222:, an adhesion molecule and component of extracellular matrices, and he subsequently identified and cloned a number of other extracellular matrix components and adhesion molecules. In 1984, he identified the sequence within fibronectin that mediates cell attachment, called RGD for the amino acids of which it’s composed, and isolated the cellular receptors that bind that sequence, now known as integrins. The RGD discovery has led to the development of drugs for vascular thrombosis and cancer, among other diseases.
286:, is in clinical trials in solid tumor patients tested as an enhancer of cancer therapies. This peptide recognizes many different types of cancers, and it can be used for tumor delivery of various payloads that are either coupled to the peptide, or given together with it. iRGD has also been shown to effectively deliver drugs to the placenta, which could aid in the treatment of slow fetal growth.
39:
427:
274:
Ruoslahti's research group has developed a novel class of tumor-homing peptides that can be used to enhance delivery of drugs and nanoparticles to tumors. These tumor-penetrating peptides selectively home to tumor vessels, where they activate a transport pathway that delivers the peptide, and along
225:
Ruoslahti currently studies specific marker molecules in blood vessels. He introduced the concept of vascular "zip codes," the idea that each tissue bears molecular signatures that can be targeted by affinity ligands, and used in vivo peptide phage display to prove the concept and develop numerous
2077:
275:
with it drugs and even nanoparticles, through the wall of tumor blood vessels and deep into tumor tissue. Having bound to tumor vessels the peptide is cleaved and an amino acid sequence motif named the C-end rule or
2057:
299:
96:
279:
motif (pronounced "sender") is exposed at the C-terminus of the peptide. Subsequent binding of the peptide to neuropilin-1 activates the CendR transport pathway into and through tumor tissue.
1330:
Mann, AP; Scodeller, P; Hussain, S; Joo, J; Kwon, E; Braun, GB; Mölder, T; She, Z; Kotamraju, VR; Ranscht, B; Krajewski, S; Teesalu, T; Bhatia, S; Sailor, MJ; Ruoslahti, E (2016).
2072:
259:
212:
185:
2062:
312:
1295:
She, ZG; Hamzah, J; Kotamraju, VR; Pang, HB; Jansen, S; Ruoslahti, E (2016). "Plaque-penetrating peptide inhibits development of hypoxic atherosclerotic plaque".
379:
1053:
955:
1189:
King, A; Ndifon, C; Lui, S; Widdows, K; Kotamraju, VR; Agemy, L; Teesalu, T; Glazier, JD; Cellesi, F; Tirelli, N; Aplin, JD; Ruoslahti, E; Harris, LK (2016).
289:
Recently, in vivo phage screening has been used to identify peptides that target hypertensive pulmonary arteries, atherosclerosis, and diseases of the brain.
234:
Ruoslahti received his M.D. from the
University of Helsinki in 1965 and his Ph.D. from the same institution in 1967. He completed postdoctoral studies at
386:
305:
103:
900:"Neuropilin-1 and heparan sulfate proteoglycans cooperate in cellular uptake of nanoparticles functionalized by cationic cell-penetrating peptides"
538:
Pierschbacher, MD; Ruoslahti, E (1984). "Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule".
410:
336:
263:
116:
2047:
1451:
792:
Sugahara, K. N.; Teesalu, T.; Karmali, P. P.; Kotamraju, V. R.; Agemy, L.; Girard, O. M.; Hanahan, D.; Mattrey, R. F.; Ruoslahti, E. (2009).
405:
1485:
255:
180:
367:
361:
170:
969:
1604:
342:
138:
1795:
309:
1248:"A Novel Vascular Homing Peptide Strategy to Selectively Enhance Pulmonary Drug Efficacy in Pulmonary Arterial Hypertension"
218:
Ruoslahti made seminal contributions to biology of extracellular matrix and its receptors. He was one of the discoverers of
1588:
1386:
400:
395:
373:
1983:
1564:
1398:
1061:
995:
Sugahara, K. N.; Teesalu, T.; Karmali, P. P.; Kotamraju, V. R.; Agemy, L.; Greenwald, D. R.; Ruoslahti, E. (2010).
1767:
1479:
1246:
Toba, M; Alzoubi, A; O’Neill, K; Abe, ohtaro; Urakami, T; Komatsu, M; Alvarez, D; Järvinen, TAH; Mann, D (2014).
1975:
1444:
1771:
1747:
956:"Compound discovered at Sanford Burnham Prebys advances into Phase 1 trial for pancreatic cancer | SBP"
442:
2052:
1916:
1535:
1332:"A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries"
841:
Pang, HB; Braun, GB; Friman, T; Aza-Blanc, P; Ruidiaz, ME; Sugahara, KN; Teesalu, T; Ruoslahti, E (2014).
247:
483:
Closing In on Cancer : In Search of a Cure, a La Jolla
Research Center Reaches Into the Outer Limits
262:, or SBP) in 1979. He served as SBP's president from 1989-2002, and was a distinguished professor at the
329:
110:
482:
2067:
2021:
1437:
1343:
1202:
1145:
1008:
911:
854:
743:
547:
504:
1886:
1844:
1574:
348:
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175:
126:
1965:
1910:
1896:
1799:
1757:
1705:
1701:
1695:
1670:
1666:
1646:
1642:
1618:
1411:
571:
2007:
1969:
495:
Ruoslahti, E; Pierschbacher, MD (1987). "New perspectives in cell adhesion: RGD and integrins".
1083:
Agemy, L; Kotamraju, VR; Friedmann-Morvinski, D; Sharma, S; Sugahara, KN; Ruoslahti, E (2013).
2003:
1997:
1989:
1882:
1826:
1785:
1781:
1725:
1719:
1539:
1369:
1312:
1277:
1228:
1171:
1114:
1034:
937:
880:
843:"An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability"
823:
771:
712:
704:
669:
620:
563:
520:
1872:
1660:
1634:
1568:
1513:
1509:
1359:
1351:
1304:
1267:
1259:
1218:
1210:
1161:
1153:
1104:
1096:
1024:
1016:
973:
927:
919:
870:
862:
813:
805:
761:
751:
696:
659:
651:
610:
602:
555:
512:
732:"C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration"
461:
2025:
2011:
1979:
1934:
1920:
1892:
1743:
1711:
1674:
1560:
1503:
1489:
322:
316:
1876:
591:"A cell surface receptor complex for collagen type I recognizes the Arg-Gly-Asp sequence"
1347:
1206:
1149:
1012:
915:
858:
747:
551:
508:
432:
1944:
1938:
1862:
1840:
1830:
1805:
1729:
1624:
1608:
1598:
1525:
1495:
1475:
1364:
1331:
1272:
1247:
1223:
1190:
1166:
1133:
1109:
1084:
1029:
997:"Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs"
996:
932:
899:
875:
842:
818:
793:
766:
731:
664:
639:
615:
590:
2041:
2017:
1993:
1930:
1900:
1866:
1848:
1809:
1739:
1614:
1556:
1906:
1858:
1854:
1836:
1753:
1715:
1656:
1584:
1578:
1529:
1521:
1499:
575:
1308:
1191:"Tumor-homing peptides as tools for targeted delivery of payloads to the placenta"
1263:
1157:
258:
in Duarte, California until joining the La Jolla Cancer
Research Foundation (now
1777:
1733:
1594:
1460:
354:
219:
132:
1132:
Sharma, S; Kotamraju, VR; Mölder, T; Tobi, A; Teesalu, T; Ruoslahti, E (2017).
1948:
1924:
1691:
1638:
1517:
809:
38:
708:
1791:
1652:
1628:
1020:
756:
516:
1373:
1316:
1281:
1232:
1214:
1175:
1118:
1085:"Proapoptotic Peptide-Mediated Cancer Therapy Targeted to Cell Surface p32"
1038:
941:
923:
884:
827:
775:
716:
687:
Ruoslahti, E. (2004). "Vascular zip codes in angiogenesis and metastasis".
673:
640:"Integrin-based therapeutics: biological basis, clinical use and new drugs"
624:
606:
567:
524:
1429:
17:
1355:
1100:
794:"Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors"
655:
866:
700:
235:
208:
1134:"Tumor-Penetrating Nanosystem Strongly Suppresses Breast Tumor Growth"
730:
Teesalu, T.; Sugahara, K. N.; Kotamraju, V. R.; Ruoslahti, E. (2009).
559:
204:
276:
2078:
Recipients of the Albert Lasker Award for Basic
Medical Research
283:
1433:
300:
Robert J. and Claire
Pasarow Foundation Medical Research Award
97:
Robert J. and Claire
Pasarow Foundation Medical Research Award
638:
Ley, K; Rivera-Nieves, J; Sandborn, WJ; Shattil, S (2016).
159:
Cancer, Tumor biology, Vascular biology, Neurodegeneration
2058:
Members of the United States
National Academy of Sciences
211:) is a cancer researcher and distinguished professor at
246:
Ruoslahti held various academic appointments with the
215:. He moved from Finland to the United States in 1976.
464:. Sanford Burnham Prebys Medical Discovery Institute
1958:
1819:
1684:
1549:
1468:
589:Dedhar, S; Ruoslahti, E; Pierschbacher, MD (1987).
163:
155:
91:
83:
75:
67:
45:
29:
1054:"New Peptide Helps Cancer Drugs Break Into Tumors"
970:"Cancer Drug Effectiveness Substantially Advanced"
260:Sanford Burnham Prebys Medical Discovery Institute
213:Sanford Burnham Prebys Medical Discovery Institute
186:Sanford Burnham Prebys Medical Discovery Institute
270:Recent work on homing peptides and nanomedicine
1387:Albert Lasker Award for Basic Medical Research
380:Albert Lasker Award for Basic Medical Research
1445:
8:
1414:. United States National Academy of Sciences
2073:Members of the National Academy of Medicine
321:1991 - Honorary doctorate in medicine from
1452:
1438:
1430:
898:Pang, HB; Braun, GB; Ruoslahti, E (2015).
787:
785:
37:
26:
1363:
1271:
1222:
1165:
1108:
1052:Couzin-Frankel, Jennifer (8 April 2010).
1028:
931:
874:
817:
765:
755:
663:
614:
282:The prototype tumor-penetrating peptide,
2063:Finnish expatriates in the United States
387:American Association for Cancer Research
306:American Association for Cancer Research
104:American Association for Cancer Research
453:
411:European Molecular Biology Organization
337:Gairdner Foundation International Award
264:University of California, Santa Barbara
117:Gairdner Foundation International Award
87:Work on cell adhesion and nanomedicine
1399:AACR Academy Fellows: Erkki Ruoslahti
406:American Academy of Arts and Sciences
7:
256:City of Hope National Medical Center
181:City of Hope National Medical Center
122:Jacobaeus International Prize (1998)
368:Order of the White Rose of Finland
171:California Institute of Technology
25:
362:Thomson Reuters Citation Laureate
139:Thomson Reuters Citation Laureate
425:
1879:/ John Frederick Grassle (2013)
79:University of Helsinki, Finland
102:G.H.A. Clowes Memorial Award,
1:
1589:Ernest John Christopher Polge
1309:10.1016/j.jconrel.2016.07.020
343:Jacobaeus International Prize
2048:American medical researchers
1264:10.1016/j.ajpath.2013.10.008
1158:10.1021/acs.nanolett.6b03815
401:National Academy of Medicine
396:National Academy of Sciences
374:Order of the Lion of Finland
310:G.H.A. Clowes Memorial Award
328:1995 - Nobel Fellow at the
2094:
203:(born 16 February 1940 in
1605:William Hayward Pickering
1480:Ephraim Katchalski-Katzir
810:10.1016/j.ccr.2009.10.013
347:2003 - Jubilee Lecturer,
194:
148:
36:
1746:/ Keith J. Sainsbury /
1021:10.1126/science.1183057
757:10.1073/pnas.0908201106
517:10.1126/science.2821619
226:tumor-homing peptides.
1917:Emmanuelle Charpentier
1536:Frank Sherwood Rowland
1215:10.1126/sciadv.1600349
924:10.1126/sciadv.1500821
736:Proc Natl Acad Sci USA
248:University of Helsinki
607:10.1083/jcb.104.3.585
385:2023 - Fellow of the
330:Karolinska Institutet
111:Karolinska Institutet
2022:John Michael Wallace
135:(Cell Biology, 2005)
109:Nobel Fellow at the
2006:/ Kazuo Hagimoto /
1845:Tadamitsu Kishimoto
1575:Jacques-Louis Lions
1356:10.1038/ncomms11980
1348:2016NatCo...711980M
1207:2016SciA....2E0349K
1150:2017NanoL..17.1356S
1101:10.1038/mt.2013.191
1013:2010Sci...328.1031S
1007:(5981): 1031–1035.
916:2015SciA....1E0821P
859:2014NatCo...5.4904P
748:2009PNAS..10616157T
742:(38): 16157–16162.
656:10.1038/nrd.2015.10
644:Nat Rev Drug Discov
552:1984Natur.309...30P
509:1987Sci...238..491R
349:Biochemical Society
252:University of Turku
176:University of Turku
127:Biochemical Society
1984:Robert A. Weinberg
1966:Robert G. Gallager
1911:Steven D. Tanksley
1897:Theodore Friedmann
1800:Victor A. McKusick
1758:Masatoshi Takeichi
1706:Timothy R. Parsons
1702:John B. Goodenough
1696:Kimishige Ishizaka
1671:Jack L. Strominger
1667:W. Wesley Peterson
1647:Hiroyuki Yoshikawa
1643:Joseph Engelberger
1619:Edward F. Knipling
867:10.1038/ncomms5904
701:10.1042/bst0320397
315:2017-10-24 at the
125:Jubilee Lecturer,
113:, Stockholm (1995)
2035:
2034:
2004:Masataka Nakazawa
1998:Christopher Field
1883:Yasuharu Suematsu
1827:Shun-ichi Iwasaki
1786:Peter Shaw Ashton
1726:Benoit Mandelbrot
1720:Andrzej Tarkowski
1540:Elias James Corey
1412:"Erkki Ruoslahti"
1297:J Control Release
1095:(12): 2195–2204.
689:Biochem Soc Trans
503:(4826): 491–497.
485:Los Angeles Times
462:"Erkki Ruoslahti"
372:Commander of the
293:Awards and honors
198:
197:
150:Scientific career
16:(Redirected from
2085:
1873:C. Grant Willson
1661:Marc Van Montagu
1635:Takashi Sugimura
1569:Xavier Le Pichon
1514:Donald Henderson
1510:Georges Vendryes
1454:
1447:
1440:
1431:
1424:
1423:
1421:
1419:
1408:
1402:
1396:
1390:
1384:
1378:
1377:
1367:
1327:
1321:
1320:
1292:
1286:
1285:
1275:
1243:
1237:
1236:
1226:
1186:
1180:
1179:
1169:
1144:(3): 1356–1364.
1129:
1123:
1122:
1112:
1080:
1074:
1073:
1071:
1069:
1060:. Archived from
1049:
1043:
1042:
1032:
992:
986:
985:
983:
981:
972:. Archived from
966:
960:
959:
952:
946:
945:
935:
910:(10): e1500821.
895:
889:
888:
878:
838:
832:
831:
821:
789:
780:
779:
769:
759:
727:
721:
720:
684:
678:
677:
667:
635:
629:
628:
618:
586:
580:
579:
560:10.1038/309030a0
535:
529:
528:
492:
486:
480:
474:
473:
471:
469:
458:
429:
428:
266:from 2005-2015.
59:
56:16 February 1940
55:
53:
41:
27:
21:
2093:
2092:
2088:
2087:
2086:
2084:
2083:
2082:
2038:
2037:
2036:
2031:
2026:Ronald M. Evans
2012:Karl Deisseroth
2008:Gero Miesenböck
1980:Bert Vogelstein
1976:Martin A. Green
1954:
1935:Max Dale Cooper
1921:Jennifer Doudna
1893:Yutaka Takahasi
1815:
1762:Erkki Ruoslahti
1744:Akira Fujishima
1712:Tim Berners-Lee
1680:
1675:Don Craig Wiley
1561:W. Jason Morgan
1545:
1504:Theodore Maiman
1490:Willem J. Kolff
1464:
1458:
1428:
1427:
1417:
1415:
1410:
1409:
1405:
1397:
1393:
1385:
1381:
1329:
1328:
1324:
1294:
1293:
1289:
1245:
1244:
1240:
1201:(5): e1600349.
1188:
1187:
1183:
1131:
1130:
1126:
1082:
1081:
1077:
1067:
1065:
1064:on June 8, 2013
1051:
1050:
1046:
994:
993:
989:
979:
977:
968:
967:
963:
954:
953:
949:
897:
896:
892:
840:
839:
835:
791:
790:
783:
729:
728:
724:
686:
685:
681:
637:
636:
632:
588:
587:
583:
546:(5963): 30–33.
537:
536:
532:
494:
493:
489:
481:
477:
467:
465:
460:
459:
455:
450:
449:
448:
443:Erkki Ruoslahti
430:
426:
421:
357:in Cell Biology
323:Lund University
317:Wayback Machine
295:
272:
254:in Finland and
244:
232:
201:Erkki Ruoslahti
190:
144:
99:(Cancer, 1990)
76:Alma mater
63:
62:Imatra, Finland
60:
57:
51:
49:
32:
31:Erkki Ruoslahti
23:
22:
15:
12:
11:
5:
2091:
2089:
2081:
2080:
2075:
2070:
2065:
2060:
2055:
2050:
2040:
2039:
2033:
2032:
2030:
2029:
2015:
2001:
1990:Katalin KarikĂł
1987:
1973:
1962:
1960:
1956:
1955:
1953:
1952:
1945:Yoshio Okamoto
1942:
1939:Jacques Miller
1928:
1914:
1904:
1890:
1887:C. David Allis
1880:
1870:
1863:Nicholas Lydon
1852:
1841:Dennis Ritchie
1834:
1831:Peter Vitousek
1823:
1821:
1817:
1816:
1814:
1813:
1806:Dennis Meadows
1803:
1796:Robert E. Kahn
1789:
1782:Peter GrĂĽnberg
1775:
1765:
1751:
1748:John H. Lawton
1737:
1730:James A. Yorke
1723:
1709:
1699:
1688:
1686:
1682:
1681:
1679:
1678:
1664:
1650:
1632:
1625:Charles K. Kao
1622:
1612:
1609:Arvid Carlsson
1602:
1599:Kary B. Mullis
1592:
1582:
1572:
1553:
1551:
1547:
1546:
1544:
1543:
1533:
1526:Luc Montagnier
1507:
1496:Henry Beachell
1493:
1486:David Turnbull
1483:
1476:John R. Pierce
1472:
1470:
1466:
1465:
1459:
1457:
1456:
1449:
1442:
1434:
1426:
1425:
1403:
1391:
1379:
1322:
1287:
1258:(2): 369–375.
1238:
1181:
1124:
1075:
1044:
987:
976:on May 7, 2010
961:
947:
890:
853:: ncomms5904.
833:
804:(6): 510–520.
781:
722:
695:(3): 397–402.
679:
650:(3): 173–183.
630:
601:(3): 585–593.
581:
530:
487:
475:
452:
451:
431:
424:
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422:
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366:Knight of the
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84:Known for
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69:
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61:
47:
43:
42:
34:
33:
30:
24:
14:
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4:
3:
2:
2090:
2079:
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2066:
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2061:
2059:
2056:
2054:
2053:Living people
2051:
2049:
2046:
2045:
2043:
2027:
2023:
2019:
2018:Brian Hoskins
2016:
2013:
2009:
2005:
2002:
1999:
1995:
1994:Drew Weissman
1991:
1988:
1985:
1981:
1977:
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1971:
1967:
1964:
1963:
1961:
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1946:
1943:
1940:
1936:
1932:
1931:Akira Yoshino
1929:
1926:
1922:
1918:
1915:
1912:
1908:
1905:
1902:
1901:Alain Fischer
1898:
1894:
1891:
1888:
1884:
1881:
1878:
1874:
1871:
1868:
1867:Masato Sagawa
1864:
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1856:
1853:
1850:
1849:Toshio Hirano
1846:
1842:
1838:
1835:
1832:
1828:
1825:
1824:
1822:
1818:
1811:
1810:David E. Kuhl
1807:
1804:
1801:
1797:
1793:
1790:
1787:
1783:
1779:
1776:
1773:
1769:
1768:John Houghton
1766:
1763:
1759:
1755:
1752:
1749:
1745:
1741:
1740:Kenichi Honda
1738:
1735:
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1859:Brian Druker
1855:Janet Rowley
1837:Ken Thompson
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1716:Anne McLaren
1657:Jozef Schell
1585:Gerhard Ertl
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1565:Dan McKenzie
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1778:Albert Fert
1734:Seiji Ogawa
1595:Frank Press
1461:Japan Prize
1303:: 212–220.
1252:Am J Pathol
798:Cancer Cell
595:J Cell Biol
468:October 30,
355:Japan Prize
220:fibronectin
133:Japan Prize
71:US, Finland
68:Nationality
2042:Categories
1949:Rattan Lal
1925:Adi Shamir
1772:Akira Endo
1692:Ian McHarg
1639:Bruce Ames
1518:Isao Arita
1463:recipients
1336:Nat Commun
1058:ScienceNOW
847:Nat Commun
419:References
392:Member of
52:1940-02-16
1792:Vint Cerf
1653:Leo Esaki
1629:Masao Ito
1342:: 11980.
1138:Nano Lett
1068:March 14,
980:April 17,
709:0300-5127
230:Education
18:Ruoslahti
1418:14 March
1374:27351915
1317:27423327
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1089:Mol Ther
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776:19805273
717:15157146
674:26822833
325:, Sweden
313:Archived
250:and the
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1344:Bibcode
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1224:4928982
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1195:Sci Adv
1167:5819594
1146:Bibcode
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1030:2881692
1009:Bibcode
1001:Science
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912:Bibcode
904:Sci Adv
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855:Bibcode
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744:Bibcode
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548:Bibcode
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