262:
859:"Induction of latency-associated peptide (transforming growth factor-β1) expression on CD4+ T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-α production in a transforming growth factor-β-dependent manner"
351:
3 cells were described as 50 times more potent immune suppressors than the classical regulatory FOXP3 T lymphocytes and their functions was mainly mediated by secretion of suppressive cytokines.
133:. TGF-beta promotes the class switch to low concentrations of IgA which is noninflammatory. IgA does not usually activate the complement system and is not involved with
392:
3 participate in the regulation of the immune response via mechanisms independent on cell-to-cell contact. Secretion of anti-inflammatory cytokine TGF-β by T
381:
3 cells can be activated by TCR stimulation after the recognition of an antigen or induced from CD4+ T lymphocytes by TGF-β in the presence of IL-10 and
113:
to enhance or inhibit their activity. This is of particular importance in the gut as this is where the highest load of foreign material, food, is present. T
914:
Scurr, M.; Ladell, K.; Besneux, M.; Christian, A.; Hockey, T.; Smart, K.; Bridgeman, H.; Hargest, R.; Phillips, S.; Davies, M.; Price, D. (March 2014).
916:"Highly prevalent colorectal cancer-infiltrating LAP + Foxp3 − T cells exhibit more potent immunosuppressive activity than Foxp3 + regulatory T cells"
75:
1104:
1323:
761:"Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3"
1359:
230:
50:
1282:
1404:
1374:
1354:
1392:
1387:
1227:
857:
Boswell, Sandra; Sharif, Shayan; Alisa, Akeel; Pereira, Stephen P.; Williams, Roger; Behboudi, Shahriar (2011-03-23).
87:
1097:
636:
Sakaguchi, S; Ono, M; Setoguchi, R; Yagi, H; Hori, S; Fehervari, Z; Shimizu, J; Takahashi, T; Nomura, T (2006).
1190:
1431:
1274:
463:
Gol-Ara, Maryam; Jadidi-Niaragh, Farhad; Sadria, Reza; Azizi, Gholamreza; Mirshafiey, Abbas (2012-10-24).
91:
1313:
1290:
1266:
339:
3 cells produce vast amounts of TGF-β and to a lesser degree also the anti-inflammatory cytokine
1337:
1154:
1090:
294:
1346:
1185:
465:"The Role of Different Subsets of Regulatory T Cells in Immunopathogenesis of Rheumatoid Arthritis"
358:
32:
971:
Andrews, Lawrence P.; Marciscano, Ariel E.; Drake, Charles G.; Vignali, Dario A. A. (March 2017).
297:
FOXP3. There is a lack of specific transcription factor for full and reliable recognition of the T
1318:
1305:
667:
308:
is presented on cell surface shortly after activation. The presence of CD69 is not specific for T
241: cells through CTLA-4 mediated signaling may stimulate the differentiation of both induced T
638:"Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease"
1369:
1250:
1169:
1149:
1069:
1051:
1010:
992:
953:
935:
896:
878:
839:
790:
741:
706:
659:
618:
600:
558:
540:
496:
344:
282:
161:
43:
28:
737:
1462:
1242:
1218:
1059:
1041:
1000:
984:
943:
927:
886:
870:
829:
821:
780:
772:
733:
698:
649:
608:
592:
548:
530:
486:
476:
441:
408:
responses in the body. TGF-β is a crucial cytokine for maintaining the naturally occurring T
357:
acts as a negative regulator of T cell activation and function and can also be expressed on
317:
118:
95:
1064:
1029:
1005:
972:
948:
915:
891:
858:
834:
809:
785:
760:
759:
Chen, W; Jin, W; Hardegen, N; Lei, KJ; Li, L; Marinos, N; McGrady, G; Wahl, SM (2003).
613:
580:
579:
Weiner, Howard L.; da Cunha, Andre Pires; Quintana, Francisco; Wu, Henry (2011-04-13).
553:
518:
491:
464:
340:
222:
195:
130:
102:
71:
324:) noncovalently bounds TGF-β and can be expressed by many cells of the immune system.
1456:
1441:
1423:
1261:
1223:
1144:
874:
654:
637:
596:
413:
382:
191:
173:
671:
519:"Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells"
1256:
1159:
405:
401:
366:
229:
3 cells in the intestine. Additionally, since TGF-β production was induced by
134:
1436:
1139:
1134:
397:
225:, which has been considered to be the source of cytokines for the induction of T
79:
702:
1113:
535:
313:
1055:
1046:
996:
939:
882:
604:
544:
1409:
1364:
1212:
221:
3 cells. It was previously shown that TGF-β was produced by intestinal
106:
1073:
1014:
957:
900:
843:
794:
745:
710:
663:
622:
562:
500:
825:
481:
1178:
1129:
776:
187:
178:
157:
126:
122:
46:
1030:"The Tolerogenic Function of Regulatory T Cells in Pregnancy and Cancer"
1397:
931:
110:
35:
988:
261:
1200:
1164:
1121:
437:
205:
3 cells are a different lineage from naturally arising CD25CD4 T
24:
686:
233:(CTLA-4), which is constitutively expressed on naturally arising T
63:
1028:
Jørgensen, Nanna; Persson, Gry; Hviid, Thomas
Vauvert F. (2019).
332:
278:
83:
1086:
1082:
365:
3. Because of its structural similarity to CD4, LAG3 can bind
125:. They mediate this non-inflammatory environment by secreting
60:
117:
3 cells are involved in mucosal immunity and protecting
31:
functions, that can be induced by administration of foreign
217: cells because of the lack of a specific marker for T
70:
3 cells were first described in research focusing on
105:
generally is to mediate the immune response by secreting
237: cells, it is possible that TGF-β production from T
436:
2 cells by secretion of TGF-β and provide help to
810:"CD69: From Activation Marker to Metabolic Gatekeeper"
687:"Phenotype and function of intestinal dendritic cells"
1422:
1345:
1336:
1304:
1199:
1120:
517:Chien, Chien-Hui; Chiang, Bor-Luen (2017-11-18).
42:3 cells act mainly through the secretion of
59:3 have been described both in mice and human as
973:"LAG3 (CD223) as a cancer immunotherapy target"
281:FOXP3-LAP cells. Unlike the well characterised
724:Iwasaki, A (2007). "Mucosal dendritic cells".
209: cells, but it is still unclear whether T
1098:
312:3 cells, since it is expressed on other
8:
808:D, Cibrián; F, Sánchez-Madrid (June 2017).
160:requirements for their growth from CD25CD4
1342:
1205:
1105:
1091:
1083:
320:resident. The latency-associated peptide (
1063:
1045:
1004:
947:
890:
833:
784:
653:
612:
552:
534:
490:
480:
428:3 cells can also directly suppress T
277:3 cells are characterised as CD4CD25
738:10.1146/annurev.immunol.25.022106.141634
260:
121:in the gut from non-pathogenic non-self
452:
257:3 phenotype and secreted molecules
213:3 cells are the same as induced T
7:
574:
572:
512:
510:
458:
456:
400:in the gut and suppress exaggerated
76:experimental autoimmune encephalitis
1324:Mucosal associated invariant T cell
685:Johansson, C; Kelsall, BL (2005).
90:cells, that can be induced in the
14:
373:Activation and effector functions
49:transforming growth factor beta (
1360:Lymphokine-activated killer cell
875:10.1111/j.1365-2567.2011.03425.x
655:10.1111/j.0105-2896.2006.00427.x
597:10.1111/j.1600-065x.2011.01017.x
231:cytotoxic T-lymphocyte antigen 4
396:3 cells helps to maintain
814:European Journal of Immunology
1:
523:Journal of Biomedical Science
1405:Type 3 innate lymphoid cells
1393:Type 2 innate lymphoid cells
1388:Type 1 innate lymphoid cells
1375:Uterine natural killer cells
1355:Cytokine-induced killer cell
333:lymphocyte activation gene-3
293:3 cells do not express
186:3 cells is enhanced by
156:3 cells have different
424:2 immune functions. T
412: cells, that suppress
168:. The survival of CD25CD4 T
1479:
703:10.1016/j.smim.2005.05.010
316:, mainly subsets that are
82:and later described as CD4
66:regulatory T cells. T
1383:
1208:
536:10.1186/s12929-017-0391-3
361:and other T cells, than T
331:3 cells can express
1047:10.3389/fimmu.2019.00911
304:Type II-lectin receptor
301:3 cell population.
172:cells is dependent upon
94:by oral antigen through
27:with immunoregulary and
1432:Hematopoietic stem cell
1191:Lymphoplasmacytoid cell
1034:Frontiers in Immunology
201:Findings suggest that T
367:MHC class II molecules
270:
1338:Innate lymphoid cells
1314:Natural killer T cell
977:Immunological Reviews
826:10.1002/eji.201646837
585:Immunological Reviews
264:
109:and interacting with
777:10.1084/jem.20030152
295:transcription factor
182:differentiation of T
1306:Innate-like T cells
1186:Transitional B cell
482:10.1155/2012/805875
269:3 ) phenotype.
23:3) are a subset of
932:10.1038/mi.2013.62
920:Mucosal Immunology
271:
265:T helper 3 cell (T
98:(TCR) signalling.
1450:
1449:
1418:
1417:
1332:
1331:
989:10.1111/imr.12519
771:(12): 1875–1886.
345:colorectal cancer
245: cells and T
44:anti-inflammatory
29:immunosuppressive
1470:
1370:Adaptive NK cell
1343:
1206:
1107:
1100:
1093:
1084:
1078:
1077:
1067:
1049:
1025:
1019:
1018:
1008:
968:
962:
961:
951:
911:
905:
904:
894:
854:
848:
847:
837:
805:
799:
798:
788:
756:
750:
749:
726:Annu Rev Immunol
721:
715:
714:
682:
676:
675:
657:
633:
627:
626:
616:
581:"Oral tolerance"
576:
567:
566:
556:
538:
514:
505:
504:
494:
484:
460:
289: ) cells, T
119:mucosal surfaces
101:The function of
17:T helper 3 cells
1478:
1477:
1473:
1472:
1471:
1469:
1468:
1467:
1453:
1452:
1451:
1446:
1414:
1379:
1328:
1300:
1294:
1286:
1278:
1270:
1246:
1238:
1231:
1195:
1173:
1116:
1111:
1081:
1027:
1026:
1022:
970:
969:
965:
913:
912:
908:
856:
855:
851:
807:
806:
802:
758:
757:
753:
723:
722:
718:
684:
683:
679:
635:
634:
630:
578:
577:
570:
516:
515:
508:
462:
461:
454:
450:
435:
431:
427:
423:
417:
411:
395:
391:
380:
375:
364:
350:
338:
330:
311:
300:
292:
288:
276:
268:
259:
256:
248:
244:
240:
236:
228:
223:dendritic cells
220:
216:
212:
208:
204:
185:
171:
165:
155:
148:
144:
140:
116:
96:T cell receptor
69:
58:
41:
22:
12:
11:
5:
1476:
1474:
1466:
1465:
1455:
1454:
1448:
1447:
1445:
1444:
1439:
1434:
1428:
1426:
1420:
1419:
1416:
1415:
1413:
1412:
1407:
1402:
1401:
1400:
1390:
1384:
1381:
1380:
1378:
1377:
1372:
1367:
1362:
1357:
1351:
1349:
1340:
1334:
1333:
1330:
1329:
1327:
1326:
1321:
1316:
1310:
1308:
1302:
1301:
1299:
1298:
1297:
1296:
1292:
1288:
1284:
1280:
1276:
1272:
1268:
1259:
1254:
1244:
1236:
1229:
1221:
1215:
1209:
1203:
1197:
1196:
1194:
1193:
1188:
1183:
1182:
1181:
1171:
1167:
1162:
1157:
1152:
1147:
1142:
1137:
1132:
1126:
1124:
1118:
1117:
1112:
1110:
1109:
1102:
1095:
1087:
1080:
1079:
1020:
963:
926:(2): 428–439.
906:
869:(3): 278–287.
849:
820:(6): 946–953.
800:
751:
716:
697:(4): 284–294.
677:
628:
591:(1): 241–259.
568:
506:
451:
449:
446:
433:
429:
425:
421:
415:
409:
393:
389:
378:
374:
371:
362:
348:
341:interleukin 10
336:
328:
309:
298:
290:
286:
274:
266:
258:
254:
251:
249:3 cells.
246:
242:
238:
234:
226:
218:
214:
210:
206:
202:
183:
176:(IL-2), while
169:
163:
153:
149:2 cells.
146:
142:
138:
114:
103:T helper cells
72:oral tolerance
67:
56:
39:
20:
13:
10:
9:
6:
4:
3:
2:
1475:
1464:
1461:
1460:
1458:
1443:
1442:Prolymphocyte
1440:
1438:
1435:
1433:
1430:
1429:
1427:
1425:
1424:Lymphopoiesis
1421:
1411:
1408:
1406:
1403:
1399:
1396:
1395:
1394:
1391:
1389:
1386:
1385:
1382:
1376:
1373:
1371:
1368:
1366:
1363:
1361:
1358:
1356:
1353:
1352:
1350:
1348:
1344:
1341:
1339:
1335:
1325:
1322:
1320:
1317:
1315:
1312:
1311:
1309:
1307:
1303:
1295:
1289:
1287:
1281:
1279:
1273:
1271:
1265:
1264:
1263:
1262:Memory T cell
1260:
1258:
1255:
1252:
1248:
1240:
1232:
1225:
1222:
1220:
1219:Cytotoxic CD8
1216:
1214:
1211:
1210:
1207:
1204:
1202:
1198:
1192:
1189:
1187:
1184:
1180:
1177:
1176:
1175:
1168:
1166:
1163:
1161:
1158:
1156:
1155:Marginal zone
1153:
1151:
1148:
1146:
1143:
1141:
1138:
1136:
1133:
1131:
1128:
1127:
1125:
1123:
1119:
1115:
1108:
1103:
1101:
1096:
1094:
1089:
1088:
1085:
1075:
1071:
1066:
1061:
1057:
1053:
1048:
1043:
1039:
1035:
1031:
1024:
1021:
1016:
1012:
1007:
1002:
998:
994:
990:
986:
982:
978:
974:
967:
964:
959:
955:
950:
945:
941:
937:
933:
929:
925:
921:
917:
910:
907:
902:
898:
893:
888:
884:
880:
876:
872:
868:
864:
860:
853:
850:
845:
841:
836:
831:
827:
823:
819:
815:
811:
804:
801:
796:
792:
787:
782:
778:
774:
770:
766:
762:
755:
752:
747:
743:
739:
735:
731:
727:
720:
717:
712:
708:
704:
700:
696:
692:
691:Semin Immunol
688:
681:
678:
673:
669:
665:
661:
656:
651:
647:
643:
639:
632:
629:
624:
620:
615:
610:
606:
602:
598:
594:
590:
586:
582:
575:
573:
569:
564:
560:
555:
550:
546:
542:
537:
532:
528:
524:
520:
513:
511:
507:
502:
498:
493:
488:
483:
478:
474:
470:
466:
459:
457:
453:
447:
445:
443:
439:
419:
407:
403:
399:
386:
384:
372:
370:
368:
360:
356:
352:
346:
342:
334:
325:
323:
319:
315:
307:
302:
296:
284:
280:
263:
252:
250:
232:
224:
199:
197:
193:
189:
181:
180:
175:
174:interleukin 2
167:
159:
150:
136:
132:
128:
124:
120:
112:
108:
104:
99:
97:
93:
89:
85:
81:
77:
73:
65:
62:
54:
53:
48:
45:
37:
34:
30:
26:
25:T lymphocytes
18:
1234:
1037:
1033:
1023:
983:(1): 80–96.
980:
976:
966:
923:
919:
909:
866:
862:
852:
817:
813:
803:
768:
764:
754:
729:
725:
719:
694:
690:
680:
645:
641:
631:
588:
584:
526:
522:
472:
468:
432:1 and T
402:inflammatory
387:
376:
354:
353:
343:(IL-10). In
326:
321:
305:
303:
283:T regulatory
272:
200:
177:
151:
141:3 inhibits T
135:phagocytosis
100:
51:
16:
15:
1437:Lymphoblast
1135:Plasmablast
1114:Lymphocytes
732:: 381–418.
642:Immunol Rev
444:secretion.
398:homeostasis
385:cytokines.
327:In tumors T
314:lymphocytes
166: cells
80:mouse model
1251:Regulatory
1224:Helper CD4
1150:Follicular
863:Immunology
475:: 805875.
448:References
406:autoimmune
1410:LTi cells
1365:Null cell
1213:Thymocyte
1056:1664-3224
997:0105-2896
940:1935-3456
883:0019-2805
765:J Exp Med
605:0105-2896
545:1423-0127
529:(1): 86.
469:Arthritis
335:(LAG3). T
107:cytokines
1457:Category
1398:Nuocytes
1347:NK cells
1179:B10 cell
1074:31134056
1015:28258692
958:24064667
901:21426338
844:28475283
795:14676299
746:17378762
711:15978836
672:27536160
664:16903903
648:: 8–27.
623:21488901
563:29151021
501:23133752
440:towards
359:NK cells
179:in vitro
158:cytokine
123:antigens
47:cytokine
1463:T cells
1201:T cells
1130:B1 cell
1122:B cells
1065:6517506
1040:: 911.
1006:5338468
949:3931584
892:3112337
835:6485631
786:2194145
614:3296283
554:5694621
492:3486158
438:B cells
145:1 and T
111:B-cells
74:in the
36:antigen
1145:Memory
1140:Plasma
1072:
1062:
1054:
1013:
1003:
995:
956:
946:
938:
899:
889:
881:
842:
832:
793:
783:
744:
709:
670:
662:
621:
611:
603:
561:
551:
543:
499:
489:
318:tissue
194:, and
78:(EAE)
1257:Naïve
1165:Pre-B
1160:Naïve
668:S2CID
420:and T
196:IL-10
188:TGF-β
131:IL-10
127:TGF-β
86:FOXP3
64:FOXP3
52:TGF-β
1217:αβ (
1174:cell
1070:PMID
1052:ISSN
1011:PMID
993:ISSN
954:PMID
936:ISSN
897:PMID
879:ISSN
840:PMID
791:PMID
742:PMID
707:PMID
660:PMID
619:PMID
601:ISSN
559:PMID
541:ISSN
497:PMID
473:2012
404:and
383:IL-4
355:LAG3
306:CD69
279:CD69
192:IL-4
129:and
84:CD25
55:). T
33:oral
1172:reg
1060:PMC
1042:doi
1001:PMC
985:doi
981:276
944:PMC
928:doi
887:PMC
871:doi
867:133
830:PMC
822:doi
781:PMC
773:doi
769:198
734:doi
699:doi
650:doi
646:212
609:PMC
593:doi
589:241
549:PMC
531:doi
487:PMC
477:doi
442:IgA
410:reg
322:LAP
287:reg
243:reg
239:reg
235:reg
215:reg
207:reg
170:reg
164:reg
137:. T
92:gut
88:LAP
61:CD4
38:. T
1459::
1319:γδ
1293:VM
1285:RM
1277:EM
1269:CM
1249:/
1247:17
1241:/
1233:/
1230:FH
1226:/
1068:.
1058:.
1050:.
1038:10
1036:.
1032:.
1009:.
999:.
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