1021:
5β²-upstream CpG island are methylated in a number of cancers. An inverse correlation between TMEFF2 methylation and the stage, response to therapy and survival outcome has been observed. The detection of methylated free-circulating TMEFF2 DNA has been suggested as a potential diagnostic tool for colorectal cancer. The TMEFF2 downregulation signature equals and sometimes outperforms the
Gleason and pathological scores in prostate cancer. TMEFF2 is downregulated in glioma and cotricotropinomas, and it impairs the production of adrenocorticotropic hormone in glioma cells. Through binding the amyloid Ξ² protein, its precursor and derivatives, TMEFF2 provides neuroprotection in Alzheimer's disease.
297:
274:
171:
196:
303:
202:
1723:
1568:
Sabbioni S, Miotto E, Veronese A, Sattin E, Gramantieri L, Bolondi L, Calin GA, GafΓ R, Lanza G, Carli G, Ferrazzi E, Feo C, Liboni A, Gullini S, Negrini M (2004). "Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that
1016:
is located on chromosome 2q32-q33 and encodes a 374-residue long single polypeptide, type-I transmembrane proteoglycan. According to the HUGO gene nomenclature committee, the aliases of TMEFF2 include,HPP1, Tomoregulin (TR), Transmembrane protein TENB2 (TENB2), Cancer/testis antigen family 120,
1024:
TMEFF2 is a multidomain protein with its N-terminus harbouring a signal peptide followed by two follistatin-like domains, an EGF (epidermal growth factor)-like domain, a transmembrane portion and a short intracellular domain. The EGF-like domain of TMEFF2 appears to be functionally ineffective
1020:
TMEFF2 is proteolytically shed from the cell surface. The reported functions of TMEFF2 span across a wide range of physiological and pathological spectra including metabolism, neuroprotection, apoptosis, embryonic development, onco-suppression and endocrine function. TMEFF2 promoter and its
1517:
Sato F, Shibata D, Harpaz N, Xu Y, Yin J, Mori Y, Wang S, Olaru A, Deacu E, Selaru FM, Kimos MC, Hytiroglou P, Young J, Leggett B, Gazdar AF, Toyooka S, Abraham JM, Meltzer SJ (December 2002). "Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma".
1193:
Horie M, Mitsumoto Y, Kyushiki H, Kanemoto N, Watanabe A, Taniguchi Y, Nishino N, Okamoto T, Kondo M, Mori T, Noguchi K, Nakamura Y, Takahashi EI, Tanigami A (July 2000). "Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons".
50:
1677:
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007).
1351:
Uchida T, Wada K, Akamatsu T, Yonezawa M, Noguchi H, Mizoguchi A, Kasuga M, Sakamoto C (December 1999). "A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells".
1495:
Shibata DM, Sato F, Mori Y, Perry K, Yin J, Wang S, Xu Y, Olaru A, Selaru F, Spring K, Young J, Abraham JM, Meltzer SJ (October 2002). "Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas".
1381:
Liang G, Robertson KD, Talmadge C, Sumegi J, Jones PA (September 2000). "The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells".
1017:
member 2 (CT120.2) and
Transmembrane protein containing EGF and follistatin domains (TPEF). TMEFF2 was identified and characterized by at least five independent groups within the time span of approximately a year.
1641:
Schulmann K, Sterian A, Berki A, Yin J, Sato F, Xu Y, Olaru A, Wang S, Mori Y, Deacu E, Hamilton J, Kan T, Krasna MJ, Beer DG, Pepe MS, Abraham JM, Feng Z, Schmiegel W, Greenwald BD, Meltzer SJ (June 2005).
1025:
because of the substitution of a crucial arginine residue (Arg39) with histidine, whereas the follistatin-like domains are reported to be crucial for the relevant functions of TMEFF2 .
1322:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
310:
209:
1680:"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries"
737:
718:
132:
1293:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
1792:
1768:
1102:
1084:
1787:
953:
296:
960:
273:
1229:
1644:"Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk"
1071:
1050:
1067:
1454:"TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence"
195:
170:
47:
1046:
112:
309:
208:
1452:
Glynne-Jones E, Harper ME, Seery LT, James R, Anglin I, Morgan HE, Taylor KM, Gee JM, Nicholson RI (October 2001).
302:
201:
1761:
782:
120:
103:, CT120.2, HPP1, TENB2, TPEF, TR, TR-2, transmembrane protein with EGF like and two follistatin like domains 2
1404:
763:
1754:
184:
99:
911:
907:
856:
852:
1409:"HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers"
1483:
144:
1407:, Herath N, Barker M, Anderson GJ, Fitzpatrick DR, Ramm GA, Jass JR, Leggett BA (January 2001).
936:
915:
881:
860:
1701:
1665:
1629:
1586:
1556:
1527:
1505:
1475:
1440:
1391:
1369:
1339:
1310:
1281:
1211:
1158:
92:
40:
1738:
1691:
1655:
1619:
1611:
1578:
1548:
1465:
1430:
1420:
1361:
1331:
1302:
1271:
1261:
1230:"Entrez Gene: TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2"
1203:
1148:
1138:
389:
320:
264:
219:
140:
364:
1624:
1600:"Signal peptide prediction based on analysis of experimentally verified cleavage sites"
1599:
1276:
1249:
1153:
1126:
1012:
The
Transmembrane protein with an EGF-like and two follistatin-like domains 2 (TMEFF2)
1552:
1335:
1250:"TMEFF2: A Transmembrane Proteoglycan with Multifaceted Actions in Cancer and Disease"
1127:"TMEFF2: A Transmembrane Proteoglycan with Multifaceted Actions in Cancer and Disease"
652:
647:
642:
637:
632:
627:
611:
606:
601:
596:
580:
1781:
1582:
1435:
1408:
1306:
567:
1487:
124:
1734:
382:
161:
148:
1107:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1089:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1413:
Proceedings of the
National Academy of Sciences of the United States of America
465:
1696:
1679:
1539:
Gery S, Koeffler HP (May 2003). "Repression of the TMEFF2 promoter by c-Myc".
281:
178:
128:
1266:
1143:
682:
525:
403:
348:
335:
247:
234:
136:
1705:
1669:
1660:
1643:
1633:
1590:
1560:
1531:
1509:
1479:
1444:
1425:
1395:
1373:
1365:
1285:
1215:
1207:
1162:
1343:
1314:
1000:
995:
984:
827:
808:
1615:
794:
749:
69:
1470:
1453:
968:
704:
1722:
667:
663:
1730:
1179:
1013:
116:
1403:
Young J, Biden KG, Simms LA, Huggard P, Karamatic R, Eyre HJ,
1248:
Masood M, Grimm S, El-Bahrawy M, YagΓΌe E (December 2020).
1125:
Masood M, Grimm S, El-Bahrawy M, YagΓΌe E (December 2020).
372:
1742:
537:
628:
negative regulation of integrin biosynthetic process
1354:
929:
900:
874:
845:
1063:
1061:
1059:
1042:
1040:
1038:
319:
218:
1120:
1118:
1116:
16:Protein-coding gene in the species Homo sapiens
1174:
1172:
1068:GRCm38: Ensembl release 89: ENSMUSG00000026109
1762:
8:
638:negative regulation of stress fiber assembly
1047:GRCh38: Ensembl release 89: ENSG00000144339
1769:
1755:
678:
563:
360:
259:
156:
58:
1695:
1659:
1623:
1469:
1434:
1424:
1275:
1265:
1152:
1142:
1034:
1569:can be detected in peripheral blood".
18:
633:negative regulation of cell migration
324:
285:
280:
223:
182:
177:
7:
1719:
1717:
1598:Zhang Z, Henzel WJ (October 2004).
1741:. You can help Knowledge (XXG) by
926:
897:
871:
842:
818:
799:
773:
754:
728:
709:
542:
460:
398:
377:
14:
643:wound healing, spreading of cells
1721:
1583:10.2165/00066982-200307030-00010
308:
301:
295:
272:
207:
200:
194:
169:
1458:International Journal of Cancer
597:integral component of membrane
526:More reference expression data
1:
1793:Human chromosome 2 gene stubs
1553:10.1016/S0022-2836(03)00404-2
1336:10.1016/S0378-1119(97)00411-3
293:
192:
1541:Journal of Molecular Biology
1307:10.1016/0378-1119(94)90802-8
476:anterior horn of spinal cord
1788:Genes on human chromosome 2
1809:
1716:
1180:"TMEFF2 Encyclopedia MDPI"
648:animal organ morphogenesis
1103:"Mouse PubMed Reference:"
1085:"Human PubMed Reference:"
999:
994:
990:
983:
967:
954:Chr 2: 191.95 β 192.19 Mb
948:
933:
904:
893:
878:
849:
838:
825:
821:
806:
802:
793:
780:
776:
761:
757:
748:
735:
731:
716:
712:
703:
688:
681:
677:
661:
566:
562:
550:
545:
536:
523:
472:
463:
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
484:anterior amygdaloid area
1697:10.1093/dnares/12.2.117
1267:10.3390/cancers12123862
1144:10.3390/cancers12123862
961:Chr 1: 50.94 β 51.23 Mb
1661:10.1038/sj.onc.1208598
1426:10.1073/pnas.011415298
1366:10.1006/bbrc.1999.1873
1208:10.1006/geno.2000.6228
512:deep cerebellar nuclei
504:ventral tegmental area
414:middle temporal gyrus
602:extracellular region
500:lateral hypothalamus
480:facial motor nucleus
287:Chromosome 1 (mouse)
185:Chromosome 2 (human)
62:List of PDB id codes
35:Available structures
1616:10.1110/ps.04682504
1571:Molecular Diagnosis
446:subthalamic nucleus
1729:This article on a
783:ENSMUSG00000026109
653:tissue development
621:Biological process
590:Cellular component
581:molecular function
574:Molecular function
488:supraoptic nucleus
149:TMEFF2 - orthologs
1750:
1749:
1010:
1009:
1006:
1005:
979:
978:
944:
943:
923:
922:
889:
888:
868:
867:
834:
833:
815:
814:
789:
788:
770:
769:
744:
743:
725:
724:
673:
672:
558:
557:
554:
553:
532:
531:
519:
518:
457:
456:
438:entorhinal cortex
355:
354:
254:
253:
81:
80:
77:
76:
45:Ortholog search:
1800:
1771:
1764:
1757:
1725:
1718:
1709:
1699:
1673:
1663:
1637:
1627:
1594:
1564:
1535:
1513:
1491:
1473:
1471:10.1002/ijc.1450
1448:
1438:
1428:
1399:
1377:
1347:
1318:
1289:
1279:
1269:
1234:
1233:
1226:
1220:
1219:
1190:
1184:
1183:
1176:
1167:
1166:
1156:
1146:
1122:
1111:
1110:
1099:
1093:
1092:
1081:
1075:
1065:
1054:
1044:
992:
991:
963:
956:
939:
927:
918:
898:
894:RefSeq (protein)
884:
872:
863:
843:
819:
800:
774:
755:
729:
710:
679:
564:
543:
528:
468:
466:Top expressed in
461:
450:endothelial cell
426:Brodmann area 23
418:Brodmann area 46
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
1808:
1807:
1803:
1802:
1801:
1799:
1798:
1797:
1778:
1777:
1776:
1775:
1714:
1712:
1676:
1654:(25): 4138β48.
1640:
1610:(10): 2819β24.
1604:Protein Science
1597:
1567:
1538:
1520:Cancer Research
1516:
1504:(20): 5637β40.
1498:Cancer Research
1494:
1451:
1402:
1390:(17): 4907β12.
1384:Cancer Research
1380:
1350:
1330:(1β2): 149β56.
1321:
1292:
1247:
1243:
1241:Further reading
1238:
1237:
1228:
1227:
1223:
1192:
1191:
1187:
1178:
1177:
1170:
1124:
1123:
1114:
1101:
1100:
1096:
1083:
1082:
1078:
1066:
1057:
1045:
1036:
1031:
1001:View/Edit Mouse
996:View/Edit Human
959:
952:
949:Location (UCSC)
935:
914:
910:
906:
880:
859:
855:
851:
764:ENSG00000144339
657:
616:
612:plasma membrane
585:
524:
515:
510:
508:globus pallidus
506:
502:
498:
494:
490:
486:
482:
478:
464:
453:
448:
444:
442:corpus callosum
440:
436:
434:pars reticulata
432:
428:
424:
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
1806:
1804:
1796:
1795:
1790:
1780:
1779:
1774:
1773:
1766:
1759:
1751:
1748:
1747:
1726:
1711:
1710:
1674:
1638:
1595:
1577:(3β4): 201β7.
1565:
1536:
1526:(23): 6820β2.
1514:
1492:
1449:
1400:
1378:
1360:(2): 593β602.
1348:
1319:
1301:(1β2): 171β4.
1290:
1244:
1242:
1239:
1236:
1235:
1221:
1185:
1168:
1112:
1094:
1076:
1055:
1033:
1032:
1030:
1027:
1008:
1007:
1004:
1003:
998:
988:
987:
981:
980:
977:
976:
974:
972:
965:
964:
957:
950:
946:
945:
942:
941:
931:
930:
924:
921:
920:
902:
901:
895:
891:
890:
887:
886:
876:
875:
869:
866:
865:
847:
846:
840:
836:
835:
832:
831:
823:
822:
816:
813:
812:
804:
803:
797:
791:
790:
787:
786:
778:
777:
771:
768:
767:
759:
758:
752:
746:
745:
742:
741:
733:
732:
726:
723:
722:
714:
713:
707:
701:
700:
695:
690:
686:
685:
675:
674:
671:
670:
659:
658:
656:
655:
650:
645:
640:
635:
630:
624:
622:
618:
617:
615:
614:
609:
604:
599:
593:
591:
587:
586:
584:
583:
577:
575:
571:
570:
560:
559:
556:
555:
552:
551:
548:
547:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
473:
470:
469:
458:
455:
454:
452:
451:
447:
443:
439:
435:
431:
427:
423:
422:spinal ganglia
419:
415:
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
284:
278:
277:
269:
268:
256:
255:
252:
251:
243:
239:
238:
230:
227:
222:
216:
215:
206:
199:
193:
189:
188:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1805:
1794:
1791:
1789:
1786:
1785:
1783:
1772:
1767:
1765:
1760:
1758:
1753:
1752:
1746:
1744:
1740:
1736:
1732:
1727:
1724:
1720:
1715:
1707:
1703:
1698:
1693:
1690:(2): 117β26.
1689:
1685:
1681:
1675:
1671:
1667:
1662:
1657:
1653:
1649:
1645:
1639:
1635:
1631:
1626:
1621:
1617:
1613:
1609:
1605:
1601:
1596:
1592:
1588:
1584:
1580:
1576:
1572:
1566:
1562:
1558:
1554:
1550:
1547:(5): 977β83.
1546:
1542:
1537:
1533:
1529:
1525:
1521:
1515:
1511:
1507:
1503:
1499:
1493:
1489:
1485:
1481:
1477:
1472:
1467:
1464:(2): 178β84.
1463:
1459:
1455:
1450:
1446:
1442:
1437:
1432:
1427:
1422:
1419:(1): 265β70.
1418:
1414:
1410:
1406:
1405:Sutherland GR
1401:
1397:
1393:
1389:
1385:
1379:
1375:
1371:
1367:
1363:
1359:
1355:
1349:
1345:
1341:
1337:
1333:
1329:
1325:
1320:
1316:
1312:
1308:
1304:
1300:
1296:
1291:
1287:
1283:
1278:
1273:
1268:
1263:
1259:
1255:
1251:
1246:
1245:
1240:
1231:
1225:
1222:
1217:
1213:
1209:
1205:
1202:(2): 146β52.
1201:
1197:
1189:
1186:
1181:
1175:
1173:
1169:
1164:
1160:
1155:
1150:
1145:
1140:
1136:
1132:
1128:
1121:
1119:
1117:
1113:
1108:
1104:
1098:
1095:
1090:
1086:
1080:
1077:
1073:
1069:
1064:
1062:
1060:
1056:
1052:
1048:
1043:
1041:
1039:
1035:
1028:
1026:
1022:
1018:
1015:
1002:
997:
993:
989:
986:
982:
975:
973:
970:
966:
962:
958:
955:
951:
947:
940:
938:
932:
928:
925:
919:
917:
913:
909:
903:
899:
896:
892:
885:
883:
877:
873:
870:
864:
862:
858:
854:
848:
844:
841:
839:RefSeq (mRNA)
837:
830:
829:
824:
820:
817:
811:
810:
805:
801:
798:
796:
792:
785:
784:
779:
775:
772:
766:
765:
760:
756:
753:
751:
747:
740:
739:
734:
730:
727:
721:
720:
715:
711:
708:
706:
702:
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569:
568:Gene ontology
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511:
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326:1|1 C1.1
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1743:expanding it
1735:chromosome 2
1728:
1713:
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1684:DNA Research
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1327:
1323:
1298:
1294:
1260:(12): 3862.
1257:
1253:
1224:
1199:
1195:
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1137:(12): 3862.
1134:
1130:
1106:
1097:
1088:
1079:
1023:
1019:
1011:
934:
912:NP_001292074
908:NP_001292063
905:
879:
857:NM_001305145
853:NM_001305134
850:
826:
807:
781:
762:
736:
717:
697:
692:
388:
381:
246:192,194,933
233:191,949,043
108:External IDs
67:
492:optic nerve
347:51,226,429
334:50,939,806
86:Identifiers
1782:Categories
1074:, May 2017
1053:, May 2017
1029:References
392:(ortholog)
129:HomoloGene
1733:on human
937:NP_062764
916:NP_057276
882:NM_019790
861:NM_016192
683:Orthologs
137:GeneCards
1706:16303743
1670:15824739
1648:Oncogene
1634:15340161
1591:15068392
1561:12729735
1532:12460892
1510:12384516
1488:22411392
1480:11668495
1445:11120884
1396:10987305
1374:10600548
1286:33371267
1216:10903839
1196:Genomics
1163:33371267
1070:–
1049:–
985:Wikidata
662:Sources:
607:membrane
496:habenula
430:thalamus
1625:2286551
1344:9373149
1315:8125298
1277:7766544
1254:Cancers
1154:7766544
1131:Cancers
1072:Ensembl
1051:Ensembl
795:UniProt
750:Ensembl
689:Species
668:QuickGO
367:pattern
125:1861735
93:Aliases
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1161:
1151:
971:search
969:PubMed
828:Q9QYM9
809:Q9UIK5
705:Entrez
538:BioGPS
225:2q32.3
141:TMEFF2
117:605734
100:TMEFF2
22:TMEFF2
1737:is a
1484:S2CID
1436:14579
738:56363
719:23671
698:Mouse
693:Human
664:Amigo
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
1739:stub
1731:gene
1702:PMID
1666:PMID
1630:PMID
1587:PMID
1557:PMID
1528:PMID
1506:PMID
1476:PMID
1441:PMID
1392:PMID
1370:PMID
1340:PMID
1324:Gene
1311:PMID
1295:Gene
1282:PMID
1212:PMID
1159:PMID
1014:gene
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
133:9417
113:OMIM
70:2FMW
51:RCSB
48:PDBe
1692:doi
1656:doi
1620:PMC
1612:doi
1579:doi
1549:doi
1545:328
1466:doi
1431:PMC
1421:doi
1362:doi
1358:266
1332:doi
1328:200
1303:doi
1299:138
1272:PMC
1262:doi
1204:doi
1149:PMC
1139:doi
546:n/a
343:End
242:End
145:OMA
121:MGI
41:PDB
1784::
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1037:^
666:/
349:bp
336:bp
248:bp
235:bp
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