24:
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Colby, D.W.; P. Garg; G. Chao; J. Webster; A. Messer; V.M. Ingram; K.D. Wittrup (17 September 2004). "Development of a Human
Variable Light Chain Domain Intracellular Antibody against Huntingtin via Yeast Surface Display".
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This was the first time a researcher demonstrated that a single amino acid exchange in a protein can cause a disease or disorder. As a result, Vernon Ingram is sometimes referred to as "The father of
Molecular Medicine."
1218:
1228:
858:
Ingram, V.M. (2004). "The Role of
Alzheimer Aβ Peptides in Ion Transport across Cell Membranes, in Subcellular Biochemistry: Alzheimer's Disease". In Harris, R.; Fahrenholz, F. (eds.).
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was a disease of the neurofilaments; this turned out not to be the cause, but it was noted that people with Down syndrome did develop
Alzheimer's Disease by the time they were 40.
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After retirement, Ingram continued his research, maintaining a small laboratory at MIT. He and his wife, Beth, were housemasters of
Ashdown House at MIT for 16 years.
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465:. His interest was sparked by the work his second wife, Elizabeth (Beth), was doing with intellectually disabled people in the Boston area. She had heard that
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Blanchard, B.J.; A. Chen; C. Kelly; K. Stafford; B. Stockwell; V.M. Ingram (2004). "Novel
Compounds eliminate the Neurotoxicity of the Alzheimer Aβ Peptide".
969:
by a small molecule
Barbara J. Blanchard, Albert Chen, Leslie M. Rozeboom, Kate A. Stafford, Peter Weigele, and Vernon M. Ingram PNAS 2004 101: 14326-14332
450:
faculty in 1958, intending to stay for only one year. He found that he enjoyed it there so much that he stayed on. While at MIT, Ingram collaborated with
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Ingram, V.M.; B.J. Blanchard; A. Chen; C. Kelly; K. Stafford; B. Stockwell (2004). "Blocking the
Initial Molecular Mechanism of Alzheimer's Disease".
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Hunt, J.A.; V.M. Ingram (1958). "Abnormal Human
Haemoglobins. II. The Chymotryptic Digestion of the Trypsin-resistant Core of Haemoglobins A and S".
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296:
436:
107:
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Webster, J.M.; D.W. Colby; V.M. Ingram; K.D. Wittrup; A. Messer (November 2004). "Enhanced anti-Huntington's
Disease Intrabodies".
1253:
815:"Sickle-cell anemia hemoglobin: the molecular biology of the first "molecular disease"--the crucial importance of serendipity"
745:"Sickle-cell anemia hemoglobin: the molecular biology of the first "molecular disease"--the crucial importance of serendipity"
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41:
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Ingram, V.M. (1957). "Gene Mutations in Human Hemoglobin: The Chemical Difference between Normal and Sickle Hemoglobin".
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287:
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535:
Ingram, V.M. (1956). "A Specific Chemical Difference between Globins of Normal and Sickle-cell Anemia Hemoglobins".
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on haemoglobin research. He was also interested in embryonic haemoglobin and how it differed from that of adults.
34:
914:"Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule"
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differed due to a single substituted amino acid residue. Much of this work was done with the support of
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Inaugural Article: Efficient reversal of Alzheimer's disease fibril formation and elimination of
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338:, Ingram worked at a chemical factory producing drugs for the war effort and at night studied at
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It's in the Blood! A Documentary History of Linus Pauling, Hemoglobin, and Sickle Cell Anemia
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Blanchard, B.J.; A. Chen; K. Stafford; P. Weigele; V.M. Ingram (5 October 2004).
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After receiving his doctorate, Ingram worked at postdoctoral appointments at the
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Proceedings of the National Academy of Sciences of the United States of America
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on crystallising proteins. While at Yale, he studied peptide chemistry with
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Abstr. Massachusetts Alzheimer's Disease Research Center, Annual meeting
331:) and settled in England. He then Anglicised his name to Vernon Ingram.
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By the 1980s, Ingram became interested in neuroscience and especially
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291:(May 19, 1924 – August 17, 2006) was a German–American professor of
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Ingram, V.M. (4 March 1961). "Gene Evolution and the Hæmoglobins".
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Abstr. International Congress on Alzheimer's Disease, Philadelphia
369:. In 1952, Ingram returned to England and started working at the
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Members of the United States National Academy of Sciences
1187:"'Father of Molecular Medicine' Vernon Ingram Dies at 82"
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Jewish emigrants from Nazi Germany to the United Kingdom
494:, on 17 August 2006 of injuries stemming from a fall.
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is named in their honour. Ingram was Director of the
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in position 6 of the β-chain of the normal protein by
701:"Peptide Chain Synthesis of Human Hemoglobins A and A
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Biographical Memoirs of Fellows of the Royal Society
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48:. Unsourced material may be challenged and removed.
1200:Obituary of Vernon Ingram from the MIT News Office
1000:"Vernon Martin Ingram. 19 May 1924—17 August 2006"
350:in 1945 and a PhD in organic chemistry in 1949.
8:
1042:. Genome Biology. 2 May 2002. Archived from
862:. London: Kluwer Academic/Plenum Publishers.
699:Winslow, R.M.; V.M. Ingram (10 March 1966).
1067:"Surprise! High-flying Tribute for Ingrams"
998:Crowther, R. A.; Kilmartin, J. V. (2022).
319:. When he was 14, he and his family left
130:
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1234:People from the Province of Lower Silesia
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860:Cellular and Molecular Aspects of Amyloid
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108:Learn how and when to remove this message
1239:Alumni of Birkbeck, University of London
990:
1259:British emigrants to the United States
396:and trait was the substitution of the
346:. He received a bachelor's degree in
297:Massachusetts Institute of Technology
7:
1135:Davis, Tinsley H. (5 October 2004).
46:adding citations to reliable sources
1126:Key Participants: Vernon M. Ingram
437:American Society of Human Genetics
388:determined that the change in the
361:. At Rockefeller, he worked with
14:
1065:Darren J. Clarke (17 July 2002).
1185:Trafton, Anne (22 August 2006).
22:
1137:"Biography of Vernon M. Ingram"
1040:"2002 National Academy Fellows"
323:because of their opposition to
33:needs additional citations for
1091:. MIT News Office. 15 May 2002
377:, studying protein chemistry.
1:
725:10.1016/S0021-9258(18)96814-6
623:Biochimica et Biophysica Acta
416:sequence of normal human and
309:Werner Adolf Martin Immerwahr
143:Werner Adolf Martin Immerwahr
1249:Fellows of the Royal Society
1089:"Three Faculty Named to NAS"
635:10.1016/0006-3002(58)90517-1
485:National Academy of Sciences
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743:Ingram, Vernon M. (2004).
884:10.1016/j.jmb.2004.07.054
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129:
1122:radio show 12 March 2003
831:10.1534/genetics.167.1.1
764:10.1534/genetics.167.1.1
506:(intracellular antibody)
481:Experimental Study Group
1254:20th-century biologists
1157:10.1073/pnas.0406677101
939:10.1073/pnas.0405941101
375:University of Cambridge
1114:Vernon Ingram Playlist
1017:10.1098/rsbm.2022.0023
979:MIT Biology Department
918:Proc Natl Acad Sci USA
903:Abstract Soc. Neurosci
1116:Appearance on WMBR's
813:Ingram, V.M. (2004).
529:Selected publications
492:Boston, Massachusetts
386:Antony O. W. Stretton
355:Rockefeller Institute
186:Boston, Massachusetts
514:Huntington's disease
371:Cavendish Laboratory
344:University of London
283:Vernon Martin Ingram
205:University of London
124:Vernon Martin Ingram
42:improve this article
1244:American biologists
1150:(40): 14323–14325.
930:2004PNAS..10114326B
666:1961Natur.189..704I
549:1956Natur.178..792I
519:Sickle cell anaemia
463:Alzheimer's disease
456:Columbia University
433:William Allan Award
418:sickle cell anaemia
394:sickle cell disease
231:William Allan Award
1119:Dinnertime Sampler
1046:on 29 January 2005
446:Ingram joined the
431:. Ingram won the
1189:. MIT News Office
1069:. MIT News Office
660:(4766): 704–708.
590:(4581): 326–328.
543:(4537): 792–794.
412:to show that the
380:In 1956, Ingram,
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340:Birkbeck College
336:Second World War
307:Ingram was born
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266:Doctoral advisor
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406:electrophoresis
404:. Ingram used
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201:Alma mater
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31:This article
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1191:. Retrieved
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392:molecule in
382:John A. Hunt
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363:Moses Kunitz
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321:Nazi Germany
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255:Institutions
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180:(2006-08-17)
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40:Please help
35:verification
32:
15:
1224:2006 deaths
1214:1924 births
1010:: 315–331.
477:6285 Ingram
390:haemoglobin
334:During the
271:Fred Barrow
193:Nationality
153:19 May 1924
1208:Categories
1193:26 October
1095:25 October
1073:25 October
1050:25 October
985:References
825:(1): 1–7.
758:(1): 1–7.
523:Hemoglobin
510:Huntingtin
487:in 2002.
452:Paul Marks
425:Max Perutz
414:amino acid
149:1924-05-19
68:newspapers
1026:251447271
504:Intrabody
439:in 1967.
435:from the
348:chemistry
303:Biography
159:, Germany
1176:15454612
973:See also
958:15388848
892:15342245
849:15166132
819:Genetics
782:15166132
752:Genetics
682:13717731
643:13560405
604:13464827
565:13369537
498:See also
474:Asteroid
219:Children
926:Bibcode
840:1470873
773:1470873
734:5933872
690:4201541
662:Bibcode
612:4161107
573:4167855
545:Bibcode
373:at the
342:at the
327:(being
313:Breslau
295:at the
293:biology
250:Biology
163:Wrocław
157:Breslau
82:scholar
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654:Nature
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584:Nature
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537:Nature
402:valine
384:, and
329:Jewish
325:Nazism
247:Fields
234:(1967)
227:Awards
211:Spouse
196:German
167:Poland
84:
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1140:(PDF)
1022:S2CID
748:(PDF)
708:(PDF)
686:S2CID
608:S2CID
569:S2CID
161:(now
89:JSTOR
75:books
1195:2006
1172:PMID
1097:2006
1075:2006
1052:2006
954:PMID
888:PMID
845:PMID
778:PMID
730:PMID
678:PMID
639:PMID
600:PMID
561:PMID
521:and
512:and
427:and
408:and
357:and
175:Died
139:Born
61:news
1162:PMC
1152:doi
1148:101
1012:doi
944:PMC
934:doi
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880:doi
876:342
835:PMC
827:doi
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768:PMC
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720:doi
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670:doi
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454:of
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