Knowledge (XXG)

Transitional epithelium

Source πŸ“

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The procedure entails removing the segment of cancerous ureter and reattaching the end. Patients with advanced bladder cancer or disease, also often look to bladder reconstruction as a treatment. Current methods of bladder reconstruction include the use of gastrointestinal tissue. However, while this method is effective in improving the function of the bladder, it can actually increases the risk of cancer, and can cause other complications, such as infections, urinary stones, and electrolyte imbalance. Therefore, other methods loom in the future. For example, current research paves the way for use of pluripotent stem cells to derive urothelium, as they are highly and indefinitely proliferative in vitro (i.e. outside of the body).
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is due to a highly keratinized cellular membrane synthesized in the Golgi apparatus. The membrane is made up of a hexagonal lattice put together in the Golgi apparatus and implanted into the surface of the cell by reverse pinocytosis, a type of exocytosis. The cells in the superficial layer of the transitional epithelium are highly differentiated, allowing for maintenance of this barrier membrane. The basal layer of the epithelium is much less differentiated; however, it does act as a replacement source for more superficial layer. While the Golgi complex is much less prominent in the cells of the basal layer, these cells are rich in cytoplasmic proteins that bundle together to form
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Transitional cell carcinoma patients have a variety of treatment options. These include nephroureterectomy, or the removal of kidney, ureter, and bladder cuff, and segmental resection of the ureter. This is an option only when the cancer is superficial and infects only the bottom third of the ureter.
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is a chronic disease of the bladder that causes feelings of pressure and pain in the bladder among other symptoms which can range from mild to severe. Urinary frequency and urgency are the most common symptoms associated with the disease. The exact causes of IC/BPS are unknown, but there is evidence
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The urothelium is the most impermeable membrane in the mammalian body. Because of its importance in acting as an osmotic barrier between the contents of the urinary tract and the surrounding organs and tissues, transitional epithelium is relatively impermeable to water and salts. This impermeability
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Transitional cell carcinoma can metastasize, or spread to other parts of the body via the surrounding tissues, the lymph system, and the bloodstream. It can spread to the tissues and fat surrounding the kidney, the fat surrounding the ureter, or, more progressively, lymph nodes and other organs,
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The epithelium contains many intimate and delicate connections to neural and connective tissue. These connections allow for communication to tell the cells to expand or contract. The superficial layer of transitional epithelium is connected to the basal layer via cellular projections, such as
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Poon, Song Ling; Huang, Mi Ni; Choo, Yang; McPherson, John R.; Yu, Willie; Heng, Hong Lee; Gan, Anna; Myint, Swe Swe; Siew, Ee Yan; Ler, Lian Dee; Ng, Lay Guat; Weng, Wen-Hui; Chuang, Cheng-Keng; Yuen, John SP; Pang, See-Tong; Tan, Patrick; Teh, Bin Tean; Rozen, Steven G. (Dec 2015).
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The transitional epithelium cells stretch readily in order to accommodate fluctuation of volume of the liquid in an organ (the distal part of the urethra becomes non-keratinized stratified squamous epithelium in females; the part that lines the bottom of the tissue is called the
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intermediate filaments protruding from the cellular membrane. These structural elements cause the epithelium to allow distension; however, these also cause the tissue to be relatively fragile and, therefore, difficult to study. All cells touch the basement membrane.
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of an association between increased permeability of the urothelium and IC. Since the purpose of the urothelium is to act as a highly resistant barrier, the loss of this function has serious clinical implications. Many patients with IC have exhibited a loss of
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Transitional epithelium is made up of three types of cell layers: basal, intermediate, and superficial. The basal layer fosters the epithelial stem cells in order to provide constant renewal of the epithelium. These cells' cytoplasm is rich in tonofilaments and
307:. Transitional epithelium is a type of tissue that changes shape in response to stretching (stretchable epithelium). The transitional epithelium usually appears cuboidal when relaxed and squamous when stretched. This tissue consists of multiple layers of 376:
and an array of membrane-bound vesicles. These function in the packaging and transport of proteins, such as keratin, to the superficial cell layer. The cells of the superficial cell layer that lines the lumen are known as
372:. The intermediate cell layer is highly proliferative and, therefore, provides for rapid cell regeneration in response to injury or infection of the organ or tube in which it resides. These cells contain a prominent 490:
including bone. Common risk factors of transitional cell carcinoma include long-term misuse of pain medication, smoking, and exposure to chemicals used in the making of leather, plastic, textiles, and rubber.
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Transitional epithelium animation, highlighting the epithelial layer, then underlying connective tissue. Contrast the messy appearance of the epithelial surface to other epithelial tissues.
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Firth, J. A., & Hicks, R. M. (1973). Interspecies variation in the fine structure and enzyme cytochemistry of mammalian transitional epithelium. Journal of Anatomy, 116(Pt 1), 31–43.
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Osborn, S. L., & Kurzrock, E. A. (2015). Production of Urothelium from Pluripotent Stem Cells for Regenerative Applications. Current Urology Reports, 16(1), 1+. Retrieved from
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mutations and is a cause of liver, urothelial and bladder cancers. Occupational exposure to certain chemicals is also a risk factor for bladder cancer. This can include
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Urothelium is susceptible to carcinoma. Because the bladder is in contact with urine for extended periods, chemicals that become concentrated in the urine can cause
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Monis, B., & Zambrano, D. (1968). Ultrastructure of transitional epithelium of man. Zeitschrift fΓΌr Zellforschung und Microscopical Anatomie, 87(1), 101-117.
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Hurst, Robert E.; Greenwood-Van Meerveld, Beverley; Wisniewski, Amy B.; VanGordon, Samuel; Lin, HsuehKung; Kropp, Bradley P.; Towner, Rheal A. (October 2015).
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http://go.galegroup.com/ps/i.do?id=GALE%7CA390522720&v=2.1&u=clemsonu_main&it=r&p=AONE&sw=w&asid=bf6961c15c9b9523113dee93fd8df89c
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cells which can contract and expand in order to adapt to the degree of distension needed. Transitional epithelium lines the organs of the
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Hicks, R. (1966). THE FUNCTION OF THE GOLGI COMPLEX IN TRANSITIONAL EPITHELIUM: Synthesis of the Thick Cell Membrane.
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https://my.clevelandclinic.org/health/diseases_conditions/hic_Transitional_Cell_Cancer_of_Renal_Pelvis_and_Ureter
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www.urothelium.com is an online resource for information about Human Urothelium and the "Biomimetic Urothelium"
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The appearance of transitional epithelium differs according to its cell layer. Cells of the basal layer are
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leads to the concentration of carcinogens in the urine and is a leading cause of bladder cancer.
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http://www.cancer.org/cancer/bladdercancer/detailedguide/bladder-cancer-what-is-bladder-cancer
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American Cancer Society. (2014). Bladder cancer. Retrieved November 25, 2014, from
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Hicks, R. (1965). The Fine Structure Of The Transitional Epithelium Of Rat Ureter.
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Philosophical Transactions of the Royal Society of London. B, Biological Sciences
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Transitional Cell Cancer. (2012, April 13). Retrieved December 14, 2014, from
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Meldolesi, J.; Markham, Roy; Horne, R. W.; Hicks, R. Marian (1974-07-04).
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at the University of Oklahoma Health Sciences Center - "urinary bladder"
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at the University of Oklahoma Health Sciences Center - "ureter"
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Urothelial carcinoma with syncitiotrophoblastic giant cells
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Urothelial carcinoma similar to giant cell tumor of bone
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Urothelial carcinoma, clear cell (glycogen-rich) variant
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Urothelial carcinoma with villoglandular differentiation
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Papillary urothelial neoplasm of low malignant potential
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is a type of cancer that occurs in epithelial cells.
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Urothelial carcinoma, lymphoepithelioma-like variant
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List of distinct cell types in the adult human body
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Retrieved November 25, 2014, from 410:to attach the cells at the basement membrane. 1261: 963:: CS1 maint: DOI inactive as of March 2024 ( 273: 8: 1023: 1021: 816: 814: 812: 629:Urothelial carcinoma, micropapillary variant 783: 781: 447:, a compound found in plants of the family 1449: 1442: 1394: 1360: 1314: 1268: 1254: 1246: 280: 266: 105: 39: 27: 1202:at the U.S. National Library of Medicine 1097: 940: 930: 692:Schematic view of transitional epithelium 644:Urothelial carcinoma, lipoid cell variant 581:Urothelial atypia of unknown significance 554:High-grade papillary urothelial carcinoma 799: 797: 795: 793: 775:(9th ed., pp. 122-124). Boston: Pearson. 549:Low-grade papillary urothelial carcinoma 898: 896: 894: 736: 670: 245: 194: 171: 143: 120: 113: 956: 93: 18: 7: 1405:Pseudostratified columnar epithelium 771:Marieb, E., & Hoehn, K. (2013). 742: 740: 1173:- "Transitional Epithelium", Ureter 1082:10.3978/j.issn.2223-4683.2015.10.03 1070:Translational Andrology and Urology 320: 109:This article is part of a series on 254:Table of epithelia of human organs 14: 704:Vertical section of bladder wall. 709: 697: 685: 673: 529:Papillary urothelial hyperplasia 461:polycyclic aromatic hydrocarbons 406:. These tonofibrils converge at 90:Anatomical terms of microanatomy 747:Sapkota, Anupama (2020-09-28). 45:Transitional epithelium of the 1385:Stratified columnar epithelium 1378:Stratified cuboidal epithelium 1371:Stratified squamous epithelium 773:Human anatomy & physiology 1: 1124:Andersson, Karl-Erik (2011). 979:"Bladder cancer risk factors" 716:Transverse section of ureter. 604:Invasive urothelial carcinoma 576:Urothelial inverted papilloma 559:Invasive urothelial carcinoma 463:, and diesel engine exhaust. 389:and a fibrillar mucous coat. 880:The Journal of Cell Biology, 822:The Journal of Cell Biology, 591:Urothelial carcinoma in situ 524:Papillary urothelial lesions 364:; however, they contain few 476:Transitional cell carcinoma 366:rough endoplasmic reticulum 1630: 1351:Simple columnar epithelium 1344:Simple cuboidal epithelium 1325:Simple squamous epithelium 571:Reactive urothelial atypia 932:10.1186/s13073-015-0161-3 88: 38: 26: 1204:Medical Subject Headings 507:painful bladder syndrome 173:Cuboidal epithelial cell 145:Columnar epithelial cell 122:Squamous epithelial cell 1419:Transitional epithelium 1210:Histology at qmul.ac.uk 935:(inactive 2024-03-19). 566:Flat urothelial lesions 478:is the leading type of 301:Transitional epithelium 33:Transitional epithelium 22:Transitional epithelium 1410:Respiratory epithelium 1163:Histology image: 37_02 1157:Histology image: 36_02 858:10.1098/rstb.1974.0014 297: 1234:Histology at wisc.edu 1152:Histology at utmb.edu 1045:www.urologyhealth.org 503:Interstitial cystitis 498:Interstitial cystitis 431:Clinical significance 315:and is known here as 305:stratified epithelium 295: 195:Specialised epithelia 1222:Diagram at umich.edu 599:urothelial carcinoma 586:Urothelial dysplasia 534:Urothelial papilloma 680:Types of epithelium 1551:Myoepithelial cell 1239:2008-06-10 at the 1227:2006-09-10 at the 1215:2011-07-21 at the 1193:2011-02-01 at the 1012:2016-12-01 at the 983:Cancer Research UK 518:Urothelial lesions 343:(cube-shaped), or 298: 83:H2.00.02.0.02033 1601: 1600: 1597: 1596: 1539: 1538: 1434: 1433: 1393: 1392: 1359: 1358: 1177:Histology at KUMC 1137:978-3-642-16498-9 445:Aristolochic acid 441:cigarette smoking 421:basement membrane 290: 289: 104: 103: 99: 1621: 1614:Epithelial cells 1450: 1443: 1395: 1361: 1315: 1270: 1263: 1256: 1247: 1141: 1112: 1111: 1101: 1061: 1055: 1054: 1052: 1051: 1037: 1031: 1025: 1016: 1003: 994: 993: 991: 989: 975: 969: 968: 962: 954: 944: 934: 909: 903: 900: 889: 876: 870: 869: 837: 831: 818: 807: 801: 788: 785: 776: 769: 763: 762: 760: 759: 744: 713: 701: 689: 677: 449:Aristolochiaceae 439:. For example, 322: 282: 275: 268: 164:Pseudostratified 106: 96:edit on Wikidata 43: 31: 19: 16:A type of tissue 1629: 1628: 1624: 1623: 1622: 1620: 1619: 1618: 1604: 1603: 1602: 1593: 1556:Serous demilune 1535: 1514: 1493: 1430: 1389: 1355: 1306: 1280: 1274: 1241:Wayback Machine 1229:Wayback Machine 1217:Wayback Machine 1195:Wayback Machine 1181:urinary-renal16 1148: 1138: 1123: 1120: 1115: 1063: 1062: 1058: 1049: 1047: 1039: 1038: 1034: 1026: 1019: 1014:Wayback Machine 1004: 997: 987: 985: 977: 976: 972: 955: 919:Genome Medicine 911: 910: 906: 901: 892: 877: 873: 839: 838: 834: 819: 810: 802: 791: 786: 779: 770: 766: 757: 755: 746: 745: 738: 734: 724: 717: 714: 705: 702: 693: 690: 681: 678: 669: 520: 505:(IC) a type of 500: 469: 459:(aniline dye), 457:aromatic amines 433: 416: 399: 374:Golgi apparatus 357: 351:and irregular. 337: 286: 100: 50: 34: 17: 12: 11: 5: 1627: 1625: 1617: 1616: 1606: 1605: 1599: 1598: 1595: 1594: 1592: 1591: 1582: 1581: 1580: 1575: 1570: 1559: 1558: 1553: 1547: 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Index



bladder
System
Urinary system
TH
H2.00.02.0.02033
Anatomical terms of microanatomy
edit on Wikidata
Epithelia
Squamous epithelial cell
Simple
Stratified
Columnar epithelial cell
Simple
Stratified
Pseudostratified
Cuboidal epithelial cell
Simple
Stratified
Olfactory
Respiratory
Intestinal
Transitional
Vaginal
female
male
Table of epithelia of human organs
v
t

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