1086:
1304:
1321:
1564:
245:
1338:
222:
119:
144:
1287:
1500:, so that the domain structure of tropoelastin reflects the exon organization of the gene. The hydrophilic domains contain Lys-Ala (KA) and Lys-Pro (KP) motifs that are involved in crosslinking during the formation of mature elastin. In the KA domains, lysine residues occur as pairs or triplets separated by two or three alanine residues (e.g. AAAKAAKAA) whereas in KP domains the lysine residues are separated mainly by proline residues (e.g. KPLKP).
251:
150:
1352:
1387:. The total elastin ranges from 58 to 75% of the weight of the dry defatted artery in normal canine arteries. Comparison between fresh and digested tissues shows that, at 35% strain, a minimum of 48% of the arterial load is carried by elastin, and a minimum of 43% of the change in stiffness of arterial tissue is due to the change in elastin stiffness.
1447:
The feasibility of using recombinant human tropoelastin to enable elastin fiber production to improve skin flexibility in wounds and scarring has been studied. After subcutaneous injections of recombinant human tropoelastin into fresh wounds it was found there was no improvement in scarring or the
1156:
residues. Multiple transcript variants encoding different isoforms have been found for this gene. Elastin's soluble precursor is tropoelastin. The characterization of disorder is consistent with an entropy-driven mechanism of elastic recoil. It is concluded that conformational disorder is a
1123:
of the body to resume its shape after stretching or contracting. Elastin helps skin return to its original position whence poked or pinched. Elastin is also in important load-bearing tissue of vertebrates and used in places where storage of mechanical energy is required.
1473:), to make the final massive, insoluble, durable complex. The unlinked tropoelastin molecules are not normally available in the cell, since they become crosslinked into elastin fibres immediately after their synthesis by the cell and export into the
1610:
of the tropoelastin gene. There are at least 11 known human tropoelastin isoforms. these isoforms are under developmental regulation, however there are minimal differences among tissues at the same developmental stage.
2357:
Xie H, Lucchesi L, Zheng B, Ladich E, Pineda T, Merten R, et al. (1 September 2017). "Treatment of Burn and
Surgical Wounds With Recombinant Human Tropoelastin Produces New Elastin Fibers in Scars".
3015:
Bertram C, Hass R (October 2009). "Cellular senescence of human mammary epithelial cells (HMEC) is associated with an altered MMP-7/HB-EGF signaling and increased formation of elastin-like structures".
1826:
Curran ME, Atkinson DL, Ewart AK, Morris CA, Leppert MF, Keating MT (April 1993). "The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis".
2534:"Elastin as a self-organizing biomaterial: use of recombinantly expressed human elastin polypeptides as a model for investigations of structure and self-assembly of elastin"
3162:
Rodriguez-Revenga L, Iranzo P, Badenas C, Puig S, Carrió A, Milà M (September 2004). "A novel elastin gene mutation resulting in an autosomal dominant form of cutis laxa".
258:
157:
2931:"Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes"
3336:
3304:
730:
711:
3193:"Identification and characterization of seven novel mutations of elastin gene in a cohort of patients affected by supravalvular aortic stenosis"
4035:
2163:"Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves"
2227:
1720:
1702:
4015:
3984:
244:
1033:
1026:
1759:
2900:
Dyksterhuis LB, Weiss AS (June 2010). "Homology models for domains 21-23 of human tropoelastin shed light on lysine crosslinking".
221:
1085:
2495:
Jan SL, Chan SC, Fu YC, Lin SJ (June 2009). "Elastin gene study of infants with isolated congenital ductus arteriosus aneurysm".
1874:
1194:
4020:
1689:
1668:
1294:
1237:
1333:
Accumulation of fragmented elastotic material within the papillary dermis and transcutaneous elimination of elastotic fibers.
3994:
3329:
1552:
1311:
1241:
1685:
1303:
143:
118:
3716:
3620:
3595:
1596:
1320:
1664:
1508:
Tropoelastin aggregates at physiological temperature due to interactions between hydrophobic domains in a process called
4040:
3748:
3677:
3615:
3610:
68:
3666:
3625:
3512:
3507:
3502:
3496:
3415:
2823:"Fibulin-4 regulates expression of the tropoelastin gene and consequent elastic-fibre formation by human fibroblasts"
1888:
3704:
3640:
3583:
3555:
3545:
3475:
3408:
257:
156:
3693:
3428:
3390:
3322:
250:
149:
3274:
2452:"Two new elastin cross-links having pyridine skeleton. Implication of ammonia in elastin cross-linking in vivo"
2024:"Histopathology of pseudoxanthoma elasticum and related disorders: histological hallmarks and diagnostic clues"
1600:
1563:
1337:
1202:
775:
76:
3286:
756:
2753:"Association of genetic variants with chronic kidney disease in individuals with different lipid profiles"
2622:"Functional consequences of homocysteinylation of the elastic fiber proteins fibrillin-1 and tropoelastin"
1328:
1245:
2972:
Fan BJ, Figuieredo Sena DR, Pasquale LR, Grosskreutz CL, Rhee DJ, Chen TC, et al. (September 2010).
4025:
3762:
2929:
Romero R, Velez
Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, et al. (May 2010).
1592:
1299:
Degenerated elastic fibers and transepidermal perforating canals (arrow in image points at one of them)
1166:
3357:
2864:
Tintar D, Samouillan V, Dandurand J, Lacabanne C, Pepe A, Bochicchio B, Tamburro AM (November 2009).
1607:
1474:
1221:
1116:
1108:
132:
3234:
Tzaphlidou M (2004). "The role of collagen and elastin in aged skin: an image processing approach".
2303:
Souto EB, Ribeiro AF, Ferreira MI, Teixeira MC, Shimojo AA, Soriano JL, et al. (January 2020).
2122:"Collagen and elastin content in canine arteries selected from functionally different vascular beds"
55:
4030:
3589:
3119:"Cell adhesion to tropoelastin is mediated via the C-terminal GRKRK motif and integrin alphaVbeta3"
2708:
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, et al. (December 2009).
1521:
1513:
1182:
988:
984:
980:
976:
972:
968:
964:
960:
950:
946:
942:
938:
893:
889:
885:
881:
877:
873:
869:
865:
855:
851:
847:
843:
2401:
Valenzuela CD, Wagner WL, Bennett RD, Ysasi AB, Belle JM, Molter K, et al. (September 2017).
3928:
3739:
3041:
2520:
2383:
1851:
1808:
92:
1286:
1009:
934:
914:
839:
1914:
Muiznieks LD, Weiss AS, Keeley FW (April 2010). "Structural disorder and dynamics of elastin".
3933:
3743:
3534:
3296:
3251:
3222:
3179:
3150:
3105:
3084:
3033:
3003:
2974:"Lack of association of polymorphisms in elastin with pseudoexfoliation syndrome and glaucoma"
2960:
2917:
2888:
2852:
2809:
2774:
2739:
2696:
2653:
2608:
2575:
Choudhury R, McGovern A, Ridley C, Cain SA, Baldwin A, Wang MC, et al. (September 2009).
2563:
2512:
2473:
2432:
2375:
2336:
2282:
2233:
2223:
2192:
2143:
2102:
2055:
1977:
1931:
1843:
1800:
1765:
1755:
1641:
1428:
1416:
1268:
1225:
1206:
1120:
48:
3858:
3853:
3814:
3809:
3804:
3799:
3794:
3539:
3403:
3280:
3243:
3212:
3204:
3171:
3140:
3130:
3096:
Rosenbloom J (December 1984). "Elastin: relation of protein and gene structure to disease".
3074:
3066:
3025:
2993:
2985:
2950:
2942:
2909:
2880:
2842:
2834:
2799:
2764:
2729:
2721:
2686:
2678:
2643:
2633:
2598:
2588:
2553:
2545:
2504:
2463:
2422:
2414:
2367:
2326:
2316:
2272:
2264:
2215:
2182:
2174:
2133:
2092:
2045:
2035:
1967:
1923:
1835:
1792:
1747:
1630:
1470:
1280:
1276:
337:
268:
212:
167:
3055:"Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease"
3979:
3836:
3831:
3826:
3422:
3384:
1424:
1198:
1190:
1174:
312:
1599:. The expression of tropoelastin mRNA is highly regulated under at least eight different
88:
3053:
Roberts KE, Kawut SM, Krowka MJ, Brown RS, Trotter JF, Shah V, et al. (July 2010).
2865:
2821:
Chen Q, Zhang T, Roshetsky JF, Ouyang Z, Essers J, Fan C, et al. (September 2009).
2538:
Philosophical
Transactions of the Royal Society of London. Series B, Biological Sciences
3466:
3217:
3192:
3191:
Micale L, Turturo MG, Fusco C, Augello B, Jurado LA, Izzi C, et al. (March 2010).
3145:
3118:
3079:
3054:
2998:
2973:
2955:
2930:
2847:
2822:
2734:
2709:
2691:
2666:
2648:
2621:
2603:
2576:
2558:
2533:
2427:
2402:
2331:
2304:
2277:
2252:
2187:
2162:
2161:
Lammers SR, Kao PH, Qi HJ, Hunter K, Lanning C, Albietz J, et al. (October 2008).
2050:
2023:
1972:
1955:
1625:
1588:
1481:
1137:
2751:
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, et al. (August 2009).
2725:
1751:
1359:
In the body, elastin is usually associated with other proteins in connective tissues.
645:
640:
635:
630:
625:
620:
615:
610:
605:
600:
595:
590:
574:
569:
564:
559:
543:
538:
533:
528:
4009:
3767:
3349:
3308:
1839:
1812:
1545:
1532:
To make mature elastin fibres, the tropoelastin molecules are cross-linked via their
1360:
515:
3045:
2524:
2387:
1591:
assigning its extracellular localization. The large number of introns suggests that
3891:
3270:
1855:
1584:
1541:
1509:
1466:
1439:
Elastin is a very long-lived protein, with a half-life of over 78 years in humans.
1112:
330:
109:
2866:"Human tropoelastin sequence: dynamics of polypeptide coded by exon 6 in solution"
2710:"Integrative predictive model of coronary artery calcification in atherosclerosis"
1587:, and has 34 exons interrupted by almost 700 introns, with the first exon being a
80:
3247:
3070:
2989:
2403:"Extracellular Assembly of the Elastin Cable Line Element in the Developing Lung"
2371:
2219:
2214:. Advances in Experimental Medicine and Biology. Vol. 79. pp. 291–312.
1796:
96:
3969:
3898:
3634:
3579:
3175:
2788:"Soluble elastin decreases in the progress of atheroma formation in human aorta"
2178:
1725:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1707:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1517:
1493:
1489:
1485:
1141:
3291:
2946:
2913:
2786:
Akima T, Nakanishi K, Suzuki K, Katayama M, Ohsuzu F, Kawai T (November 2009).
2066:
413:
3600:
3029:
2682:
1620:
1400:
1368:
1233:
1232:, which is caused by prolonged and excessive sun exposure, a process known as
1170:
229:
126:
2804:
2787:
1892:
3135:
2638:
2593:
2508:
2305:"New Nanotechnologies for the Treatment and Repair of Skin Burns Infections"
2138:
2121:
2097:
2080:
1537:
1364:
1351:
1178:
675:
473:
351:
296:
283:
195:
182:
84:
17:
3255:
3226:
3183:
3154:
3088:
3037:
3007:
2964:
2921:
2892:
2856:
2813:
2778:
2743:
2700:
2657:
2612:
2567:
2549:
2516:
2477:
2468:
2451:
2436:
2379:
2340:
2286:
2196:
2106:
2059:
1935:
1804:
1769:
1595:
may contribute to the instability of the gene, leading to diseases such as
3314:
3208:
3109:
2769:
2752:
2147:
2040:
1999:
1981:
1847:
1073:
1068:
3752:
3731:
3368:
2620:
Hubmacher D, Cirulis JT, Miao M, Keeley FW, Reinhardt DP (January 2010).
2321:
2237:
1783:
Vindin H, Mithieux SM, Weiss AS (November 2019). "Elastin architecture".
1412:
1396:
1057:
820:
801:
2577:"Differential regulation of elastic fiber formation by fibulin-4 and -5"
1403:
and is particularly abundant in large elastic blood vessels such as the
3974:
3965:
3913:
3781:
3757:
3721:
3709:
3527:
3522:
3517:
3445:
3345:
2838:
1635:
1462:
1384:
1380:
1372:
1149:
1145:
1097:
1089:
Thick elastic fibers consisting of bundles of elastin in the human lung
787:
742:
3098:
Laboratory
Investigation; A Journal of Technical Methods and Pathology
2884:
1544:
cross-linking molecules. The enzyme that performs the crosslinking is
1152:, which form mobile hydrophobic regions bounded by crosslinks between
3918:
3682:
3655:
3650:
3645:
3570:
3565:
3560:
3550:
3485:
3480:
3438:
3433:
3395:
3287:
GeneReviews/NIH/NCBI/UW entry on
Williams or Williams-Beuren Syndrome
2418:
1572:
1533:
1376:
1153:
1041:
697:
2268:
1927:
27:
Protein allowing tissue in the body to resume shape after stretching
3943:
3938:
3908:
3903:
3881:
3863:
3841:
3450:
1404:
1350:
1224:. There are a multitude of causes, but the most commons cause is
660:
656:
3923:
2665:
Coolen NA, Schouten KC, Middelkoop E, Ulrich MM (January 2010).
2167:
American
Journal of Physiology. Heart and Circulatory Physiology
1497:
1420:
1408:
1104:
72:
3318:
2298:
2296:
2352:
2350:
1136:
gene encodes a protein that is one of the two components of
2210:
Sage EH, Gray WR (1977). "Evolution of
Elastin Structure".
1363:
in the body is a mixture of amorphous elastin and fibrous
1165:
Deletions and mutations in this gene are associated with
2532:
Keeley FW, Bellingham CM, Woodhouse KA (February 2002).
1157:
constitutive feature of elastin structure and function.
320:
3117:
Bax DV, Rodgers UR, Bilek MM, Weiss AS (October 2009).
1220:
is the buildup of elastin in tissues, and is a form of
3283: – Histology Learning System at Boston University
1516:
and thermodynamically controlled and does not require
539:
extracellular matrix constituent conferring elasticity
2079:
Kielty CM, Sherratt MJ, Shuttleworth CA (July 2002).
485:
2022:
Hosen MJ, Lamoen A, De Paepe A, Vanakker OM (2012).
1606:
Tissue specific variants of elastin are produced by
3958:
3874:
3780:
3730:
3459:
3376:
3367:
3356:
2902:
1480:Each tropoelastin consists of a string of 36 small
1002:
933:
907:
838:
2017:
2015:
2013:
1681:
1679:
1677:
1660:
1658:
1656:
1399:as a medium for pressure wave propagation to help
616:respiratory gaseous exchange by respiratory system
267:
166:
1575:only contains one gene for tropoelastin, called
1367:. Both components are primarily made of smaller
1316:Clumping of short elastic fibers in the dermis.
2667:"Comparison between human fetal and adult skin"
2253:"Protein homeostasis: live long, won't prosper"
1949:
1947:
1945:
1461:Elastin is made by linking together many small
1686:GRCm38: Ensembl release 89: ENSMUSG00000029675
1173:. Other associated defects in elastin include
646:regulation of smooth muscle cell proliferation
3330:
2935:American Journal of Obstetrics and Gynecology
1107:in humans. Elastin is a key component in the
8:
2450:Umeda H, Takeuchi M, Suyama K (April 2001).
1993:
1991:
1355:Stretched elastin isolated from bovine aorta
1236:. Uncommon causes of skin elastosis include
2757:International Journal of Molecular Medicine
2309:International Journal of Molecular Sciences
1665:GRCh38: Ensembl release 89: ENSG00000049540
1272:(most common, also called solar elastosis)
636:regulation of actin filament polymerization
529:extracellular matrix structural constituent
3373:
3364:
3337:
3323:
3315:
3305:United States National Library of Medicine
930:
835:
671:
511:
308:
207:
104:
3273:at the U.S. National Library of Medicine
3216:
3144:
3134:
3078:
2997:
2954:
2846:
2803:
2768:
2733:
2690:
2647:
2637:
2602:
2592:
2557:
2467:
2426:
2330:
2320:
2276:
2186:
2137:
2096:
2067:Creative Commons Attribution 3.0 Unported
2049:
2039:
1971:
1738:Mithieux SM, Weiss AS (2005). "Elastin".
1407:. Elastin is also very important in the
1275:Elastin replacing collagen fibers of the
3303:This article incorporates text from the
1869:
1867:
1865:
1562:
1395:Elastin serves an important function in
1250:
1084:
575:collagen-containing extracellular matrix
2120:Fischer GM, Llaurado JG (August 1966).
1652:
1496:domains, which are encoded by separate
2257:Nature Reviews. Molecular Cell Biology
1954:Vrhovski B, Weiss AS (November 1998).
1567:Domain structure of human tropoelastin
1520:. The coacervate is made insoluble by
1488:. The protein consists of alternating
1448:flexibility of the eventual scarring.
29:
2251:Toyama BH, Hetzer MW (January 2013).
272:
233:
228:
171:
130:
125:
7:
3018:Mechanisms of Ageing and Development
3985:Cartilage oligomeric matrix protein
3123:The Journal of Biological Chemistry
2671:Archives of Dermatological Research
2626:The Journal of Biological Chemistry
2581:The Journal of Biological Chemistry
2456:The Journal of Biological Chemistry
2360:Journal of Burn Care & Research
3197:European Journal of Human Genetics
1973:10.1046/j.1432-1327.1998.2580001.x
1169:(SVAS) and the autosomal dominant
1115:(jawed vertebrates). It is highly
999:
904:
811:
792:
766:
747:
721:
702:
631:skeletal muscle tissue development
490:
408:
346:
325:
25:
2726:10.1161/CIRCULATIONAHA.109.865501
1484:, each weighing about 2 kDa in a
1140:. The encoded protein is rich in
606:extracellular matrix organization
1960:European Journal of Biochemistry
1336:
1319:
1302:
1285:
601:extracellular matrix disassembly
256:
249:
243:
220:
155:
148:
142:
117:
1295:Elastosis perforans serpiginosa
1238:elastosis perforans serpiginosa
59:, SVAS, WBS, WS, elastin, ADCL1
1956:"Biochemistry of tropoelastin"
1553:Chichibabin pyridine synthesis
1312:Perforating calcific elastosis
1242:perforating calcific elastosis
474:More reference expression data
1:
4036:Extracellular matrix proteins
1916:Biochemistry and Cell Biology
1752:10.1016/S0065-3233(05)70013-9
1740:Advances in Protein Chemistry
1167:supravalvular aortic stenosis
596:cell population proliferation
440:tunica media of zone of aorta
241:
140:
3749:Cartilage associated protein
3248:10.1016/j.micron.2003.11.003
3071:10.1053/j.gastro.2010.03.044
2990:10.1097/IJG.0b013e3181c4b0fe
2372:10.1097/BCR.0000000000000507
2220:10.1007/978-1-4684-9093-0_27
1840:10.1016/0092-8674(93)90168-P
1797:10.1016/j.matbio.2019.07.005
544:extracellular matrix binding
4016:Genes on human chromosome 7
3176:10.1001/archderm.140.9.1135
2179:10.1152/ajpheart.00127.2008
1583:gene is a 45 kb segment on
1228:of the skin, also known as
1195:Buschke–Ollendorff syndrome
621:outflow tract morphogenesis
4057:
2947:10.1016/j.ajog.2010.03.026
2914:10.1016/j.bbrc.2010.05.013
2212:Elastin and Elastic Tissue
626:aortic valve morphogenesis
591:animal organ morphogenesis
3281:Histology image: 21402loa
3030:10.1016/j.mad.2009.08.001
2683:10.1007/s00403-009-0989-8
1721:"Mouse PubMed Reference:"
1703:"Human PubMed Reference:"
1638:: an invertebrate protein
1601:transcription start sites
1469:protein molecules (50-70
1072:
1067:
1063:
1056:
1040:
1034:Chr 5: 134.73 – 134.78 Mb
1021:
1006:
957:
926:
911:
862:
831:
818:
814:
799:
795:
786:
773:
769:
754:
750:
741:
728:
724:
709:
705:
696:
681:
674:
670:
654:
514:
510:
498:
493:
484:
471:
420:
411:
362:Descending thoracic aorta
358:
349:
319:
311:
307:
290:
277:
240:
219:
210:
206:
189:
176:
139:
116:
107:
103:
66:
63:
53:
46:
41:
37:
32:
3275:Medical Subject Headings
2805:10.1253/circj.cj-09-0104
1486:random coil conformation
1203:pseudoxanthoma elasticum
3164:Archives of Dermatology
3136:10.1074/jbc.M109.017525
2827:The Biochemical Journal
2639:10.1074/jbc.M109.021246
2594:10.1074/jbc.M109.019364
2509:10.2143/ac.64.3.2038023
2139:10.1161/01.res.19.2.394
2098:10.1242/jcs.115.14.2817
2085:Journal of Cell Science
1457:Tropoelastin precursors
1027:Chr 7: 74.03 – 74.07 Mb
444:internal carotid artery
436:external carotid artery
398:upper lobe of left lung
4021:Aging-related proteins
2550:10.1098/rstb.2001.1027
2469:10.1074/jbc.M009744200
1875:"Entrez Gene: elastin"
1568:
1356:
1329:Linear focal elastosis
1252:Skin elastosis causes
1246:linear focal elastosis
1090:
460:atrioventricular valve
3763:Procollagen peptidase
3209:10.1038/ejhg.2009.181
2770:10.3892/ijmm_00000226
1593:genetic recombination
1566:
1354:
1161:Clinical significance
1088:
641:stress fiber assembly
370:right coronary artery
2941:(5): 431.e1–431.34.
2322:10.3390/ijms21020393
2126:Circulation Research
2091:(Pt 14): 2817–2828.
1608:alternative splicing
1475:extracellular matrix
1260:Distinctive features
1222:degenerative disease
1144:amino acids such as
1109:extracellular matrix
570:extracellular matrix
560:extracellular region
390:left coronary artery
274:5 G2|5 74.76 cM
235:Chromosome 5 (mouse)
133:Chromosome 7 (human)
4041:Structural proteins
3292:The Elastin Protein
3129:(42): 28616–28623.
2978:Journal of Glaucoma
2792:Circulation Journal
2587:(36): 24553–24567.
2462:(16): 12579–12587.
2041:10.6064/2012/598262
1427:. It is present in
1391:Tissue distribution
1253:
3929:Matrix gla protein
3740:Prolyl hydroxylase
3307:, which is in the
2839:10.1042/BJ20090993
2173:(4): H1451–H1459.
1569:
1512:. This process is
1357:
1251:
1091:
776:ENSMUSG00000029675
584:Biological process
553:Cellular component
522:Molecular function
4003:
4002:
3954:
3953:
3776:
3775:
3744:Lysyl hydroxylase
3535:basement membrane
2885:10.1002/bip.21282
2798:(11): 2154–2162.
2720:(24): 2448–2454.
2544:(1418): 185–189.
2497:Acta Cardiologica
2407:Anatomical Record
2229:978-1-4684-9095-4
1642:Williams syndrome
1559:Molecular biology
1443:Clinical research
1429:jawed vertebrates
1417:elastic cartilage
1413:elastic ligaments
1344:
1343:
1269:Actinic elastosis
1226:actinic elastosis
1207:Williams syndrome
1121:connective tissue
1083:
1082:
1079:
1078:
1052:
1051:
1017:
1016:
996:
995:
922:
921:
901:
900:
827:
826:
808:
807:
782:
781:
763:
762:
737:
736:
718:
717:
666:
665:
611:blood circulation
506:
505:
502:
501:
480:
479:
467:
466:
456:lactiferous gland
405:
404:
303:
302:
202:
201:
16:(Redirected from
4048:
3374:
3365:
3339:
3332:
3325:
3316:
3259:
3230:
3220:
3187:
3170:(9): 1135–1139.
3158:
3148:
3138:
3113:
3092:
3082:
3065:(1): 130–9.e24.
3059:Gastroenterology
3049:
3011:
3001:
2968:
2958:
2925:
2896:
2870:
2860:
2850:
2817:
2807:
2782:
2772:
2747:
2737:
2704:
2694:
2661:
2651:
2641:
2632:(2): 1188–1198.
2616:
2606:
2596:
2571:
2561:
2528:
2482:
2481:
2471:
2447:
2441:
2440:
2430:
2419:10.1002/ar.23603
2413:(9): 1670–1679.
2398:
2392:
2391:
2366:(5): e859–e867.
2354:
2345:
2344:
2334:
2324:
2300:
2291:
2290:
2280:
2248:
2242:
2241:
2207:
2201:
2200:
2190:
2158:
2152:
2151:
2141:
2117:
2111:
2110:
2100:
2081:"Elastic fibres"
2076:
2070:
2063:
2053:
2043:
2019:
2008:
2007:
1995:
1986:
1985:
1975:
1951:
1940:
1939:
1911:
1905:
1904:
1902:
1900:
1895:on 13 March 2017
1891:. Archived from
1885:
1879:
1878:
1871:
1860:
1859:
1823:
1817:
1816:
1780:
1774:
1773:
1735:
1729:
1728:
1717:
1711:
1710:
1699:
1693:
1683:
1672:
1662:
1631:Elastin receptor
1571:In mammals, the
1518:protein cleavage
1340:
1323:
1306:
1289:
1281:reticular dermis
1277:papillary dermis
1254:
1065:
1064:
1036:
1029:
1012:
1000:
991:
931:
927:RefSeq (protein)
917:
905:
896:
836:
812:
793:
767:
748:
722:
703:
672:
512:
491:
476:
416:
414:Top expressed in
409:
378:popliteal artery
354:
352:Top expressed in
347:
326:
309:
299:
286:
275:
260:
253:
247:
236:
224:
208:
198:
185:
174:
159:
152:
146:
135:
121:
105:
99:
58:
51:
30:
21:
4056:
4055:
4051:
4050:
4049:
4047:
4046:
4045:
4006:
4005:
4004:
3999:
3950:
3870:
3772:
3726:
3609:transmembrane:
3455:
3359:
3352:
3343:
3267:
3262:
3233:
3190:
3161:
3116:
3095:
3052:
3024:(10): 657–669.
3014:
2971:
2928:
2899:
2879:(11): 943–952.
2868:
2863:
2820:
2785:
2750:
2707:
2664:
2619:
2574:
2531:
2494:
2490:
2488:Further reading
2485:
2449:
2448:
2444:
2400:
2399:
2395:
2356:
2355:
2348:
2302:
2301:
2294:
2269:10.1038/nrm3496
2250:
2249:
2245:
2230:
2209:
2208:
2204:
2160:
2159:
2155:
2119:
2118:
2114:
2078:
2077:
2073:
2064:
2021:
2020:
2011:
1997:
1996:
1989:
1953:
1952:
1943:
1928:10.1139/o09-161
1913:
1912:
1908:
1898:
1896:
1889:"Elastin (ELN)"
1887:
1886:
1882:
1873:
1872:
1863:
1825:
1824:
1820:
1782:
1781:
1777:
1762:
1737:
1736:
1732:
1719:
1718:
1714:
1701:
1700:
1696:
1684:
1675:
1663:
1654:
1650:
1617:
1561:
1530:
1506:
1459:
1454:
1445:
1437:
1435:Characteristics
1393:
1349:
1271:
1263:Histopathology
1230:solar elastosis
1215:
1199:Menkes syndrome
1191:atherosclerosis
1186:
1175:Marfan syndrome
1163:
1130:
1119:and present in
1100:encoded by the
1074:View/Edit Mouse
1069:View/Edit Human
1032:
1025:
1022:Location (UCSC)
1008:
987:
983:
979:
975:
971:
967:
963:
959:
953:
949:
945:
941:
937:
913:
892:
888:
884:
880:
876:
872:
868:
864:
858:
854:
850:
846:
842:
757:ENSG00000049540
650:
579:
548:
534:protein binding
472:
463:
458:
454:
450:
446:
442:
438:
434:
430:
426:
424:ascending aorta
412:
401:
396:
392:
388:
384:
382:tibial arteries
380:
376:
372:
368:
366:ascending aorta
364:
350:
294:
281:
273:
263:
262:
261:
254:
234:
211:Gene location (
193:
180:
172:
162:
161:
160:
153:
131:
108:Gene location (
97:ELN - orthologs
67:
54:
47:
28:
23:
22:
15:
12:
11:
5:
4054:
4052:
4044:
4043:
4038:
4033:
4028:
4023:
4018:
4008:
4007:
4001:
4000:
3998:
3997:
3992:
3988:
3987:
3982:
3977:
3972:
3962:
3960:
3956:
3955:
3952:
3951:
3949:
3948:
3947:
3946:
3941:
3931:
3926:
3921:
3916:
3911:
3906:
3901:
3896:
3895:
3894:
3884:
3878:
3876:
3872:
3871:
3869:
3868:
3867:
3866:
3861:
3856:
3846:
3845:
3844:
3839:
3834:
3829:
3819:
3818:
3817:
3812:
3807:
3802:
3797:
3786:
3784:
3778:
3777:
3774:
3773:
3771:
3770:
3765:
3760:
3755:
3746:
3736:
3734:
3728:
3727:
3725:
3724:
3719:
3714:
3713:
3712:
3707:
3697:
3687:
3686:
3685:
3680:
3670:
3660:
3659:
3658:
3653:
3648:
3643:
3629:
3628:
3623:
3618:
3613:
3606:
3605:
3604:
3603:
3598:
3586:
3576:
3575:
3574:
3573:
3568:
3563:
3558:
3553:
3548:
3531:
3530:
3525:
3520:
3515:
3510:
3505:
3500:
3490:
3489:
3488:
3483:
3478:
3463:
3461:
3457:
3456:
3454:
3453:
3448:
3443:
3442:
3441:
3436:
3431:
3419:
3412:
3400:
3399:
3398:
3393:
3380:
3378:
3377:Fibril forming
3371:
3362:
3358:Extracellular
3354:
3353:
3350:scleroproteins
3344:
3342:
3341:
3334:
3327:
3319:
3300:
3299:
3294:
3289:
3284:
3278:
3266:
3265:External links
3263:
3261:
3260:
3242:(3): 173–177.
3231:
3203:(3): 317–323.
3188:
3159:
3114:
3104:(6): 605–623.
3093:
3050:
3012:
2984:(7): 432–436.
2969:
2926:
2908:(4): 870–873.
2897:
2861:
2818:
2783:
2763:(2): 233–246.
2748:
2705:
2662:
2617:
2572:
2529:
2503:(3): 363–369.
2491:
2489:
2486:
2484:
2483:
2442:
2393:
2346:
2292:
2243:
2228:
2202:
2153:
2132:(2): 394–399.
2112:
2071:
2009:
1987:
1941:
1922:(2): 239–250.
1906:
1880:
1861:
1834:(1): 159–168.
1818:
1785:Matrix Biology
1775:
1760:
1730:
1712:
1694:
1673:
1651:
1649:
1646:
1645:
1644:
1639:
1633:
1628:
1626:Elastic fibers
1623:
1616:
1613:
1589:signal peptide
1560:
1557:
1536:residues with
1529:
1526:
1524:crosslinking.
1505:
1502:
1458:
1455:
1453:
1450:
1444:
1441:
1436:
1433:
1392:
1389:
1348:
1345:
1342:
1341:
1334:
1331:
1325:
1324:
1317:
1314:
1308:
1307:
1300:
1297:
1291:
1290:
1283:
1273:
1265:
1264:
1261:
1258:
1214:
1211:
1184:
1162:
1159:
1138:elastic fibers
1129:
1126:
1081:
1080:
1077:
1076:
1071:
1061:
1060:
1054:
1053:
1050:
1049:
1047:
1045:
1038:
1037:
1030:
1023:
1019:
1018:
1015:
1014:
1004:
1003:
997:
994:
993:
955:
954:
928:
924:
923:
920:
919:
909:
908:
902:
899:
898:
860:
859:
833:
829:
828:
825:
824:
816:
815:
809:
806:
805:
797:
796:
790:
784:
783:
780:
779:
771:
770:
764:
761:
760:
752:
751:
745:
739:
738:
735:
734:
726:
725:
719:
716:
715:
707:
706:
700:
694:
693:
688:
683:
679:
678:
668:
667:
664:
663:
652:
651:
649:
648:
643:
638:
633:
628:
623:
618:
613:
608:
603:
598:
593:
587:
585:
581:
580:
578:
577:
572:
567:
562:
556:
554:
550:
549:
547:
546:
541:
536:
531:
525:
523:
519:
518:
508:
507:
504:
503:
500:
499:
496:
495:
488:
482:
481:
478:
477:
469:
468:
465:
464:
462:
461:
457:
453:
449:
445:
441:
437:
433:
432:left lung lobe
429:
425:
421:
418:
417:
406:
403:
402:
400:
399:
395:
391:
387:
386:gastric mucosa
383:
379:
375:
371:
367:
363:
359:
356:
355:
343:
342:
334:
323:
317:
316:
313:RNA expression
305:
304:
301:
300:
292:
288:
287:
279:
276:
271:
265:
264:
255:
248:
242:
238:
237:
232:
226:
225:
217:
216:
204:
203:
200:
199:
191:
187:
186:
178:
175:
170:
164:
163:
154:
147:
141:
137:
136:
129:
123:
122:
114:
113:
101:
100:
65:
61:
60:
52:
44:
43:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4053:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4013:
4011:
3996:
3993:
3990:
3989:
3986:
3983:
3981:
3978:
3976:
3973:
3971:
3967:
3964:
3963:
3961:
3957:
3945:
3942:
3940:
3937:
3936:
3935:
3932:
3930:
3927:
3925:
3922:
3920:
3917:
3915:
3912:
3910:
3907:
3905:
3902:
3900:
3897:
3893:
3890:
3889:
3888:
3885:
3883:
3880:
3879:
3877:
3873:
3865:
3862:
3860:
3857:
3855:
3852:
3851:
3850:
3847:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3824:
3823:
3820:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3792:
3791:
3788:
3787:
3785:
3783:
3779:
3769:
3768:Lysyl oxidase
3766:
3764:
3761:
3759:
3756:
3754:
3750:
3747:
3745:
3741:
3738:
3737:
3735:
3733:
3729:
3723:
3720:
3718:
3715:
3711:
3708:
3706:
3703:
3702:
3701:
3698:
3695:
3691:
3688:
3684:
3681:
3679:
3676:
3675:
3674:
3671:
3668:
3664:
3661:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3638:
3637:
3636:
3631:
3630:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3608:
3607:
3602:
3599:
3597:
3594:
3593:
3592:
3591:
3587:
3585:
3581:
3578:
3577:
3572:
3569:
3567:
3564:
3562:
3559:
3557:
3554:
3552:
3549:
3547:
3544:
3543:
3542:
3541:
3536:
3533:
3532:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3498:
3494:
3491:
3487:
3484:
3482:
3479:
3477:
3474:
3473:
3472:
3468:
3465:
3464:
3462:
3458:
3452:
3449:
3447:
3444:
3440:
3437:
3435:
3432:
3430:
3427:
3426:
3425:
3424:
3420:
3418:
3417:
3413:
3410:
3406:
3405:
3401:
3397:
3394:
3392:
3389:
3388:
3387:
3386:
3382:
3381:
3379:
3375:
3372:
3370:
3366:
3363:
3361:
3355:
3351:
3347:
3340:
3335:
3333:
3328:
3326:
3321:
3320:
3317:
3313:
3312:
3310:
3309:public domain
3306:
3298:
3295:
3293:
3290:
3288:
3285:
3282:
3279:
3276:
3272:
3269:
3268:
3264:
3257:
3253:
3249:
3245:
3241:
3237:
3232:
3228:
3224:
3219:
3214:
3210:
3206:
3202:
3198:
3194:
3189:
3185:
3181:
3177:
3173:
3169:
3165:
3160:
3156:
3152:
3147:
3142:
3137:
3132:
3128:
3124:
3120:
3115:
3111:
3107:
3103:
3099:
3094:
3090:
3086:
3081:
3076:
3072:
3068:
3064:
3060:
3056:
3051:
3047:
3043:
3039:
3035:
3031:
3027:
3023:
3019:
3013:
3009:
3005:
3000:
2995:
2991:
2987:
2983:
2979:
2975:
2970:
2966:
2962:
2957:
2952:
2948:
2944:
2940:
2936:
2932:
2927:
2923:
2919:
2915:
2911:
2907:
2903:
2898:
2894:
2890:
2886:
2882:
2878:
2874:
2867:
2862:
2858:
2854:
2849:
2844:
2840:
2836:
2832:
2828:
2824:
2819:
2815:
2811:
2806:
2801:
2797:
2793:
2789:
2784:
2780:
2776:
2771:
2766:
2762:
2758:
2754:
2749:
2745:
2741:
2736:
2731:
2727:
2723:
2719:
2715:
2711:
2706:
2702:
2698:
2693:
2688:
2684:
2680:
2676:
2672:
2668:
2663:
2659:
2655:
2650:
2645:
2640:
2635:
2631:
2627:
2623:
2618:
2614:
2610:
2605:
2600:
2595:
2590:
2586:
2582:
2578:
2573:
2569:
2565:
2560:
2555:
2551:
2547:
2543:
2539:
2535:
2530:
2526:
2522:
2518:
2514:
2510:
2506:
2502:
2498:
2493:
2492:
2487:
2479:
2475:
2470:
2465:
2461:
2457:
2453:
2446:
2443:
2438:
2434:
2429:
2424:
2420:
2416:
2412:
2408:
2404:
2397:
2394:
2389:
2385:
2381:
2377:
2373:
2369:
2365:
2361:
2353:
2351:
2347:
2342:
2338:
2333:
2328:
2323:
2318:
2314:
2310:
2306:
2299:
2297:
2293:
2288:
2284:
2279:
2274:
2270:
2266:
2262:
2258:
2254:
2247:
2244:
2239:
2235:
2231:
2225:
2221:
2217:
2213:
2206:
2203:
2198:
2194:
2189:
2184:
2180:
2176:
2172:
2168:
2164:
2157:
2154:
2149:
2145:
2140:
2135:
2131:
2127:
2123:
2116:
2113:
2108:
2104:
2099:
2094:
2090:
2086:
2082:
2075:
2072:
2068:
2061:
2057:
2052:
2047:
2042:
2037:
2033:
2029:
2025:
2018:
2016:
2014:
2010:
2005:
2001:
1994:
1992:
1988:
1983:
1979:
1974:
1969:
1965:
1961:
1957:
1950:
1948:
1946:
1942:
1937:
1933:
1929:
1925:
1921:
1917:
1910:
1907:
1894:
1890:
1884:
1881:
1876:
1870:
1868:
1866:
1862:
1857:
1853:
1849:
1845:
1841:
1837:
1833:
1829:
1822:
1819:
1814:
1810:
1806:
1802:
1798:
1794:
1790:
1786:
1779:
1776:
1771:
1767:
1763:
1761:9780120342709
1757:
1753:
1749:
1745:
1741:
1734:
1731:
1726:
1722:
1716:
1713:
1708:
1704:
1698:
1695:
1691:
1687:
1682:
1680:
1678:
1674:
1670:
1666:
1661:
1659:
1657:
1653:
1647:
1643:
1640:
1637:
1634:
1632:
1629:
1627:
1624:
1622:
1619:
1618:
1614:
1612:
1609:
1604:
1602:
1598:
1594:
1590:
1586:
1582:
1578:
1574:
1565:
1558:
1556:
1554:
1551:
1547:
1546:lysyl oxidase
1543:
1539:
1535:
1527:
1525:
1523:
1519:
1515:
1511:
1503:
1501:
1499:
1495:
1491:
1487:
1483:
1478:
1476:
1472:
1468:
1464:
1456:
1451:
1449:
1442:
1440:
1434:
1432:
1430:
1426:
1422:
1418:
1414:
1410:
1406:
1402:
1398:
1390:
1388:
1386:
1382:
1378:
1374:
1370:
1366:
1362:
1361:Elastic fiber
1353:
1346:
1339:
1335:
1332:
1330:
1327:
1326:
1322:
1318:
1315:
1313:
1310:
1309:
1305:
1301:
1298:
1296:
1293:
1292:
1288:
1284:
1282:
1278:
1274:
1270:
1267:
1266:
1262:
1259:
1256:
1255:
1249:
1247:
1243:
1239:
1235:
1231:
1227:
1223:
1219:
1212:
1210:
1208:
1204:
1200:
1196:
1192:
1188:
1180:
1176:
1172:
1168:
1160:
1158:
1155:
1151:
1147:
1143:
1139:
1135:
1127:
1125:
1122:
1118:
1114:
1110:
1106:
1103:
1099:
1095:
1087:
1075:
1070:
1066:
1062:
1059:
1055:
1048:
1046:
1043:
1039:
1035:
1031:
1028:
1024:
1020:
1013:
1011:
1005:
1001:
998:
992:
990:
986:
982:
978:
974:
970:
966:
962:
956:
952:
948:
944:
940:
936:
932:
929:
925:
918:
916:
910:
906:
903:
897:
895:
891:
887:
883:
879:
875:
871:
867:
861:
857:
853:
849:
845:
841:
837:
834:
832:RefSeq (mRNA)
830:
823:
822:
817:
813:
810:
804:
803:
798:
794:
791:
789:
785:
778:
777:
772:
768:
765:
759:
758:
753:
749:
746:
744:
740:
733:
732:
727:
723:
720:
714:
713:
708:
704:
701:
699:
695:
692:
689:
687:
684:
680:
677:
673:
669:
662:
658:
653:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
597:
594:
592:
589:
588:
586:
583:
582:
576:
573:
571:
568:
566:
565:elastic fiber
563:
561:
558:
557:
555:
552:
551:
545:
542:
540:
537:
535:
532:
530:
527:
526:
524:
521:
520:
517:
516:Gene ontology
513:
509:
497:
492:
489:
487:
483:
475:
470:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
422:
419:
415:
410:
407:
397:
394:right auricle
393:
389:
385:
381:
377:
373:
369:
365:
361:
360:
357:
353:
348:
345:
344:
341:
339:
335:
333:
332:
328:
327:
324:
322:
318:
314:
310:
306:
298:
293:
289:
285:
280:
270:
266:
259:
252:
246:
239:
231:
227:
223:
218:
214:
209:
205:
197:
192:
188:
184:
179:
169:
165:
158:
151:
145:
138:
134:
128:
124:
120:
115:
111:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
4026:Biomaterials
3892:Tropoelastin
3886:
3848:
3821:
3789:
3699:
3689:
3672:
3662:
3633:
3588:
3538:
3492:
3470:
3421:
3414:
3402:
3383:
3302:
3301:
3297:Microfibril
3239:
3235:
3200:
3196:
3167:
3163:
3126:
3122:
3101:
3097:
3062:
3058:
3021:
3017:
2981:
2977:
2938:
2934:
2905:
2901:
2876:
2872:
2833:(1): 79–89.
2830:
2826:
2795:
2791:
2760:
2756:
2717:
2713:
2677:(1): 47–55.
2674:
2670:
2629:
2625:
2584:
2580:
2541:
2537:
2500:
2496:
2459:
2455:
2445:
2410:
2406:
2396:
2363:
2359:
2312:
2308:
2263:(1): 55–61.
2260:
2256:
2246:
2211:
2205:
2170:
2166:
2156:
2129:
2125:
2115:
2088:
2084:
2074:
2031:
2027:
2003:
1963:
1959:
1919:
1915:
1909:
1897:. Retrieved
1893:the original
1883:
1831:
1827:
1821:
1788:
1784:
1778:
1743:
1739:
1733:
1724:
1715:
1706:
1697:
1605:
1585:chromosome 7
1580:
1579:. The human
1576:
1570:
1549:
1542:isodesmosine
1531:
1528:Crosslinking
1522:irreversible
1510:coacervation
1507:
1479:
1467:tropoelastin
1460:
1452:Biosynthesis
1446:
1438:
1394:
1358:
1229:
1217:
1216:
1189:deficiency,
1187:-antitrypsin
1164:
1133:
1131:
1113:gnathostomes
1101:
1093:
1092:
1007:
989:NP_001265868
985:NP_001265847
981:NP_001265846
977:NP_001265845
973:NP_001265844
969:NP_001265843
965:NP_001265842
961:NP_001265841
958:
951:NP_001075224
947:NP_001075223
943:NP_001075222
939:NP_001075221
912:
894:NM_001278939
890:NM_001278918
886:NM_001278917
882:NM_001278916
878:NM_001278915
874:NM_001278914
870:NM_001278913
866:NM_001278912
863:
856:NM_001081755
852:NM_001081754
848:NM_001081753
844:NM_001081752
819:
800:
774:
755:
729:
710:
690:
685:
428:aortic valve
336:
329:
295:134,776,177
282:134,731,447
64:External IDs
18:Tropoelastin
3970:Cytokeratin
3899:Vitronectin
3580:multiplexin
2873:Biopolymers
2714:Circulation
2028:Scientifica
2000:"Elastosis"
1966:(1): 1–18.
1746:: 437–461.
1548:, using an
1504:Aggregation
1494:hydrophilic
1490:hydrophobic
1369:amino acids
1347:Composition
1142:hydrophobic
448:optic nerve
194:74,069,907
181:74,027,789
42:Identifiers
4031:Elastomers
4010:Categories
3601:Endostatin
3590:type XVIII
2315:(2): 393.
2034:: 598262.
2004:DermNet NZ
1998:Wright B.
1899:31 October
1692:, May 2017
1671:, May 2017
1648:References
1621:Cutis laxa
1555:reaction.
1514:reversible
1465:precursor
1423:, and the
1401:blood flow
1234:photoaging
1181:caused by
1171:cutis laxa
452:belly cord
374:right lung
340:(ortholog)
3980:Reticulin
3673:type VIII
1813:196458819
1538:desmosine
1365:fibrillin
1257:Condition
1218:Elastosis
1213:Elastosis
1179:emphysema
1010:NP_031951
935:NP_000492
915:NM_007925
840:NM_000501
676:Orthologs
85:GeneCards
3995:diseases
3991:See also
3934:Tectorin
3753:Leprecan
3663:type VII
3493:type XII
3416:type III
3369:Collagen
3256:15036271
3227:19844261
3184:15381555
3155:19617625
3089:20346360
3046:46477586
3038:19682489
3008:20051886
2965:20452482
2922:20457133
2893:19603496
2857:19627254
2814:19755752
2779:19578796
2744:19948975
2701:19701759
2658:19889633
2613:19570982
2568:11911775
2525:31411296
2517:19593948
2478:11278561
2437:28380679
2388:39251937
2380:28221299
2341:31936277
2287:23258296
2197:18660454
2107:12082143
2060:24278718
1936:20453927
1805:31301399
1791:: 4–16.
1770:15837523
1688:–
1667:–
1615:See also
1397:arteries
1371:such as
1128:Function
1058:Wikidata
655:Sources:
3975:Gelatin
3966:Keratin
3914:Decorin
3887:Elastin
3782:Laminin
3758:ADAMTS2
3732:Enzymes
3722:COL28A1
3717:COL27A1
3710:COL11A2
3705:COL11A1
3700:type XI
3694:COL10A1
3635:type VI
3632:other:
3626:COL25A1
3621:COL23A1
3616:COL17A1
3611:COL13A1
3596:COL18A1
3584:COL15A1
3540:type IV
3528:COL22A1
3523:COL21A1
3518:COL20A1
3513:COL19A1
3508:COL16A1
3503:COL14A1
3497:COL12A1
3471:type IX
3451:COL26A1
3446:COL24A1
3404:type II
3346:Protein
3271:Elastin
3218:2987220
3146:2781405
3110:6150137
3080:2908261
2999:6748032
2956:3604889
2848:3024593
2735:2810344
2692:2799629
2649:2801247
2604:2782046
2559:1692930
2428:6315300
2332:7013843
2278:3570024
2188:2593497
2148:5914851
2069:license
2051:3820553
1982:9851686
1856:8274849
1848:8096434
1690:Ensembl
1669:Ensembl
1636:Resilin
1550:in vivo
1482:domains
1463:soluble
1425:bladder
1385:proline
1381:alanine
1373:glycine
1150:proline
1146:glycine
1117:elastic
1098:protein
1094:Elastin
788:UniProt
743:Ensembl
682:Species
661:QuickGO
315:pattern
173:7q11.23
49:Aliases
3919:FAM20C
3690:type X
3683:COL8A2
3678:COL8A1
3667:COL7A1
3656:COL6A5
3651:COL6A3
3646:COL6A2
3641:COL6A1
3571:COL4A6
3566:COL4A5
3561:COL4A4
3556:COL4A3
3551:COL4A2
3546:COL4A1
3486:COL9A3
3481:COL9A2
3476:COL9A1
3439:COL5A3
3434:COL5A2
3429:COL5A1
3423:type V
3409:COL2A1
3396:COL1A2
3391:COL1A1
3385:type I
3360:matrix
3277:(MeSH)
3254:
3236:Micron
3225:
3215:
3182:
3153:
3143:
3108:
3087:
3077:
3044:
3036:
3006:
2996:
2963:
2953:
2920:
2891:
2855:
2845:
2812:
2777:
2742:
2732:
2699:
2689:
2656:
2646:
2611:
2601:
2566:
2556:
2523:
2515:
2476:
2435:
2425:
2386:
2378:
2339:
2329:
2285:
2275:
2238:868643
2236:
2226:
2195:
2185:
2146:
2105:
2058:
2048:
1980:
1934:
1854:
1846:
1811:
1803:
1768:
1758:
1573:genome
1534:lysine
1419:, the
1383:, and
1377:valine
1205:, and
1154:lysine
1044:search
1042:PubMed
821:P54320
802:P15502
698:Entrez
486:BioGPS
73:130160
3959:Other
3944:TECTB
3939:TECTA
3909:FREM2
3904:FRAS1
3882:ALCAM
3875:Other
3864:LAMC3
3859:LAMC2
3854:LAMC1
3849:gamma
3842:LAMB4
3837:LAMB3
3832:LAMB2
3827:LAMB1
3815:LAMA5
3810:LAMA4
3805:LAMA3
3800:LAMA2
3795:LAMA1
3790:alpha
3467:FACIT
3460:Other
3042:S2CID
2869:(PDF)
2521:S2CID
2384:S2CID
1852:S2CID
1809:S2CID
1498:exons
1409:lungs
1405:aorta
1096:is a
731:13717
691:Mouse
686:Human
657:Amigo
338:Mouse
331:Human
278:Start
213:Mouse
177:Start
110:Human
81:95317
3924:ECM1
3822:beta
3252:PMID
3223:PMID
3180:PMID
3151:PMID
3106:PMID
3085:PMID
3034:PMID
3004:PMID
2961:PMID
2918:PMID
2889:PMID
2853:PMID
2810:PMID
2775:PMID
2740:PMID
2697:PMID
2654:PMID
2609:PMID
2564:PMID
2513:PMID
2474:PMID
2433:PMID
2376:PMID
2337:PMID
2283:PMID
2234:PMID
2224:ISBN
2193:PMID
2144:PMID
2103:PMID
2056:PMID
2032:2012
1978:PMID
1932:PMID
1901:2011
1844:PMID
1828:Cell
1801:PMID
1766:PMID
1756:ISBN
1597:SVAS
1540:and
1492:and
1421:skin
1279:and
1244:and
1148:and
1132:The
1105:gene
712:2006
321:Bgee
269:Band
230:Chr.
168:Band
127:Chr.
69:OMIM
3244:doi
3213:PMC
3205:doi
3172:doi
3168:140
3141:PMC
3131:doi
3127:284
3075:PMC
3067:doi
3063:139
3026:doi
3022:130
2994:PMC
2986:doi
2951:PMC
2943:doi
2939:202
2910:doi
2906:396
2881:doi
2843:PMC
2835:doi
2831:423
2800:doi
2765:doi
2730:PMC
2722:doi
2718:120
2687:PMC
2679:doi
2675:302
2644:PMC
2634:doi
2630:285
2599:PMC
2589:doi
2585:284
2554:PMC
2546:doi
2542:357
2505:doi
2464:doi
2460:276
2423:PMC
2415:doi
2411:300
2368:doi
2327:PMC
2317:doi
2273:PMC
2265:doi
2216:doi
2183:PMC
2175:doi
2171:295
2134:doi
2093:doi
2089:115
2046:PMC
2036:doi
1968:doi
1964:258
1924:doi
1836:doi
1793:doi
1748:doi
1581:ELN
1577:ELN
1471:kDa
1134:ELN
1111:of
1102:ELN
494:n/a
291:End
190:End
93:OMA
89:ELN
77:MGI
56:ELN
33:ELN
4012::
3582::
3537::
3469::
3348::
3250:.
3240:35
3238:.
3221:.
3211:.
3201:18
3199:.
3195:.
3178:.
3166:.
3149:.
3139:.
3125:.
3121:.
3102:51
3100:.
3083:.
3073:.
3061:.
3057:.
3040:.
3032:.
3020:.
3002:.
2992:.
2982:19
2980:.
2976:.
2959:.
2949:.
2937:.
2933:.
2916:.
2904:.
2887:.
2877:91
2875:.
2871:.
2851:.
2841:.
2829:.
2825:.
2808:.
2796:73
2794:.
2790:.
2773:.
2761:24
2759:.
2755:.
2738:.
2728:.
2716:.
2712:.
2695:.
2685:.
2673:.
2669:.
2652:.
2642:.
2628:.
2624:.
2607:.
2597:.
2583:.
2579:.
2562:.
2552:.
2540:.
2536:.
2519:.
2511:.
2501:64
2499:.
2472:.
2458:.
2454:.
2431:.
2421:.
2409:.
2405:.
2382:.
2374:.
2364:38
2362:.
2349:^
2335:.
2325:.
2313:21
2311:.
2307:.
2295:^
2281:.
2271:.
2261:14
2259:.
2255:.
2232:.
2222:.
2191:.
2181:.
2169:.
2165:.
2142:.
2130:19
2128:.
2124:.
2101:.
2087:.
2083:.
2054:.
2044:.
2030:.
2026:.
2012:^
2002:.
1990:^
1976:.
1962:.
1958:.
1944:^
1930:.
1920:88
1918:.
1864:^
1850:.
1842:.
1832:73
1830:.
1807:.
1799:.
1789:84
1787:.
1764:.
1754:.
1744:70
1742:.
1723:.
1705:.
1676:^
1655:^
1603:.
1477:.
1431:.
1415:,
1411:,
1379:,
1375:,
1248:.
1240:,
1209:.
1201:,
1197:,
1193:,
1177:,
659:/
297:bp
284:bp
196:bp
183:bp
91:;
87::
83:;
79::
75:;
71::
3968:/
3751:/
3742:/
3696:)
3692:(
3669:)
3665:(
3499:)
3495:(
3411:)
3407:(
3338:e
3331:t
3324:v
3311:.
3258:.
3246::
3229:.
3207::
3186:.
3174::
3157:.
3133::
3112:.
3091:.
3069::
3048:.
3028::
3010:.
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2967:.
2945::
2924:.
2912::
2895:.
2883::
2859:.
2837::
2816:.
2802::
2781:.
2767::
2746:.
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