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Staphylococcal scalded skin syndrome

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from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal
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Children with SSSS may exhibit fussiness or irritability, tiredness, fever, redness of the skin, easily broken fluid-filled blisters that leave an area of moist, tender, painful skin, and large sheets of the top layer of skin that easily peel away.
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In 1885, Nil Filatow, and in 1894, Clement Dukes, described an exanthematous disease which they thought to be a form of rubella, but in 1900, Dukes identified it to be a separate entity which came to be known by the names
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The clinical features were first described in 1878 by Baron Gottfried Ritter von Rittershain, who observed 297 cases among children in a single Czechoslovakian children's home over a 10-year period.
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The prognosis of SSSS in children is excellent, with complete resolution within 10 days of treatment, and without significant scarring. However, SSSS must be differentiated carefully from
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The mainstay of treatment for SSSS is supportive care along with eradication of the primary infection. Conservative measures include rehydration, antipyretics (e.g.,
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caused by staphylococcal exotoxin after Keith Powell proposed equating it with the condition currently known as staphylococcal scalded skin syndrome in 1979.
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Powell, KR (January 1979). "Filatow-Dukes' disease. Epidermolytic toxin-producing staphylococci as the etiologic agent of the fourth childhood exanthem".
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The disease presents with the widespread formation of fluid-filled blisters that are thin walled and easily ruptured, and the patient can be positive for
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Dukes, Clement (30 June 1900). "On the confusion of two different diseases under the name of rubella (rose-rash)".
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separation). SSSS may be difficult to distinguish from toxic epidermal necrolysis and pustular psoriasis.
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The condition is most common in children under 6 years, but can be seen in adults who are
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might be present. Perioral crusting and fissuring are seen early in the course. Unlike
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layers together, similar to the pathophysiology of the autoimmune skin disease,
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SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of
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Weisse, Martin E (31 December 2000). "The fourth disease, 1900-2000".
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Mockenhaupt M, Idzko M, Grosber M, Schöpf E, Norgauer J (April 2005).
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and cause detachment within the epidermal layer, by breaking down the
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Morens, David M; Katz, Alan R; Melish, Marian E (31 May 2001).
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is sometimes also used because of its inhibition of exotoxins.
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List of conditions caused by problems with junctional proteins
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An infant with Staphylococcal scalded skin syndrome
37: 32: 41:Pemphigus neonatorum, Ritter's disease, localized 109:, often involving the face, diaper, and other 1584: 749: 8: 168:. These exotoxins are proteases that cleave 307:Rapini RP, Bolognia JL, Jorizzo JL (2007). 2576:Recurrent toxin-mediated perineal erythema 1995: 1986: 1862:Mycobacterium avium–intracellulare complex 1786: 1621: 1612: 1591: 1577: 1569: 1484: 1337: 1321: 1147: 1136: 932: 833: 824: 813: 798: 756: 742: 734: 609: 49: 29: 1671:Cutaneous group B streptococcal infection 392: 488:American Journal of Diseases of Children 217:should be administered. Most strains of 1033:Cutaneous Streptococcus iniae infection 299: 2612:Bacterium-related cutaneous conditions 333:"Staphylococcal Scalded Skin Syndrome" 1895:Rapid growing mycobacterium infection 521:Melish, ME; Glasgow, LA (June 1971). 121:, SSSS spares the mucous membranes. 7: 2074:Human granulocytotropic anaplasmosis 1636:Staphylococcal scalded skin syndrome 1167:Staphylococcal scalded skin syndrome 562:"The fourth disease, 1900–1881, RIP" 500:10.1001/archpedi.1979.02130010094020 77:Staphylococcal scalded skin syndrome 33:Staphylococcal scalded skin syndrome 2524:Chronic undermining burrowing ulcer 25: 2482:Superficial pustular folliculitis 2079:Human monocytotropic ehrlichiosis 1403:Clostridial necrotizing enteritis 156:) A and B, which are released by 1890:Primary inoculation tuberculosis 394:10.1111/j.0022-202X.2005.23642.x 2388:Gram-negative toe web infection 1964:Group JK corynebacterium sepsis 1008:Group B streptococcal infection 956:Group A streptococcal infection 2129:Ehrlichiosis ewingii infection 1951:Cutaneous diphtheria infection 1905:Tuberculosis cutis orificialis 1816:Borderline tuberculoid leprosy 1806:Borderline lepromatous leprosy 1: 2153:Primary gonococcal dermatitis 2099:Flinders Island spotted fever 578:10.1016/S0140-6736(00)05151-5 539:10.1016/S0022-3476(71)80425-0 457:10.1016/S0140-6736(00)03623-0 430:10.1016/S0140-6736(00)65681-7 2617:Syndromes caused by microbes 2541:Blistering distal dactylitis 2069:Rocky Mountain spotted fever 1957:Arcanobacterium haemolyticum 1910:Tuberculosis verrucosa cutis 1694:Chronic recurrent erysipelas 1546:Erysipelothrix rhusiopathiae 363:Dorland's Medical Dictionary 283:List of cutaneous conditions 148:is induced by epidermolytic 2561:Blastomycosis-like pyoderma 2182:Chromobacteriosis infection 2094:Mediterranean spotted fever 172:, which normally holds the 2633: 2581:Tick-borne lymphadenopathy 2383:Gram-negative folliculitis 251:toxic epidermal necrolysis 119:toxic epidermal necrolysis 113:areas. Extensive areas of 1885:Papulonecrotic tuberculid 1870:Mycobacterium haemophilum 961:Streptococcal pharyngitis 527:The Journal of Pediatrics 309:Dermatology: 2-Volume Set 57: 48: 2378:Lymphogranuloma venereum 2084:Flea-borne spotted fever 2057:Rickettsia aeschlimannii 2051:American tick bite fever 1761:Erysipeloid of Rosenbach 1676:Streptococcal intertrigo 1441:Pseudomembranous colitis 1435:Clostridioides difficile 237:is typically indicated. 221:implicated in SSSS have 2509:Trichomycosis axillaris 2046:African tick bite fever 2021:North Asian tick typhus 1941:Cutaneous actinomycosis 1392:Clostridium perfringens 1103:Urinary tract infection 2221:Haemophilus influenzae 2165:Pasteurella hemolytica 2089:Japanese spotted fever 2041:Bacillary angiomatosis 2031:Flying squirrel typhus 2026:Queensland tick typhus 1915:Tuberculous cellulitis 1878:Mycobacterium kansasii 1600:Bacterial skin disease 1498:Ureaplasma urealyticum 1291:Listeria monocytogenes 995:bacitracin resistant, 854:Pneumococcal infection 337:Johns Hopkins Medicine 2536:Elephantiasis nostras 2514:Necrotizing fasciitis 2427:Hospital furunculosis 2109:Brill–Zinsser disease 1740:Dermatitis gangrenosa 1519:Mycoplasma pneumoniae 1512:Mycoplasma genitalium 1351:Clostridium botulinum 1097:Enterococcus faecalis 872:Viridans streptococci 90:Staphylococcus aureus 18:Scalded skin syndrome 2571:Chronic lymphangitis 2240:Hot tub folliculitis 2229:Pseudomonal pyoderma 1856:Miliary tuberculosis 1846:Lichen scrofulosorum 1646:Toxic shock syndrome 1525:Mycoplasma pneumonia 1504:Ureaplasma infection 1214:novobiocin resistant 1172:Toxic shock syndrome 1111:Enterococcus faecium 311:. St. Louis: Mosby. 87:condition caused by 2460:Acute lymphadenitis 2453:Perianal cellulitis 2448:Pyogenic paronychia 2358:Chlamydia infection 2274:Granuloma inguinale 2248:Green nail syndrome 2244:Ecthyma gangrenosum 2119:Cat-scratch disease 1925:Tuberculoid leprosy 1836:Lepromatous leprosy 1683:Streptococcus iniae 1457:(non-spore forming) 1067:Streptococcus bovis 1027:Streptococcus iniae 775:Infectious diseases 381:J. Invest. Dermatol 2607:Bacterial diseases 2504:Pitted keratolysis 2415:Periapical abscess 1826:Erythema induratum 1811:Borderline leprosy 1801:Aquarium granuloma 1365:Clostridium tetani 1248:Bacillus anthracis 865:optochin resistant 780:Bacterial diseases 683:External resources 339:. 19 November 2019 182:pemphigus vulgaris 97:Signs and symptoms 2594: 2593: 2529:Fournier gangrene 2396: 2395: 2295: 2294: 2236:hot-foot syndrome 2209:Vibrio vulnificus 1976: 1975: 1972: 1971: 1920:Tuberculous gumma 1776: 1775: 1566: 1565: 1562: 1561: 1537:Anaeroplasmatales 1474: 1473: 1413: 1412: 1311: 1310: 1307: 1306: 1231: 1230: 1120: 1119: 1076: 1075: 1043: 1042: 922: 921: 731: 730: 451:(9252): 299–301. 318:978-1-4160-2999-1 74: 73: 27:Medical condition 16:(Redirected from 2624: 2566:Bullous impetigo 2487:Sycosis vulgaris 2301:Campylobacterota 2250: 1996: 1987: 1787: 1622: 1613: 1593: 1586: 1579: 1570: 1489:Mycoplasmataceae 1485: 1465:Finegoldia magna 1338: 1322: 1220:S. saprophyticus 1148: 1137: 933: 834: 825: 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977: 974: 972: 969: 967: 966:Scarlet fever 964: 962: 959: 957: 954: 953: 952: 951: 947:susceptible: 946: 943: 942: 940: 938: 934: 931: 929: 925: 915: 913: 909: 907: 906: 902: 900: 899: 895: 893: 892: 888: 886: 885: 881: 879: 878: 873: 870: 869: 867: 863: 855: 852: 851: 850: 849: 848:S. pneumoniae 845: 844: 842: 839: 835: 832: 830: 826: 823: 821: 820: 819:Streptococcus 815: 812: 809: 804: 800: 797: 795: 791: 785: 781: 778: 776: 772: 768: 765: 764: 759: 754: 752: 747: 745: 740: 739: 736: 723: 719: 718: 714: 712: 709: 705: 704: 700: 698: 694: 693: 689: 688: 685: 681: 674: 670: 669: 665: 663: 659: 658: 654: 652: 648: 647: 643: 639: 637: 633: 632: 628: 624: 623: 620: 615: 611: 604: 595: 591: 587: 583: 579: 575: 571: 567: 563: 556: 553: 548: 544: 540: 536: 533:(6): 958–67. 532: 528: 524: 517: 514: 509: 505: 501: 497: 493: 489: 482: 479: 474: 470: 466: 462: 458: 454: 450: 446: 439: 436: 431: 427: 423: 419: 412: 409: 404: 400: 395: 390: 386: 382: 378: 371: 368: 365: 364: 359: 354: 351: 338: 334: 328: 325: 320: 314: 310: 303: 300: 293: 289: 286: 284: 281: 280: 276: 274: 272: 271:scarlet fever 268: 262: 256: 254: 252: 244: 242: 240: 236: 232: 228: 224: 220: 216: 212: 208: 200: 198: 195: 187: 185: 183: 179: 175: 171: 167: 163: 159: 155: 151: 147: 139: 137: 135: 131: 126: 122: 120: 116: 112: 108: 104: 96: 94: 92: 91: 86: 82: 78: 70: 67: 65: 61: 56: 52: 47: 44: 40: 36: 31: 19: 2551:Malakoplakia 2477:Folliculitis 2401:Unspecified 2373:Lyme disease 2310:Helicobacter 2309: 2284: 2233: 2220: 2207: 2164: 2145:Gonococcemia 2056: 2036:Trench fever 2016:Scrub typhus 1956: 1877: 1869: 1861: 1821:Buruli ulcer 1790: 1765: 1735:Gas gangrene 1724: 1708: 1682: 1655: 1635: 1625: 1544: 1517: 1510: 1496: 1463: 1452: 1433: 1418: 1398:Gas gangrene 1390: 1382: 1363: 1349: 1341: 1325: 1289: 1279: 1260: 1246: 1236: 1218: 1213: 1204: 1196: 1166: 1159: 1140: 1109: 1095: 1083:Enterococcus 1081: 1065: 1025: 1000: 948: 912:S. anginosus 911: 903: 898:S. sanguinis 896: 889: 882: 875: 846: 817: 715: 701: 690: 666: 655: 640: 625: 569: 565: 555: 530: 526: 516: 494:(1): 88–91. 491: 487: 481: 448: 444: 438: 421: 417: 411: 387:(4): 700–3. 384: 380: 370: 361: 358:"exfoliatin" 353: 341:. Retrieved 336: 327: 308: 302: 263: 260: 248: 218: 214: 204: 193: 191: 170:desmoglein-1 157: 143: 127: 123: 115:desquamation 107:erythroderma 100: 88: 80: 76: 75: 2556:Pyomyositis 2264:Shigellosis 2234:Pseudomonas 2158:Melioidosis 2124:Oroya fever 2114:Brucellosis 1946:Nocardiosis 1756:Listeriosis 1726:Clostridium 1552:Erysipeloid 1327:Clostridium 1297:Listeriosis 1200:susceptible 950:S. pyogenes 905:S. sobrinus 840:susceptible 692:MedlinePlus 239:Clindamycin 211:paracetamol 69:Dermatology 38:Other names 2601:Categories 2444:Paronychia 2439:Cellulitis 2312:cellulitis 2223:cellulitis 2163:Cutaneous 1767:Mycoplasma 1717:Erythrasma 1690:Erysipelas 1681:Cutaneous 1480:Mollicutes 1454:Finegoldia 1383:nonmotile: 1317:Clostridia 1198:novobiocin 1126:Bacillales 971:Erysipelas 945:bacitracin 668:DiseasesDB 566:The Lancet 445:The Lancet 418:The Lancet 294:References 235:vancomycin 174:granulosum 162:desmosomes 154:exfoliatin 2434:Carbuncle 2287:infection 2285:Aeromonas 2279:Chancroid 2203:Tularemia 2167:infection 2149:Gonorrhea 2059:infection 1959:infection 1880:infection 1872:infection 1864:infection 1685:infection 1617:Bacillota 1427:-forming) 1334:-forming) 1161:S. aureus 1019:ungrouped 997:CAMP test 891:S. oralis 884:S. mutans 767:Bacillota 711:emerg/782 703:eMedicine 245:Prognosis 231:oxacillin 227:nafcillin 219:S. aureus 215:S. aureus 207:ibuprofen 201:Treatment 194:S. aureus 188:Diagnosis 158:S. aureus 150:exotoxins 64:Specialty 2519:Gangrene 2470:Pyoderma 2403:pathogen 2333:Syphilis 2328:Syphilid 2177:Glanders 1982:Gram -ve 1666:Impetigo 1641:Impetigo 1608:Gram +ve 1357:Botulism 1281:Listeria 1238:Bacillus 877:S. mitis 838:optochin 717:Orphanet 708:derm/402 594:35925579 586:11441870 473:35896288 465:11214144 403:15816826 277:See also 178:spinosum 146:syndrome 132:or have 2499:Ecthyma 2410:Abscess 2338:Chancre 2254:Q fever 1841:Leprosy 1793:related 1371:Tetanus 1342:motile: 1254:Anthrax 794:Bacilli 662:D013206 547:4252715 343:1 March 257:History 166:plasmid 83:) is a 2494:Pimple 2269:Plague 1934:Others 1749:Others 697:001352 651:695.81 592:  584:  545:  508:367152 506:  471:  463:  401:  315:  2353:Bejel 2348:Pinta 2321:Other 2191:Gamma 1999:Alpha 1425:spore 1332:spore 914:group 769:(low- 722:36236 673:29437 590:S2CID 469:S2CID 233:, or 2343:Yaws 2138:Beta 1177:MRSA 1131:Cat+ 808:Cat- 657:MeSH 646:9-CM 582:PMID 543:PMID 504:PMID 461:PMID 399:PMID 345:2023 313:ISBN 176:and 144:The 81:SSSS 1189:Cg- 1152:Cg+ 1094:+: 1092:BEA 1064:+: 1062:BEA 999:+: 771:G+C 642:ICD 636:L00 627:ICD 574:doi 570:357 535:doi 496:doi 492:133 453:doi 449:357 426:doi 422:156 389:doi 385:124 360:at 209:or 2603:: 2446:/ 2246:/ 2242:/ 2238:/ 2231:/ 1692:/ 874:: 784:G+ 782:: 773:) 720:: 706:: 695:: 671:: 660:: 649:: 634:: 631:10 588:. 580:. 568:. 564:. 541:. 531:78 529:. 525:. 502:. 490:. 467:. 459:. 447:. 420:. 397:. 383:. 379:. 335:. 229:, 184:. 136:. 93:. 2151:/ 2147:/ 1592:e 1585:t 1578:v 1423:( 1330:( 1133:) 1129:( 1057:D 1049:Îł 988:B 937:A 928:β 829:α 810:) 806:( 757:e 750:t 743:v 644:- 629:- 619:D 596:. 576:: 549:. 537:: 510:. 498:: 475:. 455:: 432:. 428:: 405:. 391:: 347:. 321:. 152:( 79:( 20:)

Index

Scalded skin syndrome
bullous impetigo

Specialty
Dermatology
dermatological
Staphylococcus aureus
Nikolsky's sign
erythroderma
intertriginous
desquamation
toxic epidermal necrolysis
immunosuppressed
kidney failure
syndrome
exotoxins
exfoliatin
desmosomes
plasmid
desmoglein-1
granulosum
spinosum
pemphigus vulgaris
ibuprofen
paracetamol
penicillinases
nafcillin
oxacillin
vancomycin
Clindamycin

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