547:
has UC where the docs are now talking about surgery after
Remicade gave him serious pneumonia. In what shape, form or linguistically customized way it is added to pass your camel-through-a-needle-eye phrasing is not really of interest in the big picture here. The information on Adacolumns pages seem factually correct and your own findings in Pubmed confirm this - indeed there would be legal penalties if it was false information - so why in the world do you choose to remove rather than edit the information according to your preferences ??? I can assure you that my interest for "advertising" (aka make something known to the public) is fueled by something much stronger than "big pharma" - namely the well-being of my young son and not wishing anyone have to remove their large intestine by surgery unnecessarily. Surgery in my opinion (also based on what I read in discussion forums on the topic) is not such a final solution as the doctors promote it as. Complications and repeat surgery and a (especially for kids) lower quality of life are factors that are hard to avoid.
783:
the page. Anti-nuclear antibodies are for other organ disease correlate with severe disease. There is no particular evidence of anti-food antibodies with the disease. Viruses, are, however implicated in the increase of anti-nuclear antibodies in other diseaeses. Multiple autoimmune conditions may involve ulcerative colitis, and multiple HLA are invovled in these conditions, DR3-DQ2.5 is suppressive. Less genetics does not need more mention, what it needs is less of a genetics section. Epidemiology, unless it pertains to ethnic or geographic differences, is superfluous. Diseases associated with UC can be placed on its own page. I have created one such page for celiac disease. The problem with autoimmune disease, as one gets away from the core pathology, elevated but low frequency associations can be found with many other diseases. Ergo it is not possible to cover all associated disease in a concise main page.
243:
already in the article (and people have let stand). Why remove this? If even one person is able to help speed or augment their recovery then this information is worth leaving in. I'll admit I'd love to see more US studies on it, but as MMSC is something that cannot be 'patented' or packaged up at hundreds of dollars a dose I do not expect to see that happen. I think that is sad, but it is the reality. Please reconsider letting this stand as is.
31:
660:
patients responds to
Adacolumn, depending on the type of disease etc. An advantage is of course that one generally sees no side effects, of disadvantages can be mentioned the high price and extremely limited access to this treatment in Sweden, and further that a lack of objective studies that confirm the treatment effectiveness of Adacolumn.
512:" with a link to a commercial site. This is akin to advertising, hate to break it to you. There is literature on Adacolumn and UC, cite it in your edits and it constitutes a reliable source. Cite a commercial source and it gets removed as advertising. Throw on personal attacks and no one here will take you seriously --
309:
of specific medicines on mice are without correlation to the effect on humans. If nothing else the clinical effect on mice tells us the effect of these medicines are not placebo effects. Thus 2000 years use of such herbal medicines on humans in China and Japan with empirical results are partly confirmed.
651:
Remicade and
Adacolumn are two completely different treatments: Remicade is a medicinal drug with potent anti-inflammatory effects, which is administered directly into the bloodstream. Indications so far has been Rheumatoid Arthritis and severe Crohns disease that do not respond satisfactory on usual
489:
if that came across too harsh. Although I think some latitude should be allowed. The information was verifiable by doing a 2 minute Google search - that was the basis of my irritation. It may be quick for you to delete something, but it costs me time and effort to put it back. Anyway I see Samir has
782:
After reading the page I asked myself the question, what is ulcerative colitis? I read articles on pubmed and they give different descriptions. The literature makes heavy mention of anti-nuclear antibodies, which is mentioned with several other genetically (HLA) linked diseases that are mentioned on
622:
Personally I find it interesting that several diseases with unknown root cause respond to the same medication or treatment. This hints at one or more common causes which the current simulations and knowledge is not yet able to grasp. Particularly Crohns and UC have a significant overlap in terms of
442:
You "have no way of knowing its efficacy" ?? - so please explain to me how europeans and japanese differ signifcantly from the US population ? Or is it just that you don't trust the corresponding authorities in the EU that matches the FDA in the US? The clinical trials and documentation demands are
321:
I for one disagree with labeling removal of colon as a "cure". Especially since I have found information that UC was re-established in a transplanted colon - hinting at a more complex cause-and-effect. BUT whatever I think, I still think it is better to have a multitude of viewpoints, since it will
308:
I once added such information to the article with Pubmed references. References were deleted since they showed only clinical trials on mice and not men. Let me remind you that
Inflixmab/Remicade was "developed from a mouse:human chimerized antibody". One cannot categorically say that clinical trials
285:
Yes, you are right in that rectal steroids or ASA are the recomended treatment, but I believe that this 'vitamin' actually helps to prevent the irrative conditions that lead to the ulceration to begin with. The side effects of long term constant steroid use for people with UC are not without issue.
546:
Hmm, this is where logic fails. You say it should be added but you remove it ?! This does not add up... My intention was to add this information so that patients are aware it exists - I personally did not know it existed until a couple of weeks ago - and it may indeed be of interest to my son who
242:
I again have to disagree. MMSC is a substance that is obtainable over the counter, does not require enemas and either alone or in combination has been show to help people recover from gastric ulcers. It has to be at least as effective (if not more effective) than the Kampo herbal medicine that is
758:
The treatment section has main pages. IMO these subsection should be linked to in an outline and the
Treatment section should be shorted to a summary table with embedded links. Maybe only be one linkout for treatment (KISS - common sense directive) and further subpages should be linked to from the
507:
Well now, some of us have found your "edits" quite interesting: All of your edits are about
Adacolumn and you accuse me of receiving funding from a big-pharma company? You added: "Adacolumn blood cleansing. A total of 10 000 patients have been treated with selective cleaning of the blood in Japan
493:
I must confess I have found some of Samir's editings (read: removals) "interesting" - to the point where I wonder if he receives funding in some form or shape from a "big-pharma" company? It is well known that these are interested in (if the EU is anything to judge that by) limiting any competing
659:
in one elbow and pump the blood through a filter, back via another cannula in the other elbow. In this filter a number of white bloodcells and other harmful elements which are considered to contribute to inflammation in for example Crohns will be trapped. According to my own experience 30-60% of
391:
A total of 10 000 patients have been treated with selective cleaning of the blood in Japan and Europe. This method may offer an option to patients that do not respond to the tradidional medicines or have medicine intolerances. It is a proven method that shows a 50-70 percent remission rate. For
266:
Can we let people know it is generally called "vitamin U". No local health store will likely know what MMSC is. I still believe that there is much more research to the benifit of this than this one line compromise shows. Can you add this reference as well: "Methionine derivatives diminish
167:
Quote: "This double-blind randomised study investigated the role of sulphydryl-containing agents in the management of recurrent attacks of ulcerative colitis. ... These results demonstrate that sulphydryl-containing agents play a key role in the treatment of and protection against ulcerative
99:
It has been too long since I have edited here. My formating skills have lapsed. Can somone fix up the references I've just added for
Vitamin U and the studies on the impact it has been shown to have on reducing, avoiding or healing lesions/ulcers?
205:) evaluating MMSC in UC has certain limitations (primarily because it was done in 1992, and we've learned much on UC since then). First, it was a trial on left sided UC, that we know from the literature is best managed with rectal 5-ASA (
762:
Taking treatment out of view, as I understand Samir put a lot of work into renovating the page, know how difficult that is, having renovated some of my own disasters. But structurally the page is too complex and actually, backwards.
438:
Also be aware that not only readers from the US is using the us/english version of
Knowledge (XXG) for reference - so don't be so arrogant. As long as the geographic area where the treatment is available, I see no problem with this.
508:
and Europe. This method may offer an option to patients that do not respond to the tradidional medicines or have medicine intolerances. It is a proven method that shows a 50-70 percent remission rate. For more information see:
286:
Common side effects of ASA include stomach cramps and pain. Do you have any UC patients? Would you be able to coordinate any type of study? I think you would be honestly very surprised at the effectiveness of this approach.
446:
I know there is currently a significant segregation of
European and US drug testing and approval. But keep in mind that this division has been made primarily for economic and political reasons. Not for medical reasons.
712:
Note that adacolumn is approved in EU and Japen. So I guess it depends if
Knowledge (XXG)'s english version should be reserved for the US point of view (Ongoing Research) or a world point of view (Alternative
796:
Also, there are many factual tidbits that lack references on this page. Maybe if one looked for peer-reviewed material for these references one might be able to clean a few out that were without reference?
401:
Since this is approved in the EU and Japan but not the US, I have no way of knowing its efficacy or much else about it. Should Adacolumn be included in the section on alternative treatments?
280:
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226:) or combination therapy. Secondly, there are questions about the endpoints in the trial cited. I just don't think there's enough evidence for it to be included in the article. Thanks --
618:
Adacolumn can be used for patients with rheumatoid arthritis and ulcerative colitis, potentially also for other similar diseases, where other treatment has not given satisfactory effect.
608:
Adacolumn kan anvendes til pasienter med revmatoid artritt og ulcerøs colitt, eventuelt også ved andre lignende sykdommer, hvor annen behandling ikke har gitt tilfredsstillende effekt.
318:
I wish doctors in general were an ounce more open minded, humble and willing to absorb knowledge outside their "western medicine box" - at least when the true cause of UC is NOT known.
467:– calling me "arrogant" does not help your credibility. I simply asked for discussion on the process and how effective it is in treating UC, because I'm not familiar with it. -
198:
Hi Knoma, I agree that there is basic science evidence on the cytoprotective effects of sulphydryl derivatives in ulcerating disease. However, the one clinical trial (
281:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=13610295&query_hl=9&itool=pubmed_docsum
179:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=1362613&query_hl=10&itool=pubmed_docsum
275:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=4428258&query_hl=9&itool=pubmed_docsum
269:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=8881814&query_hl=9&itool=pubmed_docsum
682:
According to this the Phase I, II, and III testing as well as Filing for Ulcerative Colitis and Crohns are finished and it is now at the approval phase.
655:
Adacolumn first of all is not a medicine, but rather a "medical-technical aid", comparable to kidney dialysis. The treatment consists of inserting one
423:
It is a fact that patients will sometimes cross borders to try specific medical treatments. There is information relating to the USA and Canada on
535:, 17531555. There's literature, and it's a novel idea. We should add it to the article. But not in a spammy way that cites the Otsuka page. --
252:? The important thing to note is that MMSC is not commonly used in management of ulcerative colitis and is an adjunctive therapy at best --
490:
now removed the information I added for Adacolumn under "Ongoging research" under the pretext of it being "written like an advertisment" ??
76:
64:
59:
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title just mentions Crohn's disease but if you check the link you will see it is a resourse for inflammatory bowel diseases. --
325:
Keeping the "Alternatives" section overly sanitized does not promote creative solution thinking or completeness of the subject.
125:
I disagree Samir. Can you look a bit into these links? MMSC (vitamin U) has been shown to be effective in the treatment of UC:
791:
583:
177:
Role of sulphydryl-containing agents in the management of recurrent attacks of ulcerative colitis. A new approach:
164:"Role of sulphydryl-containing agents in the management of recurrent attacks of ulcerative colitis. A new approach."
769:
2. Diagnosis and pathology (or simply pathology) If a whole section on clinical presentation is needed then -: -->
38:
565:
372:- Berberine chloride is another known compound of the Kampo/TCM medicines used for UC. See also some photos on
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The cause of UC may be debated (is it autoimmune, etc); but the symptoms can be significantly lessened by MMSC.
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Clearly the eastern hemisphere of this small planet also is coping with this disease using herbal medicines.
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Perhaps also of interest - one of the identified flavonoids of this traditional medicine - baicalein -
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there is no research there showing any type of clinical research being done for colitis. I did find
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new medicines or treatments that could otherwise erode their established economic foundation.
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347:→ Well, the evidence references were originally included but deleted. (Catch 22) Anyway goto
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Studies show that Vitamin U helps to prevents and can revert ulcer damage in gastric tissues.
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I've removed them. Not UC references, sorry, not related to pathogenesis of the disease --
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Briefly a patient asks for the difference between Remicade (Inflixmab) and Adacolumn.
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Well, here is some actual usage at the National Hospital, Rikshospitalet, Norway.
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361:. 11:45 UTC, 2 November 2006, Tellus, Sol system, MW galaxy, The outskirts. /Rune
800:
This page is not that far away from being a really good page, short of a clean up.
647:
Gastro Enterologist Dag Risberg answers (translated to the best of my abilities):
428:
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Why the removal of references to TCM/Kampo in the alternative treatment section.
46:
If you wish to start a new discussion or revive an old one, please do so on the
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Cite evidence and it will be included. Don't cite evidence and it won't. --
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At the very least it should be included in the "Ongoing research" section.
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sulphide damage to colonocytes--implications for ulcerative colitis."
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which shows it is being clinically trialed for Crohn's disease. ----
424:
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I moved this section from "alternative treatments" for discussion:
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But now the TCM/Kampo references have been completely deleted.
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http://www.otsukapharma.info/medical_professionals/patients.htm
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http://www.otsukapharma.info/medical_professionals/patients.htm
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Example: Ulcerative colitis is associated with other diseases
25:
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So, are we in agreement of adding this info to the main page?
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Some information from another Scandinavian country, Sweden:
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http://www.rikshospitalet.no/view/readavdi.asp?nPubID=3075
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subpage. Clinial presentation of ulcerative colitis.
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you see Ulcerative Colitis mentioned in April 2004.
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This one is is Russian, so may not be as useful: ""
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I added some links to the external and organization
685:Further if you look at the press release archives
521:For example, here's a Sandborn review from 2005:
432:currently in the "recruiting patients" phase.
152:Take another look at these links if you would:
754:Ulcerative Colitis - Too long for a main page
429:http://clinicaltrials.gov/ct/show/NCT00162942
8:
687:http://www.otsuka.com/oapi/OAPIArchives.asp
680:http://www.otsuka.com/oapi/OAPIPipeline.asp
322:stimulate research and breakthrough ideas.
792:ulcerative colitis associated conditions
706:Under what section should it be posted?
376:of clinical trials on rat colons. /Rune
44:Do not edit the contents of this page.
7:
425:http://www.adacolumn.com/index.htm
249:Okay, how is this as a compromise
24:
709:Ongoing Research or Alternative?
443:every bit as strict if not more.
623:the same medicines being used.
29:
279:This one is old and German:
1:
805:02:30, 7 September 2007 (UTC)
652:medicines as e.g. cortisone.
615:Who can get this treatment?
528:. Other relevant articles:
342:00:31, 2 November 2006 (UTC)
291:13:13, 19 October 2006 (UTC)
262:04:27, 19 October 2006 (UTC)
236:17:13, 18 October 2006 (UTC)
117:23:17, 17 October 2006 (UTC)
561:I just did a search on the
365:→ Add also to the evidence
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664:Dag Risberg 27 dec 2005
749:18:12, 19 June 2007 (UTC)
672:17:43, 15 June 2007 (UTC)
630:16:03, 15 June 2007 (UTC)
591:12:42, 11 June 2007 (UTC)
555:23:39, 10 June 2007 (UTC)
450:Please include it again.
540:22:56, 8 June 2007 (UTC)
517:22:34, 7 June 2007 (UTC)
501:22:25, 7 June 2007 (UTC)
481:02:03, 3 June 2007 (UTC)
457:21:34, 29 May 2007 (UTC)
415:06:53, 29 May 2007 (UTC)
701:Reasons for protesting?
605:Hvem får behandlingen?
18:Talk:Ulcerative colitis
392:more information see:
42:of past discussions.
463:Please refrain from
421:Why not include it?
374:this external page
245:User:Knoma_Tsujmai
759:treatment page.
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48:current talk page
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802:Pdeitiker
788:main page
601:Section:
381:Adacolumn
168:colitis."
77:Archive 4
71:Archive 3
65:Archive 2
60:Archive 1
730:The one
586:Contribs
533:17532273
526:16378006
471:Krakatoa
405:Krakatoa
370:10945829
359:11914968
352:10528991
224:15951542
210:10925961
737:Crohnie
657:cannula
571:Crohnie
217:7654892
203:1362613
162:Quoted:
39:archive
431:=: -->
537:Samir
514:Samir
477:Katie
411:Katie
335:Samir
315:Why?
255:Samir
229:Samir
110:Samir
97:Help:
16:<
530:PMID
523:PMID
427:and
367:PMID
356:PMID
349:PMID
338:धर्म
258:धर्म
232:धर्म
221:PMID
214:PMID
207:PMID
200:PMID
113:धर्म
85:MMSC
742:Gal
722:NN
674:NN
632:NN
576:Gal
557:NN
503:NN
459:NN
790::
219:,
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582:/
50:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.