304:
281:
178:
203:
3029:
555:
310:
209:
31:
4339:
4356:
1387:, another member of the Tec kinase family. Deletion of Btk results in a compensatory increased expression of Tec kinase, but a change in B-cell phenotype is observed, indicating Btk has a more important role in B-cell development than Tec. When both Btk and Tec are deleted, a severe B-cell deficiency is observed.
1234:. Type IV isoform has a full length SH3 domain and is predominately expressed in hematopoietic cells. Type III isoform has a SH3 domain that lacks the COOH-terminal 22 residues and is predominately expressed in the liver and kidney. It is likely the shortened SH3 domain of type III Tec kinase is a disabled form.
1535:
is costly. Inhibition of Tec family kinases may provide an alternative treatment for RA. Btk is the main target of inhibition, but because of the compensatory role of Tec kinase to Btk, an inhibition involving both Btk and Tec kinase may be needed. Blocking Tec family kinases could reduce the
57:
1204:(PH) domain on the N-terminus of the molecule followed by a Tec homology (TH) domain. The TH domain of Tec kinase contains a Btk homology (BH) motif and two proline-rich (PR) regions. The other protein interaction domains of Tec kinase include
1594:
and proinflammatory cytokines from granulocytes. Dasatinib has also been found to inhibit T-cell effector functions through Tec family kinase inhibition, suggesting this drug could be used to suppress immune response for
2749:
Laffargue M, Monnereau L, Tuech J, Ragab A, Ragab-Thomas J, Payrastre B, et al. (September 1997). "Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets".
1324:
stimulation. Tec kinase plays an important role in T-cell activation. Upon TCR/CD28 stimulation, Tec kinase is recruited to the cytoplasmic tail of CD28 and takes part in a signaling pathway that leads to activation of
1453:
patients. Patients deficient in both Btk and Tec kinase display greatly impaired phosphorylation of PLCγ2, no aggregation of platelets in response to high doses of collagen, and greatly impaired spreading of collagen.
1617:
Tec kinase was first discovered in 1990 while researchers investigated mouse liver for novel protein-tyrosine kinase isolation. Expression of Tec kinase was initially found in mouse liver, kidney, spleen, and heart.
1347:
effector/memory cells is observed during a primary immune response, indicating Tec kinase may help in controlling Th17 subsets. Additionally, Th17 cells in the absence of Tec kinase produced higher levels of
2656:
Ohta Y, Haire RN, Amemiya CT, Litman RT, Träger T, Riess O, Litman GW (February 1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene".
1343:
cell functions. In Th2 cells, Tec kinase is upregulated, indicating it may perform an important function in the regulation of Th2 cells. In the absence of Tec kinase, an increase in
1596:
2576:
Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, et al. (February 1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases".
2712:
Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK".
2254:
Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK".
317:
216:
3484:
3028:
3908:
3069:
1486:
883:
2512:
Machide M, Mano H, Todokoro K (August 1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain".
864:
139:
3781:
1765:
Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (October 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase".
3207:
1462:
2448:
Mano H, Ishikawa F, Nishida J, Hirai H, Takaku F (December 1990). "A novel protein-tyrosine kinase, tec, is preferentially expressed in liver".
4430:
3522:
1336:
promoters. It is likely Tec kinase plays a regulatory role in this signaling pathway in activated T cells, but its full function is not known.
4401:
3164:
3008:
1747:
1481:
Tec kinase is activated through a similar process to other members of the Tec kinase family. Tec kinase must first be relocated to the
2215:"Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling"
1729:
4420:
3192:
2867:
2850:
3560:
3551:
3251:
3246:
3241:
3236:
303:
3445:
3436:
1665:
1107:
4058:
3227:
1361:
1114:
280:
3130:
1792:
1426:
signaling proteins. Tec kinase is likely involved in the same manner in macrophages, as it has a compensatory function for Btk.
1716:
1695:
1545:
1449:
collagen receptor. Btk plays a more important role in these processes, but Tec kinase is able to compensate for loss of Btk in
3062:
4214:
1712:
1883:
Boucheron N, Ellmeier W (April 2012). "The role of Tec family kinases in the regulation of T-helper-cell differentiation".
202:
177:
54:
3275:
2117:"Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells"
4329:
2026:
1691:
3706:
3638:
3629:
1571:
1189:
119:
4012:
4003:
3939:
3767:
1627:
1450:
3983:
1384:
3450:
1201:
316:
215:
4199:
2471:"Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding"
2166:"Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding"
4425:
4394:
4315:
4302:
4289:
4276:
4263:
4250:
4237:
3055:
3001:
1493:
4209:
1254:, another member of the Tec kinase family, making it likely these two kinase genes arose through the process of
309:
208:
4163:
4106:
3100:
3086:
1606:
1280:
928:
127:
1465:. It is not clear what the function of Tec kinase is in neutrophils. Tec kinase is also expressed in primary
4111:
3824:
3815:
1941:
Mano H (1999-09-01). "Tec family of protein-tyrosine kinases: an overview of their structure and function".
1364:. This indicates Tec kinase could be used as a target to enhance Th17 cell function during reinfection with
1357:
1200:
Tec kinase contains five protein interaction domains. The characteristic feature of Tec family kinases is a
1181:
909:
2116:
1823:
Schmidt U, Boucheron N, Unger B, Ellmeier W (May 2004). "The role of Tec family kinases in myeloid cells".
3113:
1528:
1330:
4132:
4051:
3776:
3460:
2679:"Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways"
1407:
1404:
4204:
1540:
from B cells, limit the secretion of proinflammatory cytokines from macrophages, and inhibit mast cell
1512:
of a tyrosine residue in the Tec kinase SH3 domain, which allows the Tec kinase to be fully activated.
2677:
Cory GO, MacCarthy-Morrogh L, Banin S, Gout I, Brickell PM, Levinsky RJ, et al. (November 1996).
2384:
Mano H (2000). "Tec family of protein-tyrosine kinases: an overview of their structure and function".
1590:
is a tyrosine kinase inhibitor that has been found to bind to Tec kinase and Btk, limiting release of
4387:
2994:
2897:
2585:
2066:
1520:
1321:
1231:
191:
106:
4168:
3474:
1509:
1205:
1086:
1082:
1078:
1027:
1023:
1019:
1383:
changes detected in Tec-deficient mice. This is likely because Tec has overlapping functions with
4101:
3858:
3848:
3839:
3667:
3658:
2737:
2609:
2564:
2279:
2115:
van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von
Lindern M (November 2000).
2008:
1983:
Horwood NJ, Urbaniak AM, Danks L (April 2012). "Tec family kinases in inflammation and disease".
1908:
1848:
1524:
1396:
151:
3047:
2886:"Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase"
2884:
Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, et al. (October 1999).
1090:
1057:
1031:
998:
3892:
2966:
2945:
2925:
2872:
2837:
2802:
2767:
2729:
2700:
2665:
2644:
2601:
2556:
2521:
2500:
2457:
2436:
2401:
2361:
2320:
2271:
2236:
2195:
2146:
2094:
2000:
1958:
1900:
1840:
1774:
1549:
1505:
1272:
99:
47:
4371:
2299:"Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription"
4147:
4142:
4116:
4044:
3169:
3155:
2915:
2905:
2862:
2827:
2792:
2759:
2721:
2690:
2634:
2593:
2546:
2490:
2482:
2426:
2393:
2351:
2338:
Ohya K, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, et al. (October 1997).
2310:
2263:
2226:
2185:
2177:
2136:
2128:
2084:
2074:
1992:
1950:
1892:
1832:
1579:
1344:
1313:
1255:
396:
327:
271:
226:
3416:
2851:"Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway"
2297:
Yamashita Y, Watanabe S, Miyazato A, Ohya K, Ikeda U, Shimada K, et al. (March 1998).
2055:"Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF"
4194:
4178:
4091:
3757:
3426:
3411:
3401:
3396:
3376:
3371:
3366:
3361:
3356:
3347:
3082:
1501:
1376:
1317:
1227:
1170:
371:
147:
2901:
2589:
2070:
554:
4343:
4232:
4173:
3887:
3882:
3877:
3261:
3078:
1659:
1470:
1353:
2639:
2623:"Regulation of Btk function by a major autophosphorylation site within the SH3 domain"
2622:
2495:
2470:
2431:
2414:
2397:
2190:
2165:
2089:
2054:
1954:
1188:
processes. Tec kinase is the name-giving member of the Tec kinase family, a family of
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
692:
687:
682:
677:
672:
667:
651:
646:
641:
636:
631:
626:
621:
616:
611:
606:
601:
596:
4414:
4137:
4096:
3323:
3184:
2975:
2954:
2920:
2885:
2012:
1544:. There are no known inhibitors of Tec kinase at the present. However, Tec kinase is
1541:
1532:
1482:
1411:
1340:
1326:
1309:
1185:
583:
2613:
2568:
2535:"Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase"
1852:
1414:. Btk has an important function in this pathway, as it has been observed to bind to
30:
4367:
4086:
3868:
3579:
3570:
3314:
2781:"Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells"
2741:
2283:
1912:
1537:
1301:
389:
168:
131:
2597:
1996:
1896:
1287:
molecules. They are also key players in the regulation of the immune functions.
155:
4310:
4245:
4081:
2695:
2678:
2621:
Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, Tam C, et al. (May 1996).
2551:
2534:
1752:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1734:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1583:
1557:
4338:
2890:
Proceedings of the
National Academy of Sciences of the United States of America
2059:
Proceedings of the
National Academy of Sciences of the United States of America
472:
3993:
3988:
3978:
3913:
3829:
3719:
2868:
10.1002/(SICI)1521-4141(199906)29:06<1842::AID-IMMU1842>3.0.CO;2-D
2132:
2027:"TEC tec protein tyrosine kinase [Homo sapiens (human)] - Gene - NCBI"
1458:
1400:
1250:
1241:
1213:
1209:
288:
185:
135:
2910:
2356:
2339:
2315:
2298:
1271:
Tec family kinases are involved in the intracellular signaling mechanisms of
4284:
4258:
2797:
2780:
2079:
1591:
1587:
1527:
that results in swollen, painful joints. Standard treatment for RA involves
1466:
1380:
828:
532:
410:
355:
342:
254:
241:
143:
2929:
2876:
2763:
2725:
2486:
2440:
2405:
2267:
2240:
2231:
2214:
2181:
2150:
2098:
2004:
1962:
1904:
1844:
2841:
2832:
2815:
2806:
2771:
2733:
2704:
2669:
2648:
2605:
2560:
2525:
2504:
2461:
2365:
2324:
2275:
2199:
1778:
1485:, which is mediated by the interaction of its PH domain with phospholipid
1154:
1149:
3728:
3135:
1635:
1497:
1438:
1434:
1430:
1365:
1333:
1284:
1138:
973:
954:
1586:
proliferate. Tyrosine kinase inhibitors are largely used for treatment.
2980:
2970:
2959:
2949:
2340:"SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase"
1442:
1276:
940:
895:
3037:: NMR STRUCTURE OF THE SH3 DOMAIN FROM THE TEC PROTEIN TYROSINE KINASE
1836:
76:
4297:
4067:
4017:
3280:
3216:
3211:
2141:
1575:
1561:
1372:
1305:
1217:
1122:
850:
4355:
2213:
Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (April 2002).
4271:
3805:
3683:
3648:
3643:
3619:
3421:
3406:
3391:
3386:
3381:
3333:
3328:
3304:
3299:
3290:
3202:
3197:
3174:
3145:
3140:
1653:
1641:
1565:
1423:
1419:
1349:
813:
809:
4363:
3923:
3853:
3800:
3791:
3752:
3743:
3733:
3614:
3605:
3595:
3541:
3532:
3517:
3508:
3498:
3493:
3469:
3270:
3122:
2533:
Mano H, Yamashita Y, Miyazato A, Miura Y, Ozawa K (April 1996).
1647:
1446:
1415:
1177:
734:
transmembrane receptor protein tyrosine kinase signaling pathway
123:
4040:
3704:
3098:
3051:
2990:
563:
3954:
3949:
3944:
3918:
2986:
2816:"The role of Tec protein-tyrosine kinase in T cell signaling"
2965:
Overview of all the structural information available in the
2944:
Overview of all the structural information available in the
1473:
cells. Its function has not been identified in these cells.
4036:
2779:
Kitanaka A, Mano H, Conley ME, Campana D (February 1998).
683:
extrinsic component of cytoplasmic side of plasma membrane
1184:, liver, and kidney cells and plays an important role in
2814:
Yang WC, Ghiotto M, Barbarat B, Olive D (January 1999).
759:
positive regulation of peptidyl-tyrosine phosphorylation
379:
4375:
2415:"Tec kinases: a family with multiple roles in immunity"
2053:
Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003).
1500:
residue within the kinase domain of Tec kinase is then
612:
non-membrane spanning protein tyrosine kinase activity
4327:
2413:
Yang WC, Collette Y, Nunès JA, Olive D (April 2000).
1308:
activation, especially in the presence of TGF-ß1 and
544:
1312:. Tec kinase is activated in T cells in response to
4223:
4187:
4156:
4125:
4074:
4002:
3963:
3932:
3901:
3867:
3838:
3814:
3790:
3766:
3742:
3718:
3676:
3657:
3628:
3604:
3588:
3569:
3550:
3531:
3507:
3483:
3459:
3435:
3346:
3313:
3289:
3260:
3226:
3183:
3154:
3121:
3112:
2752:
1071:
1050:
1012:
991:
1708:
1706:
1704:
1687:
1685:
1683:
1461:upon neutrophil stimulation with chemoattractant
326:
225:
1825:International Archives of Allergy and Immunology
1445:activation, platelet aggregation, and spreading
2469:Tang B, Mano H, Yi T, Ihle JN (December 1994).
2164:Tang B, Mano H, Yi T, Ihle JN (December 1994).
2110:
2108:
2048:
2046:
1793:"Entrez Gene: TEC tec protein tyrosine kinase"
1713:GRCm38: Ensembl release 89: ENSMUSG00000029217
1441:. Tec kinase is involved in the regulation of
4395:
4052:
3063:
3002:
8:
2979:(Mouse Tyrosine-protein kinase Tec) at the
2958:(Human Tyrosine-protein kinase Tec) at the
1692:GRCh38: Ensembl release 89: ENSG00000135605
1564:and by SH2-containing tyrosine phosphatase
754:regulation of cell population proliferation
4402:
4388:
4059:
4045:
4037:
3715:
3701:
3118:
3109:
3095:
3070:
3056:
3048:
3009:
2995:
2987:
1379:stimulation. However, there are no B-cell
824:
579:
367:
266:
163:
65:
2919:
2909:
2866:
2831:
2796:
2694:
2638:
2550:
2494:
2430:
2355:
2314:
2230:
2189:
2140:
2088:
2078:
4334:
3024:
1679:
1230:that differ in the SH3 domain through
20:
1978:
1976:
1974:
1972:
1190:non-receptor protein-tyrosine kinases
764:peptidyl-tyrosine autophosphorylation
744:Fc-epsilon receptor signaling pathway
331:
292:
287:
230:
189:
184:
110:, PSCTK4, tec protein tyrosine kinase
7:
4352:
4350:
2386:Cytokine & Growth Factor Reviews
1943:Cytokine & Growth Factor Reviews
1936:
1934:
1932:
1930:
1928:
1926:
1924:
1922:
1878:
1876:
1874:
1872:
1870:
1868:
1866:
1864:
1862:
1818:
1816:
1814:
1812:
1810:
1808:
1806:
1804:
1802:
2820:The Journal of Biological Chemistry
2344:The Journal of Biological Chemistry
2219:The Journal of Biological Chemistry
1985:International Reviews of Immunology
1885:International Reviews of Immunology
794:cytokine-mediated signaling pathway
769:integrin-mediated signaling pathway
4374:. You can help Knowledge (XXG) by
1666:Suppressor of cytokine signaling 1
1068:
1047:
1009:
988:
964:
945:
919:
900:
874:
855:
549:
467:
405:
384:
14:
1605:gene may also be associated with
1300:Tec kinase has low expression in
1173:that in humans is encoded by the
799:T cell receptor signaling pathway
779:regulation of platelet activation
774:peptidyl-tyrosine phosphorylation
719:intracellular signal transduction
709:B cell receptor signaling pathway
4354:
4337:
3027:
1599:and T-cell autoimmune diseases.
1248:is located only 1.5kb away from
1220:domain with enzymatic activity.
632:protein tyrosine kinase activity
553:
315:
308:
302:
279:
214:
207:
201:
176:
29:
1433:upon platelet stimulation with
1395:Tec kinase plays a role in the
1339:Tec kinase also contributes to
1267:Functions of Tec family kinases
2855:European Journal of Immunology
2849:Yang WC, Olive D (June 1999).
2475:Molecular and Cellular Biology
2170:Molecular and Cellular Biology
564:More reference expression data
533:More reference expression data
1:
4431:Human chromosome 4 gene stubs
3707:Non-receptor tyrosine kinases
2640:10.1016/S1074-7613(00)80417-3
2432:10.1016/S1074-7613(00)80189-2
2398:10.1016/S1359-6101(99)00019-2
1955:10.1016/S1359-6101(99)00019-2
1626:TEC (gene) has been shown to
1180:. Tec kinase is expressed in
300:
199:
2598:10.1126/science.271.5250.822
1997:10.3109/08830185.2012.670334
1897:10.3109/08830185.2012.664798
4421:Genes on human chromosome 4
2696:10.4049/jimmunol.157.9.3791
2552:10.1096/fasebj.10.5.8621063
1457:Tec kinase is activated in
1429:Tec kinase is activated in
1399:(TLR) signaling pathway of
1371:Tec kinase is expressed in
1167:Tyrosine-protein kinase Tec
4447:
4349:
1405:pro-inflammatory cytokines
637:signaling receptor binding
4215:Michaelis–Menten kinetics
3714:
3700:
3108:
3101:Receptor tyrosine kinases
3094:
3022:
2133:10.1182/blood.V96.10.3406
1748:"Mouse PubMed Reference:"
1730:"Human PubMed Reference:"
1244:4, locus 4p12 in humans.
1153:
1148:
1144:
1137:
1121:
1102:
1075:
1054:
1043:
1016:
995:
984:
971:
967:
952:
948:
939:
926:
922:
907:
903:
894:
881:
877:
862:
858:
849:
834:
827:
823:
807:
582:
578:
561:
552:
543:
530:
479:
470:
417:
408:
378:
370:
366:
349:
336:
299:
278:
269:
265:
248:
235:
198:
175:
166:
162:
117:
114:
104:
97:
92:
73:
68:
51:
46:
41:
37:
28:
23:
4107:Diffusion-limited enzyme
2911:10.1073/pnas.96.21.11976
2357:10.1074/jbc.272.43.27178
2316:10.1182/blood.V91.5.1496
1607:myelodysplastic syndrome
1572:Chronic myeloid leukemia
1531:and receptors, but this
1304:but is upregulated upon
1283:-coupled receptors, and
1281:heterotrimeric G-protein
724:adaptive immune response
3114:Growth factor receptors
2798:10.1182/blood.V91.3.940
2080:10.1073/pnas.0234057100
1291:Functions of Tec kinase
1115:Chr 5: 72.91 – 73.03 Mb
1108:Chr 4: 48.14 – 48.27 Mb
749:protein phosphorylation
607:protein kinase activity
2764:10.1006/bbrc.1997.7269
2726:10.1038/sj.onc.1201071
2487:10.1128/MCB.14.12.8432
2268:10.1038/sj.onc.1201071
2232:10.1074/jbc.M200277200
2182:10.1128/MCB.14.12.8432
1529:recombinant antibodies
1375:and is activated upon
784:innate immune response
499:mesenteric lymph nodes
333:5 C3.2|5 38.44 cM
4200:Eadie–Hofstee diagram
4133:Allosteric regulation
2833:10.1074/jbc.274.2.607
2683:Journal of Immunology
1516:Clinical Significance
1275:, lymphocyte surface
739:immune system process
4210:Lineweaver–Burk plot
3185:PDGF receptor family
2031:www.ncbi.nlm.nih.gov
1521:Rheumatoid arthritis
1451:XLA immune-deficient
1232:alternative splicing
714:cell differentiation
642:phospholipid binding
597:transferase activity
457:right adrenal cortex
294:Chromosome 5 (mouse)
192:Chromosome 4 (human)
69:List of PDB id codes
42:Available structures
3589:ROS receptor family
3123:EGF receptor family
2902:1999PNAS...9611976O
2590:1996Sci...271..822R
2071:2003PNAS..100..733S
1525:autoimmune disorder
1510:autophosphorylation
1202:pleckstrin homology
789:tissue regeneration
4362:This article on a
4169:Enzyme superfamily
4102:Enzyme promiscuity
1533:biological therapy
1508:. This allows for
1506:Src family kinases
1397:toll-like receptor
1273:cytokine receptors
929:ENSMUSG00000029217
702:Biological process
661:Cellular component
602:nucleotide binding
590:Molecular function
495:left lobe of liver
445:right uterine tube
4383:
4382:
4325:
4324:
4034:
4033:
4030:
4029:
4026:
4025:
3696:
3695:
3692:
3691:
3342:
3341:
3045:
3044:
1837:10.1159/000078339
1580:white blood cells
1550:dephosphorylation
1164:
1163:
1160:
1159:
1133:
1132:
1098:
1097:
1065:
1064:
1039:
1038:
1006:
1005:
980:
979:
961:
960:
935:
934:
916:
915:
890:
889:
871:
870:
819:
818:
617:metal ion binding
574:
573:
570:
569:
539:
538:
526:
525:
464:
463:
425:bone marrow cells
362:
361:
261:
260:
88:
87:
84:
83:
52:Ortholog search:
4438:
4426:Tyrosine kinases
4404:
4397:
4390:
4358:
4351:
4342:
4341:
4333:
4205:Hanes–Woolf plot
4148:Enzyme activator
4143:Enzyme inhibitor
4117:Enzyme catalysis
4061:
4054:
4047:
4038:
3716:
3702:
3156:Insulin receptor
3119:
3110:
3096:
3083:tyrosine kinases
3072:
3065:
3058:
3049:
3031:
3011:
3004:
2997:
2988:
2933:
2923:
2913:
2896:(21): 11976–81.
2880:
2870:
2845:
2835:
2810:
2800:
2775:
2745:
2708:
2698:
2673:
2652:
2642:
2617:
2572:
2554:
2529:
2508:
2498:
2465:
2444:
2434:
2409:
2370:
2369:
2359:
2350:(43): 27178–82.
2335:
2329:
2328:
2318:
2294:
2288:
2287:
2251:
2245:
2244:
2234:
2210:
2204:
2203:
2193:
2161:
2155:
2154:
2144:
2112:
2103:
2102:
2092:
2082:
2050:
2041:
2040:
2038:
2037:
2023:
2017:
2016:
1980:
1967:
1966:
1949:(3–4): 267–280.
1938:
1917:
1916:
1880:
1857:
1856:
1820:
1797:
1796:
1789:
1783:
1782:
1762:
1756:
1755:
1744:
1738:
1737:
1726:
1720:
1710:
1699:
1689:
1256:gene-duplication
1228:protein isoforms
1146:
1145:
1117:
1110:
1093:
1069:
1060:
1048:
1044:RefSeq (protein)
1034:
1010:
1001:
989:
965:
946:
920:
901:
875:
856:
825:
580:
566:
557:
550:
535:
475:
473:Top expressed in
468:
413:
411:Top expressed in
406:
385:
368:
358:
345:
334:
319:
312:
306:
295:
283:
267:
257:
244:
233:
218:
211:
205:
194:
180:
164:
158:
109:
102:
79:
66:
60:
39:
38:
33:
21:
4446:
4445:
4441:
4440:
4439:
4437:
4436:
4435:
4411:
4410:
4409:
4408:
4348:
4336:
4328:
4326:
4321:
4233:Oxidoreductases
4219:
4195:Enzyme kinetics
4183:
4179:List of enzymes
4152:
4121:
4092:Catalytic triad
4070:
4065:
4035:
4022:
3998:
3959:
3928:
3897:
3863:
3834:
3810:
3786:
3762:
3738:
3710:
3688:
3672:
3653:
3624:
3600:
3584:
3565:
3546:
3527:
3503:
3479:
3455:
3431:
3338:
3309:
3285:
3256:
3222:
3179:
3150:
3104:
3090:
3079:Protein kinases
3076:
3046:
3041:
3038:
3032:
3018:
3015:
2941:
2936:
2883:
2848:
2813:
2778:
2748:
2720:(19): 2273–82.
2711:
2676:
2655:
2620:
2584:(5250): 822–5.
2575:
2532:
2511:
2468:
2447:
2412:
2392:(3–4): 267–80.
2383:
2379:
2377:Further reading
2374:
2373:
2337:
2336:
2332:
2309:(5): 1496–507.
2296:
2295:
2291:
2262:(19): 2273–82.
2253:
2252:
2248:
2225:(16): 13732–8.
2212:
2211:
2207:
2163:
2162:
2158:
2127:(10): 3406–13.
2114:
2113:
2106:
2052:
2051:
2044:
2035:
2033:
2025:
2024:
2020:
1982:
1981:
1970:
1940:
1939:
1920:
1882:
1881:
1860:
1822:
1821:
1800:
1791:
1790:
1786:
1773:(10): 1663–72.
1764:
1763:
1759:
1746:
1745:
1741:
1728:
1727:
1723:
1711:
1702:
1690:
1681:
1676:
1671:
1624:
1615:
1597:transplantation
1555:
1518:
1492:generated from
1490:
1483:plasma membrane
1479:
1393:
1377:B-cell receptor
1316:engagement and
1298:
1293:
1269:
1264:
1198:
1171:tyrosine kinase
1155:View/Edit Mouse
1150:View/Edit Human
1113:
1106:
1103:Location (UCSC)
1089:
1085:
1081:
1077:
1056:
1030:
1026:
1022:
1018:
997:
910:ENSG00000135605
803:
729:phosphorylation
697:
693:plasma membrane
656:
627:protein binding
622:kinase activity
562:
531:
522:
517:
513:
509:
507:proximal tubule
505:
501:
497:
493:
489:
485:
471:
460:
455:
451:
447:
443:
439:
437:skin of abdomen
435:
431:
427:
423:
409:
353:
340:
332:
322:
321:
320:
313:
293:
270:Gene location (
252:
239:
231:
221:
220:
219:
212:
190:
167:Gene location (
156:TEC - orthologs
118:
105:
98:
75:
53:
19:
12:
11:
5:
4444:
4442:
4434:
4433:
4428:
4423:
4413:
4412:
4407:
4406:
4399:
4392:
4384:
4381:
4380:
4359:
4347:
4346:
4323:
4322:
4320:
4319:
4306:
4293:
4280:
4267:
4254:
4241:
4227:
4225:
4221:
4220:
4218:
4217:
4212:
4207:
4202:
4197:
4191:
4189:
4185:
4184:
4182:
4181:
4176:
4171:
4166:
4160:
4158:
4157:Classification
4154:
4153:
4151:
4150:
4145:
4140:
4135:
4129:
4127:
4123:
4122:
4120:
4119:
4114:
4109:
4104:
4099:
4094:
4089:
4084:
4078:
4076:
4072:
4071:
4066:
4064:
4063:
4056:
4049:
4041:
4032:
4031:
4028:
4027:
4024:
4023:
4021:
4020:
4015:
4009:
4007:
4000:
3999:
3997:
3996:
3991:
3986:
3981:
3976:
3970:
3968:
3961:
3960:
3958:
3957:
3952:
3947:
3942:
3936:
3934:
3930:
3929:
3927:
3926:
3921:
3916:
3911:
3905:
3903:
3899:
3898:
3896:
3895:
3890:
3885:
3880:
3874:
3872:
3865:
3864:
3862:
3861:
3856:
3851:
3845:
3843:
3836:
3835:
3833:
3832:
3827:
3821:
3819:
3812:
3811:
3809:
3808:
3803:
3797:
3795:
3788:
3787:
3785:
3784:
3779:
3773:
3771:
3764:
3763:
3761:
3760:
3755:
3749:
3747:
3740:
3739:
3737:
3736:
3731:
3725:
3723:
3712:
3711:
3705:
3698:
3697:
3694:
3693:
3690:
3689:
3687:
3686:
3680:
3678:
3674:
3673:
3671:
3670:
3664:
3662:
3655:
3654:
3652:
3651:
3646:
3641:
3635:
3633:
3626:
3625:
3623:
3622:
3617:
3611:
3609:
3606:AATYK receptor
3602:
3601:
3599:
3598:
3592:
3590:
3586:
3585:
3583:
3582:
3576:
3574:
3567:
3566:
3564:
3563:
3557:
3555:
3548:
3547:
3545:
3544:
3538:
3536:
3529:
3528:
3526:
3525:
3520:
3514:
3512:
3505:
3504:
3502:
3501:
3496:
3490:
3488:
3481:
3480:
3478:
3477:
3472:
3466:
3464:
3457:
3456:
3454:
3453:
3448:
3442:
3440:
3433:
3432:
3430:
3429:
3424:
3419:
3414:
3409:
3404:
3399:
3394:
3389:
3384:
3379:
3374:
3369:
3364:
3359:
3353:
3351:
3344:
3343:
3340:
3339:
3337:
3336:
3331:
3326:
3320:
3318:
3311:
3310:
3308:
3307:
3302:
3296:
3294:
3287:
3286:
3284:
3283:
3278:
3273:
3267:
3265:
3262:VEGF receptors
3258:
3257:
3255:
3254:
3249:
3244:
3239:
3233:
3231:
3224:
3223:
3221:
3220:
3214:
3205:
3200:
3195:
3189:
3187:
3181:
3180:
3178:
3177:
3172:
3167:
3161:
3159:
3152:
3151:
3149:
3148:
3143:
3138:
3133:
3127:
3125:
3116:
3106:
3105:
3099:
3092:
3091:
3077:
3075:
3074:
3067:
3060:
3052:
3043:
3042:
3040:
3039:
3033:
3026:
3023:
3020:
3019:
3016:
3014:
3013:
3006:
2999:
2991:
2985:
2984:
2963:
2940:
2939:External links
2937:
2935:
2934:
2881:
2846:
2811:
2776:
2746:
2709:
2674:
2653:
2618:
2573:
2530:
2509:
2481:(12): 8432–7.
2466:
2456:(12): 1781–6.
2445:
2410:
2380:
2378:
2375:
2372:
2371:
2330:
2289:
2246:
2205:
2176:(12): 8432–7.
2156:
2104:
2042:
2018:
1968:
1918:
1858:
1798:
1784:
1757:
1739:
1721:
1700:
1678:
1677:
1675:
1672:
1670:
1669:
1663:
1660:Janus kinase 2
1657:
1651:
1645:
1639:
1632:
1623:
1620:
1614:
1611:
1553:
1538:autoantibodies
1536:production of
1517:
1514:
1502:phosphorylated
1488:
1478:
1475:
1403:that produces
1392:
1389:
1297:
1296:Lymphoid Cells
1294:
1292:
1289:
1268:
1265:
1263:
1260:
1197:
1194:
1162:
1161:
1158:
1157:
1152:
1142:
1141:
1135:
1134:
1131:
1130:
1128:
1126:
1119:
1118:
1111:
1104:
1100:
1099:
1096:
1095:
1073:
1072:
1066:
1063:
1062:
1052:
1051:
1045:
1041:
1040:
1037:
1036:
1014:
1013:
1007:
1004:
1003:
993:
992:
986:
982:
981:
978:
977:
969:
968:
962:
959:
958:
950:
949:
943:
937:
936:
933:
932:
924:
923:
917:
914:
913:
905:
904:
898:
892:
891:
888:
887:
879:
878:
872:
869:
868:
860:
859:
853:
847:
846:
841:
836:
832:
831:
821:
820:
817:
816:
805:
804:
802:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
705:
703:
699:
698:
696:
695:
690:
685:
680:
675:
670:
664:
662:
658:
657:
655:
654:
649:
644:
639:
634:
629:
624:
619:
614:
609:
604:
599:
593:
591:
587:
586:
576:
575:
572:
571:
568:
567:
559:
558:
547:
541:
540:
537:
536:
528:
527:
524:
523:
521:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
477:
476:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
402:
401:
393:
382:
376:
375:
372:RNA expression
364:
363:
360:
359:
351:
347:
346:
338:
335:
330:
324:
323:
314:
307:
301:
297:
296:
291:
285:
284:
276:
275:
263:
262:
259:
258:
250:
246:
245:
237:
234:
229:
223:
222:
213:
206:
200:
196:
195:
188:
182:
181:
173:
172:
160:
159:
116:
112:
111:
103:
95:
94:
90:
89:
86:
85:
82:
81:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
4443:
4432:
4429:
4427:
4424:
4422:
4419:
4418:
4416:
4405:
4400:
4398:
4393:
4391:
4386:
4385:
4379:
4377:
4373:
4369:
4365:
4360:
4357:
4353:
4345:
4340:
4335:
4331:
4317:
4313:
4312:
4307:
4304:
4300:
4299:
4294:
4291:
4287:
4286:
4281:
4278:
4274:
4273:
4268:
4265:
4261:
4260:
4255:
4252:
4248:
4247:
4242:
4239:
4235:
4234:
4229:
4228:
4226:
4222:
4216:
4213:
4211:
4208:
4206:
4203:
4201:
4198:
4196:
4193:
4192:
4190:
4186:
4180:
4177:
4175:
4174:Enzyme family
4172:
4170:
4167:
4165:
4162:
4161:
4159:
4155:
4149:
4146:
4144:
4141:
4139:
4138:Cooperativity
4136:
4134:
4131:
4130:
4128:
4124:
4118:
4115:
4113:
4110:
4108:
4105:
4103:
4100:
4098:
4097:Oxyanion hole
4095:
4093:
4090:
4088:
4085:
4083:
4080:
4079:
4077:
4073:
4069:
4062:
4057:
4055:
4050:
4048:
4043:
4042:
4039:
4019:
4016:
4014:
4011:
4010:
4008:
4005:
4001:
3995:
3992:
3990:
3987:
3985:
3982:
3980:
3977:
3975:
3972:
3971:
3969:
3966:
3962:
3956:
3953:
3951:
3948:
3946:
3943:
3941:
3938:
3937:
3935:
3931:
3925:
3922:
3920:
3917:
3915:
3912:
3910:
3907:
3906:
3904:
3900:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3875:
3873:
3870:
3866:
3860:
3857:
3855:
3852:
3850:
3847:
3846:
3844:
3841:
3837:
3831:
3828:
3826:
3823:
3822:
3820:
3817:
3813:
3807:
3804:
3802:
3799:
3798:
3796:
3793:
3789:
3783:
3780:
3778:
3775:
3774:
3772:
3769:
3765:
3759:
3756:
3754:
3751:
3750:
3748:
3745:
3741:
3735:
3732:
3730:
3727:
3726:
3724:
3721:
3717:
3713:
3709:(EC 2.7.10.2)
3708:
3703:
3699:
3685:
3682:
3681:
3679:
3677:uncategorised
3675:
3669:
3666:
3665:
3663:
3660:
3656:
3650:
3647:
3645:
3642:
3640:
3637:
3636:
3634:
3631:
3627:
3621:
3618:
3616:
3613:
3612:
3610:
3607:
3603:
3597:
3594:
3593:
3591:
3587:
3581:
3578:
3577:
3575:
3572:
3571:MuSK receptor
3568:
3562:
3559:
3558:
3556:
3553:
3549:
3543:
3540:
3539:
3537:
3534:
3533:PTK7 receptor
3530:
3524:
3521:
3519:
3516:
3515:
3513:
3510:
3506:
3500:
3497:
3495:
3492:
3491:
3489:
3486:
3482:
3476:
3473:
3471:
3468:
3467:
3465:
3462:
3458:
3452:
3449:
3447:
3444:
3443:
3441:
3438:
3434:
3428:
3425:
3423:
3420:
3418:
3415:
3413:
3410:
3408:
3405:
3403:
3400:
3398:
3395:
3393:
3390:
3388:
3385:
3383:
3380:
3378:
3375:
3373:
3370:
3368:
3365:
3363:
3360:
3358:
3355:
3354:
3352:
3349:
3345:
3335:
3332:
3330:
3327:
3325:
3322:
3321:
3319:
3316:
3312:
3306:
3303:
3301:
3298:
3297:
3295:
3292:
3288:
3282:
3279:
3277:
3274:
3272:
3269:
3268:
3266:
3263:
3259:
3253:
3250:
3248:
3245:
3243:
3240:
3238:
3235:
3234:
3232:
3229:
3225:
3218:
3215:
3213:
3209:
3206:
3204:
3201:
3199:
3196:
3194:
3191:
3190:
3188:
3186:
3182:
3176:
3173:
3171:
3168:
3166:
3163:
3162:
3160:
3157:
3153:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3128:
3126:
3124:
3120:
3117:
3115:
3111:
3107:
3103:(EC 2.7.10.1)
3102:
3097:
3093:
3088:
3084:
3080:
3073:
3068:
3066:
3061:
3059:
3054:
3053:
3050:
3036:
3030:
3025:
3021:
3012:
3007:
3005:
3000:
2998:
2993:
2992:
2989:
2982:
2978:
2977:
2972:
2968:
2964:
2961:
2957:
2956:
2951:
2947:
2943:
2942:
2938:
2931:
2927:
2922:
2917:
2912:
2907:
2903:
2899:
2895:
2891:
2887:
2882:
2878:
2874:
2869:
2864:
2861:(6): 1842–9.
2860:
2856:
2852:
2847:
2843:
2839:
2834:
2829:
2826:(2): 607–17.
2825:
2821:
2817:
2812:
2808:
2804:
2799:
2794:
2790:
2786:
2782:
2777:
2773:
2769:
2765:
2761:
2758:(1): 247–51.
2757:
2753:
2747:
2743:
2739:
2735:
2731:
2727:
2723:
2719:
2715:
2710:
2706:
2702:
2697:
2692:
2689:(9): 3791–5.
2688:
2684:
2680:
2675:
2671:
2667:
2664:(4): 937–42.
2663:
2659:
2654:
2650:
2646:
2641:
2636:
2633:(5): 515–25.
2632:
2628:
2624:
2619:
2615:
2611:
2607:
2603:
2599:
2595:
2591:
2587:
2583:
2579:
2574:
2570:
2566:
2562:
2558:
2553:
2548:
2545:(5): 637–42.
2544:
2540:
2539:FASEB Journal
2536:
2531:
2527:
2523:
2520:(4): 619–25.
2519:
2515:
2510:
2506:
2502:
2497:
2492:
2488:
2484:
2480:
2476:
2472:
2467:
2463:
2459:
2455:
2451:
2446:
2442:
2438:
2433:
2428:
2425:(4): 373–82.
2424:
2420:
2416:
2411:
2407:
2403:
2399:
2395:
2391:
2387:
2382:
2381:
2376:
2367:
2363:
2358:
2353:
2349:
2345:
2341:
2334:
2331:
2326:
2322:
2317:
2312:
2308:
2304:
2300:
2293:
2290:
2285:
2281:
2277:
2273:
2269:
2265:
2261:
2257:
2250:
2247:
2242:
2238:
2233:
2228:
2224:
2220:
2216:
2209:
2206:
2201:
2197:
2192:
2187:
2183:
2179:
2175:
2171:
2167:
2160:
2157:
2152:
2148:
2143:
2138:
2134:
2130:
2126:
2122:
2118:
2111:
2109:
2105:
2100:
2096:
2091:
2086:
2081:
2076:
2072:
2068:
2064:
2060:
2056:
2049:
2047:
2043:
2032:
2028:
2022:
2019:
2014:
2010:
2006:
2002:
1998:
1994:
1991:(2): 87–103.
1990:
1986:
1979:
1977:
1975:
1973:
1969:
1964:
1960:
1956:
1952:
1948:
1944:
1937:
1935:
1933:
1931:
1929:
1927:
1925:
1923:
1919:
1914:
1910:
1906:
1902:
1898:
1894:
1891:(2): 133–54.
1890:
1886:
1879:
1877:
1875:
1873:
1871:
1869:
1867:
1865:
1863:
1859:
1854:
1850:
1846:
1842:
1838:
1834:
1830:
1826:
1819:
1817:
1815:
1813:
1811:
1809:
1807:
1805:
1803:
1799:
1794:
1788:
1785:
1780:
1776:
1772:
1768:
1761:
1758:
1753:
1749:
1743:
1740:
1735:
1731:
1725:
1722:
1718:
1714:
1709:
1707:
1705:
1701:
1697:
1693:
1688:
1686:
1684:
1680:
1673:
1667:
1664:
1661:
1658:
1655:
1652:
1649:
1646:
1643:
1640:
1637:
1634:
1633:
1631:
1629:
1621:
1619:
1612:
1610:
1608:
1604:
1600:
1598:
1593:
1589:
1585:
1581:
1577:
1573:
1569:
1567:
1563:
1559:
1551:
1547:
1546:downregulated
1543:
1542:degranulation
1539:
1534:
1530:
1526:
1522:
1515:
1513:
1511:
1507:
1503:
1499:
1495:
1491:
1484:
1476:
1474:
1472:
1468:
1464:
1460:
1455:
1452:
1448:
1444:
1440:
1436:
1432:
1427:
1425:
1421:
1417:
1413:
1409:
1406:
1402:
1398:
1391:Myeloid Cells
1390:
1388:
1386:
1382:
1378:
1374:
1369:
1367:
1363:
1359:
1355:
1351:
1346:
1342:
1337:
1335:
1332:
1328:
1323:
1319:
1315:
1311:
1307:
1303:
1302:naïve T cells
1295:
1290:
1288:
1286:
1282:
1278:
1274:
1266:
1261:
1259:
1257:
1253:
1252:
1247:
1243:
1239:
1235:
1233:
1229:
1226:produces two
1225:
1221:
1219:
1215:
1211:
1208:(SH) domains
1207:
1203:
1195:
1193:
1191:
1187:
1186:T-helper cell
1183:
1182:hematopoietic
1179:
1176:
1172:
1168:
1156:
1151:
1147:
1143:
1140:
1136:
1129:
1127:
1124:
1120:
1116:
1112:
1109:
1105:
1101:
1094:
1092:
1088:
1084:
1080:
1074:
1070:
1067:
1061:
1059:
1053:
1049:
1046:
1042:
1035:
1033:
1029:
1025:
1021:
1015:
1011:
1008:
1002:
1000:
994:
990:
987:
985:RefSeq (mRNA)
983:
976:
975:
970:
966:
963:
957:
956:
951:
947:
944:
942:
938:
931:
930:
925:
921:
918:
912:
911:
906:
902:
899:
897:
893:
886:
885:
880:
876:
873:
867:
866:
861:
857:
854:
852:
848:
845:
842:
840:
837:
833:
830:
826:
822:
815:
811:
806:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
706:
704:
701:
700:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
665:
663:
660:
659:
653:
652:lipid binding
650:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
598:
595:
594:
592:
589:
588:
585:
584:Gene ontology
581:
577:
565:
560:
556:
551:
548:
546:
542:
534:
529:
518:
514:
510:
506:
502:
498:
494:
490:
486:
483:sciatic nerve
482:
481:
478:
474:
469:
466:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
403:
400:
398:
394:
392:
391:
387:
386:
383:
381:
377:
373:
369:
365:
357:
352:
348:
344:
339:
329:
325:
318:
311:
305:
298:
290:
286:
282:
277:
273:
268:
264:
256:
251:
247:
243:
238:
228:
224:
217:
210:
204:
197:
193:
187:
183:
179:
174:
170:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
113:
108:
101:
96:
91:
80:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
4376:expanding it
4368:chromosome 4
4361:
4311:Translocases
4308:
4295:
4282:
4269:
4256:
4246:Transferases
4243:
4230:
4087:Binding site
3973:
3964:
3933:SRC-B family
3902:SRC-A family
3659:RET receptor
3630:AXL receptor
3552:RYK receptor
3509:DDR receptor
3485:ROR receptor
3461:TIE receptor
3437:LTK receptor
3348:EPH receptor
3315:Trk receptor
3291:HGF receptor
3228:FGF receptor
3034:
2974:
2953:
2893:
2889:
2858:
2854:
2823:
2819:
2791:(3): 940–8.
2788:
2784:
2755:
2751:
2717:
2713:
2686:
2682:
2661:
2657:
2630:
2626:
2581:
2577:
2542:
2538:
2517:
2513:
2478:
2474:
2453:
2449:
2422:
2418:
2389:
2385:
2347:
2343:
2333:
2306:
2302:
2292:
2259:
2255:
2249:
2222:
2218:
2208:
2173:
2169:
2159:
2124:
2120:
2065:(2): 733–8.
2062:
2058:
2034:. Retrieved
2030:
2021:
1988:
1984:
1946:
1942:
1888:
1884:
1831:(1): 65–78.
1828:
1824:
1787:
1770:
1766:
1760:
1751:
1742:
1733:
1724:
1625:
1622:Interactions
1616:
1602:
1601:
1584:granulocytes
1570:
1519:
1496:activity. A
1480:
1456:
1428:
1394:
1370:
1338:
1299:
1270:
1249:
1245:
1237:
1236:
1223:
1222:
1206:Src homology
1199:
1174:
1166:
1165:
1087:NP_001106935
1083:NP_001106932
1079:NP_001106931
1076:
1055:
1028:NM_001113464
1024:NM_001113461
1020:NM_001113460
1017:
996:
972:
953:
927:
908:
882:
863:
843:
838:
688:cytoskeleton
515:right kidney
395:
388:
115:External IDs
74:
15:
4082:Active site
3017:PDB gallery
1574:(CML) is a
1558:phosphatase
1523:(RA) is an
1459:neutrophils
1401:macrophages
1240:resides on
647:ATP binding
511:bone marrow
487:granulocyte
433:skin of leg
354:73,025,826
341:72,913,059
253:48,269,838
240:48,135,783
93:Identifiers
4415:Categories
4285:Isomerases
4259:Hydrolases
4126:Regulation
2036:2021-03-06
1719:, May 2017
1698:, May 2017
1674:References
1477:Activation
1467:mast cells
1242:chromosome
453:right lung
399:(ortholog)
136:HomoloGene
18:Human gene
4366:on human
4164:EC number
2142:1765/9530
2013:207475386
1613:Discovery
1592:histamine
1588:Dasatinib
1582:in which
1471:erythroid
1431:platelets
1381:phenotype
1366:pathogens
1196:Structure
1091:NP_038717
1058:NP_003206
1032:NM_013689
999:NM_003215
829:Orthologs
668:cytoplasm
144:GeneCards
4188:Kinetics
4112:Cofactor
4075:Activity
2930:10518561
2877:10382746
2714:Oncogene
2658:Oncogene
2627:Immunity
2614:42666246
2569:27064487
2514:Oncogene
2450:Oncogene
2441:10795735
2419:Immunity
2406:10647781
2256:Oncogene
2241:11825908
2151:11071635
2099:12515866
2005:22449071
1963:10647781
1905:22449074
1853:30963664
1845:15133303
1767:Leukemia
1715:–
1694:–
1636:ARHGEF12
1628:interact
1498:tyrosine
1439:collagen
1435:thrombin
1341:T-helper
1334:cytokine
1285:integrin
1277:antigens
1262:Function
1139:Wikidata
808:Sources:
678:membrane
441:monocyte
429:testicle
232:4p12-p11
4344:Biology
4298:Ligases
4068:Enzymes
3089:2.7.10)
2981:PDBe-KB
2971:UniProt
2960:PDBe-KB
2950:UniProt
2898:Bibcode
2842:9872994
2807:9446655
2772:9299487
2742:7999440
2734:9178903
2705:8892607
2670:8632917
2649:8630736
2606:8629002
2586:Bibcode
2578:Science
2561:8621063
2526:7651724
2505:7526158
2462:2284097
2366:9341160
2325:9473212
2284:7999440
2276:9178903
2200:7526158
2067:Bibcode
1913:1636844
1779:7934162
1717:Ensembl
1696:Ensembl
1578:of the
1560:enzyme
1373:B cells
941:UniProt
896:Ensembl
835:Species
814:QuickGO
673:cytosol
374:pattern
100:Aliases
4330:Portal
4272:Lyases
4006:family
3967:family
3871:family
3842:family
3818:family
3794:family
3770:family
3746:family
3722:family
3661:family
3632:family
3620:AATYK2
3608:family
3573:family
3554:family
3535:family
3511:family
3487:family
3463:family
3439:family
3350:family
3317:family
3293:family
3281:VEGFR3
3276:VEGFR2
3271:VEGFR1
3264:family
3230:family
3217:PDGFRB
3212:PDGFRA
3158:family
2976:P24604
2955:P42680
2928:
2918:
2875:
2840:
2805:
2770:
2740:
2732:
2703:
2668:
2647:
2612:
2604:
2567:
2559:
2524:
2503:
2496:359382
2493:
2460:
2439:
2404:
2364:
2323:
2282:
2274:
2239:
2198:
2191:359382
2188:
2149:
2097:
2090:141065
2087:
2011:
2003:
1961:
1911:
1903:
1851:
1843:
1777:
1662:, and
1630:with:
1576:cancer
1552:of PIP
1424:IRAK-1
1422:, and
1360:, and
1358:IL-23R
1354:IL-17F
1350:IL-17A
1306:T-cell
1218:kinase
1216:and a
1125:search
1123:PubMed
974:P24604
955:P42680
851:Entrez
545:BioGPS
491:spleen
449:rectum
124:600583
4370:is a
4224:Types
4018:ZAP70
3684:STYK1
3649:TYRO3
3615:AATYK
3422:EPHB6
3417:EPHB5
3412:EPHB4
3407:EPHB3
3402:EPHB2
3397:EPHB1
3392:EPHA8
3387:EPHA7
3382:EPHA6
3377:EPHA5
3372:EPHA4
3367:EPHA3
3362:EPHA2
3357:EPHA1
3334:NTRK3
3329:NTRK2
3324:NTRK1
3252:FGFR4
3247:FGFR3
3242:FGFR2
3237:FGFR1
3208:PDGFR
3193:CSF1R
3175:INSRR
3165:IGF1R
3146:ERBB4
3141:ERBB3
3136:ERBB2
2921:18397
2785:Blood
2738:S2CID
2610:S2CID
2565:S2CID
2303:Blood
2280:S2CID
2121:Blood
2009:S2CID
1909:S2CID
1849:S2CID
1654:GNA12
1642:CD117
1566:SHP-1
1494:PI3-K
1443:PLCγ2
1420:MyD88
1408:TNF-α
1362:RORγt
1169:is a
884:21682
844:Mouse
839:Human
810:Amigo
503:blood
421:gonad
397:Mouse
390:Human
337:Start
272:Mouse
236:Start
169:Human
132:98662
4372:stub
4364:gene
4316:list
4309:EC7
4303:list
4296:EC6
4290:list
4283:EC5
4277:list
4270:EC4
4264:list
4257:EC3
4251:list
4244:EC2
4238:list
4231:EC1
3924:YES1
3893:TYK2
3888:JAK3
3883:JAK2
3878:JAK1
3859:SRMS
3806:PYK2
3782:MATK
3758:TNK1
3753:ACK1
3729:ABL1
3596:ROS1
3580:MUSK
3542:PTK7
3523:DDR2
3518:DDR1
3499:ROR2
3494:ROR1
3427:EPHX
3198:FLT3
3170:INSR
3131:EGFR
3035:1gl5
2969:for
2948:for
2926:PMID
2873:PMID
2838:PMID
2803:PMID
2768:PMID
2730:PMID
2701:PMID
2666:PMID
2645:PMID
2602:PMID
2557:PMID
2522:PMID
2501:PMID
2458:PMID
2437:PMID
2402:PMID
2362:PMID
2321:PMID
2272:PMID
2237:PMID
2196:PMID
2147:PMID
2095:PMID
2001:PMID
1959:PMID
1901:PMID
1841:PMID
1775:PMID
1648:DOK1
1562:SHIP
1469:and
1463:fMLP
1447:GPVI
1416:TLR4
1412:IL-6
1410:and
1345:Th17
1331:IL-4
1329:and
1327:IL-2
1322:CD28
1310:IL-6
1212:and
1178:gene
865:7006
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