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29:
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Rissi VB, Glanzner WG, Mujica LK, Antoniazzi AQ, Gonçalves PB, Bordignon V (February 2016). "Effect of Cell Cycle
Interactions and Inhibition of Histone Deacetylases on Development of Porcine Embryos Produced by Nuclear Transfer".
621:
41:
426:"Scriptaid, a novel histone deacetylase inhibitor, protects against traumatic brain injury via modulation of PTEN and AKT pathway : scriptaid protects against TBI via AKT"
473:
Zhu X, Nie J, Quan S, Xu H, Yang X, Lu Y, et al. (February 2016). "In vitro production of cloned and transgenically cloned embryos from
Guangxi Huanjiang Xiang pig".
265:
362:
Su GH, Sohn TA, Ryu B, Kern SE (June 2000). "A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library".
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that acts at this target. Scriptaid itself was never developed for medical applications, but led to the development of structurally related drugs such as
943:
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65:
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InChI=1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
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337:, which have been accepted into clinical use. Most early research using these compounds focused on their
791:
554:"Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation"
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187:
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706:
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552:
Gaur V, Connor T, Sanigorski A, Martin SD, Bruce CR, Henstridge DC, et al. (September 2016).
341:
activity, but more recent research has found scriptaid to be useful in other applications such as
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Wang G, Jiang X, Pu H, Zhang W, An C, Hu X, et al. (January 2013).
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Monneret C (January 2005). "Histone deacetylase inhibitors".
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In Vitro
Cellular & Developmental Biology. Animal
329:, and was one of the first compounds discovered via
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287:C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCCC(=O)NO
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345:and research into regulation of metabolism.
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647:β-Hydroxybutyric acid (β-hydroxybutyrate)
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391:European Journal of Medicinal Chemistry
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73:6-(1,3-Dioxobenzoisoquinolin-2-yl)-
892:. You can help Knowledge (XXG) by
14:
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225:
219:
27:
657:Acetoacetic acid (acetoacetate)
312:Key:JTDYUFSDZATMKU-UHFFFAOYSA-N
944:Histone deacetylase inhibitors
939:Drugs not assigned an ATC code
631:Histone deacetylase inhibitors
231:
213:
1:
862:Receptor/signaling modulators
327:histone deacetylase inhibitor
571:10.1016/j.celrep.2016.08.005
403:10.1016/j.ejmech.2004.10.001
787:Sodium oxybate (GHB sodium)
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871:
325:is a drug which acts as a
203:Chemical and physical data
855:
827:Valproic acid (valproate)
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487:10.1007/s11626-015-9957-0
442:10.1007/s13311-012-0157-2
331:high-throughput screening
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275:
61:
26:
677:Butyric acid (butyrate)
888:-related article is a
531:10.1089/cell.2015.0052
519:Cellular Reprogramming
792:Sodium phenylbutyrate
642:3,3'-Diindolylmethane
581:10536/DRO/DU:30086375
837:Valproate semisodium
23:
954:Pharmacology stubs
77:-hydroxyhexanamide
901:
900:
869:
868:
847:Vorinostat (SAHA)
832:Valproate pivoxil
717:Indole-3-carbinol
697:Diallyl disulfide
564:(11): 2802–2810.
430:Neurotherapeutics
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266:Interactive image
172:CompTox Dashboard
16:Chemical compound
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949:Hydroxamic acids
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797:Sodium valproate
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370:(12): 3137–42.
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36:Clinical data
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894:expanding it
886:pharmacology
883:
858:
857:
822:Valnoctamide
817:Tucidinostat
802:Sulforaphane
776:
747:Parthenolide
742:Panobinostat
732:Mocetinostat
707:Fimepinostat
687:Citarinostat
561:
558:Cell Reports
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767:Resminostat
762:Quisinostat
757:Pracinostat
737:Niacinamide
727:Martinostat
652:Abexinostat
525:(1): 8–16.
397:(1): 1–13.
339:anti-cancer
249: g·mol
96:287383-59-9
57:Identifiers
933:Categories
842:Valpromide
807:Trapoxin B
772:Romidepsin
712:Givinostat
702:Entinostat
672:Belinostat
349:References
335:vorinostat
254:3D model (
242:Molar mass
161:EJQ8CD8BSV
132:ChemSpider
87:CAS Number
66:IUPAC name
859:See also:
777:Scriptaid
682:Capsaicin
323:Scriptaid
21:Scriptaid
722:Kevetrin
692:Curcumin
667:Apicidin
590:27626651
539:27281695
503:15676479
495:26559066
460:23132328
411:15642405
376:10866300
42:ATC code
451:3557358
343:cloning
247:326.352
209:Formula
107:PubChem
588:
537:
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448:
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374:
280:SMILES
884:This
499:S2CID
300:InChI
256:JSmol
890:stub
586:PMID
535:PMID
491:PMID
456:PMID
407:PMID
372:PMID
152:UNII
141:4998
121:5186
49:none
576:hdl
566:doi
527:doi
483:doi
446:PMC
438:doi
399:doi
177:EPA
111:CID
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235:4
232:O
229:2
226:N
220:H
214:C
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175:(
75:N
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