101:, who described it in 1901. There is no known cure for this disease but it is not a life-threatening condition and is mainly of cosmetic concern, although, because it can appear so suddenly, so extensively and because it usually leaves permanent discoloration of the skin, it can cause understandable psychological concern. The skin lesions sometimes cause itching, which can be treated by applying cortisone cream. The cortisone cream will only help with the itching and does not improve the discoloration of the skin. Schamberg's disease causes no other symptoms beside skin discoloration and itching. The condition is caused by inflammation of capillaries near the surface of skin and subsequent leaking of red blood cells into surrounding tissues. As the red blood cells break down and get mostly resorbed, some of the iron released by the red blood cells remains in the skin and causes the characteristic rust-colored appearance. The cause of the capillary inflammation is usually unknown.
133:, which allow red blood cells to slip through into the skin. The red blood cells in the skin then fall apart and release their iron, which is released from hemoglobin. The iron causes a rust color and this accounts for the orange tint of the rash. Although the underlying cause for the leaky blood vessels is almost always unknown, researchers suggest some potential triggers. These include the body's inflammatory reaction to some agent, such as a viral infection or a prescription or over the counter medication or supplement, such as thiamine and aspirin. Even though there is no correlation with genetics, there have been a few cases where few people in a family had this condition.
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sensitive to food with artificial colors or preservatives should avoid foods containing those items. This is because some people have been observed to be sensitive to these agents, and the body initiates an inflammatory reaction if exposed to them again, which causes further capillary inflammation and red blood cell leakage. Several research studies have indicated that
Schamberg's disease can be controlled and the number of lesions can be reduced with the use of a drug called
40:
717:
174:, the condition is often readily diagnosed, because the visual appearance of the lesions on the skin itself usually suggests the possibility that the cause may be Schamberg's disease. While reviewing medical history is important to diagnose this condition, it is essential that the skin be physically examined.
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Schamberg's disease is a skin disorder that causes a discoloration of the lower extremities. It usually occurs in the lower extremities and rarely elsewhere. This condition is caused by leaky blood vessels near the surface of the skin. The cause of the leaky capillaries is usually not known. When the
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A patient with
Schamberg's disease can live a normal and healthy life. Since there is no proven cure for this condition, the patient will have to endure the lesions on his or her skin. With appropriate treatments, the condition may get better. Although the skin lesions are not life-threatening, it
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Many topical and systemic therapies for
Schamberg disease have been tried without consistent results. A case series published in 2012 describes the treatment of five patients with Schamberg's disease of the lower extremities using Advanced Fluorescence Technology (AFT) pulsed light with favorable
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The lesions are most frequent on the lower limbs, but may occur anywhere on the body, including the hands, arms, torso and even the neck. They may vary in number and erupt in mass numbers. They consist of irregular patches of orange or brown pigmentation with characteristic "cayenne pepper" spots
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To ensure that the skin lesions are not caused by other skin conditions or infections, a doctor will often order a complete blood count (CBC) and other blood tests. Blood test results are usually normal. They are performed primarily to rule out other bleeding disorders that cause purpura. Since
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Additional testing may aid diagnosis. A skin biopsy may be taken to determine capillaritis of dermal vessels. Capillaritis or pigmented purpura is skin condition that has brown-reddish patches on the skin, which is caused by leaky capillaries. Such skin biopsies are sent to a laboratory for a
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treatment has been used to prevent recurrence. Some recommend that patients take a vitamin C supplement to promote collagen production, but this is not proven to be helpful. In cases where there is a known trigger, people should avoid re-exposure to that trigger, e.g., people suspected to be
110:
appearing within and at the edge of old lesions. There are usually no symptoms, although there may be some slight itching, but there is no pain. The eruption may persist for many years. The pattern of the eruption changes, with slow extension and often some clearing of the original
121:, is a chronic discoloration of the skin which usually affects the legs and often spreads slowly. This disease is more common in males and may occur at any age from childhood onward. This condition is observed worldwide and has nothing to do with race or ethnic background.
205:
There is no cure for
Schamberg's disease, however, this condition is not life-threatening or a major health concern. The most usual problems that patients will encounter is discoloration of the skin and, occasionally, itching. Itching may be improved by applying a
154:, which in turn breaks apart, releasing Iron. (Iron is the part of hemoglobin that enables it to transfer oxygen from the lungs to the cells and carbon dioxide from the cells to the lungs.) The iron released into the skin gets bound up into a complex called
96:
discoloration of the skin found in people of all ages, usually only affecting the feet, legs or thighs or a combination. It may occur as a single event or subsequent bouts may cause further spread. It is most common in males. It is named after
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Although a definite cause for capillary inflammation is almost always unknown, certain preventive measures can be taken. Doctors may prescribe medications that enhance the circulation of blood, which can keep blood vessels strong and healthy.
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Schober, S. M.; Peitsch, W. K.; Bonsmann, G.; Metze, D.; Thomas, K.; Goerge, T.; Luger, T. A.; Schneider, S. W. (2014). "Early treatment with rutoside and ascorbic acid is highly effective for progressive pigmented purpuric dermatosis".
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With a complete history, the results from visual examination, and the aid of appropriate laboratory testing, a dermatologist can usually determine whether the skin lesions are in fact due
Schamberg's disease.
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may cause a cosmetic concern for some individuals. Skin lesions may cause psychological discomfort, where patients may require reassurance to help with stress and anxiety. There are a few rare cases of
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that have developed from
Schamberg's disease. This is not a cause for concern, since the risk factors associated with Schamberg's disease are relatively low.
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may be an efficient and well tolerated treatment for PPPD, with a recommendation for early treatment for best clinical outcome.
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Schamberg's disease is usually asymptomatic beyond the visible lesions themselves, few other tests are usually indicated.
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A few very small non-blinded studies of treatment with narrow-band ultraviolet light have been reported as promising.
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Schamberg's disease can only be properly diagnosed by a healthcare provider. For a trained skin specialist such as a
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Rust-colored spots typical of
Schamberg disease on the lower left leg and left foot of a 26-year-old Caucasian male.
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pathological examination, where each biopsy is observed under a microscope. A dermatologist may also perform a
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escape the blood vessels, they end up close under the skin surface, where they break apart, releasing
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476:"Progressive Pigmentary Purpura - American Osteopathic College of Dermatology (AOCD)"
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Schamberg's disease is caused by leaky blood vessels near the surface of the skin,
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of
Schamberg disease, suggesting the spongiotic stage of a purpuric dermatitis.
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219:. This drug helps reduce capillary fragility and red blood cell leakage.
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685:"Treatment of Schamberg's Disease with Advanced Fluorescence Technology"
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441:"Schamberg's Disease Treatment - Home Remedies for Schamberg's Disease"
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384:"Causes Of Schamberg's Disease: Symptoms, Diagnosis & Treatment"
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554:"How to get rid of Schamberg's Disease | Chronic Lesions on Legs"
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Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
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de Godoy, José Maria
Pereira; Batigália, Fernando (2009-06-11).
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James, William D.; Berger, Timothy G.; et al. (2006).
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Manolakos, Danielle; Weiss, Jonathan; Glick, Brad (2012).
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Schamberg's disease, or progressive pigmented purpuric
503:"Schamberg's Disease. Read About Schamberg's Disease"
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582:"Aminaphtone in the control of Schamberg's disease"
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210:cream. Rarely, in very severe or concerning cases,
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32:
1382:Inherited patterned lentiginosis in black persons
1591:Eczematid-like purpura of Doucas and Kapetanakis
158:, which causes the discoloration of the skin.
78:progressive pigmentary dermatosis of Schamberg
1243:Yemenite deaf-blind hypopigmentation syndrome
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779:: CS1 maint: multiple names: authors list (
642:Journal of the German Society of Dermatology
224:Journal of the German Society of Dermatology
1311:Reticular pigmented anomaly of the flexures
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414:"What is Schamberg's Disease? - Skin Site"
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1587:Doucas and Kapetanakis pigmented purpura
1316:Naegeli–Franceschetti–Jadassohn syndrome
1326:X-linked reticulate pigmentary disorder
1306:Reticulate acropigmentation of Kitamura
1301:Pigmentatio reticularis faciei et colli
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1698:Dyschromatosis universalis hereditaria
1503:Familial progressive hyperpigmentation
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731:Dhali TK, Chahar M, Haroon MA (2015).
1774:Vascular-related cutaneous conditions
1693:Dyschromatosis symmetrica hereditaria
1528:Transient neonatal pustular melanosis
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228:Deutsche Dermatologische Gesellschaft
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1518:Photoleukomelanodermatitis of Kobori
1296:Dermatopathia pigmentosa reticularis
527:"Capillaritis | DermNet New Zealand"
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1443:Poikiloderma vasculare atrophicans
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1228:Postinflammatory hypopigmentation
1172:Progressive macular hypomelanosis
222:A study published in 2014 on the
1162:Idiopathic guttate hypomelanosis
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1646:Titanium metallic discoloration
1402:Partial unilateral lentiginosis
690:Journal of Drugs in Dermatology
1419:Erythema dyschromicum perstans
82:purpura pigmentosa progressiva
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1608:Hemosiderin hyperpigmentation
1567:Pigmented purpuric dermatosis
1513:Periorbital hyperpigmentation
1009:Vogt–Koyanagi–Harada syndrome
749:10.1590/abd1806-4841.20153067
1475:Shiitake mushroom dermatitis
1562:Iron metallic discoloration
1238:Vagabond's leukomelanoderma
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1508:Pallister–Killian syndrome
1157:Albinism–deafness syndrome
445:www.best-home-remedies.com
1424:Lichen planus pigmentosus
1372:Centrofacial lentiginosis
1129:Griscelli syndrome type 3
1124:Griscelli syndrome type 2
1104:Hermansky–Pudlak syndrome
287:Dermatology: 2-Volume Set
46:
37:
1377:Generalized lentiginosis
1109:Chédiak–Higashi syndrome
558:www.depression-guide.com
18:Schamberg's disease
1438:Poikiloderma of Civatte
1074:Oculocutaneous albinism
1582:Gougerot–Blum syndrome
1465:Incontinentia pigmenti
1321:Dyskeratosis congenita
1248:Wende–Bauckus syndrome
1167:Phylloid hypomelanosis
938:Pigmentation disorders
729:Summarized in 2015 by
230:) concludes that oral
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1004:Alezzandrini syndrome
983:Quadrichrome vitiligo
599:10.1186/1477-9560-7-8
314:. Saunders Elsevier.
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1601:Angioma serpiginosum
1493:Acanthosis nigricans
1032:Waardenburg syndrome
289:. St. Louis: Mosby.
1331:Galli–Galli disease
1223:Nevus depigmentosus
355:"Schamberg Disease"
99:Jay Frank Schamberg
90:Schamberg's purpura
74:Schamberg's disease
33:Schamberg's disease
1577:Majocchi's disease
1470:Scratch dermatitis
1397:Mucosal lentigines
1197:Vasospastic macule
1114:Griscelli syndrome
870:External resources
586:Thrombosis Journal
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76:, (also known as "
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1636:Arsenic poisoning
1572:Schamberg disease
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1119:Elejalde syndrome
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895:Schamberg disease
654:10.1111/ddg.12520
531:www.dermnetnz.org
390:. 18 January 2017
388:www.tandurust.com
296:978-1-4160-2999-1
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16:(Redirected from
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1190:hypomelanosis
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1152:ABCD syndrome
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236:ascorbic acid
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1434:Poikiloderma
1358:Lentiginosis
888:
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827:
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775:cite journal
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706:. Retrieved
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589:
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561:. Retrieved
557:
534:. Retrieved
530:
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510:. Retrieved
507:patient.info
506:
483:. Retrieved
480:www.aocd.org
479:
448:. Retrieved
444:
421:. Retrieved
417:
392:. Retrieved
387:
362:. Retrieved
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195:dermatoscopy
191:
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116:
108:
89:
85:
81:
77:
73:
72:
1662:Carotenosis
1289:Reticulated
1020:development
966:melanocytes
743:(1): 96–9.
708:8 September
217:aminaphtone
156:hemosiderin
131:capillaries
58:Dermatology
1763:Categories
1714:Skin color
1685:Dyschromia
1631:Chrysiasis
1367:Liver spot
1186:Leukoderma
1094:Melanosome
1027:Piebaldism
1018:Melanocyte
942:Dyschromia
890:Patient UK
855:DiseasesDB
563:2017-11-06
536:2017-11-07
512:2017-11-06
485:2017-11-07
450:2017-11-06
423:2017-11-05
394:2017-11-05
364:2017-11-05
267:References
212:Colchicine
186:Micrograph
152:hemoglobin
119:dermatosis
1486:ungrouped
1276:Melanosis
1216:Ungrouped
1084:in humans
1057:amelanism
997:Syndromic
879:eMedicine
608:1477-9560
418:Skin Site
246:Prognosis
242:results.
208:cortisone
201:Treatment
162:Diagnosis
141:Mechanism
53:Specialty
1707:See also
1543:pigments
1345:Diffuse/
1281:Melanism
1097:transfer
1066:Albinism
1050:Loss of
975:Vitiligo
884:derm/327
767:25672304
703:22453593
670:13538334
662:25482694
626:19515261
232:rutoside
105:Symptoms
92:") is a
88:), and "
1741:removal
1729:Sunless
1724:Tanning
1626:Argyria
1498:Freckle
1414:Melasma
1354:Lentigo
1271:Melanin
1052:melanin
963:Loss of
955:leucism
849:D010859
758:4323703
617:2703626
359:DoveMed
112:lesions
94:chronic
1736:Tattoo
1619:metals
1484:Other/
1458:Linear
1262:Hyper-
838:709.09
765:
755:
701:
668:
660:
624:
614:
606:
318:
293:
125:Causes
60:
1655:Other
1617:Other
1541:Other
1140:Other
950:Hypo-
860:30753
823:L81.7
666:S2CID
592:: 8.
1550:Iron
844:MeSH
833:9-CM
781:link
763:PMID
710:2020
699:PMID
658:PMID
622:PMID
604:ISSN
316:ISBN
291:ISBN
234:and
80:", "
1188:w/o
829:ICD
814:ICD
753:PMC
745:doi
650:doi
612:PMC
594:doi
86:PPP
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226:(
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