1234:
mRNA produces 4 distinct versican isoforms that differ in their potential number of GAG chains. All isoforms have homologous N-terminal (HA binding) and C-terminal (lectin-like) domains. The central domain of versican V0 contains both the GAG-α and GAG-β domains. V1 isoforms has the GAG-β domain, V2 has the GAG-α domain, and V3 is void of any GAG attachment domains, and only consists of the N-terminal and C-terminal globular domains. It is known that the isoforms are differentially expressed in different tissue types. The biological significance of alternative splicing is yet to be determined.
242:
219:
116:
141:
507:
500:
493:
248:
147:
1238:
formation of immobilized gradients of these factors, their protection from proteolytic cleavage, and their presentation to specific cell-surface receptors. The binding of versican with leukocyte adhesion molecules L-selectin, P-selectin, and CD44 is also mediated by the interaction of CS chains of versican with the
1243:
interaction down-regulates the chemokines function. Recently, in light of results that V1 and V2 isoforms of versican have opposite effects on cell proliferation, glycosaminoglycan domain GAG-β has been implicated in versican-enhanced cell proliferation and versican-induced reduction of cell apoptosis.
1180:
Versican occurs in 5 isoforms : V0, V1, V2, V3, V4. The central domain of versican V0 contains both the GAG-α and GAG-β domains. V1 isoforms has the GAG-β domain, V2 has the GAG-α domain, V3 is void of any GAG attachment domains and V4 has a portion of the GAG-β domain. The GAGs, being composed
1233:
The central domain of
Versican is decorated with glycosaminoglycans. The structural and functional diversity of Versican is increased by variations in GAG sulfation patterns and the type of GAG chains bound to the core protein. There is a single versican gene, however alternative splicing of its
1242:
of these molecules. Both CD44 and L-selectin have been implicated in leukocyte trafficking. The ability of versican to bind a large panel of chemokines and the biological consequences of such binding has also been examined. Versican can bind specific chemokines through its CS chains and this
1237:
Because of their negatively charged sulfates or carboxyl groups, chondroitin sulfate chains are attracted to various positively charged molecules such as certain growth factors, cytokines, and chemokines. This interaction in the extracellular matrix or on the cell surface is important in the
1208:
Expression of versican is observed in various adult tissues such as blood vessels, skin, and developing heart. Smooth muscle cells of blood vessels, epithelial cells of skin, and the cells of central and peripheral nervous system are a few examples of cell types that express versican
2545:
Perveen R, Hart-Holden N, Dixon MJ, Wiszniewski W, Fryer AE, Brunner HG, Pinkners AJ, van
Beersum SE, Black GC (1999). "Refined genetic and physical localization of the Wagner disease (WGN1) locus and the genes CRTL1 and CSPG2 to a 2- to 2.5-cM region of chromosome 5q14.3".
1118:
with an apparent molecular mass of more than 1000kDa. In 1989, Zimmermann and
Ruoslahti cloned and sequenced the core protein of fibroblast chondroitin sulfate proteoglycan. They designated it versican in recognition of its versatile modular structure.
2286:
Brown DM, Graemiger RA, Hergersberg M, Schinzel A, Messmer EP, Niemeyer G, Schneeberger SA, Streb LM, Taylor CM, Kimura AE (1995). "Genetic linkage of Wagner disease and erosive vitreoretinopathy to chromosome 5q13-14".
2394:
Yao LY, Moody C, Schönherr E, Wight TN, Sandell LJ (1994). "Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry".
1188:(EGF) repeats, a C-type lectin domain and complement regulatory protein (CRP)-like domain. The C-terminal domain binds a variety of ligands in ECM which contribute significantly to the functions of lecticans.
1200:
has been extensively studied. Versican is often considered an anti-adhesion molecule. Considering the large size (>1000 kDa) and hydration capability of versican, it is possible that the interaction of
1659:"The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety"
1142:(nervous system proteoglycans) as other members. Versican is also known as chondroitin sulfate proteoglycan core protein 2 or chondroitin sulfate proteoglycan 2 (CSPG2), and PG-M.
1822:
Andersson-Sjöland A, Hallgren O, Rolandsson S, Weitoft M, Tykesson E, Larsson-Callerfelt AK, Rydell-Törmänen K, Bjermer L, Malmström A, Karlsson JC, Westergren-Thorsson G (2015).
1267:, a protein whose expression is associated with that of versican in the developing heart. The EGF domain of the C-terminal of versican also binds the EGF-receptor molecule
1290:, where it may stabilize synaptic connections. Versican can also inhibit nervous system regeneration and axonal growth following an injury to the central nervous system.
2072:
Iozzo RV, Naso MF, Cannizzaro LA, Wasmuth JJ, McPherson JD (1993). "Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14)".
1521:
Iozzo RV, Naso MF, Cannizzaro LA, Wasmuth JJ, McPherson JD (1992). "Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14)".
1255:
family. For example, The C-lectin domain of versican interacts with tenascin R through its fibronectin type III (FnIII) repeat 3-5 domain in a calcium dependent manner,
255:
154:
2672:
GeneReviews/NCBI/NIH/UW entry on VCAN-Related
Vitreoretinopathy Includes: Wagner Vitreoretinal Degeneration (Wagner Syndrome), Erosive Vitreoretinopathy (ERVR)
1209:
physiologically. Versican is involved in development, guiding embryonic cell migration important in the formation of the heart and outlining the path for
1279:
Versican is a key factor in inflammation through interactions with adhesion molecules on the surfaces of inflammatory leukocytes and interactions with
795:
776:
77:
2512:"Phospholipase A2 type II binds to extracellular matrix biglycan: modulation of its activity on LDL by colocalization in glycosaminoglycan matrixes"
2996:
2658:
Versican identified as a direct miR-126a-5p target that induces telomere shortening, senescence, and nuclear factor κB (NF-κB) pathway activator
1259:. Different tenascin domains interact with a wide range of cellular receptors, including integrins, cell adhesion molecules and members of the
3556:
1298:
Increased versican expression is often observed in tumor growth in tissues such as breast, brain, ovary, gastrointestinal tract, prostate, and
2353:"Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues"
1489:
1346:
1471:
3541:
241:
3373:
1048:
1041:
218:
3413:
2708:
1310:. A fifth isoform of versican, V4, that is similar to V1 but with a shortened beta-GAG region, is present and upregulated in human
3263:
1507:
1115:
1458:
1437:
2136:
Bignami A, Lane WS, Andrews D, Dahl D (1989). "Structural similarity of hyaluronate binding proteins in brain and cartilage".
2828:
1454:
140:
115:
2469:"Binding of human phospholipase A2 type II to proteoglycans. Differential effect of glycosaminoglycans on enzyme activity"
1433:
2894:
1251:
The C-terminal of
Versican interacts with a variety of molecules in the matrix. One important family of ligands is the
57:
2253:"Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter"
3510:
2989:
2744:
1406:
1239:
254:
153:
3500:
2218:"A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences"
3463:
3423:
2772:
247:
146:
3403:
3378:
2680:
1181:
of repeating disaccharide units, contribute to the negative charge and many other properties of proteoglycans.
840:
65:
2318:"A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican"
3551:
1610:"Versican overexpression in human breast cancer lesions: known and new isoforms for stromal tumor targeting"
1307:
1185:
821:
2974:
2671:
1657:
Aspberg A, Miura R, Bourdoulous S, Shimonaka M, Heinegârd D, Schachner M, Ruoslahti E, Yamaguchi Y (1997).
3438:
2982:
2759:
2701:
1778:
1670:
1362:
1342:
1318:
1222:
1005:
129:
1608:
Kischel P, Waltregny D, Dumont B, Turtoi A, Greffe Y, Kirsch S, De Pauw E, Castronovo V (Feb 2010).
1205:(large family of cell adhesion molecules) with their cell surface receptors is sterically hindered.
44:
3443:
3368:
3255:
3232:
3196:
3168:
2946:
997:
993:
989:
955:
951:
947:
926:
922:
918:
2618:
Yan Y, Qin D, Hu B, Zhang C, Liu S, Wu D, Huang W, Huang X, Wang L, Chen X, Zhang L (April 2019).
3546:
3393:
2571:
2498:
2455:
2382:
2161:
1937:
1747:
1639:
1151:
89:
1001:
963:
959:
914:
2424:
Bode-Lesniewska B, Dours-Zimmermann MT, Odermatt BF, Briner J, Heitz PU, Zimmermann DR (1996).
3468:
3297:
2649:
2620:"Deletion of miR-126a Promoted Hepatic Aging and Inflammation in a Mouse Model of Cholestasis"
2606:
2563:
2533:
2490:
2447:
2412:
2374:
2339:
2304:
2274:
2239:
2204:
2153:
2124:
2089:
2060:
2025:
1982:
1929:
1888:
1853:
1804:
1739:
1698:
1631:
1587:
1538:
1163:
37:
3383:
3200:
3153:
2951:
2766:
2694:
2639:
2631:
2596:
2555:
2523:
2480:
2437:
2404:
2364:
2329:
2296:
2264:
2229:
2194:
2186:
2145:
2114:
2081:
2050:
2015:
2007:
1972:
1919:
1880:
1843:
1835:
1794:
1786:
1765:
Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL, Karin M (Jan 2009).
1729:
1688:
1678:
1621:
1577:
1569:
1530:
1378:
1287:
506:
499:
492:
334:
265:
209:
164:
3340:
3312:
3228:
1225:
by interacting with hyaluronan. Its interactions with link protein has also been studied.
309:
85:
2300:
1871:
Jumper N, Paus R, Bayat A (22 Apr 2015). "Functional histopathology of keloid disease".
1782:
1767:"Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis"
1674:
3490:
3009:
2941:
2644:
2619:
2190:
2020:
1995:
1977:
1960:
1906:
Matsumoto K, Shionyu M, Go M, Shimizu K, Shinomura T, Kimata K, Watanabe H (Oct 2003).
1848:
1823:
1799:
1766:
1573:
2334:
2317:
2269:
2252:
2234:
2217:
2199:
2174:
2119:
2102:
2085:
2055:
2038:
1582:
1557:
1534:
710:
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629:
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619:
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568:
563:
558:
553:
548:
3535:
3495:
3483:
3163:
2958:
2736:
2676:
2408:
2149:
1734:
1717:
1693:
1658:
1354:
1221:
The N-terminal of versican has an important role in maintaining the integrity of the
535:
2575:
2502:
2459:
2426:"Distribution of the large aggregating proteoglycan versican in adult human tissues"
2386:
2165:
1941:
1751:
1643:
3408:
3320:
3187:
3017:
3013:
2884:
2813:
1326:
1210:
1104:
327:
106:
69:
93:
3520:
3515:
3505:
3478:
3448:
3433:
3302:
3158:
3148:
3025:
2467:
Sartipy P, Johansen B, Camejo G, Rosengren B, Bondjers G, Hurt-Camejo E (1996).
1494:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1476:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1409:
with hyaluronan and a link protein (hyaluronan and proteoglycan link protein 1;
1263:
and glypican proteoglycan families. Versican’s C-terminal domain interacts with
1197:
2635:
2103:"Isolation and partial characterization of a glial hyaluronate-binding protein"
410:
3348:
2919:
2528:
2511:
2011:
1824:"Versican in inflammation and tissue remodeling: the impact on lung disorders"
1358:
1174:
1159:
1155:
226:
123:
73:
2601:
2584:
2485:
2468:
1683:
579:
extracellular matrix structural constituent conferring compression resistance
3458:
3453:
3428:
3418:
3330:
2754:
1839:
1330:
1280:
1264:
1202:
1131:
740:
470:
348:
293:
280:
192:
179:
81:
2653:
2610:
2567:
2559:
2369:
2352:
2029:
1986:
1933:
1924:
1907:
1892:
1857:
1808:
1635:
2537:
2494:
2451:
2416:
2378:
2343:
2308:
2278:
2243:
2208:
2157:
2128:
2093:
2064:
1743:
1702:
1591:
1542:
1088:
1083:
3277:
3272:
3267:
3245:
3240:
3213:
3173:
2899:
2889:
2879:
2863:
2858:
2793:
2788:
2778:
2442:
2425:
1961:"Proteoglycans in atherosclerosis and restenosis: key roles for versican"
1299:
1260:
1252:
1170:
1139:
1135:
1127:
1123:
1072:
889:
870:
866:
2583:
Lemire JM, Braun KR, Maurel P, Kaplan ED, Schwartz SM, Wight TN (1999).
1908:"Distinct interaction of versican/PG-M with hyaluronan and link protein"
1790:
3325:
3208:
3005:
2936:
2853:
2848:
2843:
2838:
2833:
2717:
1884:
1303:
852:
807:
1626:
1609:
3398:
3117:
3077:
2963:
2805:
2721:
1410:
1382:
1350:
1321:
in mice to metastasize to lung, liver and adrenal glands, acting via
1311:
1056:
762:
1107:
that is present in a variety of human tissues. It is encoded by the
2686:
3292:
3287:
3132:
3127:
3122:
3112:
3107:
3102:
3082:
3067:
3062:
3047:
3034:
2929:
2924:
2749:
1394:
2175:"Multiple domains of the large fibroblast proteoglycan, versican"
1558:"Multiple domains of the large fibroblast proteoglycan, versican"
725:
721:
3473:
3388:
3282:
3097:
3092:
3087:
3072:
3057:
3052:
3042:
2823:
2818:
2039:"Isolation of a large aggregating proteoglycan from human brain"
1390:
1386:
1374:
1322:
61:
2978:
2690:
515:
2037:
Perides G, Rahemtulla F, Lane WS, Asher RA, Bignami A (1992).
1718:"Differential expression of versican isoforms in brain tumors"
1361:
and other inflammatory cells) can migrate more easily through
1716:
Paulus W, Baur I, Dours-Zimmermann MT, Zimmermann DR (1996).
1184:
The C-terminal (G3) globular domain consists of one or two
1286:
In the adult central nervous system, versican is found in
2101:
Perides G, Lane WS, Andrews D, Dahl D, Bignami A (1989).
2585:"Versican/PG-M isoforms in vascular smooth muscle cells"
317:
2351:
Zako M, Shinomura T, Ujita M, Ito K, Kimata K (1995).
1196:
The role of versican in cell adhesion, migration, and
482:
1353:
and bronchiolitis obliterans syndrome (BOS). Cells (
1283:
that are involved in recruiting inflammatory cells.
3361:
3339:
3311:
3254:
3227:
3195:
3186:
3141:
3033:
3024:
2912:
2872:
2804:
2735:
2728:
1019:
982:
940:
907:
1450:
1448:
1446:
1429:
1427:
1425:
1389:formation becomes uncontrolled and overgrowth of
264:
163:
1169:The N-terminal (G1) globular domain consists of
1373:Deposits of versican are not present in normal
16:Protein-coding gene in the species Homo sapiens
1603:
1601:
1455:GRCm38: Ensembl release 89: ENSMUSG00000021614
48:, CSPG2, ERVR, GHAP, PG-M, WGN, WGN1, versican
2990:
2702:
2510:Sartipy P, Bondjers G, Hurt-Camejo E (1999).
1341:Versican is increased in the changing tissue
8:
2316:Dours-Zimmermann MT, Zimmermann DR (1995).
2216:Krusius T, Gehlsen KR, Ruoslahti E (1987).
1996:"Versican degradation and vascular disease"
1556:Zimmermann DR, Ruoslahti E (October 1989).
1434:GRCh38: Ensembl release 89: ENSG00000038427
569:extracellular matrix structural constituent
3192:
3030:
2997:
2983:
2975:
2732:
2709:
2695:
2687:
736:
531:
305:
204:
101:
2679:at the U.S. National Library of Medicine
2643:
2600:
2527:
2484:
2441:
2368:
2333:
2268:
2251:Naso MF, Zimmermann DR, Iozzo RV (1995).
2233:
2198:
2118:
2054:
2019:
1976:
1923:
1847:
1798:
1733:
1692:
1682:
1625:
1581:
1173:-like loop and two link modules, and has
666:chondroitin sulfate biosynthetic process
635:intracellular membrane-bounded organelle
630:collagen-containing extracellular matrix
3303:Structural maintenance of chromosomes 3
1421:
1345:in inflammatory lung disorders such as
711:post-translational protein modification
1994:Kenagy RD, Plaas AH, Wight TN (2006).
18:
1347:chronic obstructive pulmonary disease
701:dermatan sulfate biosynthetic process
696:chondroitin sulfate catabolic process
269:
230:
225:
168:
127:
122:
7:
2301:10.1001/archopht.1995.01100050139045
1365:that has a higher versican content.
2173:Zimmermann DR, Ruoslahti E (1990).
651:glycosaminoglycan metabolic process
2191:10.1002/j.1460-2075.1989.tb08447.x
1978:10.1161/01.RES.0000126921.29919.51
1574:10.1002/j.1460-2075.1989.tb08447.x
1016:
979:
937:
904:
880:
857:
831:
812:
786:
767:
681:central nervous system development
676:multicellular organism development
487:
405:
343:
322:
14:
3414:Cholesterylester transfer protein
3264:Chondroitin sulfate proteoglycans
1393:tissue occurs at the site of the
671:extracellular matrix organization
2589:Arterioscler. Thromb. Vasc. Biol
2516:Arterioscler. Thromb. Vasc. Biol
1735:10.1097/00005072-199605000-00005
1229:Glycosaminoglycan binding region
1116:chondroitin sulfate proteoglycan
1103:is a large extracellular matrix
505:
498:
491:
253:
246:
240:
217:
152:
145:
139:
114:
2624:Molecular Therapy-Nucleic Acids
1959:Wight TN, Merrilees MJ (2004).
1614:International Journal of Cancer
2829:Myelin-associated glycoprotein
516:More reference expression data
471:More reference expression data
1:
3557:Extracellular matrix proteins
2335:10.1016/S0021-9258(20)30089-2
2270:10.1016/S0021-9258(20)30090-9
2235:10.1016/S0021-9258(18)45176-9
2120:10.1016/S0021-9258(18)83646-8
2086:10.1016/S0888-7543(05)80103-X
2056:10.1016/S0021-9258(18)35919-2
1535:10.1016/S0888-7543(05)80103-X
238:
137:
2895:N-Acetylglucosamine receptor
2409:10.1016/0945-053X(94)90185-6
2150:10.1016/0361-9230(89)90129-9
1663:Proc. Natl. Acad. Sci. U.S.A
1508:"Entrez Gene: VCAN versican"
1385:scarring, a condition where
1150:These proteoglycans share a
3542:Genes on human chromosome 5
3511:Tumor necrosis factor alpha
2745:Asialoglycoprotein receptor
1722:J. Neuropathol. Exp. Neurol
1405:Versican has been shown to
1240:carbohydrate-binding domain
656:skeletal system development
620:endoplasmic reticulum lumen
3573:
3501:Thyroxine-binding proteins
2636:10.1016/j.omtn.2019.04.002
691:osteoblast differentiation
3464:Serum amyloid P component
3424:Colony-stimulating factor
2773:proteochondroitin sulfate
2529:10.1161/01.ATV.18.12.1934
2012:10.1016/j.tcm.2006.03.011
1490:"Mouse PubMed Reference:"
1472:"Human PubMed Reference:"
1317:Versican is required for
1177:(HA) binding properties.
1087:
1082:
1078:
1071:
1055:
1036:
1023:
986:
975:
944:
911:
900:
887:
883:
864:
860:
851:
838:
834:
819:
815:
806:
793:
789:
774:
770:
761:
746:
739:
735:
719:
554:glycosaminoglycan binding
534:
530:
513:
490:
481:
468:
417:
408:
387:Descending thoracic aorta
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
3404:B-cell activating factor
3379:Alpha 1-antichymotrypsin
2681:Medical Subject Headings
2602:10.1161/01.ATV.19.7.1630
2486:10.1074/jbc.271.42.26307
1684:10.1073/pnas.94.19.10116
1122:Versican belongs to the
379:tendon of biceps brachii
1308:peritoneal mesothelioma
1186:Epidermal growth factor
1166:(GAG) binding regions.
1049:Chr 13: 89.8 – 89.89 Mb
1042:Chr 5: 83.47 – 83.58 Mb
574:hyaluronic acid binding
3439:Membrane glycoproteins
2560:10.1006/geno.1999.5766
2430:J. Histochem. Cytochem
2370:10.1074/jbc.270.8.3914
2000:Trends Cardiovasc. Med
1925:10.1074/jbc.M305060200
2760:Mannan-binding lectin
1840:10.1093/glycob/cwu120
1377:but are found in the
1294:Cancer and metastasis
1275:Clinical significance
1126:protein family, with
367:right coronary artery
271:13 C3|13 45.5 cM
232:Chromosome 13 (mouse)
2443:10.1177/44.4.8601689
1363:extracellular matrix
1343:extracellular matrix
1319:Lewis lung carcinoma
1114:Versican is a large
706:glial cell migration
625:extracellular region
600:extracellular matrix
564:carbohydrate binding
445:maxillary prominence
130:Chromosome 5 (human)
3444:Myelin protein zero
3369:Activin and inhibin
3169:Phytohaemagglutinin
2947:Phytohaemagglutinin
1873:Histol. Histopathol
1791:10.1038/nature07623
1783:2009Natur.457..102K
1675:1997PNAS...9410116A
615:extracellular space
549:calcium ion binding
3394:Asialoglycoprotein
2263:(52): 32999–3008.
1885:10.14670/HH-11-624
1879:(11624): 1033–57.
841:ENSMUSG00000021614
644:Biological process
588:Cellular component
542:Molecular function
3529:
3528:
3469:Sialoglycoprotein
3357:
3356:
3298:Platelet factor 4
3182:
3181:
2972:
2971:
2908:
2907:
1627:10.1002/ijc.24812
1288:perineuronal nets
1164:glycosaminoglycan
1098:
1097:
1094:
1093:
1067:
1066:
1032:
1031:
1013:
1012:
971:
970:
934:
933:
896:
895:
877:
876:
847:
846:
828:
827:
802:
801:
783:
782:
731:
730:
526:
525:
522:
521:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
3564:
3384:Apolipoprotein H
3193:
3154:Intrinsic factor
3031:
2999:
2992:
2985:
2976:
2952:Pokeweed mitogen
2767:Mannose receptor
2733:
2711:
2704:
2697:
2688:
2660:
2647:
2614:
2604:
2579:
2541:
2531:
2506:
2488:
2479:(42): 26307–14.
2463:
2445:
2420:
2390:
2372:
2347:
2337:
2312:
2289:Arch. Ophthalmol
2282:
2272:
2247:
2237:
2212:
2202:
2169:
2132:
2122:
2097:
2068:
2058:
2033:
2023:
1990:
1980:
1946:
1945:
1927:
1918:(42): 41205–12.
1903:
1897:
1896:
1868:
1862:
1861:
1851:
1819:
1813:
1812:
1802:
1762:
1756:
1755:
1737:
1713:
1707:
1706:
1696:
1686:
1669:(19): 10116–21.
1654:
1648:
1647:
1629:
1605:
1596:
1595:
1585:
1553:
1547:
1546:
1518:
1512:
1511:
1504:
1498:
1497:
1486:
1480:
1479:
1468:
1462:
1452:
1441:
1431:
1379:reticular dermis
1213:cell migration.
1080:
1079:
1051:
1044:
1027:
1017:
1008:
980:
976:RefSeq (protein)
966:
938:
929:
905:
881:
858:
832:
813:
787:
768:
737:
661:cell recognition
532:
518:
509:
502:
495:
488:
473:
441:efferent ductule
437:semi-lunar valve
421:genital tubercle
413:
411:Top expressed in
406:
371:ventricular zone
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
94:VCAN - orthologs
47:
40:
19:
3572:
3571:
3567:
3566:
3565:
3563:
3562:
3561:
3532:
3531:
3530:
3525:
3353:
3335:
3307:
3250:
3223:
3178:
3137:
3020:
3003:
2973:
2968:
2904:
2868:
2800:
2724:
2715:
2668:
2663:
2617:
2582:
2544:
2522:(12): 1934–41.
2509:
2466:
2423:
2393:
2350:
2328:(52): 32992–8.
2315:
2285:
2250:
2228:(27): 13120–5.
2215:
2185:(10): 2975–81.
2172:
2138:Brain Res. Bull
2135:
2100:
2071:
2049:(33): 23883–7.
2036:
1993:
1958:
1954:
1952:Further reading
1949:
1905:
1904:
1900:
1870:
1869:
1865:
1821:
1820:
1816:
1777:(7225): 102–6.
1764:
1763:
1759:
1715:
1714:
1710:
1656:
1655:
1651:
1607:
1606:
1599:
1568:(10): 2975–81.
1555:
1554:
1550:
1520:
1519:
1515:
1506:
1505:
1501:
1488:
1487:
1483:
1470:
1469:
1465:
1453:
1444:
1432:
1423:
1419:
1403:
1371:
1339:
1296:
1277:
1249:
1231:
1219:
1194:
1148:
1089:View/Edit Mouse
1084:View/Edit Human
1047:
1040:
1037:Location (UCSC)
1025:
1004:
1000:
996:
992:
988:
962:
958:
954:
950:
946:
925:
921:
917:
913:
869:
822:ENSG00000038427
715:
639:
605:lysosomal lumen
583:
559:protein binding
514:
504:
503:
497:
496:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
395:ascending aorta
393:
391:trabecular bone
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
3570:
3568:
3560:
3559:
3554:
3552:C-type lectins
3549:
3544:
3534:
3533:
3527:
3526:
3524:
3523:
3518:
3513:
3508:
3503:
3498:
3493:
3491:Thrombopoietin
3488:
3487:
3486:
3481:
3476:
3466:
3461:
3456:
3451:
3446:
3441:
3436:
3431:
3426:
3421:
3416:
3411:
3406:
3401:
3396:
3391:
3386:
3381:
3376:
3371:
3365:
3363:
3359:
3358:
3355:
3354:
3352:
3351:
3345:
3343:
3337:
3336:
3334:
3333:
3328:
3323:
3317:
3315:
3309:
3308:
3306:
3305:
3300:
3295:
3290:
3285:
3280:
3275:
3270:
3260:
3258:
3252:
3251:
3249:
3248:
3243:
3237:
3235:
3225:
3224:
3222:
3221:
3216:
3211:
3205:
3203:
3190:
3184:
3183:
3180:
3179:
3177:
3176:
3171:
3166:
3161:
3156:
3151:
3145:
3143:
3139:
3138:
3136:
3135:
3130:
3125:
3120:
3115:
3110:
3105:
3100:
3095:
3090:
3085:
3080:
3075:
3070:
3065:
3060:
3055:
3050:
3045:
3039:
3037:
3028:
3022:
3021:
3010:glycoconjugate
3004:
3002:
3001:
2994:
2987:
2979:
2970:
2969:
2967:
2966:
2961:
2956:
2955:
2954:
2949:
2944:
2942:Concanavalin A
2934:
2933:
2932:
2927:
2916:
2914:
2910:
2909:
2906:
2905:
2903:
2902:
2897:
2892:
2887:
2882:
2876:
2874:
2870:
2869:
2867:
2866:
2861:
2856:
2851:
2846:
2841:
2836:
2831:
2826:
2821:
2816:
2810:
2808:
2802:
2801:
2799:
2798:
2797:
2796:
2791:
2786:
2781:
2769:
2764:
2763:
2762:
2752:
2747:
2741:
2739:
2737:C-type lectins
2730:
2726:
2725:
2716:
2714:
2713:
2706:
2699:
2691:
2685:
2684:
2674:
2667:
2666:External links
2664:
2662:
2661:
2615:
2580:
2542:
2507:
2464:
2421:
2391:
2348:
2313:
2283:
2248:
2213:
2170:
2133:
2113:(10): 5981–7.
2098:
2069:
2034:
1991:
1971:(9): 1158–67.
1955:
1953:
1950:
1948:
1947:
1898:
1863:
1834:(3): 243–251.
1814:
1757:
1708:
1649:
1597:
1548:
1513:
1499:
1481:
1463:
1442:
1420:
1418:
1415:
1402:
1399:
1370:
1369:Skin disorders
1367:
1355:myofibroblasts
1338:
1337:Lung disorders
1335:
1295:
1292:
1276:
1273:
1248:
1245:
1230:
1227:
1218:
1215:
1193:
1190:
1147:
1144:
1096:
1095:
1092:
1091:
1086:
1076:
1075:
1069:
1068:
1065:
1064:
1062:
1060:
1053:
1052:
1045:
1038:
1034:
1033:
1030:
1029:
1021:
1020:
1014:
1011:
1010:
1006:NP_001119808.1
984:
983:
977:
973:
972:
969:
968:
942:
941:
935:
932:
931:
909:
908:
902:
898:
897:
894:
893:
885:
884:
878:
875:
874:
862:
861:
855:
849:
848:
845:
844:
836:
835:
829:
826:
825:
817:
816:
810:
804:
803:
800:
799:
791:
790:
784:
781:
780:
772:
771:
765:
759:
758:
753:
748:
744:
743:
733:
732:
729:
728:
717:
716:
714:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
647:
645:
641:
640:
638:
637:
632:
627:
622:
617:
612:
607:
602:
597:
591:
589:
585:
584:
582:
581:
576:
571:
566:
561:
556:
551:
545:
543:
539:
538:
528:
527:
524:
523:
520:
519:
511:
510:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
429:tail of embryo
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
383:saphenous vein
380:
376:
375:synovial joint
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3569:
3558:
3555:
3553:
3550:
3548:
3545:
3543:
3540:
3539:
3537:
3522:
3519:
3517:
3514:
3512:
3509:
3507:
3504:
3502:
3499:
3497:
3496:Thyroglobulin
3494:
3492:
3489:
3485:
3484:Glycophorin C
3482:
3480:
3477:
3475:
3472:
3471:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3367:
3366:
3364:
3360:
3350:
3347:
3346:
3344:
3342:
3338:
3332:
3329:
3327:
3324:
3322:
3319:
3318:
3316:
3314:
3310:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3265:
3262:
3261:
3259:
3257:
3253:
3247:
3244:
3242:
3239:
3238:
3236:
3234:
3230:
3226:
3220:
3217:
3215:
3212:
3210:
3207:
3206:
3204:
3202:
3198:
3194:
3191:
3189:
3188:Proteoglycans
3185:
3175:
3172:
3170:
3167:
3165:
3164:Peptidoglycan
3162:
3160:
3157:
3155:
3152:
3150:
3147:
3146:
3144:
3140:
3134:
3131:
3129:
3126:
3124:
3121:
3119:
3116:
3114:
3111:
3109:
3106:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3040:
3038:
3036:
3032:
3029:
3027:
3023:
3019:
3018:glycopeptides
3015:
3014:glycoproteins
3011:
3007:
3000:
2995:
2993:
2988:
2986:
2981:
2980:
2977:
2965:
2962:
2960:
2959:Legume lectin
2957:
2953:
2950:
2948:
2945:
2943:
2940:
2939:
2938:
2935:
2931:
2928:
2926:
2923:
2922:
2921:
2918:
2917:
2915:
2911:
2901:
2898:
2896:
2893:
2891:
2888:
2886:
2883:
2881:
2878:
2877:
2875:
2871:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2840:
2837:
2835:
2832:
2830:
2827:
2825:
2822:
2820:
2817:
2815:
2812:
2811:
2809:
2807:
2803:
2795:
2792:
2790:
2787:
2785:
2782:
2780:
2777:
2776:
2775:
2774:
2770:
2768:
2765:
2761:
2758:
2757:
2756:
2753:
2751:
2748:
2746:
2743:
2742:
2740:
2738:
2734:
2731:
2727:
2723:
2719:
2712:
2707:
2705:
2700:
2698:
2693:
2692:
2689:
2682:
2678:
2675:
2673:
2670:
2669:
2665:
2659:
2655:
2651:
2646:
2641:
2637:
2633:
2629:
2625:
2621:
2616:
2612:
2608:
2603:
2598:
2595:(7): 1630–9.
2594:
2590:
2586:
2581:
2577:
2573:
2569:
2565:
2561:
2557:
2554:(2): 219–26.
2553:
2549:
2543:
2539:
2535:
2530:
2525:
2521:
2517:
2513:
2508:
2504:
2500:
2496:
2492:
2487:
2482:
2478:
2474:
2473:J. Biol. Chem
2470:
2465:
2461:
2457:
2453:
2449:
2444:
2439:
2436:(4): 303–12.
2435:
2431:
2427:
2422:
2418:
2414:
2410:
2406:
2403:(3): 213–25.
2402:
2398:
2392:
2388:
2384:
2380:
2376:
2371:
2366:
2363:(8): 3914–8.
2362:
2358:
2357:J. Biol. Chem
2354:
2349:
2345:
2341:
2336:
2331:
2327:
2323:
2322:J. Biol. Chem
2319:
2314:
2310:
2306:
2302:
2298:
2294:
2290:
2284:
2280:
2276:
2271:
2266:
2262:
2258:
2257:J. Biol. Chem
2254:
2249:
2245:
2241:
2236:
2231:
2227:
2223:
2222:J. Biol. Chem
2219:
2214:
2210:
2206:
2201:
2196:
2192:
2188:
2184:
2180:
2176:
2171:
2167:
2163:
2159:
2155:
2151:
2147:
2143:
2139:
2134:
2130:
2126:
2121:
2116:
2112:
2108:
2107:J. Biol. Chem
2104:
2099:
2095:
2091:
2087:
2083:
2080:(4): 845–51.
2079:
2075:
2070:
2066:
2062:
2057:
2052:
2048:
2044:
2043:J. Biol. Chem
2040:
2035:
2031:
2027:
2022:
2017:
2013:
2009:
2006:(6): 209–15.
2005:
2001:
1997:
1992:
1988:
1984:
1979:
1974:
1970:
1966:
1962:
1957:
1956:
1951:
1943:
1939:
1935:
1931:
1926:
1921:
1917:
1913:
1912:J. Biol. Chem
1909:
1902:
1899:
1894:
1890:
1886:
1882:
1878:
1874:
1867:
1864:
1859:
1855:
1850:
1845:
1841:
1837:
1833:
1829:
1825:
1818:
1815:
1810:
1806:
1801:
1796:
1792:
1788:
1784:
1780:
1776:
1772:
1768:
1761:
1758:
1753:
1749:
1745:
1741:
1736:
1731:
1728:(5): 528–33.
1727:
1723:
1719:
1712:
1709:
1704:
1700:
1695:
1690:
1685:
1680:
1676:
1672:
1668:
1664:
1660:
1653:
1650:
1645:
1641:
1637:
1633:
1628:
1623:
1620:(3): 640–50.
1619:
1615:
1611:
1604:
1602:
1598:
1593:
1589:
1584:
1579:
1575:
1571:
1567:
1563:
1559:
1552:
1549:
1544:
1540:
1536:
1532:
1529:(4): 845–51.
1528:
1524:
1517:
1514:
1509:
1503:
1500:
1495:
1491:
1485:
1482:
1477:
1473:
1467:
1464:
1460:
1456:
1451:
1449:
1447:
1443:
1439:
1435:
1430:
1428:
1426:
1422:
1416:
1414:
1412:
1408:
1400:
1398:
1396:
1392:
1388:
1384:
1380:
1376:
1368:
1366:
1364:
1360:
1356:
1352:
1348:
1344:
1336:
1334:
1332:
1328:
1327:myeloid cells
1324:
1320:
1315:
1313:
1309:
1305:
1301:
1293:
1291:
1289:
1284:
1282:
1274:
1272:
1270:
1266:
1262:
1258:
1254:
1246:
1244:
1241:
1235:
1228:
1226:
1224:
1216:
1214:
1212:
1206:
1204:
1199:
1198:proliferation
1191:
1189:
1187:
1182:
1178:
1176:
1172:
1167:
1165:
1161:
1157:
1153:
1145:
1143:
1141:
1137:
1133:
1130:(abundant in
1129:
1125:
1120:
1117:
1112:
1110:
1106:
1102:
1090:
1085:
1081:
1077:
1074:
1070:
1063:
1061:
1058:
1054:
1050:
1046:
1043:
1039:
1035:
1028:
1022:
1018:
1015:
1009:
1007:
1003:
999:
995:
991:
985:
981:
978:
974:
967:
965:
961:
957:
953:
949:
943:
939:
936:
930:
928:
924:
920:
916:
910:
906:
903:
901:RefSeq (mRNA)
899:
892:
891:
886:
882:
879:
873:
872:
868:
863:
859:
856:
854:
850:
843:
842:
837:
833:
830:
824:
823:
818:
814:
811:
809:
805:
798:
797:
792:
788:
785:
779:
778:
773:
769:
766:
764:
760:
757:
754:
752:
749:
745:
742:
738:
734:
727:
723:
718:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
686:cell adhesion
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
648:
646:
643:
642:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
592:
590:
587:
586:
580:
577:
575:
572:
570:
567:
565:
562:
560:
557:
555:
552:
550:
547:
546:
544:
541:
540:
537:
536:Gene ontology
533:
529:
517:
512:
508:
501:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
3409:4-1BB ligand
3321:Fibromodulin
3218:
3026:Mucoproteins
2885:Calreticulin
2814:Sialoadhesin
2783:
2771:
2657:
2627:
2623:
2592:
2588:
2551:
2547:
2519:
2515:
2476:
2472:
2433:
2429:
2400:
2396:
2360:
2356:
2325:
2321:
2295:(5): 671–5.
2292:
2288:
2260:
2256:
2225:
2221:
2182:
2178:
2144:(1): 67–70.
2141:
2137:
2110:
2106:
2077:
2073:
2046:
2042:
2003:
1999:
1968:
1964:
1915:
1911:
1901:
1876:
1872:
1866:
1831:
1828:Glycobiology
1827:
1817:
1774:
1770:
1760:
1725:
1721:
1711:
1666:
1662:
1652:
1617:
1613:
1565:
1561:
1551:
1526:
1522:
1516:
1502:
1493:
1484:
1475:
1466:
1404:
1401:Interactions
1372:
1340:
1329:and produce
1325:to activate
1316:
1297:
1285:
1278:
1268:
1256:
1250:
1236:
1232:
1220:
1211:neural crest
1207:
1195:
1183:
1179:
1168:
1149:
1121:
1113:
1108:
1105:proteoglycan
1100:
1099:
1024:
998:NP_001157570
994:NP_001157569
990:NP_001119808
987:
956:NM_001134475
952:NM_001134474
948:NM_001081249
945:
927:NM_001164098
923:NM_001164097
919:NM_001126336
912:
888:
865:
839:
820:
794:
775:
755:
750:
433:cumulus cell
425:vas deferens
333:
326:
170:5q14.2-q14.3
53:External IDs
3521:Vitronectin
3516:Uteroglobin
3506:Transcortin
3479:Glycophorin
3449:Osteonectin
3434:Lactoferrin
3159:Orosomucoid
3149:Haptoglobin
2920:Toxalbumins
2630:: 494–504.
2397:Matrix Biol
1359:macrophages
610:Golgi lumen
363:pericardium
292:89,890,628
279:89,803,431
191:83,582,303
178:83,471,618
31:Identifiers
3536:Categories
3349:Syndecan 1
1461:, May 2017
1440:, May 2017
1417:References
1281:chemokines
1247:C-terminus
1217:N-terminus
1175:Hyaluronan
1160:C-terminal
1156:N-terminal
1152:homologous
337:(ortholog)
74:HomoloGene
3547:Lecticans
3459:Protein S
3454:Protein C
3429:Hemopexin
3419:Clusterin
3331:Keratocan
2755:Collectin
2677:Versicans
1965:Circ. Res
1331:TNF-alpha
1265:fibulin-2
1203:integrins
1154:globular
1146:Structure
1132:cartilage
1002:NP_004376
964:NM_172955
960:NM_019389
915:NM_004385
741:Orthologs
82:GeneCards
3278:Brevican
3273:Neurocan
3268:Aggrecan
3246:Perlecan
3241:Testican
3219:Versican
3214:Biglycan
3174:Ovomucin
2937:Mitogens
2900:Selectin
2890:Galectin
2880:Calnexin
2864:SIGLEC12
2859:SIGLEC10
2794:Neurocan
2789:Brevican
2784:Versican
2779:Aggrecan
2654:31051334
2611:10397680
2576:43814139
2568:10198161
2548:Genomics
2503:21537718
2460:23190687
2387:26136117
2166:25745740
2074:Genomics
2030:16839865
1987:15142969
1942:45915209
1934:12888576
1893:25900252
1858:25371494
1809:19122641
1752:24838751
1644:36289786
1636:19662655
1523:Genomics
1457:–
1436:–
1407:interact
1349:(COPD),
1314:cancer.
1300:melanoma
1261:syndecan
1253:tenascin
1192:Function
1140:neurocan
1136:brevican
1128:aggrecan
1124:lectican
1101:Versican
1073:Wikidata
720:Sources:
595:membrane
359:monocyte
3326:Lumican
3209:Decorin
3006:Protein
2854:SIGLEC9
2849:SIGLEC8
2844:SIGLEC7
2839:SIGLEC6
2834:SIGLEC5
2722:lectins
2718:Protein
2645:6495079
2538:9848887
2495:8824283
2452:8601689
2417:7921538
2379:7876137
2344:7806529
2309:7748141
2279:7528742
2244:2820964
2209:2583089
2158:2469524
2129:2466833
2094:1478664
2065:1429726
2021:3169384
1849:4310351
1800:2746432
1779:Bibcode
1744:8627343
1703:9294172
1671:Bibcode
1592:2583089
1543:1478664
1459:Ensembl
1438:Ensembl
1381:during
1304:sarcoma
1269:in vivo
1257:in vivo
853:UniProt
808:Ensembl
747:Species
726:QuickGO
312:pattern
38:Aliases
3399:Avidin
3078:MUC5AC
2964:BanLec
2806:SIGLEC
2729:Animal
2683:(MeSH)
2652:
2642:
2609:
2574:
2566:
2536:
2501:
2493:
2458:
2450:
2415:
2385:
2377:
2342:
2307:
2277:
2242:
2207:
2200:401368
2197:
2179:EMBO J
2164:
2156:
2127:
2092:
2063:
2028:
2018:
1985:
1940:
1932:
1891:
1856:
1846:
1807:
1797:
1771:Nature
1750:
1742:
1701:
1691:
1642:
1634:
1590:
1583:401368
1580:
1562:EMBO J
1541:
1411:HAPLN1
1383:keloid
1351:asthma
1312:breast
1306:, and
1162:, and
1111:gene.
1059:search
1057:PubMed
890:Q62059
871:Q86W61
867:P13611
763:Entrez
483:BioGPS
453:dermis
70:102889
62:118661
3362:Other
3293:CSPG5
3288:CSPG4
3142:Other
3133:MUC20
3128:MUC19
3123:MUC17
3118:MUC16
3113:MUC15
3108:MUC13
3103:MUC12
3083:MUC5B
3068:MUC3B
3063:MUC3A
3048:CD164
3035:Mucin
2930:Ricin
2925:Abrin
2913:Plant
2873:Other
2750:KLRD1
2572:S2CID
2499:S2CID
2456:S2CID
2383:S2CID
2162:S2CID
1938:S2CID
1748:S2CID
1694:23322
1640:S2CID
1395:wound
796:13003
756:Mouse
751:Human
722:Amigo
457:molar
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
3474:CD43
3389:CD70
3374:ADAM
3283:CD44
3098:MUC8
3093:MUC7
3088:MUC6
3073:MUC4
3058:MUC2
3053:MUC1
3043:CD43
3016:and
2824:CD33
2819:CD22
2650:PMID
2607:PMID
2564:PMID
2534:PMID
2491:PMID
2448:PMID
2413:PMID
2375:PMID
2340:PMID
2305:PMID
2275:PMID
2240:PMID
2205:PMID
2154:PMID
2125:PMID
2090:PMID
2061:PMID
2026:PMID
1983:PMID
1930:PMID
1889:PMID
1854:PMID
1805:PMID
1740:PMID
1699:PMID
1632:PMID
1588:PMID
1539:PMID
1391:skin
1387:scar
1375:skin
1323:TLR2
1138:and
1109:VCAN
777:1462
449:hand
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
86:VCAN
78:3228
58:OMIM
45:VCAN
22:VCAN
2640:PMC
2632:doi
2597:doi
2556:doi
2524:doi
2481:doi
2477:271
2438:doi
2405:doi
2365:doi
2361:270
2330:doi
2326:269
2297:doi
2293:113
2265:doi
2261:269
2230:doi
2226:262
2195:PMC
2187:doi
2146:doi
2115:doi
2111:264
2082:doi
2051:doi
2047:267
2016:PMC
2008:doi
1973:doi
1920:doi
1916:278
1881:doi
1844:PMC
1836:doi
1795:PMC
1787:doi
1775:457
1730:doi
1689:PMC
1679:doi
1622:doi
1618:126
1578:PMC
1570:doi
1531:doi
1413:).
1223:ECM
1134:),
1026:n/a
288:End
187:End
90:OMA
66:MGI
3538::
3341:HS
3313:KS
3266::
3256:CS
3233:CS
3229:HS
3201:DS
3197:CS
3012::
3008:,
2720::
2656:.
2648:.
2638:.
2628:16
2626:.
2622:.
2605:.
2593:19
2591:.
2587:.
2570:.
2562:.
2552:57
2550:.
2532:.
2520:18
2518:.
2514:.
2497:.
2489:.
2475:.
2471:.
2454:.
2446:.
2434:44
2432:.
2428:.
2411:.
2401:14
2399:.
2381:.
2373:.
2359:.
2355:.
2338:.
2324:.
2320:.
2303:.
2291:.
2273:.
2259:.
2255:.
2238:.
2224:.
2220:.
2203:.
2193:.
2181:.
2177:.
2160:.
2152:.
2142:22
2140:.
2123:.
2109:.
2105:.
2088:.
2078:14
2076:.
2059:.
2045:.
2041:.
2024:.
2014:.
2004:16
2002:.
1998:.
1981:.
1969:94
1967:.
1963:.
1936:.
1928:.
1914:.
1910:.
1887:.
1877:30
1875:.
1852:.
1842:.
1832:25
1830:.
1826:.
1803:.
1793:.
1785:.
1773:.
1769:.
1746:.
1738:.
1726:55
1724:.
1720:.
1697:.
1687:.
1677:.
1667:94
1665:.
1661:.
1638:.
1630:.
1616:.
1612:.
1600:^
1586:.
1576:.
1564:.
1560:.
1537:.
1527:14
1525:.
1492:.
1474:.
1445:^
1424:^
1397:.
1357:,
1333:.
1302:,
1271:.
1171:Ig
1158:,
724:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
3231:/
3199:/
2998:e
2991:t
2984:v
2710:e
2703:t
2696:v
2634::
2613:.
2599::
2578:.
2558::
2540:.
2526::
2505:.
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2440::
2419:.
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2346:.
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2168:.
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2131:.
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2096:.
2084::
2067:.
2053::
2032:.
2010::
1989:.
1975::
1944:.
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1860:.
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1732::
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1646:.
1624::
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1545:.
1533::
1510:.
1496:.
1478:.
212:)
109:)
92::
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