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incrementally higher doses of salicylates, usually aspirin, under medical supervision, until either symptoms appear or the likelihood of symptoms appearing is ruled out. This only pertains to short-term symptoms such as digestive, respiratory, and skin itching, rather than slower-developing symptoms such as nasal polyps.
417:
There is no laboratory test for salicylate sensitivity. Typically testing is done by an "elimination challenge," to see if symptoms improve, or "provocative challenge," which intends to induce a controlled reaction as a means of confirming diagnosis. During provocative challenge, the person is given
430:. The Feingold Diet removes artificial colors and preservatives and salicylates, whereas the Failsafe Diet removes salicylates, as well as amines and glutamates. The range of foods that have no salicylate content is very limited, and consequently salicylate-free diets are very restricted.
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491:. However, it is possible for aspirin to trigger non-allergic hypersensitivity reactions. About 5–10% of asthmatics have aspirin hypersensitivity, but dietary salicylates have been shown not to contribute to this. The reactions in
348:
and preservatives. Both natural and synthetic salicylates can cause health problems in anyone when consumed in large doses. But for those who are salicylate intolerant, even small doses of salicylate can cause adverse reactions.
628:
Kim SH, Ye YM, Hur GY, Lee SK, Sampson AP, Lee HY, Park HS (September 2007). "CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients".
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495:(Samter's triad) are due to inhibition of the COX-1 enzyme by aspirin, as well as other NSAIDs that are not salicylates. Dietary salicylates have not been shown to significantly affect COX-1.
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Narayanankutty A, Reséndiz-Hernández JM, Falfán-Valencia R, Teran LM (May 2013). "Biochemical pathogenesis of aspirin exacerbated respiratory disease (AERD)". Review.
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Salicylate sensitivity is noted to be more common in those who also have asthma, 2-22% of people with asthma have a likelihood of also having the intolerance.
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Jang AS, Park JS, Park SW, Kim DJ, Uh ST, Seo KH, Kim YH, Park HS, Park CS (November 2008). "Obesity in aspirin-tolerant and aspirin-intolerant asthmatics".
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of salicylates. Salicylate overdose can occur in people without salicylate sensitivity, and can be deadly if untreated. For more information, see
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Patriarca G, Venuti A, Schiavino D, Fais G (1976). "Intolerance to aspirin: clinical and immunological studies".
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is ingested. People with salicylate intolerance are unable to consume a normal amount of salicylate without
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913:"The prevalence of Samter's triad in patients undergoing functional endoscopic sinus surgery"
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Salicylate sensitivity can be treated with the use of low-salicylate diets, such as the
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562:"Salicylate Intolerance: Pathophysiology, Clinical Spectrum, Diagnosis and Treatment"
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409:(AERD, Samter's Triad), which is not believed to be caused by dietary salicylates.
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93: in this article. Unsourced material may be challenged and removed.
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Salicylates are derivatives of salicylic acid that occur naturally in
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is generally non-toxic metal, but in large doses it can lead to
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786:"What do we know about the genetics of aspirin intolerance?"
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Skypala IJ, Williams M, Reeves L, Meyer R, Venter C (2015).
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is one form of treatment used in aspirin-intolerant asthma.
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Casterline CL (November 1975). "Intolerance to aspirin".
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The most common symptoms of salicylate sensitivity are:
1040:"Salicylate Sensitivity Forums and Food/Product Guides"
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AERD refers to NSAID sensitivity in conjunction with
191:. Please help to ensure that disputed statements are
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751:Zeitschrift für Immunitatsforschung. Immunobiology
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790:Journal of Clinical Pharmacy and Therapeutics
405:Asthma and nasal polyps are also symptoms of
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957:Parmet S, Lynm C, Glass RM (December 2004).
784:Palikhe NS, Kim SH, Park HS (October 2008).
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301:, which occurs when an individual takes an
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211:Learn how and when to remove this message
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959:"JAMA patient page. Aspirin sensitivity"
340:. Salicylates can also be found in many
187:Relevant discussion may be found on the
81:Relevant discussion may be found on the
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516:Aspirin-exacerbated respiratory disease
407:aspirin-exacerbated respiratory disease
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2004:
468:Salicylate intolerance is a form of
297:Salicylate sensitivity differs from
91:adding citations to reliable sources
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286:that occurs when a usual amount of
911:Kim JE, Kountakis SE (July 2007).
669:Clinical and Translational Allergy
566:Deutsches Ärzteblatt International
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847:10.1016/j.clinbiochem.2012.12.005
33:This article has multiple issues.
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521:NSAID hypersensitivity reactions
452:An important salicylate drug is
380:and other breathing difficulties
324:, protecting the plants against
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917:Ear, Nose, & Throat Journal
611:"Feingold Diet / Failsafe Diet"
74:needs additional citations for
41:or discuss these issues on the
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763:10.1016/s0300-872x(76)80024-8
560:Hanns-Wolf Baenkler (2008).
545:Dorland's Medical Dictionary
479:Salicylate sensitivity is a
361:Intestinal inflammation or
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1744:Arthropod bites and stings
1363:Nitrogen dioxide poisoning
930:10.1177/014556130708600715
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102:"Salicylate sensitivity"
1942:List of types of poison
1498:Serotonergic substances
316:and serve as a natural
1230:Other non-toxic metals
280:Salicylate sensitivity
256:Salicylate intolerance
247:Salicylate sensitivity
1610:Ichthyoallyeinotoxism
835:Clinical Biochemistry
483:reaction, not a true
458:adverse drug reaction
180:factual accuracy is
87:improve this article
2048:Metabolic disorders
1980:foodborne illnesses
1937:Lists of poisonings
1620:Shellfish poisoning
1328:Aluminium phosphide
1932:EPA list of hazard
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914:
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876:(7): 1034–8.
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848:
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840:
836:
829:
826:
821:
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796:(5): 465–72.
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772:
768:
764:
760:
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745:
742:
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733:
730:(5): 119–22.
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143:December 2010
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104: –
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72:This article
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2020:
2008:
1996:
1791:Latrodectism
1782:spider venom
1605:Haff disease
1526:Dipyridamole
1468:Barbiturates
1378:
1140:Toxic metals
1043:
1014:
969:(24): 3098.
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923:(7): 396–9.
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609:Matthews J.
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540:"salicylism"
535:
500:nasal polyps
497:
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467:
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440:Epidemiology
432:
425:
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404:
400:nasal polyps
367:Itchy skin,
356:
322:preservative
320:hormone and
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76:verification
73:
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36:
35:Please help
32:
15:
2022:WikiProject
1835:Fish toxins
1796:Loxoscelism
1709:Snake venom
1681:Physalaemin
1653:vertebrates
1493:Paracetamol
870:Respirology
464:Terminology
434:Montelukast
342:medications
252:Other names
2042:Categories
1970:including
1927:Antibiotic
1855:Strychnine
1825:Cinchonism
1787:Latrotoxin
1736:Arthropods
1724:Batroxobin
1635:Neurotoxic
1630:Diarrhetic
1580:Biological
1323:Pesticides
1315:Phosphorus
1251:Metalloids
527:References
487:-mediated
387:Angioedema
299:salicylism
288:salicylate
113:newspapers
38:improve it
1947:Pollution
1887:Cnidocyte
1840:Lathyrism
1753:Bee venom
1749:Bee sting
1693:Coturnism
1676:Bufotenin
1661:Amphibian
1640:Paralytic
1615:Scombroid
1600:Ciguatera
1558:Vitamin E
1553:Vitamin D
1548:Vitamin A
1269:Nonmetals
1216:Manganese
1148:Beryllium
1122:Inorganic
1084:Poisoning
691:2045-7022
422:Treatment
413:Diagnosis
396:sinusitis
201:June 2017
189:talk page
83:talk page
44:talk page
1998:Category
1850:Mushroom
1830:Ergotism
1815: /
1789: /
1763:Melittin
1751: /
1707: /
1671:Bombesin
1590: /
1567:syndrome
1396:Methanol
1358:Nicotine
1345:Nitrogen
1292:Fluoride
1287:Chlorine
1282:Selenium
1196:Chromium
1173:Thallium
1094:Overdose
1089:Toxicity
985:15613676
939:17702319
898:26399839
890:18699807
855:23246457
820:22584486
812:18834360
709:26468368
650:17924829
596:19633779
510:See also
392:Rhinitis
363:diarrhea
353:Symptoms
346:perfumes
338:bacteria
326:diseases
303:overdose
182:disputed
2058:Aspirin
2010:Commons
1966:argyria
1875:Stinger
1845:Locoism
1625:Amnesic
1592:Seafood
1521:Digoxin
1488:Opioids
1483:Lithium
1478:Cocaine
1463:Aspirin
1453:Alcohol
1445:Nervous
1413:Toluene
1386:Ethanol
1380:alcohol
1353:Cyanide
1306:Organic
1259:Arsenic
1163:Mercury
1153:Cadmium
1112:History
736:1199905
700:4604636
587:2696737
489:allergy
454:aspirin
448:History
330:insects
282:is any
127:scholar
1976:toxins
1972:venoms
1962:Silver
1813:Plants
1758:Apamin
1719:Ancrod
1705:Snakes
1700:Mammal
1651:Other
1408:Oxygen
1237:Silver
1206:Copper
1201:Cobalt
1168:Nickel
1131:Metals
1107:Poison
1025:E935.3
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771:936715
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504:asthma
472:or of
378:Asthma
373:rashes
318:immune
314:plants
129:
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115:
108:
100:
1880:plant
1817:Fungi
1688:Birds
894:S2CID
816:S2CID
369:hives
334:fungi
134:JSTOR
120:books
1873:and
1871:Bite
1588:Fish
1221:Zinc
1211:Iron
1158:Lead
1020:9-CM
981:PMID
963:JAMA
935:PMID
886:PMID
851:PMID
808:PMID
767:PMID
732:PMID
705:PMID
687:ISSN
646:PMID
592:PMID
502:and
493:AERD
106:news
1372:CHO
1178:Tin
1016:ICD
971:doi
967:292
925:doi
878:doi
843:doi
798:doi
759:doi
755:151
695:PMC
677:doi
638:doi
582:PMC
574:doi
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485:IgE
371:or
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