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incrementally higher doses of salicylates, usually aspirin, under medical supervision, until either symptoms appear or the likelihood of symptoms appearing is ruled out. This only pertains to short-term symptoms such as digestive, respiratory, and skin itching, rather than slower-developing symptoms such as nasal polyps.
428:
There is no laboratory test for salicylate sensitivity. Typically testing is done by an "elimination challenge," to see if symptoms improve, or "provocative challenge," which intends to induce a controlled reaction as a means of confirming diagnosis. During provocative challenge, the person is given
441:. The Feingold Diet removes artificial colors and preservatives and salicylates, whereas the Failsafe Diet removes salicylates, as well as amines and glutamates. The range of foods that have no salicylate content is very limited, and consequently salicylate-free diets are very restricted.
1026:
502:. However, it is possible for aspirin to trigger non-allergic hypersensitivity reactions. About 5–10% of asthmatics have aspirin hypersensitivity, but dietary salicylates have been shown not to contribute to this. The reactions in
359:
and preservatives. Both natural and synthetic salicylates can cause health problems in anyone when consumed in large doses. But for those who are salicylate intolerant, even small doses of salicylate can cause adverse reactions.
639:
Kim SH, Ye YM, Hur GY, Lee SK, Sampson AP, Lee HY, Park HS (September 2007). "CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients".
550:
506:(Samter's triad) are due to inhibition of the COX-1 enzyme by aspirin, as well as other NSAIDs that are not salicylates. Dietary salicylates have not been shown to significantly affect COX-1.
1083:
844:
Narayanankutty A, Reséndiz-Hernández JM, Falfán-Valencia R, Teran LM (May 2013). "Biochemical pathogenesis of aspirin exacerbated respiratory disease (AERD)". Review.
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Salicylate sensitivity is noted to be more common in those who also have asthma, 2-22% of people with asthma have a likelihood of also having the intolerance.
879:
Jang AS, Park JS, Park SW, Kim DJ, Uh ST, Seo KH, Kim YH, Park HS, Park CS (November 2008). "Obesity in aspirin-tolerant and aspirin-intolerant asthmatics".
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of salicylates. Salicylate overdose can occur in people without salicylate sensitivity, and can be deadly if untreated. For more information, see
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467:, which has a long history. Aspirin intolerance was widely known by 1975, when the understanding began to emerge that it is an
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Patriarca G, Venuti A, Schiavino D, Fais G (1976). "Intolerance to aspirin: clinical and immunological studies".
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is ingested. People with salicylate intolerance are unable to consume a normal amount of salicylate without
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924:"The prevalence of Samter's triad in patients undergoing functional endoscopic sinus surgery"
676:"Sensitivity to food additives, vaso-active amines and salicylates: a review of the evidence"
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Salicylate sensitivity can be treated with the use of low-salicylate diets, such as the
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573:"Salicylate Intolerance: Pathophysiology, Clinical Spectrum, Diagnosis and Treatment"
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420:(AERD, Samter's Triad), which is not believed to be caused by dietary salicylates.
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104: in this article. Unsourced material may be challenged and removed.
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Salicylates are derivatives of salicylic acid that occur naturally in
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is generally non-toxic metal, but in large doses it can lead to
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797:"What do we know about the genetics of aspirin intolerance?"
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Skypala IJ, Williams M, Reeves L, Meyer R, Venter C (2015).
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is one form of treatment used in aspirin-intolerant asthma.
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Casterline CL (November 1975). "Intolerance to aspirin".
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The most common symptoms of salicylate sensitivity are:
1051:"Salicylate Sensitivity Forums and Food/Product Guides"
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AERD refers to NSAID sensitivity in conjunction with
202:. Please help to ensure that disputed statements are
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762:Zeitschrift für Immunitatsforschung. Immunobiology
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801:Journal of Clinical Pharmacy and Therapeutics
416:Asthma and nasal polyps are also symptoms of
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968:Parmet S, Lynm C, Glass RM (December 2004).
795:Palikhe NS, Kim SH, Park HS (October 2008).
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312:, which occurs when an individual takes an
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240:Learn how and when to remove this message
222:Learn how and when to remove this message
164:Learn how and when to remove this message
970:"JAMA patient page. Aspirin sensitivity"
351:. Salicylates can also be found in many
198:Relevant discussion may be found on the
92:Relevant discussion may be found on the
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527:Aspirin-exacerbated respiratory disease
418:aspirin-exacerbated respiratory disease
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2015:
479:Salicylate intolerance is a form of
308:Salicylate sensitivity differs from
102:adding citations to reliable sources
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297:that occurs when a usual amount of
922:Kim JE, Kountakis SE (July 2007).
680:Clinical and Translational Allergy
577:Deutsches Ärzteblatt International
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858:10.1016/j.clinbiochem.2012.12.005
44:This article has multiple issues.
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2014:
2003:
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893:10.1111/j.1440-1843.2008.01358.x
814:10.1111/j.1365-2710.2008.00961.x
532:NSAID hypersensitivity reactions
463:An important salicylate drug is
391:and other breathing difficulties
335:, protecting the plants against
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33:
928:Ear, Nose, & Throat Journal
622:"Feingold Diet / Failsafe Diet"
85:needs additional citations for
52:or discuss these issues on the
1:
774:10.1016/s0300-872x(76)80024-8
571:Hanns-Wolf Baenkler (2008).
556:Dorland's Medical Dictionary
490:Salicylate sensitivity is a
372:Intestinal inflammation or
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1755:Arthropod bites and stings
1374:Nitrogen dioxide poisoning
941:10.1177/014556130708600715
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1514:Tricyclic antidepressants
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1055:SalicylateSensitivity.com
735:American Family Physician
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653:10.2217/14622416.8.9.1143
589:10.3238/arztebl.2008.0137
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113:"Salicylate sensitivity"
1953:List of types of poison
1509:Serotonergic substances
327:and serve as a natural
1241:Other non-toxic metals
291:Salicylate sensitivity
267:Salicylate intolerance
258:Salicylate sensitivity
18:Salicylate intolerance
1621:Ichthyoallyeinotoxism
846:Clinical Biochemistry
494:reaction, not a true
469:adverse drug reaction
191:factual accuracy is
98:improve this article
2059:Metabolic disorders
1991:foodborne illnesses
1948:Lists of poisonings
1631:Shellfish poisoning
1339:Aluminium phosphide
1943:EPA list of hazard
1725:Alpha-Bungarotoxin
1469:Anticholinesterase
471:, not an allergy.
394:Polyps with asthma
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16:(Redirected from
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1402:Ethylene glycol
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828:
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1802:Latrodectism
1793:spider venom
1616:Haff disease
1537:Dipyridamole
1479:Barbiturates
1389:
1151:Toxic metals
1054:
1025:
980:(24): 3098.
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551:"salicylism"
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511:nasal polyps
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451:Epidemiology
443:
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411:nasal polyps
378:Itchy skin,
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333:preservative
331:hormone and
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87:verification
84:
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46:Please help
43:
26:
2033:WikiProject
1846:Fish toxins
1807:Loxoscelism
1720:Snake venom
1692:Physalaemin
1664:vertebrates
1504:Paracetamol
881:Respirology
475:Terminology
445:Montelukast
353:medications
263:Other names
2053:Categories
1981:including
1938:Antibiotic
1866:Strychnine
1836:Cinchonism
1798:Latrotoxin
1747:Arthropods
1735:Batroxobin
1646:Neurotoxic
1641:Diarrhetic
1591:Biological
1334:Pesticides
1326:Phosphorus
1262:Metalloids
538:References
498:-mediated
398:Angioedema
310:salicylism
299:salicylate
124:newspapers
49:improve it
1958:Pollution
1898:Cnidocyte
1851:Lathyrism
1764:Bee venom
1760:Bee sting
1704:Coturnism
1687:Bufotenin
1672:Amphibian
1651:Paralytic
1626:Scombroid
1611:Ciguatera
1569:Vitamin E
1564:Vitamin D
1559:Vitamin A
1280:Nonmetals
1227:Manganese
1159:Beryllium
1133:Inorganic
1095:Poisoning
702:2045-7022
433:Treatment
424:Diagnosis
407:sinusitis
212:June 2017
200:talk page
94:talk page
55:talk page
2009:Category
1861:Mushroom
1841:Ergotism
1826: /
1800: /
1774:Melittin
1762: /
1718: /
1682:Bombesin
1601: /
1578:syndrome
1407:Methanol
1369:Nicotine
1356:Nitrogen
1303:Fluoride
1298:Chlorine
1293:Selenium
1207:Chromium
1184:Thallium
1105:Overdose
1100:Toxicity
996:15613676
950:17702319
909:26399839
901:18699807
866:23246457
831:22584486
823:18834360
720:26468368
661:17924829
607:19633779
521:See also
403:Rhinitis
374:diarrhea
364:Symptoms
357:perfumes
349:bacteria
337:diseases
314:overdose
193:disputed
2069:Aspirin
2021:Commons
1977:argyria
1886:Stinger
1856:Locoism
1636:Amnesic
1603:Seafood
1532:Digoxin
1499:Opioids
1494:Lithium
1489:Cocaine
1474:Aspirin
1464:Alcohol
1456:Nervous
1424:Toluene
1397:Ethanol
1391:alcohol
1364:Cyanide
1317:Organic
1270:Arsenic
1174:Mercury
1164:Cadmium
1123:History
747:1199905
711:4604636
598:2696737
500:allergy
465:aspirin
459:History
341:insects
293:is any
138:scholar
1987:toxins
1983:venoms
1973:Silver
1824:Plants
1769:Apamin
1730:Ancrod
1716:Snakes
1711:Mammal
1662:Other
1419:Oxygen
1248:Silver
1217:Copper
1212:Cobalt
1179:Nickel
1142:Metals
1118:Poison
1036:E935.3
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782:936715
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515:asthma
483:or of
389:Asthma
384:rashes
329:immune
325:plants
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126:
119:
111:
1891:plant
1828:Fungi
1699:Birds
905:S2CID
827:S2CID
380:hives
345:fungi
145:JSTOR
131:books
1884:and
1882:Bite
1599:Fish
1232:Zinc
1222:Iron
1169:Lead
1031:9-CM
992:PMID
974:JAMA
946:PMID
897:PMID
862:PMID
819:PMID
778:PMID
743:PMID
716:PMID
698:ISSN
657:PMID
603:PMID
513:and
504:AERD
117:news
1383:CHO
1189:Tin
1027:ICD
982:doi
978:292
936:doi
889:doi
854:doi
809:doi
770:doi
766:151
706:PMC
688:doi
649:doi
593:PMC
585:doi
581:105
553:at
496:IgE
382:or
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