Knowledge (XXG)

Select agent

Source đź“ť

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Bioterrorism Act of 2002, the OIG had received 68 referrals from the CDC for possible Select Agent enforcement and found violations in 30 of those cases. Notices of violation were sent to 5 federal entities, 3 universities, and 2 other private organizations, all unnamed in his testimony. Demske remarked that no federal agencies had been fined for SAP violations.
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detects possible SAP misconduct by an HHS worker, it coordinates with the OIG to gather facts. If it concludes that a civil violation might have occurred, it turns the case over to the OIG for possible enforcement. But if it suspects a crime, it pursues the matter with the FBI. Since passage of the
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Select agent regulations were revised in October 2012 to designate thirteen "Tier 1" agents with a documented risk of causing a high consequence event higher than other BSATs. Criteria for Tier 1 status were (1) Ability to produce a mass casualty event or devastating effects to the economy; (2)
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research. It is composed of government, education and industry experts who provide policy recommendations on ways to minimize the possibility that knowledge and technologies emanating from biological research will be misused to threaten public health or national security.
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research. It is composed of government, education and industry experts who provide policy recommendations on ways to minimize the possibility that knowledge and technologies emanating from biological research will be misused to threaten public health or national security.
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Communicability; (3) Low infectious dose; and (4) History of or current interest in weaponization based on threat reporting. In the same revision Chapare virus, Lujo virus, and SARS-associated coronavirus (SARS-CoV) were added to the list of select agents.
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National Research Council (US) Committee on Laboratory Security and Personnel Reliability Assurance Systems for Laboratories Conducting Research on Biological Select Agents and Toxins. (2009). "Chapter 1. Introduction".
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Criteria for removal from the BSAT list were (1) Low potential for causing mortality; (2) Endemicity in the U.S. (animal agents); and (3) Difficulty in producing quantities necessary for high consequence
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The CDC has regulated the laboratories which may possess, use, or transfer select agents within the United States under the SAP since 2001. The SAP was established to satisfy requirements of the
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and toxins are considered to "have the potential to pose a severe threat to both human and animal health, to plant health, or to animal and plant products".
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A federal advisory committee that addresses issues related to biosecurity and dual use research at the request of the United States Government.
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Select agent regulations were revised in October 2012 to remove 19 BSATs from the list (7 Human and Overlap Agents and 12 Animal Agents).
47:(USDA) to have the "potential to pose a severe threat to public health and safety". The agents are divided into (1) HHS select agents and 2222: 1871: 1403: 2073: 1428: 1207: 2123: 1767: 1632: 1617: 1464: 1250: 822: 282: 51:
affecting humans; (2) USDA select agents and toxins affecting agriculture; and (3) overlap select agents and toxins affecting both.
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In July 2015, Gregory E. Demske, chief counsel to the inspector general in the HHS Office of Inspector General (
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Middle-Atlantic Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research
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Global Partnership Against the Spread of Weapons and Materials of Mass Destruction
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virus containing any portion of the coding regions of all eight gene segments.
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Additional Requirements for Facilities Transferring or Receiving Select Agents
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Public Health Security and Bioterrorism Preparedness and Response Act of 2002
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Public Health Security and Bioterrorism Preparedness and Response Act of 2002
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Johns Hopkins Center for Health Security (formerly Center for Biosecurity)
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Statement on Chemical and Biological Defense Policies and Programs
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Using select agents in biomedical research prompts concerns about
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Pandemic and All-Hazards Preparedness Reauthorization Act of 2013
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Public Health Security and Bioterrorism Preparedness Response Act
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Joint Program Executive Office of Chemical and Biological Defense
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This refers to reconstructed, replication-competent forms of the
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Biodefense and Pandemic Vaccine and Drug Development Act of 2005
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Integrated National Biodefense Medical Countermeasures Portfolio
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Office of the Assistant Secretary for Preparedness and Response
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National Medical Response Team/National Pharmacy Response Team
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Responsible Research with Biological Select Agents and Toxins
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Joint Biological Agent Identification and Diagnostic System
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Bioterror Rapid Response and Advanced Technology Laboratory
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U.S. Army Medical Research Institute of Infectious Diseases
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Global Emerging Infections Surveillance and Response System
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National Interagency Confederation for Biological Research
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Using BSATs in biomedical research prompts concerns about
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small colony (Mmm SC) (contagious bovine pleuropneumonia)
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National Intelligence Assessments on Infectious Diseases
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Johns Hopkins Center for Civilian Biodefense Strategies
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National Biodefense Analysis and Countermeasures Center
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National Center for Biodefense and Infectious Diseases
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Biomedical Advanced Research and Development Authority
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United States Department of Health and Human Services
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Washington DC: National Academies Press. 56:Centers for Disease Control and Prevention 2096:Pandemic and All-Hazards Preparedness Act 1570:Aeromedical Biological Containment System 1524:Nebraska Biocontainment Patient Care Unit 1399:Defense Advanced Research Projects Agency 1311:Assistant SECDEF for NCB Defense Programs 430:Sabiá virus (Brazilian hemorrhagic fever) 297:Far-Eastern tick-borne encephalitis virus 2209:United States biological weapons program 1332:National Center for Medical Intelligence 1184:United States biological defense program 122:, which were enacted in the wake of the 82:, which were enacted in the wake of the 1868:National Strategy for Homeland Security 1016:Department of Health and Human Services 974: 350:Viral hemorrhagic fever (VHF) viruses: 1367:National Interagency Biodefense Campus 1236:National Bio and Agro-Defense Facility 1638:Center for Biodefense Immune Modeling 1073:CDC/USDA Federal Select Agent Program 357:Crimean–Congo hemorrhagic fever virus 137:. The federal government created the 97:. The federal government created the 7: 1956:Autonomous Pathogen Detection System 1283:Division of Select Agents and Toxins 1261:(Advisory Committee on Bioterrorism) 1259:National Counterproliferation Center 1241:National Bioforensic Analysis Center 909:(contagious caprine pleuropneumonia) 840:Venezuelan equine encephalitis virus 285:(excluding South American genotypes) 160:Division of Select Agents and Toxins 1404:Edgewood Chemical Biological Center 1789:Bio-Surveillance Management Office 1455:Homeland Security Research Program 25:Biological select agents or toxins 14: 2124:Global Health Security Initiative 1768:National Biosurveillance Strategy 1465:Plum Island Animal Disease Center 823:Eastern equine encephalitis virus 283:Eastern equine encephalitis virus 2254:Biosecurity in the United States 2160:1984 Rajneeshee bioterror attack 1990:Positive pressure personnel suit 1882:National Disaster Medical System 958:Biosecurity in the United States 892:(Alcelaphine herpesvirus type 1) 748:Peronosclerospora philippinensis 680:Peste des petits ruminants virus 513:Overlap select agents and toxins 2309:Smallpox virus retention debate 2204:United States Army Medical Unit 1730:Defense Threat Reduction Agency 1316:Defense Threat Reduction Agency 1069:"Select Agents and Toxins List" 963:U.S. biological defense program 890:Malignant Catarrhal Fever virus 834:Tick-borne encephalitis viruses 863:Bovine spongiform encephalitis 741:Fungi or fungus-like pathogens 600:Venezuelan equine encephalitis 101:which promotes biosecurity in 45:U.S. Department of Agriculture 1: 2165:1989 California medfly attack 2029:Biological Weapons Convention 1827:Personnel Reliability Program 1560:Epidemic Intelligence Service 1425:Galveston National Laboratory 842:, enzootic subtypes ID and IE 607:USDA select agents and toxins 389:Kyasanur Forest disease virus 1888:Strategic National Stockpile 1439:Integrated Research Facility 1221:DHS Office of Health Affairs 1132:Federal Select Agent Program 790:List of former select agents 426:(Bolivian hemorrhagic fever) 400:South American VHF viruses: 394:Omsk hemorrhagic fever virus 177:HHS select agents and toxins 68:Federal Select Agent Program 1951:Biological Materials MASINT 1864:National Response Framework 1773:Laboratory Response Network 1734:Biological Threat Reduction 1678:Battelle Memorial Institute 940:citrus variegated chlorosis 885:Japanese encephalitis virus 487:Staphylococcal enterotoxins 418:Argentine hemorrhagic fever 272:SARS-associated coronavirus 2356: 2219:Aeromedical Isolation Team 1030:Government Printing Office 825:, South American genotypes 753:Peronosclerospora sacchari 141:to promote biosecurity in 124:September 11, 2001 attacks 84:September 11, 2001 attacks 658:virus (highly pathogenic) 566:Burkholderia pseudomallei 496:2 Type A trichothecenes: 221:Burkholderia pseudomallei 1791:(BMO) (part of JPEO-CBD) 1519:State Health Departments 1503:Local Health Departments 1145:Office of Science Policy 798:Human and overlap agents 783:Synchytrium endobioticum 675:Lumpy skin disease virus 571:Pseudomonas pseudomallei 226:Pseudomonas pseudomallei 2299:Isolation (health care) 2269:Biological warfare (BW) 1642:University of Rochester 1613:Henry L. Stimson Center 691:Swine vesicular disease 465:Clostridium perfringens 444:As of April 2021 these 289:Tick-borne encephalitis 810:Coccidioides posadasii 772:Sclerophthora rayssiae 719:Ralstonia solanacearum 669:Foot-and-mouth disease 644:African horse sickness 279:Encephalitis viruses: 233:Francisella tularensis 191:-producing species of 2294:Entomological warfare 2195:Defunct organizations 2175:Wood Green ricin plot 2079:Project Bioshield Act 2056:Executive Order 13139 1409:Dugway Proving Ground 993:Roos, Robert (2015), 902:Mycoplasma capricolum 765:Pyrenochaeta glycines 727:Rathayibacter toxicus 458:Botulinum neurotoxins 353:African VHF viruses: 248:Rickettsia rickettsii 241:Rickettsia prowazekii 167:List of select agents 2170:2001 anthrax attacks 1838:Medical intelligence 1821:Select Agent Program 1745:Project Clear Vision 918:Vesicular stomatitis 874:Erlichia ruminantium 817:Coccidioides immitis 319:1918 influenza virus 128:2001 anthrax attacks 88:2001 anthrax attacks 60:Select Agent Program 836:, European subtypes 650:African swine fever 626:Mycoplasma mycoides 554:Burkholderia mallei 540:Brucella melitensis 385:Asian VHF viruses: 343:Variola minor virus 337:Variola major virus 209:Burkholderia mallei 126:and the subsequent 86:and the subsequent 2186:2013 ricin letters 2181:2003 ricin letters 1728:, implemented the 1657:George Mason Univ. 932:Xylella fastidiosa 734:Xanthomonas oryzae 559:Pseudomonas mallei 525:Bacillus anthracis 500:Diacetoxyscirpenol 339:* (smallpox virus) 308:Influenza viruses: 214:Pseudomonas mallei 66:)—also called the 2317: 2316: 2264:Biological hazard 2232: 2231: 2110: 2109: 1998: 1997: 1985:Biosafety cabinet 1897: 1896: 1856:Disaster response 1750:Project Jefferson 1705: 1704: 1701: 1700: 1683:SRI International 1585: 1584: 1484: 1483: 1340: 1339: 1056:1918 flu pandemic 760:Phoma glycinicola 698:Newcastle disease 594:Rift Valley fever 446:biological agents 368:Lassa fever virus 202:Coxiella burnetii 21:United States law 2347: 2259:Biological agent 2214:Sunshine Project 2148: 2007: 1908: 1870:(DHS; including 1719:Threat reduction 1716: 1688:Idaho Technology 1627:Brown University 1599:Academic centers 1596: 1493: 1351: 1204: 1195: 1177: 1170: 1163: 1154: 1148: 1135: 1116: 1095: 1091: 1085: 1084: 1082: 1080: 1065: 1059: 1052: 1046: 1045: 1038: 1032: 1025:Federal Register 1011: 1005: 1004:(18 July issue). 991: 985: 979: 953:Biological agent 858:Bluetongue virus 722:race 3, biovar 2 533:Brucella abortus 118:of 2001 and the 78:of 2001 and the 43:(HHS) or by the 2355: 2354: 2350: 2349: 2348: 2346: 2345: 2344: 2320: 2319: 2318: 2313: 2289:Decontamination 2274:Biosurveillance 2228: 2196: 2190: 2152: 2151:Past biological 2139: 2116: 2106: 2034: 2017:Geneva Protocol 1994: 1980:Biosafety level 1966: 1934: 1903: 1893: 1850: 1832: 1806: 1760:Biosurveillance 1754: 1740:Project Bacchus 1711: 1697: 1669: 1662: 1601:and think tanks 1600: 1591: 1581: 1528: 1507: 1480: 1413: 1382: 1355: 1346: 1336: 1297: 1264: 1245: 1199: 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954: 951: 950: 946: 941: 937: 934: 933: 929: 928: 924: 919: 916: 914: 911: 908: 904: 903: 899: 897: 894: 891: 888: 886: 883: 881: 878: 876: 875: 871: 869: 866: 864: 861: 859: 856: 854: 853:Akabane virus 851: 850: 847:Animal agents 846: 841: 838: 835: 832: 830: 827: 824: 821: 819: 818: 814: 812: 811: 807: 805: 802: 801: 797: 795: 789: 785: 784: 780: 778: 774: 773: 769: 766: 762: 761: 757: 754: 750: 749: 745: 744: 740: 736: 735: 731: 729: 728: 724: 721: 720: 716: 715: 711: 707: 704: 699: 695: 692: 689: 686: 683: 681: 678: 676: 673: 670: 667: 664: 660: 657: 654: 651: 648: 645: 642: 641: 637: 632: 628: 627: 623: 622: 618: 614: 611: 606: 601: 598: 595: 592: 590: 587: 585: 582: 581: 577: 572: 568: 567: 563: 560: 556: 555: 551: 549: 548: 547:Brucella suis 544: 542: 541: 537: 535: 534: 530: 527: 526: 522: 521: 517: 512: 506: 503: 501: 498: 497: 495: 493: 490: 488: 485: 483: 480: 478: 475: 473: 470: 468:epsilon toxin 467: 466: 462: 459: 456: 454: 451: 450: 449: 447: 439: 431: 428: 425: 422: 419: 415: 412: 410: 407: 405: 404:Chapare virus 402: 401: 399: 395: 392: 390: 387: 386: 384: 379: 378:Marburg virus 376: 374: 371: 369: 366: 363: 360: 358: 355: 354: 352: 351: 349: 344: 341: 338: 335: 333: 330: 329: 327: 324: 320: 316: 314: 311: 310: 309: 306: 299: 296: 293: 292: 290: 287: 284: 281: 280: 278: 273: 270: 269: 268:Coronavirus: 267: 266: 262: 257: 256: 252: 250: 249: 245: 243: 242: 238: 235: 234: 230: 227: 223: 222: 218: 215: 211: 210: 206: 204: 203: 199: 196: 195: 190: 186: 185: 181: 176: 171: 170: 166: 164: 161: 157: 149: 147: 144: 140: 136: 131: 129: 125: 121: 117: 109: 107: 104: 100: 96: 91: 89: 85: 81: 77: 73: 69: 65: 61: 57: 52: 50: 46: 42: 38: 34: 33:select agents 31:s)—or simply 30: 26: 22: 2304:Select agent 2303: 2284:CBRN defense 2279:Bioterrorism 2197:and programs 2019:(1925, 1975) 1712:and projects 1592:governmental 1371:Fort Detrick 1356:departmental 1144: 1131: 1111: 1089: 1077:. Retrieved 1072: 1063: 1050: 1036: 1023: 1009: 998: 989: 981: 977: 935: 930: 925:Plant agents 906: 900: 872: 829:Flexal virus 815: 808: 793: 781: 776: 770: 764: 758: 752: 746: 732: 725: 717: 705: 630: 624: 612: 584:Hendra virus 570: 569:* (formerly 564: 558: 557:* (formerly 552: 545: 538: 531: 523: 492:Tetrodotoxin 463: 443: 345:* (Alastrim) 307: 253: 246: 239: 231: 225: 224:* (formerly 219: 213: 212:* (formerly 207: 200: 192: 153: 143:life science 132: 113: 103:life science 92: 71: 67: 63: 59: 53: 32: 28: 24: 18: 2340:Biosecurity 2062:Patriot Act 2039:Legislation 1946:Cell CANARY 1930:Respirators 1812:Biosecurity 1693:Phoenix Air 1670:contractors 905:subspecies 663:swine fever 629:subspecies 613:For animals 589:Nipah virus 414:Junin virus 362:Ebola virus 194:Clostridium 2324:Categories 2249:Biodefense 1912:Protection 1902:Technology 1890:(CDC, DHS) 1814:/Biosurety 1803:(Civilian) 1781:(EPA, CDC) 1736:(DoD) plus 1668:Government 1379:(DHHS/DoD) 1328:(JPEO-CBD) 969:References 763:(formerly 706:For plants 685:Rinderpest 661:Classical 472:Conotoxins 373:Lujo virus 274:(SARS-CoV) 189:neurotoxin 187:Botulinum 150:Violations 110:Regulation 37:bio-agents 2153:incidents 1939:Detection 696:Virulent 505:T-2 toxin 482:Saxitoxin 54:The U.S. 2010:Treaties 1963:(JBAIDS) 1925:NBC suit 1787:(GBTI), 1779:BioWatch 1710:Programs 1655:(NCBID; 1489:Response 1418:Civilian 1387:Military 1347:research 1225:BioWatch 1079:27 April 1018:(2012), 947:See also 712:Bacteria 631:mycoides 619:Bacteria 518:Bacteria 182:Bacteria 135:dual use 95:dual use 2144:History 1866:of the 1795:ESSENCE 1533:Federal 1345:Federal 1198:Federal 942:strain) 700:virus 1 638:Viruses 578:Viruses 424:Machupo 263:Viruses 2335:Toxins 2177:(2002) 2136:(2004) 2098:(2006) 2092:(2005) 2081:(2004) 2070:(2002) 2064:(2001) 2058:(1999) 2031:(1972) 2025:(1969) 1884:(DHHS) 1546:, HHS) 1477:(USDA) 1354:Trans- 1128:"Home" 1094:event. 1000:CIDRAP 687:virus* 671:virus* 440:Toxins 49:toxins 19:Under 1829:(DoD) 1823:(CDC) 1797:(DoD) 1775:(CDC) 1578:(CDC) 1572:(CDC) 1512:State 1496:Local 1461:/DHS) 1451:(HHS) 1443:NIAID 1441:(HHS/ 1433:NIAID 936:pauca 693:virus 665:virus 652:virus 646:virus 596:virus 477:Ricin 453:Abrin 1920:MOPP 1874:and 1872:NIMS 1801:RODS 1732:and 1590:Non- 1554:USMC 1544:NDMS 1469:USDA 1429:UTMB 1270:DHHS 1081:2021 1002:News 777:zeae 775:var 72:FSAP 29:BSAT 2223:DoD 2003:Law 1876:ICS 1564:CDC 1459:EPA 1303:DoD 1287:CDC 1251:DNI 1208:DHS 156:OIG 64:SAP 2326:: 1369:, 1143:. 1130:. 1071:. 1022:, 997:, 328:: 130:. 90:. 23:, 2225:) 2221:( 1878:) 1659:) 1644:) 1640:( 1629:) 1625:( 1566:) 1562:( 1556:) 1552:( 1542:( 1471:) 1467:( 1457:( 1445:) 1435:) 1431:/ 1427:( 1373:) 1365:( 1289:) 1285:( 1227:) 1176:e 1169:t 1162:v 1134:. 1083:. 1044:. 938:( 767:) 755:) 751:( 573:) 561:) 528:* 460:* 420:) 416:( 380:* 364:* 258:* 236:* 228:) 216:) 197:* 70:( 62:( 27:(

Index

United States law
bio-agents
U.S. Department of Health and Human Services
U.S. Department of Agriculture
toxins
Centers for Disease Control and Prevention
USA PATRIOT Act
Public Health Security and Bioterrorism Preparedness and Response Act of 2002
September 11, 2001 attacks
2001 anthrax attacks
dual use
National Science Advisory Board for Biosecurity
life science
USA PATRIOT Act
Public Health Security and Bioterrorism Preparedness and Response Act of 2002
September 11, 2001 attacks
2001 anthrax attacks
dual use
National Science Advisory Board for Biosecurity
life science
OIG
Division of Select Agents and Toxins
neurotoxin
Clostridium
Coxiella burnetii
Burkholderia mallei
Burkholderia pseudomallei
Francisella tularensis
Rickettsia prowazekii
Rickettsia rickettsii

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