1114:
full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. Specifically, activation of TNFRSF25 is dependent upon previous engagement of the T cell receptor. Following binding to TL1A, TNFRSF25 signaling increases the sensitivity of T cells to endogenous IL-2 via the IL-2 receptor and enhances T cell proliferation. Because the activation of the receptor is T cell receptor dependent, the activity of TNFRSF25 in vivo is specific to those T cells that are encountering cognate antigen. At rest, and for individuals without underlying autoimmunity, the majority of T cells that regularly encounter cognate antigen are FoxP3+ regulatory T cells. Stimulation of TNFRSF25, in the absence of any other exogenous signals, stimulates profound and highly specific proliferation of FoxP3+ regulatory T cells from their 8-10% of all CD4+ T cells to 35-40% of all CD4+ T cells within 5 days.
1138:. Similarly, because TNFRSF25 activation is antigen dependent, costimulation of TNFRSF25 together with an autoantigen or with a vaccine antigen can lead to exacerbation of immunopathology or enhanced vaccine-stimulated immunity, respectively. TNFRSF25 stimulation is therefore highly specific to T cell mediated immunity, which can be used to enhance or dampen inflammation depending on the temporal context and quality of foreign vs self antigen availability. Stimulation of TNFRSF25 in humans may lead to similar, but more controllable, effects as coinhibitory receptor blockade targeting molecules such as
255:
232:
129:
154:
261:
160:
1101:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially by activated and antigen-experienced T lymphocytes. TNFRSF25 is also highly expressed by FoxP3 positive regulatory T lymphocytes. TNFRSF25 is activated by a monogamous ligand, known
1113:
Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces
1984:
Migone TS, Zhang J, Luo X, Zhuang L, Chen C, Hu B, Hong JS, Perry JW, Chen SF, Zhou JX, Cho YH, Ullrich S, Kanakaraj P, Carrell J, Boyd E, Olsen HS, Hu G, Pukac L, Liu D, Ni J, Kim S, Gentz R, Feng P, Moore PA, Ruben SM, Wei P (Mar 2002).
1102:
as TL1A (TNFSF15), which is rapidly upregulated in antigen presenting cells and some endothelial cells following Toll-Like
Receptor or Fc receptor activation. This receptor has been shown to signal both through the
2143:
Osawa K, Takami N, Shiozawa K, Hashiramoto A, Shiozawa S (Sep 2004). "Death receptor 3 (DR3) gene duplication in a chromosome region 1p36.3: gene duplication is more prevalent in rheumatoid arthritis".
1641:
Chinnaiyan AM, O'Rourke K, Yu GL, Lyons RH, Garg M, Duan DR, Xing L, Gentz R, Ni J, Dixit VM (Nov 1996). "Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95".
3447:
2806:
3231:
1825:
Warzocha K, Ribeiro P, Charlot C, Renard N, Coiffier B, Salles G (Jan 1998). "A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas".
1240:
Bodmer JL, Burns K, Schneider P, Hofmann K, Steiner V, Thome M, Bornand T, Hahne M, Schröter M, Becker K, Wilson A, French LE, Browning JL, MacDonald HR, Tschopp J (Jan 1997).
268:
167:
61:, APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR, tumor necrosis factor receptor superfamily member 25, TNF receptor superfamily member 25, GEF720, PLEKHG5
3463:
3925:
1854:
Grenet J, Valentine V, Kitson J, Li H, Farrow SN, Kidd VJ (May 1998). "Duplication of the DR3 gene on human chromosome 1p36 and its deletion in human neuroblastoma".
1284:
Kitson J, Raven T, Jiang YP, Goeddel DV, Giles KM, Pun KT, Grinham CJ, Brown R, Farrow SN (Nov 1996). "A death-domain-containing receptor that mediates apoptosis".
3391:
2929:
3513:
3945:
2216:
3573:
3224:
2184:
735:
90:
716:
2606:
3916:
3905:
3881:
3371:
3177:
2895:
2891:
2874:
3260:
3008:
2983:
2847:
3407:
3217:
3012:
2987:
2838:
1222:
1204:
4300:
3539:
3165:
2864:
2799:
2859:
1883:
Jiang Y, Woronicz JD, Liu W, Goeddel DV (Jan 1999). "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains".
254:
3271:
1006:
4225:
1955:
Frankel SK, Van Linden AA, Riches DW (Oct 2001). "Heterogeneity in the phosphorylation of human death receptors by p42(mapk/erk2)".
1604:
Metheny-Barlow LJ, Li LY (2006). "Vascular endothelial growth inhibitor (VEGI), an endogenous negative regulator of angiogenesis".
1453:
J Reddy PB, Schreiber TH, Rajasagi NK, Suryawanshi A, Mulik S, Veiga-Parga T, Niki T, Hirashima M, Podack ER, Rouse BT (Oct 2012).
999:
231:
1723:"Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B"
2738:
2443:
2435:
2209:
1455:"TNFRSF25 agonistic antibody and galectin-9 combination therapy controls herpes simplex virus-induced immunoinflammatory lesions"
1338:
3086:
2384:
1191:
1170:
3936:
3638:
3081:
3029:
2420:
1078:
1242:"TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)"
1187:
153:
128:
2333:
2295:
2290:
1166:
4305:
4240:
2338:
2022:"Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants"
267:
166:
70:
3050:
3046:
2202:
2751:
260:
159:
4230:
3872:
3066:
2682:
2238:
3831:
3301:
3042:
2966:
2665:
2451:
3196:
3160:
2691:
1920:
Kaptein A, Jansen M, Dilaver G, Kitson J, Dash L, Wang E, Owen MJ, Bodmer JL, Tschopp J, Farrow SN (Nov 2000).
780:
78:
3584:
3280:
3115:
3093:
3017:
3004:
2991:
2979:
2947:
2934:
2924:
2900:
2887:
2843:
2834:
2761:
2734:
2725:
2320:
761:
3296:
1774:"LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing"
1399:
1397:
3969:
3152:
3076:
2829:
2795:
2786:
2756:
2747:
2730:
2328:
2248:
1404:
Schreiber TH, Wolf D, Tsai MS, Chirinos J, Deyev VV, Gonzalez L, Malek TR, Levy RB, Podack ER (Oct 2010).
3781:
3776:
3727:
2854:
1074:
3366:
1721:
Marsters SA, Sheridan JP, Donahue CJ, Pitti RM, Gray CL, Goddard AD, Bauer KD, Ashkenazi A (Dec 1996).
3381:
2065:"TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells"
3896:
3732:
3437:
3331:
2974:
2882:
2824:
2781:
2708:
1892:
1785:
1734:
1650:
1293:
1086:
142:
57:
4139:
3847:
3737:
3629:
3346:
3341:
3336:
3326:
3191:
3186:
3024:
1131:
1090:
937:
913:
846:
3600:
3458:
3427:
3761:
3756:
3722:
3717:
3663:
3478:
3251:
3243:
3181:
2952:
2700:
2233:
2169:
1760:
1674:
1629:
1533:
1317:
102:
4250:
3554:
3544:
3534:
3468:
3417:
963:
953:
949:
945:
941:
917:
892:
888:
884:
880:
876:
872:
868:
858:
854:
850:
842:
4179:
4169:
4159:
4096:
3821:
3524:
1553:"T cell costimulation by TNFR superfamily (TNFRSF)4 and TNFRSF25 in the context of vaccination"
4189:
4174:
4091:
4056:
3801:
3306:
3240:
2225:
2161:
2131:
2086:
2051:
2008:
1972:
1943:
1908:
1871:
1842:
1813:
1752:
1709:
1666:
1621:
1582:
1525:
1484:
1435:
1383:
1309:
1263:
1123:
98:
50:
4116:
3291:
3842:
3771:
3766:
3654:
3311:
3140:
2943:
2816:
2649:
2550:
2542:
2534:
2526:
2153:
2121:
2111:
2076:
2041:
2033:
1998:
1964:
1933:
1900:
1863:
1834:
1803:
1793:
1742:
1699:
1658:
1613:
1572:
1564:
1515:
1474:
1466:
1425:
1417:
1373:
1365:
1301:
1253:
347:
278:
222:
177:
3750:
4220:
4197:
3742:
3659:
3422:
2566:
322:
2020:
Al-Lamki RS, Wang J, Thiru S, Pritchard NR, Bradley JA, Pober JS, Bradley JR (Aug 2003).
1896:
1789:
1738:
1654:
1297:
4081:
4071:
3998:
3615:
3605:
3529:
3361:
2467:
2046:
2021:
1987:"TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator"
1577:
1552:
1502:
Wolf D, Schreiber TH, Tryphonopoulos P, Li S, Tzakis AG, Ruiz P, Podack ER (Sep 2012).
1479:
1454:
1430:
1405:
1378:
1353:
2126:
2099:
2037:
2003:
1986:
1938:
1921:
1747:
1722:
1258:
1241:
650:
645:
640:
635:
630:
625:
620:
615:
610:
605:
600:
584:
579:
574:
569:
564:
559:
543:
538:
4294:
3649:
3432:
3351:
2919:
2713:
2188:
1808:
1773:
1369:
525:
1764:
1633:
1537:
1406:"Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation"
82:
4255:
4235:
4154:
4144:
4086:
4033:
3963:
3862:
3806:
3493:
3483:
3473:
3376:
3356:
3321:
3316:
3107:
2475:
2173:
1922:"Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)"
1678:
1321:
340:
119:
1772:
Screaton GR, Xu XN, Olsen AL, Cowper AE, Tan R, McMichael AJ, Bell JI (Apr 1997).
1904:
1662:
106:
4265:
4260:
4164:
4149:
4121:
4111:
4106:
4061:
4028:
4023:
4018:
4013:
4008:
3993:
3988:
3811:
3796:
3791:
3610:
3595:
3412:
2300:
2275:
1520:
1504:"Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival"
1503:
1227:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1209:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3209:
1778:
Proceedings of the
National Academy of Sciences of the United States of America
423:
4101:
4003:
3857:
3402:
1617:
1110:
adaptor molecule to stimulate caspase activation and regulate cell apoptosis.
239:
136:
86:
1568:
1339:"Entrez Gene: TNFRSF25 tumor necrosis factor receptor superfamily, member 25"
4275:
4270:
4051:
3498:
2590:
2582:
2574:
2157:
1688:"Normalization and subtraction: two approaches to facilitate gene discovery"
1135:
1082:
680:
483:
361:
306:
293:
205:
192:
94:
2165:
2135:
2116:
2090:
2081:
2064:
2055:
2012:
1976:
1968:
1947:
1867:
1838:
1798:
1625:
1586:
1529:
1488:
1439:
1387:
1912:
1875:
1846:
1817:
1756:
1713:
1670:
1313:
1267:
1046:
1041:
3503:
2630:
2622:
2614:
2598:
1470:
1030:
806:
17:
2999:
2995:
2742:
1704:
1687:
792:
747:
4076:
4066:
3711:
3707:
3703:
3699:
3695:
3691:
3135:
3130:
3125:
3120:
3097:
3037:
3033:
2773:
2406:
2194:
1421:
1305:
1139:
1127:
1014:
702:
1126:
expansion, which can reduce inflammation in experimental models of
3746:
3687:
3683:
3679:
3675:
3671:
3667:
3564:
3170:
2790:
2721:
2717:
2507:
2459:
2401:
2365:
2360:
2355:
2350:
2345:
2310:
2270:
2260:
1551:
Schreiber TH, Wolf D, Bodero M, Gonzalez L, Podack ER (Oct 2012).
1103:
1106:
adaptor molecule to stimulate NF-kappa B activity or through the
665:
661:
4131:
4043:
3980:
2558:
2499:
2491:
2483:
2394:
2305:
2285:
2280:
2265:
2256:
1143:
1107:
74:
3213:
2198:
1122:
Therapeutic agonists of TNFRSF25 can be used to stimulate
330:
3372:
Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
495:
1067:
tumor necrosis factor receptor superfamily member 25
4210:
4188:
4130:
4042:
3979:
3962:
3955:
3935:
3915:
3895:
3871:
3830:
3637:
3628:
3583:
3563:
3512:
3446:
3390:
3279:
3270:
3250:
3151:
3106:
3065:
2965:
2911:
2873:
2815:
2772:
2699:
2690:
2681:
2642:
2519:
2428:
2419:
2374:
2319:
2247:
2232:
1957:
1827:
977:
936:
906:
841:
454:
dentate gyrus of hippocampal formation granule cell
1183:
1181:
1179:
1162:
1160:
1158:
539:tumor necrosis factor-activated receptor activity
277:
176:
3464:Granulocyte macrophage colony-stimulating factor
631:tumor necrosis factor-mediated signaling pathway
1188:GRCm38: Ensembl release 89: ENSMUSG00000024793
3225:
2210:
1279:
1277:
8:
2100:"An unappreciated role for RNA surveillance"
1686:Bonaldo MF, Lennon G, Soares MB (Sep 1996).
1167:GRCh38: Ensembl release 89: ENSG00000215788
636:regulation of cell population proliferation
4231:Leukemia/leukocyte inhibitory factor (LIF)
3976:
3959:
3634:
3276:
3232:
3218:
3210:
2696:
2687:
2425:
2244:
2217:
2203:
2195:
2185:United States National Library of Medicine
2063:Wen L, Zhuang L, Luo X, Wei P (Oct 2003).
933:
838:
676:
521:
318:
217:
114:
4226:FMS-like tyrosine kinase 3 ligand (FLT3L)
3655:Interferon alpha (interferon alfa, IFN-α)
2125:
2115:
2098:Hillman RT, Green RE, Brenner SE (2005).
2080:
2045:
2002:
1937:
1807:
1797:
1746:
1703:
1576:
1519:
1478:
1429:
1377:
1257:
4248:Additional cytokine receptor modulators:
2183:This article incorporates text from the
1333:
1331:
1154:
616:cell surface receptor signaling pathway
4072:Cucurbitacin I (elatericin B, JSI-124)
1354:"On death receptor 3 and its ligands…"
1132:allogeneic solid organ transplantation
31:
3408:Granulocyte colony-stimulating factor
1410:The Journal of Clinical Investigation
580:integral component of plasma membrane
282:
243:
238:
181:
140:
135:
7:
3767:Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
3540:Macrophage colony-stimulating factor
4241:Thymic stromal lymphopoietin (TSLP)
2069:The Journal of Biological Chemistry
974:
903:
816:
797:
771:
752:
726:
707:
606:multicellular organism development
500:
418:
356:
335:
25:
2026:The American Journal of Pathology
1089:. Its only known TNFSF ligand is
1370:10.1111/j.1365-2567.2012.03606.x
266:
259:
253:
230:
165:
158:
152:
127:
3772:Interferon omega (IFN-ω, IFNW1)
601:regulation of apoptotic process
1079:tumor necrosis factor receptor
621:response to lipopolysaccharide
560:integral component of membrane
484:More reference expression data
372:right hemisphere of cerebellum
1:
2038:10.1016/S0002-9440(10)63670-X
2004:10.1016/S1074-7613(02)00283-2
1939:10.1016/S0014-5793(00)02219-5
1748:10.1016/S0960-9822(02)70791-4
1259:10.1016/S1074-7613(00)80244-7
251:
150:
1905:10.1126/science.283.5401.543
1663:10.1126/science.274.5289.990
4301:Genes on human chromosome 1
3616:Thrombopoietin (THPO, MGDF)
3382:Pegol sihematide (EPO-018B)
3302:Carbamylated erythropoietin
1521:10.1097/TP.0b013e318264d3ef
1081:superfamily which mediates
611:apoptotic signaling pathway
544:signaling receptor activity
4322:
404:mucosa of transverse colon
4165:Tofacitinib (tasocitinib)
4122:Tofacitinib (tasocitinib)
4029:Tofacitinib (tasocitinib)
1618:10.1080/08820530500511446
1606:Seminars in Ophthalmology
1223:"Mouse PubMed Reference:"
1205:"Human PubMed Reference:"
1045:
1040:
1036:
1029:
1013:
994:
981:
960:
929:
910:
865:
834:
823:
819:
804:
800:
791:
778:
774:
759:
755:
746:
733:
729:
714:
710:
701:
686:
679:
675:
659:
524:
520:
508:
503:
494:
481:
430:
421:
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
3843:Interferon gamma (IFN-γ)
1569:10.4049/jimmunol.1200597
3743:Interferon beta (IFN-β)
2158:10.1038/sj.gene.6364097
1007:Chr 4: 152.2 – 152.2 Mb
27:Protein found in humans
4221:Cardiotrophin 1 (CT-1)
3153:Enzyme-linked receptor
2117:10.1186/gb-2004-5-2-r8
2082:10.1074/jbc.M305833200
1969:10.1006/bbrc.2001.5761
1868:10.1006/geno.1998.5300
1839:10.1006/bbrc.1997.7948
1799:10.1073/pnas.94.9.4615
450:superior frontal gyrus
4218:Additional cytokines:
4145:Decernotinib (VX-509)
3782:Peginterferon alfa-2b
3777:Peginterferon alfa-2a
3297:Asialo erythropoietin
2975:Interleukin receptors
2883:Interleukin receptors
2825:Interleukin receptors
2782:Interleukin receptors
2709:Interleukin receptors
1557:Journal of Immunology
1075:cell surface receptor
1000:Chr 1: 6.46 – 6.47 Mb
626:inflammatory response
438:primary visual cortex
3733:Interferon alfacon-1
3362:Erythropoietin (EPO)
3025:Interferon receptors
1471:10.1128/JVI.01391-12
1352:Wang EC (Sep 2012).
1083:apoptotic signalling
565:extracellular region
245:Chromosome 4 (mouse)
143:Chromosome 1 (human)
107:TNFRSF25 - orthologs
4306:TNF receptor family
3880:See IL-28R (IFNLR)
3848:Interferon gamma 1b
3738:Interferon alpha-n3
1897:1999Sci...283..543J
1790:1997PNAS...94.4615S
1739:1996CBio....6.1669M
1655:1996Sci...274..990C
1459:Journal of Virology
1298:1996Natur.384..372K
1091:TNF-like protein 1A
646:signal transduction
4236:Oncostatin M (OSM)
3762:Interferon beta 1b
3757:Interferon beta 1a
3728:Interferon alfa n1
3723:Interferon alfa 2b
3718:Interferon alfa 2a
3552:Kinase inhibitors:
2234:Chemokine receptor
2226:Cytokine receptors
2187:, which is in the
2146:Genes and Immunity
1705:10.1101/gr.6.9.791
781:ENSMUSG00000024793
594:Biological process
553:Cellular component
532:Molecular function
396:right uterine tube
392:right frontal lobe
376:anterior pituitary
4288:
4287:
4284:
4283:
4206:
4205:
3973:
3891:
3890:
3624:
3623:
3367:Erythropoietin-Fc
3241:Cytokine receptor
3207:
3206:
3061:
3060:
2961:
2960:
2677:
2676:
2415:
2414:
1065:), also known as
1056:
1055:
1052:
1051:
1025:
1024:
990:
989:
971:
970:
925:
924:
900:
899:
830:
829:
813:
812:
787:
786:
768:
767:
742:
741:
723:
722:
671:
670:
651:apoptotic process
516:
515:
512:
511:
490:
489:
477:
476:
415:
414:
313:
312:
212:
211:
16:(Redirected from
4313:
3977:
3967:
3960:
3819:Decoy receptors:
3635:
3312:Darbepoetin alfa
3277:
3234:
3227:
3220:
3211:
2944:hormone receptor
2697:
2688:
2426:
2245:
2219:
2212:
2205:
2196:
2177:
2139:
2129:
2119:
2094:
2084:
2059:
2049:
2016:
2006:
1980:
1951:
1941:
1916:
1879:
1850:
1821:
1811:
1801:
1768:
1750:
1717:
1707:
1682:
1637:
1591:
1590:
1580:
1548:
1542:
1541:
1523:
1499:
1493:
1492:
1482:
1465:(19): 10606–20.
1450:
1444:
1443:
1433:
1422:10.1172/JCI42933
1401:
1392:
1391:
1381:
1349:
1343:
1342:
1335:
1326:
1325:
1306:10.1038/384372a0
1281:
1272:
1271:
1261:
1237:
1231:
1230:
1219:
1213:
1212:
1201:
1195:
1185:
1174:
1164:
1059:Death receptor 3
1038:
1037:
1009:
1002:
985:
975:
966:
934:
930:RefSeq (protein)
920:
904:
895:
839:
817:
798:
772:
753:
727:
708:
677:
522:
501:
486:
426:
424:Top expressed in
419:
364:
362:Top expressed in
357:
336:
319:
309:
296:
285:
270:
263:
257:
246:
234:
218:
208:
195:
184:
169:
162:
156:
145:
131:
115:
109:
60:
53:
32:
21:
4321:
4320:
4316:
4315:
4314:
4312:
4311:
4310:
4291:
4290:
4289:
4280:
4202:
4198:Deucravacitinib
4184:
4126:
4038:
3966:
3951:
3931:
3911:
3887:
3867:
3826:
3660:Interferon alfa
3620:
3579:
3559:
3508:
3442:
3438:Pegnartograstim
3423:Lipegfilgrastim
3386:
3332:Epoetin epsilon
3266:
3246:
3238:
3208:
3203:
3147:
3102:
3057:
2957:
2907:
2869:
2811:
2768:
2673:
2638:
2567:Osteoprotegerin
2515:
2411:
2370:
2315:
2236:
2228:
2223:
2180:
2142:
2097:
2075:(40): 39251–8.
2062:
2019:
1983:
1954:
1932:(2–3): 135–41.
1919:
1891:(5401): 543–6.
1882:
1853:
1824:
1771:
1733:(12): 1669–76.
1727:Current Biology
1720:
1692:Genome Research
1685:
1649:(5289): 990–2.
1640:
1603:
1599:
1597:Further reading
1594:
1550:
1549:
1545:
1508:Transplantation
1501:
1500:
1496:
1452:
1451:
1447:
1416:(10): 3629–40.
1403:
1402:
1395:
1351:
1350:
1346:
1337:
1336:
1329:
1292:(6607): 372–5.
1283:
1282:
1275:
1239:
1238:
1234:
1221:
1220:
1216:
1203:
1202:
1198:
1186:
1177:
1165:
1156:
1152:
1120:
1099:
1087:differentiation
1047:View/Edit Mouse
1042:View/Edit Human
1005:
998:
995:Location (UCSC)
983:
962:
956:
952:
948:
944:
940:
916:
912:
891:
887:
883:
879:
875:
871:
867:
861:
857:
853:
849:
845:
762:ENSG00000215788
655:
641:immune response
589:
575:plasma membrane
548:
482:
473:
468:
464:
462:muscle of thigh
460:
456:
452:
448:
444:
440:
436:
422:
411:
406:
402:
398:
394:
390:
386:
384:skin of abdomen
382:
378:
374:
360:
304:
291:
283:
273:
272:
271:
264:
244:
221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
28:
23:
22:
15:
12:
11:
5:
4319:
4317:
4309:
4308:
4303:
4293:
4292:
4286:
4285:
4282:
4281:
4279:
4278:
4273:
4268:
4263:
4258:
4253:
4244:
4243:
4238:
4233:
4228:
4223:
4214:
4212:
4208:
4207:
4204:
4203:
4201:
4200:
4194:
4192:
4186:
4185:
4183:
4182:
4177:
4172:
4167:
4162:
4157:
4152:
4147:
4142:
4140:Cercosporamide
4136:
4134:
4128:
4127:
4125:
4124:
4119:
4114:
4109:
4104:
4099:
4094:
4089:
4084:
4082:Deuruxolitinib
4079:
4074:
4069:
4064:
4059:
4054:
4048:
4046:
4040:
4039:
4037:
4036:
4031:
4026:
4021:
4016:
4011:
4006:
4001:
3999:Deuruxolitinib
3996:
3991:
3985:
3983:
3974:
3957:
3953:
3952:
3950:
3949:
3941:
3939:
3933:
3932:
3930:
3929:
3921:
3919:
3913:
3912:
3910:
3909:
3901:
3899:
3893:
3892:
3889:
3888:
3886:
3885:
3877:
3875:
3873:IFNLR (λ, III)
3869:
3868:
3866:
3865:
3860:
3851:
3850:
3845:
3836:
3834:
3828:
3827:
3825:
3824:
3815:
3814:
3809:
3804:
3799:
3794:
3785:
3784:
3779:
3774:
3769:
3764:
3759:
3754:
3740:
3735:
3730:
3725:
3720:
3715:
3657:
3652:
3643:
3641:
3639:IFNAR (α/β, I)
3632:
3626:
3625:
3622:
3621:
3619:
3618:
3613:
3608:
3606:Promegapoietin
3603:
3598:
3589:
3587:
3585:Thrombopoietin
3581:
3580:
3578:
3577:
3569:
3567:
3561:
3560:
3558:
3557:
3548:
3547:
3542:
3537:
3532:
3530:Interleukin-34
3527:
3518:
3516:
3510:
3509:
3507:
3506:
3501:
3496:
3487:
3486:
3481:
3476:
3471:
3466:
3461:
3452:
3450:
3444:
3443:
3441:
3440:
3435:
3430:
3425:
3420:
3415:
3410:
3405:
3396:
3394:
3388:
3387:
3385:
3384:
3379:
3374:
3369:
3364:
3359:
3354:
3349:
3344:
3339:
3334:
3329:
3324:
3319:
3314:
3309:
3304:
3299:
3294:
3285:
3283:
3281:Erythropoietin
3274:
3268:
3267:
3265:
3264:
3256:
3254:
3248:
3247:
3239:
3237:
3236:
3229:
3222:
3214:
3205:
3204:
3202:
3201:
3200:
3199:
3194:
3189:
3175:
3174:
3173:
3168:
3157:
3155:
3149:
3148:
3146:
3145:
3144:
3143:
3138:
3133:
3128:
3123:
3112:
3110:
3104:
3103:
3101:
3100:
3091:
3090:
3089:
3084:
3074:
3071:
3069:
3067:Ig superfamily
3063:
3062:
3059:
3058:
3056:
3055:
3054:
3053:
3040:
3022:
3021:
3020:
3015:
3002:
2971:
2969:
2963:
2962:
2959:
2958:
2956:
2955:
2950:
2940:
2939:
2938:
2937:
2935:Thrombopoietin
2932:
2927:
2915:
2913:
2909:
2908:
2906:
2905:
2904:
2903:
2898:
2879:
2877:
2871:
2870:
2868:
2867:
2862:
2857:
2852:
2851:
2850:
2841:
2832:
2821:
2819:
2813:
2812:
2810:
2809:
2804:
2803:
2802:
2793:
2778:
2776:
2770:
2769:
2767:
2766:
2765:
2764:
2759:
2754:
2745:
2728:
2705:
2703:
2694:
2685:
2679:
2678:
2675:
2674:
2672:
2671:
2663:
2655:
2646:
2644:
2640:
2639:
2637:
2636:
2628:
2620:
2612:
2604:
2596:
2588:
2580:
2572:
2564:
2556:
2548:
2540:
2532:
2523:
2521:
2517:
2516:
2514:
2513:
2505:
2497:
2489:
2481:
2473:
2465:
2457:
2449:
2441:
2432:
2430:
2423:
2417:
2416:
2413:
2412:
2410:
2409:
2404:
2399:
2398:
2397:
2389:
2388:
2387:
2378:
2376:
2372:
2371:
2369:
2368:
2363:
2358:
2353:
2348:
2343:
2342:
2341:
2336:
2325:
2323:
2317:
2316:
2314:
2313:
2308:
2303:
2298:
2293:
2288:
2283:
2278:
2273:
2268:
2263:
2253:
2251:
2242:
2230:
2229:
2224:
2222:
2221:
2214:
2207:
2199:
2179:
2178:
2140:
2104:Genome Biology
2095:
2060:
2017:
1981:
1952:
1917:
1880:
1851:
1822:
1769:
1718:
1698:(9): 791–806.
1683:
1638:
1600:
1598:
1595:
1593:
1592:
1543:
1494:
1445:
1393:
1344:
1327:
1273:
1232:
1214:
1196:
1175:
1153:
1151:
1148:
1119:
1116:
1098:
1095:
1054:
1053:
1050:
1049:
1044:
1034:
1033:
1027:
1026:
1023:
1022:
1020:
1018:
1011:
1010:
1003:
996:
992:
991:
988:
987:
979:
978:
972:
969:
968:
958:
957:
931:
927:
926:
923:
922:
908:
907:
901:
898:
897:
863:
862:
836:
832:
831:
828:
827:
821:
820:
814:
811:
810:
802:
801:
795:
789:
788:
785:
784:
776:
775:
769:
766:
765:
757:
756:
750:
744:
743:
740:
739:
731:
730:
724:
721:
720:
712:
711:
705:
699:
698:
693:
688:
684:
683:
673:
672:
669:
668:
657:
656:
654:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
603:
597:
595:
591:
590:
588:
587:
582:
577:
572:
567:
562:
556:
554:
550:
549:
547:
546:
541:
535:
533:
529:
528:
518:
517:
514:
513:
510:
509:
506:
505:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
428:
427:
416:
413:
412:
410:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4318:
4307:
4304:
4302:
4299:
4298:
4296:
4277:
4274:
4272:
4269:
4267:
4264:
4262:
4259:
4257:
4254:
4252:
4249:
4246:
4245:
4242:
4239:
4237:
4234:
4232:
4229:
4227:
4224:
4222:
4219:
4216:
4215:
4213:
4209:
4199:
4196:
4195:
4193:
4191:
4187:
4181:
4178:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4158:
4156:
4153:
4151:
4148:
4146:
4143:
4141:
4138:
4137:
4135:
4133:
4129:
4123:
4120:
4118:
4115:
4113:
4110:
4108:
4105:
4103:
4100:
4098:
4095:
4093:
4090:
4088:
4085:
4083:
4080:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4058:
4055:
4053:
4050:
4049:
4047:
4045:
4041:
4035:
4032:
4030:
4027:
4025:
4022:
4020:
4017:
4015:
4012:
4010:
4007:
4005:
4002:
4000:
3997:
3995:
3992:
3990:
3987:
3986:
3984:
3982:
3978:
3975:
3971:
3965:
3961:
3958:
3954:
3947:
3943:
3942:
3940:
3938:
3934:
3927:
3923:
3922:
3920:
3918:
3914:
3907:
3903:
3902:
3900:
3898:
3894:
3883:
3879:
3878:
3876:
3874:
3870:
3864:
3861:
3859:
3856:
3853:
3852:
3849:
3846:
3844:
3841:
3838:
3837:
3835:
3833:
3832:IFNGR (γ, II)
3829:
3823:
3820:
3817:
3816:
3813:
3810:
3808:
3805:
3803:
3800:
3798:
3795:
3793:
3790:
3787:
3786:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3752:
3748:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3713:
3709:
3705:
3701:
3697:
3693:
3689:
3685:
3681:
3677:
3673:
3669:
3665:
3661:
3658:
3656:
3653:
3651:
3650:Albinterferon
3648:
3645:
3644:
3642:
3640:
3636:
3633:
3631:
3627:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3591:
3590:
3588:
3586:
3582:
3575:
3571:
3570:
3568:
3566:
3562:
3556:
3553:
3550:
3549:
3546:
3543:
3541:
3538:
3536:
3533:
3531:
3528:
3526:
3523:
3520:
3519:
3517:
3515:
3511:
3505:
3502:
3500:
3497:
3495:
3492:
3489:
3488:
3485:
3482:
3480:
3477:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3457:
3454:
3453:
3451:
3449:
3448:GM-CSF (CSF2)
3445:
3439:
3436:
3434:
3433:Pegfilgrastim
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3414:
3411:
3409:
3406:
3404:
3401:
3398:
3397:
3395:
3393:
3389:
3383:
3380:
3378:
3375:
3373:
3370:
3368:
3365:
3363:
3360:
3358:
3355:
3353:
3352:Epoetin theta
3350:
3348:
3347:Epoetin omega
3345:
3343:
3342:Epoetin kappa
3340:
3338:
3337:Epoetin gamma
3335:
3333:
3330:
3328:
3327:Epoetin delta
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3295:
3293:
3290:
3287:
3286:
3284:
3282:
3278:
3275:
3273:
3269:
3262:
3258:
3257:
3255:
3253:
3249:
3245:
3242:
3235:
3230:
3228:
3223:
3221:
3216:
3215:
3212:
3198:
3195:
3193:
3190:
3188:
3185:
3184:
3183:
3179:
3176:
3172:
3169:
3167:
3164:
3163:
3162:
3159:
3158:
3156:
3154:
3150:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3118:
3117:
3114:
3113:
3111:
3109:
3105:
3099:
3095:
3092:
3088:
3085:
3083:
3080:
3079:
3078:
3075:
3073:
3072:
3070:
3068:
3064:
3052:
3048:
3044:
3041:
3039:
3035:
3031:
3028:
3027:
3026:
3023:
3019:
3016:
3014:
3010:
3006:
3003:
3001:
2997:
2993:
2989:
2985:
2981:
2978:
2977:
2976:
2973:
2972:
2970:
2968:
2964:
2954:
2951:
2949:
2945:
2942:
2941:
2936:
2933:
2931:
2928:
2926:
2923:
2922:
2921:
2920:CSF receptors
2917:
2916:
2914:
2910:
2902:
2899:
2897:
2893:
2889:
2886:
2885:
2884:
2881:
2880:
2878:
2876:
2872:
2866:
2863:
2861:
2858:
2856:
2853:
2849:
2845:
2842:
2840:
2836:
2833:
2831:
2828:
2827:
2826:
2823:
2822:
2820:
2818:
2814:
2808:
2805:
2801:
2797:
2794:
2792:
2788:
2785:
2784:
2783:
2780:
2779:
2777:
2775:
2771:
2763:
2760:
2758:
2755:
2753:
2749:
2746:
2744:
2740:
2736:
2732:
2729:
2727:
2723:
2719:
2715:
2712:
2711:
2710:
2707:
2706:
2704:
2702:
2698:
2695:
2693:
2689:
2686:
2684:
2680:
2670:
2667:
2664:
2662:
2659:
2656:
2654:
2651:
2648:
2647:
2645:
2641:
2635:
2632:
2629:
2627:
2624:
2621:
2619:
2616:
2613:
2611:
2608:
2605:
2603:
2600:
2597:
2595:
2592:
2589:
2587:
2584:
2581:
2579:
2576:
2573:
2571:
2568:
2565:
2563:
2560:
2557:
2555:
2552:
2549:
2547:
2544:
2541:
2539:
2536:
2533:
2531:
2528:
2525:
2524:
2522:
2518:
2512:
2509:
2506:
2504:
2501:
2498:
2496:
2493:
2490:
2488:
2485:
2482:
2480:
2477:
2474:
2472:
2469:
2466:
2464:
2461:
2458:
2456:
2453:
2450:
2448:
2445:
2442:
2440:
2437:
2434:
2433:
2431:
2427:
2424:
2422:
2418:
2408:
2405:
2403:
2400:
2396:
2393:
2392:
2390:
2386:
2383:
2382:
2380:
2379:
2377:
2373:
2367:
2364:
2362:
2359:
2357:
2354:
2352:
2349:
2347:
2344:
2340:
2337:
2335:
2332:
2331:
2330:
2327:
2326:
2324:
2322:
2318:
2312:
2309:
2307:
2304:
2302:
2299:
2297:
2294:
2292:
2289:
2287:
2284:
2282:
2279:
2277:
2274:
2272:
2269:
2267:
2264:
2262:
2258:
2255:
2254:
2252:
2250:
2246:
2243:
2240:
2235:
2231:
2227:
2220:
2215:
2213:
2208:
2206:
2201:
2200:
2197:
2193:
2192:
2190:
2189:public domain
2186:
2175:
2171:
2167:
2163:
2159:
2155:
2152:(6): 439–43.
2151:
2147:
2141:
2137:
2133:
2128:
2123:
2118:
2113:
2109:
2105:
2101:
2096:
2092:
2088:
2083:
2078:
2074:
2070:
2066:
2061:
2057:
2053:
2048:
2043:
2039:
2035:
2032:(2): 401–11.
2031:
2027:
2023:
2018:
2014:
2010:
2005:
2000:
1997:(3): 479–92.
1996:
1992:
1988:
1982:
1978:
1974:
1970:
1966:
1963:(2): 313–20.
1962:
1958:
1953:
1949:
1945:
1940:
1935:
1931:
1927:
1923:
1918:
1914:
1910:
1906:
1902:
1898:
1894:
1890:
1886:
1881:
1877:
1873:
1869:
1865:
1862:(3): 385–93.
1861:
1857:
1852:
1848:
1844:
1840:
1836:
1832:
1828:
1823:
1819:
1815:
1810:
1805:
1800:
1795:
1791:
1787:
1784:(9): 4615–9.
1783:
1779:
1775:
1770:
1766:
1762:
1758:
1754:
1749:
1744:
1740:
1736:
1732:
1728:
1724:
1719:
1715:
1711:
1706:
1701:
1697:
1693:
1689:
1684:
1680:
1676:
1672:
1668:
1664:
1660:
1656:
1652:
1648:
1644:
1639:
1635:
1631:
1627:
1623:
1619:
1615:
1611:
1607:
1602:
1601:
1596:
1588:
1584:
1579:
1574:
1570:
1566:
1563:(7): 3311–8.
1562:
1558:
1554:
1547:
1544:
1539:
1535:
1531:
1527:
1522:
1517:
1514:(6): 569–74.
1513:
1509:
1505:
1498:
1495:
1490:
1486:
1481:
1476:
1472:
1468:
1464:
1460:
1456:
1449:
1446:
1441:
1437:
1432:
1427:
1423:
1419:
1415:
1411:
1407:
1400:
1398:
1394:
1389:
1385:
1380:
1375:
1371:
1367:
1363:
1359:
1355:
1348:
1345:
1340:
1334:
1332:
1328:
1323:
1319:
1315:
1311:
1307:
1303:
1299:
1295:
1291:
1287:
1280:
1278:
1274:
1269:
1265:
1260:
1255:
1251:
1247:
1243:
1236:
1233:
1228:
1224:
1218:
1215:
1210:
1206:
1200:
1197:
1193:
1189:
1184:
1182:
1180:
1176:
1172:
1168:
1163:
1161:
1159:
1155:
1149:
1147:
1145:
1141:
1137:
1133:
1129:
1125:
1117:
1115:
1111:
1109:
1105:
1096:
1094:
1092:
1088:
1084:
1080:
1076:
1072:
1068:
1064:
1060:
1048:
1043:
1039:
1035:
1032:
1028:
1021:
1019:
1016:
1012:
1008:
1004:
1001:
997:
993:
986:
980:
976:
973:
967:
965:
959:
955:
951:
947:
943:
939:
935:
932:
928:
921:
919:
915:
909:
905:
902:
896:
894:
890:
886:
882:
878:
874:
870:
864:
860:
856:
852:
848:
844:
840:
837:
835:RefSeq (mRNA)
833:
826:
822:
818:
815:
809:
808:
803:
799:
796:
794:
790:
783:
782:
777:
773:
770:
764:
763:
758:
754:
751:
749:
745:
738:
737:
732:
728:
725:
719:
718:
713:
709:
706:
704:
700:
697:
694:
692:
689:
685:
682:
678:
674:
667:
663:
658:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
598:
596:
593:
592:
586:
583:
581:
578:
576:
573:
571:
568:
566:
563:
561:
558:
557:
555:
552:
551:
545:
542:
540:
537:
536:
534:
531:
530:
527:
526:Gene ontology
523:
519:
507:
502:
499:
497:
493:
485:
480:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
370:
367:
363:
358:
355:
354:
351:
349:
345:
343:
342:
338:
337:
334:
332:
328:
324:
320:
316:
308:
303:
299:
295:
290:
280:
276:
269:
262:
256:
249:
241:
237:
233:
228:
224:
219:
215:
207:
202:
198:
194:
189:
179:
175:
168:
161:
155:
148:
144:
138:
134:
130:
125:
121:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
30:
19:
4256:Lestaurtinib
4247:
4217:
4155:Ritlecitinib
4087:Lestaurtinib
4034:Upadacitinib
3863:Fontolizumab
3854:
3839:
3818:
3807:Rontalizumab
3788:
3646:
3601:Pegacaristim
3592:
3551:
3521:
3514:M-CSF (CSF1)
3494:Mavrilimumab
3490:
3484:Sargramostim
3474:Molgramostim
3459:Ecogramostim
3455:
3428:Nartograstim
3399:
3392:G-CSF (CSF3)
3377:Peginesatide
3357:Epoetin zeta
3322:Epoetin beta
3317:Epoetin alfa
3288:
3108:IL 17 family
2668:
2660:
2657:
2652:
2633:
2625:
2617:
2609:
2601:
2593:
2585:
2577:
2569:
2561:
2553:
2545:
2537:
2529:
2510:
2502:
2494:
2486:
2478:
2476:Fas receptor
2470:
2462:
2454:
2446:
2438:
2421:TNF receptor
2182:
2181:
2149:
2145:
2107:
2103:
2072:
2068:
2029:
2025:
1994:
1990:
1960:
1956:
1929:
1926:FEBS Letters
1925:
1888:
1884:
1859:
1855:
1833:(2): 376–9.
1830:
1826:
1781:
1777:
1730:
1726:
1695:
1691:
1646:
1642:
1612:(1): 49–58.
1609:
1605:
1560:
1556:
1546:
1511:
1507:
1497:
1462:
1458:
1448:
1413:
1409:
1364:(1): 114–6.
1361:
1357:
1347:
1289:
1285:
1252:(1): 79–88.
1249:
1245:
1235:
1226:
1217:
1208:
1199:
1121:
1118:Therapeutics
1112:
1100:
1070:
1066:
1062:
1058:
1057:
982:
961:
938:NP_001034753
914:NM_001291010
911:
866:
847:NM_001039664
824:
805:
779:
760:
734:
715:
695:
690:
346:
339:
305:152,204,576
292:152,200,391
66:External IDs
29:
4266:Quizartinib
4261:Midostaurin
4150:Peficitinib
4112:Ruxolitinib
4107:Peficitinib
4062:Baricitinib
4024:Ruxolitinib
4019:Peficitinib
4014:Oclacitinib
4009:Momelotinib
3994:Baricitinib
3989:Abrocitinib
3897:Interleukin
3855:Antibodies:
3812:Sifalimumab
3797:Faralimomab
3792:Anifrolumab
3789:Antibodies:
3611:Romiplostim
3596:Eltrombopag
3565:SCF (c-Kit)
3491:Antibodies:
3479:Regramostim
3413:Lenograstim
2594:(TNFRSF13C)
2586:(TNFRSF13B)
2578:(TNFRSF12A)
2570:(TNFRSF11B)
2562:(TNFRSF11A)
2554:(TNFRSF10D)
2546:(TNFRSF10C)
2538:(TNFRSF10B)
2530:(TNFRSF10A)
1134:and ocular
408:sural nerve
388:skin of leg
380:granulocyte
284:4|4 E2
44:Identifiers
4295:Categories
4251:Emfilermin
4102:Pacritinib
4004:Filgotinib
3970:inhibitors
3858:Emapalumab
3630:Interferon
3555:Agerafenib
3545:Mirimostim
3535:Lanimostim
3469:Milodistim
3418:Leridistim
3403:Filgrastim
3244:modulators
2669:(TNFRSF27)
2661:(TNFRSF25)
2653:(TNFRSF21)
2634:(TNFRSF19)
2626:(TNFRSF18)
2618:(TNFRSF17)
2610:(TNFRSF16)
2602:(TNFRSF14)
2487:(TNFRSF6B)
2447:(TNFRSF1B)
2439:(TNFRSF1A)
1358:Immunology
1194:, May 2017
1173:, May 2017
1150:References
446:blastocyst
350:(ortholog)
204:6,466,175
191:6,460,786
87:HomoloGene
4276:Sunitinib
4271:Sorafenib
4180:ZM-449829
4170:WHI-P 154
4160:TCS-21311
4097:NSC-33994
4052:Atiprimod
3840:Agonists:
3822:Bifarcept
3647:Agonists:
3593:Agonists:
3525:Cilmostim
3522:Agonists:
3499:Namilumab
3456:Agonists:
3400:Agonists:
3289:Agonists:
3252:Chemokine
2953:prolactin
2511:(TNFRSF9)
2503:(TNFRSF8)
2495:(TNFRSF7)
2479:(TNFRSF6)
2471:(TNFRSF5)
2463:(TNFRSF4)
2455:(TNFRSF3)
2110:(2): R8.
1136:keratitis
964:NP_683871
954:NP_683868
950:NP_683867
946:NP_683866
942:NP_003781
918:NM_033042
893:NM_148973
889:NM_148972
885:NM_148971
881:NM_148970
877:NM_148969
873:NM_148968
869:NM_148967
859:NM_148966
855:NM_148965
851:NM_003790
843:NM_148974
681:Orthologs
95:GeneCards
4175:ZM-39923
4092:NSC-7908
4057:AZD-1480
3948:instead.
3928:instead.
3908:instead.
3884:instead.
3802:MEDI-545
3576:instead.
3504:Otilimab
3307:CNTO-530
3263:instead.
3182:TGF-beta
2683:JAK-STAT
2631:TAJ/TROY
2166:15241467
2136:14759258
2091:12882979
2056:12875962
2013:11911831
1991:Immunity
1977:11606045
1948:11094155
1856:Genomics
1765:16088373
1634:41728328
1626:16517446
1587:22956587
1538:19548386
1530:22902792
1489:22811539
1440:20890040
1388:22612445
1246:Immunity
1190:–
1169:–
1097:Function
1093:(TL1A).
1073:), is a
1071:TNFRSF25
1031:Wikidata
660:Sources:
585:membrane
466:yolk sac
99:TNFRSF25
58:TNFRSF25
35:TNFRSF25
18:TNFRSF25
4117:SD-1008
3292:ARA-290
3178:Ser/Thr
3000:IL22RA2
2996:IL22RA1
2967:Type II
2896:IL12RB2
2892:IL12RB1
2875:IL12RB1
2774:β-chain
2743:IL13RA2
2739:IL13RA1
2701:γ-chain
2174:7357230
2047:1868232
1913:9915703
1893:Bibcode
1885:Science
1876:9615223
1847:9446802
1818:9114039
1786:Bibcode
1757:8994832
1735:Bibcode
1714:8889548
1679:2348299
1671:8875942
1651:Bibcode
1643:Science
1578:3449097
1480:3457251
1431:2947231
1379:3449252
1322:4283742
1314:8934525
1294:Bibcode
1268:9052839
1192:Ensembl
1171:Ensembl
1077:of the
793:UniProt
748:Ensembl
687:Species
666:QuickGO
570:cytosol
325:pattern
183:1p36.31
83:1934667
51:Aliases
4211:Others
4077:CYT387
4067:CHZ868
3956:Others
3712:IFNA21
3708:IFNA17
3704:IFNA16
3700:IFNA14
3696:IFNA13
3692:IFNA10
3197:family
3192:TGFBR2
3187:TGFBR1
3141:IL17RE
3136:IL17RD
3131:IL17RC
3126:IL17RB
3121:IL17RA
3098:IL18R1
3051:IFNGR2
3047:IFNGR1
3038:IFNAR2
3034:IFNAR1
3013:IL20RB
3009:IL20RA
2988:IL10RB
2984:IL10RA
2918:other
2848:IL27RA
2839:IL11RA
2807:GM-CSF
2692:Type I
2575:TweakR
2407:CMKLR1
2385:CX3CR1
2172:
2164:
2134:
2127:395752
2124:
2089:
2054:
2044:
2011:
1975:
1946:
1911:
1874:
1845:
1816:
1806:
1763:
1755:
1712:
1677:
1669:
1632:
1624:
1585:
1575:
1536:
1528:
1487:
1477:
1438:
1428:
1386:
1376:
1320:
1312:
1286:Nature
1266:
1140:CTLA-4
1128:asthma
1017:search
1015:PubMed
807:Q93038
703:Entrez
496:BioGPS
458:embryo
442:embryo
434:morula
400:spleen
75:603366
3751:IFNB3
3747:IFNB1
3688:IFNA8
3684:IFNA7
3680:IFNA6
3676:IFNA5
3672:IFNA4
3668:IFNA2
3664:IFNA1
3166:CSF1R
3094:IL18R
3087:IL1R2
3082:IL1R1
3018:IL28R
3005:IL20R
2992:IL22R
2980:IL10R
2930:G-CSF
2912:Other
2901:IL23R
2888:IL12R
2865:CNTFR
2830:IL6RA
2817:gp130
2800:IL5RA
2791:IL3RA
2762:IL21R
2752:IL7RA
2735:IL13R
2726:IL15R
2722:IL2RB
2718:IL2RA
2666:EDA2R
2643:21-27
2591:BAFFR
2520:11-20
2508:CD137
2460:CD134
2444:TNFR2
2436:TNFR1
2402:CCBP2
2381:CX3C
2375:Other
2366:CXCR7
2361:CXCR6
2356:CXCR5
2351:CXCR4
2346:CXCR3
2339:CXCR2
2334:CXCR1
2311:CCR10
2271:CCRL2
2261:CCRL1
2239:GPCRs
2170:S2CID
1809:20772
1761:S2CID
1675:S2CID
1630:S2CID
1534:S2CID
1318:S2CID
1104:TRADD
736:85030
696:Mouse
691:Human
662:Amigo
348:Mouse
341:Human
288:Start
223:Mouse
187:Start
120:Human
91:13202
4190:TYK2
4132:JAK3
4044:JAK2
3981:JAK1
3946:here
3944:See
3926:here
3924:See
3917:TGFβ
3906:here
3904:See
3882:here
3574:here
3572:See
3261:here
3259:See
3116:IL17
3030:-α/β
2860:LIFR
2855:OSMR
2796:IL5R
2787:IL3R
2757:IL9R
2748:IL7R
2731:IL4R
2714:IL2R
2623:GITR
2615:BCMA
2607:NGFR
2599:HVEM
2583:TACI
2559:RANK
2551:DcR2
2543:DcR1
2500:CD30
2492:CD27
2484:DcR3
2468:CD40
2452:LTBR
2429:1-10
2395:XCR1
2329:IL-8
2306:CCR9
2301:CCR8
2296:CCR7
2291:CCR6
2286:CCR5
2281:CCR4
2276:CCR3
2266:CCR2
2257:CCR1
2162:PMID
2132:PMID
2087:PMID
2052:PMID
2009:PMID
1973:PMID
1944:PMID
1909:PMID
1872:PMID
1843:PMID
1814:PMID
1753:PMID
1710:PMID
1667:PMID
1622:PMID
1583:PMID
1526:PMID
1485:PMID
1436:PMID
1384:PMID
1310:PMID
1264:PMID
1144:PD-1
1142:and
1124:Treg
1108:FADD
1085:and
717:8718
470:lens
331:Bgee
279:Band
240:Chr.
178:Band
137:Chr.
71:OMIM
3964:JAK
3937:TNF
3272:CSF
3171:KIT
3161:Tyr
3077:IL1
2925:EPO
2658:DR3
2650:DR6
2535:DR5
2527:DR4
2391:XC
2321:CXC
2154:doi
2122:PMC
2112:doi
2077:doi
2073:278
2042:PMC
2034:doi
2030:163
1999:doi
1965:doi
1961:288
1934:doi
1930:485
1901:doi
1889:283
1864:doi
1835:doi
1831:242
1804:PMC
1794:doi
1743:doi
1700:doi
1659:doi
1647:274
1614:doi
1573:PMC
1565:doi
1561:189
1516:doi
1475:PMC
1467:doi
1426:PMC
1418:doi
1414:120
1374:PMC
1366:doi
1362:137
1302:doi
1290:384
1254:doi
1063:DR3
984:n/a
825:n/a
504:n/a
301:End
200:End
103:OMA
79:MGI
4297::
3749:,
3710:,
3706:,
3702:,
3698:,
3694:,
3690:,
3686:,
3682:,
3678:,
3674:,
3670:,
3666:,
3180::
3096:/
3049:/
3043:-γ
3032:/
3011:/
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