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Theophylline/ephedrine

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228:. It was first studied and used to treat asthma in the 1930s or 1940s and combinations of the two drugs subsequently became widely used. A ratio of 5:1 theophylline to ephedrine is usually used in combinations of the drugs. Later research found that the combination was no more effective for asthma than theophylline alone but produced more 684:
became popular as an oral agent, particularly in fixed-dose combination with ephedrine. Its predominant use continued in this manner into the early 1970s. Since then, definition of the pharmacodynamics and pharmacokinetics of theophylline has led to its present use as a major prophylactic agent for the prevention of chronic asthma.
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among others as well. Combinations of theophylline, ephedrine, and a barbiturate were later phased out in favor of combinations of theophylline and ephedrine alone (e.g., brand name Franol). Fixed-dose combinations of theophylline and ephedrine were abandoned after the 1970s as they did not allow for
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Theophylline is generally more potent than caffeine in its effects; it was often combined with ephedrine in nasal decongestant products before more selective adrenergic blockers became available. An early study found the theophylline-ephedrine combination no more effective than theophylline alone in
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Brown1 reported uncontrolled clinical observations suggesting the apparent effectiveness of a fixed dose combination of ephedrine and theophylline in 1940, Such preparations have become very popular, though a search of the literature since that initial report unearthed only one controlled study (of
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Dr Lathem, Sterling's Vice President for Scientific Affairs replied to MaLAM that "Franol is approved for marketing in the United Kingdom in a formulation containing theophylline and ephedrine. We have initiated a re-formulation worldwide to make all Franol formulations consistent with those of the
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Team physicians became interested in asthma in elite athletes after the 1972 Olympic Games in Munich. The winner of the men's 400 m freestyle swimming race was disqualified because a significant amount of a banned drug, ephedrine, was found in his postrace urinalysis sample. The swimmer had used a
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The concept of using a single therapy and maximising the dose of ICS might have been driven by the desire to avoid fixed combinations. These were commonly used in the US during the 1970s with products such as Tedral®1 and Marax® that combined theophylline and ephedrine with a sedative. The earlier
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Theophylline has undergone a major transition in clinical use over the past 10 to 15 years. Used primarily for its cardiovascular effects in the early part of this century, theophylline was found in the 1920s to have clinically beneficial effects on acute bronchospasm.1 In the 1930s, theophylline
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Until recently, combination products containing theophylline, ephedrine, and a "sedative" were the most frequently prescribed bronchodilators in the United States. Several studies, however, have documented that the combination of ephedrine and theophylline produce synergistic toxicity without
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combination preparation of theophylline and ephedrine for the treatment of his asthma. Since then both US and Australian Olympic Committees have put special emphasis on the accurate diagnosis and treatment of asthma in their Olympic teams.1,2
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U.K.". Weinberger and Bronsky (1974) compared theophylline and ephedrine separately and combined. They concluded that "the inclusion of ephedrine resulted in no further benefit but did appear to increase the frequency of adverse effects" .
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among others) have also been widely used to treat asthma. Many such combinations have been marketed with numerous brand names. Theophylline has also been marketed in combination with other ephedrine-like sympathomimetics like
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23 asthmatic children, whereas the ADR rate was higher for the combination than for theophylline.40 Another study of asthmatic children, however, showed no additional adverse effects from the combination.
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fixed combinations did not allow for significant dose titration, due to the toxicity of ephedrine, and thus the concept of fixed dosing combinations for asthma was relegated to an 'unacceptable' status.
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Amesec contained ephedrine and amylobarbitone with a whiff of aminophylline. Franol contained ephedrine and theophylline, and earlier versions also contained phenobarbital.
858:. Emergency Medical Care: A Manual for the Paramedic in the Field. U.S. Department of Transportation, National Highway Traffic Safety Administration. 1983. p. 3-PA33 835:. Department of Justice, Drug Enforcement Administration, Office of Compliance and Regulatory Affairs, Regulatory Support Division, Information Systems Section. 1979 1710: 1074: 903:
Mosby's Pocket Dictionary of Medicine, Nursing & Health Professions - E-Book: Mosby's Pocket Dictionary of Medicine, Nursing & Health Professions - E-Book
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have been studied. Use of theophylline/ephedrine combinations has led to disqualification of elite athletes due to ephedrine being banned in competitive sports.
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Pinnas JL, Schachtel BP, Chen TM, Roseberry HR, Thoden WR (March 1991). "Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma".
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Kennedy M (January 2021). "Effects of theophylline and theobromine on exercise performance and implications for competition sport: A systematic review".
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Emergency Department Trends from the Drug Abuse Warning Network: Preliminary Estimates January-June 2001 with Revised Estimates 1994-2000
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Weinberger M, Hendeles L (October 1986). "Therapeutic effect and dosing strategies for theophylline in the treatment of chronic asthma".
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Weinberger M, Bronsky E, Bensch GW, Bock GN, Yecies JJ (May 1975). "Interaction of ephedrine and theophylline".
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Akazawa M, Stempel DA (2006). "Single-inhaler combination therapy for asthma: a review of cost effectiveness".
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Sims JA, doPico GA, Reed CE (July 1978). "Bronchodilating effect of oral theophylline-ephedrine combination".
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Mansfield PR (1991). "Classifying improvements to drug marketing and justifications for claims of efficacy".
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Hendeles L, Weinberger M (1980). "Avoidance of adverse effects during chronic therapy with theophylline".
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Helenius I, Haahtela T (September 2000). "Allergy and asthma in elite summer sport athletes".
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Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies
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The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies
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Theophylline/ephedrine; Theophylline-(–)-ephedrine compound; Theophylline-ephedrine
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significantly enhancing the therapeutic efficacy of theophylline alone (Figure 1).
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very limited scope) that suggested additive effect from drug combination.15
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dose titration in asthma therapy owing to the toxicity of ephedrine.
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O'Loughlin JM (March 1979). "Drug therapy of bronchial asthma".
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Emergency Medical Care: A Manual for the Paramedic in the Field
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Combination of theophylline and ephedrine used to treat asthma
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The International Journal of Risk & Safety in Medicine
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European Journal of Respiratory Diseases. Supplement
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Fluticasone furoate/umeclidinium bromide/vilanterol
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Project Label: Alphabetical Listing by Drug Product
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Elsevier Health Sciences. 2016. p. 810. 329: 327: 325: 323: 94: 4784: 1033:The Journal of Allergy and Clinical Immunology 659:The Journal of Allergy and Clinical Immunology 503:The Journal of Allergy and Clinical Immunology 5752:Tooltip Plasma membrane monoamine transporter 5674:Tooltip Equilibrative nucleoside transporters 5611:Tooltip Concentrative nucleoside transporters 4206: 1854: 1751:Indacaterol/glycopyrronium bromide/mometasone 1082: 235:Combinations of theophylline, ephedrine, and 8: 1721:Budesonide/glycopyrronium bromide/formoterol 21: 276:The effects of theophylline/ephedrine as a 5786: 5601: 4774: 4245: 4213: 4199: 4191: 3128: 2560: 1888: 1861: 1847: 1839: 1557: 1128: 1089: 1075: 1067: 373: 371: 369: 139: 620:Stargrove M, Treasure J, McKee D (2007). 182:Tooltip International Nonproprietary Name 159: 5791: 763:. Elsevier Health Sciences. p. 53. 626:. Elsevier Health Sciences. p. 45. 378:Head S (2022). "A breath of fresh air". 319: 268:has been marketed under the brand name 1590:Arachidonate 5-lipoxygenase inhibitors 797:. ISSN. Elsevier Science. p. 92. 543:Clinical Pharmacology and Therapeutics 20: 794:Annual Reports in Medicinal Chemistry 7: 1786:Theophylline/ephedrine/phenobarbital 698:The Medical Clinics of North America 110: 5173:Tetramethylpyrazine (ligustrazine) 1781:Theophylline/ephedrine/hydroxyzine 1746:Indacaterol/glycopyrronium bromide 594:10.1002/j.1552-4604.1991.tb04969.x 14: 1771:Salbutamol (albuterol)/budesonide 1741:Glycopyrronium bromide/formoterol 1736:Fluticasone propionate/salmeterol 757:Khouzam H, Tan D, Gill T (2007). 476:National Archives (U.S.) (1978). 1608:Thromboxane receptor antagonists 948:10.2165/00019053-200624100-00005 760:Handbook of Emergency Psychiatry 582:Journal of Clinical Pharmacology 6177:Norepinephrine releasing agents 4169:Monoamine metabolism modulators 1791:Umeclidinium bromide/vilanterol 455:World Health Organization (WHO) 6142:Adenosine receptor antagonists 4789:Tooltip Adenosine triphosphate 1761:Ipratropium bromide/salbutamol 1731:Fluticasone furoate/vilanterol 1346:Orciprenaline (metaproterenol) 210:norepinephrine releasing agent 192:among others, is a fixed-dose 52:Norepinephrine releasing agent 1: 6117:Receptor/signaling modulators 4479:8-Phenyl-1,3-dipropylxanthine 4151:Monoamine reuptake inhibitors 4124:Receptor/signaling modulators 1701:Aclidinium bromide/formoterol 1189:Levosalbutamol (levalbuterol) 1008:Sidney KH, Lefcoe NM (1978). 422:. Springer US. p. 1179. 202:adenosine receptor antagonist 40:Adenosine receptor antagonist 1336:Isoprenaline (isoproterenol) 671:10.1016/0091-6749(86)90058-8 515:10.1016/0091-6749(78)90066-0 188:, sold under the brand name 3234:Deoxyepinephrine (epinine, 2611:Deoxyepinephrine (epinine, 2458:Tetracyclic antidepressants 1924:Deoxyepinephrine (epinine, 1311:+theophylline/phenobarbital 1099:obstructive airway diseases 216:, which has been used as a 6203: 5619:6-Hydroxy-7-methoxyflavone 4326:-ethylcarboxamidoadenosine 4160:Monoamine releasing agents 278:performance-enhancing drug 6110: 4114: 2476:Tricyclic antidepressants 1799: 975:Drug Testing and Analysis 6147:Beta-Hydroxyamphetamines 5796:Tooltip Xanthine oxidase 1706:Beclometasone/formoterol 1315:theophylline/hydroxyzine 1255:Ultra-long-acting β 5386:UDP-N-acetylglucosamine 2889:Atypical antipsychotics 2142:Atypical antipsychotics 1562:Leukotriene antagonists 1045:10.1067/mai.2000.107749 194:combination formulation 5830:Cinnamomum osmophloeum 4539:Choline theophyllinate 3088:Typical antipsychotics 2571:(R)-3-Nitrobiphenyline 2507:Typical antipsychotics 1776:Theophylline/ephedrine 1756:Indacaterol/mometasone 1517:Choline theophyllinate 1436:Glycopyrronium bromide 1398:Fluticasone propionate 1185:Salbutamol (albuterol) 791:Heinzelman RV (1972). 451:"INN Proposed List 14" 212:and indirectly acting 186:theophylline/ephedrine 173:Theophylline ephedrine 23:Theophylline/ephedrine 5073:Opiranserin (VVZ-149) 4414:-Cyclopentyladenosine 4178:Monoamine neurotoxins 1766:Mometasone/formoterol 1716:Budesonide/formoterol 1466:Mast cell stabilizers 1423:muscarinic antagonist 555:10.1002/cpt1975175585 348:10.3233/JRS-1991-2401 214:sympathomimetic agent 5872:Pistacia integerrima 5178:Ligusticum wallichii 5156:Ligusticum wallichii 4484:8-Phenyltheophylline 4474:8-Chlorotheophylline 4424:Neladenoson dalanate 3747:Dichloroisoprenaline 1694:Combination products 1456:Umeclidinium bromide 1014:Can J Appl Sport Sci 220:in the treatment of 3426:Phenylpropanolamine 3292:Ethylnorepinephrine 2768:Phenylpropanolamine 2674:Ethylnorepinephrine 2071:Phenylpropanolamine 1977:Ethylnorepinephrine 1870:Adrenergic receptor 1441:Ipratropium bromide 1133:Short-acting β 665:(4 Pt 2): 762–768. 25: 6157:Cardiac stimulants 1826:Never to phase III 1451:Tiotropium bromide 1446:Oxitropium bromide 1431:Aclidinium bromide 1209:Long-acting β 226:nasal decongestant 6162:Combination drugs 6124: 6123: 5947: 5946: 5924:Mycophenolic acid 5783: 5768: 5767: 5598: 5583: 5582: 5579: 5578: 5150:Angelica sinensis 4242: 4188: 4187: 4181: 4172: 4163: 4154: 4145: 4136: 4127: 4110: 4109: 3857:Iodocyanopindolol 3832:Hydroxytertatolol 3752:Dihydroalprenolol 3365: 3357: 3349: 3266: 3118: 3117: 2712: 2704: 2696: 2648: 2630:Dihydroergotamine 2547: 2546: 2380:hydroxynefazodone 2245:dihydroergotamine 2015: 2007: 1999: 1956: 1836: 1835: 1653: 1652: 1359: 1358: 936:PharmacoEconomics 913:978-0-323-41427-2 804:978-0-08-058351-8 770:978-0-323-07661-6 633:978-0-323-02964-3 457:. 31 October 1964 429:978-1-4757-2085-3 170: 169: 6194: 6182:Sympathomimetics 5797: 5793: 5787: 5777: 5753: 5749: 5675: 5671: 5612: 5608: 5602: 5592: 4986:Rheum officinale 4790: 4786: 4775: 4519:Caffeine citrate 4469:7-Methylxanthine 4302:-methyladenosine 4246: 4236: 4215: 4208: 4201: 4192: 4175: 4166: 4157: 4148: 4139: 4130: 4118: 3827:Hydroxycarteolol 3391:Methoxyphenamine 3363: 3355: 3350:-DOPA (levodopa) 3347: 3264: 3238:-methyldopamine) 3129: 3033:Phenoxybenzamine 2710: 2702: 2697:-DOPA (levodopa) 2694: 2646: 2615:-methyldopamine) 2561: 2373:Phenylpiperazine 2363:Phenoxybenzamine 2013: 2005: 2000:-DOPA (levodopa) 1997: 1954: 1938:Dexisometheptene 1928:-methyldopamine) 1889: 1863: 1856: 1849: 1840: 1558: 1418:Anticholinergics 1129: 1091: 1084: 1077: 1068: 1061: 1060: 1028: 1022: 1021: 1005: 999: 998: 987:10.1002/dta.2970 970: 964: 963: 931: 925: 924: 922: 920: 898: 892: 891: 889: 887: 874: 868: 867: 865: 863: 850: 844: 843: 841: 840: 827: 816: 815: 813: 811: 788: 782: 781: 779: 777: 754: 748: 747: 723: 714: 713: 693: 687: 686: 654: 648: 647: 641: 640: 617: 606: 605: 577: 571: 570: 538: 527: 526: 498: 492: 491: 489: 487: 479:Federal Register 473: 467: 466: 464: 462: 447: 441: 440: 438: 436: 413: 407: 406: 392:10.1002/psb.1973 375: 364: 363: 331: 183: 179: 163: 143: 123: 113: 112: 98: 26: 24: 6202: 6201: 6197: 6196: 6195: 6193: 6192: 6191: 6152:Bronchodilators 6137:Abandoned drugs 6127: 6126: 6125: 6120: 6106: 5943: 5897: 5795: 5776: 5764: 5751: 5741: 5737:Propentofylline 5687:Benzodiazepines 5673: 5663: 5610: 5591: 5575: 5194: 5145:Sodium ferulate 5113:Radix puerariae 5088:Phenolphthalein 4788: 4781: 4766: 4758: 4659:Propentofylline 4599:Isovaleric acid 4283: 4275: 4235: 4227: 4222:Purine receptor 4219: 4189: 4184: 4106: 3525: 3114: 2852: 2625:Dexmedetomidine 2556: 2543: 2376:antidepressants 2100: 1933:Desglymidodrine 1884: 1875: 1867: 1837: 1832: 1831: 1816:Clinical trials 1795: 1689: 1649: 1632:PDE4 inhibitors 1625: 1602: 1584: 1546: 1483: 1460: 1421: 1412: 1365:Glucocorticoids 1355: 1341:Methylephedrine 1291: 1258: 1249: 1212: 1203: 1136: 1114: 1095: 1065: 1064: 1030: 1029: 1025: 1007: 1006: 1002: 972: 971: 967: 942:(10): 971–988. 933: 932: 928: 918: 916: 914: 900: 899: 895: 885: 883: 876: 875: 871: 861: 859: 852: 851: 847: 838: 836: 829: 828: 819: 809: 807: 805: 790: 789: 785: 775: 773: 771: 756: 755: 751: 725: 724: 717: 695: 694: 690: 656: 655: 651: 638: 636: 634: 619: 618: 609: 579: 578: 574: 540: 539: 530: 500: 499: 495: 485: 483: 475: 474: 470: 460: 458: 449: 448: 444: 434: 432: 430: 416:Elks J (2014). 415: 414: 410: 377: 376: 367: 333: 332: 321: 316: 294: 252:and with other 250:pseudoephedrine 181: 166: 146: 126: 109: 101: 17: 12: 11: 5: 6200: 6198: 6190: 6189: 6184: 6179: 6174: 6172:Ergogenic aids 6169: 6167:Drugs in sport 6164: 6159: 6154: 6149: 6144: 6139: 6129: 6128: 6122: 6121: 6111: 6108: 6107: 6105: 6104: 6090: 6089: 6084: 6079: 6074: 6069: 6064: 6059: 6054: 6049: 6044: 6039: 6034: 6029: 6024: 6019: 6014: 6009: 6004: 5999: 5994: 5989: 5984: 5979: 5974: 5969: 5964: 5955: 5953: 5949: 5948: 5945: 5944: 5942: 5941: 5936: 5931: 5926: 5921: 5916: 5911: 5905: 5903: 5899: 5898: 5896: 5895: 5890: 5885: 5880: 5875: 5868: 5863: 5858: 5853: 5848: 5843: 5838: 5833: 5826: 5824:Cinnamaldehyde 5821: 5816: 5811: 5806: 5800: 5798: 5784: 5770: 5769: 5766: 5765: 5763: 5762: 5756: 5754: 5743: 5742: 5740: 5739: 5734: 5729: 5727:Pentoxifylline 5724: 5719: 5714: 5709: 5704: 5699: 5694: 5689: 5684: 5678: 5676: 5665: 5664: 5662: 5661: 5656: 5651: 5646: 5641: 5636: 5631: 5626: 5621: 5615: 5613: 5599: 5585: 5584: 5581: 5580: 5577: 5576: 5574: 5573: 5568: 5563: 5558: 5553: 5548: 5543: 5538: 5533: 5528: 5523: 5518: 5513: 5508: 5503: 5498: 5493: 5488: 5483: 5478: 5473: 5468: 5463: 5458: 5453: 5448: 5443: 5438: 5433: 5428: 5423: 5418: 5413: 5404: 5403: 5398: 5393: 5388: 5383: 5378: 5373: 5368: 5363: 5358: 5353: 5348: 5343: 5338: 5333: 5328: 5323: 5318: 5313: 5308: 5303: 5298: 5293: 5288: 5283: 5278: 5273: 5268: 5263: 5258: 5253: 5248: 5243: 5238: 5233: 5228: 5223: 5218: 5213: 5204: 5202: 5196: 5195: 5193: 5192: 5187: 5182: 5170: 5165: 5160: 5142: 5137: 5132: 5127: 5122: 5117: 5105: 5100: 5095: 5090: 5085: 5080: 5075: 5070: 5065: 5060: 5055: 5050: 5045: 5040: 5035: 5030: 5025: 5020: 5015: 5010: 5005: 5000: 4995: 4990: 4978: 4973: 4968: 4963: 4958: 4953: 4948: 4943: 4938: 4933: 4928: 4923: 4918: 4913: 4904: 4903: 4898: 4893: 4888: 4883: 4878: 4873: 4868: 4863: 4858: 4853: 4848: 4843: 4838: 4833: 4828: 4823: 4818: 4813: 4808: 4803: 4794: 4792: 4772: 4760: 4759: 4757: 4756: 4751: 4746: 4741: 4736: 4731: 4726: 4721: 4716: 4711: 4706: 4701: 4696: 4691: 4686: 4681: 4676: 4671: 4666: 4661: 4656: 4651: 4649:Pentoxifylline 4646: 4641: 4636: 4631: 4626: 4621: 4616: 4611: 4606: 4604:Istradefylline 4601: 4596: 4591: 4586: 4581: 4576: 4571: 4566: 4561: 4556: 4551: 4546: 4541: 4536: 4531: 4526: 4521: 4516: 4511: 4506: 4501: 4496: 4491: 4486: 4481: 4476: 4471: 4462: 4461: 4456: 4451: 4446: 4441: 4436: 4431: 4426: 4421: 4416: 4408: 4403: 4398: 4393: 4388: 4383: 4378: 4373: 4368: 4363: 4358: 4353: 4348: 4343: 4338: 4333: 4328: 4319: 4314: 4309: 4304: 4298:2-(1-Hexynyl)- 4291: 4289: 4277: 4276: 4274: 4273: 4268: 4266:8-Aminoadenine 4259: 4257: 4243: 4229: 4228: 4220: 4218: 4217: 4210: 4203: 4195: 4186: 4185: 4183: 4182: 4173: 4164: 4155: 4146: 4137: 4128: 4115: 4112: 4111: 4108: 4107: 4105: 4104: 4099: 4094: 4089: 4084: 4079: 4074: 4069: 4064: 4059: 4054: 4049: 4044: 4039: 4034: 4029: 4024: 4019: 4014: 4009: 4004: 3999: 3994: 3989: 3984: 3979: 3974: 3969: 3964: 3959: 3954: 3949: 3944: 3939: 3934: 3929: 3924: 3919: 3914: 3909: 3904: 3899: 3894: 3889: 3884: 3879: 3874: 3869: 3864: 3859: 3854: 3849: 3844: 3839: 3834: 3829: 3824: 3819: 3814: 3809: 3804: 3799: 3794: 3789: 3784: 3779: 3774: 3769: 3764: 3759: 3754: 3749: 3744: 3739: 3737:Dexpropranolol 3734: 3729: 3724: 3719: 3714: 3709: 3704: 3699: 3694: 3689: 3684: 3679: 3674: 3669: 3664: 3659: 3654: 3649: 3644: 3639: 3634: 3629: 3624: 3619: 3614: 3609: 3604: 3599: 3594: 3589: 3584: 3579: 3574: 3569: 3564: 3559: 3554: 3549: 3544: 3539: 3533: 3531: 3527: 3526: 3524: 3523: 3518: 3513: 3508: 3503: 3498: 3493: 3488: 3483: 3478: 3473: 3468: 3463: 3458: 3453: 3448: 3443: 3438: 3433: 3428: 3423: 3418: 3413: 3408: 3406:Norepinephrine 3403: 3398: 3393: 3388: 3383: 3378: 3373: 3371:Levosalbutamol 3368: 3360: 3358:-Phenylalanine 3352: 3344: 3339: 3334: 3329: 3324: 3319: 3314: 3309: 3304: 3299: 3294: 3289: 3284: 3279: 3274: 3269: 3260: 3255: 3250: 3245: 3240: 3231: 3226: 3221: 3216: 3211: 3206: 3201: 3196: 3191: 3186: 3181: 3176: 3171: 3166: 3161: 3156: 3151: 3146: 3141: 3135: 3133: 3126: 3120: 3119: 3116: 3115: 3113: 3112: 3107: 3092:chlorpromazine 3085: 3080: 3075: 3070: 3065: 3060: 3055: 3050: 3045: 3040: 3035: 3030: 3025: 3020: 3015: 3010: 3005: 3000: 2995: 2990: 2985: 2980: 2975: 2970: 2965: 2960: 2955: 2950: 2928: 2886: 2881: 2876: 2871: 2866: 2860: 2858: 2854: 2853: 2851: 2850: 2848:Xylometazoline 2845: 2840: 2835: 2830: 2825: 2820: 2815: 2810: 2805: 2800: 2795: 2790: 2785: 2780: 2775: 2770: 2765: 2760: 2758:Norepinephrine 2755: 2750: 2745: 2740: 2735: 2730: 2725: 2720: 2715: 2707: 2705:-Phenylalanine 2699: 2691: 2686: 2681: 2676: 2671: 2666: 2661: 2656: 2651: 2642: 2637: 2632: 2627: 2622: 2617: 2608: 2603: 2598: 2593: 2588: 2583: 2578: 2573: 2567: 2565: 2558: 2554: 2549: 2548: 2545: 2544: 2542: 2541: 2536: 2531: 2526: 2511:chlorpromazine 2504: 2499: 2473: 2455: 2450: 2445: 2440: 2435: 2430: 2425: 2420: 2415: 2410: 2405: 2400: 2395: 2370: 2365: 2360: 2355: 2350: 2345: 2340: 2335: 2330: 2325: 2320: 2315: 2310: 2305: 2300: 2295: 2290: 2285: 2280: 2275: 2270: 2265: 2260: 2230: 2225: 2220: 2215: 2210: 2205: 2200: 2170: 2165: 2139: 2134: 2129: 2124: 2119: 2114: 2108: 2106: 2102: 2101: 2099: 2098: 2096:Xylometazoline 2093: 2088: 2083: 2078: 2073: 2068: 2063: 2058: 2053: 2051:Norepinephrine 2048: 2043: 2038: 2033: 2028: 2023: 2018: 2010: 2008:-Phenylalanine 2002: 1994: 1989: 1984: 1979: 1974: 1969: 1964: 1959: 1950: 1945: 1940: 1935: 1930: 1921: 1916: 1911: 1906: 1901: 1895: 1893: 1886: 1882: 1877: 1876: 1868: 1866: 1865: 1858: 1851: 1843: 1834: 1833: 1830: 1829: 1828: 1827: 1824: 1813: 1807: 1801: 1800: 1797: 1796: 1794: 1793: 1788: 1783: 1778: 1773: 1768: 1763: 1758: 1753: 1748: 1743: 1738: 1733: 1728: 1723: 1718: 1713: 1708: 1703: 1697: 1695: 1691: 1690: 1688: 1687: 1682: 1677: 1672: 1667: 1661: 1659: 1658:Others/unknown 1655: 1654: 1651: 1650: 1648: 1647: 1642: 1636: 1634: 1627: 1626: 1624: 1623: 1618: 1612: 1610: 1604: 1603: 1601: 1600: 1594: 1592: 1586: 1585: 1583: 1582: 1577: 1572: 1566: 1564: 1555: 1548: 1547: 1545: 1544: 1539: 1534: 1529: 1524: 1519: 1514: 1509: 1504: 1499: 1493: 1491: 1485: 1484: 1482: 1481: 1476: 1470: 1468: 1462: 1461: 1459: 1458: 1453: 1448: 1443: 1438: 1433: 1427: 1425: 1414: 1413: 1411: 1410: 1405: 1400: 1395: 1390: 1385: 1380: 1375: 1369: 1367: 1361: 1360: 1357: 1356: 1354: 1353: 1348: 1343: 1338: 1333: 1328: 1323: 1318: 1299: 1297: 1293: 1292: 1290: 1289: 1284: 1279: 1274: 1269: 1263: 1261: 1256: 1251: 1250: 1248: 1247: 1242: 1237: 1228: 1223: 1217: 1215: 1210: 1205: 1204: 1202: 1201: 1196: 1191: 1182: 1177: 1172: 1167: 1162: 1157: 1152: 1147: 1141: 1139: 1134: 1126: 1116: 1115: 1096: 1094: 1093: 1086: 1079: 1071: 1063: 1062: 1039:(3): 444–452. 1023: 1000: 965: 926: 912: 893: 869: 845: 817: 803: 783: 769: 749: 715: 704:(2): 391–396. 688: 649: 632: 607: 588:(3): 243–247. 572: 549:(5): 585–592. 528: 493: 468: 442: 428: 408: 365: 342:(4): 171–184. 318: 317: 315: 312: 311: 310: 305: 300: 293: 290: 218:bronchodilator 168: 167: 165: 164: 156: 154: 148: 147: 145: 144: 136: 134: 128: 127: 125: 124: 116: 114: 103: 102: 100: 99: 91: 89: 83: 82: 78: 77: 74: 70: 69: 68:Franol, others 66: 60: 59: 55: 54: 49: 43: 42: 37: 31: 30: 29:Combination of 15: 13: 10: 9: 6: 4: 3: 2: 6199: 6188: 6185: 6183: 6180: 6178: 6175: 6173: 6170: 6168: 6165: 6163: 6160: 6158: 6155: 6153: 6150: 6148: 6145: 6143: 6140: 6138: 6135: 6134: 6132: 6119: 6118: 6115: 6109: 6102: 6098: 6095: 6092: 6091: 6088: 6085: 6083: 6080: 6078: 6075: 6073: 6070: 6068: 6065: 6063: 6060: 6058: 6055: 6053: 6050: 6048: 6045: 6043: 6040: 6038: 6035: 6033: 6030: 6028: 6025: 6023: 6020: 6018: 6015: 6013: 6010: 6008: 6005: 6003: 6000: 5998: 5995: 5993: 5990: 5988: 5985: 5983: 5980: 5978: 5975: 5973: 5970: 5968: 5965: 5963: 5960: 5957: 5956: 5954: 5950: 5940: 5937: 5935: 5932: 5930: 5927: 5925: 5922: 5920: 5917: 5915: 5912: 5910: 5907: 5906: 5904: 5900: 5894: 5891: 5889: 5886: 5884: 5881: 5879: 5876: 5874: 5873: 5869: 5867: 5864: 5862: 5859: 5857: 5854: 5852: 5849: 5847: 5844: 5842: 5839: 5837: 5834: 5832: 5831: 5827: 5825: 5822: 5820: 5817: 5815: 5814:Benzbromarone 5812: 5810: 5807: 5805: 5802: 5801: 5799: 5794: 5788: 5785: 5781: 5775: 5771: 5761: 5758: 5757: 5755: 5750: 5744: 5738: 5735: 5733: 5730: 5728: 5725: 5723: 5720: 5718: 5715: 5713: 5710: 5708: 5705: 5703: 5700: 5698: 5695: 5693: 5690: 5688: 5685: 5683: 5680: 5679: 5677: 5672: 5666: 5660: 5657: 5655: 5652: 5650: 5647: 5645: 5642: 5640: 5637: 5635: 5632: 5630: 5627: 5625: 5622: 5620: 5617: 5616: 5614: 5609: 5603: 5600: 5596: 5590: 5586: 5572: 5569: 5567: 5564: 5562: 5559: 5557: 5554: 5552: 5549: 5547: 5544: 5542: 5539: 5537: 5534: 5532: 5529: 5527: 5524: 5522: 5519: 5517: 5514: 5512: 5509: 5507: 5504: 5502: 5499: 5497: 5494: 5492: 5489: 5487: 5484: 5482: 5479: 5477: 5474: 5472: 5469: 5467: 5464: 5462: 5459: 5457: 5454: 5452: 5449: 5447: 5446:AR-C 118925XX 5444: 5442: 5439: 5437: 5434: 5432: 5429: 5427: 5424: 5422: 5419: 5417: 5414: 5412: 5409: 5406: 5405: 5402: 5399: 5397: 5394: 5392: 5389: 5387: 5384: 5382: 5379: 5377: 5376:UDP-galactose 5374: 5372: 5369: 5367: 5364: 5362: 5359: 5357: 5354: 5352: 5349: 5347: 5344: 5342: 5339: 5337: 5334: 5332: 5329: 5327: 5324: 5322: 5319: 5317: 5314: 5312: 5309: 5307: 5304: 5302: 5299: 5297: 5294: 5292: 5289: 5287: 5284: 5282: 5279: 5277: 5274: 5272: 5269: 5267: 5264: 5262: 5259: 5257: 5254: 5252: 5249: 5247: 5244: 5242: 5239: 5237: 5234: 5232: 5229: 5227: 5224: 5222: 5219: 5217: 5214: 5212: 5209: 5206: 5205: 5203: 5201: 5197: 5191: 5188: 5186: 5183: 5180: 5179: 5174: 5171: 5169: 5166: 5164: 5161: 5158: 5157: 5152: 5151: 5146: 5143: 5141: 5138: 5136: 5133: 5131: 5128: 5126: 5123: 5121: 5118: 5115: 5114: 5109: 5106: 5104: 5101: 5099: 5096: 5094: 5091: 5089: 5086: 5084: 5081: 5079: 5076: 5074: 5071: 5069: 5066: 5064: 5061: 5059: 5056: 5054: 5051: 5049: 5046: 5044: 5041: 5039: 5036: 5034: 5031: 5029: 5026: 5024: 5021: 5019: 5016: 5014: 5011: 5009: 5006: 5004: 5001: 4999: 4996: 4994: 4991: 4988: 4987: 4982: 4979: 4977: 4974: 4972: 4971:Chelerythrine 4969: 4967: 4966:Calmidazolium 4964: 4962: 4959: 4957: 4954: 4952: 4949: 4947: 4944: 4942: 4939: 4937: 4934: 4932: 4929: 4927: 4924: 4922: 4919: 4917: 4914: 4912: 4909: 4906: 4905: 4902: 4899: 4897: 4894: 4892: 4889: 4887: 4884: 4882: 4879: 4877: 4874: 4872: 4869: 4867: 4864: 4862: 4859: 4857: 4854: 4852: 4851:Cibacron blue 4849: 4847: 4844: 4842: 4839: 4837: 4834: 4832: 4829: 4827: 4824: 4822: 4819: 4817: 4814: 4812: 4809: 4807: 4804: 4802: 4799: 4796: 4795: 4793: 4787: 4780: 4776: 4773: 4770: 4765: 4761: 4755: 4752: 4750: 4747: 4745: 4742: 4740: 4737: 4735: 4732: 4730: 4729:Theodrenaline 4727: 4725: 4722: 4720: 4717: 4715: 4712: 4710: 4707: 4705: 4702: 4700: 4697: 4695: 4692: 4690: 4687: 4685: 4682: 4680: 4677: 4675: 4672: 4670: 4667: 4665: 4664:Proxyphylline 4662: 4660: 4657: 4655: 4652: 4650: 4647: 4645: 4642: 4640: 4637: 4635: 4632: 4630: 4627: 4625: 4622: 4620: 4617: 4615: 4612: 4610: 4607: 4605: 4602: 4600: 4597: 4595: 4592: 4590: 4587: 4585: 4582: 4580: 4577: 4575: 4572: 4570: 4567: 4565: 4562: 4560: 4557: 4555: 4552: 4550: 4547: 4545: 4542: 4540: 4537: 4535: 4532: 4530: 4527: 4525: 4522: 4520: 4517: 4515: 4512: 4510: 4507: 4505: 4502: 4500: 4497: 4495: 4494:Aminophylline 4492: 4490: 4487: 4485: 4482: 4480: 4477: 4475: 4472: 4470: 4467: 4464: 4463: 4460: 4457: 4455: 4452: 4450: 4447: 4445: 4442: 4440: 4437: 4435: 4432: 4430: 4427: 4425: 4422: 4420: 4417: 4415: 4413: 4409: 4407: 4404: 4402: 4399: 4397: 4394: 4392: 4389: 4387: 4384: 4382: 4379: 4377: 4374: 4372: 4369: 4367: 4364: 4362: 4359: 4357: 4354: 4352: 4349: 4347: 4344: 4342: 4339: 4337: 4334: 4332: 4329: 4327: 4325: 4320: 4318: 4315: 4313: 4310: 4308: 4305: 4303: 4301: 4296: 4293: 4292: 4290: 4287: 4282: 4278: 4272: 4269: 4267: 4264: 4261: 4260: 4258: 4255: 4251: 4247: 4244: 4240: 4234: 4230: 4226: 4223: 4216: 4211: 4209: 4204: 4202: 4197: 4196: 4193: 4180: 4179: 4174: 4171: 4170: 4165: 4162: 4161: 4156: 4153: 4152: 4147: 4144: 4143: 4142:Serotonergics 4138: 4135: 4134: 4133:Dopaminergics 4129: 4126: 4125: 4122: 4117: 4116: 4113: 4103: 4100: 4098: 4095: 4093: 4090: 4088: 4085: 4083: 4080: 4078: 4075: 4073: 4070: 4068: 4065: 4063: 4060: 4058: 4055: 4053: 4050: 4048: 4045: 4043: 4040: 4038: 4035: 4033: 4030: 4028: 4025: 4023: 4020: 4018: 4015: 4013: 4010: 4008: 4005: 4003: 4000: 3998: 3995: 3993: 3990: 3988: 3985: 3983: 3980: 3978: 3975: 3973: 3970: 3968: 3965: 3963: 3960: 3958: 3955: 3953: 3950: 3948: 3945: 3943: 3940: 3938: 3935: 3933: 3930: 3928: 3925: 3923: 3920: 3918: 3915: 3913: 3910: 3908: 3905: 3903: 3900: 3898: 3895: 3893: 3890: 3888: 3887:Levobetaxolol 3885: 3883: 3880: 3878: 3875: 3873: 3870: 3868: 3865: 3863: 3860: 3858: 3855: 3853: 3850: 3848: 3845: 3843: 3840: 3838: 3835: 3833: 3830: 3828: 3825: 3823: 3820: 3818: 3815: 3813: 3810: 3808: 3805: 3803: 3800: 3798: 3795: 3793: 3790: 3788: 3785: 3783: 3780: 3778: 3775: 3773: 3770: 3768: 3765: 3763: 3760: 3758: 3755: 3753: 3750: 3748: 3745: 3743: 3740: 3738: 3735: 3733: 3730: 3728: 3727:Cyanopindolol 3725: 3723: 3720: 3718: 3715: 3713: 3710: 3708: 3705: 3703: 3700: 3698: 3695: 3693: 3690: 3688: 3685: 3683: 3680: 3678: 3675: 3673: 3670: 3668: 3665: 3663: 3660: 3658: 3655: 3653: 3650: 3648: 3645: 3643: 3640: 3638: 3635: 3633: 3630: 3628: 3625: 3623: 3620: 3618: 3615: 3613: 3610: 3608: 3605: 3603: 3600: 3598: 3595: 3593: 3590: 3588: 3585: 3583: 3580: 3578: 3575: 3573: 3570: 3568: 3565: 3563: 3560: 3558: 3555: 3553: 3550: 3548: 3545: 3543: 3540: 3538: 3535: 3534: 3532: 3528: 3522: 3519: 3517: 3514: 3512: 3509: 3507: 3504: 3502: 3499: 3497: 3494: 3492: 3489: 3487: 3484: 3482: 3479: 3477: 3474: 3472: 3469: 3467: 3464: 3462: 3459: 3457: 3454: 3452: 3449: 3447: 3444: 3442: 3439: 3437: 3434: 3432: 3429: 3427: 3424: 3422: 3419: 3417: 3414: 3412: 3411:Orciprenaline 3409: 3407: 3404: 3402: 3399: 3397: 3394: 3392: 3389: 3387: 3384: 3382: 3379: 3377: 3374: 3372: 3369: 3367: 3361: 3359: 3353: 3351: 3345: 3343: 3340: 3338: 3335: 3333: 3330: 3328: 3325: 3323: 3320: 3318: 3315: 3313: 3312:Hexoprenaline 3310: 3308: 3305: 3303: 3300: 3298: 3295: 3293: 3290: 3288: 3285: 3283: 3280: 3278: 3275: 3273: 3270: 3268: 3261: 3259: 3256: 3254: 3251: 3249: 3246: 3244: 3241: 3239: 3237: 3232: 3230: 3227: 3225: 3222: 3220: 3217: 3215: 3212: 3210: 3207: 3205: 3202: 3200: 3197: 3195: 3192: 3190: 3187: 3185: 3182: 3180: 3177: 3175: 3172: 3170: 3167: 3165: 3162: 3160: 3157: 3155: 3152: 3150: 3147: 3145: 3142: 3140: 3137: 3136: 3134: 3130: 3127: 3125: 3121: 3111: 3108: 3105: 3101: 3097: 3093: 3089: 3086: 3084: 3081: 3079: 3076: 3074: 3071: 3069: 3066: 3064: 3061: 3059: 3056: 3054: 3051: 3049: 3046: 3044: 3041: 3039: 3036: 3034: 3031: 3029: 3026: 3024: 3021: 3019: 3016: 3014: 3011: 3009: 3006: 3004: 3001: 2999: 2996: 2994: 2991: 2989: 2986: 2984: 2981: 2979: 2976: 2974: 2973:Esmirtazapine 2971: 2969: 2966: 2964: 2961: 2959: 2956: 2954: 2951: 2948: 2944: 2940: 2936: 2932: 2929: 2926: 2922: 2918: 2914: 2910: 2906: 2902: 2898: 2897:brexpiprazole 2894: 2890: 2887: 2885: 2882: 2880: 2877: 2875: 2872: 2870: 2867: 2865: 2862: 2861: 2859: 2855: 2849: 2846: 2844: 2841: 2839: 2836: 2834: 2831: 2829: 2826: 2824: 2821: 2819: 2816: 2814: 2811: 2809: 2806: 2804: 2801: 2799: 2796: 2794: 2791: 2789: 2786: 2784: 2781: 2779: 2776: 2774: 2771: 2769: 2766: 2764: 2763:Oxymetazoline 2761: 2759: 2756: 2754: 2751: 2749: 2746: 2744: 2741: 2739: 2736: 2734: 2731: 2729: 2726: 2724: 2721: 2719: 2716: 2714: 2708: 2706: 2700: 2698: 2692: 2690: 2687: 2685: 2682: 2680: 2677: 2675: 2672: 2670: 2667: 2665: 2662: 2660: 2657: 2655: 2652: 2650: 2643: 2641: 2638: 2636: 2633: 2631: 2628: 2626: 2623: 2621: 2618: 2616: 2614: 2609: 2607: 2604: 2602: 2599: 2597: 2594: 2592: 2591:Apraclonidine 2589: 2587: 2584: 2582: 2579: 2577: 2574: 2572: 2569: 2568: 2566: 2562: 2559: 2557: 2550: 2540: 2537: 2535: 2532: 2530: 2527: 2524: 2520: 2516: 2512: 2508: 2505: 2503: 2500: 2497: 2493: 2489: 2485: 2481: 2480:amitriptyline 2477: 2474: 2471: 2467: 2463: 2459: 2456: 2454: 2451: 2449: 2446: 2444: 2441: 2439: 2436: 2434: 2431: 2429: 2426: 2424: 2421: 2419: 2416: 2414: 2411: 2409: 2406: 2404: 2401: 2399: 2396: 2393: 2392:triazoledione 2389: 2385: 2381: 2377: 2374: 2371: 2369: 2366: 2364: 2361: 2359: 2356: 2354: 2351: 2349: 2346: 2344: 2341: 2339: 2336: 2334: 2331: 2329: 2326: 2324: 2321: 2319: 2316: 2314: 2311: 2309: 2306: 2304: 2301: 2299: 2296: 2294: 2291: 2289: 2286: 2284: 2281: 2279: 2276: 2274: 2271: 2269: 2266: 2264: 2261: 2258: 2254: 2250: 2246: 2242: 2238: 2234: 2231: 2229: 2226: 2224: 2221: 2219: 2216: 2214: 2211: 2209: 2206: 2204: 2201: 2198: 2194: 2190: 2186: 2182: 2178: 2174: 2173:Beta blockers 2171: 2169: 2166: 2163: 2159: 2155: 2151: 2147: 2146:brexpiprazole 2143: 2140: 2138: 2135: 2133: 2130: 2128: 2125: 2123: 2120: 2118: 2115: 2113: 2110: 2109: 2107: 2103: 2097: 2094: 2092: 2089: 2087: 2084: 2082: 2079: 2077: 2074: 2072: 2069: 2067: 2066:Phenylephrine 2064: 2062: 2061:Oxymetazoline 2059: 2057: 2054: 2052: 2049: 2047: 2044: 2042: 2039: 2037: 2034: 2032: 2029: 2027: 2024: 2022: 2019: 2017: 2011: 2009: 2003: 2001: 1995: 1993: 1992:Isometheptene 1990: 1988: 1985: 1983: 1980: 1978: 1975: 1973: 1970: 1968: 1965: 1963: 1960: 1958: 1951: 1949: 1946: 1944: 1941: 1939: 1936: 1934: 1931: 1929: 1927: 1922: 1920: 1917: 1915: 1912: 1910: 1907: 1905: 1902: 1900: 1897: 1896: 1894: 1890: 1887: 1885: 1878: 1874: 1871: 1864: 1859: 1857: 1852: 1850: 1845: 1844: 1841: 1825: 1823: 1820: 1819: 1817: 1814: 1811: 1808: 1806: 1803: 1802: 1798: 1792: 1789: 1787: 1784: 1782: 1779: 1777: 1774: 1772: 1769: 1767: 1764: 1762: 1759: 1757: 1754: 1752: 1749: 1747: 1744: 1742: 1739: 1737: 1734: 1732: 1729: 1727: 1724: 1722: 1719: 1717: 1714: 1712: 1709: 1707: 1704: 1702: 1699: 1698: 1696: 1692: 1686: 1683: 1681: 1678: 1676: 1673: 1671: 1668: 1666: 1663: 1662: 1660: 1656: 1646: 1643: 1641: 1638: 1637: 1635: 1633: 1630:Non-xanthine 1628: 1622: 1619: 1617: 1614: 1613: 1611: 1609: 1605: 1599: 1596: 1595: 1593: 1591: 1587: 1581: 1578: 1576: 1573: 1571: 1568: 1567: 1565: 1563: 1559: 1556: 1553: 1549: 1543: 1540: 1538: 1537:Proxyphylline 1535: 1533: 1532:Etamiphylline 1530: 1528: 1525: 1523: 1520: 1518: 1515: 1513: 1510: 1508: 1507:Aminophylline 1505: 1503: 1500: 1498: 1495: 1494: 1492: 1490: 1486: 1480: 1477: 1475: 1472: 1471: 1469: 1467: 1463: 1457: 1454: 1452: 1449: 1447: 1444: 1442: 1439: 1437: 1434: 1432: 1429: 1428: 1426: 1424: 1419: 1415: 1409: 1408:Triamcinolone 1406: 1404: 1401: 1399: 1396: 1394: 1391: 1389: 1386: 1384: 1381: 1379: 1378:Betamethasone 1376: 1374: 1373:Beclometasone 1371: 1370: 1368: 1366: 1362: 1352: 1349: 1347: 1344: 1342: 1339: 1337: 1334: 1332: 1331:Hexoprenaline 1329: 1327: 1324: 1322: 1319: 1316: 1312: 1308: 1307:+theophylline 1304: 1301: 1300: 1298: 1294: 1288: 1285: 1283: 1280: 1278: 1275: 1273: 1270: 1268: 1265: 1264: 1262: 1260: 1252: 1246: 1243: 1241: 1238: 1236: 1232: 1229: 1227: 1224: 1222: 1219: 1218: 1216: 1214: 1206: 1200: 1197: 1195: 1192: 1190: 1186: 1183: 1181: 1178: 1176: 1173: 1171: 1168: 1166: 1163: 1161: 1158: 1156: 1153: 1151: 1148: 1146: 1143: 1142: 1140: 1138: 1130: 1127: 1125: 1121: 1117: 1112: 1108: 1104: 1100: 1092: 1087: 1085: 1080: 1078: 1073: 1072: 1069: 1059: 1054: 1050: 1046: 1042: 1038: 1034: 1027: 1024: 1019: 1015: 1011: 1004: 1001: 996: 992: 988: 984: 980: 976: 969: 966: 962: 957: 953: 949: 945: 941: 937: 930: 927: 915: 909: 905: 904: 897: 894: 881: 880: 873: 870: 857: 856: 849: 846: 834: 833: 826: 824: 822: 818: 806: 800: 796: 795: 787: 784: 772: 766: 762: 761: 753: 750: 746: 741: 737: 733: 729: 722: 720: 716: 711: 707: 703: 699: 692: 689: 685: 680: 676: 672: 668: 664: 660: 653: 650: 646: 635: 629: 625: 624: 616: 614: 612: 608: 603: 599: 595: 591: 587: 583: 576: 573: 569: 564: 560: 556: 552: 548: 544: 537: 535: 533: 529: 524: 520: 516: 512: 508: 504: 497: 494: 481: 480: 472: 469: 456: 452: 446: 443: 431: 425: 421: 420: 412: 409: 405: 401: 397: 393: 389: 385: 381: 374: 372: 370: 366: 362: 357: 353: 349: 345: 341: 337: 330: 328: 326: 324: 320: 313: 309: 308:Theodrenaline 306: 304: 301: 299: 296: 295: 291: 289: 287: 283: 279: 274: 271: 267: 263: 259: 255: 251: 247: 242: 238: 237:phenobarbital 233: 231: 227: 223: 219: 215: 211: 207: 203: 199: 195: 191: 187: 180: 174: 162: 158: 157: 155: 153: 149: 142: 138: 137: 135: 133: 129: 122: 118: 117: 115: 108: 104: 97: 93: 92: 90: 88: 84: 79: 75: 71: 67: 65: 61: 58:Clinical data 56: 53: 50: 48: 44: 41: 38: 36: 32: 27: 19: 6113: 6112: 6097:Chrysophanol 6093: 6037:Hypoxanthine 5958: 5938: 5934:Pralatrexate 5919:Methotrexate 5914:Azathioprine 5893:Topiroxostat 5870: 5841:Myo-inositol 5828: 5819:Caffeic acid 5732:Progesterone 5702:Dipyridamole 5682:Barbiturates 5659:Progesterone 5441:AR-C 69931MX 5436:AR-C 67085MX 5408:Antagonists: 5407: 5261:AR-C 67085MX 5207: 5176: 5154: 5148: 5111: 5078:Oxidized-ATP 5023:JNJ-47965567 4984: 4908:Antagonists: 4907: 4881:L-β,γ-Me-ATP 4861:D-β,γ-Me-ATP 4797: 4734:Theophylline 4644:Paraxanthine 4589:Fenethylline 4579:Enprofylline 4544:Ciforadenant 4466:Antagonists: 4465: 4429:Piclidenoson 4411: 4323: 4307:2-Cl-IB-MECA 4299: 4294: 4262: 4176: 4167: 4158: 4149: 4140: 4131: 4120: 4119: 3912:Metipranolol 3897:Levomoprolol 3842:Idropranolol 3337:Isoprenaline 3235: 3159:Arformoterol 3104:thioridazine 3096:fluphenazine 3068:Spiroxatrine 3028:Phentolamine 2947:tandospirone 2913:paliperidone 2803:Tasipimidine 2783:Rezatomidine 2728:Medetomidine 2612: 2523:thioridazine 2515:fluphenazine 2496:trimipramine 2484:clomipramine 2368:Phentolamine 2237:acetergamine 2213:Corynanthine 1925: 1775: 1670:Ensifentrine 1542:Theophylline 1527:Enprofylline 1502:Ambuphylline 1474:Cromoglicate 1351:Racephedrine 1235:Arformoterol 1056: 1036: 1032: 1026: 1017: 1013: 1003: 981:(1): 36–43. 978: 974: 968: 959: 939: 935: 929: 917:. Retrieved 902: 896: 884:. Retrieved 878: 872: 860:. Retrieved 854: 848: 837:. Retrieved 831: 808:. Retrieved 793: 786: 774:. Retrieved 759: 752: 743: 731: 727: 701: 697: 691: 682: 662: 658: 652: 643: 637:. Retrieved 622: 585: 581: 575: 566: 546: 542: 509:(1): 15–21. 506: 502: 496: 484:. Retrieved 478: 471: 459:. Retrieved 454: 445: 433:. Retrieved 418: 411: 403: 386:(2): 41–42. 383: 379: 359: 339: 335: 303:Fenethylline 275: 262:butabarbital 254:barbiturates 246:racephedrine 239:(brand name 234: 230:side effects 198:theophylline 189: 185: 172: 171: 35:Theophylline 18: 5959:Precursors: 5939:Many others 5909:Aminopterin 5866:Phytic acid 5809:Amflutizole 5804:Allopurinol 5760:Decynium-22 5717:Hexobendine 5589:Transporter 5566:Ticlopidine 5471:Clopidogrel 5381:UDP-glucose 5120:Purotoxin 1 4951:AZ-11645373 4946:AZ-10606120 4744:Tracazolate 4724:Theobromine 4709:SCH-442,416 4704:Rolofylline 4654:Preladenant 4524:Cartazolate 4504:Bamifylline 4454:Tecadenoson 4449:Sonedenoson 4444:Selodenoson 4439:SDZ WAG 994 4434:Regadenoson 4419:Namodenoson 4371:Capadenoson 4366:Binodenoson 4361:BAY 60–6583 4037:Spirendolol 4012:Propranolol 4007:Propafenone 4002:Pronethalol 3892:Levobunolol 3867:Isoxaprolol 3852:Indopanolol 3837:ICI-118,551 3802:Eugenodilol 3787:Ersentilide 3767:Draquinolol 3762:Diprafenone 3732:Dalbraminol 3712:Cicloprolol 3687:Carpindolol 3672:Butofilolol 3617:Bornaprolol 3562:Alprenoxime 3530:Antagonists 3491:Tulobuterol 3486:Tretoquinol 3481:Terbutaline 3441:Ractopamine 3436:Prenalterol 3342:Isoxsuprine 3327:Indacaterol 3297:Eugenodilol 3287:Etilevodopa 3272:Epinephrine 3263:Droxidopa ( 3243:Dipivefrine 3214:Clenbuterol 3058:Setiptiline 3048:Rauwolscine 3023:Pardoprunox 3013:Mirtazapine 2978:Fenmetozole 2921:risperidone 2884:Atipamezole 2857:Antagonists 2813:Tiamenidine 2808:Tetryzoline 2788:Rilmenidine 2753:Naphazoline 2689:Guanoxabenz 2664:Epinephrine 2654:Etilevodopa 2645:Droxidopa ( 2635:Dipivefrine 2596:Brimonidine 2466:maprotiline 2343:Pardoprunox 2338:Niguldipine 2298:Mepiprazole 2273:Hydroxyzine 2263:Etoperidone 2253:nicergoline 2223:Domesticine 2218:Dapiprazole 2193:eugenodilol 2168:Benoxathian 2162:risperidone 2127:Anisodamine 2105:Antagonists 2086:Tiamenidine 2081:Tetryzoline 2046:Naphazoline 2031:Methoxamine 2026:Metaraminol 1972:Etilevodopa 1962:Epinephrine 1953:Droxidopa ( 1943:Dipivefrine 1904:Amidephrine 1812:from market 1645:Roflumilast 1621:Seratrodast 1580:Zafirlukast 1570:Montelukast 1522:Doxofylline 1512:Bamifylline 1393:Flunisolide 1388:Ciclesonide 1321:Epinephrine 1277:Indacaterol 1226:Clenbuterol 1199:Tulobuterol 1194:Terbutaline 1120:Adrenergics 734:: 103–119. 266:hydroxyzine 258:amobarbital 81:Identifiers 73:Other names 64:Trade names 6131:Categories 5929:Pemetrexed 5888:Tisopurine 5861:Oxipurinol 5856:Niraxostat 5846:Kaempferol 5836:Febuxostat 5780:inhibitors 5692:Cilostazol 5654:Phloridzin 5561:Ticagrelor 5431:AR-C 66096 5291:Diquafosol 5236:α,β-Me-ATP 5221:2-Thio-UTP 5130:Ro 0437626 5083:Phenol Red 4998:Gefapixant 4993:Evans blue 4876:Ivermectin 4806:α,β-Me-ATP 4769:nucleotide 4754:ZM-241,385 4739:Tozadenant 4614:MRE3008F20 4574:Dyphylline 4559:Dimethazan 4489:Acefylline 4459:UK-432,097 4391:Evodenoson 4386:CP-532,903 4346:Apadenoson 4225:modulators 4102:Xipranolol 4092:Toliprolol 4082:Tiprenolol 4067:Tienoxolol 4062:Tertatolol 4047:Sulfinalol 4027:Soquinolol 4022:Ronactolol 3997:Procinolol 3992:Primidolol 3977:Penbutolol 3957:Pacrinolol 3952:Oxprenolol 3947:Nipradilol 3917:Metoprolol 3907:Mepindolol 3902:Medroxalol 3872:Isamoltane 3862:Iprocrolol 3822:Flusoxolol 3812:Falintolol 3792:Esatenolol 3742:Diacetolol 3722:Cloranolol 3702:Celiprolol 3697:Carvedilol 3677:Capsinolol 3662:Butaxamine 3657:Bupranolol 3647:Bunitrolol 3627:Bucindolol 3622:Brefonalol 3612:Bopindolol 3607:Bisoprolol 3602:Bevantolol 3582:Arotinolol 3567:Amosulalol 3557:Alprenolol 3537:Acebutolol 3516:Zilpaterol 3501:Vilanterol 3476:Solabegron 3471:Salmeterol 3466:Salbutamol 3451:Reproterol 3446:Procaterol 3431:Pirbuterol 3416:Oxyfedrine 3401:Mirabegron 3396:Methyldopa 3386:Melevodopa 3376:Lubabegron 3332:Isoetarine 3317:Higenamine 3307:Formoterol 3282:Etilefrine 3277:Etafedrine 3258:Dopexamine 3248:Dobutamine 3229:Denopamine 3224:Corbadrine 3204:Carmoterol 3199:Carbuterol 3189:Broxaterol 3184:Bitolterol 3174:Bambuterol 3164:Arotinolol 3154:Arbutamine 3144:Alifedrine 3139:Abediterol 3083:Tolazoline 3073:Sunepitron 3063:Spegatrine 3053:Rotigotine 2993:Ketanserin 2983:Fluparoxan 2963:Cirazoline 2958:Buflomedil 2943:ipsapirone 2931:Azapirones 2917:quetiapine 2909:olanzapine 2905:lurasidone 2879:Aptazapine 2874:Amesergide 2823:Tolonidine 2818:Tizanidine 2798:Talipexole 2793:Romifidine 2748:Moxonidine 2738:Methyldopa 2733:Melevodopa 2723:Lofexidine 2684:Guanfacine 2669:Etilefrine 2659:Ergotamine 2620:Detomidine 2606:Corbadrine 2502:Trimazosin 2492:imipramine 2453:Tolazoline 2448:Tiodazosin 2438:Tamsulosin 2433:Talipexole 2423:Spegatrine 2408:Quinazosin 2384:nefazodone 2358:Phendioxan 2348:Pelanserin 2333:Niaprazine 2328:Neldazosin 2318:Naftopidil 2313:Moxisylyte 2283:Ketanserin 2268:Fenspiride 2241:ergotamine 2203:Buflomedil 2189:carvedilol 2185:arotinolol 2181:amosulalol 2158:quetiapine 2154:olanzapine 2117:Ajmalicine 2076:Synephrine 2056:Octopamine 2036:Methyldopa 2021:Melevodopa 1987:Indanidine 1967:Etilefrine 1919:Corbadrine 1914:Cirazoline 1873:modulators 1685:Omalizumab 1680:Fenspiride 1616:Ramatroban 1575:Pranlukast 1554:inhibition 1552:Eicosanoid 1497:Acefylline 1479:Nedocromil 1403:Mometasone 1383:Budesonide 1326:Etafedrine 1287:Vilanterol 1282:Olodaterol 1272:Carmoterol 1267:Abediterol 1245:Salmefamol 1240:Salmeterol 1231:Formoterol 1221:Bambuterol 1175:Reproterol 1170:Procaterol 1165:Pirbuterol 1160:Isoetarine 1150:Carbuterol 1145:Bitolterol 1097:Drugs for 839:2024-08-31 639:2024-08-31 380:Prescriber 314:References 161:LMS3EG69X8 132:ChemSpider 96:15766-94-6 87:CAS Number 6187:Xanthines 6114:See also: 6017:Guanosine 5967:Adenosine 5883:Quercetin 5851:Myricetin 5707:Estradiol 5634:Estradiol 5624:Adenosine 5536:Prasugrel 5476:Elinogrel 5466:Cangrelor 5411:2-Me-SAMP 5351:PAPET-ATP 5311:INS-37217 5286:Denufosol 5241:Adenosine 5231:5-OMe-UDP 5216:2-Me-SATP 5211:2-Me-SADP 5208:Agonists: 5103:PSB-12062 5038:Magnesium 5003:GW-791343 4891:PAPET-ATP 4811:Adenosine 4801:2-Me-SATP 4798:Agonists: 4719:Theacrine 4714:SCH-58261 4699:Reversine 4584:Etazolate 4534:CGS-15943 4509:Cafedrine 4381:CGS-21680 4331:Adenosine 4312:2'-MeCCPA 4295:Agonists: 4286:adenosine 4263:Agonists: 4121:See also: 4097:Xibenolol 4087:Tolamolol 4072:Tilisolol 4052:Talinolol 4042:SR 59230A 4017:Ridazolol 3987:Practolol 3967:Pamatolol 3962:Pafenolol 3942:Nifenalol 3937:Nebivolol 3932:Nadoxolol 3882:Landiolol 3877:Labetalol 3847:Indenolol 3817:Flestolol 3807:Exaprolol 3772:Ecastolol 3757:Dilevalol 3717:Cinamolol 3707:Cetamolol 3692:Carteolol 3682:Carazolol 3667:Butidrine 3642:Bufuralol 3637:Bufetolol 3632:Bucumolol 3597:Betaxolol 3592:Befunolol 3572:Ancarolol 3542:Adaprolol 3506:Xamoterol 3461:Ritodrine 3456:Rimiterol 3421:PF-610355 3381:Mabuterol 3366:-Tyrosine 3322:Ibopamine 3302:Fenoterol 3209:Cimaterol 3194:Buphenine 3179:Befunolol 3149:Amibegron 3110:Yohimbine 3078:Terguride 3043:Piribedil 3038:Piperoxan 3008:Mianserin 2953:BRL-44408 2935:buspirone 2901:clozapine 2893:asenapine 2833:Vatinoxan 2773:Piperoxan 2743:Mivazerol 2718:Ibopamine 2713:-Tyrosine 2679:Guanabenz 2601:Clonidine 2539:Zolertine 2470:mianserin 2462:amoxapine 2443:Terazosin 2428:Spiperone 2418:Silodosin 2413:Quinidine 2398:Piperoxan 2388:trazodone 2353:Perlapine 2323:Nantenine 2308:Monatepil 2303:Metazosin 2288:L-765,314 2278:Indoramin 2257:terguride 2233:Ergolines 2228:Doxazosin 2208:Bunazosin 2197:labetalol 2150:clozapine 2137:Atiprosin 2132:Anisodine 2122:Alfuzosin 2112:Abanoquil 2041:Midodrine 2016:-Tyrosine 1982:Ibopamine 1909:Buspirone 1822:Phase III 1810:Withdrawn 1675:Eprozinol 1665:Amlexanox 1640:Ibudilast 1489:Xanthines 1303:Ephedrine 1180:Rimiterol 1155:Fenoterol 1124:inhalants 919:31 August 886:31 August 862:31 August 810:30 August 776:30 August 486:30 August 461:29 August 435:29 August 400:0959-6682 298:Cafedrine 232:however. 224:and as a 206:ephedrine 47:Ephedrine 5992:Cytidine 5987:Cytosine 5878:Propolis 5644:KGO-2173 5639:KGO-2142 5629:dMeThPmR 5595:blockers 5551:Regrelor 5541:PSB-0739 5511:MRS-2578 5506:MRS-2500 5501:MRS-2395 5496:MRS-2279 5491:MRS-2211 5486:MRS-2179 5361:PSB-1114 5356:PSB-0474 5341:MRS-4062 5336:MRS-2957 5331:MRS-2768 5326:MRS-2693 5321:MRS-2690 5316:MRS-2365 5226:5-Br-UDP 5168:TC-P 262 5108:Puerarin 5043:MRS-2159 5018:isoPPADS 4936:A-839977 4931:A-804598 4926:A-740003 4921:A-438079 4916:A-317491 4886:MRS-2219 4749:VUF-5574 4694:PSB-1115 4639:MRS-3777 4634:MRS-1754 4629:MRS-1706 4624:MRS-1334 4619:MRS-1220 4609:KF-26777 4554:CVT-6883 4529:CGH-2466 4514:Caffeine 4406:LUF-5845 4401:LUF-5835 4396:GR 79236 4351:ATL-146e 4233:Receptor 3982:Pindolol 3972:Pargolol 3922:Moprolol 3797:Esprolol 3782:Ericolol 3777:Epanolol 3587:Atenolol 3552:Afurolol 3547:Adimolol 3521:Zinterol 3496:Vibegron 3253:Dopamine 3219:Colterol 3132:Agonists 3100:loxapine 2998:Lisuride 2988:Idazoxan 2968:Efaroxan 2939:gepirone 2925:zotepine 2869:Adimolol 2843:Xylazine 2828:Urapidil 2640:Dopamine 2564:Agonists 2529:Urapidil 2519:loxapine 2403:Prazosin 2249:lisuride 2177:adimolol 1948:Dopamine 1892:Agonists 1598:Zileuton 1259:agonists 1213:agonists 1137:agonists 1053:10984362 1020:: 93–97. 995:33188564 956:17002480 356:23511913 292:See also 282:exercise 256:such as 141:34992091 121:86278139 6101:rhubarb 6094:Others: 6072:Uridine 6042:Inosine 6012:Guanine 5962:Adenine 5712:Ethanol 5697:Dilazep 5649:MeThPmR 5556:Suramin 5461:C1330-7 5306:INS-365 5185:TNP-ATP 5163:Suramin 4961:Calcium 4689:PSB-788 4684:PSB-603 4499:ATL-444 4271:Adenine 4254:adenine 4239:ligands 4077:Timolol 4057:Tazolol 4032:Sotalol 3927:Nadolol 3652:Bunolol 3577:Arnolol 3511:XP21279 3090:(e.g., 3018:NAN-190 2933:(e.g., 2891:(e.g., 2838:XP21279 2586:Amitraz 2534:WB-4101 2509:(e.g., 2488:doxepin 2478:(e.g., 2460:(e.g., 2378:(e.g., 2235:(e.g., 2175:(e.g., 2144:(e.g., 2091:XP21279 740:7002576 679:3534057 602:2019665 563:1092514 107:PubChem 6067:Uracil 6062:Ribose 5952:Others 5902:Others 5774:Enzyme 5521:NF-340 5516:NF-157 5416:A3P5PS 5346:NF-546 5068:NF-449 5063:NF-279 5058:NF-157 5053:NF-110 5048:NF-023 4981:Emodin 4976:Copper 4941:AF-353 4911:5-BDBD 4871:HT-AMP 4679:PSB-36 4674:PSB-11 4669:PSB-10 3267:-DOPS) 2649:-DOPS) 2576:4-NEMD 1957:-DOPS) 1805:WHO-EM 1103:asthma 1051:  993:  954:  910:  801:  767:  738:  708:  677:  630:  600:  561:  523:350932 521:  426:  398:  354:  286:sports 241:Tedral 222:asthma 204:, and 190:Franol 184:), or 5722:NBMPR 5531:PPADS 5456:BzATP 5421:AMPαS 5401:UTPγS 5371:UDPβS 5271:ATPγS 5251:ADPβS 5135:Ro 51 5098:PPNDS 5093:PPADS 5033:KN-62 5028:KN-04 4846:BzATP 4841:ATPγS 4569:DPCPX 2581:6-FNE 1899:6-FNE 1296:Other 710:35721 270:Marax 200:, an 5748:PMAT 5670:ENTs 5607:CNTs 5546:RB-2 5481:Ip5I 5426:Ap4A 5391:Up3U 5281:dATP 5256:Ap3A 5190:Zinc 5140:RO-3 5125:RB-2 5013:Ip5I 4901:Zinc 4831:Ap5A 4826:Ap4A 4594:IBMX 4564:DMPX 4376:CCPA 3169:BAAM 3003:mCPP 2864:1-PP 2778:PS75 2293:mCPP 1107:COPD 1049:PMID 991:PMID 952:PMID 921:2024 908:ISBN 888:2024 864:2024 812:2024 799:ISBN 778:2024 765:ISBN 736:PMID 706:PMID 675:PMID 628:ISBN 598:PMID 559:PMID 519:PMID 488:2024 463:2024 437:2024 424:ISBN 396:ISSN 352:PMID 284:and 260:and 248:and 208:, a 152:UNII 6087:UTP 6082:UDP 6077:UMP 6057:ITP 6052:IDP 6047:IMP 6032:GTP 6027:GDP 6022:GMP 6007:CTP 6002:CDP 5997:CMP 5982:ATP 5977:ADP 5972:AMP 5571:UDP 5526:PIT 5451:ATP 5396:UTP 5366:UDP 5301:ITP 5296:IDP 5276:CTP 5266:ATP 5246:ADP 5200:P2Y 5008:HMA 4956:BBG 4896:UTP 4866:GTP 4856:CTP 4836:ATP 4821:AMP 4816:ADP 4785:ATP 4779:P2X 4549:CPX 4356:ATP 4341:AMP 4336:ADP 4322:5'- 1111:R03 1041:doi 1037:106 983:doi 944:doi 732:109 667:doi 590:doi 551:doi 511:doi 388:doi 344:doi 280:in 196:of 178:INN 111:CID 6133:: 5792:XO 5153:, 4764:P2 4281:P1 4250:P0 3102:, 3098:, 3094:, 2945:, 2941:, 2937:, 2923:, 2919:, 2915:, 2911:, 2907:, 2903:, 2899:, 2895:, 2521:, 2517:, 2513:, 2494:, 2490:, 2486:, 2482:, 2468:, 2464:, 2390:, 2386:, 2382:, 2255:, 2251:, 2247:, 2243:, 2239:, 2195:, 2191:, 2187:, 2183:, 2179:, 2160:, 2156:, 2152:, 2148:, 1818:: 1313:, 1309:, 1122:, 1101:: 1055:. 1047:. 1035:. 1016:. 1012:. 989:. 979:13 977:. 958:. 950:. 940:24 938:. 820:^ 742:. 730:. 718:^ 702:63 700:. 681:. 673:. 663:78 661:. 642:. 610:^ 596:. 586:31 584:. 565:. 557:. 547:17 545:. 531:^ 517:. 507:62 505:. 453:. 402:. 394:. 384:33 382:. 368:^ 358:. 350:. 338:. 322:^ 6103:) 6099:( 5782:) 5778:( 5597:) 5593:( 5181:) 5175:( 5159:) 5147:( 5116:) 5110:( 4989:) 4983:( 4791:) 4782:( 4771:) 4767:( 4412:N 4324:N 4300:N 4288:) 4284:( 4256:) 4252:( 4241:) 4237:( 4214:e 4207:t 4200:v 3364:L 3356:L 3348:L 3265:L 3236:N 3124:β 3106:) 2949:) 2927:) 2711:L 2703:L 2695:L 2647:L 2613:N 2555:2 2553:α 2525:) 2498:) 2472:) 2394:) 2259:) 2199:) 2164:) 2014:L 2006:L 1998:L 1955:L 1926:N 1883:1 1881:α 1862:e 1855:t 1848:v 1420:/ 1317:) 1305:( 1257:2 1233:/ 1211:2 1187:/ 1135:2 1113:) 1109:( 1105:/ 1090:e 1083:t 1076:v 1043:: 1018:3 997:. 985:: 946:: 923:. 890:. 866:. 842:. 814:. 780:. 712:. 669:: 604:. 592:: 553:: 525:. 513:: 490:. 465:. 439:. 390:: 346:: 340:2 175:(

Index

Theophylline
Adenosine receptor antagonist
Ephedrine
Norepinephrine releasing agent
Trade names
CAS Number
15766-94-6
PubChem
86278139
ChemSpider
34992091
UNII
LMS3EG69X8
INN
combination formulation
theophylline
adenosine receptor antagonist
ephedrine
norepinephrine releasing agent
sympathomimetic agent
bronchodilator
asthma
nasal decongestant
side effects
phenobarbital
Tedral
racephedrine
pseudoephedrine
barbiturates
amobarbital

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