68:
years, but immune system reactions (or something else) killed them not long after the transplant; the success rate was 0 in effect. The
Alberta foks seem to have found a way around the problem. Getting it to clinical practice will not, it seems, be easy. Perhaps in a few years? Or perhaps figuring out how to get stem cells to produce beta cells (your very own new ones) might be an earlier answer. On the other hand, the politics surrounding stem cell research (at least in the US) may put a hold on that for a very long time.
657:(diabetes mellitus type 2, the more common form). The former requires insulin injections, otherwise death will occur within a month; thus insulin dependant for survival. The latter is generally managed with decreased carbohydrate intake and oral medications; it is only treated with insulin if the dietary and tablet(s) recommendations are ineffective. However, for type 2, lack of insulin treatment does not result in death in less than 1 month; insulin is a treatment option, although still commonly used.
530:
preclude extra weight, with non-Western foods, little exercise, and limited calories, it would be a candidate. Presumably the environmental triggers for Type I (assorted virus infections some carried by insects, at least one rat poison, ...) would be more or less uniform in distribution, especially in areas without hard freezing winters. Pima
Indians on the US side of the US-Mexican border have fantastically high rates of Type 2. Those with essentially the same heredity on the Mexican side have
544:
parts of the Arctic now that it is turning into a monster bog as the permafrost loses its perma and as the trees to the south are being ravaged by insects and other parasites they've never encountered as they used to die off during a cold sub-Arctic winter if they were unfortunate enough to be blown or other wise transported north. Been getting closer and closer to an environmental disaster, if not already, for about a decade. Satellite photography is definitive. And so on and so on.
730:
247:
many people have, and we are beginning to refer to young people having "type 1.5" or "type 1+2" or "monogenic diabetes"-- I can explain what these are if you are interested). The condition described in your reference does not even involve high blood sugars so it seems silly to refer to it as any type of diabetes. The subject of intracerebral insulin is fascinating, but it isn't diabetes.
863:
cases). This is more common(?) in those that only show diabetic symptoms but do not have a case of diabetes. Some of the sources above seem to hint at that. Instead of a view directed at cow's milk, I suggest a view directed at diabetic symptoms with those that are lactose intollerant and if there is any equality with those that are not lactose intollerant. —
369:
for diabetics and interested others who might not have the vocabulary that this page's editors evidently command, I think it's important to alter the language a bit to make it easier to read. Just my two cents. Also, I'm taking out that "frank" word mentioned above, as I think it's completely unnecessary and maybe just wrong.
196:
The only things I've picked up on so far, are diet, exercise, and whatnot. I see there's no section in the main article. Should there be, or should it be its own article? As for the topic of discussion, I have no background (thankfully) on it. Normally I'd jump right in, but I'll pass on this one.
566:
You realize don't you that type 1 is not evenly distributed. The highest incidences occur in northern temperate climates. Finland has a per capita rate of type 1 that exceeds that of most equatorial countries by more than 10 fold. The rate of type 2 in the general population in the US is approaching
117:
It is clearly an advance, just has turned out a bit disappointing after the initial report of 11 out of 11 recipients off insulin at a year-- no one has been able to replicate that and I think now that nearly all those 11 are back on insulin. The original hope was for a cure, not just a reduction of
673:
Currently the traditional GP and internist management of type 2, sometimes caricatured as "treat to failure", leaves the majority of insulin-deficient people with type 2 chronically hyperglycemic by presenting insulin as a "patient option" differently than we do for type 1. The sentences seemed too
543:
Poverty (but not too much), malnuitrition (but not too much), perhaps enough of one or the other to prevent much exercise, ... would probably do the trick. Too many countries more or less fit the bill. Much of the Horn of Africa is a candidate, the Sahel where the Sahara is advancing steadily, some
308:
Some of the phrasing in this page leads me to wonder if parts of it have been copied wholesale from other sources ("These symptoms may also manifest in Type 2 diabetes in patients who present with frank poorly controlled diabetes."?), and what those sources might be. Now, if *I* can write "believe
264:
I'd never heard of Type 3 (other than the article mentioned in the first comment) or Type 4 diabetes. The terms do not appear in the WHO article (reference 2 in the main article) or in the index to the
Textbook of Diabetes (Ed. Pickup and Williams, 2003, 3rd edition). After a quick Google ( "Type
665:
Death does not always occur within a month if insulin is omitted in type 1. Although uncommon, there are enough circumstances when this does not occur that we should not make such a flat claim. The most notorious example is the honeymoon period. A hedged statement or insertion of "nearly always in
368:
I too think parts of this article read too heavily; for example, the cures section. I consider myself an educated and literate person, and I get terribly frustrated reading the terminology and clumsy language in this article. Considering that this page could viably serve as important information
67:
Actually, there is another currently available (though so far only experimental) 'cure' for Type 1. A few years ago, researchers in
Alberta Canada managed to transplant beta cells into about 10 Type 1 patients. Of those, 8 (if memory serves) succeeded. There had been sporadic attempts to do so for
669:
It is difficult to make simple generalizations about type 2, but a large proportion of people who develop type 2 have enough of an insulin deficiency to require insulin injections. Sometimes insulin sufficiency can revive with a combination of normoglycemia and improvement in insulin sensitivity;
486:
The article states that
Diabetes type 2 is far more common than type 1. As type two is often caused by diet rich in sugars and fats and other lifestyle factors, would it not be important to say that this were more common in MEDCs where this diet is more easily available (like America), and not so
246:
I just saw this article reviewed in a journal. Calling it type 3 is not likely to catch on. We already have dozens of types of diabetes beyond 1 & 2 and even the broad definitions of 1 & 2 feel like they are in flux again (e.g., it seems harder than it did in the 1980s to decide what type
181:
Successful transplants of whole pancreases and islets for non-autoimmune types of diabetes (like pancreatectomy for pancreatitis) have been successful many times and are done at many centers in North
America. This was news only because it was a smaller dose of islets from a living donor. The news
862:
I'm not an expert on this; however, from experience with diabetics I have found that cow's milk is regarded as to be avoided. It is not cow's milk that directly causes the diabetes, but it changes the environment inside the human body to allow for such symptoms as diabetes (and other non-related
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Actually, it would be a good thing in respect of Type II to note in this (or some sub article) just what is now thought to be the connection with fat tissue (self-inflammation, if I understand correctly), what it is in "Western diet" which pushes toward Type 2, and what it is about exercise that
223:
Would someone care to provide a cite on the existance of Type 3 as a bonafide category? The only thing that I can find, is an article dated the 9th of this month discussing the possible need for the lable in connection with an
Insulin issue involving the brain, . Unless a confirming cite can be
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The most intriguing recent hypothesis about the higher risks in northern Europe is that subclinical (i.e., not severe enough to cause rickets) vitamin D deficiency predisposes to autoimmune diseases like diabetes. Your suggestion of increased viral infections in indoor winters or excessive cold
581:
German measles is one of those viruses which can trigger Type 1 in HLA susceptible individuals, and there are several in the (euphonious) Coxsackie family. Or, in the case of
Finland, it might be infections resulting from all that birching when they rush out into the frozen world from the sauna?
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A, Nope, I hadn't realized Type 1 distibution was quite so uneven. I knew about
Finland, of course, but... Perhaps it's the minor infections that result from confinement with others in temperatures not causing frank frostbite? Did Finnish Type 1 rates change as central heating became available?
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I cannot cite reliable statistics for any such country. But I note that Type 2 is strongly correlated with weight (especially visceral weight), with "Western diet", lack of exercise, and probably with calorie throughput over time. So if we can find a country in which diets are sparse enough to
272:
Agreed, that is why I finally changed the Type 4 label to be just
Gestational. But how do we handle replacing the Type 3 label? The only thing the variants in that group have in common seems to be that they don't belong anywhere else, and I have never heard of a formal way of referring to them
48:
I received the transplants at the University of Iowa Medical Centers. At that location, they will only consider pancreas transplants (at least to cure diabetes) for patients who already have or will simultaneously receive another transplanted organ (typically a kidney). I understand that other
567:
1 in 20 in some states, while the rate of type 1 in the US is about 1 in 300 and the rate in some equatorial countries a fraction of that. You are going to have a lot of difficulty finding a country with a rate of type 1 above type 2. Hence my challenge above.
322:
That's because this article is being edited by laypeople and MDs at the same time. When Alteripse, myself and other docs write, we may gravitate towards medical jargon. I don't think anything on this page is from other sources - it's been edited too heavily.
157:
Beta cells by themselves tend to behave differently from those in their natural islet environment - they appear to need the companionship of their 'islet-mates' in order to release insulin properly, see page 4 (of 10) in Stem Cells and Diabetes, Chapter 7
167:
Only one successful (to my knowledge) live-donor islet transplant has been performed (it involved extracting islets from a section of a mother's pancreas which were then infused into her daughter who had developed diabetes after pancreatitis), more at:
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helps. I personally suspect all that high fructose corn syrup, as fructose is not under the same controls as is glucose (again as I understand it), and couch potato culture with a gazillion cable TV channels, and even more on the Internet.
294:). in their document, they didn't specifically create and label a type 3 category - but they did acknowledge that there were a whole host of clinical entities that didn't fit into types 1 and 2. but you are right - no doctors use it.
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I agree with Alteripse's version, although there could be some emphasis on the fact that type 1 diabetics are likely to deteriorate rapidly without treatment (cue to teenager stopping her insulin due to IV drug use jokes by peers).
280:
Put a sentence in that says: "One classification system used "type 3" to designate all other miscellaneous forms of diabetes not easily recognized as type 1 or 2 or gestational." And then don't even use the term. No doctors use it.
105:"The HbA(1c) (A1C) level was well controlled in those off insulin (6.4% ) and in those back on insulin but C-peptide positive (6.7% ) and higher in those who lost all graft function (9.0% ) (P < 0.05)." Sounds good to me.
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is not affected directly by glucose levels; however, in the text, it says that 'rising levels of glucose increase insulin production'. I assume that the text should read 'rising levels of glucose stimulate insulin release'.
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that I discern" on a talk page, clearly someone else can write "who present with frank poorly controlled diabetes"... but there seems a thread of that sort of uncommonly precise medical language woven through the article.
38:
This has effectively cured my diabetes. I take no medication to control my blood sugar (neither insulin nor oral medications used to control Type II diabetes). My blood sugar levels are consistantly good (i.e., normal).
256:
I'm still pretty undecided on how to handle the Type 3 label, but unless someone can come with a justifying reference for the Type 4 label, I intend to get rid of it after the end of the month. And just refer to it as
670:
often it cannot. There is much evidence that early use of insulin can promote recovery of exhausted beta cells more effectively than ineffective use of oral medications, and this course is often recommended.
101:
Looking just at the abstract via that link, it looks better than that - the limiting factor is the supply of Islet cells, and postulating stem cell or other tissue culture provision, that can be ovrcome, in
34:
I have had diabetes for 28 years, and two years ago I was diagnosed with chronic kidney disease, caused by the diabetes. As a result, in July of 2003, I received a double transplant: kidney and pancreas.
265:
4" diabetes ) I found an article about them on a Men's Health page but, to my knowledge, these terms are not in current use by researchers or healthcare professionals. Jo Brodie, Diabetes UK.
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for two reasons: too vague and no historical context. Please tell us what they did and whether it was comparable in importance to the people mentioned. Please tell us when they did it. Thanks
499:
Who says the prevalence of DM2 is so much lower in India? The population of that country is so genetically prone to DM2 that the difference may actually be smaller than you are suggesting.
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42:
While this cure does not eliminate the cumulative damage caused by the 28 years of diabetes, it does prevent any additional damage (and perhaps give the body an opportunity to heal).
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In reading through this piece tonight, I note the uneven style that others have commented on here on the talk page... but I believe that I discern another more fundamental problem.
130:. "Many more patients have now been transplanted with this procedure, including two at UMass. Many but not all of those who received these transplants are now off insulin."
834:
Persaud DR, Barranco-Mendoza A. Bovine serum albumin and insulin-dependent diabetes mellitus; is cow's milk still a possible toxicological causative agent of diabetes?
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presented, that section should probably be excised. Also, I have yet to come across anybody referring to Gestational Diabetes as Type 4 , or Type 'Anything Else'.
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There is no preventative measure for T1 and if a section is to be added it should be made clear that lifestyle improvements can only assist the prevention of T2.
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I think the type 3 and 4 classification somehow evolved from the 1999 WHO consultation on definition, diagnosis and classification of diabetes mellitus (see
137:" on google gets over 28000 hits, and "James Shapiro" AND diabetes returns 11000 hits. Seems like it should be worth a mention, and probably its own page.
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Deterioration once beta cells are exhausted needs only hours. And, as stated, the honeymoon can even be years. I'd stick with the current version!
753:
Absence of breast-feeding is associated with the risk of type 1 diabetes: a case-control study in a population with rapidly increasing incidence
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Bovine serum albumin and insulin-dependent diabetes mellitus; is cow's milk still a possible toxicological causative agent of diabetes?
586:
I was concentrating on Type 2 in the observations above, and got led astray a bit by the pending ecological catastrope. Oh well...
516:
I would be interested to hear of any country in which classic type 1 outnumbers classic type 2. I suspect there is no such place.
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I'm not sure why the cow's milk issue is back, it seems to be part of a larger debate over diet in general. Recent study (2006):
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Got it. I knew there were some doctors involved somewhere; didn't know they were first-hand. *Very* nice work, overall, BTW.
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Lack of association between duration of breast-feeding or introduction of cow's milk and development of islet autoimmunity
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I'm indeed not sure what the origin of this classification is. Perhaps searching for 3A, 3B etc may uncover something.
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im not tooo sure if there is a cure for dabetes but i do know that they have cured type one diabetes in labratory rats
31:
Something that seems to be not well known, is that there is a cure to Type I diabetes -- namely, pancreas transplant.
118:
insulin requirement or amelioration of hypoglycemia unawareness. I guess I shouldn't be negative about those things.
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Dr. Lou Bin, Ji lingong, and Mao Tingchea of China also helped discover treatments to maintain insulin stabillity.
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anywhere. Usually the best that I have heard is either Type Wierd or Type 'None of the Above'. Any thoughts? --
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Note that the donor for a pancreas must be a cadaver, as you only have one panceras and you need it to live.
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Also, one's own stem / beta cells would presumably still be subject to the original autoimmune destruction.
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If you think this was too hasty a reversion I am open to compromise or modification on the wording.
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Vaarala O. Is type 1 diabetes a disease of the gut immune system triggered by cow's milk insulin?
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This is only a controversial hypothesis and should be presented as such. Here are some sources:
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Note that this transplant was not experimental, but a standard procedure, covered by insurance.
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transplant centers have differing criteria, and some will transplant a pancreas by itself.
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Nutritional risk predictors of beta cell autoimmunity and type 1 diabetes at a young age
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The diagram caption of the glucose response of a beta pancreatic cell says that insulin
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Is type 1 diabetes a disease of the gut immune system triggered by cow's milk insulin?
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conference will be really deserved if she doesnt need a "booster infusion" in a year.
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Cow's milk and type 1 diabetes: the real debate is about mucosal immune function
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127:"after three years, 89 per cent of patients are still producing insulin"
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Nutritional factors and worldwide incidence of childhood type 1 diabetes
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The most important forms of diabetes are due to decreased production of
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Good to see you're a nightowl as well. Insomniacs of the world, unite!
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Wasmuth HE, Kolb H. Cow's milk and immune-mediated diabetes.
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I removed the following recently inserted sentence: Also,
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http://www.healthfinder.gov/news/newsstory.asp?docID=525217
649:(diabetes mellitus type 1, the first recognized form), or
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exposures is not borne out statistically-- in fact the
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http://www.staff.ncl.ac.uk/philip.home/who_dmc.htm#Tab5
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Hardly a cure-- at best a pretty good treatment for
848:Truswell AS. The A2 milk case: a critical review.
606:of autoimmune vulnerability suggests the opposite.
827:Truswell AS. The A2 milk case: a critical review.
735:The discussion on cow's milk has been moved to
666:established cases" would rectify that sentence.
8:
84:. See 5 yr follow-up report from last July.
388:, is currently nominated to be improved on
301:Yet another style/content complaint... :-)
353:What's first hand, the doctors? *grins*
178:Islet Project Coordinator, Diabetes UK.
392:. Please vote for this article there.--
390:Knowledge:This week's improvement drive
890:Thanks you all who done the website.
7:
429:Yeah, you're right. Care to fix it?
312:Am I the only one who noticed this?
741:Talk:Diabetes mellitus type 1#milk
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661:to the previous version because
852:2005 May;59(5):623-31. Review.
641:I reverted following paragraph
192:Why not an ounce of prevention?
838:2004 May;42(5):707-14. Review.
831:2005 May;59(5):623-31. Review.
758:Recent (2005) review article:
739:. Please add your comments to
1:
845:2000 Nov;59(4):573-9. Review.
713:03:03, 12 December 2005 (UTC)
700:23:55, 11 December 2005 (UTC)
683:23:25, 11 December 2005 (UTC)
611:17:57, 20 November 2005 (UTC)
596:08:25, 20 November 2005 (UTC)
572:07:56, 20 November 2005 (UTC)
559:07:35, 20 November 2005 (UTC)
521:03:19, 20 November 2005 (UTC)
510:21:42, 19 November 2005 (UTC)
494:16:12, 19 November 2005 (UTC)
277:23:15, August 16, 2005 (UTC)
211:03:37, 17 February 2006 (UTC)
187:12:57, 25 November 2005 (UTC)
176:12:46, 25 November 2005 (UTC)
152:13:46, 26 November 2005 (UTC)
147:Go ahead. Turn the link blue.
142:05:10, 26 November 2005 (UTC)
123:01:11, 15 November 2005 (UTC)
113:00:20, 15 November 2005 (UTC)
881:15:46, 28 January 2006 (UTC)
857:14:25, 22 January 2006 (UTC)
809:14:02, 22 January 2006 (UTC)
632:14:15, 6 December 2005 (UTC)
487:much in LEDCs (like India)?
374:02:07, 16 January 2006 (UTC)
202:06:05, 19 January 2006 (UTC)
96:03:02, 7 November 2005 (UTC)
440:13:40, 16 August 2005 (UTC)
286:00:02, 17 August 2005 (UTC)
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674:redolent of that approach.
397:08:38, 9 August 2005 (UTC)
318:23:59, 13 Jun 2005 (UTC)
269:17:31, 13 Aug 2005 (GMT)
261:18:08, 14 Jun 2005 (UTC)
737:Diabetes mellitus type 1
468:Yes, care to elaborate?
363:00:08, 24 Jun 2005 (UTC)
346:19:37, 23 Jun 2005 (UTC)
333:22:42, 14 Jun 2005 (UTC)
252:13:54, 27 May 2005 (UTC)
242:19:34, 10 Apr 2005 (UTC)
82:hypoglycemia unawareness
27:Cure for Type I Diabetes
822:2005;569:151-6. Review.
228:17:13, 27 Mar 2005 PST
77:The Edmonton Protocol.
219:Type 3, Type4 Diabetes
55:-rholton, 18 Nov 2003
768:2004 review article:
651:decreased sensitivity
402:contradiction in page
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384:A related article,
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491:80.2.26.219
139:Flying fish
710:InvictaHOG
408:production
208:Waifwaller
806:JWSchmidt
680:alteripse
629:alteripse
608:alteripse
569:alteripse
518:alteripse
283:alteripse
249:alteripse
197:Thanks!
184:alteripse
149:alteripse
120:alteripse
93:alteripse
462:contribs
423:contribs
267:JoBrodie
199:Supaplex
173:JoBrodie
89:15983207
62:rholton:
854:Andreas
655:insulin
647:insulin
386:Obesity
344:Baylink
316:Baylink
110:Midgley
102:theory.
886:Thanks
413:Waster
394:Fenice
371:Tmkain
16:<
721:milk
696:T@lk
506:T@lk
475:T@lk
456:talk
450:...
436:T@lk
417:talk
360:T@lk
330:T@lk
275:Coro
259:Coro
239:T@lk
226:coro
86:PMID
691:JFW
532:far
501:JFW
470:JFW
431:JFW
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325:JFW
234:JFW
876:as
873:at
870:on
867:Dz
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