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which was fragile and unreliable. The relatively crude nature of these devices also meant that the particles that they generated were relatively large, too large for effective drug delivery to the lungs. None the less these nebulisers paved the way for inhaltion drug delivery providing the
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propellant and the metering valve which was originally designed for dispencing perfume. The initial design by Riker used a glass canister coated with a vinyl plastic to improve it's resilience. By 1956 Riker had developed two MDI based products, the
Medihaler-Ept containing
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43:. At that time MDI's represented a convergence of two relatively new technologies, the
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Before the invention of the MDI asthma medication was delivered using a squeeze bulb
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MDI's were first developed in the 1955 by Riker
Laboratories, now a subsidiary of
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139:(3rd Illustrated ed.). Informa Health Care. p. 1170.
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135:Swarbrick, James (2007).
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