Knowledge (XXG)

Select agent

Source đź“ť

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Bioterrorism Act of 2002, the OIG had received 68 referrals from the CDC for possible Select Agent enforcement and found violations in 30 of those cases. Notices of violation were sent to 5 federal entities, 3 universities, and 2 other private organizations, all unnamed in his testimony. Demske remarked that no federal agencies had been fined for SAP violations.
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detects possible SAP misconduct by an HHS worker, it coordinates with the OIG to gather facts. If it concludes that a civil violation might have occurred, it turns the case over to the OIG for possible enforcement. But if it suspects a crime, it pursues the matter with the FBI. Since passage of the
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Select agent regulations were revised in October 2012 to designate thirteen "Tier 1" agents with a documented risk of causing a high consequence event higher than other BSATs. Criteria for Tier 1 status were (1) Ability to produce a mass casualty event or devastating effects to the economy; (2)
1147:– The FSAP is composed jointly of the Centers for Disease Control and Prevention/Division of Select Agents and Toxins and the Animal and Plant Health Inspection Service/Agriculture Select Agent Services, and oversees the possession, use and transfer of biological select agents and toxins. 1805: 156:
research. It is composed of government, education and industry experts who provide policy recommendations on ways to minimize the possibility that knowledge and technologies emanating from biological research will be misused to threaten public health or national security.
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research. It is composed of government, education and industry experts who provide policy recommendations on ways to minimize the possibility that knowledge and technologies emanating from biological research will be misused to threaten public health or national security.
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Communicability; (3) Low infectious dose; and (4) History of or current interest in weaponization based on threat reporting. In the same revision Chapare virus, Lujo virus, and SARS-associated coronavirus (SARS-CoV) were added to the list of select agents.
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National Research Council (US) Committee on Laboratory Security and Personnel Reliability Assurance Systems for Laboratories Conducting Research on Biological Select Agents and Toxins. (2009). "Chapter 1. Introduction".
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Criteria for removal from the BSAT list were (1) Low potential for causing mortality; (2) Endemicity in the U.S. (animal agents); and (3) Difficulty in producing quantities necessary for high consequence
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The CDC has regulated the laboratories which may possess, use, or transfer select agents within the United States under the SAP since 2001. The SAP was established to satisfy requirements of the
1404: 1373: 169:), testified that 30 civil violations of the SAP rules had been identified in the past 13 years, and that violators had paid about $ 2.4 million in fines. He explained that when the CDC's 1856: 1658: 1241: 1459: 1387: 1453: 1443: 1185: 2144: 2100: 1303: 149: 109: 2056: 1469: 1079: 1226: 459:
and toxins are considered to "have the potential to pose a severe threat to both human and animal health, to plant health, or to animal and plant products".
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A federal advisory committee that addresses issues related to biosecurity and dual use research at the request of the United States Government.
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Select agent regulations were revised in October 2012 to remove 19 BSATs from the list (7 Human and Overlap Agents and 12 Animal Agents).
58:(USDA) to have the "potential to pose a severe threat to public health and safety". The agents are divided into (1) HHS select agents and 2233: 1882: 1414: 2084: 1439: 1218: 2134: 1778: 1643: 1628: 1475: 1261: 833: 293: 62:
affecting humans; (2) USDA select agents and toxins affecting agriculture; and (3) overlap select agents and toxins affecting both.
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In July 2015, Gregory E. Demske, chief counsel to the inspector general in the HHS Office of Inspector General (
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Middle-Atlantic Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research
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Global Partnership Against the Spread of Weapons and Materials of Mass Destruction
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virus containing any portion of the coding regions of all eight gene segments.
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Additional Requirements for Facilities Transferring or Receiving Select Agents
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Public Health Security and Bioterrorism Preparedness and Response Act of 2002
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Public Health Security and Bioterrorism Preparedness and Response Act of 2002
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Johns Hopkins Center for Health Security (formerly Center for Biosecurity)
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Statement on Chemical and Biological Defense Policies and Programs
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Using select agents in biomedical research prompts concerns about
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Pandemic and All-Hazards Preparedness Reauthorization Act of 2013
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Public Health Security and Bioterrorism Preparedness Response Act
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Joint Program Executive Office of Chemical and Biological Defense
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This refers to reconstructed, replication-competent forms of the
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Biodefense and Pandemic Vaccine and Drug Development Act of 2005
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Integrated National Biodefense Medical Countermeasures Portfolio
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Office of the Assistant Secretary for Preparedness and Response
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National Medical Response Team/National Pharmacy Response Team
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Responsible Research with Biological Select Agents and Toxins
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Joint Biological Agent Identification and Diagnostic System
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Bioterror Rapid Response and Advanced Technology Laboratory
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U.S. Army Medical Research Institute of Infectious Diseases
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Global Emerging Infections Surveillance and Response System
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National Interagency Confederation for Biological Research
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Using BSATs in biomedical research prompts concerns about
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small colony (Mmm SC) (contagious bovine pleuropneumonia)
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National Intelligence Assessments on Infectious Diseases
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Johns Hopkins Center for Civilian Biodefense Strategies
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National Biodefense Analysis and Countermeasures Center
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National Center for Biodefense and Infectious Diseases
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Biomedical Advanced Research and Development Authority
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United States Department of Health and Human Services
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Washington DC: National Academies Press. 67:Centers for Disease Control and Prevention 2107:Pandemic and All-Hazards Preparedness Act 1581:Aeromedical Biological Containment System 1535:Nebraska Biocontainment Patient Care Unit 1410:Defense Advanced Research Projects Agency 1322:Assistant SECDEF for NCB Defense Programs 441:Sabiá virus (Brazilian hemorrhagic fever) 308:Far-Eastern tick-borne encephalitis virus 2220:United States biological weapons program 1343:National Center for Medical Intelligence 1195:United States biological defense program 133:, which were enacted in the wake of the 93:, which were enacted in the wake of the 1879:National Strategy for Homeland Security 1027:Department of Health and Human Services 985: 361:Viral hemorrhagic fever (VHF) viruses: 1378:National Interagency Biodefense Campus 1247:National Bio and Agro-Defense Facility 1649:Center for Biodefense Immune Modeling 1084:CDC/USDA Federal Select Agent Program 368:Crimean–Congo hemorrhagic fever virus 148:. The federal government created the 108:. The federal government created the 7: 1967:Autonomous Pathogen Detection System 1294:Division of Select Agents and Toxins 1272:(Advisory Committee on Bioterrorism) 1270:National Counterproliferation Center 1252:National Bioforensic Analysis Center 920:(contagious caprine pleuropneumonia) 851:Venezuelan equine encephalitis virus 296:(excluding South American genotypes) 171:Division of Select Agents and Toxins 1415:Edgewood Chemical Biological Center 1800:Bio-Surveillance Management Office 1466:Homeland Security Research Program 36:Biological select agents or toxins 25: 2135:Global Health Security Initiative 1779:National Biosurveillance Strategy 1476:Plum Island Animal Disease Center 834:Eastern equine encephalitis virus 294:Eastern equine encephalitis virus 2265:Biosecurity in the United States 2171:1984 Rajneeshee bioterror attack 2001:Positive pressure personnel suit 1893:National Disaster Medical System 969:Biosecurity in the United States 903:(Alcelaphine herpesvirus type 1) 759:Peronosclerospora philippinensis 691:Peste des petits ruminants virus 524:Overlap select agents and toxins 2320:Smallpox virus retention debate 2215:United States Army Medical Unit 1741:Defense Threat Reduction Agency 1327:Defense Threat Reduction Agency 1080:"Select Agents and Toxins List" 974:U.S. biological defense program 901:Malignant Catarrhal Fever virus 845:Tick-borne encephalitis viruses 874:Bovine spongiform encephalitis 752:Fungi or fungus-like pathogens 611:Venezuelan equine encephalitis 112:which promotes biosecurity in 56:U.S. Department of Agriculture 1: 2176:1989 California medfly attack 2040:Biological Weapons Convention 1838:Personnel Reliability Program 1571:Epidemic Intelligence Service 1436:Galveston National Laboratory 853:, enzootic subtypes ID and IE 618:USDA select agents and toxins 400:Kyasanur Forest disease virus 1899:Strategic National Stockpile 1450:Integrated Research Facility 1232:DHS Office of Health Affairs 1143:Federal Select Agent Program 801:List of former select agents 437:(Bolivian hemorrhagic fever) 411:South American VHF viruses: 405:Omsk hemorrhagic fever virus 188:HHS select agents and toxins 79:Federal Select Agent Program 1962:Biological Materials MASINT 1875:National Response Framework 1784:Laboratory Response Network 1745:Biological Threat Reduction 1689:Battelle Memorial Institute 951:citrus variegated chlorosis 896:Japanese encephalitis virus 498:Staphylococcal enterotoxins 429:Argentine hemorrhagic fever 283:SARS-associated coronavirus 2367: 2230:Aeromedical Isolation Team 1041:Government Printing Office 836:, South American genotypes 764:Peronosclerospora sacchari 152:to promote biosecurity in 135:September 11, 2001 attacks 95:September 11, 2001 attacks 669:virus (highly pathogenic) 577:Burkholderia pseudomallei 507:2 Type A trichothecenes: 232:Burkholderia pseudomallei 1802:(BMO) (part of JPEO-CBD) 1530:State Health Departments 1514:Local Health Departments 1156:Office of Science Policy 809:Human and overlap agents 794:Synchytrium endobioticum 686:Lumpy skin disease virus 582:Pseudomonas pseudomallei 237:Pseudomonas pseudomallei 2310:Isolation (health care) 2280:Biological warfare (BW) 1653:University of Rochester 1624:Henry L. Stimson Center 702:Swine vesicular disease 476:Clostridium perfringens 455:As of April 2021 these 300:Tick-borne encephalitis 821:Coccidioides posadasii 783:Sclerophthora rayssiae 730:Ralstonia solanacearum 680:Foot-and-mouth disease 655:African horse sickness 290:Encephalitis viruses: 244:Francisella tularensis 202:-producing species of 2305:Entomological warfare 2206:Defunct organizations 2186:Wood Green ricin plot 2090:Project Bioshield Act 2067:Executive Order 13139 1420:Dugway Proving Ground 1004:Roos, Robert (2015), 913:Mycoplasma capricolum 776:Pyrenochaeta glycines 738:Rathayibacter toxicus 469:Botulinum neurotoxins 364:African VHF viruses: 259:Rickettsia rickettsii 252:Rickettsia prowazekii 178:List of select agents 2181:2001 anthrax attacks 1849:Medical intelligence 1832:Select Agent Program 1756:Project Clear Vision 929:Vesicular stomatitis 885:Erlichia ruminantium 828:Coccidioides immitis 330:1918 influenza virus 139:2001 anthrax attacks 99:2001 anthrax attacks 71:Select Agent Program 847:, European subtypes 661:African swine fever 637:Mycoplasma mycoides 565:Burkholderia mallei 551:Brucella melitensis 396:Asian VHF viruses: 354:Variola minor virus 348:Variola major virus 220:Burkholderia mallei 137:and the subsequent 97:and the subsequent 2197:2013 ricin letters 2192:2003 ricin letters 1739:, implemented the 1668:George Mason Univ. 943:Xylella fastidiosa 745:Xanthomonas oryzae 570:Pseudomonas mallei 536:Bacillus anthracis 511:Diacetoxyscirpenol 350:* (smallpox virus) 319:Influenza viruses: 225:Pseudomonas mallei 77:)—also called the 2328: 2327: 2275:Biological hazard 2243: 2242: 2121: 2120: 2009: 2008: 1996:Biosafety cabinet 1908: 1907: 1867:Disaster response 1761:Project Jefferson 1716: 1715: 1712: 1711: 1694:SRI International 1596: 1595: 1495: 1494: 1351: 1350: 1067:1918 flu pandemic 771:Phoma glycinicola 709:Newcastle disease 605:Rift Valley fever 457:biological agents 379:Lassa fever virus 213:Coxiella burnetii 32:United States law 16:(Redirected from 2358: 2270:Biological agent 2225:Sunshine Project 2159: 2018: 1919: 1881:(DHS; including 1730:Threat reduction 1727: 1699:Idaho Technology 1638:Brown University 1610:Academic centers 1607: 1504: 1362: 1215: 1206: 1188: 1181: 1174: 1165: 1159: 1146: 1127: 1106: 1102: 1096: 1095: 1093: 1091: 1076: 1070: 1063: 1057: 1056: 1049: 1043: 1036:Federal Register 1022: 1016: 1015:(18 July issue). 1002: 996: 990: 964:Biological agent 869:Bluetongue virus 733:race 3, biovar 2 544:Brucella abortus 129:of 2001 and the 89:of 2001 and the 54:(HHS) or by the 21: 2366: 2365: 2361: 2360: 2359: 2357: 2356: 2355: 2331: 2330: 2329: 2324: 2300:Decontamination 2285:Biosurveillance 2239: 2207: 2201: 2163: 2162:Past biological 2150: 2127: 2117: 2045: 2028:Geneva Protocol 2005: 1991:Biosafety level 1977: 1945: 1914: 1904: 1861: 1843: 1817: 1771:Biosurveillance 1765: 1751:Project Bacchus 1722: 1708: 1680: 1673: 1612:and think tanks 1611: 1602: 1592: 1539: 1518: 1491: 1424: 1393: 1366: 1357: 1347: 1308: 1275: 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989: 986: 979: 975: 972: 970: 967: 965: 962: 961: 957: 952: 948: 945: 944: 940: 939: 935: 930: 927: 925: 922: 919: 915: 914: 910: 908: 905: 902: 899: 897: 894: 892: 889: 887: 886: 882: 880: 877: 875: 872: 870: 867: 865: 864:Akabane virus 862: 861: 858:Animal agents 857: 852: 849: 846: 843: 841: 838: 835: 832: 830: 829: 825: 823: 822: 818: 816: 813: 812: 808: 806: 800: 796: 795: 791: 789: 785: 784: 780: 777: 773: 772: 768: 765: 761: 760: 756: 755: 751: 747: 746: 742: 740: 739: 735: 732: 731: 727: 726: 722: 718: 715: 710: 706: 703: 700: 697: 694: 692: 689: 687: 684: 681: 678: 675: 671: 668: 665: 662: 659: 656: 653: 652: 648: 643: 639: 638: 634: 633: 629: 625: 622: 617: 612: 609: 606: 603: 601: 598: 596: 593: 592: 588: 583: 579: 578: 574: 571: 567: 566: 562: 560: 559: 558:Brucella suis 555: 553: 552: 548: 546: 545: 541: 538: 537: 533: 532: 528: 523: 517: 514: 512: 509: 508: 506: 504: 501: 499: 496: 494: 491: 489: 486: 484: 481: 479:epsilon toxin 478: 477: 473: 470: 467: 465: 462: 461: 460: 458: 450: 442: 439: 436: 433: 430: 426: 423: 421: 418: 416: 415:Chapare virus 413: 412: 410: 406: 403: 401: 398: 397: 395: 390: 389:Marburg virus 387: 385: 382: 380: 377: 374: 371: 369: 366: 365: 363: 362: 360: 355: 352: 349: 346: 344: 341: 340: 338: 335: 331: 327: 325: 322: 321: 320: 317: 310: 307: 304: 303: 301: 298: 295: 292: 291: 289: 284: 281: 280: 279:Coronavirus: 278: 277: 273: 268: 267: 263: 261: 260: 256: 254: 253: 249: 246: 245: 241: 238: 234: 233: 229: 226: 222: 221: 217: 215: 214: 210: 207: 206: 201: 197: 196: 192: 187: 182: 181: 177: 175: 172: 168: 160: 158: 155: 151: 147: 142: 140: 136: 132: 128: 120: 118: 115: 111: 107: 102: 100: 96: 92: 88: 84: 80: 76: 72: 68: 63: 61: 57: 53: 49: 45: 44:select agents 42:s)—or simply 41: 37: 33: 19: 2315:Select agent 2314: 2295:CBRN defense 2290:Bioterrorism 2208:and programs 2030:(1925, 1975) 1723:and projects 1603:governmental 1382:Fort Detrick 1367:departmental 1155: 1142: 1122: 1100: 1088:. Retrieved 1083: 1074: 1061: 1047: 1034: 1020: 1009: 1000: 992: 988: 946: 941: 936:Plant agents 917: 911: 883: 840:Flexal virus 826: 819: 804: 792: 787: 781: 775: 769: 763: 757: 743: 736: 728: 716: 641: 635: 623: 595:Hendra virus 581: 580:* (formerly 575: 569: 568:* (formerly 563: 556: 549: 542: 534: 503:Tetrodotoxin 474: 454: 356:* (Alastrim) 318: 264: 257: 250: 242: 236: 235:* (formerly 230: 224: 223:* (formerly 218: 211: 203: 164: 154:life science 143: 124: 114:life science 103: 82: 78: 74: 70: 64: 43: 39: 35: 29: 18:Select Agent 2351:Biosecurity 2073:Patriot Act 2050:Legislation 1957:Cell CANARY 1941:Respirators 1823:Biosecurity 1704:Phoenix Air 1681:contractors 916:subspecies 674:swine fever 640:subspecies 624:For animals 600:Nipah virus 425:Junin virus 373:Ebola virus 205:Clostridium 2335:Categories 2260:Biodefense 1923:Protection 1913:Technology 1901:(CDC, DHS) 1825:/Biosurety 1814:(Civilian) 1792:(EPA, CDC) 1747:(DoD) plus 1679:Government 1390:(DHHS/DoD) 1339:(JPEO-CBD) 980:References 774:(formerly 717:For plants 696:Rinderpest 672:Classical 483:Conotoxins 384:Lujo virus 285:(SARS-CoV) 200:neurotoxin 198:Botulinum 161:Violations 121:Regulation 48:bio-agents 2164:incidents 1950:Detection 707:Virulent 516:T-2 toxin 493:Saxitoxin 65:The U.S. 2021:Treaties 1974:(JBAIDS) 1936:NBC suit 1798:(GBTI), 1790:BioWatch 1721:Programs 1666:(NCBID; 1500:Response 1429:Civilian 1398:Military 1358:research 1236:BioWatch 1090:27 April 1029:(2012), 958:See also 723:Bacteria 642:mycoides 630:Bacteria 529:Bacteria 193:Bacteria 146:dual use 106:dual use 2155:History 1877:of the 1806:ESSENCE 1544:Federal 1356:Federal 1209:Federal 953:strain) 711:virus 1 649:Viruses 589:Viruses 435:Machupo 274:Viruses 2346:Toxins 2188:(2002) 2147:(2004) 2109:(2006) 2103:(2005) 2092:(2004) 2081:(2002) 2075:(2001) 2069:(1999) 2042:(1972) 2036:(1969) 1895:(DHHS) 1557:, HHS) 1488:(USDA) 1365:Trans- 1139:"Home" 1105:event. 1011:CIDRAP 698:virus* 682:virus* 451:Toxins 60:toxins 30:Under 1840:(DoD) 1834:(CDC) 1808:(DoD) 1786:(CDC) 1589:(CDC) 1583:(CDC) 1523:State 1507:Local 1472:/DHS) 1462:(HHS) 1454:NIAID 1452:(HHS/ 1444:NIAID 947:pauca 704:virus 676:virus 663:virus 657:virus 607:virus 488:Ricin 464:Abrin 1931:MOPP 1885:and 1883:NIMS 1812:RODS 1743:and 1601:Non- 1565:USMC 1555:NDMS 1480:USDA 1440:UTMB 1281:DHHS 1092:2021 1013:News 788:zeae 786:var 83:FSAP 40:BSAT 2234:DoD 2014:Law 1887:ICS 1575:CDC 1470:EPA 1314:DoD 1298:CDC 1262:DNI 1219:DHS 167:OIG 75:SAP 2337:: 1380:, 1154:. 1141:. 1082:. 1033:, 1008:, 339:: 141:. 101:. 34:, 2236:) 2232:( 1889:) 1670:) 1655:) 1651:( 1640:) 1636:( 1577:) 1573:( 1567:) 1563:( 1553:( 1482:) 1478:( 1468:( 1456:) 1446:) 1442:/ 1438:( 1384:) 1376:( 1300:) 1296:( 1238:) 1187:e 1180:t 1173:v 1145:. 1094:. 1055:. 949:( 778:) 766:) 762:( 584:) 572:) 539:* 471:* 431:) 427:( 391:* 375:* 269:* 247:* 239:) 227:) 208:* 81:( 73:( 38:( 20:)

Index

Select Agent
United States law
bio-agents
U.S. Department of Health and Human Services
U.S. Department of Agriculture
toxins
Centers for Disease Control and Prevention
USA PATRIOT Act
Public Health Security and Bioterrorism Preparedness and Response Act of 2002
September 11, 2001 attacks
2001 anthrax attacks
dual use
National Science Advisory Board for Biosecurity
life science
USA PATRIOT Act
Public Health Security and Bioterrorism Preparedness and Response Act of 2002
September 11, 2001 attacks
2001 anthrax attacks
dual use
National Science Advisory Board for Biosecurity
life science
OIG
Division of Select Agents and Toxins
neurotoxin
Clostridium
Coxiella burnetii
Burkholderia mallei
Burkholderia pseudomallei
Francisella tularensis
Rickettsia prowazekii

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