409:, to block the function of folic acid in patients with leukemia in hopes of achieving remission. In 1947, Farber conducted a clinical trial on aminopterin on 16 children, 10 of which eventually achieved temporary remission. While many practicing physicians responded to these results with enthusiasm, many scientists expressed disbelief and resistance against the new drug since Farber, a young pathologist at the time, was viewed as presumptuous. However, Farber's discovery marked a breakthrough in cancer research since no drugs had previously been found effective against tumors of the bodily fluids.
33:
453:, was originally offered for free by the Eli Lilly Pharmaceutical Company. Farber and his colleagues published their results on the efficacy of actinomycin D in 1960, and further development of treatment protocols by the National Wilms Tumor Study Group resulted in a 90% survival rate in children with Wilms' tumors by the end of the century.
514:
The success of the Jimmy Fund led Farber to realize the importance of marketing in the scientific advancement of knowledge about diseases. For the remainder of his career, Farber would extend far beyond his identity as a pathologist and oncologist, becoming not only a clinician but a public cancer
401:
was almost inevitably fatal and little was known about the mechanisms of the disease. Only basic forms of treatment were available, including red blood cell transfusions and antibiotics, leading to survival rates of merely weeks to months after diagnosis. Despite general pessimism in the scientific
335:
In 1946, Farber was named
Chairman of the Staff at the Children's Hospital, where he managed the Medical Center of Children's and envisioned an Institute for Pediatric Pathology which now exists as the Pediatric Research building. Farber was appointed Pathologist-in-Chief of the Children's Hospital
343:
gold-headed cane award. Throughout his career, Farber published more than 270 books and research papers on pediatric pathology, autopsy, and the history of medicine. Many remain classic references today, such as his 1937 book on autopsy methods and techniques titled
515:
research advocate too. This personal transition reflected the shift in society's attitude towards cancer as well; bringing cancer into the public spotlight propelled funding and awareness for cancer research for the remainder of the century and beyond.
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of New
England in 1947. Together they created the Children's Cancer Research Foundation (CCRF), which was one of the first nationwide fundraising efforts to take full advantage of modern media, such as a broadcast of the radio show
523:
Beginning in the early 1950s, and continuing until his death in 1973, Farber became a star presenter at
Congressional hearings on appropriations for cancer research. A compelling speaker, he was very successful in his efforts. With
428:
in this disease was achievable. These findings promoted Farber as the father of the modern era of chemotherapy for neoplastic disease, having already been recognized for a decade as a founder of modern pediatric pathology.
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Farber, S., Diamond, L.K., Mercer, R.D., Sylvester, R.F. & Wolff, J.A. (1948). "Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin)".
216:, which led to the development of other chemotherapeutic agents against other malignancies. Farber was also active in cancer research advocacy and fundraising, most notably through his establishment of the
402:
community towards efforts to cure cancer, Farber became dedicated to the battle against childhood leukemia in 1947 during his assistant professorship at
Children's Hospital and Harvard Medical School.
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Farber, S. (1952). "A lipid metabolic disorder: disseminated lipogranulomatosis; a syndrome with similarity to, and important difference from, Niemann-Pick and Hand-SchĂĽller-Christian disease".
324:
Following postgraduate training, Farber became an
Instructor in Pathology at Harvard Medical School in 1929. That same year, he was also appointed the first full-time pathologist to be based at
267:
256:
507:, rather than leukemia, Gustafson (nicknamed 'Jimmy' for publicity purposes) became an inspiration for all pediatric cancer patients and triggered the renaming of the CCRF to the
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In 1974, Farber's CCRF was renamed the Sidney Farber Cancer Center, and again in 1976 to the Sidney Farber Cancer
Institute. Long-term financial support by industrialist
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Farber discovered that folic acid plays a key role in the proliferation of cancer cells in leukemias. Realizing this, he attempted to use a folate antagonist,
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and his foundation was acknowledged by the building of the
Charles A. Dana Building in 1978 and the establishment of the Institute's present name of the
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of Rhode Island, Farber led the drive for a massive expansion in federal spending for cancer research. Between 1957 and 1967, the annual budget of the
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1260:
277:, prompting him to go to Europe. As Farber was fluent in German, he undertook his first year of medical school at the Universities of Heidelberg and
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In 1939, during his appointment at the
Children's Hospital, Farber worked with colleague Jerome S. Harris to publish a classic description of the
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Throughout the 1950s and '60s, Farber continued to make advances in cancer research, notably the 1955 discovery that the antibiotic
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Farber's research was primarily focused on diseases in children and infants. His work at
Children's spanned many areas, including
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499:. On May 22, 1948, one of the CCRF's first patients to respond to Farber's antifolate, a twelve-year-old boy named
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while working in his office. Upon his death he was survived by his widow, four children, and three grandchildren.
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332:. Farber was an extremely meticulous and precise scientist, and his laboratory become known for its tidiness.
270:, or SUNY Buffalo, in 1923. Farber Hall, built in 1953 on the South Campus of SUNY Buffalo, is named for him.
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Van Praagh, Richard (2012). "The Farber-Landing
Lecture: Pediatric Pathology—The Clinician's
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in the heart. This work played a major role in the development and advancement of pediatric
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While working at Harvard Medical School on a research project funded by a grant from the
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Miller, D.R. (2006). "A tribute to Sidney Farber – the father of modern chemotherapy".
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Cho, Kah Kyung; Rose, Lynn E. (1981). "Obituary: Marvin Farber (1901-1980)".
424:). He showed for the first time that induction of clinical and hematological
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251:). He was the third of 14 children. He was the younger brother of the noted
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220:, a foundation dedicated to pediatric research in childhood cancers. The
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and Its Importance in Pediatric Cardiology and Cardiovascular Surgery".
384:. As a result, Farber is now known as a founder of pediatric pathology.
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in 1947 and Professor of Pathology at Harvard Medical School in 1948.
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In the mid-1920s, Jewish students were often refused admission to US
74:
16:
American pediatric pathologist regarded as the father of chemotherapy
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449:, a pediatric cancer of the kidneys. The antibiotic, derived from
416:, he carried out both the preclinical and clinical evaluation of
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Recipients of the Lasker–DeBakey Clinical Medical Research Award
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241:
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Dana-Farber/Boston Children's Cancer and Blood Disorders Center
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On March 30, 1973, at the age of 69, Sidney Farber died from
528:, a longtime advocate of biomedical research, famed surgeon
328:, where he became a close mentee and friend of pathologist
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Chemotherapy, Fundraising and advocacy for cancer research
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488:
Farber began raising funds for cancer research with the
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Raffensperger, John (2015). "Max Wilms and his tumor".
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University at Buffalo, The State University of New York
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312:, and was appointed to a resident pathologist post at
201:(September 30, 1903 – March 30, 1973) was an American
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for his work using folic acid antagonists to combat
339:In 1973, Farber was presented with the prestigious
296:at Peter Bent Brigham Hospital (the predecessor of
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143:
107:
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85:
63:
42:
23:
794:The Emperor of All Maladies: A Biography of Cancer
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628:The Emperor of All Maladies: A Biography of Cancer
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289:as a second-year student and graduated in 1927.
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148:Lasker-DeBakey Clinical Medical Research Award
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1002:
900:"Curing Pediatric Acute Lymphocytic Leukemia"
285:. Having excelled in Germany, Farber entered
8:
991:: CS1 maint: multiple names: authors list (
587:of children's books, and classical soprano.
397:Through the mid- to late-1940s, childhood
31:
20:
1138:
208:. He is regarded as the father of modern
1049:American Journal of Diseases of Children
727:Philosophy and Phenomenological Research
463:transposition of the great blood vessels
292:Farber pursued postgraduate training in
640:
503:, appeared on the show. Despite having
1076:"History of the Dana-Farber Institute"
984:
393:Childhood acute lymphoblastic leukemia
1266:20th-century American philanthropists
1256:Philanthropists from New York (state)
865:Pediatric and Developmental Pathology
573:
245:
117:
7:
244:parents Simon Farber and Matilda (
14:
1241:Physicians from Buffalo, New York
1127:The American Journal of Pathology
1271:20th-century American physicians
1261:Scientists from New York (state)
683:10.1111/j.1365-2141.2006.06119.x
958:New England Journal of Medicine
366:infant hyaline membrane disease
133:
1123:"Sidney Farber, MD, 1903-1973"
1025:10.1016/j.jpedsurg.2014.10.054
904:American Society of Hematology
671:British Journal of Haematology
622:History of cancer chemotherapy
457:Other scientific contributions
352:Founder of pediatric pathology
1:
1221:Harvard Medical School alumni
388:Father of modern chemotherapy
1226:University at Buffalo alumni
1166:Dana–Farber Cancer Institute
1013:Journal of Pediatric Surgery
934:Dana–Farber Cancer Institute
558:Dana–Farber Cancer Institute
548:Dana–Farber Cancer Institute
476:that was subsequently named
472:In 1952, Farber described a
399:acute lymphoblastic leukemia
382:sudden infant death syndrome
298:Brigham and Women's Hospital
222:Dana–Farber Cancer Institute
187:Dana–Farber Cancer Institute
1281:ASIP gold-headed cane award
1196:American cancer researchers
1121:Bailey, Orville T. (1974).
971:10.1056/nejm194806032382301
536:of Alabama and Congressman
445:could produce remission in
370:Eastern equine encephalitis
308:, where he was mentored by
1297:
1276:20th-century American Jews
1216:Jewish American scientists
1171:Boston Children's Hospital
830:(6): 43–44. June 1, 1972.
820:"News: AAPB honors Farber"
346:The Postmortem Examination
183:Boston Children's Hospital
542:National Cancer Institute
192:
153:
30:
519:Cancer research advocacy
1181:American Cancer Society
877:10.2350/10-10-0924-OA.1
759:. New York Public Radio
414:American Cancer Society
1206:American pediatricians
798:. Simon and Schuster.
374:eosinophilic granuloma
287:Harvard Medical School
266:Farber graduated from
1201:American pathologists
836:10.1093/labmed/3.6.43
496:Truth or Consequences
474:lipid storage disease
451:Streptomyces parvulus
422:Yellapragada Subbarow
257:University of Buffalo
90:University at Buffalo
432:
224:is named after him.
930:"Sidney Farber, MD"
824:Laboratory Medicine
526:Mary Woodard Lasker
441:and post-operative
330:Simeon Burt Wolbach
326:Children's Hospital
314:Children's Hospital
530:Michael E. DeBakey
94:Harvard University
53:September 30, 1903
1211:Jewish physicians
1101:Poetry Foundation
805:978-1-4391-0795-9
617:History of cancer
443:radiation therapy
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155:Scientific career
57:Buffalo, New York
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420:(synthesized by
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753:"Sidney Farber"
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607:(2015 PBS film)
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501:Einar Gustafson
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467:cardiac surgery
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275:medical schools
249: Goldstein
232:He was born in
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1160:External links
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1133:(2): 129–133.
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1097:"Norma Farber"
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1056:(4): 499–500.
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579:) in 1928, a
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263:(1901–1980).
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261:Marvin Farber
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25:Sidney Farber
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19:
1246:Chemotherapy
1130:
1126:
1116:
1106:September 6,
1104:. Retrieved
1100:
1091:
1081:September 6,
1079:. Retrieved
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1041:
1016:
1012:
987:cite journal
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939:September 6,
937:. Retrieved
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909:September 6,
907:. Retrieved
903:
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841:February 24,
839:. Retrieved
827:
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761:. Retrieved
756:
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730:
726:
677:(1): 20–26.
674:
670:
626:
604:
589:
570:Norma Farber
567:
551:
522:
513:
494:
490:Variety Club
487:
471:
460:
450:
447:Wilms' tumor
436:
433:Wilms' tumor
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210:chemotherapy
198:
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179:Institutions
154:
69:(1973-03-30)
18:
1236:1973 deaths
1231:1903 births
861:Open Sesame
418:aminopterin
407:aminopterin
253:philosopher
206:pathologist
1190:Categories
733:(1): 1–4.
635:References
532:, Senator
509:Jimmy Fund
259:professor
228:Early life
218:Jimmy Fund
173:pediatrics
49:1903-09-30
763:April 20,
560:in 1983.
426:remission
316:in 1929.
294:pathology
203:pediatric
169:pathology
1062:12975849
1033:25638637
979:18860765
885:22877152
790:(2010).
699:45434777
691:16803563
598:See also
279:Freiburg
238:New York
214:leukemia
165:oncology
1149:4614669
1140:1910912
739:2107539
283:Germany
234:Buffalo
138:
130:
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1147:
1137:
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1031:
977:
883:
802:
737:
697:
689:
605:Cancer
585:author
380:, and
320:Career
302:Boston
242:Jewish
161:Fields
144:Awards
108:Spouse
75:Boston
735:JSTOR
695:S2CID
300:) in
240:, to
132:(
128:
114:Norma
1145:PMID
1108:2019
1083:2019
1058:PMID
1029:PMID
993:link
975:PMID
941:2019
911:2019
881:PMID
843:2024
800:ISBN
765:2018
757:WNYC
687:PMID
581:poet
341:ASIP
255:and
64:Died
43:Born
1135:PMC
1021:doi
967:doi
963:238
873:doi
832:doi
679:doi
675:134
575:née
281:in
247:née
119:née
1192::
1143:.
1131:77
1129:.
1125:.
1099:.
1054:84
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1027:.
1017:50
1015:.
1001:^
989:}}
985:{{
973:.
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919:^
902:.
879:.
869:15
867:.
851:^
826:.
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773:^
755:.
731:42
729:.
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