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OH (methanol). Even at low concentrations inhalation causes lung lesions, and at slightly higher concentrations eye contact with the vapor causes blindness. Worse, at low concentrations (200 ppm/15 min) the damage is often insidious, with onset of symptoms hours after exposure. The mode of action
692:
are well established, methanol causes blindness via conversion to formaldehyde, then to toxic formic acid in the liver; methanol splashes to the eye cause only moderate and reversible eye irritation.
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sheets, the methanol produced is only a risk through chronic exposure and is a comparatively small concern. The mechanisms of
402:
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is the precipitation of silica in the eyes and/or lungs. Contrary to common information, including several erroneous
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Sakurai, H. "Silicon(IV) Methoxide" in
Encyclopedia of Reagents for Organic Synthesis 2001 John Wiley & Sons.
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442:
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67:
tetramethyl orthosilicate; methyl silicate; silicic acid, tetramethyl ester; silicon methoxide; TMOS
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Except where otherwise noted, data are given for materials in their
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783:
Hazardous
Substances Data Bank - National Library of Medicine
757:
National
Library of Medicine - Hazardous Substances Data Bank
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atom. The basic properties are similar to the more popular
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35:
26:
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121 to 122 °C (250 to 252 °F; 394 to 395 K)
523:
723:
National
Institute for Occupational Safety and Health
359:
4 to 5 °C (39 to 41 °F; 277 to 278 K)
578:, which is usually preferred because the product of
176:
88:
8:
823:CDC - NIOSH Pocket Guide to Chemical Hazards
254:InChI=1S/C4H12O4Si/c1-5-9(6-2,7-3)8-4/h1-4H3
593:Tetramethyl orthosilicate hydrolyzes to SiO
264:InChI=1/C4H12O4Si/c1-5-9(6-2,7-3)8-4/h1-4H3
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154:
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717:NIOSH Pocket Guide to Chemical Hazards.
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257:Key: LFQCEHFDDXELDD-UHFFFAOYSA-N
7:
426:96 °C; 205 °F; 369 K
267:Key: LFQCEHFDDXELDD-UHFFFAOYAT
167:
566:. This molecule consists of four
14:
548:Tetramethyl orthosilicate (TMOS)
513:
509:(at 25 °C , 100 kPa).
785:. National Library of Medicine
759:. National Library of Medicine
403:Occupational safety and health
1:
436:(US health exposure limits):
22:
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17:Tetramethyl orthosilicate
643:has been used to convert
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59:Tetramethyl orthosilicate
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741:10.1002/047084289X.rs012
667:The hydrolysis of Si(OCH
576:tetraethyl orthosilicate
753:"Tetramethyl silicate"
675:produces insoluble SiO
40:
31:
651:to the corresponding
586:, is less toxic than
39:
30:
807:WebBook page for SiC
331:152.25
498:Trimethyl phosphite
462:TWA 1 ppm (6 mg/m)
376:Solubility in water
18:
536:Infobox references
480:Related compounds
471:(Immediate danger)
339:colourless liquid
41:
32:
16:
690:methanol toxicity
633:organic synthesis
552:chemical compound
544:Chemical compound
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541:
381:organic solvents
210:CompTox Dashboard
114:Interactive image
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494:Trimethyl borate
304:Chemical formula
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843:Silicate esters
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391:12 mmHg (25°C)
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838:Methyl esters
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787:. Retrieved
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761:. Retrieved
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666:
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570:bonded to a
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412:Main hazards
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288:CO(OC)(OC)OC
73:Identifiers
65:Other names
789:11 February
763:11 February
422:Flash point
406:(OHS/OSH):
336:Appearance
297:Properties
152:100.010.598
832:Categories
779:"Methanol"
696:References
580:hydrolysis
327:Molar mass
198:19D35VPL66
125:ChemSpider
101:3D model (
80:CAS Number
56:IUPAC name
649:aldehydes
554:with the
725:(NIOSH).
635:, Si(OCH
588:methanol
396:Hazards
90:681-84-5
719:"#0428"
657:acetals
645:ketones
584:ethanol
572:silicon
556:formula
550:is the
529:what is
527: (
488:cations
345:Density
321:
165:PubChem
679:and CH
663:Safety
653:ketals
613:O →
609:+ 2 H
601:Si(OCH
558:Si(OCH
524:verify
521:
486:Other
416:toxic
349:1.032
281:SMILES
50:Names
620:+ 4
475:N.D.
449:none
433:NIOSH
246:InChI
178:12682
134:12161
103:JSmol
791:2013
765:2013
686:MSDS
655:and
647:and
469:IDLH
189:UNII
737:doi
631:In
615:SiO
456:REL
443:PEL
309:SiC
215:EPA
168:CID
834::
813:12
781:.
755:.
721:.
703:^
626:OH
622:CH
597::
590:.
582:,
315:12
817:4
815:O
811:H
809:4
793:.
767:.
739::
681:3
677:2
673:4
671:)
669:3
641:4
639:)
637:3
624:3
617:2
611:2
607:4
605:)
603:3
595:2
564:4
562:)
560:3
519:Y
319:4
317:O
313:H
311:4
217:)
213:(
105:)
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