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SNARF-1 can serve as a substrate for the MRP1 (multidrug resistance-associated protein-1) drug transporter, to measure the activity of the MRP1 transporter. For this purpose, an acetomethoxyester group is added to SNARF-1. Cellular esterases cleave off SNARF-1, and its transport out of the cells can
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Weekes, M. P.; Tan, S. Y. L.; Poole, E.; Talbot, S.; Antrobus, R.; Smith, D. L.; Montag, C.; Gygi, S. P.; Sinclair, J. H.; Lehner, P. J. (12 April 2013).
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InChI=1S/C24H15NO4/c25-14-6-10-19-21(12-14)28-22-16-8-7-15(26)11-13(16)5-9-20(22)24(19)18-4-2-1-3-17(18)23(27)29-24/h1-12,26H,25H2
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Except where otherwise noted, data are given for materials in their
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be measured by following the loss of fluorescence from the cells.
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O=C(O1)C2=C(C=CC=C2)C31C4=CC=C(N)C=C4OC5=C3C=CC6=C5C=CC(O)=C6
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585 nm, while that at pH 9.0 is at 640 nm.
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140:Seminaphtharhodafluorescein; Seminaphthorhodafluor
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311:Key: DYPYMMHZGRPOCK-UHFFFAOYSA-N
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456:of carboxy-SNARF at pH 6.0 is at
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119:Seminaphtharhodafluor
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