126:
2686:
Lallet S, Garreau H, Garmendia-Torres C, Szestakowska D, Boy-Marcotte E, Quevillon-Chéruel S, Jacquet M (Oct 2006). "Role of Gal11, a component of the RNA polymerase II mediator in stress-induced hyperphosphorylation of Msn2 in
Saccharomyces cerevisiae".
2806:
Thakur JK, Arthanari H, Yang F, Pan SJ, Fan X, Breger J, Frueh DP, Gulshan K, Li DK, Mylonakis E, Struhl K, Moye-Rowley WS, Cormack BP, Wagner G, Näär AM (Apr 2008). "A nuclear receptor-like pathway regulating multidrug resistance in fungi".
240:. Positions 1, 3-4, and 7 of the 9aaTAD are the main residues that interact with KIX. Interactions of Gal4, Pdr1 and Gcn4 with Taf9 have been observed. 9aaTAD is a common transactivation domain which recruits multiple general coactivators
161:
in mammals. The definition largely overlaps with an "acidic" family definition. A 9aaTAD prediction tool is available. 9aaTADs tend to have an associated 3-aa hydrophobic (usually Leu-rich) region immediately to its N-terminal.
1566:"Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain"
2271:
Kim YJ, Björklund S, Li Y, Sayre MH, Kornberg RD (May 1994). "A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II".
117:
Alternatively, since similar amino acid compositions does not necessarily mean similar activation pathways, TADs can be grouped by the process they stimulate, either initiation or elongation.
2228:
Badi L, Barberis A (Aug 2001). "Proteins that genetically interact with the
Saccharomyces cerevisiae transcription factor Gal11p emphasize its role in the initiation-elongation transition".
2724:"TFIIB and subunits of the SAGA complex are involved in transcriptional activation of phospholipid biosynthetic genes by the regulatory protein Ino2 in the yeast Saccharomyces cerevisiae"
1705:
BrĂĽschweiler S, Schanda P, Kloiber K, Brutscher B, Kontaxis G, Konrat R, Tollinger M (Mar 2009). "Direct observation of the dynamic process underlying allosteric signal transmission".
65:). TADs are named after their amino acid composition. These amino acids are either essential for the activity or simply the most abundant in the TAD. Transactivation by the
137:
Nine-amino-acid transactivation domain (9aaTAD) defines a domain common to a large superfamily of eukaryotic transcription factors represented by Gal4, Oaf1, Leu3, Rtg3,
1136:
Mermod N, O'Neill EA, Kelly TJ, Tjian R (August 1989). "The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain".
791:
Hope IA, Mahadevan S, Struhl K (Jun 1988). "Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein".
1279:
Piskacek S, Gregor M, Nemethova M, Grabner M, Kovarik P, Piskacek M (Jun 2007). "Nine-amino-acid transactivation domain: establishment and prediction utilities".
1666:"Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators"
2763:
Mizuno T, Harashima S (Apr 2003). "Gal11 is a general activator of basal transcription, whose activity is regulated by the general repressor Sin4 in yeast".
2952:"TFIID and Spt-Ada-Gcn5-acetyltransferase functions probed by genome-wide synthetic genetic array analysis using a Saccharomyces cerevisiae taf9-ts allele"
1740:
Liu GH, Qu J, Shen X (May 2008). "NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK".
1093:
Courey AJ, Holtzman DA, Jackson SP, Tjian R (December 1989). "Synergistic activation by the glutamine-rich domains of human transcription factor Sp1".
2651:
Lim MK, Tang V, Le Saux A, SchĂĽller J, Bongards C, Lehming N (Nov 2007). "Gal11p dosage-compensates transcriptional activator deletions via Taf14p".
2911:"Use of a genetically introduced cross-linker to identify interaction sites of acidic activators within native transcription factor IID and SAGA"
1435:
Uesugi M, Nyanguile O, Lu H, Levine AJ, Verdine GL (Aug 1997). "Induced alpha helix in the VP16 activation domain upon binding to a human TAF".
2189:"A genome-wide analysis of transcriptional effect of Gal11 in Saccharomyces cerevisiae: an application of "mini-array hybridization technique""
1240:
1617:"Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions"
170:
158:
1983:"Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2"
1826:"Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP)"
2316:"GAL11 protein, an auxiliary transcription activator for genes encoding galactose-metabolizing enzymes in Saccharomyces cerevisiae"
890:"The transcriptional activator GCN4 contains multiple activation domains that are critically dependent on hydrophobic amino acids"
3065:
996:
Mitchell PJ, Tjian R (July 1989). "Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins".
84:
acidic domains (called also “acid blobs” or “negative noodles", rich in D and E amino acids, present in Gal4, Gcn4 and VP16).
2030:
Feng H, Jenkins LM, Durell SR, Hayashi R, Mazur SJ, Cherry S, Tropea JE, Miller M, Wlodawer A, Appella E, Bai Y (Feb 2009).
939:"Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator"
1039:
Sadowski I, Ma J, Triezenberg S, Ptashne M (October 1988). "GAL4-VP16 is an unusually potent transcriptional activator".
2860:"Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p"
842:
Hope IA, Struhl K (Sep 1986). "Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast".
202:
650:
Sadowski I, Ma J, Triezenberg S, Ptashne M (Oct 1988). "GAL4-VP16 is an unusually potent transcriptional activator".
54:
2365:"The Saccharomyces cerevisiae SPT13/GAL11 gene has both positive and negative regulatory roles in transcription"
3070:
520:
88:
1775:
Bayly R, Murase T, Hyndman BD, Savage R, Nurmohamed S, Munro K, Casselman R, Smith SP, LeBrun DP (Sep 2006).
1577:
1181:"Drosophila tissue-specific transcription factor NTF-1 contains a novel isoleucine-rich activation motif"
703:"Mutational analysis of a transcriptional activation region of the VP16 protein of herpes simplex virus"
570:"Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation"
205:. p53 9aaTADs interact with TAF9, GCN5 and with multiple domains of CBP/p300 (KIX, TAZ1,TAZ2 and IBiD).
1924:"Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53"
2816:
2474:
2092:
1935:
1389:
1330:
1048:
1005:
950:
800:
659:
549:
99:
46:
43:
1582:
544:
2140:"Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage"
2840:
2788:
2520:
Swanson MJ, Qiu H, Sumibcay L, Krueger A, Kim SJ, Natarajan K, Yoon S, Hinnebusch AG (Apr 2003).
2296:
2253:
2081:"Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2"
1646:
1161:
1118:
1072:
867:
824:
683:
208:
The KIX domain of general coactivators Med15(Gal11) interacts with 9aaTAD transcription factors
3030:
2981:
2932:
2891:
2832:
2780:
2745:
2704:
2668:
2633:
2592:
2551:
2502:
2443:
2394:
2345:
2288:
2245:
2210:
2169:
2120:
2061:
2012:
1963:
1904:
1855:
1806:
1757:
1722:
1687:
1638:
1597:
1542:
1493:
1452:
1417:
1358:
1296:
1256:
1236:
1202:
1153:
1110:
1064:
1021:
978:
919:
859:
816:
773:
732:
675:
632:
591:
3020:
3012:
3001:"Interaction between intrinsically disordered regions in transcription factors Sp1 and TAF4"
2971:
2963:
2922:
2881:
2871:
2824:
2772:
2735:
2696:
2660:
2623:
2582:
2541:
2533:
2492:
2482:
2433:
2425:
2384:
2376:
2335:
2327:
2280:
2237:
2200:
2159:
2151:
2110:
2100:
2051:
2043:
2002:
1994:
1953:
1943:
1894:
1886:
1845:
1837:
1796:
1788:
1749:
1714:
1677:
1628:
1587:
1532:
1524:
1483:
1444:
1407:
1397:
1348:
1338:
1288:
1246:
1228:
1192:
1145:
1102:
1056:
1013:
968:
958:
909:
901:
851:
808:
763:
722:
714:
667:
622:
581:
516:
1615:
Radhakrishnan I, PĂ©rez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE (Dec 1997).
110:
237:
233:
229:
217:
213:
66:
2820:
2478:
2096:
1939:
1393:
1334:
1052:
1009:
954:
804:
663:
69:
transcription factor is mediated by acidic amino acids, whereas hydrophobic residues in
3025:
3000:
2976:
2951:
2886:
2859:
2164:
2139:
2115:
2080:
2056:
2031:
2007:
1982:
1958:
1923:
1850:
1825:
1801:
1776:
1537:
1513:"Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP"
1512:
1353:
1318:
1251:
701:
Sullivan SM, Horn PJ, Olson VA, Koop AH, Niu W, Ebright RH, Triezenberg SJ (Oct 1998).
17:
2587:
2570:
2546:
2521:
2497:
2462:
2389:
2364:
2340:
2315:
1899:
1874:
1633:
1616:
1378:"The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2"
914:
889:
727:
702:
3059:
2844:
2740:
2723:
2700:
2571:"Independent recruitment in vivo by Gal4 of two complexes required for transcription"
2522:"A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo"
2438:
2429:
2413:
2284:
1412:
1377:
1149:
1106:
973:
938:
855:
768:
751:
627:
610:
527:). Although such is not the case for every Q-rich TAD, Sp1 is shown to interact with
524:
2537:
2463:"A target essential for the activity of a nonacidic yeast transcriptional activator"
2257:
1650:
1165:
871:
125:
2999:
Hibino E, Inoue R, Sugiyama M, Kuwahara J, Matsuzaki K, Hoshino M (November 2016).
2300:
2032:"Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation"
1122:
1076:
828:
687:
87:
glutamine-rich domains (contains multiple repetitions like "QQQXXXQQQ", present in
2792:
1448:
888:
Drysdale CM, Dueñas E, Jackson BM, Reusser U, Braus GH, Hinnebusch AG (Mar 1995).
2628:
2612:"Function of a eukaryotic transcription activator during the transcription cycle"
2611:
1753:
1343:
1232:
2967:
2079:
Ferreon JC, Lee CW, Arai M, Martinez-Yamout MA, Dyson HJ, Wright PE (Apr 2009).
1292:
1223:
Frietze S, Farnham PJ (14 April 2011). "Transcription Factor
Effector Domains".
2467:
Proceedings of the
National Academy of Sciences of the United States of America
2085:
Proceedings of the
National Academy of Sciences of the United States of America
1928:
Proceedings of the
National Academy of Sciences of the United States of America
1382:
Proceedings of the
National Academy of Sciences of the United States of America
943:
Proceedings of the
National Academy of Sciences of the United States of America
2776:
2664:
2047:
1777:"Critical role for a single leucine residue in leukemia induction by E2A-PBX1"
1561:
174:
130:
1488:
1471:
1402:
718:
2205:
2188:
2105:
1948:
1841:
1017:
3034:
2985:
2936:
2927:
2910:
2895:
2876:
2836:
2784:
2749:
2708:
2672:
2637:
2596:
2555:
2506:
2487:
2447:
2249:
2214:
2173:
2124:
2065:
2016:
1967:
1890:
1810:
1761:
1726:
1691:
1682:
1665:
1601:
1592:
1565:
1546:
1497:
1421:
1362:
1300:
1260:
595:
2909:
Klein J, Nolden M, Sanders SL, Kirchner J, Weil PA, Melcher K (Feb 2003).
2398:
2380:
2349:
2331:
2292:
2241:
1908:
1859:
1642:
1456:
1206:
1197:
1180:
1157:
1114:
1068:
1025:
982:
963:
923:
905:
863:
820:
777:
736:
679:
636:
2155:
1792:
586:
569:
249:
194:
154:
2828:
1998:
2858:
Thakur JK, Arthanari H, Yang F, Chau KH, Wagner G, Näär AM (Feb 2009).
2414:"In vivo requirement of activator-specific binding targets of mediator"
94:
proline-rich domains (contains repetitions like "PPPXXXPPP" present in
50:
1718:
1528:
3016:
1060:
812:
671:
512:
1511:
Lee CW, Arai M, Martinez-Yamout MA, Dyson HJ, Wright PE (Mar 2009).
3050:
2722:
Dietz M, Heyken WT, Hoppen J, Geburtig S, SchĂĽller HJ (May 2003).
532:
245:
190:
186:
124:
103:
95:
1317:
Piskacek M, Havelka M, Rezacova M, Knight A (12 September 2016).
1875:"Interaction and functional collaboration of p300 and C/EBPbeta"
1472:"Divergent hTAFII31-binding motifs hidden in activation domains"
528:
253:
241:
225:
221:
209:
198:
182:
178:
150:
142:
138:
74:
70:
2412:
Park JM, Kim HS, Han SJ, Hwang MS, Lee YC, Kim YJ (Dec 2000).
166:
146:
1742:
Biochimica et
Biophysica Acta (BBA) - Molecular Cell Research
1664:
Zor T, Mayr BM, Dyson HJ, Montminy MR, Wright PE (Nov 2002).
1227:. Subcellular Biochemistry. Vol. 52. pp. 261–277.
568:
Wärnmark A, Treuter E, Wright AP, Gustafsson JA (Oct 2003).
752:"Mutants of GAL4 protein altered in an activation function"
109:
isoleucine-rich domains (repetitions "IIXXII", present in
2461:
Lu Z, Ansari AZ, Lu X, Ogirala A, Ptashne M (Jun 2002).
77:
are referred to as acidic or hydrophobic, respectively.
1922:
Teufel DP, Freund SM, Bycroft M, Fersht AR (Apr 2007).
1319:"The 9aaTAD Transactivation Domains: From Gal4 to p53"
1088:
1086:
57:. These binding sites are frequently referred to as
2187:
Fukasawa T, Fukuma M, Yano K, Sakurai H (Feb 2001).
80:
In general we can distinguish four classes of TADs:
73:play a similar role. Hence, the TADs in Gal4 and
611:"A new class of yeast transcriptional activators"
2314:Suzuki Y, Nogi Y, Abe A, Fukasawa T (Nov 1988).
197:interact directly with the general coactivators
2950:Milgrom E, West RW, Gao C, Shen WC (Nov 2005).
1312:
1310:
1274:
1272:
1270:
1218:
1216:
937:Regier JL, Shen F, Triezenberg SJ (Feb 1993).
2610:Fishburn J, Mohibullah N, Hahn S (Apr 2005).
883:
881:
8:
1981:Teufel DP, Bycroft M, Fersht AR (May 2009).
1873:Mink S, Haenig B, Klempnauer KH (Nov 1997).
3024:
2975:
2926:
2885:
2875:
2739:
2627:
2586:
2545:
2496:
2486:
2437:
2388:
2339:
2204:
2163:
2114:
2104:
2055:
2006:
1957:
1947:
1898:
1849:
1800:
1681:
1632:
1591:
1581:
1536:
1487:
1411:
1401:
1352:
1342:
1250:
1196:
972:
962:
913:
767:
726:
626:
585:
1707:Journal of the American Chemical Society
258:
560:
49:which contains binding sites for other
1824:GarcĂa-RodrĂguez C, Rao A (Jun 1998).
1470:Choi Y, Asada S, Uesugi M (May 2000).
511:Glutamine (Q)-rich TADs are found in
260:Example 9aaTADs and KIX interactions
7:
1830:The Journal of Experimental Medicine
27:Transcription factor scaffold domain
2915:The Journal of Biological Chemistry
2864:The Journal of Biological Chemistry
1670:The Journal of Biological Chemistry
1570:The Journal of Biological Chemistry
1560:Goto NK, Zor T, Martinez-Yamout M,
1476:The Journal of Biological Chemistry
1225:A Handbook of Transcription Factors
2363:Fassler JS, Winston F (Dec 1989).
25:
2569:Bryant GO, Ptashne M (May 2003).
2138:Gamper AM, Roeder RG (Apr 2008).
1376:Uesugi M, Verdine GL (Dec 1999).
1179:Attardi LD, Tjian R (July 1993).
2741:10.1046/j.1365-2958.2003.03501.x
2701:10.1111/j.1365-2958.2006.05363.x
2430:10.1128/mcb.20.23.8709-8719.2000
2765:Molecular Genetics and Genomics
2538:10.1128/MCB.23.8.2800-2820.2003
2230:Molecular Genetics and Genomics
2526:Molecular and Cellular Biology
2418:Molecular and Cellular Biology
2369:Molecular and Cellular Biology
2320:Molecular and Cellular Biology
2144:Molecular and Cellular Biology
1879:Molecular and Cellular Biology
1781:Molecular and Cellular Biology
894:Molecular and Cellular Biology
750:Gill G, Ptashne M (Oct 1987).
271:Peptide-KIX interaction (NMR)
1:
2588:10.1016/S1097-2765(03)00144-8
1634:10.1016/S0092-8674(00)80463-8
1449:10.1126/science.277.5330.1310
165:9aaTAD transcription factors
2653:Journal of Molecular Biology
2629:10.1016/j.molcel.2005.03.029
2285:10.1016/0092-8674(94)90221-6
1754:10.1016/j.bbamcr.2008.01.002
1344:10.1371/journal.pone.0162842
1233:10.1007/978-90-481-9069-0_12
1150:10.1016/0092-8674(89)90108-6
1107:10.1016/0092-8674(89)90606-5
856:10.1016/0092-8674(86)90070-X
769:10.1016/0092-8674(87)90016-X
628:10.1016/0092-8674(87)90015-8
609:Ma J, Ptashne M (Oct 1987).
2968:10.1534/genetics.105.046557
1293:10.1016/j.ygeno.2007.02.003
531:(TAFII 130), a part of the
3087:
409:CREB-mutant binding to KIX
55:transcription coregulators
2777:10.1007/s00438-003-0810-x
2665:10.1016/j.jmb.2007.09.013
2048:10.1016/j.str.2008.12.009
1564:, Wright PE (Nov 2002).
1489:10.1074/jbc.275.21.15912
1403:10.1073/pnas.96.26.14801
424:TAD homology to CREB/KIX
2106:10.1073/pnas.0811023106
1949:10.1073/pnas.0702010104
1842:10.1084/jem.187.12.2031
1185:Genes & Development
1018:10.1126/science.2667136
574:Molecular Endocrinology
36:trans-activating domain
18:Trans-activating domain
3051:9aaTAD prediction tool
2928:10.1074/jbc.M212514200
2877:10.1074/jbc.M808263200
2728:Molecular Microbiology
2689:Molecular Microbiology
2488:10.1073/pnas.092263499
1891:10.1128/mcb.17.11.6609
1683:10.1074/jbc.M207361200
1593:10.1074/jbc.M207660200
719:10.1093/nar/26.19.4487
707:Nucleic Acids Research
134:
32:transactivation domain
3066:Transcription factors
2381:10.1128/mcb.9.12.5602
2332:10.1128/mcb.8.11.4991
2242:10.1007/s004380100505
2206:10.1093/dnares/8.1.23
1198:10.1101/gad.7.7b.1341
964:10.1073/pnas.90.3.883
906:10.1128/mcb.15.3.1220
439:Pdr1 and Oaf1 homolog
128:
2156:10.1128/MCB.01461-07
1793:10.1128/MCB.02025-05
587:10.1210/me.2002-0384
550:Transcription factor
59:activation functions
44:transcription factor
2829:10.1038/nature06836
2821:2008Natur.452..604T
2479:2002PNAS...99.8591L
2097:2009PNAS..106.6591F
1999:10.1038/onc.2009.71
1940:2007PNAS..104.7009T
1394:1999PNAS...9614801U
1335:2016PLoSO..1162842P
1053:1988Natur.335..563S
1010:1989Sci...245..371M
955:1993PNAS...90..883R
805:1988Natur.333..635H
664:1988Natur.335..563S
545:DNA-binding protein
261:
259:
135:
3011:(11): 2006–2017.
1719:10.1021/ja809947w
1529:10.1021/bi802055v
1242:978-90-481-9068-3
504:
503:
145:in yeast, and by
16:(Redirected from
3078:
3039:
3038:
3028:
3017:10.1002/pro.3013
2996:
2990:
2989:
2979:
2947:
2941:
2940:
2930:
2906:
2900:
2899:
2889:
2879:
2855:
2849:
2848:
2803:
2797:
2796:
2760:
2754:
2753:
2743:
2719:
2713:
2712:
2683:
2677:
2676:
2648:
2642:
2641:
2631:
2607:
2601:
2600:
2590:
2566:
2560:
2559:
2549:
2517:
2511:
2510:
2500:
2490:
2458:
2452:
2451:
2441:
2409:
2403:
2402:
2392:
2360:
2354:
2353:
2343:
2311:
2305:
2304:
2268:
2262:
2261:
2225:
2219:
2218:
2208:
2184:
2178:
2177:
2167:
2135:
2129:
2128:
2118:
2108:
2076:
2070:
2069:
2059:
2027:
2021:
2020:
2010:
1978:
1972:
1971:
1961:
1951:
1919:
1913:
1912:
1902:
1870:
1864:
1863:
1853:
1821:
1815:
1814:
1804:
1772:
1766:
1765:
1737:
1731:
1730:
1702:
1696:
1695:
1685:
1661:
1655:
1654:
1636:
1612:
1606:
1605:
1595:
1585:
1576:(45): 43168–74.
1557:
1551:
1550:
1540:
1508:
1502:
1501:
1491:
1467:
1461:
1460:
1443:(5330): 1310–3.
1432:
1426:
1425:
1415:
1405:
1373:
1367:
1366:
1356:
1346:
1314:
1305:
1304:
1276:
1265:
1264:
1254:
1220:
1211:
1210:
1200:
1176:
1170:
1169:
1133:
1127:
1126:
1090:
1081:
1080:
1061:10.1038/335563a0
1036:
1030:
1029:
993:
987:
986:
976:
966:
934:
928:
927:
917:
885:
876:
875:
839:
833:
832:
813:10.1038/333635a0
799:(6174): 635–40.
788:
782:
781:
771:
747:
741:
740:
730:
698:
692:
691:
672:10.1038/335563a0
647:
641:
640:
630:
606:
600:
599:
589:
565:
495:
485:
480:
465:
455:
450:
435:
420:
405:
395:
372:
357:
347:
338:
328:
319:
309:
300:
290:
281:
262:
21:
3086:
3085:
3081:
3080:
3079:
3077:
3076:
3075:
3071:Protein domains
3056:
3055:
3047:
3042:
3005:Protein Science
2998:
2997:
2993:
2949:
2948:
2944:
2908:
2907:
2903:
2857:
2856:
2852:
2815:(7187): 604–9.
2805:
2804:
2800:
2762:
2761:
2757:
2721:
2720:
2716:
2685:
2684:
2680:
2650:
2649:
2645:
2609:
2608:
2604:
2568:
2567:
2563:
2519:
2518:
2514:
2460:
2459:
2455:
2424:(23): 8709–19.
2411:
2410:
2406:
2362:
2361:
2357:
2313:
2312:
2308:
2270:
2269:
2265:
2227:
2226:
2222:
2186:
2185:
2181:
2137:
2136:
2132:
2078:
2077:
2073:
2029:
2028:
2024:
1980:
1979:
1975:
1934:(17): 7009–14.
1921:
1920:
1916:
1885:(11): 6609–17.
1872:
1871:
1867:
1823:
1822:
1818:
1787:(17): 6442–52.
1774:
1773:
1769:
1739:
1738:
1734:
1704:
1703:
1699:
1676:(44): 42241–8.
1663:
1662:
1658:
1614:
1613:
1609:
1583:10.1.1.615.9401
1559:
1558:
1554:
1523:(10): 2115–24.
1510:
1509:
1505:
1482:(21): 15912–6.
1469:
1468:
1464:
1434:
1433:
1429:
1388:(26): 14801–6.
1375:
1374:
1370:
1329:(9): e0162842.
1316:
1315:
1308:
1278:
1277:
1268:
1243:
1222:
1221:
1214:
1191:(7B): 1341–53.
1178:
1177:
1173:
1135:
1134:
1130:
1092:
1091:
1084:
1047:(6190): 563–4.
1038:
1037:
1033:
1004:(4916): 371–8.
995:
994:
990:
936:
935:
931:
887:
886:
879:
841:
840:
836:
790:
789:
785:
749:
748:
744:
713:(19): 4487–96.
700:
699:
695:
658:(6190): 563–4.
649:
648:
644:
608:
607:
603:
567:
566:
562:
558:
541:
509:
493:
483:
478:
463:
453:
448:
433:
418:
403:
375:
370:
355:
341:
336:
322:
317:
303:
298:
284:
279:
123:
47:scaffold domain
28:
23:
22:
15:
12:
11:
5:
3084:
3082:
3074:
3073:
3068:
3058:
3057:
3054:
3053:
3046:
3045:External links
3043:
3041:
3040:
2991:
2942:
2921:(9): 6779–86.
2901:
2850:
2798:
2755:
2734:(4): 1119–30.
2714:
2678:
2643:
2616:Molecular Cell
2602:
2575:Molecular Cell
2561:
2532:(8): 2800–20.
2512:
2473:(13): 8591–6.
2453:
2404:
2375:(12): 5602–9.
2355:
2326:(11): 4991–9.
2306:
2279:(4): 599–608.
2263:
2236:(6): 1076–86.
2220:
2179:
2150:(8): 2517–27.
2130:
2091:(16): 6591–6.
2071:
2022:
1993:(20): 2112–8.
1973:
1914:
1865:
1836:(12): 2031–6.
1816:
1767:
1732:
1697:
1656:
1607:
1552:
1503:
1462:
1427:
1368:
1306:
1266:
1241:
1212:
1171:
1128:
1082:
1031:
988:
929:
900:(3): 1220–33.
877:
834:
783:
742:
693:
642:
601:
580:(10): 1901–9.
559:
557:
554:
553:
552:
547:
540:
537:
508:
507:Glutamine-rich
505:
502:
501:
496:
491:
487:
486:
481:
476:
472:
471:
466:
461:
457:
456:
451:
446:
442:
441:
436:
431:
427:
426:
421:
416:
412:
411:
406:
401:
397:
396:
373:
368:
364:
363:
358:
353:
349:
348:
339:
334:
330:
329:
320:
315:
311:
310:
301:
296:
292:
291:
282:
277:
273:
272:
269:
266:
122:
119:
115:
114:
107:
92:
85:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3083:
3072:
3069:
3067:
3064:
3063:
3061:
3052:
3049:
3048:
3044:
3036:
3032:
3027:
3022:
3018:
3014:
3010:
3006:
3002:
2995:
2992:
2987:
2983:
2978:
2973:
2969:
2965:
2962:(3): 959–73.
2961:
2957:
2953:
2946:
2943:
2938:
2934:
2929:
2924:
2920:
2916:
2912:
2905:
2902:
2897:
2893:
2888:
2883:
2878:
2873:
2870:(7): 4422–8.
2869:
2865:
2861:
2854:
2851:
2846:
2842:
2838:
2834:
2830:
2826:
2822:
2818:
2814:
2810:
2802:
2799:
2794:
2790:
2786:
2782:
2778:
2774:
2770:
2766:
2759:
2756:
2751:
2747:
2742:
2737:
2733:
2729:
2725:
2718:
2715:
2710:
2706:
2702:
2698:
2695:(2): 438–52.
2694:
2690:
2682:
2679:
2674:
2670:
2666:
2662:
2658:
2654:
2647:
2644:
2639:
2635:
2630:
2625:
2622:(3): 369–78.
2621:
2617:
2613:
2606:
2603:
2598:
2594:
2589:
2584:
2581:(5): 1301–9.
2580:
2576:
2572:
2565:
2562:
2557:
2553:
2548:
2543:
2539:
2535:
2531:
2527:
2523:
2516:
2513:
2508:
2504:
2499:
2494:
2489:
2484:
2480:
2476:
2472:
2468:
2464:
2457:
2454:
2449:
2445:
2440:
2435:
2431:
2427:
2423:
2419:
2415:
2408:
2405:
2400:
2396:
2391:
2386:
2382:
2378:
2374:
2370:
2366:
2359:
2356:
2351:
2347:
2342:
2337:
2333:
2329:
2325:
2321:
2317:
2310:
2307:
2302:
2298:
2294:
2290:
2286:
2282:
2278:
2274:
2267:
2264:
2259:
2255:
2251:
2247:
2243:
2239:
2235:
2231:
2224:
2221:
2216:
2212:
2207:
2202:
2198:
2194:
2190:
2183:
2180:
2175:
2171:
2166:
2161:
2157:
2153:
2149:
2145:
2141:
2134:
2131:
2126:
2122:
2117:
2112:
2107:
2102:
2098:
2094:
2090:
2086:
2082:
2075:
2072:
2067:
2063:
2058:
2053:
2049:
2045:
2042:(2): 202–10.
2041:
2037:
2033:
2026:
2023:
2018:
2014:
2009:
2004:
2000:
1996:
1992:
1988:
1984:
1977:
1974:
1969:
1965:
1960:
1955:
1950:
1945:
1941:
1937:
1933:
1929:
1925:
1918:
1915:
1910:
1906:
1901:
1896:
1892:
1888:
1884:
1880:
1876:
1869:
1866:
1861:
1857:
1852:
1847:
1843:
1839:
1835:
1831:
1827:
1820:
1817:
1812:
1808:
1803:
1798:
1794:
1790:
1786:
1782:
1778:
1771:
1768:
1763:
1759:
1755:
1751:
1748:(5): 713–27.
1747:
1743:
1736:
1733:
1728:
1724:
1720:
1716:
1713:(8): 3063–8.
1712:
1708:
1701:
1698:
1693:
1689:
1684:
1679:
1675:
1671:
1667:
1660:
1657:
1652:
1648:
1644:
1640:
1635:
1630:
1627:(6): 741–52.
1626:
1622:
1618:
1611:
1608:
1603:
1599:
1594:
1589:
1584:
1579:
1575:
1571:
1567:
1563:
1556:
1553:
1548:
1544:
1539:
1534:
1530:
1526:
1522:
1518:
1514:
1507:
1504:
1499:
1495:
1490:
1485:
1481:
1477:
1473:
1466:
1463:
1458:
1454:
1450:
1446:
1442:
1438:
1431:
1428:
1423:
1419:
1414:
1409:
1404:
1399:
1395:
1391:
1387:
1383:
1379:
1372:
1369:
1364:
1360:
1355:
1350:
1345:
1340:
1336:
1332:
1328:
1324:
1320:
1313:
1311:
1307:
1302:
1298:
1294:
1290:
1287:(6): 756–68.
1286:
1282:
1275:
1273:
1271:
1267:
1262:
1258:
1253:
1248:
1244:
1238:
1234:
1230:
1226:
1219:
1217:
1213:
1208:
1204:
1199:
1194:
1190:
1186:
1182:
1175:
1172:
1167:
1163:
1159:
1155:
1151:
1147:
1144:(4): 741–53.
1143:
1139:
1132:
1129:
1124:
1120:
1116:
1112:
1108:
1104:
1101:(5): 827–36.
1100:
1096:
1089:
1087:
1083:
1078:
1074:
1070:
1066:
1062:
1058:
1054:
1050:
1046:
1042:
1035:
1032:
1027:
1023:
1019:
1015:
1011:
1007:
1003:
999:
992:
989:
984:
980:
975:
970:
965:
960:
956:
952:
948:
944:
940:
933:
930:
925:
921:
916:
911:
907:
903:
899:
895:
891:
884:
882:
878:
873:
869:
865:
861:
857:
853:
850:(6): 885–94.
849:
845:
838:
835:
830:
826:
822:
818:
814:
810:
806:
802:
798:
794:
787:
784:
779:
775:
770:
765:
761:
757:
753:
746:
743:
738:
734:
729:
724:
720:
716:
712:
708:
704:
697:
694:
689:
685:
681:
677:
673:
669:
665:
661:
657:
653:
646:
643:
638:
634:
629:
624:
620:
616:
612:
605:
602:
597:
593:
588:
583:
579:
575:
571:
564:
561:
555:
551:
548:
546:
543:
542:
538:
536:
534:
530:
526:
525:Sp/KLF family
522:
518:
514:
506:
500:
497:
492:
489:
488:
482:
477:
474:
473:
470:
467:
462:
459:
458:
452:
447:
444:
443:
440:
437:
432:
429:
428:
425:
422:
417:
414:
413:
410:
407:
402:
399:
398:
394:
390:
386:
382:
378:
374:
369:
366:
365:
362:
359:
354:
351:
350:
345:
340:
335:
332:
331:
326:
321:
316:
313:
312:
307:
302:
297:
294:
293:
288:
283:
278:
275:
274:
270:
267:
264:
263:
257:
255:
251:
247:
243:
239:
235:
231:
227:
223:
219:
215:
211:
206:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
163:
160:
156:
152:
148:
144:
140:
132:
127:
121:Acidic/9aaTAD
120:
118:
112:
108:
105:
101:
97:
93:
90:
86:
83:
82:
81:
78:
76:
72:
68:
64:
60:
56:
52:
48:
45:
41:
37:
33:
19:
3008:
3004:
2994:
2959:
2955:
2945:
2918:
2914:
2904:
2867:
2863:
2853:
2812:
2808:
2801:
2771:(1): 68–77.
2768:
2764:
2758:
2731:
2727:
2717:
2692:
2688:
2681:
2656:
2652:
2646:
2619:
2615:
2605:
2578:
2574:
2564:
2529:
2525:
2515:
2470:
2466:
2456:
2421:
2417:
2407:
2372:
2368:
2358:
2323:
2319:
2309:
2276:
2272:
2266:
2233:
2229:
2223:
2199:(1): 23–31.
2196:
2193:DNA Research
2192:
2182:
2147:
2143:
2133:
2088:
2084:
2074:
2039:
2035:
2025:
1990:
1986:
1976:
1931:
1927:
1917:
1882:
1878:
1868:
1833:
1829:
1819:
1784:
1780:
1770:
1745:
1741:
1735:
1710:
1706:
1700:
1673:
1669:
1659:
1624:
1620:
1610:
1573:
1569:
1555:
1520:
1517:Biochemistry
1516:
1506:
1479:
1475:
1465:
1440:
1436:
1430:
1385:
1381:
1371:
1326:
1322:
1284:
1280:
1224:
1188:
1184:
1174:
1141:
1137:
1131:
1098:
1094:
1044:
1040:
1034:
1001:
997:
991:
949:(3): 883–7.
946:
942:
932:
897:
893:
847:
843:
837:
796:
792:
786:
762:(1): 121–6.
759:
755:
745:
710:
706:
696:
655:
651:
645:
621:(1): 113–9.
618:
614:
604:
577:
573:
563:
519:(Oct2), and
510:
499:Pdr1 homolog
498:
484:EDLYSILWSDWY
469:Oafl homolog
468:
438:
423:
408:
392:
388:
384:
380:
376:
360:
343:
324:
305:
286:
207:
164:
136:
116:
79:
62:
58:
39:
35:
31:
29:
2659:(1): 9–23.
494:T DLYH TLWN
479:E DLYS ILWS
464:D FFDY DLLF
449:D LFDY DFLV
434:D DVYN YLFD
419:D DVVQ YLNS
404:E AILA ELKK
371:R KILN DLSS
361:E2A homolog
356:E TLDF SLVT
342:PVGTDKELSDL
337:D LLDF SMMF
318:S DIMD FVLK
299:D DIEQ WFTE
280:E TFSD LWKL
3060:Categories
556:References
535:assembly.
523:(see also
325:LPSDIMDFVL
131:KIX domain
2845:205212715
2036:Structure
1578:CiteSeerX
454:DLFDYDFLV
304:QAMDDLMLS
295:p53 TAD2
276:p53 TAD1
133:complexes
3035:27515574
2986:16118188
2956:Genetics
2937:12501245
2896:19056732
2837:18385733
2785:12715155
2750:12753200
2709:17020582
2673:17919657
2638:15866178
2597:12769853
2556:12665580
2507:12084920
2448:11073972
2258:19287634
2250:11523780
2215:11258797
2174:18250150
2125:19357310
2066:19217391
2017:19363523
1987:Oncogene
1968:17438265
1811:16914730
1762:18241676
1727:19203263
1692:12196545
1651:17268267
1602:12205094
1562:Dyson HJ
1547:19220000
1498:10821850
1422:10611293
1363:27618436
1323:PLOS ONE
1301:17467953
1281:Genomics
1261:21557087
1166:22817940
872:40730692
596:12893880
539:See also
515:(Oct1),
400:CREBaB6
346:MMFPLPVT
306:PDDIEQWF
250:CBP/p300
224:, VP16,
203:CBP/p300
141:, Gln3,
53:such as
51:proteins
3026:5079245
2977:1456853
2887:3837390
2817:Bibcode
2475:Bibcode
2399:2685570
2350:3062377
2301:5002125
2293:8187178
2165:2293101
2116:2672497
2093:Bibcode
2057:2705179
2008:2685776
1959:1855428
1936:Bibcode
1909:9343424
1860:9625762
1851:2212364
1802:1592826
1643:9413984
1538:2765525
1457:9271577
1437:Science
1390:Bibcode
1354:5019370
1331:Bibcode
1252:4151296
1207:8330738
1158:2504497
1123:2910480
1115:2512012
1077:4276393
1069:3047590
1049:Bibcode
1026:2667136
1006:Bibcode
998:Science
983:8381535
951:Bibcode
924:7862116
864:3530496
829:2635634
821:3287180
801:Bibcode
778:3115592
737:9742254
688:4276393
680:3047590
660:Bibcode
637:3115591
379:EILSRRP
308:TEDPGPD
268:9aaTAD
265:Source
129:9aaTAD-
42:) is a
3033:
3023:
2984:
2974:
2935:
2894:
2884:
2843:
2835:
2809:Nature
2793:882139
2791:
2783:
2748:
2707:
2671:
2636:
2595:
2554:
2547:152555
2544:
2505:
2498:124323
2495:
2446:
2436:
2397:
2390:363730
2387:
2348:
2341:365593
2338:
2299:
2291:
2256:
2248:
2213:
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