33:
344:) as the prototypic non-catalytic interaction module. SH2 domains serve as a model for a large family of protein modules that act together to control many aspects of cellular signalling. Since the discovery of SH2 domains, hundreds of different modules have been identified in many proteins.
936:
Henkemeyer, M.; Marengere, L. E.; McGlade, J.; Olivier, J. P.; Conlon, R. A.; Holmyard, D. P.; Letwin, K.; Pawson, T. (1994). "Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis".
795:
Nash, P.; Tang, X.; Orlicky, S.; Chen, Q.; Gertler, F. B.; Mendenhall, M. D.; Sicheri, F.; Pawson, T.; Tyers, M. (2001). "Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication".
908:
Salcini, A. E.; McGlade, J.; Pelicci, G.; Nicoletti, I.; Pawson, T.; Pelicci, P. G. (1994). "Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins".
1013:
Crowe, A. J.; McGlade, J.; Pawson, T.; Hayman, M. J. (1994). "Phosphorylation of the SHC proteins on tyrosine correlates with the transformation of fibroblasts and erythroblasts by the v-sea tyrosine kinase".
2831:
1041:
Marengere, L. E. M.; Songyang, Z.; Gish, G. D.; Schaller, M. D.; Parsons, J. T.; Stern, M. J.; Cantley, L. C.; Pawson, T. (1994). "SH2 domain specificity and activity modified by a single residue".
2861:
847:
Holland, S. J.; Gale, N. W.; Mbamalu, G.; Yancopoulos, G. D.; Henkemeyer, M.; Pawson, T. (1996). "Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands".
2846:
646:
576:
425:"for his discovery of protein domains essential for mediating protein-protein interactions in cellular signaling pathways, and the insights this research has provided into cancer"
2866:
2497:
340:, the molecular mechanisms by which cells respond to external cues, and how they communicate with each other. He identified the phosphotyrosine-binding Src homology 2 (
1335:
468:, candidate for Nobel Prize in Medicine "for identification of the phosphotyrosine binding SH2 domain and demonstrating its function in protein-protein interactions"
2821:
439:
2891:
2786:
384:
2796:
2791:
555:
2836:
1279:
664:
2871:
1776:
2856:
2841:
354:
127:
2851:
2816:
690:
2881:
2826:
416:
263:
2806:
1328:
1308:
2291:
1298:
314:
201:
2480:
465:
303:
631:
235:
2315:
1321:
1242:
626:
2886:
2563:
318:
307:
197:
2811:
2682:
1769:
2876:
2801:
2309:
1430:
409:
2489:
2250:
2048:
1580:
256:
162:
1258:
2677:
2613:
396:
1163:"Tony (Anthony James) Pawson, a giant in the field of cell signaling research, dies unexpectedly at the age of 60"
966:"Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses"
295:
2707:
2428:
2214:
1762:
291:
96:
299:
100:
2516:
2410:
2196:
433:
364:
360:
280:
2149:
1294:
2645:
2473:
2089:
1947:
1708:
1406:
1345:
751:
448:
422:
141:
2434:
2167:
504:"Anthony James Pawson (1952–2013) Biochemist whose vision of cell signalling transformed cancer research"
461:– "Japan's Nobel" for "Proposing and Proving the Concept of Adapter Molecules in the Signal Transduction"
2657:
2568:
1823:
742:
Pawson, T.; Nash, P. (2003). "Assembly of Cell
Regulatory Systems Through Protein Interaction Domains".
452:
370:
322:
193:
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1422:
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1050:
856:
805:
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2107:
756:
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2143:
2012:
1845:
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400:
337:
117:
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1511:
1412:
1359:
1084:
995:
890:
829:
777:
581:
560:
389:
1998 The Royal
Society of Canada Flavelle Medal for meritorious achievement in biological science
287:
2368:
964:
Stephens, R. M.; Loeb, D. M.; Copeland, T. D.; Pawson, T.; Greene, L. A.; Kaplan, D. R. (1994).
2458:
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987:
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882:
821:
769:
533:
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2697:
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2583:
2558:
2321:
2018:
2006:
1976:
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1685:
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1507:
1184:
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1133:
1123:
1066:
1058:
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761:
523:
249:
214:
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2422:
2398:
2327:
2274:
2238:
2226:
2220:
2137:
2113:
2101:
2060:
2054:
1935:
1911:
1785:
1712:
1647:
1641:
1635:
1631:
1574:
1472:
1313:
1104:"Src Homology Region 2 Domains Direct Protein-Protein Interactions in Signal Transduction"
242:
1119:
1054:
860:
809:
519:
2702:
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2588:
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2256:
2119:
2077:
1994:
1982:
1964:
1941:
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1811:
1799:
1679:
1584:
1570:
1495:
1489:
1442:
1377:
1189:
1162:
495:
380:
134:
717:
283:, and botanist and high-school teacher Hilarie. He was the eldest of three children.
2770:
2745:
2608:
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2404:
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2202:
2155:
2083:
1988:
1905:
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1655:
1556:
1501:
1458:
1138:
1103:
982:
965:
499:
1204:
1088:
833:
781:
471:
2013 Annual award of the
Canadian National Proteomics Network, thereafter named the
2755:
2672:
2603:
2511:
2416:
2386:
2362:
2350:
2042:
2036:
2024:
1970:
1929:
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1608:
1604:
1529:
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1452:
1367:
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1234:
999:
894:
183:
267:(18 October 1952 – 7 August 2013) was a British-born Canadian genetic scientist.
2750:
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2125:
2095:
2000:
1899:
1851:
1718:
1651:
1539:
1468:
458:
429:
155:
148:
313:
Pawson was a
Distinguished Investigator and former Director of Research at the
2692:
2573:
2356:
2232:
2208:
1875:
1863:
1829:
1533:
665:"Renowned Toronto genetic researcher Dr. Tony Pawson dies | Toronto Star"
341:
2184:
1402:
1179:
1128:
765:
276:
57:
32:
1262:
825:
773:
537:
2713:
2651:
2639:
2552:
1147:
1080:
1027:
991:
950:
922:
886:
691:"Scientific community reels at the loss of the world-renowned Tony Pawson"
405:
2004 Poulsson Medal, the
Norwegian Society of Pharmacology and Toxicology
179:
1303:
1261:. Canadian Institutes of Health Research. 17 April 2007. Archived from
306:. From 1981 to 1985, he was Assistant Professor in microbiology at the
76:
577:"Anthony Pawson helped discover how cells communicate with each other"
1071:
1062:
877:
868:
817:
328:
Pawson died on 7 August 2013 of unspecified causes at the age of 60.
208:
556:"Anthony Pawson, Biologist in Cell-Protein Breakthrough, Dies at 60"
528:
503:
1754:
2462:
1758:
1317:
302:
in 1976. From 1976 to 1980 he pursued postdoctoral work at the
215:
Studies on the
Proteins and Nucleic Acids of RNA Tumour Viruses
105:
321:
and
Professor in the Department of Molecular Genetics at the
376:
1998 Pezcoller-AACR International Award for Cancer
Research
1280:"Renowned Toronto genetic researcher Dr. Tony Pawson dies"
2832:
Foreign associates of the
National Academy of Sciences
627:"Tony Pawson, renowned Canadian scientist, dies at 60"
279:, England. He was the son of the sportsman and writer
2862:
Academic staff of the
University of British Columbia
392:
2000 J. Allyn Taylor International Prize in Medicine
2723:
2504:
2343:
2284:
2177:
2070:
1957:
1792:
1701:
1618:
1549:
1482:
1391:
1352:
207:
189:
175:
123:
113:
92:
84:
65:
39:
23:
1235:"Professor named to Order of Companions of Honour"
2847:Members of the Order of the Companions of Honour
1304:The Official Site of Louisa Gross Horwitz Prize
1108:Proceedings of the National Academy of Sciences
440:Member of the Order of the Companions of Honour
336:Pawson's research changed the understanding of
385:Royal Netherlands Academy of Arts and Sciences
2474:
1770:
1329:
8:
1259:"Anthony Pawson – OC, O.Ont, PhD, FRS, FRSC"
490:
488:
373:from the National Cancer Institute of Canada
2867:Academic staff of the University of Toronto
1309:Online Publications (University of Toronto)
549:
547:
2481:
2467:
2459:
1777:
1763:
1755:
1336:
1322:
1314:
31:
20:
1188:
1178:
1137:
1127:
1070:
981:
876:
755:
527:
605:"Retrospective Tony Pawson (1952–2013)"
484:
355:Gairdner Foundation International Award
298:in biochemistry followed by a PhD from
128:Gairdner Foundation International Award
2822:Fellows of the Royal Society of Canada
1245:from the original on 15 September 2007
2892:Canadian fellows of the Royal Society
2787:People educated at Winchester College
417:American Academy of Arts and Sciences
7:
1209:Canadian National Proteomics Network
1299:Samuel Lunenfeld Research Institute
315:Samuel Lunenfeld Research Institute
202:Samuel Lunenfeld Research Institute
2792:Alumni of Clare College, Cambridge
466:Thomson Reuters Citation Laureates
304:University of California, Berkeley
14:
2837:Kyoto laureates in Basic Sciences
473:CNPN-Tony Pawson Proteomics Award
383:for Biochemistry and Biophysics,
325:both of which he joined in 1985.
2872:Wolf Prize in Medicine laureates
1167:Cell Communication and Signaling
554:Vitello, Paul (29 August 2013).
2857:Officers of the Order of Canada
2842:Members of the Order of Ontario
2797:Alumni of King's College London
1295:Anthony Pawson official website
16:British-born Canadian scientist
651:University of Toronto Magazine
575:Buck, Genna (14 August 2013).
308:University of British Columbia
1:
2852:Winners of the Heineken Prize
2817:Canadian molecular biologists
647:"In Memoriam: Anthony Pawson"
432:(The Queen's Medal) from The
198:Mount Sinai Hospital, Toronto
2882:English molecular biologists
2827:Fellows of the Royal Society
1278:Laura Kane (8 August 2013).
1233:Elaine Smith (5 July 2006).
983:10.1016/0896-6273(94)90223-2
716:Paul Wells (9 August 2013).
449:Howard Taylor Ricketts Award
410:National Academy of Sciences
118:Cellular signal transduction
2807:English emigrants to Canada
2741:Isaak Markovich Khalatnikov
1793:Biochemistry and Biophysics
1161:Feller, Stephan M. (2013).
163:Fellow of the Royal Society
2908:
444:2007 Premiers Summit Award
397:Louisa Gross Horwitz Prize
1241:. University of Toronto.
225:
168:
30:
292:Clare College, Cambridge
97:Clare College, Cambridge
2553:Henry Marshall Charlton
1180:10.1186/1478-811X-11-61
1129:10.1073/pnas.87.21.8622
766:10.1126/science.1083653
434:Royal Society of London
365:Royal Society of Canada
361:Royal Society of London
294:, where he received an
2090:BirdLife International
2071:Environmental Sciences
1723:Lynne Elizabeth Maquat
1709:Emmanuelle Charpentier
1346:Wolf Prize in Medicine
423:Wolf Prize in Medicine
408:2004 Associate of the
142:Wolf Prize in Medicine
2887:People from Maidstone
2714:James Gordon Williams
2658:Andrew Clennel Palmer
2569:Nicholas Barry Davies
1102:Moran, M. F. (1990).
453:University of Chicago
371:Robert L. Noble Prize
323:University of Toronto
300:King's College London
194:University of Toronto
101:King's College London
2812:Canadian biochemists
2736:Friedrich Hirzebruch
2594:Michael J. C. Gordon
1561:Alexander Varshavsky
1463:Elizabeth F. Neufeld
1423:Jean-Pierre Changeux
1417:Stanley Norman Cohen
1205:"Past award winners"
319:Mount Sinai Hospital
232:Anthony James Pawson
44:Anthony James Pawson
2877:Royal Medal winners
2802:English biochemists
2640:Robert Michael Moor
2547:Anthony Butterworth
1692:Jeffrey M. Friedman
1518:Stanley B. Prusiner
1265:on 15 February 2005
1120:1990PNAS...87.8622M
1055:1994Natur.369..502M
861:1996Natur.383..722H
810:2001Natur.414..514N
520:2013Natur.501..168B
415:2004 Member of the
401:Columbia University
359:1994 Fellow of the
338:signal transduction
286:He was educated at
275:Pawson was born in
2652:John Forster Nixon
1670:Jeffrey V. Ravetch
1591:Alexander Levitzki
1512:Yasutomi Nishizuka
1413:Barbara McClintock
1282:. The Toronto Star
653:. 1 December 2013.
603:Kyriakis, John M.
582:The Globe and Mail
561:The New York Times
348:Honours and awards
288:Winchester College
2764:
2763:
2683:David Sherrington
2579:George Efstathiou
2537:Geoffrey Boxshall
2532:Richard Borcherds
2456:
2455:
2285:Cognitive Science
1752:
1751:
1733:Daniel J. Drucker
1595:Anthony R. Hunter
1567:Ralph L. Brinster
1449:Pedro Cuatrecasas
1437:Donald F. Steiner
1427:Solomon H. Snyder
1382:Oleh Hornykiewicz
1344:Laureates of the
1114:(21): 8622–8626.
1049:(6480): 502–505.
917:(10): 2827–2836.
855:(6602): 722–725.
804:(6863): 514–521.
750:(5618): 445–452.
718:"RIP Tony Pawson"
229:
228:
170:Scientific career
2899:
2731:F. Albert Cotton
2698:Richard Treisman
2599:Dennis Greenland
2584:John Edwin Field
2559:Anthony Cheetham
2483:
2476:
2469:
2460:
2150:Sinninghe Damsté
1779:
1772:
1765:
1756:
1743:José-Alain Sahel
1686:James P. Allison
1676:Lewis C. Cantley
1666:Philippa Marrack
1508:Michael Berridge
1338:
1331:
1324:
1315:
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1289:
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1201:
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1194:
1192:
1182:
1158:
1152:
1151:
1141:
1131:
1099:
1093:
1092:
1074:
1063:10.1038/369502a0
1038:
1032:
1031:
1010:
1004:
1003:
985:
961:
955:
954:
945:(4): 1001–1014.
933:
927:
926:
905:
899:
898:
880:
869:10.1038/383722a0
844:
838:
837:
818:10.1038/35107009
792:
786:
785:
759:
739:
733:
732:
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707:
706:
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687:
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661:
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654:
643:
637:
636:
635:. 9 August 2013.
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109:
88:British-Canadian
72:
53:
51:
35:
21:
2907:
2906:
2902:
2901:
2900:
2898:
2897:
2896:
2767:
2766:
2765:
2760:
2719:
2688:Fraser Stoddart
2629:Peter McCullagh
2619:David MacLennan
2500:
2487:
2457:
2452:
2339:
2280:
2173:
2066:
1953:
1788:
1786:Heineken Prizes
1783:
1753:
1748:
1713:Jennifer Doudna
1697:
1648:Nahum Sonenberg
1642:Ronald M. Evans
1636:Rudolf Jaenisch
1632:Shinya Yamanaka
1614:
1581:Robert Weinberg
1575:Oliver Smithies
1545:
1478:
1473:Edward B. Lewis
1407:James L. Gowans
1387:
1368:Jon J. van Rood
1348:
1342:
1285:
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846:
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841:
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793:
789:
757:10.1.1.321.3136
741:
740:
736:
726:
724:
715:
714:
710:
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698:
697:. 9 August 2013
689:
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671:. 8 August 2013
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529:10.1038/501168a
496:Bernstein, Alan
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93:Alma mater
80:
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61:
55:
54:18 October 1952
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5:
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2718:
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2710:
2705:
2703:Scott Tremaine
2700:
2695:
2690:
2685:
2680:
2678:Derek Robinson
2675:
2670:
2665:
2663:David Pettifor
2660:
2655:
2648:
2643:
2636:
2631:
2626:
2621:
2616:
2614:Andrew Lumsden
2611:
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2601:
2596:
2591:
2589:Graham Fleming
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2542:Jeremy Brockes
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2429:Van Oldenborgh
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2016:
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1730:
1727:Adrian Krainer
1716:
1705:
1703:
1699:
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1696:
1695:
1689:
1683:
1680:C. Ronald Kahn
1673:
1659:
1645:
1639:
1629:
1622:
1620:
1616:
1615:
1613:
1612:
1602:
1588:
1585:Roger Y. Tsien
1578:
1571:Mario Capecchi
1564:
1553:
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1739:Botond Roska
1662:John Kappler
1626:Axel Ullrich
1609:Aharon Razin
1605:Howard Cedar
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1530:Michael Sela
1524:Mary F. Lyon
1453:Meir Wilchek
1374:Roger Sperry
1364:Jean Dausset
1360:George Snell
1284:. Retrieved
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1267:. Retrieved
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2777:1952 births
2751:Erwin Neher
2668:Tony Pawson
2634:Dusa McDuff
2624:Tak Wah Mak
2522:Nick Barton
2245:McKitterick
2191:Van der Wee
1719:Joan Steitz
1652:Gary Ruvkun
1599:Tony Pawson
1540:Eric Kandel
1469:John Gurdon
669:Thestar.com
459:Kyoto Prize
430:Royal Medal
281:Tony Pawson
156:Kyoto Prize
149:Royal Medal
85:Nationality
25:Tony Pawson
2771:Categories
2693:John Tooze
2574:Guy Dodson
2399:Van Golden
2316:McClelland
2132:Brunekreef
2061:Deisseroth
1983:Montagnier
1824:Van Deenen
1534:Ruth Arnon
611:16 January
479:References
342:SH2 domain
50:1952-10-18
2708:Bob White
2423:Struycken
2411:B. Visser
2405:Koelewijn
2363:C. Visser
2328:Kanwisher
2304:Tomasello
2221:Schilling
2108:Harremoës
2055:Carmeliet
2013:Blackburn
1965:Lauterbur
1846:Reichardt
1836:Weissmann
1403:Leo Sachs
1239:news@UofT
1072:1807/9433
878:1807/9444
752:CiteSeerX
727:10 August
722:Maclean's
701:10 August
695:Maclean's
428:2005 The
277:Maidstone
271:Biography
79:, Ontario
60:, England
58:Maidstone
2496:elected
2292:Anderson
2215:De Vries
2168:Le Quéré
2144:Laurance
2114:Thompson
2078:Lovelock
2031:Steinman
1995:Marshall
1971:Van Rood
1958:Medicine
1948:Stillman
1924:De Lange
1906:Jeffreys
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1800:Chargaff
1577:(2002/3)
1526:(1996/7)
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1286:8 August
1243:Archived
1089:22767669
1016:Oncogene
939:Oncogene
911:Oncogene
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782:14634947
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675:9 August
538:24025833
502:(2013).
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332:Research
180:Genetics
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2498:in 1994
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2351:Verhoef
2334:Zatorre
2298:Dehaene
2269:McNeill
2257:Assmann
2227:Le Goff
2203:Oberman
2178:History
2102:Ehrlich
2084:Branica
2049:Jackson
2043:Alitalo
2037:Clevers
1989:De Wied
1977:Moncada
1912:Szostak
1888:Rothman
1818:De Duve
1806:Brachet
1297:at the
1214:16 July
1190:3766090
1148:2236073
1116:Bibcode
1081:7515480
1051:Bibcode
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1000:7053584
992:8155326
951:8134103
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895:4349898
887:8878483
857:Bibcode
806:Bibcode
744:Science
516:Bibcode
77:Toronto
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2003:(2000)
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1938:(2016)
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1187:
1173:: 61.
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1136:
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1079:
1043:Nature
1026:
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970:Neuron
949:
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220:(1976)
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176:Fields
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131:(1994)
124:Awards
2233:Mokyr
2209:Ozouf
2197:Brown
2120:Levin
1918:Hartl
1894:Tsien
1876:Nurse
1864:Borst
1858:Leder
1702:2020s
1619:2010s
1550:2000s
1483:1990s
1392:1980s
1353:1970s
1139:55009
1085:S2CID
996:S2CID
891:S2CID
830:S2CID
778:S2CID
588:5 May
464:2012
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451:from
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2019:King
1900:Fire
1852:Cech
1830:Klug
1288:2013
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1144:PMID
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1024:PMID
988:PMID
947:PMID
919:PMID
883:PMID
822:PMID
770:PMID
729:2013
703:2013
677:2013
613:2015
590:2014
534:PMID
412:(US)
290:and
264:FRSC
250:OOnt
66:Died
40:Born
2393:Mik
2357:Bot
2344:Art
2185:Gay
1185:PMC
1175:doi
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1124:doi
1067:hdl
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978:doi
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317:of
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106:PhD
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