297:
274:
171:
196:
303:
202:
3121:
50:
2268:
2052:
1781:
Jakubowski A, Browning B, Lukashev M, Sizing I, Thompson JS, Benjamin CD, Hsu YM, Ambrose C, Zheng TS, Burkly LC (January 2002). "Dual role for TWEAK in angiogenic regulation".
1845:
Harada N, Nakayama M, Nakano H, Fukuchi Y, Yagita H, Okumura K (December 2002). "Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells".
310:
209:
2284:
2746:
2212:
2334:
1909:
Tian XL, Kadaba R, You SA, Liu M, Timur AA, Yang L, Chen Q, Szafranski P, Rao S, Wu L, Housman DE, DiCorleto PE, Driscoll DJ, Borrow J, Wang Q (February 2004).
2766:
1389:
Maecker H, Varfolomeev E, Kischkel F, Lawrence D, LeBlanc H, Lee W, Hurst S, Danilenko D, Li J, Filvaroff E, Yang B, Daniel D, Ashkenazi A (December 2005).
2394:
2045:
812:
1473:
Wilhelm A, Shepherd EL, Amatucci A, Munir M, Reynolds G, Humphreys E, Resheq Y, Adams DH, Hübscher S, Burkly LC, Weston CJ, Afford SC (February 2016).
793:
132:
2737:
2726:
2702:
2192:
3162:
2081:
1475:"Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation"
3181:
2228:
2038:
1253:
1235:
2360:
1526:
Wiley SR, Winkles JA (2004). "TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor".
1129:
via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of
296:
2092:
1019:
273:
3046:
1012:
1438:
Burkly LC (June 2014). "TWEAK/Fn14 axis: the current paradigm of tissue injury-inducible function in the midst of complexities".
1375:
1222:
1201:
1711:
Wiley SR, Cassiano L, Lofton T, Davis-Smith T, Winkles JA, Lindner V, Liu H, Daniel TO, Smith CA, Fanslow WC (November 2001).
2757:
2459:
195:
170:
1218:
47:
1197:
3061:
112:
309:
208:
1109:
receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution.
1746:
Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, Kominami E, Okumura K, Yagita H (January 2002).
1660:
Kaptein A, Jansen M, Dilaver G, Kitson J, Dash L, Wang E, Owen MJ, Bodmer JL, Tschopp J, Farrow SN (November 2000).
302:
201:
3155:
3051:
2693:
2652:
2122:
1995:
Jin L, Nakao A, Nakayama M, Yamaguchi N, Kojima Y, Nakano N, Tsuboi R, Okumura K, Yagita H, Ogawa H (May 2004).
1812:"The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells"
857:
120:
1911:"Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome"
2405:
2101:
838:
2117:
1627:"TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand) mediate CD4+ T cell killing of antigen-presenting macrophages"
3186:
2790:
3148:
2602:
2597:
2548:
1166:
1102:
184:
2187:
1274:
Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C, Garcia I, Browning JL (December 1997).
2202:
2717:
2553:
2258:
2152:
1922:
1673:
1328:
103:, APO3L, DR3LG, TWEAK, TNLG4A, tumor necrosis factor superfamily member 12, TNF superfamily member 12
99:
2960:
2668:
2558:
2450:
2167:
2162:
2157:
2147:
1122:
2421:
2279:
2248:
2582:
2577:
2543:
2538:
2484:
2299:
2072:
2064:
1699:
1420:
1354:
144:
3071:
2375:
2365:
2355:
2289:
2238:
1960:
Kim SH, Kang YJ, Kim WJ, Woo DK, Lee Y, Kim DI, Park YB, Kwon BS, Park JE, Lee WH (April 2004).
1276:"TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis"
995:
974:
948:
927:
3000:
2990:
2980:
2917:
2642:
2345:
1810:
Kaplan MJ, Lewis EE, Shelden EA, Somers E, Pavlic R, McCune WJ, Richardson BC (November 2002).
3010:
2995:
2912:
2877:
2622:
2127:
2061:
2018:
1983:
1948:
1897:
1876:"Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death"
1862:
1833:
1798:
1769:
1734:
1691:
1648:
1613:
1578:
1543:
1504:
1455:
1412:
1346:
1297:
92:
40:
3132:
2937:
2112:
140:
2663:
2592:
2587:
2475:
2132:
2008:
1973:
1938:
1930:
1887:
1854:
1823:
1790:
1759:
1724:
1681:
1638:
1603:
1568:
1535:
1494:
1486:
1447:
1402:
1336:
1287:
1110:
389:
320:
264:
219:
2571:
1962:"TWEAK can induce pro-inflammatory cytokines and matrix metalloproteinase-9 in macrophages"
1874:
Nakayama M, Ishidoh K, Kojima Y, Harada N, Kominami E, Okumura K, Yagita H (January 2003).
3041:
3018:
2563:
2480:
2243:
1145:
Excessive activation of the TWEAK pathway in chronic injury has been described to promote
364:
1926:
1677:
1332:
2902:
2892:
2819:
2436:
2426:
2350:
2182:
1943:
1910:
1499:
1474:
1118:
1858:
1729:
1712:
1686:
1661:
1557:"The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity"
1539:
1341:
1316:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
641:
636:
631:
626:
621:
616:
611:
595:
590:
585:
580:
3175:
2470:
2253:
2172:
2013:
1996:
567:
1703:
1358:
124:
3076:
3056:
2975:
2965:
2907:
2854:
2784:
2683:
2627:
2314:
2304:
2294:
2197:
2177:
2142:
2137:
1662:"Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)"
1424:
1158:
1150:
1134:
382:
161:
1713:"A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis"
1315:
Marsters SA, Sheridan JP, Pitti RM, Brush J, Goddard A, Ashkenazi A (April 1998).
1828:
1811:
148:
3086:
3081:
2985:
2970:
2942:
2932:
2927:
2882:
2849:
2844:
2839:
2834:
2829:
2814:
2809:
2632:
2617:
2612:
2431:
2416:
2233:
1643:
1626:
1258:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1240:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1174:
1130:
2030:
1892:
1875:
1764:
1747:
1451:
1407:
1390:
465:
2922:
2824:
2678:
2223:
281:
178:
128:
1292:
1275:
3096:
3091:
2872:
2319:
1608:
1591:
1376:"Entrez Gene: TNFSF12 tumor necrosis factor (ligand) superfamily, member 12"
1146:
1126:
1106:
757:
525:
403:
348:
335:
247:
234:
136:
2022:
1987:
1952:
1901:
1866:
1837:
1802:
1773:
1738:
1695:
1652:
1617:
1582:
1547:
1508:
1459:
1416:
1794:
1350:
1317:"Identification of a ligand for the death-domain-containing receptor Apo3"
1301:
1059:
1054:
2324:
1978:
1961:
1170:
1154:
1114:
1098:
1043:
902:
883:
1934:
3128:
1079:
869:
824:
3120:
1997:"Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes"
1490:
69:
2897:
2887:
2532:
2528:
2524:
2520:
2516:
2512:
1590:
Lynch CN, Wang YC, Lund JK, Chen YW, Leal JA, Wiley SR (March 1999).
1027:
779:
1097:
TWEAK was discovered in 1997. The protein encoded by this gene is a
1592:"TWEAK induces angiogenesis and proliferation of endothelial cells"
1113:
are the main source of TWEAK including human resting and activated
2567:
2508:
2504:
2500:
2496:
2492:
2488:
2385:
1555:
Campbell S, Michaelson J, Burkly L, Putterman C (September 2004).
1391:"TWEAK attenuates the transition from innate to adaptive immunity"
1162:
1573:
1556:
742:
738:
2952:
2864:
2801:
1086:
116:
2034:
1625:
Kaplan MJ, Ray D, Mo RR, Yung RL, Richardson BC (March 2000).
1165:
disease, for example, TWEAK expression is enhanced and causes
708:
positive regulation of extrinsic apoptotic signaling pathway
1105:(TNF) ligand family. This protein is a ligand for the FN14/
372:
3136:
2193:
Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
663:
positive regulation of endothelial cell proliferation
537:
3031:
3009:
2951:
2863:
2800:
2783:
2776:
2756:
2736:
2716:
2692:
2651:
2458:
2449:
2404:
2384:
2333:
2267:
2211:
2100:
2091:
2071:
1847:
988:
967:
941:
920:
1214:
1212:
1210:
1193:
1191:
1189:
1072:Tumor necrosis factor ligand superfamily member 12
319:
218:
2285:Granulocyte macrophage colony-stimulating factor
678:tumor necrosis factor-mediated signaling pathway
668:positive regulation of protein catabolic process
1748:"Multiple pathways of TWEAK-induced cell death"
16:Protein-coding gene in the species Homo sapiens
1219:GRCm38: Ensembl release 89: ENSMUSG00000097328
3156:
2046:
1269:
1267:
8:
1198:GRCh38: Ensembl release 89: ENSG00000239697
3163:
3149:
3052:Leukemia/leukocyte inhibitory factor (LIF)
2797:
2780:
2455:
2097:
2053:
2039:
2031:
753:
563:
360:
259:
156:
58:
3047:FMS-like tyrosine kinase 3 ligand (FLT3L)
2476:Interferon alpha (interferon alfa, IFN-α)
2012:
1977:
1942:
1891:
1827:
1763:
1728:
1685:
1642:
1607:
1572:
1498:
1406:
1340:
1291:
728:regulation of signaling receptor activity
3069:Additional cytokine receptor modulators:
2001:The Journal of Investigative Dermatology
1370:
1368:
1185:
1133:cells, and thus acts as a regulator of
2893:Cucurbitacin I (elatericin B, JSI-124)
591:tumor necrosis factor receptor binding
18:
2229:Granulocyte colony-stimulating factor
1442:. The TNF family - challenges ahead.
1076:TNF-related weak inducer of apoptosis
673:extrinsic apoptotic signaling pathway
627:integral component of plasma membrane
324:
285:
280:
223:
182:
177:
7:
3117:
3115:
2588:Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
2361:Macrophage colony-stimulating factor
1528:Cytokine & Growth Factor Reviews
1169:, which are key regulators of liver
3062:Thymic stromal lymphopoietin (TSLP)
1596:The Journal of Biological Chemistry
1280:The Journal of Biological Chemistry
683:positive regulation of angiogenesis
3135:. You can help Knowledge (XXG) by
985:
964:
938:
917:
893:
874:
848:
829:
803:
784:
688:multicellular organism development
542:
460:
398:
377:
14:
1149:tissue changes including chronic
1082:that in humans is encoded by the
3119:
2014:10.1111/j.0022-202X.2004.22419.x
308:
301:
295:
272:
207:
200:
194:
169:
2593:Interferon omega (IFN-ω, IFNW1)
637:perinuclear region of cytoplasm
612:integral component of membrane
526:More reference expression data
1:
1859:10.1016/S0006-291X(02)02670-0
1730:10.1016/S1074-7613(01)00232-1
1687:10.1016/S0014-5793(00)02219-5
1540:10.1016/S1359-6101(03)00019-4
1342:10.1016/S0960-9822(98)70204-0
480:tunica media of zone of aorta
446:muscle layer of sigmoid colon
293:
192:
3182:Genes on human chromosome 17
1829:10.4049/jimmunol.169.10.6020
2437:Thrombopoietin (THPO, MGDF)
2203:Pegol sihematide (EPO-018B)
2123:Carbamylated erythropoietin
1644:10.4049/jimmunol.164.6.2897
703:apoptotic signaling pathway
3203:
3114:
1893:10.4049/jimmunol.170.1.341
1765:10.4049/jimmunol.168.2.734
1452:10.1016/j.smim.2014.02.006
1408:10.1016/j.cell.2005.09.022
713:endothelial cell migration
596:signaling receptor binding
2986:Tofacitinib (tasocitinib)
2943:Tofacitinib (tasocitinib)
2850:Tofacitinib (tasocitinib)
1254:"Mouse PubMed Reference:"
1236:"Human PubMed Reference:"
1058:
1053:
1049:
1042:
1026:
1007:
992:
971:
960:
945:
924:
913:
900:
896:
881:
877:
868:
855:
851:
836:
832:
823:
810:
806:
791:
787:
778:
763:
756:
752:
736:
566:
562:
550:
545:
536:
523:
472:
463:
426:Descending thoracic aorta
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
2664:Interferon gamma (IFN-γ)
1479:The Journal of Pathology
1293:10.1074/jbc.272.51.32401
1020:Chr 11: 69.58 – 69.59 Mb
2564:Interferon beta (IFN-β)
1783:Journal of Cell Science
1609:10.1074/jbc.274.13.8455
1561:Frontiers in Bioscience
3131:-related article is a
3042:Cardiotrophin 1 (CT-1)
1440:Seminars in Immunology
1167:hepatic stellate cells
1013:Chr 17: 7.55 – 7.56 Mb
476:neural layer of retina
3039:Additional cytokines:
2966:Decernotinib (VX-509)
2603:Peginterferon alfa-2b
2598:Peginterferon alfa-2a
2118:Asialo erythropoietin
1880:Journal of Immunology
1816:Journal of Immunology
1795:10.1242/jcs.115.2.267
1752:Journal of Immunology
1631:Journal of Immunology
1141:Clinical significance
1103:tumor necrosis factor
500:stroma of bone marrow
414:right coronary artery
287:Chromosome 11 (mouse)
185:Chromosome 17 (human)
2554:Interferon alfacon-1
2183:Erythropoietin (EPO)
1979:10.1253/circj.68.396
1123:natural killer cells
1101:that belongs to the
658:cell differentiation
632:extracellular region
430:left coronary artery
62:List of PDB id codes
35:Available structures
2701:See IL-28R (IFNLR)
2669:Interferon gamma 1b
2559:Interferon alpha-n3
1966:Circulation Journal
1935:10.1038/nature02320
1927:2004Natur.427..640T
1678:2000FEBSL.485..135K
1333:1998CBio....8..525M
1125:. TWEAK can induce
718:signal transduction
642:extracellular space
149:TNFSF12 - orthologs
3057:Oncostatin M (OSM)
2583:Interferon beta 1b
2578:Interferon beta 1a
2549:Interferon alfa n1
2544:Interferon alfa 2b
2539:Interferon alfa 2a
2373:Kinase inhibitors:
858:ENSMUSG00000097328
651:Biological process
605:Cellular component
574:Molecular function
3144:
3143:
3109:
3108:
3105:
3104:
3027:
3026:
2794:
2712:
2711:
2445:
2444:
2188:Erythropoietin-Fc
2062:Cytokine receptor
1491:10.1002/path.4707
1069:
1068:
1065:
1064:
1038:
1037:
1003:
1002:
982:
981:
956:
955:
935:
934:
909:
908:
890:
889:
864:
863:
845:
844:
819:
818:
800:
799:
748:
747:
723:apoptotic process
581:cytokine activity
558:
557:
554:
553:
532:
531:
519:
518:
508:lactiferous gland
457:
456:
355:
354:
254:
253:
81:
80:
77:
76:
45:Ortholog search:
3194:
3165:
3158:
3151:
3123:
3116:
2798:
2788:
2781:
2640:Decoy receptors:
2456:
2133:Darbepoetin alfa
2098:
2055:
2048:
2041:
2032:
2026:
2016:
1991:
1981:
1956:
1946:
1905:
1895:
1870:
1841:
1831:
1806:
1789:(Pt 2): 267–74.
1777:
1767:
1742:
1732:
1707:
1689:
1656:
1646:
1621:
1611:
1586:
1576:
1567:(1–3): 2273–84.
1551:
1513:
1512:
1502:
1470:
1464:
1463:
1435:
1429:
1428:
1410:
1386:
1380:
1379:
1372:
1363:
1362:
1344:
1312:
1306:
1305:
1295:
1286:(51): 32401–10.
1271:
1262:
1261:
1250:
1244:
1243:
1232:
1226:
1216:
1205:
1195:
1051:
1050:
1022:
1015:
998:
986:
977:
965:
961:RefSeq (protein)
951:
939:
930:
918:
894:
875:
849:
830:
804:
785:
754:
564:
543:
528:
468:
466:Top expressed in
461:
434:popliteal artery
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
3202:
3201:
3197:
3196:
3195:
3193:
3192:
3191:
3172:
3171:
3170:
3169:
3112:
3110:
3101:
3023:
3019:Deucravacitinib
3005:
2947:
2859:
2787:
2772:
2752:
2732:
2708:
2688:
2647:
2481:Interferon alfa
2441:
2400:
2380:
2329:
2263:
2259:Pegnartograstim
2244:Lipegfilgrastim
2207:
2153:Epoetin epsilon
2087:
2067:
2059:
2029:
1994:
1959:
1921:(6975): 640–5.
1908:
1873:
1844:
1809:
1780:
1745:
1710:
1672:(2–3): 135–41.
1659:
1637:(6): 2897–904.
1624:
1589:
1554:
1525:
1521:
1519:Further reading
1516:
1472:
1471:
1467:
1437:
1436:
1432:
1388:
1387:
1383:
1374:
1373:
1366:
1321:Current Biology
1314:
1313:
1309:
1273:
1272:
1265:
1252:
1251:
1247:
1234:
1233:
1229:
1217:
1208:
1196:
1187:
1183:
1143:
1119:dendritic cells
1095:
1060:View/Edit Mouse
1055:View/Edit Human
1018:
1011:
1008:Location (UCSC)
994:
973:
947:
926:
839:ENSG00000239697
732:
698:immune response
646:
622:plasma membrane
600:
586:protein binding
524:
515:
512:muscle of thigh
510:
506:
502:
498:
496:ascending aorta
494:
490:
486:
482:
478:
464:
453:
448:
444:
440:
438:tibial arteries
436:
432:
428:
424:
422:ascending aorta
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
3200:
3198:
3190:
3189:
3184:
3174:
3173:
3168:
3167:
3160:
3153:
3145:
3142:
3141:
3124:
3107:
3106:
3103:
3102:
3100:
3099:
3094:
3089:
3084:
3079:
3074:
3065:
3064:
3059:
3054:
3049:
3044:
3035:
3033:
3029:
3028:
3025:
3024:
3022:
3021:
3015:
3013:
3007:
3006:
3004:
3003:
2998:
2993:
2988:
2983:
2978:
2973:
2968:
2963:
2961:Cercosporamide
2957:
2955:
2949:
2948:
2946:
2945:
2940:
2935:
2930:
2925:
2920:
2915:
2910:
2905:
2903:Deuruxolitinib
2900:
2895:
2890:
2885:
2880:
2875:
2869:
2867:
2861:
2860:
2858:
2857:
2852:
2847:
2842:
2837:
2832:
2827:
2822:
2820:Deuruxolitinib
2817:
2812:
2806:
2804:
2795:
2778:
2774:
2773:
2771:
2770:
2762:
2760:
2754:
2753:
2751:
2750:
2742:
2740:
2734:
2733:
2731:
2730:
2722:
2720:
2714:
2713:
2710:
2709:
2707:
2706:
2698:
2696:
2694:IFNLR (λ, III)
2690:
2689:
2687:
2686:
2681:
2672:
2671:
2666:
2657:
2655:
2649:
2648:
2646:
2645:
2636:
2635:
2630:
2625:
2620:
2615:
2606:
2605:
2600:
2595:
2590:
2585:
2580:
2575:
2561:
2556:
2551:
2546:
2541:
2536:
2478:
2473:
2464:
2462:
2460:IFNAR (α/β, I)
2453:
2447:
2446:
2443:
2442:
2440:
2439:
2434:
2429:
2427:Promegapoietin
2424:
2419:
2410:
2408:
2406:Thrombopoietin
2402:
2401:
2399:
2398:
2390:
2388:
2382:
2381:
2379:
2378:
2369:
2368:
2363:
2358:
2353:
2351:Interleukin-34
2348:
2339:
2337:
2331:
2330:
2328:
2327:
2322:
2317:
2308:
2307:
2302:
2297:
2292:
2287:
2282:
2273:
2271:
2265:
2264:
2262:
2261:
2256:
2251:
2246:
2241:
2236:
2231:
2226:
2217:
2215:
2209:
2208:
2206:
2205:
2200:
2195:
2190:
2185:
2180:
2175:
2170:
2165:
2160:
2155:
2150:
2145:
2140:
2135:
2130:
2125:
2120:
2115:
2106:
2104:
2102:Erythropoietin
2095:
2089:
2088:
2086:
2085:
2077:
2075:
2069:
2068:
2060:
2058:
2057:
2050:
2043:
2035:
2028:
2027:
1992:
1957:
1906:
1871:
1842:
1822:(10): 6020–9.
1807:
1778:
1743:
1708:
1657:
1622:
1602:(13): 8455–9.
1587:
1552:
1534:(3–4): 241–9.
1522:
1520:
1517:
1515:
1514:
1465:
1430:
1381:
1364:
1307:
1263:
1245:
1227:
1206:
1184:
1182:
1179:
1142:
1139:
1094:
1091:
1074:also known as
1067:
1066:
1063:
1062:
1057:
1047:
1046:
1040:
1039:
1036:
1035:
1033:
1031:
1024:
1023:
1016:
1009:
1005:
1004:
1001:
1000:
990:
989:
983:
980:
979:
969:
968:
962:
958:
957:
954:
953:
943:
942:
936:
933:
932:
922:
921:
915:
911:
910:
907:
906:
898:
897:
891:
888:
887:
879:
878:
872:
866:
865:
862:
861:
853:
852:
846:
843:
842:
834:
833:
827:
821:
820:
817:
816:
808:
807:
801:
798:
797:
789:
788:
782:
776:
775:
770:
765:
761:
760:
750:
749:
746:
745:
734:
733:
731:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
654:
652:
648:
647:
645:
644:
639:
634:
629:
624:
619:
614:
608:
606:
602:
601:
599:
598:
593:
588:
583:
577:
575:
571:
570:
560:
559:
556:
555:
552:
551:
548:
547:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
473:
470:
469:
458:
455:
454:
452:
451:
447:
443:
442:gastric mucosa
439:
435:
431:
427:
423:
419:
418:thoracic aorta
415:
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
284:
278:
277:
269:
268:
256:
255:
252:
251:
243:
239:
238:
230:
227:
222:
216:
215:
206:
199:
193:
189:
188:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3199:
3188:
3187:Protein stubs
3185:
3183:
3180:
3179:
3177:
3166:
3161:
3159:
3154:
3152:
3147:
3146:
3140:
3138:
3134:
3130:
3125:
3122:
3118:
3113:
3098:
3095:
3093:
3090:
3088:
3085:
3083:
3080:
3078:
3075:
3073:
3070:
3067:
3066:
3063:
3060:
3058:
3055:
3053:
3050:
3048:
3045:
3043:
3040:
3037:
3036:
3034:
3030:
3020:
3017:
3016:
3014:
3012:
3008:
3002:
2999:
2997:
2994:
2992:
2989:
2987:
2984:
2982:
2979:
2977:
2974:
2972:
2969:
2967:
2964:
2962:
2959:
2958:
2956:
2954:
2950:
2944:
2941:
2939:
2936:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2906:
2904:
2901:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2881:
2879:
2876:
2874:
2871:
2870:
2868:
2866:
2862:
2856:
2853:
2851:
2848:
2846:
2843:
2841:
2838:
2836:
2833:
2831:
2828:
2826:
2823:
2821:
2818:
2816:
2813:
2811:
2808:
2807:
2805:
2803:
2799:
2796:
2792:
2786:
2782:
2779:
2775:
2768:
2764:
2763:
2761:
2759:
2755:
2748:
2744:
2743:
2741:
2739:
2735:
2728:
2724:
2723:
2721:
2719:
2715:
2704:
2700:
2699:
2697:
2695:
2691:
2685:
2682:
2680:
2677:
2674:
2673:
2670:
2667:
2665:
2662:
2659:
2658:
2656:
2654:
2653:IFNGR (γ, II)
2650:
2644:
2641:
2638:
2637:
2634:
2631:
2629:
2626:
2624:
2621:
2619:
2616:
2614:
2611:
2608:
2607:
2604:
2601:
2599:
2596:
2594:
2591:
2589:
2586:
2584:
2581:
2579:
2576:
2573:
2569:
2565:
2562:
2560:
2557:
2555:
2552:
2550:
2547:
2545:
2542:
2540:
2537:
2534:
2530:
2526:
2522:
2518:
2514:
2510:
2506:
2502:
2498:
2494:
2490:
2486:
2482:
2479:
2477:
2474:
2472:
2471:Albinterferon
2469:
2466:
2465:
2463:
2461:
2457:
2454:
2452:
2448:
2438:
2435:
2433:
2430:
2428:
2425:
2423:
2420:
2418:
2415:
2412:
2411:
2409:
2407:
2403:
2396:
2392:
2391:
2389:
2387:
2383:
2377:
2374:
2371:
2370:
2367:
2364:
2362:
2359:
2357:
2354:
2352:
2349:
2347:
2344:
2341:
2340:
2338:
2336:
2332:
2326:
2323:
2321:
2318:
2316:
2313:
2310:
2309:
2306:
2303:
2301:
2298:
2296:
2293:
2291:
2288:
2286:
2283:
2281:
2278:
2275:
2274:
2272:
2270:
2269:GM-CSF (CSF2)
2266:
2260:
2257:
2255:
2254:Pegfilgrastim
2252:
2250:
2247:
2245:
2242:
2240:
2237:
2235:
2232:
2230:
2227:
2225:
2222:
2219:
2218:
2216:
2214:
2210:
2204:
2201:
2199:
2196:
2194:
2191:
2189:
2186:
2184:
2181:
2179:
2176:
2174:
2173:Epoetin theta
2171:
2169:
2168:Epoetin omega
2166:
2164:
2163:Epoetin kappa
2161:
2159:
2158:Epoetin gamma
2156:
2154:
2151:
2149:
2148:Epoetin delta
2146:
2144:
2141:
2139:
2136:
2134:
2131:
2129:
2126:
2124:
2121:
2119:
2116:
2114:
2111:
2108:
2107:
2105:
2103:
2099:
2096:
2094:
2090:
2083:
2079:
2078:
2076:
2074:
2070:
2066:
2063:
2056:
2051:
2049:
2044:
2042:
2037:
2036:
2033:
2024:
2020:
2015:
2010:
2007:(5): 1175–9.
2006:
2002:
1998:
1993:
1989:
1985:
1980:
1975:
1971:
1967:
1963:
1958:
1954:
1950:
1945:
1940:
1936:
1932:
1928:
1924:
1920:
1916:
1912:
1907:
1903:
1899:
1894:
1889:
1885:
1881:
1877:
1872:
1868:
1864:
1860:
1856:
1853:(3): 488–93.
1852:
1848:
1843:
1839:
1835:
1830:
1825:
1821:
1817:
1813:
1808:
1804:
1800:
1796:
1792:
1788:
1784:
1779:
1775:
1771:
1766:
1761:
1758:(2): 734–43.
1757:
1753:
1749:
1744:
1740:
1736:
1731:
1726:
1723:(5): 837–46.
1722:
1718:
1714:
1709:
1705:
1701:
1697:
1693:
1688:
1683:
1679:
1675:
1671:
1667:
1663:
1658:
1654:
1650:
1645:
1640:
1636:
1632:
1628:
1623:
1619:
1615:
1610:
1605:
1601:
1597:
1593:
1588:
1584:
1580:
1575:
1570:
1566:
1562:
1558:
1553:
1549:
1545:
1541:
1537:
1533:
1529:
1524:
1523:
1518:
1510:
1506:
1501:
1496:
1492:
1488:
1485:(1): 109–21.
1484:
1480:
1476:
1469:
1466:
1461:
1457:
1453:
1449:
1446:(3): 229–36.
1445:
1441:
1434:
1431:
1426:
1422:
1418:
1414:
1409:
1404:
1401:(5): 931–44.
1400:
1396:
1392:
1385:
1382:
1377:
1371:
1369:
1365:
1360:
1356:
1352:
1348:
1343:
1338:
1334:
1330:
1326:
1322:
1318:
1311:
1308:
1303:
1299:
1294:
1289:
1285:
1281:
1277:
1270:
1268:
1264:
1259:
1255:
1249:
1246:
1241:
1237:
1231:
1228:
1224:
1220:
1215:
1213:
1211:
1207:
1203:
1199:
1194:
1192:
1190:
1186:
1180:
1178:
1176:
1172:
1168:
1164:
1161:. In chronic
1160:
1156:
1152:
1148:
1140:
1138:
1136:
1132:
1128:
1124:
1120:
1116:
1112:
1108:
1104:
1100:
1092:
1090:
1088:
1085:
1081:
1078:(TWEAK) is a
1077:
1073:
1061:
1056:
1052:
1048:
1045:
1041:
1034:
1032:
1029:
1025:
1021:
1017:
1014:
1010:
1006:
999:
997:
991:
987:
984:
978:
976:
970:
966:
963:
959:
952:
950:
944:
940:
937:
931:
929:
923:
919:
916:
914:RefSeq (mRNA)
912:
905:
904:
899:
895:
892:
886:
885:
880:
876:
873:
871:
867:
860:
859:
854:
850:
847:
841:
840:
835:
831:
828:
826:
822:
815:
814:
809:
805:
802:
796:
795:
790:
786:
783:
781:
777:
774:
771:
769:
766:
762:
759:
755:
751:
744:
740:
735:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
655:
653:
650:
649:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
613:
610:
609:
607:
604:
603:
597:
594:
592:
589:
587:
584:
582:
579:
578:
576:
573:
572:
569:
568:Gene ontology
565:
561:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
474:
471:
467:
462:
459:
450:apex of heart
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
412:
409:
405:
400:
397:
396:
393:
391:
387:
385:
384:
380:
379:
376:
374:
370:
366:
362:
358:
350:
345:
341:
337:
332:
326:11|11 B3
322:
318:
311:
304:
298:
291:
283:
279:
275:
270:
266:
261:
257:
249:
244:
240:
236:
231:
221:
217:
210:
203:
197:
190:
186:
180:
176:
172:
167:
163:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
3137:expanding it
3126:
3111:
3077:Lestaurtinib
3068:
3038:
2976:Ritlecitinib
2908:Lestaurtinib
2855:Upadacitinib
2684:Fontolizumab
2675:
2660:
2639:
2628:Rontalizumab
2609:
2467:
2422:Pegacaristim
2413:
2372:
2342:
2335:M-CSF (CSF1)
2315:Mavrilimumab
2311:
2305:Sargramostim
2295:Molgramostim
2280:Ecogramostim
2276:
2249:Nartograstim
2220:
2213:G-CSF (CSF3)
2198:Peginesatide
2178:Epoetin zeta
2143:Epoetin beta
2138:Epoetin alfa
2109:
2004:
2000:
1972:(4): 396–9.
1969:
1965:
1918:
1914:
1886:(1): 341–8.
1883:
1879:
1850:
1846:
1819:
1815:
1786:
1782:
1755:
1751:
1720:
1716:
1669:
1666:FEBS Letters
1665:
1634:
1630:
1599:
1595:
1574:10.2741/1395
1564:
1560:
1531:
1527:
1482:
1478:
1468:
1443:
1439:
1433:
1398:
1394:
1384:
1327:(9): 525–8.
1324:
1320:
1310:
1283:
1279:
1257:
1248:
1239:
1230:
1159:angiogenesis
1151:inflammation
1147:pathological
1144:
1135:angiogenesis
1096:
1083:
1075:
1071:
1070:
993:
972:
946:
925:
901:
882:
856:
837:
811:
792:
772:
767:
693:angiogenesis
504:aortic valve
388:
381:
108:External IDs
67:
3087:Quizartinib
3082:Midostaurin
2971:Peficitinib
2933:Ruxolitinib
2928:Peficitinib
2883:Baricitinib
2845:Ruxolitinib
2840:Peficitinib
2835:Oclacitinib
2830:Momelotinib
2815:Baricitinib
2810:Abrocitinib
2718:Interleukin
2676:Antibodies:
2633:Sifalimumab
2618:Faralimomab
2613:Anifrolumab
2610:Antibodies:
2432:Romiplostim
2417:Eltrombopag
2386:SCF (c-Kit)
2312:Antibodies:
2300:Regramostim
2234:Lenograstim
1175:proliferate
1131:endothelial
347:69,586,675
334:69,577,076
86:Identifiers
3176:Categories
3072:Emfilermin
2923:Pacritinib
2825:Filgotinib
2791:inhibitors
2679:Emapalumab
2451:Interferon
2376:Agerafenib
2366:Mirimostim
2356:Lanimostim
2290:Milodistim
2239:Leridistim
2224:Filgrastim
2065:modulators
1225:, May 2017
1204:, May 2017
1181:References
1111:Leukocytes
492:right lung
392:(ortholog)
246:7,557,890
233:7,549,058
129:HomoloGene
3097:Sunitinib
3092:Sorafenib
3001:ZM-449829
2991:WHI-P 154
2981:TCS-21311
2918:NSC-33994
2873:Atiprimod
2661:Agonists:
2643:Bifarcept
2468:Agonists:
2414:Agonists:
2346:Cilmostim
2343:Agonists:
2320:Namilumab
2277:Agonists:
2221:Agonists:
2110:Agonists:
2073:Chemokine
1127:apoptosis
1115:monocytes
996:NP_035744
975:NP_003800
949:NM_011614
928:NM_003809
758:Orthologs
137:GeneCards
2996:ZM-39923
2913:NSC-7908
2878:AZD-1480
2769:instead.
2749:instead.
2729:instead.
2705:instead.
2623:MEDI-545
2397:instead.
2325:Otilimab
2128:CNTO-530
2084:instead.
2023:15140220
1988:15056843
1953:14961121
1902:12496418
1867:12445828
1838:12421989
1803:11839778
1774:11777967
1739:11728344
1717:Immunity
1704:38403545
1696:11094155
1653:10706675
1618:10085077
1583:15353286
1548:12787562
1509:26924336
1460:24636536
1417:16325585
1359:14953579
1221:–
1200:–
1171:fibrosis
1155:fibrosis
1099:cytokine
1093:Function
1044:Wikidata
737:Sources:
617:membrane
3129:protein
2938:SD-1008
2113:ARA-290
1944:1618873
1923:Bibcode
1674:Bibcode
1500:4949530
1425:2660454
1351:9560343
1329:Bibcode
1302:9405449
1223:Ensembl
1202:Ensembl
1084:TNFSF12
1080:protein
870:UniProt
825:Ensembl
764:Species
743:QuickGO
367:pattern
225:17p13.1
141:TNFSF12
125:1196259
100:TNFSF12
93:Aliases
22:TNFSF12
3032:Others
2898:CYT387
2888:CHZ868
2777:Others
2533:IFNA21
2529:IFNA17
2525:IFNA16
2521:IFNA14
2517:IFNA13
2513:IFNA10
2021:
1986:
1951:
1941:
1915:Nature
1900:
1865:
1836:
1801:
1772:
1737:
1702:
1694:
1651:
1616:
1581:
1546:
1507:
1497:
1458:
1423:
1415:
1357:
1349:
1300:
1107:TWEAKR
1030:search
1028:PubMed
903:O54907
884:O43508
780:Entrez
538:BioGPS
117:602695
3127:This
2572:IFNB3
2568:IFNB1
2509:IFNA8
2505:IFNA7
2501:IFNA6
2497:IFNA5
2493:IFNA4
2489:IFNA2
2485:IFNA1
1700:S2CID
1421:S2CID
1355:S2CID
1173:, to
1163:liver
813:21944
773:Mouse
768:Human
739:Amigo
488:ankle
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
3133:stub
3011:TYK2
2953:JAK3
2865:JAK2
2802:JAK1
2767:here
2765:See
2747:here
2745:See
2738:TGFβ
2727:here
2725:See
2703:here
2395:here
2393:See
2082:here
2080:See
2019:PMID
1984:PMID
1949:PMID
1898:PMID
1863:PMID
1834:PMID
1799:PMID
1770:PMID
1735:PMID
1692:PMID
1649:PMID
1614:PMID
1579:PMID
1544:PMID
1505:PMID
1456:PMID
1413:PMID
1395:Cell
1347:PMID
1298:PMID
1157:and
1121:and
1087:gene
794:8742
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
133:7979
113:OMIM
70:4HT1
51:RCSB
48:PDBe
2785:JAK
2758:TNF
2093:CSF
2009:doi
2005:122
1974:doi
1939:PMC
1931:doi
1919:427
1888:doi
1884:170
1855:doi
1851:299
1824:doi
1820:169
1791:doi
1787:115
1760:doi
1756:168
1725:doi
1682:doi
1670:485
1639:doi
1635:164
1604:doi
1600:274
1569:doi
1536:doi
1495:PMC
1487:doi
1483:239
1448:doi
1403:doi
1399:123
1337:doi
1288:doi
1284:272
546:n/a
484:lip
343:End
242:End
145:OMA
121:MGI
41:PDB
3178::
2570:,
2531:,
2527:,
2523:,
2519:,
2515:,
2511:,
2507:,
2503:,
2499:,
2495:,
2491:,
2487:,
2017:.
2003:.
1999:.
1982:.
1970:68
1968:.
1964:.
1947:.
1937:.
1929:.
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1878:.
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1177:.
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349:bp
336:bp
248:bp
235:bp
143:;
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135:;
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127:;
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119:;
115::
3164:e
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3150:v
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147::
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