Knowledge (XXG)

Serum sickness

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should make their patients aware of the drugs or antitoxins to which they are allergic if there is a reaction. The physician will then choose an alternate antitoxin if it is appropriate, or continue with prophylactic measures. This is important if a patient has received an antitoxin before, as the
387:. The body produces antibodies, which combine with these proteins to form immune complexes. These complexes precipitate, enter the walls of blood vessels, and activate the complement cascade, initiating an inflammatory response and consuming much of the available 1313: 1298: 718:
can also cause serum sickness. However, according to the Johns Hopkins Bloomberg School of Public Health, routinely recommended vaccinations to the general population in the U.S have not been shown to cause serum sickness, as of 2012.
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Signs and symptoms can take as long as 14 days after exposure to appear. They may include signs and symptoms commonly associated with hypersensitivity or infections. Common symptoms include:
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that may cause serum sickness is the best way to prevent serum sickness. Sometimes, the benefits of using an antitoxin outweigh the risks in the case of a life-threatening
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or drug treatment should be stopped as soon as possible. Once treatment has stopped, symptoms usually resolve within seven days. Outcomes are generally good.
1658: 1944: 1668: 1541: 2520: 2515: 2116: 2471: 403:, a low C3 level in serum. They can also cause more reactions, causing the typical symptoms of serum sickness. This is similar to a generalised 2293: 1684: 1653: 1165: 1115: 1043: 1679: 1413: 213:(SSLR) is occasionally used to refer to similar illnesses that arise from the introduction of certain non-protein substances, such as 1197:"Serum sickness following rabbit antithymocyte-globulin induction in a liver transplant recipient: case report and literature review" 2510: 2288: 1696: 601: 491: 210: 2147: 2283: 2329: 2191: 531: 473: 202: 2186: 352: 875:
Serum sickness is becoming less common over time. Many drugs based on animal serum have been replaced with artificial drugs.
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may be used beforehand in order to identify individuals who may be at risk of a reaction.
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are the main line of treatment. The choice depends on the severity of the reaction.
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Diagnosis is based on history given by patient, including recent medications. A
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source, occurring 5–10 days after exposure. Symptoms often include a
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Rarely, serum sickness can have severe complications. These include
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Serum sickness may be diagnosed based on the symptoms, and using a
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Pediatric Clinical Advisor - Instant Diagnosis and Treatment
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serum sickness caused can be worse and occur more quickly.
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Lundquist AL, Chari RS, Wood JH, et al. (May 2007).
932:"Serum sickness-like reaction associated with cefazolin" 618:. Some of the drugs associated with serum sickness are: 1280: 2493: 2459: 2450: 2428: 2382: 2361: 2342: 2312: 2266: 2251: 2210: 2162: 2155: 2141: 2111: 2086: 2001: 1978: 1705: 1637: 1594: 1555: 1519: 1440: 1354: 1284: 154: 130: 122: 107: 87: 73: 62: 41: 29: 24: 415:Serum sickness is usually a result of exposure to 2438:Transfusion-associated graft-versus-host disease 1664:Transfusion-associated graft versus host disease 1018:Paizis, Ekaterini; Murphy, Brendan F. (1998). 1952: 1414: 614:Serum sickness may be caused by some routine 8: 1236:Jackson R (October 2000). "Serum sickness". 1659:Transfusion associated circulatory overload 538:. Unsourced material may be challenged and 423:are generally given to prevent or treat an 289:), particularly near the site of injection. 2558:Complications of surgical and medical care 2456: 2358: 2263: 2159: 2138: 1998: 1959: 1945: 1937: 1669:Febrile non-hemolytic transfusion reaction 1542:International Society of Blood Transfusion 1421: 1407: 1399: 1281: 930:Brucculeri M, Charlton M, Serur D (2006). 883:Serum sickness was first characterized by 79:symptoms, blood test (low cell counts and 21: 1212: 957: 947: 766:may be taken and tested, which will show 731:may be taken and tested, which will show 602:Learn how and when to remove this message 492:Learn how and when to remove this message 2472:Allergic bronchopulmonary aspergillosis 922: 786:Similar skin symptoms may be caused by 273:), especially in finger and toe joints. 244:. It was first characterized in 1906. 2294:Post-streptococcal glomerulonephritis 1654:Transfusion related acute lung injury 1085: 1083: 1081: 1079: 1077: 1075: 1013: 1011: 1009: 1007: 1005: 1003: 1001: 999: 997: 7: 1135: 1133: 1131: 1129: 1127: 1073: 1071: 1069: 1067: 1065: 1063: 1061: 1059: 1057: 1055: 995: 993: 991: 989: 987: 985: 983: 981: 979: 977: 536:adding citations to reliable sources 419:derived from animals. These sera or 395:. The result is a leukocytoclastic 111:not using antitoxins, prophylactic 465:Remarkably similar to the list in 14: 2511:Autoimmune polyendocrine syndrome 1697:Transfusion transmitted infection 2148:Hemolytic disease of the newborn 1158:10.1016/B978-141600087-7.50104-5 1108:10.1016/B978-032303506-4.10296-2 1090:Copenhaven, Christopher (2007). 508: 443: 2330:Subacute bacterial endocarditis 2192:Immune thrombocytopenic purpura 822:may be used with an antitoxin. 203:immune complex hypersensitivity 1: 2410:Postorgasmic illness syndrome 1394:Serum sickness-like reactions 860:may be used in severe cases. 2467:Hypersensitivity pneumonitis 1586:Intraoperative blood salvage 1146:Pediatric Emergency Medicine 911:Serum sickness-like reaction 467:serum sickness-like reaction 393:serum sickness-like reaction 211:serum sickness–like reaction 2533:Systemic autoimmune disease 2369:Allergic contact dermatitis 2289:Hypersensitivity vasculitis 2172:Autoimmune hemolytic anemia 1602:Blood compatibility testing 463:. The specific problem is: 2574: 2039:common allergies include: 1250:10.1177/120347540000400411 1024:Encyclopedia of Immunology 774:(blood in the urine, with 459:to meet Knowledge (XXG)'s 1649:Transfusion hemosiderosis 1140:Benjamin, Lee S. (2008). 867:has also been described. 747:), high sedimentation of 365:type III hypersensitivity 177:derived from a non-human 58:(swelling of lymph nodes) 2284:Henoch–Schönlein purpura 2099:Eosinophilic esophagitis 1629:Monocyte monolayer assay 751:, and a decrease in the 323:), and in serious cases 240:, and (in severe cases) 2400:Hashimoto's thyroiditis 2187:Guillain–BarrĂ© syndrome 1504:Granulocyte transfusion 814:or sting. Prophylactic 411:Antitoxins and antisera 353:Guillain–BarrĂ© syndrome 299:Other symptoms include 2501:Autoimmune adrenalitis 1142:"101 - Serum Sickness" 1036:10.1006/rwei.1999.0547 1030:. pp. 2168–2170. 782:Differential diagnosis 389:complement component 3 266:itching and urticaria. 126:resolves spontaneously 89:Differential diagnosis 1639:Transfusion reactions 949:10.1186/1472-6904-6-3 710:Allergenic extracts, 2506:Autoimmune hepatitis 2485:Transplant rejection 2395:Giant cell arteritis 2325:Rheumatoid arthritis 2182:Goodpasture syndrome 2094:Autoimmune urticaria 1619:Kleihauer–Betke test 1581:Exchange transfusion 1460:Platelet transfusion 1434:transfusion medicine 1152:. pp. 741–743. 532:improve this section 474:improve this section 383:present for harmful 375:is given, the human 367:reaction, caused by 363:Serum sickness is a 1972:autoimmune diseases 1707:Blood group systems 1642:and adverse effects 1477:Fresh frozen plasma 885:Clemens von Pirquet 792:erythema multiforme 753:complement proteins 98:erythema multiforme 83:counts), urine test 2415:Reactive arthritis 2405:Multiple sclerosis 2299:Reactive arthritis 2197:Pemphigus vulgaris 2177:Bullous pemphigoid 2078:Penicillin allergy 2014:Allergic urticaria 1355:External resources 936:BMC Clin Pharmacol 401:hypocomplementemia 399:. This results in 305:blood in the urine 301:glomerulonephritis 248:Signs and symptoms 197:. It is a type of 81:complement protein 2545: 2544: 2541: 2540: 2446: 2445: 2338: 2337: 2247: 2246: 2243: 2242: 2235:Pernicious anemia 2230:Myasthenia gravis 2107: 2106: 2030:Atopic dermatitis 2019:Allergic rhinitis 1934: 1933: 1511:Blood substitutes 1499:White blood cells 1430:Blood transfusion 1389: 1388: 1167:978-1-4160-0087-7 1117:978-0-323-03506-4 1045:978-0-12-226765-9 745:white blood cells 612: 611: 604: 586: 502: 501: 494: 461:quality standards 452:This section may 431:(venomous bite). 325:circulatory shock 164: 163: 75:Diagnostic method 19:Medical condition 16:Medical condition 2565: 2528:Sjögren syndrome 2457: 2359: 2264: 2160: 2139: 1999: 1968:Hypersensitivity 1961: 1954: 1947: 1938: 1624:Antibody elution 1571:plateletpheresis 1537:Blood management 1520:General concepts 1423: 1416: 1409: 1400: 1282: 1270: 1269: 1238:J Cutan Med Surg 1233: 1227: 1226: 1216: 1214:10.1002/lt.21098 1192: 1186: 1185: 1178: 1172: 1171: 1137: 1122: 1121: 1098:(2nd ed.). 1092:"Serum Sickness" 1087: 1050: 1049: 1026:(2nd ed.). 1020:"Serum Sickness" 1015: 972: 971: 961: 951: 927: 901:Hypersensitivity 770:, and sometimes 733:thrombocytopenia 607: 600: 596: 593: 587: 585: 551:"Serum sickness" 544: 512: 504: 497: 490: 486: 483: 477: 447: 446: 439: 379:can mistake the 369:immune complexes 345:laryngeal oedema 199:hypersensitivity 22: 2573: 2572: 2568: 2567: 2566: 2564: 2563: 2562: 2548: 2547: 2546: 2537: 2489: 2452: 2442: 2424: 2420:Type 1 diabetes 2390:Coeliac disease 2378: 2350: 2334: 2308: 2274:Arthus reaction 2255: 2239: 2225:Graves' disease 2206: 2202:Rheumatic fever 2151: 2119: 2103: 2082: 2009:Allergic asthma 1990: 1974: 1965: 1935: 1930: 1725:Secretor status 1701: 1641: 1633: 1590: 1551: 1515: 1492:Cryosupernatant 1487:Cryoprecipitate 1467:Red blood cells 1436: 1427: 1390: 1385: 1384: 1350: 1349: 1293: 1279: 1274: 1273: 1235: 1234: 1230: 1194: 1193: 1189: 1180: 1179: 1175: 1168: 1139: 1138: 1125: 1118: 1102:. p. 518. 1089: 1088: 1053: 1046: 1017: 1016: 975: 929: 928: 924: 919: 906:Arthus reaction 897: 881: 873: 846:Corticosteroids 837: 820:corticosteroids 804: 784: 749:red blood cells 725: 708: 703: 608: 597: 591: 588: 545: 543: 529: 513: 498: 487: 481: 478: 471: 448: 444: 437: 413: 405:Arthus reaction 361: 333: 283:lymphadenopathy 250: 234:corticosteroids 201:, specifically 195:lymphadenopathy 173:to proteins in 169:in humans is a 137:corticosteroids 117:corticosteroids 56:lymphadenopathy 20: 17: 12: 11: 5: 2571: 2569: 2561: 2560: 2550: 2549: 2543: 2542: 2539: 2538: 2536: 2535: 2530: 2525: 2524: 2523: 2518: 2508: 2503: 2497: 2495: 2491: 2490: 2488: 2487: 2482: 2476: 2475: 2474: 2463: 2461: 2454: 2448: 2447: 2444: 2443: 2441: 2440: 2434: 2432: 2426: 2425: 2423: 2422: 2417: 2412: 2407: 2402: 2397: 2392: 2386: 2384: 2380: 2379: 2377: 2376: 2371: 2365: 2363: 2356: 2340: 2339: 2336: 2335: 2333: 2332: 2327: 2322: 2316: 2314: 2310: 2309: 2307: 2306: 2304:Serum sickness 2301: 2296: 2291: 2286: 2281: 2276: 2270: 2268: 2261: 2258:Immune complex 2249: 2248: 2245: 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1550: 1549: 1544: 1539: 1534: 1532:Blood donation 1529: 1523: 1521: 1517: 1516: 1514: 1513: 1508: 1507: 1506: 1496: 1495: 1494: 1489: 1484: 1479: 1469: 1464: 1463: 1462: 1452: 1446: 1444: 1442:Blood products 1438: 1437: 1428: 1426: 1425: 1418: 1411: 1403: 1397: 1396: 1387: 1386: 1383: 1382: 1371: 1359: 1358: 1356: 1352: 1351: 1348: 1347: 1336: 1325: 1310: 1294: 1289: 1288: 1286: 1285:Classification 1278: 1277:External links 1275: 1272: 1271: 1228: 1187: 1173: 1166: 1123: 1116: 1051: 1044: 1028:Academic Press 973: 921: 920: 918: 915: 914: 913: 908: 903: 896: 893: 880: 877: 872: 869: 865:plasmapheresis 850:antihistamines 836: 833: 816:antihistamines 803: 800: 783: 780: 776:hemoglobinuria 724: 721: 707: 704: 702: 701: 696: 691: 686: 681: 676: 671: 666: 661: 656: 651: 646: 641: 639:cephalosporins 636: 631: 626: 620: 610: 609: 516: 514: 507: 500: 499: 451: 449: 442: 436: 433: 412: 409: 360: 357: 332: 329: 321:blood pressure 297: 296: 290: 280: 274: 267: 264: 249: 246: 230:antihistamines 167:Serum sickness 162: 161: 158: 152: 151: 141:antihistamines 134: 128: 127: 124: 120: 119: 113:antihistamines 109: 105: 104: 91: 85: 84: 77: 71: 70: 64: 60: 59: 50:, joint pain, 45: 39: 38: 33: 27: 26: 25:Serum sickness 18: 15: 13: 10: 9: 6: 4: 3: 2: 2570: 2559: 2556: 2555: 2553: 2534: 2531: 2529: 2526: 2522: 2519: 2517: 2514: 2513: 2512: 2509: 2507: 2504: 2502: 2499: 2498: 2496: 2492: 2486: 2483: 2480: 2479:Latex allergy 2477: 2473: 2470: 2469: 2468: 2465: 2464: 2462: 2458: 2455: 2449: 2439: 2436: 2435: 2433: 2431: 2427: 2421: 2418: 2416: 2413: 2411: 2408: 2406: 2403: 2401: 2398: 2396: 2393: 2391: 2388: 2387: 2385: 2381: 2375: 2372: 2370: 2367: 2366: 2364: 2360: 2357: 2354: 2349: 2348:cell-mediated 2345: 2341: 2331: 2328: 2326: 2323: 2321: 2318: 2317: 2315: 2311: 2305: 2302: 2300: 2297: 2295: 2292: 2290: 2287: 2285: 2282: 2280: 2279:Farmer's lung 2277: 2275: 2272: 2271: 2269: 2265: 2262: 2259: 2254: 2250: 2236: 2233: 2231: 2228: 2226: 2223: 2222: 2220: 2218: 2214: 2209: 2203: 2200: 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1247: 1243: 1239: 1232: 1229: 1224: 1220: 1215: 1210: 1207:(5): 647–50. 1206: 1202: 1201:Liver Transpl 1198: 1191: 1188: 1183: 1177: 1174: 1169: 1163: 1159: 1155: 1151: 1147: 1143: 1136: 1134: 1132: 1130: 1128: 1124: 1119: 1113: 1109: 1105: 1101: 1097: 1093: 1086: 1084: 1082: 1080: 1078: 1076: 1074: 1072: 1070: 1068: 1066: 1064: 1062: 1060: 1058: 1056: 1052: 1047: 1041: 1037: 1033: 1029: 1025: 1021: 1014: 1012: 1010: 1008: 1006: 1004: 1002: 1000: 998: 996: 994: 992: 990: 988: 986: 984: 982: 980: 978: 974: 969: 965: 960: 955: 950: 945: 941: 937: 933: 926: 923: 916: 912: 909: 907: 904: 902: 899: 898: 894: 892: 890: 886: 878: 876: 870: 868: 866: 861: 859: 855: 851: 847: 843: 841: 834: 832: 829: 825: 821: 817: 813: 809: 806:Avoidance of 801: 799: 797: 793: 789: 781: 779: 777: 773: 769: 765: 761: 757: 754: 750: 746: 742: 738: 734: 730: 722: 720: 717: 713: 705: 700: 697: 695: 692: 690: 687: 685: 682: 680: 677: 675: 674:streptokinase 672: 670: 667: 665: 662: 660: 657: 655: 652: 650: 647: 645: 642: 640: 637: 635: 632: 630: 627: 625: 622: 621: 619: 617: 606: 603: 595: 584: 581: 577: 574: 570: 567: 563: 560: 556: 553: â€“  552: 548: 547:Find sources: 541: 537: 533: 527: 526: 522: 517:This section 515: 511: 506: 505: 496: 493: 485: 475: 470: 468: 462: 458: 457: 450: 441: 440: 434: 432: 430: 426: 422: 418: 410: 408: 406: 402: 398: 394: 390: 386: 382: 378: 377:immune system 374: 370: 366: 358: 356: 354: 350: 346: 342: 338: 331:Complications 330: 328: 326: 322: 318: 314: 310: 306: 302: 294: 291: 288: 285:(swelling of 284: 281: 278: 275: 272: 268: 265: 262: 258: 255: 254: 253: 247: 245: 243: 239: 235: 231: 227: 223: 218: 216: 212: 208: 204: 200: 196: 192: 188: 184: 180: 176: 172: 168: 159: 157: 153: 150: 146: 142: 138: 135: 133: 129: 125: 121: 118: 114: 110: 106: 103: 99: 95: 92: 90: 86: 82: 78: 76: 72: 68: 65: 61: 57: 53: 49: 46: 44: 40: 37: 34: 32: 28: 23: 2374:Mantoux test 2303: 2035:Food allergy 1691: 1373: 1362: 1338: 1327: 1312: 1297: 1244:(4): 223–5. 1241: 1237: 1231: 1204: 1200: 1190: 1176: 1145: 1095: 1023: 939: 935: 925: 882: 874: 871:Epidemiology 862: 844: 838: 824:Skin testing 805: 785: 764:urine sample 729:blood sample 726: 709: 679:sulfonamides 664:procainamide 649:griseofulvin 629:barbiturates 613: 598: 589: 579: 572: 565: 558: 546: 530:Please help 518: 488: 479: 472:Please help 464: 453: 429:envenomation 414: 362: 334: 309:splenomegaly 298: 269:joint pain ( 251: 219: 209:). The term 166: 165: 69:, some drugs 2025:Anaphylaxis 2021:(Hay fever) 1715:Blood types 1614:Coombs test 1450:Whole blood 1364:MedlinePlus 889:BĂ©la Schick 768:proteinuria 654:penicillins 624:allopurinol 616:medications 476:if you can. 341:myocarditis 319:(decreased 317:hypotension 287:lymph nodes 2494:Autoimmune 2383:Autoimmune 2313:Autoimmune 2156:Autoimmune 2087:Autoimmune 1527:Blood bank 1340:DiseasesDB 917:References 858:Prednisone 854:analgesics 828:Physicians 808:antitoxins 802:Prevention 741:leukopenia 694:infliximab 562:newspapers 421:antitoxins 417:antibodies 397:vasculitis 371:. When an 311:(enlarged 271:arthralgia 242:prednisone 238:analgesics 226:urine test 222:blood test 215:penicillin 187:joint pain 149:prednisone 145:analgesics 132:Medication 108:Prevention 36:Hematology 2164:Cytotoxic 1732:Augustine 1676:reaction 1674:Hemolytic 1563:Apheresis 1455:Platelets 1375:eMedicine 891:in 1906. 840:Antiserum 835:Treatment 772:hematuria 737:platelets 723:Diagnosis 699:oxycodone 689:ibuprofen 684:rituximab 669:quinidine 659:phenytoin 634:captopril 592:June 2022 519:does not 425:infection 373:antiserum 175:antiserum 156:Prognosis 123:Treatment 67:antiserum 31:Specialty 2552:Category 2453:multiple 2451:Unknown/ 2253:Type III 2217:receptor 2066:Tree nut 1857:Lutheran 1762:Dombrock 1547:ISBT 128 1380:med/2105 1258:11231202 1223:17377915 1150:Saunders 968:16504095 895:See also 716:vaccines 712:hormones 482:May 2022 454:require 385:antigens 381:proteins 349:pleurisy 337:neuritis 207:type III 171:reaction 43:Symptoms 2460:Foreign 2362:Foreign 2353:T cells 2344:Type IV 2267:Foreign 2142:Foreign 2113:Type II 2056:Seafood 2002:Foreign 1984:allergy 1896:Scianna 1782:Gerbich 1685:delayed 1556:Methods 1334:D012713 1266:7001068 959:1397863 879:History 863:Use of 576:scholar 540:removed 525:sources 456:cleanup 293:malaise 261:redness 2481:(I+IV) 2213:Type V 2051:Peanut 1980:Type I 1807:Indian 1752:Cromer 1747:Colton 1472:Plasma 1369:000820 1264:  1256:  1221:  1164:  1114:  1042:  966:  956:  852:, and 794:, and 706:Others 644:crofab 578:  571:  564:  557:  549:  359:Causes 351:, and 313:spleen 257:rashes 224:and a 193:, and 179:animal 63:Causes 2320:Lupus 2071:Wheat 1988:atopy 1926:Other 1852:Lewis 1842:Knops 1822:KANNO 1767:Duffy 1757:Diego 1680:acute 1595:Tests 1345:11970 1323:999.5 1308:T80.6 1262:S2CID 1100:Mosby 942:: 3. 796:hives 788:lupus 743:(low 735:(low 583:JSTOR 569:books 435:Drugs 277:fever 191:fever 102:hives 94:lupus 52:fever 2521:APS2 2516:APS1 2430:GVHD 2117:ADCC 2046:Milk 1970:and 1906:T-Tn 1891:RHAG 1889:and 1882:Raph 1877:P1PK 1837:Kidd 1827:Kell 1792:GLOB 1777:FORS 1737:CD59 1482:PF24 1432:and 1329:MeSH 1318:9-CM 1254:PMID 1219:PMID 1162:ISBN 1112:ISBN 1040:ISBN 964:PMID 887:and 812:bite 778:). 762:. 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Index

Specialty
Hematology
Symptoms
rash
fever
lymphadenopathy
antiserum
Diagnostic method
complement protein
Differential diagnosis
lupus
erythema multiforme
hives
antihistamines
corticosteroids
Medication
corticosteroids
antihistamines
analgesics
prednisone
Prognosis
reaction
antiserum
animal
rash
joint pain
fever
lymphadenopathy
hypersensitivity
immune complex hypersensitivity

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