
4738:
4737:
4734:
4714:
4711:
4709:
4706:
4705:
4703:
4700:
4696:
4690:
4687:
4685:
4682:
4680:
4677:
4675:
4672:
4670:
4667:
4666:
4664:
4661:
4657:
4651:
4648:
4646:
4643:
4641:
4638:
4636:
4633:
4632:
4630:
4626:
4620:
4617:
4615:
4612:
4610:
4607:
4605:
4602:
4601:
4599:
4595:
4589:
4586:
4584:
4581:
4579:
4576:
4574:
4571:
4570:
4568:
4565:
4561:
4555:
4552:
4550:
4547:
4545:
4542:
4541:
4539:
4536:
4532:
4526:
4523:
4521:
4518:
4517:
4515:
4512:
4508:
4502:
4499:
4497:
4494:
4493:
4491:
4488:
4484:
4478:
4475:
4473:
4470:
4469:
4467:
4464:
4460:
4454:
4451:
4449:
4446:
4445:
4443:
4440:
4436:
4430:
4427:
4425:
4422:
4421:
4419:
4416:
4412:
4408:
4404:(EC 2.7.10.2)
4403:
4398:
4394:
4380:
4377:
4376:
4374:
4372:uncategorised
4370:
4364:
4361:
4360:
4358:
4355:
4351:
4345:
4342:
4340:
4337:
4335:
4332:
4331:
4329:
4326:
4322:
4316:
4313:
4311:
4308:
4307:
4305:
4302:
4298:
4292:
4289:
4288:
4286:
4282:
4276:
4273:
4272:
4270:
4267:
4266:MuSK receptor
4263:
4257:
4254:
4253:
4251:
4248:
4244:
4238:
4235:
4234:
4232:
4229:
4228:PTK7 receptor
4225:
4219:
4216:
4214:
4211:
4210:
4208:
4205:
4201:
4195:
4192:
4190:
4187:
4186:
4184:
4181:
4177:
4171:
4168:
4166:
4163:
4162:
4160:
4157:
4153:
4147:
4144:
4142:
4139:
4138:
4136:
4133:
4129:
4123:
4120:
4118:
4115:
4113:
4110:
4108:
4105:
4103:
4100:
4098:
4095:
4093:
4090:
4088:
4085:
4083:
4080:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4058:
4055:
4053:
4050:
4049:
4047:
4044:
4040:
4030:
4027:
4025:
4022:
4020:
4017:
4016:
4014:
4011:
4007:
4001:
3998:
3996:
3993:
3992:
3990:
3987:
3983:
3977:
3974:
3972:
3969:
3967:
3964:
3963:
3961:
3958:
3954:
3948:
3945:
3943:
3940:
3938:
3935:
3933:
3930:
3929:
3927:
3924:
3920:
3913:
3910:
3908:
3904:
3901:
3899:
3896:
3894:
3891:
3889:
3886:
3885:
3883:
3881:
3877:
3871:
3868:
3866:
3863:
3861:
3858:
3857:
3855:
3852:
3848:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3823:
3821:
3819:
3815:
3812:
3810:
3806:
3802:
3798:(EC 2.7.10.1)
3797:
3792:
3788:
3783:
3779:
3775:
3768:
3763:
3761:
3756:
3754:
3749:
3748:
3745:
3731:
3725:
3720:
3716:
3710:
3705:
3701:
3695:
3690:
3686:
3680:
3675:
3671:
3665:
3660:
3656:
3650:
3645:
3641:
3632:
3627:
3625:
3620:
3618:
3613:
3612:
3609:
3602:
3598:
3597:
3592:
3588:
3584:
3581:
3577:
3574:
3573:
3569:
3562:
3558:
3554:
3550:
3546:
3542:
3539:(2): 262–73.
3538:
3534:
3529:
3525:
3521:
3517:
3513:
3508:
3503:
3499:
3495:
3491:
3486:
3482:
3478:
3474:
3470:
3466:
3462:
3457:
3453:
3449:
3444:
3439:
3435:
3431:
3427:
3422:
3418:
3414:
3410:
3406:
3403:(3): 148–54.
3402:
3398:
3393:
3392:
3387:
3379:
3375:
3370:
3365:
3361:
3357:
3353:
3346:
3343:
3338:
3334:
3329:
3324:
3320:
3316:
3312:
3305:
3302:
3297:
3293:
3288:
3283:
3279:
3275:
3271:
3264:
3261:
3256:
3252:
3247:
3242:
3239:(3): 827–33.
3238:
3234:
3230:
3223:
3220:
3215:
3211:
3206:
3201:
3196:
3191:
3187:
3183:
3180:(2): 359–63.
3179:
3175:
3171:
3164:
3161:
3156:
3152:
3147:
3142:
3138:
3134:
3130:
3126:
3122:
3115:
3112:
3107:
3103:
3098:
3093:
3089:
3085:
3081:
3077:
3073:
3066:
3063:
3058:
3054:
3049:
3044:
3040:
3036:
3032:
3025:
3023:
3019:
3014:
3010:
3005:
3000:
2996:
2992:
2988:
2981:
2978:
2973:
2969:
2964:
2959:
2955:
2951:
2947:
2940:
2937:
2932:
2928:
2924:
2920:
2917:(1): 125–32.
2916:
2912:
2904:
2901:
2896:
2892:
2887:
2882:
2879:(3): 348–58.
2878:
2874:
2870:
2863:
2860:
2855:
2851:
2846:
2841:
2838:(9): 2633–9.
2837:
2833:
2829:
2822:
2819:
2814:
2810:
2805:
2800:
2796:
2792:
2788:
2784:
2780:
2773:
2770:
2765:
2761:
2756:
2751:
2747:
2743:
2739:
2732:
2729:
2724:
2720:
2716:
2712:
2704:
2702:
2698:
2693:
2689:
2684:
2679:
2674:
2669:
2665:
2661:
2658:(2): e87610.
2657:
2653:
2649:
2642:
2639:
2628:
2624:
2617:
2614:
2609:
2605:
2600:
2595:
2590:
2585:
2581:
2577:
2573:
2566:
2563:
2558:
2554:
2550:
2546:
2542:
2538:
2535:(4): 415–22.
2534:
2530:
2523:
2520:
2515:
2511:
2506:
2501:
2497:
2493:
2489:
2485:
2481:
2474:
2471:
2466:
2462:
2458:
2454:
2450:
2446:
2439:
2436:
2431:
2427:
2422:
2417:
2413:
2409:
2406:(3): 157–70.
2405:
2401:
2397:
2390:
2387:
2382:
2378:
2373:
2368:
2365:(3): 437–49.
2364:
2360:
2356:
2349:
2346:
2341:
2337:
2332:
2327:
2323:
2319:
2315:
2311:
2307:
2300:
2297:
2292:
2288:
2283:
2278:
2273:
2268:
2264:
2260:
2256:
2249:
2246:
2241:
2237:
2232:
2227:
2222:
2217:
2213:
2209:
2205:
2198:
2195:
2190:
2186:
2182:
2178:
2174:
2170:
2166:
2162:
2155:
2152:
2147:
2143:
2139:
2135:
2131:
2127:
2124:(4): 649–62.
2123:
2119:
2112:
2109:
2104:
2098:
2095:
2090:
2086:
2080:
2077:
2072:
2068:
2062:
2059:
2055:
2051:
2046:
2044:
2042:
2038:
2034:
2030:
2025:
2023:
2021:
2017:
2011:
2006:
2003:
2000:
1997:
1994:
1991:
1988:
1985:
1982:
1979:
1976:
1973:
1970:
1967:
1964:
1961:
1958:
1955:
1953:
1950:
1949:
1948:
1946:
1938:
1936:
1934:
1931:
1926:
1924:
1920:
1916:
1912:
1904:
1902:
1900:
1896:
1892:
1887:
1885:
1881:
1876:
1874:
1870:
1866:
1862:
1861:entospletinib
1858:
1854:
1850:
1845:
1843:
1835:
1833:
1831:
1827:
1823:
1819:
1815:
1811:
1803:
1801:
1794:
1792:
1790:
1786:
1782:
1778:
1774:
1770:
1766:
1761:
1759:
1755:
1751:
1747:
1743:
1739:
1735:
1727:
1725:
1723:
1720:
1716:
1712:
1708:
1696:
1691:
1687:
1683:
1680:
1676:
1669:
1667:
1664:
1660:
1656:
1652:
1649:
1645:
1641:
1634:
1632:
1628:
1622:
1618:
1615:
1609:
1607:
1603:
1599:
1595:
1589:
1585:
1582:
1578:
1571:
1569:
1565:
1559:
1555:
1552:
1546:
1544:
1540:
1536:
1532:
1526:
1522:
1519:
1517:RefSeq (mRNA)
1515:
1508:
1507:
1502:
1498:
1495:
1489:
1488:
1483:
1479:
1476:
1474:
1470:
1463:
1462:
1457:
1453:
1450:
1444:
1443:
1438:
1434:
1431:
1429:
1425:
1418:
1417:
1412:
1408:
1405:
1399:
1398:
1393:
1389:
1386:
1384:
1380:
1377:
1374:
1372:
1369:
1365:
1362:
1358:
1354:
1347:
1343:
1338:
1332:
1329:
1327:
1324:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1304:
1302:
1299:
1297:
1294:
1292:
1289:
1287:
1284:
1282:
1279:
1277:
1274:
1272:
1269:
1267:
1264:
1262:
1259:
1257:
1254:
1252:
1249:
1247:
1244:
1242:
1239:
1237:
1234:
1232:
1229:
1227:
1224:
1222:
1219:
1217:
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1197:
1194:
1192:
1189:
1187:
1184:
1182:
1179:
1177:
1174:
1172:
1169:
1167:
1164:
1162:
1161:viral process
1159:
1157:
1154:
1152:
1149:
1147:
1144:
1142:
1139:
1137:
1134:
1132:
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1112:
1109:
1107:
1104:
1102:
1099:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
993:
991:
988:
987:
981:
978:
976:
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
932:
930:
927:
926:
920:
917:
915:
912:
910:
907:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
841:
839:
836:
835:
832:
831:Gene ontology
828:
824:
812:
807:
803:
796:
791:
788:
786:
782:
774:
769:
758:
754:
750:
746:
742:
738:
734:
730:
726:
722:
721:
718:
714:
709:
706:
696:
692:
688:
684:
680:
676:
672:
668:
664:
660:
659:
656:
652:
647:
644:
643:
640:
638:
634:
632:
631:
627:
626:
623:
621:
617:
613:
609:
605:
597:
592:
588:
584:
579:
569:
565:
558:
551:
545:
538:
530:
526:
522:
517:
513:
508:
504:
496:
491:
487:
483:
478:
468:
464:
457:
450:
444:
437:
433:
427:
423:
419:
414:
410:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
361:
353:
348:
341:
336:
331:
320:
318:
314:
310:
306:
302:
298:
294:
290:
286:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
80:
75:
72:
71:
67:
64:
57:
53:
48:
44:
40:
35:
30:
27:
19:
5006:Translocases
5003:
4990:
4977:
4964:
4951:
4941:Transferases
4938:
4925:
4782:Binding site
4707:
4698:
4628:SRC-B family
4597:SRC-A family
4354:RET receptor
4325:AXL receptor
4247:RYK receptor
4204:DDR receptor
4180:ROR receptor
4156:TIE receptor
4132:LTK receptor
4043:EPH receptor
4010:Trk receptor
3986:HGF receptor
3923:FGF receptor
3729:
3714:
3699:
3684:
3669:
3654:
3594:
3536:
3532:
3497:
3493:
3467:(3): 495–8.
3464:
3460:
3433:
3429:
3400:
3396:
3359:
3355:
3345:
3318:
3314:
3304:
3277:
3273:
3263:
3236:
3232:
3222:
3177:
3173:
3163:
3128:
3124:
3114:
3079:
3075:
3065:
3038:
3034:
2994:
2990:
2980:
2953:
2949:
2939:
2914:
2910:
2903:
2876:
2872:
2862:
2835:
2831:
2821:
2786:
2782:
2772:
2745:
2741:
2731:
2714:
2710:
2655:
2651:
2641:
2630:. Retrieved
2626:
2616:
2579:
2575:
2565:
2532:
2528:
2522:
2490:(3): 331–6.
2487:
2483:
2473:
2448:
2444:
2438:
2403:
2399:
2389:
2362:
2358:
2348:
2313:
2309:
2299:
2262:
2258:
2248:
2211:
2207:
2197:
2167:(4): 300–2.
2164:
2160:
2154:
2121:
2117:
2111:
2097:
2088:
2079:
2070:
2061:
1942:
1939:Interactions
1927:
1908:
1888:
1880:fostamatinib
1877:
1857:cerdulatinib
1846:
1839:
1807:
1798:
1762:
1750:evolutionary
1731:
1718:
1710:
1706:
1705:
1627:NP_001185906
1624:
1602:NP_001167639
1598:NP_001167638
1594:NP_001128524
1591:
1564:NM_001198977
1561:
1539:NM_001174168
1535:NM_001174167
1531:NM_001135052
1528:
1504:
1485:
1459:
1440:
1414:
1395:
1375:
1370:
1046:angiogenesis
635:
628:
355:External IDs
82:
26:
4777:Active site
3637:PDB gallery
1891:nilvadipine
1785:Fc receptor
849:ATP binding
751:ankle joint
723:granulocyte
665:granulocyte
594:52,802,828
581:52,737,209
493:90,898,549
480:90,801,787
333:Identifiers
5049:Categories
4980:Isomerases
4954:Hydrolases
4821:Regulation
3576:Syk+kinase
3494:IUBMB Life
3436:(1): 1–3.
2632:2017-04-02
2056:, May 2017
2035:, May 2017
2012:References
1873:idelalisib
1746:SH2 domain
689:lymph node
639:(ortholog)
376:HomoloGene
18:SYK (gene)
4859:EC number
1869:ibrutinib
1789:integrins
1631:NP_035648
1606:NP_003168
1568:NM_011518
1543:NM_003177
1361:Orthologs
935:cytoplasm
384:GeneCards
4883:Kinetics
4807:Cofactor
4770:Activity
3561:41094726
3553:17721605
3524:41684033
3516:16754322
3481:11676469
3452:10933389
3430:Immunity
3417:10689303
3315:Immunity
3296:10072516
3106:11964172
3057:10747947
2931:11141335
2854:11313252
2813:12435267
2723:11331248
2692:24523870
2652:PLOS ONE
2608:25331948
2557:24168330
2549:24610702
2514:27252232
2465:27641927
2430:27247756
2381:20230750
2340:20467426
2291:29881386
2265:: 1136.
2240:28736554
2189:33774157
2146:54326428
2052:–
2031:–
1952:Cbl gene
1945:interact
1849:lymphoma
1728:Function
1713:, is an
1679:Wikidata
1340:Sources:
945:membrane
681:appendix
661:monocyte
5039:Biology
4993:Ligases
4763:Enzymes
3784:2.7.10)
3601:PDBe-KB
3591:UniProt
3378:8900182
3337:8986718
3255:9342235
3214:7831290
3182:Bibcode
3155:7539035
3146:2192070
3097:1222524
3013:9169439
2972:9535867
2895:9268059
2804:1223185
2764:9857068
2683:3921124
2660:Bibcode
2599:4256331
2505:5161010
2421:4872176
2331:4782221
2282:5978004
2231:5500614
2214:: 789.
2181:8082894
2138:1423621
2054:Ensembl
2033:Ensembl
1769:T cells
1756:in the
1473:UniProt
1428:Ensembl
1367:Species
1346:QuickGO
955:nucleus
940:cytosol
614:pattern
340:Aliases
5025:Portal
4967:Lyases
4701:family
4662:family
4566:family
4537:family
4513:family
4489:family
4465:family
4441:family
4417:family
4356:family
4327:family
4315:AATYK2
4303:family
4268:family
4249:family
4230:family
4206:family
4182:family
4158:family
4134:family
4045:family
4012:family
3988:family
3976:VEGFR3
3971:VEGFR2
3966:VEGFR1
3959:family
3925:family
3912:PDGFRB
3907:PDGFRA
3853:family
3596:P43405
3582:(MeSH)
3559:
3551:
3522:
3514:
3479:
3450:
3415:
3376:
3335:
3294:
3253:
3212:
3202:
3153:
3143:
3104:
3094:
3055:
3011:
2970:
2929:
2893:
2852:
2811:
2801:
2762:
2721:
2690:
2680:
2606:
2596:
2555:
2547:
2512:
2502:
2463:
2428:
2418:
2379:
2338:
2328:
2289:
2279:
2238:
2228:
2187:
2179:
2144:
2136:
1963:FCGR2A
1947:with:
1930:breast
1919:breast
1828:, and
1787:, and
1715:enzyme
1665:search
1663:PubMed
1506:P48025
1487:P43405
1383:Entrez
785:BioGPS
727:spleen
693:spleen
472:9q22.2
364:600085
4919:Types
4713:ZAP70
4379:STYK1
4344:TYRO3
4310:AATYK
4117:EPHB6
4112:EPHB5
4107:EPHB4
4102:EPHB3
4097:EPHB2
4092:EPHB1
4087:EPHA8
4082:EPHA7
4077:EPHA6
4072:EPHA5
4067:EPHA4
4062:EPHA3
4057:EPHA2
4052:EPHA1
4029:NTRK3
4024:NTRK2
4019:NTRK1
3947:FGFR4
3942:FGFR3
3937:FGFR2
3932:FGFR1
3903:PDGFR
3888:CSF1R
3870:INSRR
3860:IGF1R
3841:ERBB4
3836:ERBB3
3831:ERBB2
3557:S2CID
3520:S2CID
3205:42739
2832:Blood
2553:S2CID
2529:Drugs
2484:Blood
2185:S2CID
2142:S2CID
2001:, and
1999:PTPN6
1734:ZAP70
1416:20963
1376:Mouse
1371:Human
1342:Amigo
735:blood
669:blood
637:Mouse
630:Human
577:Start
512:Mouse
476:Start
409:Human
372:99515
5011:list
5004:EC7
4998:list
4991:EC6
4985:list
4978:EC5
4972:list
4965:EC4
4959:list
4952:EC3
4946:list
4939:EC2
4933:list
4926:EC1
4619:YES1
4588:TYK2
4583:JAK3
4578:JAK2
4573:JAK1
4554:SRMS
4501:PYK2
4477:MATK
4453:TNK1
4448:ACK1
4424:ABL1
4291:ROS1
4275:MUSK
4237:PTK7
4218:DDR2
4213:DDR1
4194:ROR2
4189:ROR1
4122:EPHX
3893:FLT3
3865:INSR
3826:EGFR
3730:1xbc
3715:1xbb
3700:1xba
3685:1csz
3670:1csy
3655:1a81
3589:for
3549:PMID
3512:PMID
3477:PMID
3448:PMID
3413:PMID
3374:PMID
3333:PMID
3292:PMID
3251:PMID
3210:PMID
3151:PMID
3102:PMID
3053:PMID
3009:PMID
2968:PMID
2927:PMID
2891:PMID
2877:1357
2850:PMID
2809:PMID
2760:PMID
2719:PMID
2688:PMID
2604:PMID
2545:PMID
2510:PMID
2461:PMID
2426:PMID
2377:PMID
2336:PMID
2287:PMID
2236:PMID
2177:PMID
2134:PMID
2118:Cell
2005:VAV1
1993:PTK2
1975:Grb2
1957:CRKL
1921:and
1913:and
1859:and
1851:and
1812:and
1781:CD74
1775:and
1767:and
1722:gene
1397:6850
620:Bgee
568:Band
529:Chr.
467:Band
426:Chr.
380:2390
360:OMIM
317:5GHV
313:4XG9
309:4YJS
305:4YJU
301:4YJT
297:4WNM
293:4YJO
289:4YJV
285:5C26
281:4XG4
277:4RSS
273:5C27
269:4YJP
265:4YJR
261:4XG7
257:4XG8
253:4XG3
249:4XG2
245:4XG6
241:5CY3
237:5CXZ
233:5CXH
229:4RX9
225:4RX8
221:4RX7
217:4PX6
213:4PV0
209:4PUZ
205:4I0T
201:4I0S
197:4I0R
193:4GFG
189:4FZ7
185:4FZ6
181:4FYO
177:4FYN
173:4FL3
169:4FL2
165:4FL1
161:4F4P
157:4DFN
153:4DFL
149:3VF9
145:3VF8
141:3TUD
137:3TUC
133:3TUB
129:3SRV
125:3FQS
121:3FQH
117:3FQE
113:3EMG
109:3BUW
105:1XBC
101:1XBB
97:1XBA
93:1CSZ
89:1CSY
85:1A81
66:RCSB
63:PDBe
4708:SYK
4699:SYK
4689:TXK
4684:ITK
4679:BTK
4674:BMX
4669:TEC
4660:TEC
4650:LYN
4645:LCK
4640:HCK
4635:BLK
4614:FYN
4609:FGR
4604:SRC
4564:JAK
4549:BRK
4544:FRK
4535:FRK
4525:FER
4520:FES
4511:FES
4496:FAK
4487:FAK
4472:CSK
4463:CSK
4439:ACK
4429:ARG
4415:ABL
4363:RET
4339:MER
4334:AXL
4256:RYK
4170:TEK
4165:TIE
4146:ALK
4141:LTK
4000:RON
3995:MET
3898:KIT
3587:PDB
3541:doi
3502:doi
3469:doi
3465:288
3438:doi
3405:doi
3364:doi
3360:271
3323:doi
3282:doi
3278:162
3241:doi
3237:248
3200:PMC
3190:doi
3141:PMC
3133:doi
3129:181
3092:PMC
3084:doi
3080:363
3043:doi
3039:275
2999:doi
2995:272
2958:doi
2954:273
2919:doi
2881:doi
2840:doi
2799:PMC
2791:doi
2787:370
2750:doi
2746:273
2678:PMC
2668:doi
2594:PMC
2584:doi
2580:289
2537:doi
2500:PMC
2492:doi
2488:128
2453:doi
2449:113
2416:PMC
2408:doi
2367:doi
2326:PMC
2318:doi
2277:PMC
2267:doi
2226:PMC
2216:doi
2169:doi
2126:doi
1987:LYN
1981:Lck
1969:FYN
1895:Tau
1814:Tel
1810:Itk
1719:SYK
590:End
489:End
392:OMA
388:SYK
368:MGI
347:SYK
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