410:(RI-MUHC), one of Canada's largest research centers. At the RI-MUHC he was a professor in the faculty of medicine at McGill University and held a Canada Research Chair in Biochemical Pharmacology and the Phil Gold Chair in Medicine at McGill and the MUHC. Under Papadopoulos' tenure, more than $ 300 million federal and provincial grants were raised, resulting in the creating of a state-of-the-art clinical and biomedical research facility.
31:
318:) in the mitochondria. This focus on steroidogenesis revealed the mitochondrial protein complex that drives cholesterol import, trafficking, and metabolism for steroid hormone production. The identification of the protein complex has led to molecular strategies to which increase steroid hormone formation.
413:
Since 2016, Papadopoulos has served as dean of the Alfred E. Mann School of
Pharmacy and Pharmaceutical Sciences at University of Southern California, previously known as USC School of Pharmacy. In 2022, USC announced the $ 50 million renaming gift for the endowment of the USC Alfred E. Mann School
267:
where he continued research on the regulation of steroidogenesis to identify the mechanisms of action of DBI on mitochondrial steroid formation in steroidogenic cells. Later, Papadopoulos worked in collaboration with
Patrizia Guarneri demonstrating that brain neurosteroid synthesis is under the
297:
Papadopoulos' studies demonstrated that the development of Leydig cells and their ability to produce testosterone are controlled by intratesticular factors, and that TSPO is a high-affinity cholesterol and drug-binding protein which controls the rate of steroid formation in rodents and humans.
247:
mechanisms responsible for the initiation and maintenance of steroid hormones in health and disease. He also examines the regulation of steroid biosynthesis, intracellular compartmentalization and homeostasis by hormones, chemicals, drugs, natural products and environmental factors. Additional
1776:
Rupprecht, Rainer; Papadopoulos, Vassilios; Rammes, Gerhard; Baghai, Thomas C.; Fan, Jinjiang; Akula, Nagaraju; Groyer, Ghislaine; Adams, David; Schumacher, Michael (December 2010). "Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders".
272:(TSPO) drug ligands and endogenous DBI, leading to the first pharmacological means to regulate steroid formation in the brain. His research on steroidogenesis continued at McGill, focusing on the mechanisms of mitochondrial cholesterol import and the synthesis of steroids and
401:
Between 2004 and 2007, Papadopoulos was the
Associate Vice President for Research at Georgetown University Medical Center, and subsequently appointed the Director of Biomedical Graduate Research Organization. Under Papadopoulos' direction, the institution obtained an
1493:
Li, Yuchang; Chen, Liting; Li, Lu; Sottas, Chantal; Petrillo, Stephanie K.; Lazaris, Anthoula; Metrakos, Peter; Wu, Hangyu; Ishida, Yuji; Saito, Takeshi; Golden-Mason, Lucy; Rosen, Hugo R.; Wolff, Jeremy J.; Silvescu, Cristina I.; Garza, Samuel (May 2021).
1036:
Li, Yuchang; Chen, Liting; Li, Lu; Sottas, Chantal; Petrillo, Stephanie K.; Lazaris, Anthoula; Metrakos, Peter; Wu, Hangyu; Ishida, Yuji; Saito, Takeshi; Golden-Mason, Lucy; Rosen, Hugo R.; Wolff, Jeremy J.; Silvescu, Cristina I.; Garza, Samuel (May 2021).
992:
Campioli, Enrico; Duong, Tam B.; Deschamps, François; Papadopoulos, Vassilios (July 2015). "Cyclohexane-1,2-dicarboxylic acid diisononyl ester and metabolite effects on rat epididymal stromal vascular fraction differentiation of adipose tissue".
1828:
Rammouz, Georges; Lecanu, Laurent; Aisen, Paul; Papadopoulos, Vassilios (2011-04-22). "A Lead Study on
Oxidative Stress-Mediated Dehydroepiandrosterone Formation in Serum: The Biochemical Basis for a Diagnosis of Alzheimer's Disease".
677:
Papadopoulos, Vassilios; Brown, A.Shane; Hall, Peter F. (May 1989). "Isolation and characterisation of calcineurin from adrenal cell cytoskeleton: identification of substrates for Ca2+-calmodulin-dependent phosphatase activity".
529:
Papadopoulos, V.; Carreau, S.; Szerman-Joly, E.; Drosdowsky, M.A.; Dehennin, L.; Scholler, R. (June 1986). "Rat testis 17β-estradiol: Identification by gas chromatography-mass spectrometry and age related cellular distribution".
1610:
Boujrad, Noureddine; Ogwuegbu, Stephen O.; Garnier, Martine; Lee, Choong-Hyun; Martin, Brian M.; Papadopoulos, Vassilios (1995-06-16). "Identification of a
Stimulator of Steroid Hormone Synthesis Isolated from Testis".
1926:
Culty, Martine; Thuillier, Raphael; Li, Wenping; Wang, Yan; Martinez-Arguelles, Daniel B.; Benjamin, Carolina
Gesteira; Triantafilou, Kostantinos M.; Zirkin, Barry R.; Papadopoulos, Vassilios (2008-06-01).
36:
576:
Papadopoulos, V.; Kamtchouing, P.; Drosdowsky, M. A.; de
Reviers, M. T. Hochereau; Carreau, S. (September 1987). "Adult rat Sertoli cells secrete a factor or factors which modulate Leydig cell function".
1375:
Sakai, Monica; Martinez-Arguelles, Daniel B.; Aprikian, Armen G.; Magliocco, Anthony M.; Papadopoulos, Vassilios (2016-02-04). "De novo steroid biosynthesis in human prostate cell lines and biopsies".
406:-funded General Clinical Research Center and its first Clinical and Translational Science Award. Papadopoulos served from 2007 to 2016 as the executive director and chief scientific officer of the
763:
Rone, Malena B.; Midzak, Andrew S.; Issop, Leeyah; Rammouz, Georges; Jagannathan, Sathvika; Fan, Jinjiang; Ye, Xiaoying; Blonder, Josip; Veenstra, Timothy; Papadopoulos, Vassilios (2012-11-01).
98:
Post-doctoral fellow, National Health and
Medical Research Council (NHMRC), Department of Endocrinology, The Prince of Wales Hospital, The University of New South Wales, Wales, Australia
232:. Papadopoulos has served on advisory committees as an industry leader and expert. He holds membership in the National Academies of Medicine and Pharmacy in France, is a fellow of the
1872:
Papadopoulos, V.; Lecanu, L. (2011-12-20). "Caprospinol: Discovery of a
Steroid Drug Candidate to Treat Alzheimer's Disease Based on 22R-Hydroxycholesterol Structure and Properties".
2139:
326:
Papadopoulos' neurosteroid research on inducing TSPO via drug ligands in glial cells increased neurosteroid formation and led to therapeutic application for the treatment of
233:
393:
formation in adult rats. This work contributed to the body of evidence on the endocrine disrupting potential of plasticizers and their regulation by governmental agencies.
2124:
386:
1567:
PAPADOPOULOS, VASSILIOS (June 1991). "Identification and
Purification of a Human Sertoli Cell- Secreted Protein (hSCSP-80)Stimulating Leydig Cell Steroid Biosynthesis".
95:
Postdoctoral fellow, Department of Biochemistry, Faculty of Medicine, C.N.R.S., (National Center of Scientific Research), Centre Hospitalier Universitaire, Caen, France
303:
146:
2114:
2079:
1426:
Li, Lu; Li, Yuchang; Sottas, Chantal; Culty, Martine; Fan, Jinjiang; Hu, Yiman; Cheung, Garett; Chemes, HĂ©ctor E.; Papadopoulos, Vassilios (2019-10-07).
1929:"In Utero Exposure to Di-(2-ethylhexyl) Phthalate Exerts Both Short-Term and Long-Lasting Suppressive Effects on Testosterone Production in the Rat1"
264:
1096:"Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells"
1718:"Induction of Androgen Formation in the Male by a TAT-VDAC1 Fusion Peptide Blocking 14-3-3É› Protein Adaptor and Mitochondrial VDAC1 Interactions"
315:
173:
237:
765:"Identification of a Dynamic Mitochondrial Protein Complex Driving Cholesterol Import, Trafficking, and Metabolism to Steroid Hormones"
2109:
1428:"Directing differentiation of human induced pluripotent stem cells toward androgen-producing Leydig cells rather than adrenal cells"
257:
201:
150:
122:
1194:"Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor"
2119:
1496:"Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease"
1039:"Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease"
407:
134:
129:, since 2016. Previously, he was the associate vice president and director of the Biomedical Graduate Research Organization at
828:"Proceedings of the International Congress on Hormonal Steroids and Hormones and Cancer. 21-25 October 2002, Fukuoka, Japan".
330:
and other mental health pathologies. Thereafter, TSPO drug ligands reached the market for the treatment of anxiety and other
403:
367:
205:
2041:
1716:
Aghazadeh, Yasaman; Martinez-Arguelles, Daniel B; Fan, Jinjiang; Culty, Martine; Papadopoulos, Vassilios (October 2014).
435:
382:
935:"The neurosteroid pregnenolone is synthesized by a mitochondrial P450 enzyme other than CYP11A1 in human glial cells"
734:
284:. At USC his research focuses on Leydig cell development and the role of TSPO in non-alcoholic fatty liver disease.
100:
Degree of Extensive Studies (MSc) in Animal Biology and Physiology, University Pierre and Marie Curie, Paris, France
185:
154:
126:
117:, is a scholar, researcher, inventor, professor, and university administrator who has served as dean of the
2134:
2065:
351:
347:
118:
335:
130:
1316:
Li, Jiehan; Daly, Edward; Campioli, Enrico; Wabitsch, Martin; Papadopoulos, Vassilios (January 2014).
2129:
1989:
1976:
Campioli, Enrico; Lee, Sunghoon; Lau, Matthew; Marques, Lucas; Papadopoulos, Vassilios (2017-09-11).
1620:
1507:
1439:
1205:
1050:
1002:
269:
92:
Doctorate Degree of Health and Life Sciences (PhD), University Pierre and Marie Curie, Paris, France
1978:"Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism"
1669:"Protein-Protein Interactions Mediate Mitochondrial Cholesterol Transport and Steroid Biosynthesis"
1145:"The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis"
299:
197:
1905:
1810:
1549:
1408:
1298:
810:
711:
481:
200:
regulation of Leydig cell function. Afterwards, Papadopoulos completed postdoctoral training at
876:"Mechanisms Mediating Environmental Chemical-Induced Endocrine Disruption in the Adrenal Gland"
2023:
2005:
1958:
1950:
1897:
1889:
1854:
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602:
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555:
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511:
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244:
414:
of Pharmacy and Pharmaceutical Sciences, the largest gift for pharmacy school in California.
172:, Papadopoulos performed research at the Institute of Biological Research and Biotechnology,
2013:
1997:
1940:
1881:
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revealed an impact on testicular function. Endocrine disrupting chemicals such as phthalate
339:
355:
331:
311:
307:
181:
933:
Lin, Yiqi Christina; Cheung, Garett; Porter, Edith; Papadopoulos, Vassilios (July 2022).
1993:
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1209:
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2018:
1977:
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1038:
969:
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910:
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797:
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622:"Isolation and characterization of protein kinase C from Y-1 adrenal cell cytoskeleton"
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114:
30:
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71:
1909:
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1302:
814:
715:
249:
1945:
1928:
133:
from 2005 to 2007, and the executive director and chief scientific officer of the
1014:
153:
in Paris (Doctor in Pharmacy) in 1984. Papadopoulos continued his education as a
390:
374:
217:
213:
193:
2001:
1519:
1192:
Papadopoulos, V; Guarneri, P; Kreuger, K E; Guidotti, A; Costa, E (June 1992).
1062:
951:
2009:
1954:
1893:
1850:
1798:
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1962:
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1545:
1479:
1404:
1361:
1080:
1022:
978:
919:
857:
806:
515:
188:. At Université Pierre et Marie Curie, Papadopoulos engaged in research on
1648:
1596:
1294:
1245:
1178:
1129:
841:
707:
663:
637:
606:
590:
559:
780:
281:
189:
169:
1733:
1259:
Costa, E.; Auta, J.; Guidotti, A.; Korneyev, A.; Romeo, E. (June 1994).
236:, the American Association of Pharmaceutical Scientists (AAPS), and the
1388:
327:
874:
Martinez-Arguelles, Daniel B.; Papadopoulos, Vassilios (2015-03-04).
343:
229:
209:
158:
1790:
1667:
Liu, Jun; Rone, Malena B.; Papadopoulos, Vassilios (December 2006).
1143:
Papadopoulos, V; Mukhin, A G; Costa, E; Krueger, K E (March 1990).
90:
Degree in Pharmacy (DPharm), University of Athens, Athens, Greece
2084:
USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences
739:
USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences
366:
At Georgetown, studies on in utero and adult in vivo exposure to
119:
USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences
37:
USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences
228:
Vassilios has published more than 300 papers and holds numerous
346:. Moreover, the identification of a brain-specific pathway for
1318:"De Novo Synthesis of Steroids and Oxysterols in Adipocytes"
2080:"USC School of Pharmacy announces $ 50 million naming gift"
342:
for neurological disorders, neuropsychiatric diseases, and
1265:
The Journal of Steroid Biochemistry and Molecular Biology
408:
Research Institute of the McGill University Health Centre
135:
Research Institute of the McGill University Health Center
306:
induces the formation of a cytosolic and mitochondrial
1569:
The Journal of Clinical Endocrinology & Metabolism
571:
569:
263:
In 1988, Papadopoulos was appointed to the faculty of
145:
Papadopoulos holds a degree in pharmacy (DPharm) from
63:
Professor of Pharmacology and Pharmaceutical Sciences
61:
John Stauffer Dean’s Chair in Pharmaceutical Sciences
350:
steroid synthesis led to the development of a novel
234:
American Association for the Advancement of Science
113:DPharm, PhD, DSc (hon), born February 18, 1961, in
86:
81:
67:
55:
43:
18:
1094:Krueger, K.E.; Papadopoulos, V. (September 1990).
2042:"Vassilios Papadopoulos, DPharm, PhD, DSc (hon)"
869:
867:
758:
756:
754:
735:"Vassilios Papadopoulos, DPharm, PhD, DSc (Hon)"
436:"Vassilios Papadopoulos, DPharm, PhD, DSc (hon)"
243:Papadopoulos’ research focuses the cellular and
1432:Proceedings of the National Academy of Sciences
1198:Proceedings of the National Academy of Sciences
482:"An interview with Dr. Vassilios Papadopoulos"
2140:American university and college faculty deans
208:, Sydney, Australia, researching the role of
8:
1261:"The pharmacology of neurosteroidogenesis"
29:
15:
2125:University of Southern California faculty
2017:
1944:
1749:
1684:
1535:
1469:
1451:
1351:
1333:
1276:
1235:
1217:
1160:
1111:
1070:
968:
950:
909:
891:
796:
653:
620:Papadopoulos, V; Hall, P F (1989-02-01).
497:
338:. Currently, several TSPO ligands are in
265:Georgetown University School of Medicine
422:
176:in Athens, Greece where he focused on
1921:
1919:
1771:
1769:
1662:
1660:
1658:
475:
310:involved in cholesterol targeting to
174:National Hellenic Research foundation
149:in 1982 before completing his PhD at
7:
2115:Greek emigrants to the United States
729:
727:
725:
680:Molecular and Cellular Endocrinology
473:
471:
469:
467:
465:
463:
461:
459:
457:
455:
430:
428:
426:
354:blood diagnostic and the design of
238:Canadian Academy of Health Sciences
14:
123:University of Southern California
1886:10.1111/j.1365-2826.2011.02167.x
314:family 11 subfamily A member 1 (
258:nonalcoholic fatty liver disease
151:Université Pierre et Marie Curie
1673:Journal of Biological Chemistry
1322:Journal of Biological Chemistry
1149:Journal of Biological Chemistry
1100:Journal of Biological Chemistry
939:Journal of Biological Chemistry
532:Journal of Steroid Biochemistry
220:transport and steroidogenesis.
1831:Journal of Alzheimer's Disease
362:Endocrine disrupting chemicals
1:
1946:10.1095/biolreprod.107.065649
1874:Journal of Neuroendocrinology
1779:Nature Reviews Drug Discovery
1162:10.1016/s0021-9258(19)39661-9
1113:10.1016/s0021-9258(18)77217-7
304:luteinizing hormone receptors
206:University of New South Wales
1278:10.1016/0960-0760(94)90284-4
1015:10.1016/j.envres.2015.03.036
692:10.1016/0303-7207(89)90078-6
544:10.1016/0022-4731(86)90385-7
2156:
2002:10.1038/s41598-017-11325-7
1520:10.1016/j.isci.2021.102457
1063:10.1016/j.isci.2021.102457
880:Frontiers in Endocrinology
332:neuropsychiatric disorders
952:10.1016/j.jbc.2022.102110
836:(2): 109–345. June 2003.
389:reduced testosterone and
302:binding to Leydig cells'
104:
77:
28:
2110:American pharmacologists
2066:"Vassilios Papadopoulos"
893:10.3389/fendo.2015.00029
830:Endocrine-Related Cancer
579:Journal of Endocrinology
288:Contributions to Science
248:research has focused on
202:Prince of Wales Hospital
155:post-doctoral researcher
1933:Biology of Reproduction
1843:10.3233/jad-2011-101941
1633:10.1126/science.7777858
1453:10.1073/pnas.1908207116
1335:10.1074/jbc.m113.534172
1219:10.1073/pnas.89.11.5113
769:Molecular Endocrinology
626:Journal of Cell Biology
486:Biology of Reproduction
480:Yan, Wei (2021-11-15).
127:Los Angeles, California
111:Vassilios Papadopoulos,
2120:Scientists from Athens
1686:10.1074/jbc.m608820200
1581:10.1210/jcem-72-6-1332
995:Environmental Research
499:10.1093/biolre/ioab137
385:and the non-phthalate
348:dehydroepiandrosterone
322:Neurosteroid formation
168:During his studies in
23:DPharm, PhD, DSc (hon)
20:Vassilios Papadopoulos
842:10.1677/erc.0.0100109
638:10.1083/jcb.108.2.553
591:10.1677/joe.0.1140459
397:Administrative career
336:neurological diseases
131:Georgetown University
59:Dean, USC Mann School
781:10.1210/me.2012-1159
368:endocrine disrupting
340:clinical development
270:translocator protein
147:University of Athens
1994:2017NatSR...711072C
1734:10.1038/mt.2014.116
1679:(50): 38879–38893.
1625:1995Sci...268.1609B
1619:(5217): 1609–1612.
1512:2021iSci...24j2457L
1444:2019PNAS..11623274L
1438:(46): 23274–23283.
1210:1992PNAS...89.5113P
1106:(25): 15015–15022.
1055:2021iSci...24j2457L
1007:2015ER....140..145C
300:luteinizing hormone
224:Career and research
137:from 2007 to 2015.
82:Academic background
47:February 18th, 1961
1982:Scientific Reports
1389:10.1002/pros.23146
377:with collaborator
1728:(10): 1779–1791.
1722:Molecular Therapy
1204:(11): 5113–5117.
775:(11): 1868–1882.
186:steroid receptors
108:
107:
2147:
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2069:
2062:
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2055:
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2038:
2032:
2031:
2021:
1973:
1967:
1966:
1948:
1939:(6): 1018–1028.
1923:
1914:
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1825:
1819:
1818:
1773:
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1753:
1713:
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1653:
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1607:
1601:
1600:
1575:(6): 1332–1339.
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1473:
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1423:
1417:
1416:
1372:
1366:
1365:
1355:
1337:
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1307:
1306:
1280:
1271:(4–6): 385–389.
1256:
1250:
1249:
1239:
1221:
1189:
1183:
1182:
1164:
1155:(7): 3772–3779.
1140:
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1133:
1115:
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1085:
1084:
1074:
1033:
1027:
1026:
989:
983:
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871:
862:
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819:
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731:
720:
719:
674:
668:
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657:
617:
611:
610:
573:
564:
563:
538:(6): 1211–1216.
526:
520:
519:
501:
492:(5): 1070–1074.
477:
450:
449:
447:
446:
432:
182:steroid hormones
178:adrenal function
33:
16:
2155:
2154:
2150:
2149:
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2146:
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2144:
2100:
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2098:
2089:
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2040:
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2035:
1975:
1974:
1970:
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1924:
1917:
1871:
1870:
1866:
1827:
1826:
1822:
1791:10.1038/nrd3295
1785:(12): 971–988.
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1774:
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1714:
1710:
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1665:
1656:
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1608:
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1425:
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1310:
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1191:
1190:
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1093:
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1088:
1035:
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1030:
991:
990:
986:
932:
931:
927:
873:
872:
865:
827:
826:
822:
762:
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752:
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732:
723:
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619:
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614:
575:
574:
567:
528:
527:
523:
479:
478:
453:
444:
442:
434:
433:
424:
420:
399:
356:neuroprotective
312:cytochrome P450
308:protein complex
293:Steroidogenesis
290:
226:
143:
62:
60:
51:
48:
39:
24:
21:
12:
11:
5:
2153:
2151:
2143:
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