328:
305:
202:
227:
579:
31:
334:
233:
3189:
1507:
Tan KB, Harrop J, Reddy M, Young P, Terrett J, Emery J, Moore G, Truneh A (Dec 1997). "Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells".
57:
1582:"TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like protease"
1688:
Migone TS, Zhang J, Luo X, Zhuang L, Chen C, Hu B, Hong JS, Perry JW, Chen SF, Zhou JX, Cho YH, Ullrich S, Kanakaraj P, Carrell J, Boyd E, Olsen HS, Hu G, Pukac L, Liu D, Ni J, Kim S, Gentz R, Feng P, Moore PA, Ruben SM, Wei P (Mar 2002).
1615:
Haridas V, Shrivastava A, Su J, Yu GL, Ni J, Liu D, Chen SF, Ni Y, Ruben SM, Gentz R, Aggarwal BB (Nov 1999). "VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth".
2030:
Cassatella MA, Pereira-da-Silva G, da Silva GP, Tinazzi I, Facchetti F, Scapini P, Calzetti F, Tamassia N, Wei P, Nardelli B, Roschke V, Vecchi A, Mantovani A, Bambara LM, Edwards SW, Carletto A (Jun 2007).
1965:
Yao JJ, Zhang M, Miao XH, Zhao P, Zhu SY, Ding H, Qi ZT (Apr 2006). "Isoform of vascular endothelial cell growth inhibitor (VEGI72-251) increases interleukin-2 production by activation of T lymphocytes".
1866:
Kang YJ, Kim WJ, Bae HU, Kim DI, Park YB, Park JE, Kwon BS, Lee WH (Mar 2005). "Involvement of TL1A and DR3 in induction of pro-inflammatory cytokines and matrix metalloproteinase-9 in atherogenesis".
1930:
Yamazaki K, McGovern D, Ragoussis J, Paolucci M, Butler H, Jewell D, Cardon L, Takazoe M, Tanaka T, Ichimori T, Saito S, Sekine A, Iida A, Takahashi A, Tsunoda T, Lathrop M, Nakamura Y (Nov 2005).
1837:
Prehn JL, Mehdizadeh S, Landers CJ, Luo X, Cha SC, Wei P, Targan SR (Jul 2004). "Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation".
2336:
2120:
341:
240:
2352:
1185:
inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.
2814:
2280:
2402:
2834:
2462:
2113:
812:
793:
163:
1537:
Zhai Y, Ni J, Jiang GW, Lu J, Xing L, Lincoln C, Carter KC, Janat F, Kozak D, Xu S, Rojas L, Aggarwal BB, Ruben S, Li LY, Gentz R, Yu GL (Jan 1999).
2805:
2794:
2770:
2260:
1802:
Bamias G, Martin C, Marini M, Hoang S, Mishina M, Ross WG, Sachedina MA, Friel CM, Mize J, Bickston SJ, Pizarro TT, Wei P, Cominelli F (Nov 2003).
134:, TL1, TL1A, VEGI, VEGI192A, Vascular endothelial growth inhibitor, TNLG1B, tumor necrosis factor superfamily member 15, TNF superfamily member 15
1539:"VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo"
3263:
2149:
1280:
3234:
2296:
2106:
1262:
3253:
2428:
1020:
327:
2160:
3114:
1027:
304:
1342:
1580:
Yue TL, Ni J, Romanic AM, Gu JL, Keller P, Wang C, Kumar S, Yu GL, Hart TK, Wang X, Xia Z, DeWolf WE, Feuerstein GZ (Jan 1999).
1249:
1228:
2825:
2527:
1197:
1245:
226:
201:
54:
1897:"VEGI-192, a new isoform of TNFSF15, specifically eliminates tumor vascular endothelial cells and suppresses tumor growth"
1804:"Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease"
1224:
1181:
in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an
3129:
2066:
Jin T, Guo F, Kim S, Howard A, Zhang YZ (Dec 2007). "X-ray crystal structure of TNF ligand family member TL1A at 2.1A".
143:
340:
239:
333:
232:
3119:
2761:
1201:
3227:
2720:
2190:
857:
151:
2033:"Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis"
2473:
2169:
838:
2185:
2858:
2670:
2665:
2616:
1138:
1118:
2255:
2270:
1997:"The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells"
1769:"TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells"
3220:
2785:
2621:
2326:
2220:
1655:"Modulation of endothelial cell growth arrest and apoptosis by vascular endothelial growth inhibitor"
215:
130:
3028:
2736:
2626:
2518:
2235:
2230:
2225:
2215:
978:
931:
2489:
2347:
2316:
3258:
2650:
2645:
2611:
2606:
2552:
2367:
2140:
2132:
1755:
1641:
1568:
1456:"Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease"
175:
3139:
2443:
2433:
2423:
2357:
2306:
1003:
982:
952:
927:
3068:
3058:
3048:
2985:
2710:
2413:
3078:
3063:
2980:
2945:
2690:
2195:
2129:
2083:
2054:
2018:
1983:
1953:
1918:
1883:
1854:
1825:
1790:
1747:
1712:
1676:
1633:
1603:
1560:
1525:
1485:
1436:
1387:
1321:
578:
123:
47:
3204:
3005:
2180:
171:
2731:
2660:
2655:
2543:
2200:
2075:
2044:
2008:
1975:
1943:
1908:
1875:
1846:
1815:
1780:
1737:
1702:
1666:
1625:
1593:
1550:
1517:
1475:
1467:
1426:
1418:
1377:
1369:
1311:
1142:
1126:
1122:
420:
351:
295:
250:
2639:
3109:
3086:
2631:
2548:
2311:
1114:
395:
30:
2970:
2960:
2887:
2504:
2494:
2418:
2250:
1691:"TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator"
1480:
1455:
1431:
1406:
1382:
1357:
1707:
1690:
1521:
727:
722:
717:
712:
707:
702:
697:
681:
676:
671:
666:
661:
656:
651:
635:
630:
625:
620:
3247:
2538:
2321:
2240:
1979:
1932:"Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease"
1373:
607:
1759:
1572:
155:
3200:
3144:
3124:
3043:
3033:
2975:
2922:
2852:
2751:
2695:
2382:
2372:
2362:
2265:
2245:
2210:
2205:
1653:
Yu J, Tian S, Metheny-Barlow L, Chew LJ, Hayes AJ, Pan H, Yu GL, Li LY (Dec 2001).
1645:
1182:
413:
192:
1913:
1896:
2049:
2032:
179:
3154:
3149:
3053:
3038:
3010:
3000:
2995:
2950:
2917:
2912:
2907:
2902:
2897:
2882:
2877:
2700:
2685:
2680:
2499:
2484:
2301:
2013:
1996:
1820:
1803:
1285:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1267:
National Center for
Biotechnology Information, U.S. National Library of Medicine
703:
activation of cysteine-type endopeptidase activity involved in apoptotic process
2098:
2079:
1879:
1850:
1726:"A novel secreted splice variant of vascular endothelial cell growth inhibitor"
496:
2990:
2892:
2746:
2291:
1158:
312:
209:
159:
1165:(death receptor 3) and TNFRSF6B (decoy receptor 3). It can activate both the
1121:(ligand) superfamily, where it is member 15. It is the sole known ligand for
3164:
3159:
2940:
2387:
1995:
Prehn JL, Thomas LS, Landers CJ, Yu QT, Michelsen KS, Targan SR (Apr 2007).
1724:
Chew LJ, Pan H, Yu J, Tian S, Huang WQ, Zhang JY, Pang S, Li LY (May 2002).
1555:
1538:
1471:
1343:"Entrez Gene: TNFSF15 tumor necrosis factor (ligand) superfamily, member 15"
1178:
1174:
1154:
757:
556:
434:
379:
366:
278:
265:
167:
2087:
2058:
2022:
1987:
1957:
1922:
1887:
1858:
1829:
1794:
1785:
1768:
1751:
1716:
1680:
1637:
1629:
1598:
1581:
1489:
1440:
1391:
1325:
1742:
1725:
1671:
1654:
1607:
1564:
1529:
1067:
1062:
2392:
1948:
1931:
1166:
1162:
1051:
902:
883:
1454:
Kakuta Y, Kinouchi Y, Negoro K, Takahashi S, Shimosegawa T (Oct 2006).
1405:
Picornell Y, Mei L, Taylor K, Yang H, Targan SR, Rotter JI (Nov 2007).
1316:
1299:
1103:
869:
824:
1422:
100:
96:
92:
88:
84:
80:
76:
2965:
2955:
2600:
2596:
2592:
2588:
2584:
2580:
1150:
1146:
1035:
779:
3188:
1137:
The protein encoded by this gene is a cytokine that belongs to the
2635:
2576:
2572:
2568:
2564:
2560:
2556:
2453:
742:
738:
3196:
3020:
2932:
2869:
1170:
1110:
147:
2102:
587:
1141:(TNF) ligand family. This protein is abundantly expressed in
403:
3208:
2261:
Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
568:
3099:
3077:
3019:
2931:
2868:
2851:
2844:
2824:
2804:
2784:
2760:
2719:
2526:
2517:
2472:
2452:
2401:
2335:
2279:
2168:
2159:
2139:
2068:
996:
971:
945:
920:
1895:Hou W, Medynski D, Wu S, Lin X, Li LY (Aug 2005).
1241:
1239:
1237:
1220:
1218:
1216:
1153:. The expression of this protein is inducible by
350:
249:
2353:Granulocyte macrophage colony-stimulating factor
708:activation of NF-kappaB-inducing kinase activity
698:tumor necrosis factor-mediated signaling pathway
1200:have been found to be strongly associated with
18:Protein-coding gene in the species Homo sapiens
1300:"A gene network for navigating the literature"
1246:GRCm38: Ensembl release 89: ENSMUSG00000050395
3228:
2114:
8:
1225:GRCh38: Ensembl release 89: ENSG00000181634
3235:
3221:
3120:Leukemia/leukocyte inhibitory factor (LIF)
2865:
2848:
2523:
2165:
2121:
2107:
2099:
1767:Wen L, Zhuang L, Luo X, Wei P (Oct 2003).
753:
603:
391:
290:
187:
65:
3115:FMS-like tyrosine kinase 3 ligand (FLT3L)
2544:Interferon alpha (interferon alfa, IFN-α)
2048:
2012:
1947:
1912:
1819:
1784:
1741:
1706:
1670:
1597:
1554:
1479:
1430:
1381:
1315:
1161:. This cytokine is a ligand for receptor
728:regulation of signaling receptor activity
3137:Additional cytokine receptor modulators:
1407:"TNFSF15 is an ethnic-specific IBD gene"
1337:
1335:
1212:
2961:Cucurbitacin I (elatericin B, JSI-124)
1358:"On death receptor 3 and its ligands…"
621:tumor necrosis factor receptor binding
20:
2297:Granulocyte colony-stimulating factor
1080:Vascular endothelial growth inhibitor
667:integral component of plasma membrane
355:
316:
311:
254:
213:
208:
7:
3185:
3183:
2656:Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
2429:Macrophage colony-stimulating factor
1968:Acta Biochimica et Biophysica Sinica
1173:signalling pathways, and acts as an
3130:Thymic stromal lymphopoietin (TSLP)
1773:The Journal of Biological Chemistry
1586:The Journal of Biological Chemistry
1298:Hoffmann R, Valencia A (Jul 2004).
1125:, and it can also be recognized by
3207:. You can help Knowledge (XXG) by
993:
968:
942:
917:
893:
874:
848:
829:
803:
784:
677:intracellular anatomical structure
573:
491:
429:
408:
14:
1145:, but is not expressed in either
1106:that in humans is encoded by the
3187:
1980:10.1111/j.1745-7270.2006.00155.x
1374:10.1111/j.1365-2567.2012.03606.x
577:
339:
332:
326:
303:
238:
231:
225:
200:
29:
2661:Interferon omega (IFN-ω, IFNW1)
652:integral component of membrane
588:More reference expression data
557:More reference expression data
1:
3264:Human chromosome 9 gene stubs
1914:10.1158/1078-0432.CCR-05-0384
1708:10.1016/S1074-7613(02)00283-2
1522:10.1016/s0378-1119(97)00509-x
324:
223:
2050:10.4049/jimmunol.178.11.7325
3254:Genes on human chromosome 9
2505:Thrombopoietin (THPO, MGDF)
2271:Pegol sihematide (EPO-018B)
2191:Carbamylated erythropoietin
2014:10.4049/jimmunol.178.7.4033
1821:10.4049/jimmunol.171.9.4868
1411:Inflammatory Bowel Diseases
3280:
3182:
2080:10.1016/j.bbrc.2007.09.097
1880:10.1016/j.cyto.2004.12.001
1851:10.1016/j.clim.2004.02.007
1202:inflammatory bowel disease
631:signaling receptor binding
3054:Tofacitinib (tasocitinib)
3011:Tofacitinib (tasocitinib)
2918:Tofacitinib (tasocitinib)
1281:"Mouse PubMed Reference:"
1263:"Human PubMed Reference:"
1096:TNF superfamily member 15
1066:
1061:
1057:
1050:
1034:
1021:Chr 9: 114.78 – 114.81 Mb
1015:
1000:
975:
964:
949:
924:
913:
900:
896:
881:
877:
868:
855:
851:
836:
832:
823:
810:
806:
791:
787:
778:
763:
756:
752:
736:
606:
602:
585:
576:
567:
554:
503:
494:
441:
432:
402:
394:
390:
373:
360:
323:
302:
293:
289:
272:
259:
222:
199:
190:
186:
141:
138:
128:
121:
116:
73:
68:
51:
46:
41:
37:
28:
23:
2732:Interferon gamma (IFN-γ)
1936:Human Molecular Genetics
1901:Clinical Cancer Research
2632:Interferon beta (IFN-β)
1556:10.1096/fasebj.13.1.181
1472:10.1136/gut.2006.100297
1117:protein. It belongs to
1028:Chr 4: 63.64 – 63.66 Mb
3110:Cardiotrophin 1 (CT-1)
1786:10.1074/jbc.M305833200
1630:10.1038/sj.onc.1203059
1599:10.1074/jbc.274.3.1479
469:pancreatic ductal cell
3107:Additional cytokines:
3034:Decernotinib (VX-509)
2671:Peginterferon alfa-2b
2666:Peginterferon alfa-2a
2186:Asialo erythropoietin
2037:Journal of Immunology
2001:Journal of Immunology
1808:Journal of Immunology
1743:10.1096/fj.01-0757fje
1672:10.1161/hh2401.101909
1139:tumor necrosis factor
1119:tumor necrosis factor
465:palpebral conjunctiva
2622:Interferon alfacon-1
2251:Erythropoietin (EPO)
1659:Circulation Research
1356:Wang EC (Sep 2012).
657:extracellular region
318:Chromosome 4 (mouse)
216:Chromosome 9 (human)
69:List of PDB id codes
42:Available structures
2769:See IL-28R (IFNLR)
2737:Interferon gamma 1b
2627:Interferon alpha-n3
1839:Clinical Immunology
723:signal transduction
682:extracellular space
457:germinal epithelium
180:TNFSF15 - orthologs
3195:This article on a
3125:Oncostatin M (OSM)
2651:Interferon beta 1b
2646:Interferon beta 1a
2617:Interferon alfa n1
2612:Interferon alfa 2b
2607:Interferon alfa 2a
2441:Kinase inhibitors:
1949:10.1093/hmg/ddi379
1317:10.1038/ng0704-664
1189:Clinical relevance
1088:TNF-like ligand 1A
858:ENSMUSG00000050395
691:Biological process
645:Cellular component
614:Molecular function
3216:
3215:
3177:
3176:
3173:
3172:
3095:
3094:
2862:
2780:
2779:
2513:
2512:
2256:Erythropoietin-Fc
2130:Cytokine receptor
1423:10.1002/ibd.20223
1177:factor to induce
1143:endothelial cells
1086:), also known as
1077:
1076:
1073:
1072:
1046:
1045:
1011:
1010:
990:
989:
960:
959:
939:
938:
909:
908:
890:
889:
864:
863:
845:
844:
819:
818:
800:
799:
748:
747:
718:apoptotic process
626:cytokine activity
598:
597:
594:
593:
563:
562:
550:
549:
488:
487:
386:
385:
285:
284:
112:
111:
108:
107:
52:Ortholog search:
3271:
3237:
3230:
3223:
3191:
3184:
2866:
2856:
2849:
2708:Decoy receptors:
2524:
2201:Darbepoetin alfa
2166:
2123:
2116:
2109:
2100:
2091:
2062:
2052:
2026:
2016:
1991:
1961:
1951:
1942:(22): 3499–506.
1926:
1916:
1907:(15): 5595–602.
1891:
1862:
1833:
1823:
1798:
1788:
1763:
1745:
1720:
1710:
1684:
1674:
1649:
1624:(47): 6496–504.
1611:
1601:
1576:
1558:
1533:
1494:
1493:
1483:
1451:
1445:
1444:
1434:
1402:
1396:
1395:
1385:
1353:
1347:
1346:
1339:
1330:
1329:
1319:
1295:
1289:
1288:
1277:
1271:
1270:
1259:
1253:
1243:
1232:
1222:
1127:decoy receptor 3
1123:death receptor 3
1059:
1058:
1030:
1023:
1006:
994:
985:
969:
965:RefSeq (protein)
955:
943:
934:
918:
894:
875:
849:
830:
804:
785:
754:
604:
590:
581:
574:
559:
499:
497:Top expressed in
492:
445:cartilage tissue
437:
435:Top expressed in
430:
409:
392:
382:
369:
358:
343:
336:
330:
319:
307:
291:
281:
268:
257:
242:
235:
229:
218:
204:
188:
182:
133:
126:
103:
66:
60:
39:
38:
33:
21:
3279:
3278:
3274:
3273:
3272:
3270:
3269:
3268:
3244:
3243:
3242:
3241:
3180:
3178:
3169:
3091:
3087:Deucravacitinib
3073:
3015:
2927:
2855:
2840:
2820:
2800:
2776:
2756:
2715:
2549:Interferon alfa
2509:
2468:
2448:
2397:
2331:
2327:Pegnartograstim
2312:Lipegfilgrastim
2275:
2221:Epoetin epsilon
2155:
2135:
2127:
2096:
2094:
2065:
2043:(11): 7325–33.
2029:
1994:
1964:
1929:
1894:
1865:
1836:
1801:
1779:(40): 39251–8.
1766:
1723:
1687:
1652:
1614:
1579:
1536:
1506:
1502:
1500:Further reading
1497:
1453:
1452:
1448:
1404:
1403:
1399:
1355:
1354:
1350:
1341:
1340:
1333:
1304:Nature Genetics
1297:
1296:
1292:
1279:
1278:
1274:
1261:
1260:
1256:
1244:
1235:
1223:
1214:
1210:
1191:
1135:
1115:anti-angiogenic
1068:View/Edit Mouse
1063:View/Edit Human
1026:
1019:
1016:Location (UCSC)
1002:
981:
977:
951:
930:
926:
839:ENSG00000181634
732:
713:immune response
686:
662:plasma membrane
640:
636:protein binding
586:
555:
546:
541:
537:
533:
529:
525:
521:
517:
513:
509:
495:
484:
481:mucosa of ileum
479:
475:
471:
467:
463:
461:visceral pleura
459:
455:
451:
447:
433:
377:
364:
356:
346:
345:
344:
337:
317:
294:Gene location (
276:
263:
255:
245:
244:
243:
236:
214:
191:Gene location (
142:
129:
122:
75:
53:
19:
12:
11:
5:
3277:
3275:
3267:
3266:
3261:
3256:
3246:
3245:
3240:
3239:
3232:
3225:
3217:
3214:
3213:
3192:
3175:
3174:
3171:
3170:
3168:
3167:
3162:
3157:
3152:
3147:
3142:
3133:
3132:
3127:
3122:
3117:
3112:
3103:
3101:
3097:
3096:
3093:
3092:
3090:
3089:
3083:
3081:
3075:
3074:
3072:
3071:
3066:
3061:
3056:
3051:
3046:
3041:
3036:
3031:
3029:Cercosporamide
3025:
3023:
3017:
3016:
3014:
3013:
3008:
3003:
2998:
2993:
2988:
2983:
2978:
2973:
2971:Deuruxolitinib
2968:
2963:
2958:
2953:
2948:
2943:
2937:
2935:
2929:
2928:
2926:
2925:
2920:
2915:
2910:
2905:
2900:
2895:
2890:
2888:Deuruxolitinib
2885:
2880:
2874:
2872:
2863:
2846:
2842:
2841:
2839:
2838:
2830:
2828:
2822:
2821:
2819:
2818:
2810:
2808:
2802:
2801:
2799:
2798:
2790:
2788:
2782:
2781:
2778:
2777:
2775:
2774:
2766:
2764:
2762:IFNLR (λ, III)
2758:
2757:
2755:
2754:
2749:
2740:
2739:
2734:
2725:
2723:
2717:
2716:
2714:
2713:
2704:
2703:
2698:
2693:
2688:
2683:
2674:
2673:
2668:
2663:
2658:
2653:
2648:
2643:
2629:
2624:
2619:
2614:
2609:
2604:
2546:
2541:
2532:
2530:
2528:IFNAR (α/β, I)
2521:
2515:
2514:
2511:
2510:
2508:
2507:
2502:
2497:
2495:Promegapoietin
2492:
2487:
2478:
2476:
2474:Thrombopoietin
2470:
2469:
2467:
2466:
2458:
2456:
2450:
2449:
2447:
2446:
2437:
2436:
2431:
2426:
2421:
2419:Interleukin-34
2416:
2407:
2405:
2399:
2398:
2396:
2395:
2390:
2385:
2376:
2375:
2370:
2365:
2360:
2355:
2350:
2341:
2339:
2333:
2332:
2330:
2329:
2324:
2319:
2314:
2309:
2304:
2299:
2294:
2285:
2283:
2277:
2276:
2274:
2273:
2268:
2263:
2258:
2253:
2248:
2243:
2238:
2233:
2228:
2223:
2218:
2213:
2208:
2203:
2198:
2193:
2188:
2183:
2174:
2172:
2170:Erythropoietin
2163:
2157:
2156:
2154:
2153:
2145:
2143:
2137:
2136:
2128:
2126:
2125:
2118:
2111:
2103:
2093:
2092:
2063:
2027:
1992:
1962:
1927:
1892:
1863:
1834:
1814:(9): 4868–74.
1799:
1764:
1721:
1685:
1665:(12): 1161–7.
1650:
1612:
1592:(3): 1479–86.
1577:
1534:
1516:(1–2): 35–46.
1503:
1501:
1498:
1496:
1495:
1466:(10): 1527–8.
1446:
1417:(11): 1333–8.
1397:
1368:(1): 114–116.
1348:
1331:
1290:
1272:
1254:
1233:
1211:
1209:
1206:
1190:
1187:
1134:
1131:
1075:
1074:
1071:
1070:
1065:
1055:
1054:
1048:
1047:
1044:
1043:
1041:
1039:
1032:
1031:
1024:
1017:
1013:
1012:
1009:
1008:
998:
997:
991:
988:
987:
973:
972:
966:
962:
961:
958:
957:
947:
946:
940:
937:
936:
922:
921:
915:
911:
910:
907:
906:
898:
897:
891:
888:
887:
879:
878:
872:
866:
865:
862:
861:
853:
852:
846:
843:
842:
834:
833:
827:
821:
820:
817:
816:
808:
807:
801:
798:
797:
789:
788:
782:
776:
775:
770:
765:
761:
760:
750:
749:
746:
745:
734:
733:
731:
730:
725:
720:
715:
710:
705:
700:
694:
692:
688:
687:
685:
684:
679:
674:
669:
664:
659:
654:
648:
646:
642:
641:
639:
638:
633:
628:
623:
617:
615:
611:
610:
600:
599:
596:
595:
592:
591:
583:
582:
571:
565:
564:
561:
560:
552:
551:
548:
547:
545:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
501:
500:
489:
486:
485:
483:
482:
478:
474:
470:
466:
462:
458:
454:
450:
449:jejunal mucosa
446:
442:
439:
438:
426:
425:
417:
406:
400:
399:
396:RNA expression
388:
387:
384:
383:
375:
371:
370:
362:
359:
354:
348:
347:
338:
331:
325:
321:
320:
315:
309:
308:
300:
299:
287:
286:
283:
282:
274:
270:
269:
261:
258:
253:
247:
246:
237:
230:
224:
220:
219:
212:
206:
205:
197:
196:
184:
183:
140:
136:
135:
127:
119:
118:
114:
113:
110:
109:
106:
105:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
3276:
3265:
3262:
3260:
3257:
3255:
3252:
3251:
3249:
3238:
3233:
3231:
3226:
3224:
3219:
3218:
3212:
3210:
3206:
3202:
3198:
3193:
3190:
3186:
3181:
3166:
3163:
3161:
3158:
3156:
3153:
3151:
3148:
3146:
3143:
3141:
3138:
3135:
3134:
3131:
3128:
3126:
3123:
3121:
3118:
3116:
3113:
3111:
3108:
3105:
3104:
3102:
3098:
3088:
3085:
3084:
3082:
3080:
3076:
3070:
3067:
3065:
3062:
3060:
3057:
3055:
3052:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3030:
3027:
3026:
3024:
3022:
3018:
3012:
3009:
3007:
3004:
3002:
2999:
2997:
2994:
2992:
2989:
2987:
2984:
2982:
2979:
2977:
2974:
2972:
2969:
2967:
2964:
2962:
2959:
2957:
2954:
2952:
2949:
2947:
2944:
2942:
2939:
2938:
2936:
2934:
2930:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2906:
2904:
2901:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2881:
2879:
2876:
2875:
2873:
2871:
2867:
2864:
2860:
2854:
2850:
2847:
2843:
2836:
2832:
2831:
2829:
2827:
2823:
2816:
2812:
2811:
2809:
2807:
2803:
2796:
2792:
2791:
2789:
2787:
2783:
2772:
2768:
2767:
2765:
2763:
2759:
2753:
2750:
2748:
2745:
2742:
2741:
2738:
2735:
2733:
2730:
2727:
2726:
2724:
2722:
2721:IFNGR (γ, II)
2718:
2712:
2709:
2706:
2705:
2702:
2699:
2697:
2694:
2692:
2689:
2687:
2684:
2682:
2679:
2676:
2675:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2641:
2637:
2633:
2630:
2628:
2625:
2623:
2620:
2618:
2615:
2613:
2610:
2608:
2605:
2602:
2598:
2594:
2590:
2586:
2582:
2578:
2574:
2570:
2566:
2562:
2558:
2554:
2550:
2547:
2545:
2542:
2540:
2539:Albinterferon
2537:
2534:
2533:
2531:
2529:
2525:
2522:
2520:
2516:
2506:
2503:
2501:
2498:
2496:
2493:
2491:
2488:
2486:
2483:
2480:
2479:
2477:
2475:
2471:
2464:
2460:
2459:
2457:
2455:
2451:
2445:
2442:
2439:
2438:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2415:
2412:
2409:
2408:
2406:
2404:
2400:
2394:
2391:
2389:
2386:
2384:
2381:
2378:
2377:
2374:
2371:
2369:
2366:
2364:
2361:
2359:
2356:
2354:
2351:
2349:
2346:
2343:
2342:
2340:
2338:
2337:GM-CSF (CSF2)
2334:
2328:
2325:
2323:
2322:Pegfilgrastim
2320:
2318:
2315:
2313:
2310:
2308:
2305:
2303:
2300:
2298:
2295:
2293:
2290:
2287:
2286:
2284:
2282:
2278:
2272:
2269:
2267:
2264:
2262:
2259:
2257:
2254:
2252:
2249:
2247:
2244:
2242:
2241:Epoetin theta
2239:
2237:
2236:Epoetin omega
2234:
2232:
2231:Epoetin kappa
2229:
2227:
2226:Epoetin gamma
2224:
2222:
2219:
2217:
2216:Epoetin delta
2214:
2212:
2209:
2207:
2204:
2202:
2199:
2197:
2194:
2192:
2189:
2187:
2184:
2182:
2179:
2176:
2175:
2173:
2171:
2167:
2164:
2162:
2158:
2151:
2147:
2146:
2144:
2142:
2138:
2134:
2131:
2124:
2119:
2117:
2112:
2110:
2105:
2104:
2101:
2097:
2089:
2085:
2081:
2077:
2073:
2069:
2064:
2060:
2056:
2051:
2046:
2042:
2038:
2034:
2028:
2024:
2020:
2015:
2010:
2007:(7): 4033–8.
2006:
2002:
1998:
1993:
1989:
1985:
1981:
1977:
1974:(4): 249–53.
1973:
1969:
1963:
1959:
1955:
1950:
1945:
1941:
1937:
1933:
1928:
1924:
1920:
1915:
1910:
1906:
1902:
1898:
1893:
1889:
1885:
1881:
1877:
1874:(5): 229–35.
1873:
1869:
1864:
1860:
1856:
1852:
1848:
1844:
1840:
1835:
1831:
1827:
1822:
1817:
1813:
1809:
1805:
1800:
1796:
1792:
1787:
1782:
1778:
1774:
1770:
1765:
1761:
1757:
1753:
1749:
1744:
1739:
1735:
1731:
1730:FASEB Journal
1727:
1722:
1718:
1714:
1709:
1704:
1701:(3): 479–92.
1700:
1696:
1692:
1686:
1682:
1678:
1673:
1668:
1664:
1660:
1656:
1651:
1647:
1643:
1639:
1635:
1631:
1627:
1623:
1619:
1613:
1609:
1605:
1600:
1595:
1591:
1587:
1583:
1578:
1574:
1570:
1566:
1562:
1557:
1552:
1548:
1544:
1543:FASEB Journal
1540:
1535:
1531:
1527:
1523:
1519:
1515:
1511:
1505:
1504:
1499:
1491:
1487:
1482:
1477:
1473:
1469:
1465:
1461:
1457:
1450:
1447:
1442:
1438:
1433:
1428:
1424:
1420:
1416:
1412:
1408:
1401:
1398:
1393:
1389:
1384:
1379:
1375:
1371:
1367:
1363:
1359:
1352:
1349:
1344:
1338:
1336:
1332:
1327:
1323:
1318:
1313:
1309:
1305:
1301:
1294:
1291:
1286:
1282:
1276:
1273:
1268:
1264:
1258:
1255:
1251:
1247:
1242:
1240:
1238:
1234:
1230:
1226:
1221:
1219:
1217:
1213:
1207:
1205:
1203:
1199:
1196:
1188:
1186:
1184:
1180:
1176:
1172:
1168:
1164:
1160:
1156:
1152:
1148:
1144:
1140:
1132:
1130:
1128:
1124:
1120:
1116:
1113:. VEGI is an
1112:
1109:
1105:
1101:
1097:
1093:
1089:
1085:
1081:
1069:
1064:
1060:
1056:
1053:
1049:
1042:
1040:
1037:
1033:
1029:
1025:
1022:
1018:
1014:
1007:
1005:
999:
995:
992:
986:
984:
980:
974:
970:
967:
963:
956:
954:
948:
944:
941:
935:
933:
929:
923:
919:
916:
914:RefSeq (mRNA)
912:
905:
904:
899:
895:
892:
886:
885:
880:
876:
873:
871:
867:
860:
859:
854:
850:
847:
841:
840:
835:
831:
828:
826:
822:
815:
814:
809:
805:
802:
796:
795:
790:
786:
783:
781:
777:
774:
771:
769:
766:
762:
759:
755:
751:
744:
740:
735:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
695:
693:
690:
689:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
649:
647:
644:
643:
637:
634:
632:
629:
627:
624:
622:
619:
618:
616:
613:
612:
609:
608:Gene ontology
605:
601:
589:
584:
580:
575:
572:
570:
566:
558:
553:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
505:
502:
498:
493:
490:
480:
476:
473:parotid gland
472:
468:
464:
460:
456:
452:
448:
444:
443:
440:
436:
431:
428:
427:
424:
422:
418:
416:
415:
411:
410:
407:
405:
401:
397:
393:
389:
381:
376:
372:
368:
363:
353:
349:
342:
335:
329:
322:
314:
310:
306:
301:
297:
292:
288:
280:
275:
271:
267:
262:
252:
248:
241:
234:
228:
221:
217:
211:
207:
203:
198:
194:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
137:
132:
125:
120:
115:
104:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
3209:expanding it
3201:chromosome 9
3194:
3179:
3145:Lestaurtinib
3136:
3106:
3044:Ritlecitinib
2976:Lestaurtinib
2923:Upadacitinib
2752:Fontolizumab
2743:
2728:
2707:
2696:Rontalizumab
2677:
2535:
2490:Pegacaristim
2481:
2440:
2410:
2403:M-CSF (CSF1)
2383:Mavrilimumab
2379:
2373:Sargramostim
2363:Molgramostim
2348:Ecogramostim
2344:
2317:Nartograstim
2288:
2281:G-CSF (CSF3)
2266:Peginesatide
2246:Epoetin zeta
2211:Epoetin beta
2206:Epoetin alfa
2177:
2095:
2071:
2067:
2040:
2036:
2004:
2000:
1971:
1967:
1939:
1935:
1904:
1900:
1871:
1867:
1845:(1): 66–77.
1842:
1838:
1811:
1807:
1776:
1772:
1736:(7): 742–4.
1733:
1729:
1698:
1694:
1662:
1658:
1621:
1617:
1589:
1585:
1549:(1): 181–9.
1546:
1542:
1513:
1509:
1463:
1459:
1449:
1414:
1410:
1400:
1365:
1361:
1351:
1307:
1303:
1293:
1284:
1275:
1266:
1257:
1194:
1192:
1183:angiogenesis
1136:
1107:
1099:
1095:
1091:
1087:
1083:
1079:
1078:
1001:
979:NP_001191273
976:
950:
932:NM_001204344
925:
901:
882:
856:
837:
811:
792:
772:
767:
543:zone of skin
531:renal cortex
519:human kidney
511:right kidney
419:
412:
277:114,806,039
264:114,784,652
139:External IDs
74:
15:
3155:Quizartinib
3150:Midostaurin
3039:Peficitinib
3001:Ruxolitinib
2996:Peficitinib
2951:Baricitinib
2913:Ruxolitinib
2908:Peficitinib
2903:Oclacitinib
2898:Momelotinib
2883:Baricitinib
2878:Abrocitinib
2786:Interleukin
2744:Antibodies:
2701:Sifalimumab
2686:Faralimomab
2681:Anifrolumab
2678:Antibodies:
2500:Romiplostim
2485:Eltrombopag
2454:SCF (c-Kit)
2380:Antibodies:
2368:Regramostim
2302:Lenograstim
378:63,663,350
365:63,642,840
357:4|4 C1
117:Identifiers
3248:Categories
3140:Emfilermin
2991:Pacritinib
2893:Filgotinib
2859:inhibitors
2747:Emapalumab
2519:Interferon
2444:Agerafenib
2434:Mirimostim
2424:Lanimostim
2358:Milodistim
2307:Leridistim
2292:Filgrastim
2133:modulators
2074:(1): 1–6.
1362:Immunology
1310:(7): 664.
1252:, May 2017
1231:, May 2017
1208:References
1159:IL-1 alpha
423:(ortholog)
160:HomoloGene
3259:Cytokines
3199:on human
3165:Sunitinib
3160:Sorafenib
3069:ZM-449829
3059:WHI-P 154
3049:TCS-21311
2986:NSC-33994
2941:Atiprimod
2729:Agonists:
2711:Bifarcept
2536:Agonists:
2482:Agonists:
2414:Cilmostim
2411:Agonists:
2388:Namilumab
2345:Agonists:
2289:Agonists:
2178:Agonists:
2141:Chemokine
1179:apoptosis
1175:autocrine
1155:TNF-alpha
1004:NP_796345
983:NP_005109
953:NM_177371
928:NM_005118
758:Orthologs
168:GeneCards
3064:ZM-39923
2981:NSC-7908
2946:AZD-1480
2837:instead.
2817:instead.
2797:instead.
2773:instead.
2691:MEDI-545
2465:instead.
2393:Otilimab
2196:CNTO-530
2152:instead.
2088:17935696
2059:17513783
2023:17371957
1988:16604264
1958:16221758
1923:16061878
1888:15760679
1868:Cytokine
1859:15207783
1830:14568967
1795:12882979
1760:34749634
1752:11923219
1717:11911831
1695:Immunity
1681:11739281
1638:10597252
1618:Oncogene
1573:26066673
1490:16966713
1441:17663424
1392:22612445
1326:15226743
1248:–
1227:–
1193:Several
1163:TNFRSF25
1133:Function
1052:Wikidata
737:Sources:
672:membrane
523:duodenum
453:duodenum
3006:SD-1008
2181:ARA-290
1646:7013492
1608:9880523
1565:9872942
1530:9434163
1481:1856432
1432:2552994
1383:3449252
1250:Ensembl
1229:Ensembl
1195:TNFSF15
1151:T cells
1108:TNFSF15
1104:protein
1100:TNFSF15
870:UniProt
825:Ensembl
764:Species
743:QuickGO
535:jejunum
477:urethra
398:pattern
172:TNFSF15
156:2180140
131:TNFSF15
124:Aliases
24:TNFSF15
3100:Others
2966:CYT387
2956:CHZ868
2845:Others
2601:IFNA21
2597:IFNA17
2593:IFNA16
2589:IFNA14
2585:IFNA13
2581:IFNA10
2086:
2057:
2021:
1986:
1956:
1921:
1886:
1857:
1828:
1793:
1758:
1750:
1715:
1679:
1644:
1636:
1606:
1571:
1563:
1528:
1488:
1478:
1439:
1429:
1390:
1380:
1324:
1102:), is
1094:) and
1038:search
1036:PubMed
903:Q5UBV8
884:O95150
813:326623
780:Entrez
569:BioGPS
507:embryo
148:604052
3203:is a
2640:IFNB3
2636:IFNB1
2577:IFNA8
2573:IFNA7
2569:IFNA6
2565:IFNA5
2561:IFNA4
2557:IFNA2
2553:IFNA1
1756:S2CID
1642:S2CID
1569:S2CID
1167:NF-κB
773:Mouse
768:Human
739:Amigo
539:colon
527:ileum
421:Mouse
414:Human
361:Start
296:Mouse
260:Start
193:Human
3205:stub
3197:gene
3079:TYK2
3021:JAK3
2933:JAK2
2870:JAK1
2835:here
2833:See
2815:here
2813:See
2806:TGFβ
2795:here
2793:See
2771:here
2463:here
2461:See
2150:here
2148:See
2084:PMID
2055:PMID
2019:PMID
1984:PMID
1954:PMID
1919:PMID
1884:PMID
1855:PMID
1826:PMID
1791:PMID
1748:PMID
1713:PMID
1677:PMID
1634:PMID
1604:PMID
1561:PMID
1526:PMID
1510:Gene
1486:PMID
1437:PMID
1388:PMID
1322:PMID
1198:SNPs
1171:MAPK
1169:and
1157:and
1111:gene
1092:TL1A
1084:VEGI
794:9966
515:lung
404:Bgee
352:Band
313:Chr.
256:9q32
251:Band
210:Chr.
164:3755
144:OMIM
101:3MI8
97:3K51
93:2RJL
89:2RJK
85:2RE9
81:2QE3
77:2O0O
58:RCSB
55:PDBe
2853:JAK
2826:TNF
2161:CSF
2076:doi
2072:364
2045:doi
2041:178
2009:doi
2005:178
1976:doi
1944:doi
1909:doi
1876:doi
1847:doi
1843:112
1816:doi
1812:171
1781:doi
1777:278
1738:doi
1703:doi
1667:doi
1626:doi
1594:doi
1590:274
1551:doi
1518:doi
1514:204
1476:PMC
1468:doi
1460:Gut
1427:PMC
1419:doi
1378:PMC
1370:doi
1366:137
1312:doi
1149:or
374:End
273:End
176:OMA
152:MGI
48:PDB
3250::
2638:,
2599:,
2595:,
2591:,
2587:,
2583:,
2579:,
2575:,
2571:,
2567:,
2563:,
2559:,
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2003:.
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1982:.
1972:38
1970:.
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1940:14
1938:.
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1917:.
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166:;
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158:;
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