308:
285:
182:
207:
566:
559:
1316:
increased IFN-gamma secretion as per CD137’s function as a costimulatory molecule. This enables the affected individual’s immune system to actively target and kill cancer cells that express CD137 on their cell surfaces. Currently, Utomilumab is the only mAb targeting CD137 on the market. Urelumab trials were temporarily halted due to risk of liver toxicity. Utomilumab trials resulted in the drug’s being cleared for therapeutic use.
314:
213:
1327:(PF-05082566) targets this receptor to stimulate a more intense immune system attack on cancers. It is a fully human IgG2 monoclonal antibody. It is in early clinical trials. As of June 2016, 5 clinical trials are active. In recent years, there has been a reignited interest in 4-1BB immunotherapy. Currently, there are several anti-4-1BB antibodies and recombinant proteins are in various stages of clinical trial.
1253:. This proliferation eventually leads to other immune cell responses and secretion of proinflammatory cytokines which result in exaggerated inflammatory responses that exacerbate atherosclerosis. Ongoing studies are researching CD137 as a biomarker for atherosclerosis as well as CD137 antagonists as potential therapeutics to reduce the symptoms associated with the condition.
1249:, and associated with cardiac inflammation, in the form of lesions in the walls of the atrial chambers and other vasculature. Treatments designed to target the CD137 molecules expressed on immune cell surfaces often lead to T cell proliferation as CD137 stimulation allows for the T cells to continue through the cell cycle. In this way, CD137 is often referred to as an
1261:
The mechanism connecting CD137 bidirectional signaling to the promotion of atherosclerosis is related to CD137 mediation of epithelial cell damage. When the CD137/CD137L complex interacts with endothelial cells, including those lining vascular structures, it induces the upregulation of molecules that
1315:
to target and kill cancer cells. Cancer cells upregulate cell surface CD137, however the reason behind this remains unclear. What is known is the fact that mAbs targeting CD137 are successful in fighting cancer as they can not only mark cancer cells, but they allow for CD8+ T cell activation and
61:
1278:. When they arrive, these cells initiate proinflammatory responses including cytokine secretion. In chronic cases, this results in excessive inflammation of the epithelial tissue, leading to cell damage and the formation of atherosclerotic inflammatory lesions.
1307:
CD137 is also involved in cancer having been found upregulated in cancerous cell lines. CD137/ligand stimulation has been found to lead to stronger anti-tumor responses due to cytotoxic T cell activation and is being examined as a possible anticancer therapy.
1153:
secretion. As a T cell co-stimulator, T cell receptor (TCR) and CD28 signaling causes expression of CD137 on T cell membranes. When CD137 then reacts with the CD137 ligand, it leads to CD137 upregulation. This is a form of self regulation or
2693:
Shulzhenko N, Morgun A, Chinellato AP, Rampim GF, Diniz RV, Almeida DR, Gerbase-DeLima M (March 2002). "CD27 but not CD70 and 4-1BB intragraft gene expression is a risk factor for acute cardiac allograft rejection in humans".
1210:
1228:
Cross-linking CD137 and active T cells can not only result in T cell proliferation via increased IL-2 secretion, but surviving cells also contribute to expanding immune system memory and augmenting T cell cytolytic activity.
2379:
Schwarz H, Arden K, Lotz M (June 1997). "CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies".
6109:
5468:
3702:
2280:
Schwarz H, Tuckwell J, Lotz M (December 1993). "A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family".
2076:
Schwarz H, Tuckwell J, Lotz M (December 1993). "A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family".
5893:
2841:
2411:"4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB"
1751:"4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB"
2243:
Alderson MR, Smith CA, Tough TW, Davis-Smith T, Armitage RJ, Falk B, et al. (September 1994). "Molecular and biological characterization of human 4-1BB and its ligand".
321:
220:
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6053:
5591:
3692:
6175:
6607:
4878:
2105:
Sica G, Chen L (2000). "Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy".
6235:
5886:
3672:
809:
790:
143:
5268:
4534:
2858:
2834:
2346:"Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB"
6578:
6567:
6543:
6033:
5839:
5557:
5553:
5536:
4265:
2452:
Jang IK, Lee ZH, Kim YJ, Kim SH, Kwon BS (January 1998). "Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B".
1714:
Jang IK, Lee ZH, Kim YJ, Kim SH, Kwon BS (January 1998). "Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B".
1263:
5922:
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5645:
5509:
4253:
4031:
6069:
5879:
5674:
5649:
5500:
4317:
4312:
4258:
4038:
2819:
2214:
Zhou Z, Kim S, Hurtado J, Lee ZH, Kim KK, Pollok KE, Kwon BS (February 1995). "Characterization of human homologue of 4-1BB and its ligand".
1421:
1218:
2625:"4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity"
1403:
6962:
6201:
5827:
5526:
5461:
3771:
3697:
2827:
1214:
2499:
2482:
2311:"ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival"
58:
5521:
4800:
4795:
4790:
4785:
3712:
1996:
307:
5933:
1032:
6887:
4765:
1025:
284:
5400:
5105:
5097:
4871:
4001:
5748:
5046:
4569:
4063:
3749:
1390:
1369:
1267:
2641:
2624:
6598:
6300:
5743:
5691:
5082:
4208:
3744:
2002:
1386:
206:
181:
4995:
4957:
4952:
4705:
4177:
4172:
4117:
3851:
3300:
1217:
expressed on APCs. The CD137 ligand is normally expressed at low levels, but can have increased expression in presence of
1365:
6902:
5000:
4399:
4122:
1092:
123:
320:
219:
5712:
5708:
4864:
3717:
1936:
1287:
5413:
313:
212:
6892:
6534:
5728:
5344:
4900:
4429:
2854:
1174:
114:, 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9, TNF receptor superfamily member 9
6493:
5963:
5704:
5628:
5327:
5113:
3295:
1627:
Söderström LÅ, Tarnawski L, Olofsson PS (May 2018). "CD137: A checkpoint regulator involved in atherosclerosis".
5858:
5822:
5353:
4479:
3374:
2725:"CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers"
854:
131:
2559:
Langstein J, Michel J, Schwarz H (November 1999). "CD137 induces proliferation and endomitosis in monocytes".
6246:
5942:
5777:
5755:
5679:
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5653:
5641:
5609:
5596:
5586:
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5549:
5505:
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5423:
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5387:
4982:
4443:
1974:
1128:
835:
5958:
6631:
5814:
5738:
5491:
5457:
5448:
5418:
5409:
5392:
4990:
4910:
3786:
3781:
3776:
3766:
3073:
3001:
2590:"A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction"
1246:
1088:
6443:
6438:
6389:
5516:
3130:
3048:
6028:
6043:
1213:. The CD137/ligand complex is also involved in regulation of the immune system. The CD137 ligand is a
6558:
6394:
6099:
5993:
5636:
5544:
5486:
5443:
5370:
4367:
4080:
2174:
2036:
1222:
1112:
195:
110:
6801:
6972:
6509:
6399:
6291:
6008:
6003:
5998:
5988:
5853:
5848:
5686:
4394:
4213:
2008:
1312:
1170:
1004:
1000:
949:
945:
6262:
6120:
6089:
1957:
Phase 1 Study of
Utomilumab (PF-05082566) In Combination with Rituximab in Patients with CD20+ NHL
6423:
6418:
6384:
6379:
6325:
6140:
5913:
5905:
5843:
5614:
5362:
4895:
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3535:
2807:
2754:
2327:
2310:
2268:
1955:
1798:
Makkouk A, Chester C, Kohrt HE (February 2016). "Rationale for anti-CD137 cancer immunotherapy".
155:
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6216:
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6130:
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1008:
979:
953:
924:
565:
6841:
6831:
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6758:
6483:
6186:
6967:
6851:
6836:
6753:
6718:
6463:
5968:
5902:
4887:
2799:
2746:
2711:
2681:
2646:
2611:
2576:
2547:
2504:
2469:
2440:
2397:
2367:
2332:
2297:
2260:
2231:
2202:
2149:
2114:
2093:
2064:
1915:
1886:"Unlocking the potential of agonist antibodies for treating cancer using antibody engineering"
1866:
1815:
1780:
1731:
1696:
1644:
1606:
1562:
1516:
1475:
1250:
1178:
1155:
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558:
103:
51:
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5953:
151:
6504:
6433:
6428:
6316:
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5802:
5605:
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5319:
5311:
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5204:
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4307:
4228:
3791:
2984:
2910:
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2703:
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2601:
2568:
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2529:
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2357:
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2223:
2192:
2182:
2139:
2085:
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2044:
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1856:
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1807:
1770:
1762:
1723:
1686:
1678:
1636:
1596:
1552:
1506:
1465:
1457:
1209:
CD137 and its ligand both induce signaling cascades upon interaction, a phenomenon known as
1136:
400:
331:
275:
230:
6412:
6882:
6859:
6404:
6321:
6084:
5228:
4634:
3170:
3165:
3088:
1640:
1242:
375:
2516:
Saoulli K, Lee SY, Cannons JL, Yeh WC, Santana A, Goldstein MD, et al. (June 1998).
2794:
2767:
2178:
2040:
1470:
1445:
6743:
6733:
6660:
6277:
6267:
6191:
6023:
5129:
4419:
3841:
3352:
3155:
2658:
Wilcox RA, Chapoval AI, Gorski KS, Otsuji M, Shin T, Flies DB, et al. (May 2002).
2542:
2517:
1910:
1885:
1861:
1834:
1691:
1666:
1143:
2707:
2606:
2589:
2435:
2410:
2197:
2162:
2059:
2024:
1775:
1750:
1095:, expressed on surfaces of leukocytes and non-immune cells. Its alternative names are
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
658:
653:
648:
643:
638:
633:
617:
612:
607:
6956:
6311:
6094:
6013:
5581:
5375:
4389:
3846:
2937:
2811:
2293:
2227:
2089:
1132:
594:
2758:
2518:"CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand"
2272:
135:
6917:
6897:
6816:
6806:
6748:
6695:
6625:
6524:
6468:
6155:
6145:
6135:
6038:
6018:
5983:
5978:
5769:
5137:
4745:
4053:
4043:
3574:
3540:
1336:
393:
172:
1901:
1142:
CD137 is a costimulatory molecule functioning to stimulate T cell proliferation,
159:
6927:
6922:
6826:
6811:
6783:
6773:
6768:
6723:
6690:
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6680:
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6655:
6650:
6473:
6458:
6453:
6272:
6257:
6074:
4962:
4937:
4755:
4404:
4182:
4157:
3856:
3478:
3404:
2878:
2676:
2659:
2344:
Loo DT, Chalupny NJ, Bajorath J, Shuford WW, Mittler RS, Aruffo A (March 1997).
1833:
Chu DT, Bac ND, Nguyen KH, Tien NL, Thanh VV, Nga VT, et al. (April 2019).
1426:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1408:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1198:
1182:
5871:
2784:
2167:
Proceedings of the
National Academy of Sciences of the United States of America
2029:
Proceedings of the
National Academy of Sciences of the United States of America
1811:
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476:
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3707:
3340:
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1324:
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1162:
production and T cell proliferation, among other signaling pathway responses.
292:
189:
139:
2572:
6937:
6932:
6713:
6160:
5252:
5244:
5236:
4524:
4519:
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2533:
2500:
10.1002/(SICI)1521-4141(199803)28:03<881::AID-IMMU881>3.0.CO;2-0
2362:
2345:
1682:
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1190:
754:
536:
414:
359:
346:
258:
245:
147:
2803:
2750:
2715:
2685:
2650:
2615:
2580:
2465:
2393:
2256:
2187:
2153:
2128:"Biological activities of reverse signal transduction through CD137 ligand"
2118:
2049:
1919:
1870:
1819:
1727:
1700:
1648:
1610:
1566:
1520:
1479:
2660:"Cutting edge: Expression of functional CD137 receptor by dendritic cells"
2551:
2508:
2473:
2444:
2401:
2371:
2336:
2301:
2264:
2235:
2206:
2097:
2068:
1784:
1735:
1123:
CD137 is only expressed on the cell surface after T cell activation. When
1072:
1067:
6165:
5292:
5284:
5276:
5260:
4830:
4730:
4544:
4529:
3732:
3727:
3635:
3325:
2483:"Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses"
2426:
1851:
1766:
1341:
1166:
1159:
1150:
1056:
899:
880:
2741:
2724:
2144:
2127:
5661:
5657:
5404:
4780:
4775:
4770:
4670:
4484:
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4301:
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4275:
4243:
4048:
3968:
3963:
3958:
3953:
3948:
3866:
3559:
3399:
3394:
3389:
3384:
3379:
2850:
866:
821:
17:
2309:
Schwarz H, Blanco FJ, von Kempis J, Valbracht J, Lotz M (April 1996).
80:
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3367:
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2642:
10.1002/1521-4141(200202)32:2<521::AID-IMMU521>3.0.CO;2-X
1186:
1147:
1124:
1040:
776:
1667:"Contributions of Costimulatory Molecule CD137 in Endothelial Cells"
1665:
Yuan W, Xu C, Li B, Xia H, Pan Y, Zhong W, et al. (June 2021).
2588:
Jang LK, Lee ZH, Kim HH, Hill JM, Kim JD, Kwon BS (December 2001).
6408:
6349:
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2723:
Pauly S, Broll K, Wittmann M, Giegerich G, Schwarz H (July 2002).
1835:"An Update on Anti-CD137 Antibodies in Immunotherapies for Cancer"
1291:
1937:"Pfizer cancer drug shows promise in combo with Merck's Keytruda"
1601:
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2883:
127:
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2823:
1963:. New Therapies in Hematology. Bologna, Italy. Study B1641001).
1165:
Other cells that express CD137 include both immune cells (i.e.
574:
4352:
2964:
2952:
2947:
2942:
2932:
2905:
2873:
1270:, on epithelial cells causes recruitment of immune cells like
1107:(ILA). It is of interest to immunologists as a co-stimulatory
1262:
promote inflammation and damage. For instance, increases in
1585:"CD137, implications in immunity and potential for therapy"
1541:"CD137, implications in immunity and potential for therapy"
1495:"CD137, implications in immunity and potential for therapy"
1158:. When CD137 interacts with its ligand, it leads to T cell
27:
Member of the tumor necrosis factor (TNF) receptor family
383:
6034:
Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
2766:
Singh R, Kim YH, Lee SJ, Eom HS, Choi BK (Feb 2024).
1884:
Jhajj HS, Lwo TS, Yao EL, Tessier PM (January 2023).
1444:
Singh R, Kim YH, Lee SJ, Eom HS, Choi BK (Feb 2024).
548:
2623:
Cooper D, Bansal-Pakala P, Croft M (February 2002).
710:
negative regulation of cell population proliferation
6872:
6850:
6792:
6704:
6641:
6624:
6617:
6597:
6577:
6557:
6533:
6492:
6299:
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6225:
6174:
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6052:
5941:
5932:
5912:
5813:
5768:
5727:
5627:
5573:
5535:
5477:
5434:
5361:
5352:
5343:
5304:
5181:
5090:
5081:
5036:
4981:
4909:
4894:
4658:
4452:
4201:
3885:
3608:
3268:
2866:
2454:
2382:
1716:
1097:
tumor necrosis factor receptor superfamily member 9
993:
972:
938:
917:
1382:
1380:
1378:
1361:
1359:
1357:
2107:Archivum Immunologiae et Therapiae Experimentalis
613:tumor necrosis factor-activated receptor activity
330:
229:
6126:Granulocyte macrophage colony-stimulating factor
2481:Kim YJ, Kim SH, Mantel P, Kwon BS (March 1998).
1931:
1929:
715:tumor necrosis factor-mediated signaling pathway
2163:"cDNA sequences of two inducible T-cell genes"
2025:"cDNA sequences of two inducible T-cell genes"
1387:GRCm38: Ensembl release 89: ENSMUSG00000028965
1219:pathogen associated molecular patterns (PAMPs)
5887:
4872:
2835:
8:
2772:Experimental & Molecular Medicine volume
2328:10.1182/blood.V87.7.2839.bloodjournal8772839
1450:Experimental & Molecular Medicine volume
1311:Current cancer immunotherapy treatments use
1266:, including vascular adhesion molecule-1 or
2768:"4-1BB immunotherapy: advances and hurdles"
1839:International Journal of Molecular Sciences
1446:"4-1BB immunotherapy: advances and hurdles"
1366:GRCh38: Ensembl release 89: ENSG00000049249
720:regulation of cell population proliferation
6893:Leukemia/leukocyte inhibitory factor (LIF)
6638:
6621:
6296:
5938:
5894:
5880:
5872:
5358:
5349:
5087:
4906:
4879:
4865:
4857:
2842:
2828:
2820:
1583:Thum E, Shao Z, Schwarz H (January 2009).
1539:Thum E, Shao Z, Schwarz H (January 2009).
1493:Thum E, Shao Z, Schwarz H (January 2009).
750:
590:
371:
270:
167:
69:
6888:FMS-like tyrosine kinase 3 ligand (FLT3L)
6317:Interferon alpha (interferon alfa, IFN-α)
2859:list of human clusters of differentiation
2793:
2783:
2740:
2675:
2640:
2605:
2541:
2498:
2434:
2361:
2326:
2196:
2186:
2143:
2058:
2048:
1909:
1860:
1850:
1774:
1690:
1671:Journal of the American Heart Association
1600:
1556:
1510:
1469:
1221:or proinflammatory immune responses like
1087:, a member of the tumor necrosis factor (
6910:Additional cytokine receptor modulators:
1353:
1111:molecule, and as a potential target in
6734:Cucurbitacin I (elatericin B, JSI-124)
29:
6070:Granulocyte colony-stimulating factor
2409:Arch RH, Thompson CB (January 1998).
1749:Arch RH, Thompson CB (January 1998).
1660:
1658:
1641:10.1016/j.atherosclerosis.2018.03.007
1578:
1576:
1534:
1532:
1530:
1439:
1437:
1435:
639:integral component of plasma membrane
335:
296:
291:
234:
193:
188:
7:
6429:Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
6202:Macrophage colony-stimulating factor
2522:The Journal of Experimental Medicine
1622:
1620:
6903:Thymic stromal lymphopoietin (TSLP)
2350:The Journal of Biological Chemistry
2161:Kwon BS, Weissman SM (March 1989).
2023:Kwon BS, Weissman SM (March 1989).
1215:type-II transmembrane glycoprotein
990:
969:
935:
914:
890:
871:
845:
826:
800:
781:
675:multicellular organism development
553:
471:
409:
388:
25:
1268:intracellular adhesion molecule-1
1211:bidirectional signal transduction
1175:follicular dendritic cells (FDCs)
1105:induced by lymphocyte activation
649:external side of plasma membrane
564:
557:
319:
312:
306:
283:
218:
211:
205:
180:
6434:Interferon omega (IFN-ω, IFNW1)
1205:Regulation of the immune system
1129:Antigen Presenting Cells (APCs)
680:regulation of apoptotic process
2629:European Journal of Immunology
2487:European Journal of Immunology
2415:Molecular and Cellular Biology
2245:European Journal of Immunology
1755:Molecular and Cellular Biology
685:response to lipopolysaccharide
634:integral component of membrane
575:More reference expression data
537:More reference expression data
1:
2708:10.1016/S0041-1345(02)02600-3
2607:10.1016/S1016-8478(23)25210-3
1975:"PF-05082566 clinical trials"
1181:) and non-immune cells (i.e.
1146:maturation, and promotion of
304:
203:
2729:Journal of Leukocyte Biology
2294:10.1016/0378-1119(93)90110-O
2228:10.1016/0165-2478(94)00227-I
2132:Journal of Leukocyte Biology
2090:10.1016/0378-1119(93)90110-O
1902:10.1016/j.molmed.2022.09.012
1890:Trends in Molecular Medicine
1313:monoclonal antibodies (mAbs)
1247:Cardiovascular Disease (CVD)
1131:, CD137 becomes embedded in
1093:type 1 transmembrane protein
6963:Genes on human chromosome 1
6278:Thrombopoietin (THPO, MGDF)
6044:Pegol sihematide (EPO-018B)
5964:Carbamylated erythropoietin
2855:clusters of differentiation
2696:Transplantation Proceedings
2677:10.4049/jimmunol.168.9.4262
725:apoptotic signaling pathway
618:signaling receptor activity
6989:
2785:10.1038/s12276-023-01136-4
2007:gene details page in the
1812:10.1016/j.ejca.2015.09.026
1800:European Journal of Cancer
1462:10.1038/s12276-023-01136-4
6827:Tofacitinib (tasocitinib)
6784:Tofacitinib (tasocitinib)
6691:Tofacitinib (tasocitinib)
1422:"Mouse PubMed Reference:"
1404:"Human PubMed Reference:"
1071:
1066:
1062:
1055:
1039:
1020:
997:
976:
965:
942:
921:
910:
897:
893:
878:
874:
865:
852:
848:
833:
829:
820:
807:
803:
788:
784:
775:
760:
753:
749:
733:
700:protein homotrimerization
593:
589:
572:
556:
547:
534:
483:
474:
421:
412:
382:
374:
370:
353:
340:
303:
282:
273:
269:
252:
239:
202:
179:
170:
166:
121:
118:
108:
101:
96:
77:
72:
55:
50:
45:
41:
37:
32:
6505:Interferon gamma (IFN-γ)
2573:10.1182/blood.V94.9.3161
2126:Schwarz H (March 2005).
1286:CD137 has been shown to
1245:is a disease, linked to
1091:) receptor family, is a
6405:Interferon beta (IFN-β)
2534:10.1084/jem.187.11.1849
2363:10.1074/jbc.272.10.6448
1683:10.1161/JAHA.120.020721
1589:Frontiers in Bioscience
1545:Frontiers in Bioscience
1499:Frontiers in Bioscience
1156:positive feedback cycle
6883:Cardiotrophin 1 (CT-1)
5815:Enzyme-linked receptor
2466:10.1006/bbrc.1997.8016
2394:10.1006/bbrc.1997.6870
2257:10.1002/eji.1830240943
2188:10.1073/pnas.86.6.1963
2050:10.1073/pnas.86.6.1963
1728:10.1006/bbrc.1997.8016
1033:Chr 4: 151 – 151.03 Mb
507:mesenteric lymph nodes
6880:Additional cytokines:
6807:Decernotinib (VX-509)
6444:Peginterferon alfa-2b
6439:Peginterferon alfa-2a
5959:Asialo erythropoietin
5637:Interleukin receptors
5545:Interleukin receptors
5487:Interleukin receptors
5444:Interleukin receptors
5371:Interleukin receptors
2664:Journal of Immunology
1026:Chr 1: 7.92 – 7.94 Mb
690:inflammatory response
6395:Interferon alfacon-1
6024:Erythropoietin (EPO)
5687:Interferon receptors
2427:10.1128/MCB.18.1.558
2001:genome location and
1954:Thall A (May 2016).
1852:10.3390/ijms20081822
1767:10.1128/MCB.18.1.558
1303:Cancer immunotherapy
1171:natural killer cells
1113:cancer immunotherapy
337:4 E2|4 81.52 cM
298:Chromosome 4 (mouse)
196:Chromosome 1 (human)
73:List of PDB id codes
46:Available structures
6542:See IL-28R (IFNLR)
6510:Interferon gamma 1b
6400:Interferon alpha-n3
2742:10.1189/jlb.72.1.35
2594:Molecules and Cells
2179:1989PNAS...86.1963K
2145:10.1189/jlb.0904558
2041:1989PNAS...86.1963K
2009:UCSC Genome Browser
1173:, dendritic cells,
654:extracellular space
511:islet of Langerhans
160:TNFRSF9 - orthologs
6898:Oncostatin M (OSM)
6424:Interferon beta 1b
6419:Interferon beta 1a
6390:Interferon alfa n1
6385:Interferon alfa 2b
6380:Interferon alfa 2a
6214:Kinase inhibitors:
4896:Chemokine receptor
4888:Cytokine receptors
2216:Immunology Letters
1979:clinicaltrials.gov
1264:adhesion molecules
1179:regulatory T cells
855:ENSMUSG00000028965
668:Biological process
627:Cellular component
601:Molecular function
425:buccal mucosa cell
6950:
6949:
6946:
6945:
6868:
6867:
6635:
6553:
6552:
6286:
6285:
6029:Erythropoietin-Fc
5903:Cytokine receptor
5869:
5868:
5723:
5722:
5623:
5622:
5339:
5338:
5077:
5076:
4854:
4853:
2528:(11): 1849–1862.
2356:(10): 6448–6456.
1595:(11): 4173–4188.
1551:(11): 4173–4188.
1505:(11): 4173–4188.
1257:Endothelial cells
1251:immune checkpoint
1199:endothelial cells
1127:are activated by
1109:immune checkpoint
1082:
1081:
1078:
1077:
1051:
1050:
1016:
1015:
987:
986:
961:
960:
932:
931:
906:
905:
887:
886:
861:
860:
842:
841:
816:
815:
797:
796:
745:
744:
705:apoptotic process
585:
584:
581:
580:
543:
542:
530:
529:
468:
467:
366:
365:
265:
264:
92:
91:
88:
87:
56:Ortholog search:
16:(Redirected from
6980:
6639:
6629:
6622:
6481:Decoy receptors:
6297:
5974:Darbepoetin alfa
5939:
5896:
5889:
5882:
5873:
5606:hormone receptor
5359:
5350:
5088:
4907:
4881:
4874:
4867:
4858:
2844:
2837:
2830:
2821:
2815:
2797:
2787:
2762:
2744:
2719:
2689:
2679:
2670:(9): 4262–4267.
2654:
2644:
2619:
2609:
2584:
2567:(9): 3161–3168.
2555:
2545:
2512:
2502:
2477:
2448:
2438:
2405:
2375:
2365:
2340:
2330:
2321:(7): 2839–2845.
2305:
2276:
2251:(9): 2219–2227.
2239:
2210:
2200:
2190:
2173:(6): 1963–1967.
2157:
2147:
2122:
2101:
2072:
2062:
2052:
2035:(6): 1963–1967.
1983:
1982:
1971:
1965:
1964:
1962:
1951:
1945:
1944:
1933:
1924:
1923:
1913:
1881:
1875:
1874:
1864:
1854:
1830:
1824:
1823:
1795:
1789:
1788:
1778:
1746:
1740:
1739:
1711:
1705:
1704:
1694:
1662:
1653:
1652:
1624:
1615:
1614:
1604:
1580:
1571:
1570:
1560:
1536:
1525:
1524:
1514:
1490:
1484:
1483:
1473:
1441:
1430:
1429:
1418:
1412:
1411:
1400:
1394:
1384:
1373:
1363:
1298:As a drug target
1064:
1063:
1035:
1028:
1011:
991:
982:
970:
966:RefSeq (protein)
956:
936:
927:
915:
891:
872:
846:
827:
801:
782:
751:
608:cytokine binding
591:
577:
568:
561:
554:
539:
479:
477:Top expressed in
472:
449:white blood cell
433:cartilage tissue
417:
415:Top expressed in
410:
389:
372:
362:
349:
338:
323:
316:
310:
299:
287:
271:
261:
248:
237:
222:
215:
209:
198:
184:
168:
162:
113:
106:
83:
70:
64:
43:
42:
30:
21:
6988:
6987:
6983:
6982:
6981:
6979:
6978:
6977:
6953:
6952:
6951:
6942:
6864:
6860:Deucravacitinib
6846:
6788:
6700:
6628:
6613:
6593:
6573:
6549:
6529:
6488:
6322:Interferon alfa
6282:
6241:
6221:
6170:
6104:
6100:Pegnartograstim
6085:Lipegfilgrastim
6048:
5994:Epoetin epsilon
5928:
5908:
5900:
5870:
5865:
5809:
5764:
5719:
5619:
5569:
5531:
5473:
5430:
5335:
5300:
5229:Osteoprotegerin
5177:
5073:
5032:
4977:
4898:
4890:
4885:
4855:
4850:
4654:
4448:
4197:
3881:
3604:
3264:
2862:
2848:
2818:
2765:
2722:
2692:
2657:
2622:
2587:
2558:
2515:
2480:
2451:
2408:
2378:
2343:
2308:
2279:
2242:
2213:
2160:
2125:
2104:
2075:
2022:
2018:
2016:Further reading
1992:
1987:
1986:
1973:
1972:
1968:
1960:
1953:
1952:
1948:
1935:
1934:
1927:
1883:
1882:
1878:
1832:
1831:
1827:
1797:
1796:
1792:
1748:
1747:
1743:
1713:
1712:
1708:
1677:(11): e020721.
1664:
1663:
1656:
1629:Atherosclerosis
1626:
1625:
1618:
1582:
1581:
1574:
1538:
1537:
1528:
1492:
1491:
1487:
1443:
1442:
1433:
1420:
1419:
1415:
1402:
1401:
1397:
1385:
1376:
1364:
1355:
1350:
1333:
1322:
1305:
1300:
1284:
1259:
1243:Atherosclerosis
1240:
1235:
1233:Atherosclerosis
1207:
1121:
1073:View/Edit Mouse
1068:View/Edit Human
1031:
1024:
1021:Location (UCSC)
1007:
1003:
999:
978:
952:
948:
944:
923:
836:ENSG00000049249
729:
695:immune response
663:
659:plasma membrane
622:
573:
563:
562:
535:
526:
521:
517:
513:
509:
505:
501:
497:
493:
489:
475:
464:
459:
455:
451:
447:
443:
439:
435:
431:
427:
413:
357:
344:
336:
326:
325:
324:
317:
297:
274:Gene location (
256:
243:
235:
225:
224:
223:
216:
194:
171:Gene location (
122:
109:
102:
79:
57:
28:
23:
22:
15:
12:
11:
5:
6986:
6984:
6976:
6975:
6970:
6965:
6955:
6954:
6948:
6947:
6944:
6943:
6941:
6940:
6935:
6930:
6925:
6920:
6915:
6906:
6905:
6900:
6895:
6890:
6885:
6876:
6874:
6870:
6869:
6866:
6865:
6863:
6862:
6856:
6854:
6848:
6847:
6845:
6844:
6839:
6834:
6829:
6824:
6819:
6814:
6809:
6804:
6802:Cercosporamide
6798:
6796:
6790:
6789:
6787:
6786:
6781:
6776:
6771:
6766:
6761:
6756:
6751:
6746:
6744:Deuruxolitinib
6741:
6736:
6731:
6726:
6721:
6716:
6710:
6708:
6702:
6701:
6699:
6698:
6693:
6688:
6683:
6678:
6673:
6668:
6663:
6661:Deuruxolitinib
6658:
6653:
6647:
6645:
6636:
6619:
6615:
6614:
6612:
6611:
6603:
6601:
6595:
6594:
6592:
6591:
6583:
6581:
6575:
6574:
6572:
6571:
6563:
6561:
6555:
6554:
6551:
6550:
6548:
6547:
6539:
6537:
6535:IFNLR (λ, III)
6531:
6530:
6528:
6527:
6522:
6513:
6512:
6507:
6498:
6496:
6490:
6489:
6487:
6486:
6477:
6476:
6471:
6466:
6461:
6456:
6447:
6446:
6441:
6436:
6431:
6426:
6421:
6416:
6402:
6397:
6392:
6387:
6382:
6377:
6319:
6314:
6305:
6303:
6301:IFNAR (α/β, I)
6294:
6288:
6287:
6284:
6283:
6281:
6280:
6275:
6270:
6268:Promegapoietin
6265:
6260:
6251:
6249:
6247:Thrombopoietin
6243:
6242:
6240:
6239:
6231:
6229:
6223:
6222:
6220:
6219:
6210:
6209:
6204:
6199:
6194:
6192:Interleukin-34
6189:
6180:
6178:
6172:
6171:
6169:
6168:
6163:
6158:
6149:
6148:
6143:
6138:
6133:
6128:
6123:
6114:
6112:
6106:
6105:
6103:
6102:
6097:
6092:
6087:
6082:
6077:
6072:
6067:
6058:
6056:
6050:
6049:
6047:
6046:
6041:
6036:
6031:
6026:
6021:
6016:
6011:
6006:
6001:
5996:
5991:
5986:
5981:
5976:
5971:
5966:
5961:
5956:
5947:
5945:
5943:Erythropoietin
5936:
5930:
5929:
5927:
5926:
5918:
5916:
5910:
5909:
5901:
5899:
5898:
5891:
5884:
5876:
5867:
5866:
5864:
5863:
5862:
5861:
5856:
5851:
5837:
5836:
5835:
5830:
5819:
5817:
5811:
5810:
5808:
5807:
5806:
5805:
5800:
5795:
5790:
5785:
5774:
5772:
5766:
5765:
5763:
5762:
5753:
5752:
5751:
5746:
5736:
5733:
5731:
5729:Ig superfamily
5725:
5724:
5721:
5720:
5718:
5717:
5716:
5715:
5702:
5684:
5683:
5682:
5677:
5664:
5633:
5631:
5625:
5624:
5621:
5620:
5618:
5617:
5612:
5602:
5601:
5600:
5599:
5597:Thrombopoietin
5594:
5589:
5577:
5575:
5571:
5570:
5568:
5567:
5566:
5565:
5560:
5541:
5539:
5533:
5532:
5530:
5529:
5524:
5519:
5514:
5513:
5512:
5503:
5494:
5483:
5481:
5475:
5474:
5472:
5471:
5466:
5465:
5464:
5455:
5440:
5438:
5432:
5431:
5429:
5428:
5427:
5426:
5421:
5416:
5407:
5390:
5367:
5365:
5356:
5347:
5341:
5340:
5337:
5336:
5334:
5333:
5325:
5317:
5308:
5306:
5302:
5301:
5299:
5298:
5290:
5282:
5274:
5266:
5258:
5250:
5242:
5234:
5226:
5218:
5210:
5202:
5194:
5185:
5183:
5179:
5178:
5176:
5175:
5167:
5159:
5151:
5143:
5135:
5127:
5119:
5111:
5103:
5094:
5092:
5085:
5079:
5078:
5075:
5074:
5072:
5071:
5066:
5061:
5060:
5059:
5051:
5050:
5049:
5040:
5038:
5034:
5033:
5031:
5030:
5025:
5020:
5015:
5010:
5005:
5004:
5003:
4998:
4987:
4985:
4979:
4978:
4976:
4975:
4970:
4965:
4960:
4955:
4950:
4945:
4940:
4935:
4930:
4925:
4915:
4913:
4904:
4892:
4891:
4886:
4884:
4883:
4876:
4869:
4861:
4852:
4851:
4849:
4848:
4843:
4838:
4833:
4828:
4823:
4818:
4813:
4808:
4803:
4798:
4793:
4788:
4783:
4778:
4773:
4768:
4763:
4758:
4753:
4748:
4743:
4738:
4733:
4728:
4723:
4718:
4713:
4708:
4703:
4698:
4693:
4688:
4683:
4678:
4673:
4668:
4662:
4660:
4656:
4655:
4653:
4652:
4647:
4642:
4637:
4632:
4627:
4622:
4617:
4612:
4607:
4602:
4597:
4592:
4587:
4582:
4577:
4572:
4567:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4492:
4487:
4482:
4477:
4472:
4467:
4462:
4456:
4454:
4450:
4449:
4447:
4446:
4441:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4387:
4386:
4385:
4380:
4370:
4365:
4360:
4355:
4350:
4345:
4340:
4335:
4330:
4325:
4320:
4315:
4310:
4305:
4299:
4290:
4285:
4284:
4283:
4278:
4268:
4263:
4262:
4261:
4256:
4246:
4241:
4236:
4231:
4226:
4221:
4216:
4211:
4205:
4203:
4199:
4198:
4196:
4195:
4190:
4185:
4180:
4175:
4170:
4165:
4160:
4155:
4150:
4145:
4140:
4135:
4130:
4125:
4120:
4115:
4110:
4109:
4108:
4103:
4093:
4088:
4083:
4078:
4077:
4076:
4071:
4066:
4056:
4051:
4046:
4041:
4036:
4035:
4034:
4029:
4019:
4014:
4009:
4004:
3999:
3994:
3989:
3988:
3987:
3982:
3972:
3966:
3961:
3956:
3951:
3942:
3937:
3936:
3935:
3930:
3925:
3915:
3910:
3905:
3900:
3895:
3889:
3887:
3883:
3882:
3880:
3879:
3874:
3869:
3864:
3859:
3854:
3849:
3844:
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3804:
3799:
3794:
3789:
3784:
3779:
3774:
3769:
3764:
3759:
3754:
3753:
3752:
3747:
3737:
3736:
3735:
3730:
3720:
3715:
3710:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3670:
3665:
3660:
3659:
3658:
3653:
3643:
3638:
3633:
3628:
3623:
3618:
3612:
3610:
3606:
3605:
3603:
3602:
3597:
3592:
3587:
3582:
3577:
3572:
3567:
3562:
3553:
3548:
3543:
3538:
3533:
3528:
3527:
3526:
3521:
3516:
3511:
3506:
3501:
3491:
3486:
3481:
3476:
3471:
3466:
3465:
3464:
3459:
3449:
3444:
3439:
3434:
3429:
3424:
3419:
3414:
3409:
3408:
3407:
3402:
3397:
3392:
3387:
3382:
3372:
3371:
3370:
3365:
3360:
3350:
3345:
3344:
3343:
3338:
3333:
3323:
3318:
3313:
3308:
3303:
3298:
3293:
3288:
3283:
3278:
3272:
3270:
3266:
3265:
3263:
3262:
3257:
3256:
3255:
3250:
3245:
3240:
3235:
3230:
3220:
3215:
3210:
3205:
3200:
3195:
3190:
3189:
3188:
3183:
3178:
3173:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3117:
3116:
3111:
3101:
3096:
3091:
3086:
3081:
3076:
3071:
3066:
3061:
3056:
3051:
3046:
3041:
3036:
3031:
3030:
3029:
3024:
3014:
3009:
3004:
2999:
2998:
2997:
2992:
2987:
2982:
2972:
2967:
2962:
2961:
2960:
2950:
2945:
2940:
2935:
2930:
2929:
2928:
2923:
2918:
2908:
2903:
2902:
2901:
2896:
2891:
2886:
2881:
2870:
2868:
2864:
2863:
2849:
2847:
2846:
2839:
2832:
2824:
2817:
2816:
2763:
2720:
2702:(2): 474–475.
2690:
2655:
2635:(2): 521–529.
2620:
2600:(3): 304–312.
2585:
2556:
2513:
2493:(3): 881–890.
2478:
2460:(3): 613–620.
2449:
2421:(1): 558–565.
2406:
2388:(3): 699–703.
2376:
2341:
2306:
2288:(2): 295–298.
2277:
2240:
2222:(1–2): 67–73.
2211:
2158:
2138:(3): 281–286.
2123:
2113:(5): 275–279.
2102:
2084:(2): 295–298.
2073:
2019:
2017:
2014:
2013:
2012:
1991:
1990:External links
1988:
1985:
1984:
1966:
1946:
1925:
1876:
1825:
1790:
1761:(1): 558–565.
1741:
1722:(3): 613–620.
1706:
1654:
1616:
1572:
1526:
1485:
1431:
1413:
1395:
1374:
1352:
1351:
1349:
1346:
1345:
1344:
1339:
1332:
1329:
1321:
1318:
1304:
1301:
1299:
1296:
1283:
1280:
1258:
1255:
1239:
1236:
1234:
1231:
1206:
1203:
1144:dendritic cell
1120:
1117:
1080:
1079:
1076:
1075:
1070:
1060:
1059:
1053:
1052:
1049:
1048:
1046:
1044:
1037:
1036:
1029:
1022:
1018:
1017:
1014:
1013:
995:
994:
988:
985:
984:
974:
973:
967:
963:
962:
959:
958:
940:
939:
933:
930:
929:
919:
918:
912:
908:
907:
904:
903:
895:
894:
888:
885:
884:
876:
875:
869:
863:
862:
859:
858:
850:
849:
843:
840:
839:
831:
830:
824:
818:
817:
814:
813:
805:
804:
798:
795:
794:
786:
785:
779:
773:
772:
767:
762:
758:
757:
747:
746:
743:
742:
731:
730:
728:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
671:
669:
665:
664:
662:
661:
656:
651:
646:
641:
636:
630:
628:
624:
623:
621:
620:
615:
610:
604:
602:
598:
597:
587:
586:
583:
582:
579:
578:
570:
569:
551:
545:
544:
541:
540:
532:
531:
528:
527:
525:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
481:
480:
469:
466:
465:
463:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
419:
418:
406:
405:
397:
386:
380:
379:
376:RNA expression
368:
367:
364:
363:
355:
351:
350:
342:
339:
334:
328:
327:
318:
311:
305:
301:
300:
295:
289:
288:
280:
279:
267:
266:
263:
262:
254:
250:
249:
241:
238:
233:
227:
226:
217:
210:
204:
200:
199:
192:
186:
185:
177:
176:
164:
163:
120:
116:
115:
107:
99:
98:
94:
93:
90:
89:
86:
85:
75:
74:
66:
65:
54:
48:
47:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6985:
6974:
6971:
6969:
6966:
6964:
6961:
6960:
6958:
6939:
6936:
6934:
6931:
6929:
6926:
6924:
6921:
6919:
6916:
6914:
6911:
6908:
6907:
6904:
6901:
6899:
6896:
6894:
6891:
6889:
6886:
6884:
6881:
6878:
6877:
6875:
6871:
6861:
6858:
6857:
6855:
6853:
6849:
6843:
6840:
6838:
6835:
6833:
6830:
6828:
6825:
6823:
6820:
6818:
6815:
6813:
6810:
6808:
6805:
6803:
6800:
6799:
6797:
6795:
6791:
6785:
6782:
6780:
6777:
6775:
6772:
6770:
6767:
6765:
6762:
6760:
6757:
6755:
6752:
6750:
6747:
6745:
6742:
6740:
6737:
6735:
6732:
6730:
6727:
6725:
6722:
6720:
6717:
6715:
6712:
6711:
6709:
6707:
6703:
6697:
6694:
6692:
6689:
6687:
6684:
6682:
6679:
6677:
6674:
6672:
6669:
6667:
6664:
6662:
6659:
6657:
6654:
6652:
6649:
6648:
6646:
6644:
6640:
6637:
6633:
6627:
6623:
6620:
6616:
6609:
6605:
6604:
6602:
6600:
6596:
6589:
6585:
6584:
6582:
6580:
6576:
6569:
6565:
6564:
6562:
6560:
6556:
6545:
6541:
6540:
6538:
6536:
6532:
6526:
6523:
6521:
6518:
6515:
6514:
6511:
6508:
6506:
6503:
6500:
6499:
6497:
6495:
6494:IFNGR (γ, II)
6491:
6485:
6482:
6479:
6478:
6475:
6472:
6470:
6467:
6465:
6462:
6460:
6457:
6455:
6452:
6449:
6448:
6445:
6442:
6440:
6437:
6435:
6432:
6430:
6427:
6425:
6422:
6420:
6417:
6414:
6410:
6406:
6403:
6401:
6398:
6396:
6393:
6391:
6388:
6386:
6383:
6381:
6378:
6375:
6371:
6367:
6363:
6359:
6355:
6351:
6347:
6343:
6339:
6335:
6331:
6327:
6323:
6320:
6318:
6315:
6313:
6312:Albinterferon
6310:
6307:
6306:
6304:
6302:
6298:
6295:
6293:
6289:
6279:
6276:
6274:
6271:
6269:
6266:
6264:
6261:
6259:
6256:
6253:
6252:
6250:
6248:
6244:
6237:
6233:
6232:
6230:
6228:
6224:
6218:
6215:
6212:
6211:
6208:
6205:
6203:
6200:
6198:
6195:
6193:
6190:
6188:
6185:
6182:
6181:
6179:
6177:
6173:
6167:
6164:
6162:
6159:
6157:
6154:
6151:
6150:
6147:
6144:
6142:
6139:
6137:
6134:
6132:
6129:
6127:
6124:
6122:
6119:
6116:
6115:
6113:
6111:
6110:GM-CSF (CSF2)
6107:
6101:
6098:
6096:
6095:Pegfilgrastim
6093:
6091:
6088:
6086:
6083:
6081:
6078:
6076:
6073:
6071:
6068:
6066:
6063:
6060:
6059:
6057:
6055:
6051:
6045:
6042:
6040:
6037:
6035:
6032:
6030:
6027:
6025:
6022:
6020:
6017:
6015:
6014:Epoetin theta
6012:
6010:
6009:Epoetin omega
6007:
6005:
6004:Epoetin kappa
6002:
6000:
5999:Epoetin gamma
5997:
5995:
5992:
5990:
5989:Epoetin delta
5987:
5985:
5982:
5980:
5977:
5975:
5972:
5970:
5967:
5965:
5962:
5960:
5957:
5955:
5952:
5949:
5948:
5946:
5944:
5940:
5937:
5935:
5931:
5924:
5920:
5919:
5917:
5915:
5911:
5907:
5904:
5897:
5892:
5890:
5885:
5883:
5878:
5877:
5874:
5860:
5857:
5855:
5852:
5850:
5847:
5846:
5845:
5841:
5838:
5834:
5831:
5829:
5826:
5825:
5824:
5821:
5820:
5818:
5816:
5812:
5804:
5801:
5799:
5796:
5794:
5791:
5789:
5786:
5784:
5781:
5780:
5779:
5776:
5775:
5773:
5771:
5767:
5761:
5757:
5754:
5750:
5747:
5745:
5742:
5741:
5740:
5737:
5735:
5734:
5732:
5730:
5726:
5714:
5710:
5706:
5703:
5701:
5697:
5693:
5690:
5689:
5688:
5685:
5681:
5678:
5676:
5672:
5668:
5665:
5663:
5659:
5655:
5651:
5647:
5643:
5640:
5639:
5638:
5635:
5634:
5632:
5630:
5626:
5616:
5613:
5611:
5607:
5604:
5603:
5598:
5595:
5593:
5590:
5588:
5585:
5584:
5583:
5582:CSF receptors
5579:
5578:
5576:
5572:
5564:
5561:
5559:
5555:
5551:
5548:
5547:
5546:
5543:
5542:
5540:
5538:
5534:
5528:
5525:
5523:
5520:
5518:
5515:
5511:
5507:
5504:
5502:
5498:
5495:
5493:
5490:
5489:
5488:
5485:
5484:
5482:
5480:
5476:
5470:
5467:
5463:
5459:
5456:
5454:
5450:
5447:
5446:
5445:
5442:
5441:
5439:
5437:
5433:
5425:
5422:
5420:
5417:
5415:
5411:
5408:
5406:
5402:
5398:
5394:
5391:
5389:
5385:
5381:
5377:
5374:
5373:
5372:
5369:
5368:
5366:
5364:
5360:
5357:
5355:
5351:
5348:
5346:
5342:
5332:
5329:
5326:
5324:
5321:
5318:
5316:
5313:
5310:
5309:
5307:
5303:
5297:
5294:
5291:
5289:
5286:
5283:
5281:
5278:
5275:
5273:
5270:
5267:
5265:
5262:
5259:
5257:
5254:
5251:
5249:
5246:
5243:
5241:
5238:
5235:
5233:
5230:
5227:
5225:
5222:
5219:
5217:
5214:
5211:
5209:
5206:
5203:
5201:
5198:
5195:
5193:
5190:
5187:
5186:
5184:
5180:
5174:
5171:
5168:
5166:
5163:
5160:
5158:
5155:
5152:
5150:
5147:
5144:
5142:
5139:
5136:
5134:
5131:
5128:
5126:
5123:
5120:
5118:
5115:
5112:
5110:
5107:
5104:
5102:
5099:
5096:
5095:
5093:
5089:
5086:
5084:
5080:
5070:
5067:
5065:
5062:
5058:
5055:
5054:
5052:
5048:
5045:
5044:
5042:
5041:
5039:
5035:
5029:
5026:
5024:
5021:
5019:
5016:
5014:
5011:
5009:
5006:
5002:
4999:
4997:
4994:
4993:
4992:
4989:
4988:
4986:
4984:
4980:
4974:
4971:
4969:
4966:
4964:
4961:
4959:
4956:
4954:
4951:
4949:
4946:
4944:
4941:
4939:
4936:
4934:
4931:
4929:
4926:
4924:
4920:
4917:
4916:
4914:
4912:
4908:
4905:
4902:
4897:
4893:
4889:
4882:
4877:
4875:
4870:
4868:
4863:
4862:
4859:
4847:
4844:
4842:
4839:
4837:
4834:
4832:
4829:
4827:
4824:
4822:
4819:
4817:
4814:
4812:
4809:
4807:
4804:
4802:
4799:
4797:
4794:
4792:
4789:
4787:
4784:
4782:
4779:
4777:
4774:
4772:
4769:
4767:
4764:
4762:
4759:
4757:
4754:
4752:
4749:
4747:
4744:
4742:
4739:
4737:
4734:
4732:
4729:
4727:
4724:
4722:
4719:
4717:
4714:
4712:
4709:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:
4677:
4674:
4672:
4669:
4667:
4664:
4663:
4661:
4657:
4651:
4648:
4646:
4643:
4641:
4638:
4636:
4633:
4631:
4628:
4626:
4623:
4621:
4618:
4616:
4613:
4611:
4608:
4606:
4603:
4601:
4598:
4596:
4593:
4591:
4588:
4586:
4583:
4581:
4578:
4576:
4573:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4457:
4455:
4451:
4445:
4442:
4440:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4384:
4381:
4379:
4376:
4375:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4356:
4354:
4351:
4349:
4346:
4344:
4341:
4339:
4336:
4334:
4331:
4329:
4326:
4324:
4321:
4319:
4316:
4314:
4311:
4309:
4306:
4303:
4300:
4298:
4294:
4291:
4289:
4286:
4282:
4279:
4277:
4274:
4273:
4272:
4269:
4267:
4264:
4260:
4257:
4255:
4252:
4251:
4250:
4247:
4245:
4242:
4240:
4237:
4235:
4232:
4230:
4227:
4225:
4222:
4220:
4217:
4215:
4212:
4210:
4207:
4206:
4204:
4200:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4151:
4149:
4146:
4144:
4141:
4139:
4136:
4134:
4131:
4129:
4126:
4124:
4121:
4119:
4116:
4114:
4111:
4107:
4104:
4102:
4099:
4098:
4097:
4094:
4092:
4089:
4087:
4084:
4082:
4079:
4075:
4072:
4070:
4067:
4065:
4062:
4061:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4040:
4037:
4033:
4030:
4028:
4025:
4024:
4023:
4020:
4018:
4015:
4013:
4010:
4008:
4005:
4003:
4000:
3998:
3995:
3993:
3990:
3986:
3983:
3981:
3978:
3977:
3976:
3973:
3970:
3967:
3965:
3962:
3960:
3957:
3955:
3952:
3950:
3946:
3943:
3941:
3938:
3934:
3931:
3929:
3926:
3924:
3921:
3920:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3890:
3888:
3884:
3878:
3875:
3873:
3870:
3868:
3865:
3863:
3860:
3858:
3855:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3805:
3803:
3800:
3798:
3795:
3793:
3790:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3751:
3748:
3746:
3743:
3742:
3741:
3738:
3734:
3731:
3729:
3726:
3725:
3724:
3721:
3719:
3716:
3714:
3711:
3709:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3669:
3666:
3664:
3661:
3657:
3654:
3652:
3649:
3648:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3613:
3611:
3607:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3578:
3576:
3573:
3571:
3568:
3566:
3563:
3561:
3557:
3554:
3552:
3549:
3547:
3544:
3542:
3539:
3537:
3534:
3532:
3529:
3525:
3522:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3496:
3495:
3492:
3490:
3487:
3485:
3482:
3480:
3477:
3475:
3472:
3470:
3467:
3463:
3460:
3458:
3455:
3454:
3453:
3450:
3448:
3445:
3443:
3440:
3438:
3435:
3433:
3430:
3428:
3425:
3423:
3420:
3418:
3415:
3413:
3410:
3406:
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3377:
3376:
3373:
3369:
3366:
3364:
3361:
3359:
3356:
3355:
3354:
3351:
3349:
3346:
3342:
3339:
3337:
3334:
3332:
3329:
3328:
3327:
3324:
3322:
3319:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3297:
3294:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3273:
3271:
3267:
3261:
3258:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3225:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3204:
3201:
3199:
3196:
3194:
3191:
3187:
3184:
3182:
3179:
3177:
3174:
3172:
3169:
3168:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3115:
3112:
3110:
3107:
3106:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3085:
3082:
3080:
3077:
3075:
3072:
3070:
3067:
3065:
3062:
3060:
3057:
3055:
3052:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3028:
3025:
3023:
3020:
3019:
3018:
3015:
3013:
3010:
3008:
3005:
3003:
3000:
2996:
2993:
2991:
2988:
2986:
2983:
2981:
2978:
2977:
2976:
2973:
2971:
2968:
2966:
2963:
2959:
2956:
2955:
2954:
2951:
2949:
2946:
2944:
2941:
2939:
2936:
2934:
2931:
2927:
2924:
2922:
2919:
2917:
2914:
2913:
2912:
2909:
2907:
2904:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2876:
2875:
2872:
2871:
2869:
2865:
2860:
2856:
2852:
2845:
2840:
2838:
2833:
2831:
2826:
2825:
2822:
2813:
2809:
2805:
2801:
2796:
2791:
2786:
2781:
2777:
2773:
2769:
2764:
2760:
2756:
2752:
2748:
2743:
2738:
2734:
2730:
2726:
2721:
2717:
2713:
2709:
2705:
2701:
2697:
2691:
2687:
2683:
2678:
2673:
2669:
2665:
2661:
2656:
2652:
2648:
2643:
2638:
2634:
2630:
2626:
2621:
2617:
2613:
2608:
2603:
2599:
2595:
2591:
2586:
2582:
2578:
2574:
2570:
2566:
2562:
2557:
2553:
2549:
2544:
2539:
2535:
2531:
2527:
2523:
2519:
2514:
2510:
2506:
2501:
2496:
2492:
2488:
2484:
2479:
2475:
2471:
2467:
2463:
2459:
2455:
2450:
2446:
2442:
2437:
2432:
2428:
2424:
2420:
2416:
2412:
2407:
2403:
2399:
2395:
2391:
2387:
2383:
2377:
2373:
2369:
2364:
2359:
2355:
2351:
2347:
2342:
2338:
2334:
2329:
2324:
2320:
2316:
2312:
2307:
2303:
2299:
2295:
2291:
2287:
2283:
2278:
2274:
2270:
2266:
2262:
2258:
2254:
2250:
2246:
2241:
2237:
2233:
2229:
2225:
2221:
2217:
2212:
2208:
2204:
2199:
2194:
2189:
2184:
2180:
2176:
2172:
2168:
2164:
2159:
2155:
2151:
2146:
2141:
2137:
2133:
2129:
2124:
2120:
2116:
2112:
2108:
2103:
2099:
2095:
2091:
2087:
2083:
2079:
2074:
2070:
2066:
2061:
2056:
2051:
2046:
2042:
2038:
2034:
2030:
2026:
2021:
2020:
2015:
2010:
2006:
2005:
2000:
1999:
1994:
1993:
1989:
1980:
1976:
1970:
1967:
1959:
1958:
1950:
1947:
1942:
1938:
1932:
1930:
1926:
1921:
1917:
1912:
1907:
1903:
1899:
1895:
1891:
1887:
1880:
1877:
1872:
1868:
1863:
1858:
1853:
1848:
1844:
1840:
1836:
1829:
1826:
1821:
1817:
1813:
1809:
1805:
1801:
1794:
1791:
1786:
1782:
1777:
1772:
1768:
1764:
1760:
1756:
1752:
1745:
1742:
1737:
1733:
1729:
1725:
1721:
1717:
1710:
1707:
1702:
1698:
1693:
1688:
1684:
1680:
1676:
1672:
1668:
1661:
1659:
1655:
1650:
1646:
1642:
1638:
1634:
1630:
1623:
1621:
1617:
1612:
1608:
1603:
1598:
1594:
1590:
1586:
1579:
1577:
1573:
1568:
1564:
1559:
1554:
1550:
1546:
1542:
1535:
1533:
1531:
1527:
1522:
1518:
1513:
1508:
1504:
1500:
1496:
1489:
1486:
1481:
1477:
1472:
1467:
1463:
1459:
1455:
1451:
1447:
1440:
1438:
1436:
1432:
1427:
1423:
1417:
1414:
1409:
1405:
1399:
1396:
1392:
1388:
1383:
1381:
1379:
1375:
1371:
1367:
1362:
1360:
1358:
1354:
1347:
1343:
1340:
1338:
1335:
1334:
1330:
1328:
1326:
1319:
1317:
1314:
1309:
1302:
1297:
1295:
1293:
1289:
1281:
1279:
1277:
1273:
1269:
1265:
1256:
1254:
1252:
1248:
1244:
1237:
1232:
1230:
1226:
1224:
1220:
1216:
1212:
1204:
1202:
1200:
1196:
1192:
1188:
1184:
1180:
1176:
1172:
1168:
1163:
1161:
1157:
1152:
1149:
1145:
1140:
1138:
1134:
1130:
1126:
1118:
1116:
1114:
1110:
1106:
1102:
1098:
1094:
1090:
1086:
1074:
1069:
1065:
1061:
1058:
1054:
1047:
1045:
1042:
1038:
1034:
1030:
1027:
1023:
1019:
1012:
1010:
1006:
1002:
996:
992:
989:
983:
981:
975:
971:
968:
964:
957:
955:
951:
947:
941:
937:
934:
928:
926:
920:
916:
913:
911:RefSeq (mRNA)
909:
902:
901:
896:
892:
889:
883:
882:
877:
873:
870:
868:
864:
857:
856:
851:
847:
844:
838:
837:
832:
828:
825:
823:
819:
812:
811:
806:
802:
799:
793:
792:
787:
783:
780:
778:
774:
771:
768:
766:
763:
759:
756:
752:
748:
741:
737:
732:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
672:
670:
667:
666:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
631:
629:
626:
625:
619:
616:
614:
611:
609:
606:
605:
603:
600:
599:
596:
595:Gene ontology
592:
588:
576:
571:
567:
560:
555:
552:
550:
546:
538:
533:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
485:
482:
478:
473:
470:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
423:
420:
416:
411:
408:
407:
404:
402:
398:
396:
395:
391:
390:
387:
385:
381:
377:
373:
369:
361:
356:
352:
348:
343:
333:
329:
322:
315:
309:
302:
294:
290:
286:
281:
277:
272:
268:
260:
255:
251:
247:
242:
232:
228:
221:
214:
208:
201:
197:
191:
187:
183:
178:
174:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
117:
112:
105:
100:
95:
84:
82:
76:
71:
68:
67:
63:
60:
53:
49:
44:
40:
36:
31:
19:
6918:Lestaurtinib
6909:
6879:
6817:Ritlecitinib
6749:Lestaurtinib
6696:Upadacitinib
6525:Fontolizumab
6516:
6501:
6480:
6469:Rontalizumab
6450:
6308:
6263:Pegacaristim
6254:
6213:
6183:
6176:M-CSF (CSF1)
6156:Mavrilimumab
6152:
6146:Sargramostim
6136:Molgramostim
6121:Ecogramostim
6117:
6090:Nartograstim
6061:
6054:G-CSF (CSF3)
6039:Peginesatide
6019:Epoetin zeta
5984:Epoetin beta
5979:Epoetin alfa
5950:
5770:IL 17 family
5330:
5322:
5314:
5295:
5287:
5279:
5271:
5263:
5255:
5247:
5239:
5231:
5223:
5215:
5207:
5199:
5191:
5172:
5169:
5164:
5156:
5148:
5140:
5138:Fas receptor
5132:
5124:
5116:
5108:
5100:
5083:TNF receptor
4372:
4292:
4270:
4248:
4095:
4058:
4021:
3974:
3944:
3917:
3826:
3739:
3645:
3493:
3222:
2974:
2778:(1): 32–39.
2775:
2771:
2735:(1): 35–42.
2732:
2728:
2699:
2695:
2667:
2663:
2632:
2628:
2597:
2593:
2564:
2560:
2525:
2521:
2490:
2486:
2457:
2453:
2418:
2414:
2385:
2381:
2353:
2349:
2318:
2314:
2285:
2281:
2248:
2244:
2219:
2215:
2170:
2166:
2135:
2131:
2110:
2106:
2081:
2077:
2032:
2028:
2003:
1997:
1978:
1969:
1956:
1949:
1940:
1896:(1): 48–60.
1893:
1889:
1879:
1842:
1838:
1828:
1803:
1799:
1793:
1758:
1754:
1744:
1719:
1715:
1709:
1674:
1670:
1632:
1628:
1602:10.2741/3521
1592:
1588:
1558:10.2741/3521
1548:
1544:
1512:10.2741/3521
1502:
1498:
1488:
1456:(1): 32–39.
1453:
1449:
1425:
1416:
1407:
1398:
1337:4-1BB ligand
1323:
1310:
1306:
1285:
1282:Interactions
1260:
1241:
1238:Inflammation
1227:
1208:
1183:chondrocytes
1164:
1141:
1122:
1104:
1100:
1096:
1084:
1083:
1005:NP_001070977
1001:NP_001070976
998:
977:
950:NM_001077509
946:NM_001077508
943:
922:
898:
879:
853:
834:
808:
789:
769:
764:
399:
392:
358:151,030,559
345:150,999,019
119:External IDs
78:
6928:Quizartinib
6923:Midostaurin
6812:Peficitinib
6774:Ruxolitinib
6769:Peficitinib
6724:Baricitinib
6686:Ruxolitinib
6681:Peficitinib
6676:Oclacitinib
6671:Momelotinib
6656:Baricitinib
6651:Abrocitinib
6559:Interleukin
6517:Antibodies:
6474:Sifalimumab
6459:Faralimomab
6454:Anifrolumab
6451:Antibodies:
6273:Romiplostim
6258:Eltrombopag
6227:SCF (c-Kit)
6153:Antibodies:
6141:Regramostim
6075:Lenograstim
5256:(TNFRSF13C)
5248:(TNFRSF13B)
5240:(TNFRSF12A)
5232:(TNFRSF11B)
5224:(TNFRSF11A)
5216:(TNFRSF10D)
5208:(TNFRSF10C)
5200:(TNFRSF10B)
5192:(TNFRSF10A)
1943:. May 2016.
1845:(8): 1822.
1806:: 112–119.
1276:neutrophils
1272:macrophages
1225:secretion.
1099:(TNFRSF9),
461:gallbladder
457:granulocyte
97:Identifiers
6973:Immunology
6957:Categories
6913:Emfilermin
6764:Pacritinib
6666:Filgotinib
6632:inhibitors
6520:Emapalumab
6292:Interferon
6217:Agerafenib
6207:Mirimostim
6197:Lanimostim
6131:Milodistim
6080:Leridistim
6065:Filgrastim
5906:modulators
5331:(TNFRSF27)
5323:(TNFRSF25)
5315:(TNFRSF21)
5296:(TNFRSF19)
5288:(TNFRSF18)
5280:(TNFRSF17)
5272:(TNFRSF16)
5264:(TNFRSF14)
5149:(TNFRSF6B)
5109:(TNFRSF1B)
5101:(TNFRSF1A)
2857:(see also
1393:, May 2017
1372:, May 2017
1348:References
1325:Utomilumab
1320:Utomilumab
1191:astrocytes
1119:Expression
503:lymph node
495:blastocyst
429:lymph node
403:(ortholog)
257:7,943,165
244:7,915,871
140:HomoloGene
6938:Sunitinib
6933:Sorafenib
6842:ZM-449829
6832:WHI-P 154
6822:TCS-21311
6759:NSC-33994
6714:Atiprimod
6502:Agonists:
6484:Bifarcept
6309:Agonists:
6255:Agonists:
6187:Cilmostim
6184:Agonists:
6161:Namilumab
6118:Agonists:
6062:Agonists:
5951:Agonists:
5914:Chemokine
5615:prolactin
5173:(TNFRSF9)
5165:(TNFRSF8)
5157:(TNFRSF7)
5141:(TNFRSF6)
5133:(TNFRSF5)
5125:(TNFRSF4)
5117:(TNFRSF3)
2812:266744295
1635:: 66–72.
1195:microglia
1167:monocytes
1139:T cells.
1009:NP_035742
980:NP_001552
954:NM_011612
925:NM_001561
755:Orthologs
148:GeneCards
6968:Oncology
6837:ZM-39923
6754:NSC-7908
6719:AZD-1480
6610:instead.
6590:instead.
6570:instead.
6546:instead.
6464:MEDI-545
6238:instead.
6166:Otilimab
5969:CNTO-530
5925:instead.
5844:TGF-beta
5345:JAK-STAT
5293:TAJ/TROY
2851:Proteins
2804:38172595
2795:10834507
2759:17908504
2751:12101260
2716:12009595
2686:11970964
2651:11828369
2616:11804328
2581:10556203
2273:35822854
2154:15618293
2119:10604232
1920:36344331
1871:31013788
1820:26751393
1701:34027676
1649:29571029
1611:19273343
1567:19273343
1521:19273343
1480:38172595
1471:10834507
1389:–
1368:–
1342:Urelumab
1331:See also
1288:interact
1160:cytokine
1151:antibody
1057:Wikidata
734:Sources:
644:membrane
491:gastrula
453:monocyte
445:appendix
437:testicle
6779:SD-1008
5954:ARA-290
5840:Ser/Thr
5662:IL22RA2
5658:IL22RA1
5629:Type II
5558:IL12RB2
5554:IL12RB1
5537:IL12RB1
5436:β-chain
5405:IL13RA2
5401:IL13RA1
5363:γ-chain
4659:301–350
4453:251–300
4405:CD240CE
4202:201–250
3886:151–200
3609:101–150
2552:9607925
2543:2212301
2509:9541583
2474:9464265
2445:9418902
2402:9207223
2372:9045669
2337:8639902
2302:8262389
2265:8088337
2236:7622190
2207:2784565
2175:Bibcode
2098:8262389
2069:2784565
2037:Bibcode
2004:TNFRSF9
1998:TNFRSF9
1941:Reuters
1911:9742327
1862:6515339
1785:9418902
1736:9464265
1692:8483511
1391:Ensembl
1370:Ensembl
1187:neurons
1125:T cells
867:UniProt
822:Ensembl
761:Species
740:QuickGO
487:decidua
378:pattern
236:1p36.23
152:TNFRSF9
136:1101059
111:TNFRSF9
104:Aliases
33:TNFRSF9
18:TNFRSF9
6873:Others
6739:CYT387
6729:CHZ868
6618:Others
6374:IFNA21
6370:IFNA17
6366:IFNA16
6362:IFNA14
6358:IFNA13
6354:IFNA10
5859:family
5854:TGFBR2
5849:TGFBR1
5803:IL17RE
5798:IL17RD
5793:IL17RC
5788:IL17RB
5783:IL17RA
5760:IL18R1
5713:IFNGR2
5709:IFNGR1
5700:IFNAR2
5696:IFNAR1
5675:IL20RB
5671:IL20RA
5650:IL10RB
5646:IL10RA
5580:other
5510:IL27RA
5501:IL11RA
5469:GM-CSF
5354:Type I
5237:TweakR
5069:CMKLR1
5047:CX3CR1
4666:CD300A
4625:CDw293
4410:CD240D
4271:CD213a
4249:CDw210
4214:CD202b
4188:CDw199
4183:CDw198
3837:CD140b
3269:51–100
2810:
2802:
2792:
2757:
2749:
2714:
2684:
2649:
2614:
2579:
2550:
2540:
2507:
2472:
2443:
2436:121523
2433:
2400:
2370:
2335:
2300:
2271:
2263:
2234:
2205:
2198:286825
2195:
2152:
2117:
2096:
2067:
2060:286825
2057:
1995:Human
1918:
1908:
1869:
1859:
1818:
1783:
1776:121523
1773:
1734:
1699:
1689:
1647:
1609:
1565:
1519:
1478:
1468:
1177:, and
1148:B cell
1103:, and
1043:search
1041:PubMed
900:P20334
881:Q07011
777:Entrez
549:BioGPS
519:morula
515:uterus
499:thymus
128:602250
6413:IFNB3
6409:IFNB1
6350:IFNA8
6346:IFNA7
6342:IFNA6
6338:IFNA5
6334:IFNA4
6330:IFNA2
6326:IFNA1
5828:CSF1R
5756:IL18R
5749:IL1R2
5744:IL1R1
5680:IL28R
5667:IL20R
5654:IL22R
5642:IL10R
5592:G-CSF
5574:Other
5563:IL23R
5550:IL12R
5527:CNTFR
5492:IL6RA
5479:gp130
5462:IL5RA
5453:IL3RA
5424:IL21R
5414:IL7RA
5397:IL13R
5388:IL15R
5384:IL2RB
5380:IL2RA
5328:EDA2R
5305:21-27
5253:BAFFR
5182:11-20
5170:CD137
5122:CD134
5106:TNFR2
5098:TNFR1
5064:CCBP2
5043:CX3C
5037:Other
5028:CXCR7
5023:CXCR6
5018:CXCR5
5013:CXCR4
5008:CXCR3
5001:CXCR2
4996:CXCR1
4973:CCR10
4933:CCRL2
4923:CCRL1
4901:GPCRs
4846:CD350
4841:CD349
4836:CD344
4831:CD340
4826:CD339
4821:CD338
4816:CD337
4811:CD336
4806:CD335
4801:CD334
4796:CD333
4791:CD332
4786:CD331
4781:CD329
4776:CD328
4771:CD327
4766:CD326
4761:CD325
4756:CD324
4751:CD322
4746:CD321
4741:CD320
4736:CD318
4731:CD317
4726:CD316
4721:CD315
4716:CD314
4711:CD312
4706:CD309
4701:CD307
4696:CD306
4691:CD305
4686:CD304
4681:CD303
4676:CD302
4671:CD301
4650:CD299
4645:CD298
4640:CD297
4635:CD295
4630:CD294
4620:CD292
4615:CD290
4610:CD289
4605:CD288
4600:CD286
4595:CD284
4590:CD283
4585:CD282
4580:CD281
4575:CD280
4570:CD279
4565:CD278
4560:CD276
4555:CD275
4550:CD274
4545:CD273
4540:CD272
4535:CD271
4530:CD269
4525:CD268
4520:CD267
4515:CD266
4510:CD265
4505:CD264
4500:CD263
4495:CD262
4490:CD261
4485:CD258
4480:CD257
4475:CD256
4470:CD254
4465:CD253
4460:CD252
4444:CD249
4439:CD248
4435:CD247
4430:CD246
4425:CD244
4420:CD243
4415:CD241
4400:CD239
4395:CD238
4390:CD236
4373:CD235
4368:CD234
4363:CD233
4358:CD230
4353:CD229
4348:CD228
4343:CD227
4338:CD226
4333:CD225
4328:CD224
4323:CD223
4318:CD222
4313:CD221
4308:CD220
4293:CD218
4288:CD217
4266:CD212
4244:CD209
4239:CD208
4234:CD207
4229:CD206
4224:CD205
4219:CD204
4209:CD201
4193:CD200
4178:CD197
4173:CD196
4168:CD195
4163:CD194
4158:CD193
4153:CD192
4148:CD191
4143:CD186
4138:CD185
4133:CD184
4128:CD183
4123:CD182
4118:CD181
4113:CD180
4096:CD179
4091:CD178
4086:CD177
4081:CD174
4059:CD172
4054:CD171
4049:CD170
4044:CD169
4039:CD168
4022:CD167
4017:CD166
4012:CD164
4007:CD163
4002:CD162
3997:CD161
3992:CD160
3975:CD159
3945:CD158
3940:CD157
3918:CD156
3913:CD155
3908:CD154
3903:CD153
3898:CD152
3893:CD151
3877:CD150
3872:CD148
3867:CD147
3862:CD146
3857:CD144
3852:CD143
3847:CD142
3842:CD141
3832:CD138
3827:CD137
3822:CD136
3817:CD135
3812:CD134
3807:CD133
3802:CD132
3797:CD131
3792:CD130
3787:CD129
3782:CD127
3777:CD126
3772:CD125
3767:CD124
3762:CD123
3757:CD122
3740:CD121
3723:CD120
3718:CD119
3713:CD118
3708:CD117
3703:CD116
3698:CD115
3693:CD114
3688:CD113
3683:CD112
3678:CD111
3673:CD110
3668:CD109
3663:CD108
3646:CD107
3641:CD106
3636:CD105
3631:CD104
3626:CD103
3621:CD102
3616:CD101
3600:CD100
2808:S2CID
2755:S2CID
2561:Blood
2315:Blood
2269:S2CID
1961:(PDF)
1292:TRAF2
1290:with
1101:4-1BB
1085:CD137
810:21942
770:Mouse
765:Human
736:Amigo
523:blood
441:blood
401:Mouse
394:Human
341:Start
276:Mouse
240:Start
173:Human
6852:TYK2
6794:JAK3
6706:JAK2
6643:JAK1
6608:here
6606:See
6588:here
6586:See
6579:TGFβ
6568:here
6566:See
6544:here
6236:here
6234:See
5923:here
5921:See
5778:IL17
5692:-α/β
5522:LIFR
5517:OSMR
5458:IL5R
5449:IL3R
5419:IL9R
5410:IL7R
5393:IL4R
5376:IL2R
5285:GITR
5277:BCMA
5269:NGFR
5261:HVEM
5245:TACI
5221:RANK
5213:DcR2
5205:DcR1
5162:CD30
5154:CD27
5146:DcR3
5130:CD40
5114:LTBR
5091:1-10
5057:XCR1
4991:IL-8
4968:CCR9
4963:CCR8
4958:CCR7
4953:CCR6
4948:CCR5
4943:CCR4
4938:CCR3
4928:CCR2
4919:CCR1
3595:CD99
3590:CD98
3585:CD97
3580:CD96
3575:CD95
3570:CD94
3565:CD93
3560:CD92
3556:CD91
3551:CD90
3546:CD89
3541:CD88
3536:CD87
3531:CD86
3494:CD85
3489:CD84
3484:CD83
3479:CD82
3474:CD81
3469:CD80
3452:CD79
3447:CD78
3442:CD74
3437:CD73
3432:CD72
3427:CD71
3422:CD70
3417:CD69
3412:CD68
3375:CD66
3353:CD64
3348:CD63
3326:CD62
3321:CD61
3316:CD59
3311:CD58
3306:CD57
3301:CD56
3296:CD55
3291:CD54
3286:CD53
3281:CD52
3276:CD51
3260:CD50
3223:CD49
3218:CD48
3213:CD47
3208:CD46
3203:CD45
3198:CD44
3193:CD43
3166:CD42
3161:CD41
3156:CD40
3151:CD39
3146:CD38
3141:CD37
3136:CD36
3131:CD35
3126:CD34
3121:CD33
3104:CD32
3099:CD31
3094:CD30
3089:CD29
3084:CD28
3079:CD27
3074:CD26
3069:CD25
3064:CD24
3059:CD23
3054:CD22
3049:CD21
3044:CD20
3039:CD19
3034:CD18
3017:CD16
3012:CD15
3007:CD14
3002:CD13
2975:CD11
2970:CD10
2867:1–50
2800:PMID
2747:PMID
2712:PMID
2682:PMID
2647:PMID
2612:PMID
2577:PMID
2548:PMID
2505:PMID
2470:PMID
2441:PMID
2398:PMID
2368:PMID
2333:PMID
2298:PMID
2282:Gene
2261:PMID
2232:PMID
2203:PMID
2150:PMID
2115:PMID
2094:PMID
2078:Gene
2065:PMID
1916:PMID
1867:PMID
1816:PMID
1781:PMID
1732:PMID
1697:PMID
1645:PMID
1607:PMID
1563:PMID
1517:PMID
1476:PMID
1274:and
1223:IL-1
1197:and
1137:CD8+
1135:and
1133:CD4+
791:3604
384:Bgee
332:Band
293:Chr.
231:Band
190:Chr.
144:1199
124:OMIM
81:1D0J
62:RCSB
59:PDBe
6626:JAK
6599:TNF
5934:CSF
5833:KIT
5823:Tyr
5739:IL1
5587:EPO
5320:DR3
5312:DR6
5197:DR5
5189:DR4
5053:XC
4983:CXC
2965:CD9
2953:CD8
2948:CD7
2943:CD6
2938:CD5
2933:CD4
2911:CD3
2906:CD2
2879:a-c
2874:CD1
2790:PMC
2780:doi
2737:doi
2704:doi
2672:doi
2668:168
2637:doi
2602:doi
2569:doi
2538:PMC
2530:doi
2526:187
2495:doi
2462:doi
2458:242
2431:PMC
2423:doi
2390:doi
2386:235
2358:doi
2354:272
2323:doi
2290:doi
2286:134
2253:doi
2224:doi
2193:PMC
2183:doi
2140:doi
2086:doi
2082:134
2055:PMC
2045:doi
1906:PMC
1898:doi
1857:PMC
1847:doi
1808:doi
1771:PMC
1763:doi
1724:doi
1720:242
1687:PMC
1679:doi
1637:doi
1633:272
1597:doi
1553:doi
1507:doi
1466:PMC
1458:doi
1201:).
1089:TNF
354:End
253:End
156:OMA
132:MGI
52:PDB
6959::
6411:,
6372:,
6368:,
6364:,
6360:,
6356:,
6352:,
6348:,
6344:,
6340:,
6336:,
6332:,
6328:,
5842::
5758:/
5711:/
5705:-γ
5694:/
5673:/
5669:/
5660:/
5656:/
5652:/
5648:/
5644:/
5610:GH
5608::
5506:27
5497:11
5460:/
5451:/
5412:/
5403:/
5399:/
5395:/
5386:/
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