1022:
105:
130:
136:
845:
759:
669:
29:
913:
827:
741:
986:(lncRNA) ranging in length from ~150nt in ciliates to 400-600nt in vertebrates, and 1,300nt in yeast (Alnafakh). Mature human TERC (hTR) is 451nt in length. TERC has extensive secondary structural features over 4 principal conserved domains. The core domain, the largest domain at the 5â end of TERC, contains the CUAAC
1193:. Mature hTR is 451nt in length, but approximately 1/3 of cellular hTR transcripts at steady state have ~10nt genomically encoded 3â tails. The majority of those extended hTR species have additional oligo-A 3â extension. Processing of immature 3â-tailed hTR to mature 451nt hTR can be accomplished by direct 3â-5â
998:, and are the only domains of TERC necessary for in vitro catalytic activity of telomerase. The 3â end of TERC consists of a conserved H/ACA domain, a 2 hairpin structure connected by a single-stranded hinge and bordered on the 3â end by a single-stranded ACA sequence. The H/ACA domain binds
1223:
complex to transcribed H/ACA domains of hTR during transcription promotes termination of transcription. Control of the relative rates of these various competing pathways that activate or inhibit hTR maturation is a crucial element of regulation of overall telomerase activity.
1050:
activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. CCCUAA found near position 50 of the vertebrate TERC sequence acts as the template. Telomerase expression plays a role in cellular
1137:, further increasing telomerase catalytic activity. TERC is ubiquitously expressed, even in cells lacking telomerase activity and TERT expression. As a result, various TERT-independent functional roles of TERC have been proposed. 14
2606:
Soder AI, Hoare SF, Muire S, Balmain A, Parkinson EK, Keith WN (April 1997). "Mapping of the gene for the mouse telomerase RNA component, Terc, to chromosome 3 by fluorescence in situ hybridization and mouse chromosome painting".
2399:
Storti CB, de
Oliveira RA, de Carvalho M, Hasimoto EN, Cataneo DC, Cataneo AJ, et al. (February 2020). "Telomere-associated genes and telomeric lncRNAs are biomarker candidates in lung squamous cell carcinoma (LUSC)".
2833:
Imoto I, Pimkhaokham A, Fukuda Y, Yang ZQ, Shimada Y, Nomura N, et al. (August 2001). "SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus".
2862:
Vulliamy T, Marrone A, Goldman F, Dearlove A, Bessler M, Mason PJ, Dokal I (September 2001). "The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita".
2761:
Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, et al. (September 2000). "Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation".
2313:
Heine B, Hummel M, Demel G, Stein H (June 1998). "Demonstration of constant upregulation of the telomerase RNA component in human gastric carcinomas using in situ hybridization".
2636:
Zhao JQ, Hoare SF, McFarlane R, Muir S, Parkinson EK, Black DM, Keith WN (March 1998). "Cloning and characterization of human and mouse telomerase RNA gene promoter sequences".
143:
2199:
2152:
1133:), which stabilises TERC, increasing telomerase complex formation and overall catalytic activity. The CR7 domain binds TCAB1, which localizes telomerase to
393:
3263:
1034:
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. This repeat does vary across
3827:
3790:
2270:
Kheimar A, Trimpert J, Groenke N, Kaufer BB (March 2019). "Overexpression of cellular telomerase RNA enhances virus-induced cancer formation".
1021:
2993:
Yang Y, Chen Y, Zhang C, Huang H, Weissman SM (July 2002). "Nucleolar localization of hTERT protein is associated with telomerase function".
2175:
2128:
2356:
Gao GC, Yang DW, Liu W (January 2020). "LncRNA TERC alleviates the progression of osteoporosis by absorbing miRNA-217 to upregulate RUNX2".
1353:
4005:
990:
template sequence. Its secondary structure consists of a large loop containing the template sequence, a P1 loop-closing helix, and a P2/P3
2326:
602:
3910:
960:) by telomerase. Telomerase RNAs differ greatly in sequence and structure between vertebrates, ciliates and yeasts, but they share a
3919:
3485:
2673:
Mitchell JR, Wood E, Collins K (December 1999). "A telomerase component is defective in the human disease dyskeratosis congenita".
1371:
Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, et al. (September 1995). "The RNA component of human telomerase".
3972:
3203:
1839:
4015:
2800:"Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase"
1340:
2491:
Marrone A, Dokal I (December 2004). "Dyskeratosis congenita: molecular insights into telomerase function, ageing and cancer".
3832:
1197:
degradation or by an indirect pathway of oligoadenylation by PAPD5, removal of 3â oligo-A tail by the 3â-5â RNA exonuclease
1059:
resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in
129:
104:
3642:
3492:
3256:
1245:
1336:
1312:
1145:
by TERC through RNA-DNA triplex formation-mediated increase of expression. TERC-mediated upregulation of Lin37, Trpg1l,
62:
3633:
3301:
3276:
142:
3762:
3738:
3607:
3439:
3386:
3368:
3280:
3059:"Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro"
1142:
3816:
135:
3249:
1201:, and subsequent 3â-5â exoribonucleolytic degradation. Extended hTR transcripts are also degraded by the RNA
1117:
are sufficient to reconstitute catalytic telomerase activity in vitro. The H/ACA domain of TERC recruits the
4010:
3379:
3310:
1182:
436:
3876:
3807:
1241:
1264:. Upregulation of hTR is widely observed in patients with precancerous cervical phenotype as a result of
3802:
3571:
3241:
3193:
1047:
957:
3198:
1307:. Due to its overexpression in a range of cancer phenotypes, TERC has been investigated as a potential
3849:
3822:
3773:
2871:
2682:
2226:
1741:
1380:
1237:
118:
49:
3579:
1014:
complex. The conserved CR7 domain is also localized at the 3â end of TERC, and contains a 3nt CAB (
983:
968:
2952:"Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells"
3131:
2981:
2895:
2786:
2749:
2706:
2661:
2516:
2479:
2425:
2381:
2338:
2295:
2193:
2146:
1976:
1884:
1522:"Telomerase RNAs of different ciliates have a common secondary structure and a permuted template"
1404:
1289:
1079:
78:
3785:
3602:
3174:
3123:
3088:
3045:
3010:
2973:
2938:
2887:
2850:
2821:
2778:
2741:
2698:
2653:
2624:
2594:
2551:
2508:
2471:
2417:
2373:
2330:
2287:
2252:
2181:
2171:
2134:
2124:
2101:
2028:
1968:
1933:
1876:
1821:
1769:
1693:
1642:
1578:
1543:
1502:
1453:
1396:
1277:
1190:
1068:
1011:
907:
821:
735:
42:
3102:"p53 null mutations are associated with a telomerase negative phenotype in ovarian carcinoma"
2215:"Human papillomavirus and human telomerase RNA component gene in cervical cancer progression"
2072:"Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation"
3742:
3591:
3586:
3478:
3164:
3156:
3113:
3078:
3070:
3035:
3002:
2963:
2928:
2920:
2879:
2842:
2811:
2770:
2731:
2690:
2645:
2616:
2584:
2576:
2541:
2500:
2461:
2409:
2365:
2322:
2279:
2242:
2234:
2091:
2083:
2018:
2010:
1960:
1923:
1915:
1866:
1811:
1803:
1759:
1749:
1683:
1673:
1632:
1624:
1570:
1533:
1492:
1484:
1443:
1435:
1388:
1308:
1212:
895:
809:
719:
222:
153:
3955:
3747:
3621:
3339:
3289:
3272:
1285:
1249:
1202:
1194:
953:
197:
74:
2070:
Chen L, Roake CM, Galati A, Bavasso F, Micheli E, Saggio I, et al. (February 2020).
1219:
to an N2,2,7 trimethylguanosine (TMG) cap, which inhibits hTR maturation. Binding of the
2875:
2686:
2230:
1745:
1424:"Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres"
1384:
3595:
3575:
2247:
2214:
2096:
2071:
2023:
1998:
1928:
1903:
1816:
1791:
1764:
1729:
1688:
1661:
1637:
1612:
1448:
1423:
1257:
1253:
937:
3169:
3144:
3083:
3058:
2816:
2799:
2736:
2719:
2589:
2564:
2466:
2449:
1951:
Shay JW, Wright WE (May 2019). "Telomeres and telomerase: three decades of progress".
1497:
1472:
3999:
3797:
3724:
3334:
3040:
3023:
2933:
2908:
2429:
2385:
1855:"Comparative functional study of the viral telomerase RNA based on natural mutations"
1186:
1083:
3135:
2985:
2909:"Allosteric inhibitors of telomerase: oligonucleotide N3'-->P5' phosphoramidates"
2753:
2520:
2483:
2342:
2299:
1980:
1888:
3936:
2899:
2790:
2710:
2665:
1408:
1304:
1300:
1281:
1056:
967:
structure close to the template sequence. The vertebrate telomerase RNAs have a 3'
215:
95:
1807:
2369:
2087:
1628:
82:
3881:
2413:
1919:
1611:
Roake CM, Chen L, Chakravarthy AL, Ferrell JE, Raffa GD, Artandi SE (May 2019).
1358:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1273:
1178:
1130:
1126:
1060:
1007:
1003:
2238:
1734:
Proceedings of the
National Academy of Sciences of the United States of America
3967:
3941:
3729:
3714:
2504:
2283:
2185:
2138:
1964:
1574:
1561:
Theimer CA, Feigon J (June 2006). "Structure and function of telomerase RNA".
1269:
1134:
1098:
1075:
1064:
1052:
1015:
991:
964:
945:
941:
112:
3905:
3719:
3709:
3232:
3221:
3210:
2565:"Method for determining RNA 3' ends and application to human telomerase RNA"
1754:
1678:
1488:
1439:
1392:
1035:
949:
900:
844:
814:
758:
724:
668:
357:
315:
236:
181:
168:
70:
3178:
3160:
3127:
3100:
Sood AK, Coffin J, Jabbari S, Buller RE, Hendrix MJ, Klingelhutz A (2003).
3092:
3049:
3024:"Differential regulation of telomerase activity by six telomerase subunits"
3014:
3006:
2977:
2942:
2924:
2891:
2854:
2846:
2825:
2782:
2745:
2702:
2649:
2620:
2580:
2555:
2512:
2475:
2421:
2377:
2327:
10.1002/(SICI)1096-9896(199806)185:2<139::AID-PATH79>3.0.CO;2-L
2291:
2256:
2105:
2032:
1972:
1937:
1880:
1871:
1854:
1825:
1773:
1697:
1646:
1582:
1457:
1216:
2968:
2951:
2657:
2628:
2598:
2334:
1547:
1538:
1521:
1506:
1400:
1042:
article for a complete list). The enzyme consists of a protein component (
645:
28:
3982:
3963:
3535:
3526:
3324:
3074:
2907:
Pruzan R, Pongracz K, Gietzen K, Wallweber G, Gryaznov S (January 2002).
2014:
1293:
1233:
1220:
1158:
1157:
pathway, resulting in increased expression and secretion of inflammatory
1154:
1118:
1110:
1039:
999:
987:
634:
3118:
3101:
2546:
2529:
2213:
Liu Y, Fan P, Yang Y, Xu C, Huang Y, Li D, et al. (November 2019).
1999:"TERC promotes cellular inflammatory response independent of telomerase"
53:, DKCA1, PFBMFT2, SCARNA19, TR, TRC3, hTR, Telomerase RNA component, TER
3546:
3521:
3516:
3348:
1613:"Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease"
1260:
and improper regulation of TERC have been associated with a variety of
465:
422:
2530:"Mutations of telomerase complex genes linked to bone marrow failures"
2883:
1261:
1174:
1170:
1146:
1106:
971:
615:
379:
2046:
1660:
Alnafakh RA, Adishesh M, Button L, Saretzki G, Hapangama DK (2019).
483:
479:
2694:
3896:
3891:
3886:
3869:
3864:
3859:
3854:
3842:
3837:
3555:
3550:
3507:
3502:
3497:
2774:
1150:
1020:
961:
728:
1236:
in the TERC genomic locus have been associated with a variety of
870:
784:
694:
3778:
3702:
3697:
3692:
3687:
3682:
3677:
3672:
3667:
3662:
3657:
3652:
3647:
3539:
3469:
3464:
3459:
3454:
3449:
3444:
3432:
3425:
3416:
3411:
3406:
3401:
3396:
3391:
3353:
3329:
3317:
3236:
3225:
3214:
1209:
1208:
The 5â ends of hTR transcripts are also additionally processed.
1198:
1138:
1122:
1114:
1102:
1094:
1043:
995:
888:
865:
802:
779:
712:
689:
66:
3245:
1097:
synthesizes TTAGGG telomeric repeats. Unlike in other RNPs, in
1063:. Studies in mice suggest that telomerase also participates in
1025:
Illustration: hTR and associated proteins of
Telomerase complex
1265:
1090:
994:. The core domain and CR4/CR5 conserved domain associate with
882:
796:
706:
3199:
GeneReviews/NCBI/NIH/UW entry on
Pulmonary Fibrosis, Familial
3145:"Analysis of the structure of human telomerase RNA in vivo"
3022:
Chang JT, Chen YL, Yang HT, Chen CY, Cheng AJ (July 2002).
2358:
European Review for
Medical and Pharmacological Sciences
2047:"OMIM Entry - * 602322 - TELOMERASE RNA COMPONENT; TERC"
1422:
JĂĄdy BE, Richard P, Bertrand E, Kiss T (February 2006).
205:
3194:
2450:"For better or worse? Telomerase inhibition and cancer"
3143:
Antal M, Boros E, Solymosy F, Kiss T (February 2002).
3057:
Gavory G, Farrow M, Balasubramanian S (October 2002).
1303:, with its increased expression arresting the rate of
1997:
Liu H, Yang Y, Ge Y, Liu J, Zhao Y (September 2019).
327:
3954:
3928:
3758:
3629:
3620:
3564:
3364:
3297:
3288:
2835:
906:
894:
881:
876:
864:
856:
851:
837:
820:
808:
795:
790:
778:
770:
765:
751:
734:
718:
705:
700:
688:
680:
675:
661:
580:
561:
537:
518:
2720:"Secondary structure of vertebrate telomerase RNA"
2121:Clinical immunology : principles and practice
1332:
1330:
1328:
2950:Zhang RG, Zhang RP, Wang XW, Xie H (March 2002).
152:
1662:"Telomerase and Telomeres in Endometrial Cancer"
1520:Lingner J, Hendrick LL, Cech TR (August 1994).
1311:. It was found to be an effective biomarker of
1240:. Mutations in TERC have been associated with
3257:
2718:Chen JL, Blasco MA, Greider CW (March 2000).
1280:. Overexpression of TERC is also observed in
1141:containing a TERC binding motif are directly
8:
2563:Zaug AJ, Linger J, Cech TR (February 1996).
1853:Fragnet L, Kut E, Rasschaert D (June 2005).
1840:"Entrez Gene: TERC telomerase RNA component"
1792:"Telomerase RNA is more than a DNA template"
1473:"Ciliate telomerase RNA structural features"
1471:McCormick-Graham M, Romero DP (April 1995).
1109:TERC is structural, rather than acting as a
1902:Wang Y, SuĆĄac L, Feigon J (December 2019).
1728:Zhang Q, Kim NK, Feigon J (December 2011).
1337:GRCh38: Ensembl release 89: ENSG00000277925
1268:infection. Overexpression of TERC enhances
1055:, as it is normally repressed in postnatal
3626:
3294:
3264:
3250:
3242:
2198:: CS1 maint: location missing publisher (
2151:: CS1 maint: location missing publisher (
1908:Cold Spring Harbor Perspectives in Biology
1299:TERC has been implicated as protective in
353:
193:
90:
3168:
3117:
3082:
3039:
2967:
2932:
2815:
2735:
2588:
2545:
2465:
2246:
2095:
2022:
1927:
1870:
1815:
1763:
1753:
1687:
1677:
1636:
1537:
1496:
1447:
1292:, due to TERC-mediated activation of the
952:. TERC serves as a template for telomere
1324:
838:Saccharomyces cerevisiae telomerase RNA
2798:Mitchell JR, Collins K (August 2000).
2191:
2144:
1730:"Architecture of human telomerase RNA"
834:
748:
658:
18:
1992:
1990:
1785:
1783:
1723:
1721:
1719:
1717:
1715:
1713:
1711:
1709:
1707:
1563:Current Opinion in Structural Biology
1089:The core domain of TERC contains the
1018:Localisation) box which binds TCAB1.
157:
116:
111:
7:
2493:Expert Reviews in Molecular Medicine
2402:Experimental and Molecular Pathology
1606:
1604:
1602:
1600:
1598:
1596:
1594:
1592:
2448:de Lange T, Jacks T (August 1999).
2166:Swigris JJ, Brown KK (2018-07-25).
1859:The Journal of Biological Chemistry
1189:located at genomic locus 3q26.2 by
3211:Page for Vertebrate telomerase RNA
1904:"Structural Biology of Telomerase"
1790:Webb CJ, Zakian VA (August 2016).
577:
558:
534:
515:
493:
470:
446:
427:
403:
384:
332:
293:
231:
210:
14:
3920:Control of chromosome duplication
3486:Autonomously replicating sequence
3233:Page for Saccharomyces telomerase
1082:of TERC can also be found in the
1074:of telomere repeats may occur at
3041:10.1046/j.1432-1033.2002.03025.x
3028:European Journal of Biochemistry
2534:Journal of Nippon Medical School
843:
757:
667:
141:
134:
128:
103:
27:
3222:Page for Ciliate telomerase RNA
1113:. The core region of TERC and
316:More reference expression data
1:
3643:DNA polymerase III holoenzyme
3493:Single-strand binding protein
2817:10.1016/S1097-2765(00)00036-8
2737:10.1016/S0092-8674(00)80687-X
2467:10.1016/S0092-8674(00)81955-8
2168:Idiopathic pulmonary fibrosis
1808:10.1080/15476286.2016.1191725
1428:Molecular Biology of the Cell
1246:idiopathic pulmonary fibrosis
126:
3106:Cancer Biology & Therapy
2370:10.26355/eurrev_202001_20029
2088:10.1016/j.celrep.2020.01.004
1629:10.1016/j.molcel.2019.02.033
1313:lung squamous cell carcinoma
948:, the enzyme used to extend
4006:Genes on human chromosome 3
2414:10.1016/j.yexmp.2019.104354
1920:10.1101/cshperspect.a032383
1143:transcriptionally regulated
4032:
3739:Prokaryotic DNA polymerase
3440:Minichromosome maintenance
3387:Origin recognition complex
2995:Experimental Cell Research
2239:10.1038/s41598-019-52195-5
3817:Eukaryotic DNA polymerase
2528:Yamaguchi H (June 2007).
2505:10.1017/S1462399404008671
2284:10.1038/s41388-018-0544-1
1965:10.1038/s41576-019-0099-1
1575:10.1016/j.sbi.2006.05.005
1354:"Human PubMed Reference:"
1173:which are assembled from
842:
756:
666:
662:Vertebrate telomerase RNA
649:
644:
640:
633:
614:
603:Chr 3: 169.76 â 169.77 Mb
597:
584:
565:
554:
541:
522:
511:
500:
496:
477:
473:
464:
453:
449:
434:
430:
421:
410:
406:
391:
387:
378:
363:
356:
352:
340:
335:
326:
313:
300:
296:
243:
234:
204:
196:
192:
175:
162:
125:
102:
93:
89:
60:
57:
47:
40:
35:
26:
21:
16:NcRNA found in eukaryotes
3204:EntrezGene page for TERC
2315:The Journal of Pathology
922:Telomerase RNA component
3380:Pre-replication complex
3311:Pre-replication complex
1953:Nature Reviews Genetics
1755:10.1073/pnas.1100279108
1679:10.3389/fonc.2019.00344
1526:Genes & Development
1440:10.1091/mbc.E05-09-0904
1393:10.1126/science.7544491
1105:is catalytic while the
944:that is a component of
4016:Telomere-related genes
3149:Nucleic Acids Research
3063:Nucleic Acids Research
3007:10.1006/excr.2002.5541
2913:Nucleic Acids Research
2847:10.1006/bbrc.2001.5428
2650:10.1038/sj.onc.1201892
2621:10.1006/geno.1997.4621
2569:Nucleic Acids Research
2119:Rich RR (2018-01-13).
2003:Nucleic Acids Research
1872:10.1074/jbc.M501163200
1477:Nucleic Acids Research
1296:inflammatory pathway.
1242:dyskeratosis congenita
1217:5'-methylguanosine cap
1076:double-stranded breaks
1038:(see the table on the
1026:
752:Ciliate telomerase RNA
259:skeletal muscle tissue
3803:Replication protein A
3572:Origin of replication
2969:10.1038/sj.cr.7290110
1666:Frontiers in Oncology
1539:10.1101/gad.8.16.1984
1489:10.1093/nar/23.7.1091
1276:, and is observed in
1238:degenerative diseases
1228:Clinical Significance
1084:Gallid herpes viruses
1048:reverse transcriptase
1024:
958:reverse transcription
3774:Replication factor C
3161:10.1093/nar/30.4.912
2925:10.1093/nar/30.2.559
2581:10.1093/nar/24.3.532
1093:template from which
119:Chromosome 3 (human)
3119:10.4161/cbt.1.5.167
2876:2001Natur.413..432V
2687:1999Natur.402..551M
2547:10.1272/jnms.74.202
2231:2019NatSR...915926L
2123:(Fifth ed.).
2082:(5): 1358â1372.e5.
1746:2011PNAS..10820325Z
1385:1995Sci...269.1236F
1284:conditions such as
1010:, to form an H/ACA
984:Long non-coding RNA
251:epithelium of colon
3075:10.1093/nar/gkf575
2219:Scientific Reports
2015:10.1093/nar/gkz584
1290:multiple sclerosis
1195:exoribonucleolytic
1181:, hTR is directly
1065:chromosomal repair
1027:
3993:
3992:
3950:
3949:
3786:Flap endonuclease
3616:
3615:
3603:Okazaki fragments
2278:(10): 1778â1786.
2177:978-0-323-54432-0
2130:978-0-7020-7039-6
2009:(15): 8084â8095.
1623:(4): 688â700.e3.
1379:(5228): 1236â41.
1278:gastric carcinoma
1232:Loss of function
1191:RNA polymerase II
1185:from a dedicated
919:
918:
833:
832:
747:
746:
657:
656:
653:
652:
629:
628:
593:
592:
574:
573:
550:
549:
531:
530:
507:
506:
490:
489:
460:
459:
443:
442:
417:
416:
400:
399:
348:
347:
344:
343:
322:
321:
309:
308:
290:
289:
247:bone marrow cells
188:
187:
4023:
3743:DNA polymerase I
3627:
3587:Replication fork
3479:Licensing factor
3295:
3266:
3259:
3252:
3243:
3182:
3172:
3139:
3121:
3096:
3086:
3053:
3043:
3018:
2989:
2971:
2946:
2936:
2903:
2884:10.1038/35096585
2858:
2829:
2819:
2794:
2757:
2739:
2714:
2669:
2632:
2602:
2592:
2559:
2549:
2524:
2487:
2469:
2434:
2433:
2396:
2390:
2389:
2353:
2347:
2346:
2310:
2304:
2303:
2267:
2261:
2260:
2250:
2210:
2204:
2203:
2197:
2189:
2163:
2157:
2156:
2150:
2142:
2116:
2110:
2109:
2099:
2067:
2061:
2060:
2058:
2057:
2043:
2037:
2036:
2026:
1994:
1985:
1984:
1948:
1942:
1941:
1931:
1899:
1893:
1892:
1874:
1865:(25): 23502â15.
1850:
1844:
1843:
1836:
1830:
1829:
1819:
1787:
1778:
1777:
1767:
1757:
1740:(51): 20325â32.
1725:
1702:
1701:
1691:
1681:
1657:
1651:
1650:
1640:
1608:
1587:
1586:
1558:
1552:
1551:
1541:
1517:
1511:
1510:
1500:
1468:
1462:
1461:
1451:
1419:
1413:
1412:
1368:
1362:
1361:
1350:
1344:
1334:
1309:cancer biomarker
1286:Type II diabetes
1213:hypermethylation
924:, also known as
847:
835:
761:
749:
671:
659:
642:
641:
625:
610:
605:
588:
578:
569:
559:
555:RefSeq (protein)
545:
535:
526:
516:
494:
471:
447:
428:
404:
385:
354:
333:
318:
294:
239:
237:Top expressed in
232:
211:
194:
184:
171:
160:
145:
138:
132:
121:
107:
91:
85:
83:TERC - orthologs
52:
45:
31:
19:
4031:
4030:
4026:
4025:
4024:
4022:
4021:
4020:
3996:
3995:
3994:
3989:
3946:
3924:
3764:
3760:
3754:
3748:Klenow fragment
3631:
3612:
3596:leading strands
3560:
3370:
3366:
3360:
3299:
3284:
3273:DNA replication
3270:
3190:
3185:
3142:
3099:
3069:(20): 4470â80.
3056:
3034:(14): 3442â50.
3021:
2992:
2949:
2906:
2870:(6854): 432â5.
2861:
2832:
2797:
2763:Nature Genetics
2760:
2717:
2681:(6761): 551â5.
2672:
2644:(10): 1345â50.
2635:
2605:
2562:
2527:
2490:
2447:
2443:
2441:Further reading
2438:
2437:
2398:
2397:
2393:
2355:
2354:
2350:
2312:
2311:
2307:
2269:
2268:
2264:
2212:
2211:
2207:
2190:
2178:
2165:
2164:
2160:
2143:
2131:
2118:
2117:
2113:
2069:
2068:
2064:
2055:
2053:
2045:
2044:
2040:
1996:
1995:
1988:
1950:
1949:
1945:
1914:(12): a032383.
1901:
1900:
1896:
1852:
1851:
1847:
1838:
1837:
1833:
1789:
1788:
1781:
1727:
1726:
1705:
1659:
1658:
1654:
1610:
1609:
1590:
1560:
1559:
1555:
1532:(16): 1984â98.
1519:
1518:
1514:
1470:
1469:
1465:
1421:
1420:
1416:
1370:
1369:
1365:
1352:
1351:
1347:
1335:
1326:
1321:
1250:aplastic anemia
1230:
1167:
1153:stimulates the
1032:
980:
860:Sacc_telomerase
684:Telomerase-vert
646:View/Edit Human
623:
608:
601:
598:Location (UCSC)
586:
567:
543:
524:
482:
437:ENSG00000277925
314:
305:
286:
281:
277:
273:
269:
267:Achilles tendon
265:
261:
257:
253:
249:
235:
179:
166:
158:
148:
147:
146:
139:
117:
94:Gene location (
61:
48:
41:
17:
12:
11:
5:
4029:
4027:
4019:
4018:
4013:
4011:Non-coding RNA
4008:
3998:
3997:
3991:
3990:
3988:
3987:
3986:
3985:
3980:
3975:
3960:
3958:
3952:
3951:
3948:
3947:
3945:
3944:
3939:
3932:
3930:
3926:
3925:
3923:
3922:
3916:
3915:
3914:
3913:
3902:
3901:
3900:
3899:
3894:
3889:
3884:
3874:
3873:
3872:
3867:
3862:
3857:
3847:
3846:
3845:
3840:
3835:
3830:
3820:
3813:
3812:
3811:
3810:
3800:
3795:
3794:
3793:
3783:
3782:
3781:
3770:
3768:
3756:
3755:
3753:
3752:
3751:
3750:
3735:
3734:
3733:
3732:
3722:
3717:
3712:
3707:
3706:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3670:
3665:
3660:
3655:
3650:
3639:
3637:
3624:
3618:
3617:
3614:
3613:
3611:
3610:
3605:
3600:
3599:
3598:
3583:
3582:
3568:
3566:
3562:
3561:
3559:
3558:
3553:
3543:
3542:
3532:
3531:
3530:
3529:
3524:
3513:
3512:
3511:
3510:
3505:
3500:
3489:
3488:
3482:
3481:
3475:
3474:
3473:
3472:
3467:
3462:
3457:
3452:
3447:
3436:
3435:
3429:
3428:
3422:
3421:
3420:
3419:
3414:
3409:
3404:
3399:
3394:
3383:
3382:
3376:
3374:
3369:preparation in
3362:
3361:
3359:
3358:
3357:
3356:
3345:
3344:
3343:
3342:
3337:
3332:
3321:
3320:
3314:
3313:
3307:
3305:
3292:
3286:
3285:
3271:
3269:
3268:
3261:
3254:
3246:
3240:
3239:
3230:
3228:
3219:
3217:
3208:
3206:
3201:
3196:
3189:
3188:External links
3186:
3184:
3183:
3140:
3097:
3054:
3019:
2990:
2947:
2904:
2859:
2830:
2804:Molecular Cell
2795:
2758:
2715:
2695:10.1038/990141
2670:
2633:
2603:
2560:
2525:
2488:
2444:
2442:
2439:
2436:
2435:
2391:
2364:(2): 526â534.
2348:
2305:
2262:
2205:
2176:
2158:
2129:
2111:
2062:
2038:
1986:
1959:(5): 299â309.
1943:
1894:
1845:
1831:
1779:
1703:
1652:
1617:Molecular Cell
1588:
1553:
1512:
1463:
1414:
1363:
1345:
1323:
1322:
1320:
1317:
1258:Overexpression
1254:myelodysplasia
1229:
1226:
1166:
1163:
1101:, the protein
1031:
1028:
979:
976:
974:-like domain.
917:
916:
911:
904:
903:
898:
892:
891:
886:
879:
878:
874:
873:
868:
862:
861:
858:
854:
853:
849:
848:
840:
839:
831:
830:
825:
818:
817:
812:
806:
805:
800:
793:
792:
788:
787:
782:
776:
775:
774:Telomerase-cil
772:
768:
767:
763:
762:
754:
753:
745:
744:
739:
732:
731:
722:
716:
715:
710:
703:
702:
698:
697:
692:
686:
685:
682:
678:
677:
673:
672:
664:
663:
655:
654:
651:
650:
648:
638:
637:
631:
630:
627:
626:
621:
619:
612:
611:
606:
599:
595:
594:
591:
590:
582:
581:
575:
572:
571:
563:
562:
556:
552:
551:
548:
547:
539:
538:
532:
529:
528:
520:
519:
513:
509:
508:
505:
504:
498:
497:
491:
488:
487:
475:
474:
468:
462:
461:
458:
457:
451:
450:
444:
441:
440:
432:
431:
425:
419:
418:
415:
414:
408:
407:
401:
398:
397:
389:
388:
382:
376:
375:
370:
365:
361:
360:
350:
349:
346:
345:
342:
341:
338:
337:
330:
324:
323:
320:
319:
311:
310:
307:
306:
304:
301:
298:
297:
291:
288:
287:
285:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
241:
240:
228:
227:
219:
208:
202:
201:
198:RNA expression
190:
189:
186:
185:
177:
173:
172:
164:
161:
156:
150:
149:
140:
133:
127:
123:
122:
115:
109:
108:
100:
99:
87:
86:
59:
55:
54:
46:
38:
37:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4028:
4017:
4014:
4012:
4009:
4007:
4004:
4003:
4001:
3984:
3981:
3979:
3976:
3974:
3971:
3970:
3969:
3965:
3962:
3961:
3959:
3957:
3953:
3943:
3940:
3938:
3934:
3933:
3931:
3927:
3921:
3918:
3917:
3912:
3909:
3908:
3907:
3904:
3903:
3898:
3895:
3893:
3890:
3888:
3885:
3883:
3880:
3879:
3878:
3875:
3871:
3868:
3866:
3863:
3861:
3858:
3856:
3853:
3852:
3851:
3848:
3844:
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3825:
3824:
3821:
3818:
3815:
3814:
3809:
3806:
3805:
3804:
3801:
3799:
3798:Topoisomerase
3796:
3792:
3789:
3788:
3787:
3784:
3780:
3777:
3776:
3775:
3772:
3771:
3769:
3766:
3757:
3749:
3746:
3745:
3744:
3740:
3737:
3736:
3731:
3728:
3727:
3726:
3725:Topoisomerase
3723:
3721:
3718:
3716:
3713:
3711:
3708:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3645:
3644:
3641:
3640:
3638:
3635:
3628:
3625:
3623:
3619:
3609:
3606:
3604:
3601:
3597:
3593:
3590:
3589:
3588:
3585:
3584:
3581:
3577:
3573:
3570:
3569:
3567:
3563:
3557:
3554:
3552:
3548:
3545:
3544:
3541:
3537:
3534:
3533:
3528:
3525:
3523:
3520:
3519:
3518:
3515:
3514:
3509:
3506:
3504:
3501:
3499:
3496:
3495:
3494:
3491:
3490:
3487:
3484:
3483:
3480:
3477:
3476:
3471:
3468:
3466:
3463:
3461:
3458:
3456:
3453:
3451:
3448:
3446:
3443:
3442:
3441:
3438:
3437:
3434:
3431:
3430:
3427:
3424:
3423:
3418:
3415:
3413:
3410:
3408:
3405:
3403:
3400:
3398:
3395:
3393:
3390:
3389:
3388:
3385:
3384:
3381:
3378:
3377:
3375:
3372:
3363:
3355:
3352:
3351:
3350:
3347:
3346:
3341:
3338:
3336:
3333:
3331:
3328:
3327:
3326:
3323:
3322:
3319:
3316:
3315:
3312:
3309:
3308:
3306:
3303:
3296:
3293:
3291:
3287:
3282:
3278:
3274:
3267:
3262:
3260:
3255:
3253:
3248:
3247:
3244:
3238:
3234:
3231:
3229:
3227:
3223:
3220:
3218:
3216:
3212:
3209:
3207:
3205:
3202:
3200:
3197:
3195:
3192:
3191:
3187:
3180:
3176:
3171:
3166:
3162:
3158:
3155:(4): 912â20.
3154:
3150:
3146:
3141:
3137:
3133:
3129:
3125:
3120:
3115:
3111:
3107:
3103:
3098:
3094:
3090:
3085:
3080:
3076:
3072:
3068:
3064:
3060:
3055:
3051:
3047:
3042:
3037:
3033:
3029:
3025:
3020:
3016:
3012:
3008:
3004:
3000:
2996:
2991:
2987:
2983:
2979:
2975:
2970:
2965:
2961:
2957:
2956:Cell Research
2953:
2948:
2944:
2940:
2935:
2930:
2926:
2922:
2919:(2): 559â68.
2918:
2914:
2910:
2905:
2901:
2897:
2893:
2889:
2885:
2881:
2877:
2873:
2869:
2865:
2860:
2856:
2852:
2848:
2844:
2841:(3): 559â65.
2840:
2836:
2831:
2827:
2823:
2818:
2813:
2810:(2): 361â71.
2809:
2805:
2801:
2796:
2792:
2788:
2784:
2780:
2776:
2775:10.1038/79232
2772:
2768:
2764:
2759:
2755:
2751:
2747:
2743:
2738:
2733:
2730:(5): 503â14.
2729:
2725:
2721:
2716:
2712:
2708:
2704:
2700:
2696:
2692:
2688:
2684:
2680:
2676:
2671:
2667:
2663:
2659:
2655:
2651:
2647:
2643:
2639:
2634:
2630:
2626:
2622:
2618:
2614:
2610:
2604:
2600:
2596:
2591:
2586:
2582:
2578:
2574:
2570:
2566:
2561:
2557:
2553:
2548:
2543:
2539:
2535:
2531:
2526:
2522:
2518:
2514:
2510:
2506:
2502:
2498:
2494:
2489:
2485:
2481:
2477:
2473:
2468:
2463:
2459:
2455:
2451:
2446:
2445:
2440:
2431:
2427:
2423:
2419:
2415:
2411:
2407:
2403:
2395:
2392:
2387:
2383:
2379:
2375:
2371:
2367:
2363:
2359:
2352:
2349:
2344:
2340:
2336:
2332:
2328:
2324:
2321:(2): 139â44.
2320:
2316:
2309:
2306:
2301:
2297:
2293:
2289:
2285:
2281:
2277:
2273:
2266:
2263:
2258:
2254:
2249:
2244:
2240:
2236:
2232:
2228:
2224:
2220:
2216:
2209:
2206:
2201:
2195:
2187:
2183:
2179:
2173:
2170:. St. Louis.
2169:
2162:
2159:
2154:
2148:
2140:
2136:
2132:
2126:
2122:
2115:
2112:
2107:
2103:
2098:
2093:
2089:
2085:
2081:
2077:
2073:
2066:
2063:
2052:
2048:
2042:
2039:
2034:
2030:
2025:
2020:
2016:
2012:
2008:
2004:
2000:
1993:
1991:
1987:
1982:
1978:
1974:
1970:
1966:
1962:
1958:
1954:
1947:
1944:
1939:
1935:
1930:
1925:
1921:
1917:
1913:
1909:
1905:
1898:
1895:
1890:
1886:
1882:
1878:
1873:
1868:
1864:
1860:
1856:
1849:
1846:
1841:
1835:
1832:
1827:
1823:
1818:
1813:
1809:
1805:
1801:
1797:
1793:
1786:
1784:
1780:
1775:
1771:
1766:
1761:
1756:
1751:
1747:
1743:
1739:
1735:
1731:
1724:
1722:
1720:
1718:
1716:
1714:
1712:
1710:
1708:
1704:
1699:
1695:
1690:
1685:
1680:
1675:
1671:
1667:
1663:
1656:
1653:
1648:
1644:
1639:
1634:
1630:
1626:
1622:
1618:
1614:
1607:
1605:
1603:
1601:
1599:
1597:
1595:
1593:
1589:
1584:
1580:
1576:
1572:
1569:(3): 307â18.
1568:
1564:
1557:
1554:
1549:
1545:
1540:
1535:
1531:
1527:
1523:
1516:
1513:
1508:
1504:
1499:
1494:
1490:
1486:
1483:(7): 1091â7.
1482:
1478:
1474:
1467:
1464:
1459:
1455:
1450:
1445:
1441:
1437:
1434:(2): 944â54.
1433:
1429:
1425:
1418:
1415:
1410:
1406:
1402:
1398:
1394:
1390:
1386:
1382:
1378:
1374:
1367:
1364:
1359:
1355:
1349:
1346:
1342:
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1333:
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1325:
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1310:
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1302:
1297:
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1287:
1283:
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1267:
1263:
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1255:
1251:
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1243:
1239:
1235:
1227:
1225:
1222:
1218:
1214:
1211:
1206:
1204:
1200:
1196:
1192:
1188:
1187:promoter site
1184:
1180:
1176:
1172:
1164:
1162:
1160:
1156:
1152:
1148:
1144:
1140:
1136:
1132:
1128:
1124:
1120:
1116:
1112:
1108:
1104:
1100:
1096:
1092:
1087:
1085:
1081:
1077:
1073:
1071:
1066:
1062:
1058:
1057:somatic cells
1054:
1049:
1045:
1041:
1037:
1029:
1023:
1019:
1017:
1013:
1009:
1005:
1001:
997:
993:
989:
985:
977:
975:
973:
970:
966:
963:
959:
955:
951:
947:
943:
939:
935:
931:
927:
923:
915:
912:
909:
905:
902:
899:
897:
893:
890:
887:
884:
880:
875:
872:
869:
867:
863:
859:
855:
850:
846:
841:
836:
829:
826:
823:
819:
816:
813:
811:
807:
804:
801:
798:
794:
789:
786:
783:
781:
777:
773:
769:
764:
760:
755:
750:
743:
740:
737:
733:
730:
726:
723:
721:
717:
714:
711:
708:
704:
699:
696:
693:
691:
687:
683:
679:
674:
670:
665:
660:
647:
643:
639:
636:
632:
622:
620:
617:
613:
607:
604:
600:
596:
589:
583:
579:
576:
570:
564:
560:
557:
553:
546:
540:
536:
533:
527:
521:
517:
514:
512:RefSeq (mRNA)
510:
503:
499:
495:
492:
486:
485:
481:
476:
472:
469:
467:
463:
456:
452:
448:
445:
439:
438:
433:
429:
426:
424:
420:
413:
409:
405:
402:
396:
395:
390:
386:
383:
381:
377:
374:
371:
369:
366:
362:
359:
355:
351:
339:
334:
331:
329:
325:
317:
312:
302:
299:
295:
292:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
245:
242:
238:
233:
230:
229:
226:
224:
220:
218:
217:
213:
212:
209:
207:
203:
199:
195:
191:
183:
178:
174:
170:
165:
155:
151:
144:
137:
131:
124:
120:
114:
110:
106:
101:
97:
92:
88:
84:
80:
76:
72:
68:
64:
56:
51:
44:
39:
34:
30:
25:
20:
3977:
3937:Processivity
3763:synthesis in
3152:
3148:
3112:(5): 511â7.
3109:
3105:
3066:
3062:
3031:
3027:
3001:(2): 201â9.
2998:
2994:
2962:(1): 55â62.
2959:
2955:
2916:
2912:
2867:
2863:
2838:
2834:
2807:
2803:
2766:
2762:
2727:
2723:
2678:
2674:
2641:
2637:
2615:(2): 293â4.
2612:
2608:
2575:(3): 532â3.
2572:
2568:
2540:(3): 202â9.
2537:
2533:
2499:(26): 1â23.
2496:
2492:
2460:(3): 273â5.
2457:
2453:
2405:
2401:
2394:
2361:
2357:
2351:
2318:
2314:
2308:
2275:
2271:
2265:
2225:(1): 15926.
2222:
2218:
2208:
2167:
2161:
2120:
2114:
2079:
2076:Cell Reports
2075:
2065:
2054:. Retrieved
2051:www.omim.org
2050:
2041:
2006:
2002:
1956:
1952:
1946:
1911:
1907:
1897:
1862:
1858:
1848:
1834:
1802:(8): 683â9.
1799:
1795:
1737:
1733:
1669:
1665:
1655:
1620:
1616:
1566:
1562:
1556:
1529:
1525:
1515:
1480:
1476:
1466:
1431:
1427:
1417:
1376:
1372:
1366:
1357:
1348:
1305:osteogenesis
1301:osteoporosis
1298:
1282:inflammatory
1231:
1207:
1169:Unlike most
1168:
1165:Biosynthesis
1135:cajal bodies
1088:
1069:
1033:
981:
933:
929:
925:
921:
920:
585:
566:
542:
523:
501:
478:
454:
435:
411:
392:
372:
367:
221:
214:
180:169,765,047
167:169,764,610
58:External IDs
3956:Termination
3630:Prokaryotic
3622:Replication
3298:Prokaryotic
3277:prokaryotic
3275:(comparing
2769:(1): 85â8.
1796:RNA Biology
1274:oncogenesis
1183:transcribed
1179:spliceosome
1061:oncogenesis
954:replication
852:Identifiers
766:Identifiers
676:Identifiers
263:sural nerve
36:Identifiers
4000:Categories
3968:Telomerase
3942:DNA ligase
3935:Movement:
3759:Eukaryotic
3730:DNA gyrase
3715:DNA ligase
3634:elongation
3365:Eukaryotic
3302:initiation
3290:Initiation
3281:eukaryotic
2408:: 104354.
2186:1053744041
2139:1023865227
2056:2020-03-02
1343:, May 2017
1319:References
1272:-mediated
1099:telomerase
1053:senescence
1036:eukaryotes
1016:Cajal body
992:pseudoknot
982:TERC is a
965:pseudoknot
946:telomerase
942:eukaryotes
910:structures
877:Other data
824:structures
791:Other data
738:structures
701:Other data
225:(ortholog)
3906:DNA clamp
3720:DNA clamp
3710:Replisome
2430:209385638
2386:211024218
2194:cite book
2147:cite book
1234:mutations
1159:cytokines
1129:, NOP10,
1121:complex (
1072:synthesis
1006:, NOP10,
978:Structure
950:telomeres
940:found in
901:Eukaryote
896:Domain(s)
815:Eukaryote
810:Domain(s)
725:Eukaryote
720:Domain(s)
358:Orthologs
71:GeneCards
3964:Telomere
3580:Replicon
3536:Helicase
3527:RNASEH2A
3371:G1 phase
3325:Helicase
3179:11842102
3136:45381814
3128:12496479
3093:12384594
3050:12135483
3015:12083802
2986:36839452
2978:11942411
2943:11788719
2892:11574891
2855:11511096
2826:10983983
2783:10973255
2754:15642776
2746:10721988
2703:10591218
2638:Oncogene
2609:Genomics
2556:17625368
2521:38163343
2513:15613268
2484:14642341
2476:10458601
2422:31837325
2378:32016954
2343:21966828
2300:53085869
2292:30846849
2272:Oncogene
2257:31685833
2106:32023455
2033:31294790
1981:61156603
1973:30760854
1938:31451513
1889:24301693
1881:15811851
1826:27245259
1774:21844345
1698:31157162
1647:30930056
1583:16713250
1458:16319170
1339:–
1315:(LUSC).
1221:Dyskerin
1119:Dyskerin
1111:ribozyme
1080:Homologs
1067:, since
1040:telomere
1030:Function
1000:Dyskerin
988:Telomere
936:, is an
635:Wikidata
255:testicle
3877:epsilon
3765:S phase
3592:Lagging
3547:Primase
3522:RNASEH1
3517:RNase H
3349:Primase
2900:4348062
2872:Bibcode
2791:1873111
2711:4430482
2683:Bibcode
2666:2699389
2658:9546436
2629:9143511
2599:8602368
2335:9713339
2248:6828729
2227:Bibcode
2097:7156301
2024:6735767
1929:6886448
1817:4993324
1765:3251123
1742:Bibcode
1689:6533802
1672:: 344.
1638:6525023
1548:7958872
1507:7739888
1449:1356602
1409:9440710
1401:7544491
1381:Bibcode
1373:Science
1341:Ensembl
1262:cancers
1203:exosome
1177:by the
1175:introns
1171:lncRNAs
1070:de novo
1046:) with
871:RF01050
785:RF00025
695:RF00024
466:UniProt
423:Ensembl
364:Species
200:pattern
43:Aliases
3608:Primer
3177:
3170:100349
3167:
3134:
3126:
3091:
3084:137139
3081:
3048:
3013:
2984:
2976:
2941:
2931:
2898:
2890:
2864:Nature
2853:
2824:
2789:
2781:
2752:
2744:
2709:
2701:
2675:Nature
2664:
2656:
2627:
2597:
2590:145649
2587:
2554:
2519:
2511:
2482:
2474:
2428:
2420:
2384:
2376:
2341:
2333:
2298:
2290:
2255:
2245:
2184:
2174:
2137:
2127:
2104:
2094:
2031:
2021:
1979:
1971:
1936:
1926:
1887:
1879:
1824:
1814:
1772:
1762:
1696:
1686:
1645:
1635:
1581:
1546:
1505:
1498:306816
1495:
1456:
1446:
1407:
1399:
1252:, and
1147:tyrobp
1107:lncRNA
972:snoRNA
857:Symbol
771:Symbol
681:Symbol
618:search
616:PubMed
380:Entrez
328:BioGPS
279:kidney
271:tonsil
159:3q26.2
67:602322
3897:POLE4
3892:POLE3
3887:POLE2
3870:POLD4
3865:POLD3
3860:POLD2
3855:POLD1
3850:delta
3843:PRIM2
3838:PRIM1
3833:POLA2
3828:POLA1
3823:alpha
3556:PRIM2
3551:PRIM1
3508:SSBP4
3503:SSBP3
3498:SSBP2
3132:S2CID
2982:S2CID
2934:99832
2896:S2CID
2787:S2CID
2750:S2CID
2707:S2CID
2662:S2CID
2517:S2CID
2480:S2CID
2426:S2CID
2382:S2CID
2339:S2CID
2296:S2CID
1977:S2CID
1885:S2CID
1405:S2CID
1294:NF-ÎșB
1210:TGS-1
1155:NF-ÎșB
1151:Usp16
1139:genes
969:H/ACA
938:ncRNA
729:Virus
373:Mouse
368:Human
283:blood
223:Mouse
216:Human
163:Start
96:Human
3983:DKC1
3978:TERC
3973:TERT
3929:Both
3911:PCNA
3882:POLE
3808:RPA1
3791:FEN1
3779:RFC1
3703:holE
3698:holD
3693:holC
3688:holB
3683:holA
3678:dnaX
3673:dnaT
3668:dnaQ
3663:dnaN
3658:dnaH
3653:dnaE
3648:dnaC
3594:and
3565:Both
3540:HFM1
3470:MCM7
3465:MCM6
3460:MCM5
3455:MCM4
3450:MCM3
3445:MCM2
3433:Cdt1
3426:Cdc6
3417:ORC6
3412:ORC5
3407:ORC4
3402:ORC3
3397:ORC2
3392:ORC1
3354:dnaG
3335:dnaB
3330:dnaA
3318:dnaC
3237:Rfam
3226:Rfam
3215:Rfam
3175:PMID
3124:PMID
3089:PMID
3046:PMID
3011:PMID
2974:PMID
2939:PMID
2888:PMID
2851:PMID
2822:PMID
2779:PMID
2742:PMID
2724:Cell
2699:PMID
2654:PMID
2625:PMID
2595:PMID
2552:PMID
2509:PMID
2472:PMID
2454:Cell
2418:PMID
2374:PMID
2331:PMID
2288:PMID
2253:PMID
2200:link
2182:OCLC
2172:ISBN
2153:link
2135:OCLC
2125:ISBN
2102:PMID
2029:PMID
1969:PMID
1934:PMID
1877:PMID
1822:PMID
1770:PMID
1694:PMID
1643:PMID
1579:PMID
1544:PMID
1503:PMID
1454:PMID
1397:PMID
1288:and
1215:the
1199:PARN
1131:NHP2
1127:GAR1
1123:DKC1
1115:TERT
1103:TERT
1095:TERT
1044:TERT
1008:NHP2
1004:GAR1
996:TERT
934:TERC
914:PDBe
889:Gene
885:type
866:Rfam
828:PDBe
803:Gene
799:type
780:Rfam
742:PDBe
713:Gene
709:type
690:Rfam
394:7012
275:lung
206:Bgee
154:Band
113:Chr.
75:TERC
63:OMIM
50:TERC
22:TERC
3576:Ori
3279:to
3235:at
3224:at
3213:at
3165:PMC
3157:doi
3114:doi
3079:PMC
3071:doi
3036:doi
3032:269
3003:doi
2999:277
2964:doi
2929:PMC
2921:doi
2880:doi
2868:413
2843:doi
2839:286
2812:doi
2771:doi
2732:doi
2728:100
2691:doi
2679:402
2646:doi
2617:doi
2585:PMC
2577:doi
2542:doi
2501:doi
2462:doi
2410:doi
2406:112
2366:doi
2323:doi
2319:185
2280:doi
2243:PMC
2235:doi
2092:PMC
2084:doi
2019:PMC
2011:doi
1961:doi
1924:PMC
1916:doi
1867:doi
1863:280
1812:PMC
1804:doi
1760:PMC
1750:doi
1738:108
1684:PMC
1674:doi
1633:PMC
1625:doi
1571:doi
1534:doi
1493:PMC
1485:doi
1444:PMC
1436:doi
1389:doi
1377:269
1270:MDV
1266:HPV
1205:.
1091:RNA
1012:RNP
932:or
930:TER
908:PDB
883:RNA
822:PDB
797:RNA
736:PDB
707:RNA
624:n/a
609:n/a
587:n/a
568:n/a
544:n/a
525:n/a
502:n/a
455:n/a
412:n/a
336:n/a
303:n/a
176:End
79:OMA
4002::
3966::
3741::
3549::
3538::
3340:T7
3173:.
3163:.
3153:30
3151:.
3147:.
3130:.
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