46:
406:(TTV) isolate, was accidental. After TTV was isolated in 1997 from a Japanese patient, primers were created to study TTV in more detail. TTV-specific primers used in PCR of human plasma samples yielded sequences that partially matched that of TTV, but were noticeably shorter. TTV was eventually understood to have a genome of 3.6–3.9 kb, while TTMV has a genome of 2.8–2.9 kb. Another TT-like virus later isolated in 2007,
422:
The genome is circular and made of single-stranded DNA of negative polarity. It is 2.86–2.91 kilobases long. Anelloviruses are known for having 3 or 4 overlapping, nested open reading frames; TTMV has 3 ORF's that overlap. ORF-2 and ORF-3 overlap with ORF-1 at opposite ends. For TTMV, ORF-1 is about
435:
TTMV is also highly prevalent, like other human anelloviruses. Subsequent research after it was discovered has yielded the prevalence of TTMV DNA among blood donors to be 48%–72%. It can likely infect a wide range of tissues, as it has been isolated from various body fluids and tissues, including
418:
TTMV shares similar morphologic features with the other human anelloviruses. The capsid has a T=1 icosahedral symmetry. The virion does not have a lipid envelope and is thus "naked", making it an extremely simple virus. It is estimated that the virion is a little less than 30 nm in diameter.
451:
Though TTVs are potentially associated with dieases and their pathogenicity has been debated since their discovery, TTMV is not currently known as an explicit cause of any human disease. TTMV has been isolated from a number of parapneumonic
440:, bone marrow, spleen, pancreas, kidneys, nervous tissue, lymph nodes, semen, and cervical swabs. Its exact transmission mechanism is unknown, but is thought to be possible by blood-borne, sexual, fecal-oral, and respiratory routes.
672:
Galmès J, Li Y, Rajoharison A, Ren L, Dollet S, Richard N, Vernet G, Javouhey E, Wang J, Telles JN, Paranhos-Baccalà G (2012) Potential implication of new torque teno mini viruses in parapneumonic empyema in children. Eur Respir
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TTMV is highly divergent. The first phylogenetic tree created from TTMV genomic sequences revealed a large cluster of strains; ORF-1 had divergences of over 42% at the nucleotide level and over 67% at the amino acid level.
808:
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663 residues and ORF-2 is about 91 residues long. There is a highly conserved 130-nt region just downstream of the TATA box.
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618:"A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients"
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Spandole, Sonia; Cimponeriu, Dănuţ; Berca, Lavinia
Mariana; Mihăescu, Grigore (April 2015).
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includes all "torque teno mini viruses" (TTMV), numbered from 1 to 38 as 38 species.
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518:"Human anelloviruses: an update of molecular, epidemiological and clinical aspects"
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Recent studies have shown that humans can have multiple infections of TT viruses.
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576:. Current Topics in Microbiology and Immunology. Vol. 331. pp. 1–20.
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Okamoto, H (2009). "History of
Discoveries and Pathogenicity of TT Viruses".
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476:. International Committee on Taxonomy of Viruses (ICTV). March 2021
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456:. However, its clinical significance remains unclear.
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402:The discovery of TTMV, like the original
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410:or TTMDV, has a genome of 3.2 kb.
110:II in the Baltimore classification
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474:"Virus Taxonomy: 2020 Release"
1:
436:saliva, feces, plasma/serum,
582:10.1007/978-3-540-70972-5_1
884:
712:ViralZone: Betatorquevirus
616:Zhang, Yu (May 6, 2016).
535:10.1007/s00705-015-2363-9
390:Torque teno mini virus 38
383:Torque teno mini virus 37
376:Torque teno mini virus 36
369:Torque teno mini virus 35
362:Torque teno mini virus 34
355:Torque teno mini virus 33
348:Torque teno mini virus 32
341:Torque teno mini virus 31
334:Torque teno mini virus 30
327:Torque teno mini virus 29
320:Torque teno mini virus 28
313:Torque teno mini virus 27
306:Torque teno mini virus 26
299:Torque teno mini virus 25
292:Torque teno mini virus 24
285:Torque teno mini virus 23
278:Torque teno mini virus 22
271:Torque teno mini virus 21
264:Torque teno mini virus 20
257:Torque teno mini virus 19
250:Torque teno mini virus 18
243:Torque teno mini virus 17
236:Torque teno mini virus 16
229:Torque teno mini virus 15
222:Torque teno mini virus 14
215:Torque teno mini virus 13
208:Torque teno mini virus 12
201:Torque teno mini virus 11
194:Torque teno mini virus 10
39:
32:
701:Medical Subject Headings
687:ICTV Virus Taxonomy 2009
187:Torque teno mini virus 9
180:Torque teno mini virus 8
173:Torque teno mini virus 7
166:Torque teno mini virus 6
159:Torque teno mini virus 5
152:Torque teno mini virus 4
145:Torque teno mini virus 3
138:Torque teno mini virus 2
131:Torque teno mini virus 1
427:Phylogeny & spread
408:Torque teno midi virus
18:Torque Teno Mini virus
522:Archives of Virology
41:Virus classification
634:2016NatSR...626739Z
622:Scientific Reports
850:
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723:Taxon identifiers
642:10.1038/srep26739
591:978-3-540-70971-8
414:Genome and capsid
404:Torque Teno virus
398:Initial discovery
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54:(unranked):
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755:Wikispecies
697:Anellovirus
108:, in group
857:Categories
574:TT Viruses
460:References
801:10017968
788:11602507
746:Q4897367
740:Wikidata
660:27221159
600:19230554
544:25680568
447:Clinical
120:Taxonomy
64:Family:
814:1452761
651:4879676
630:Bibcode
454:empyema
100:viruses
76:Genus:
840:600197
827:687332
707:ICTVdb
703:(MeSH)
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480:23 May
835:WoRMS
809:IRMNG
438:PBMCs
96:genus
94:is a
58:Virus
822:NCBI
796:GBIF
775:39WB
656:PMID
596:PMID
586:ISBN
540:PMID
482:2021
783:EoL
770:CoL
646:PMC
638:doi
578:doi
530:doi
526:160
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