1407:
characterized by the interaction between its head and tail domains. And, when transforming to the ‘active’ form, such as when talin triggers binding, the intramolecular interaction between the tail and head is severed. In other words, when talin's binding sites (VBS) of α-helices bind to a helical bundle structure in vinculin's head domain, the ‘helical bundle conversion’ is initiated, which leads to the reorganization of the α-helices (α1- α-4), resulting in an entirely new five-helical bundle structure. This function also extends to cancer cells, and regulating their movement and proliferation of cancer to other parts of the body.
392:
369:
1311:
3642:
3627:
266:
3552:
291:
3432:
3477:
3537:
3522:
3447:
3597:
3582:
3567:
3417:
3507:
650:
643:
398:
297:
3492:
3612:
3462:
35:
1750:. Metavinculin tail domain has a lower affinity for the head as compared with the vinculin tail. In case of metavinculin, unfurling of the C-terminal hydrophobic hairpin loop of tail domain is impaired by the negative charges of the 68-amino acid insert, thus requiring phospholipid-activated regular isoform of vinculin to fully activate the metavinculin molecule.
1523:
1722:(meta VCL) of ~150KD molecular weight — a protein whose existence has been known since the 1980s. Translation of the extra exon causes a 68- to 79-amino acid acid-rich insert between helices I and II within the C-terminal tail domain. Mutations within the insert region correlate with hereditary idiopathic dilated
2614:
Pimentel M, Morales W, Pokkunuri V, Brikos C, Kim SM, Kim SE, Triantafyllou K, Weitsman S, Marsh Z, Marsh E, Chua KS, Srinivasan S, Barlow GM, Chang C (May 2015). "Autoimmunity Links
Vinculin to the Pathophysiology of Chronic Functional Bowel Changes Following Campylobacter jejuni Infection in a Rat
1459:
and lamellipodia that were less stable than the wild-type. Based on research, it has been postulated that the lack of vinculin may decrease cell adhesion by inhibiting focal adhesion assembly and preventing actin polymerization. On the other hand, overexpression of vinculin may restore adhesion and
1450:
The loss of vinculin impacts a variety of cell functions; it disrupts the formation of the complex, and prevents cell adhesion and spreading. The absence of the protein demonstrates a decrease in spreading of cells, accompanied by reduced stress fiber formation, formation of fewer focal adhesions,
1406:
The recent discovery of the 3D structure sheds light on how this protein tailors its shape to perform a variety of functions. For example, vinculin is able to control the cell's motility by simply altering its shape from active to inactive. When in its ‘inactive’ state, vinculin's conformation is
1446:
In more specific terms, the amino-terminus of vinculin binds to talin, which, in turn, binds to β-integrins, and the carboxy-terminus binds to actin, phospholipids, and paxillin-forming homodimers. The binding of vinculin to talin and actin is regulated by polyphosphoinositides and inhibited by
1359:
Binding alternately to talin or α-actinin, vinculin's shape and, as a consequence, its binding properties are changed. The vinculin gene occurs as a single copy and what appears to be no close relative to take over functions in its absence. Its splice variant metavinculin (see below) also needs
1729:
The length of the insert in metavinculin is 68 AA in mammals and 79 in frog. Compared metavinculin sequences from pig, man, chicken, and frog, and found the insert to be bipartite: the first part variable and the second highly conserved. Both vinculin isoforms co-localize in muscular adhesive
1464:
to the cytoskeleton at the focal adhesion appears to be critical for control of cytoskeletal mechanics, cell spreading, and lamellipodia formation. Thus, vinculin appears to play a key role in shape control based on its ability to modulate focal adhesion structure and function.
61:
3641:
3626:
3551:
3476:
2128:
Gingras AR, Vogel KP, Steinhoff HJ, Ziegler WH, Patel B, Emsley J, Critchley DR, Roberts GC, Barsukov IL (February 2006). "Structural and dynamic characterization of a vinculin binding site in the talin rod".
2693:"An additional exon in the human vinculin gene specifically encodes meta-vinculin-specific difference peptide. Cross-species comparison reveals variable and conserved motifs in the meta-vinculin insert"
2821:
Turner CE, Miller JT (June 1994). "Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region".
2518:"Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding"
1473:
Vinculin is present in equilibrium between an active and inactive state. The active state is triggered upon binding to its designated partner. These changes occur when vinculin interacts with
3431:
3162:
Deroanne CF, Colige AC, Nusgens BV, Lapiere CM (May 1996). "Modulation of expression and assembly of vinculin during in vitro fibrillar collagen-induced angiogenesis and its reversal".
2049:
Ezzell RM, Goldmann WH, Wang N, Parashurama N, Parasharama N, Ingber DE (February 1997). "Vinculin promotes cell spreading by mechanically coupling integrins to the cytoskeleton".
1443:
cytoskeleton. The complex at the focal adhesions consists of several proteins such as vinculin, α-actinin, paxillin, and talin, at the intracellular face of the plasma membrane.
3536:
3521:
405:
304:
1602:
3682:
3446:
1976:
Goldmann WH, Ingber DE (January 2002). "Intact vinculin protein is required for control of cell shape, cell mechanics, and rac-dependent lamellipodia formation".
1447:
acidic phospholipids. The complex then serves to anchor actin filaments to the membrane and thus, helps to reinforce force on talin within the focal adhesions.
3596:
3581:
1460:
spreading by promoting recruitment of cytoskeletal proteins to the focal adhesion complex at the site of integrin binding. Vinculin's ability to interact with
3566:
3416:
3191:
Maeda M, Holder E, Lowes B, Valent S, Bies RD (January 1997). "Dilated cardiomyopathy associated with deficiency of the cytoskeletal protein metavinculin".
2726:
Mulligan LM, Gardner E, Telenius H, Ponder BA (August 1992). "Complementary physical and genetic techniques map the vinculin (VCL) gene on chromosome 10q".
1930:
Burridge K, Feramisco JR (March 1980). "Microinjection and localization of a 130K protein in living fibroblasts: a relationship to actin and fibronectin".
1489:
is thought to be the major initiator of vinculin activation due to its presence in focal complexes. The combinatorial model of vinculin states that either
3506:
1341:
protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring
1043:
1403:
Essentially, there is an 835 amino acid N-terminal head, which is split into four domains. This is linked to the C-terminal tail with a linker region.
1024:
227:
1887:
Geiger B (September 1979). "A 130K protein from chicken gizzard: its localization at the termini of microfilament bundles in cultured chicken cells".
2691:
Koteliansky VE, Ogryzko EP, Zhidkova NI, Weller PA, Critchley DR, Vancompernolle K, Vandekerckhove J, Strasser P, Way M, Gimona M (March 1992).
6002:
5997:
3396:
1869:
1786:
1498:
4310:
1851:
3491:
391:
3675:
3611:
2954:
Johnson RP, Craig SW (January 1995). "F-actin binding site masked by the intramolecular association of vinculin head and tail domains".
2881:
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995).
1251:
1258:
368:
3461:
2011:
Xu W, Baribault H, Adamson ED (January 1998). "Vinculin knockout results in heart and brain defects during embryonic development".
3133:
Scott GA, Liang H, Cassidy LL (August 1995). "Developmental regulation of focal contact protein expression in human melanocytes".
6007:
4829:
2428:"Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling"
1838:
1817:
3650:: Human vinculin (head domain, Vh1, residues 1-258) in complex with Shigella's IpaA vinculin binding site 2 (residues 565-587)
3222:"Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins"
2477:"Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins"
2248:"Variable and constant regions in the C-terminus of vinculin and metavinculin. Cloning and expression of fragments in E. coli"
1455:
extension. It was discovered that cells that are deficient in vinculin have growth cones that advance more slowly, as well as
5098:
4941:
3668:
290:
265:
3635:: Human vinculin (head domain, Vh1, residues 1-258) in complex with Shigella's IpaA vinculin binding site (residues 602-633)
1834:
1622:
58:
5977:
5531:
2882:
2426:
Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, Bagrodia S, Thomas S, Leventhal PS (May 1999).
1813:
3560:: Human Vinculin Head Domain (VH1, 1-258) in Complex with Human Alpha-Actinin's Vinculin-Binding Site (Residues 731-760)
3485:: Human vinculin head domain VH1, residues 1-258, in complex with humantalin's vinculin binding site 1, residues 607-636
2800:
Turner CE, Burridge K (June 1989). "Detection of metavinculin in human platelets using a modified talin overlay assay".
2755:
Weller PA, Ogryzko EP, Corben EB, Zhidkova NI, Patel B, Price GJ, Spurr NK, Koteliansky VE, Critchley DR (August 1990).
207:
2883:"Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence"
4238:
1759:
3057:"Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter"
3026:
Fausser JL, Ungewickell E, Ruch JV, Lesot H (October 1993). "Interaction of vinculin with the clathrin heavy chain".
3055:
Moiseyeva EP, Weller PA, Zhidkova NI, Corben EB, Patel B, Jasinska I, Koteliansky VE, Critchley DR (February 1993).
2567:"Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions"
1793:
symptoms, anti-CdtB antibodies have been identified to affect vinculin function, which is required in gut motility.
1477:
points to which it is binding to. When vinculin resides in its inactive form, the protein is kept designated to the
5709:
404:
303:
3389:
397:
296:
5942:
2207:"Comparative biochemical analysis suggests that vinculin and metavinculin cooperate in muscular adhesion sites"
1790:
1707:
1088:
215:
2846:
Salgia R, Li JL, Lo SH, Brunkhorst B, Kansas GS, Sobhany ES, Sun Y, Pisick E, Hallek M, Ernst T (March 1995).
1610:
1310:
1069:
3292:"The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton"
2387:"The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton"
4361:
3715:
2662:
Critchley DR (November 2004). "Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion".
279:
1606:
2993:"The intracellular distribution of vinculin and alpha 2 integrin in epithelial cells and chondrocytes"
4630:
3382:
2565:
Mandai K, Nakanishi H, Satoh A, Takahashi K, Satoh K, Nishioka H, Mizoguchi A, Takai Y (March 1999).
1420:
194:
5937:
4570:
1680:
1666:
1643:
3440:: Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969)
2166:"Co-existence of vinculin and a vinculin-like protein of higher molecular weight in smooth muscle"
1505:. This activation takes place by separation of the head-tail connection within inactive vinculin.
1435:. These are complexes that nucleate actin filaments and crosslinkers between the external medium,
1380:-rich middle segment. Vinculin consists of a globular head domain that contains binding sites for
4390:
4020:
3092:"Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton"
2979:
2640:
2277:
1955:
1912:
1658:
1646:
of vinculin to talin, stabilising integrin-mediated cell-matrix junctions. Talin, in turn, links
1428:
239:
1527:
human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969)
1234:
1213:
1209:
1183:
1162:
1158:
5788:
5491:
4152:
3354:
3333:
3313:
3278:
3243:
3208:
3179:
3150:
3121:
3078:
3043:
3014:
2971:
2942:
2897:
2869:
2834:
2809:
2788:
2743:
2714:
2679:
2632:
2596:
2547:
2498:
2457:
2408:
2367:
2326:
2269:
2228:
2187:
2146:
2110:
2066:
2028:
1993:
1947:
1904:
1735:
1597:
187:
51:
5511:
3090:
Yoshida M, Westlin WF, Wang N, Ingber DE, Rosenzweig A, Resnick N, Gimbrone MA (April 1996).
2848:"Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL"
1388:
as well as a tyrosine phosphorylation site, while the tail region contains binding sites for
5736:
5443:
5428:
5423:
5418:
5413:
5403:
5324:
5033:
5013:
4983:
4978:
4860:
4215:
4210:
3303:
3268:
3233:
3200:
3171:
3142:
3111:
3103:
3068:
3035:
3004:
2963:
2932:
2922:
2859:
2826:
2778:
2768:
2735:
2704:
2671:
2624:
2586:
2578:
2537:
2529:
2488:
2447:
2439:
2398:
2357:
2316:
2308:
2259:
2218:
2177:
2138:
2100:
2058:
2020:
1985:
1939:
1896:
1432:
484:
415:
359:
314:
5653:
5648:
5643:
5638:
5393:
5383:
5373:
5368:
5339:
5043:
5038:
4085:
3973:
3963:
3938:
3918:
3822:
3802:
1589:
649:
642:
5878:
4492:
4342:
4225:
4045:
3039:
1747:
1699:
1639:
1436:
1381:
459:
20:
1314:
Vinculin is a globular protein approximately 115 x 85 x 65 angstroms in linear dimension.
235:
5841:
5704:
4401:
4232:
3741:
3146:
3116:
3091:
2709:
2692:
2591:
2566:
2542:
2517:
2452:
2427:
2321:
2296:
1723:
1711:
1703:
1482:
1474:
1424:
1349:
1323:
3073:
3056:
2182:
2165:
1943:
1683:
that define the VBS are themselves 'masked' and are buried in the core of a series of
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
726:
721:
716:
711:
706:
701:
696:
691:
5991:
5905:
5900:
4865:
4735:
4684:
4634:
4574:
4496:
4464:
4405:
4191:
3710:
3545:: Vinculin head (1-258) in complex with the talin vinculin binding site 3 (1945-1969)
3363:
3342:
2937:
2910:
2783:
2756:
2739:
2264:
2247:
1900:
1739:
1731:
1695:
1494:
1486:
678:
2644:
2281:
1959:
1916:
1551:
34:
5749:
4804:
4559:
4103:
3695:
3530:: Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)
2983:
1654:
1635:
1585:
1452:
1338:
1334:
477:
256:
5721:
5699:
1385:
219:
2757:"Complete sequence of human vinculin and assignment of the gene to chromosome 10"
1563:
1415:
Cell spreading and movement occur through the process of binding of cell surface
243:
5895:
5846:
5716:
5606:
4936:
4380:
4335:
4254:
4176:
3724:
1874:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1856:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1766:
1677:
1673:
1670:
1662:
1369:
3660:
2915:
Proceedings of the
National Academy of Sciences of the United States of America
2761:
Proceedings of the
National Academy of Sciences of the United States of America
560:
5947:
5866:
5856:
5744:
4855:
4834:
4600:
4537:
4532:
4527:
4507:
4482:
4470:
4456:
4451:
4446:
4441:
4436:
4431:
4426:
4421:
4416:
4278:
4160:
4149:
4135:
3751:
2628:
2105:
2088:
1373:
376:
273:
223:
3273:
3256:
2362:
2345:
5776:
5771:
5766:
5726:
5564:
5559:
5554:
4912:
4892:
4547:
4542:
4522:
4517:
4512:
4502:
4411:
4315:
4249:
3455:: Human vinculin head (1-258) in complex with human vinculin tail (879-1066)
3308:
3291:
3238:
3221:
2864:
2847:
2773:
2493:
2476:
2403:
2386:
2164:
Feramisco JR, Smart JE, Burridge K, Helfman DM, Thomas GP (September 1982).
1743:
1647:
1478:
1456:
988:
620:
498:
443:
430:
342:
329:
231:
3204:
3175:
3009:
2992:
2927:
2830:
2683:
2636:
2600:
2582:
2533:
2461:
2232:
2223:
2206:
2150:
2114:
2062:
1997:
1989:
3317:
3282:
3247:
3212:
3183:
3154:
3125:
3107:
3082:
3047:
3018:
2975:
2946:
2901:
2873:
2838:
2813:
2792:
2747:
2718:
2551:
2502:
2443:
2412:
2371:
2330:
2312:
2273:
2191:
2070:
2032:
2024:
1951:
1522:
1298:
1293:
5851:
5783:
5756:
5623:
5611:
5486:
5481:
4922:
4917:
4839:
4273:
4268:
4130:
2911:"Pattern formation and handedness in the cytoskeleton of human platelets"
2297:"Immunolocalization of meta-vinculin in human smooth and cardiac muscles"
1908:
1772:
1558:
1461:
1416:
1393:
1327:
1282:
1133:
1114:
3605:: Vinculin Head (0-258) in Complex with the Talin Rod residues 1630-1652
3590:: Vinculin Head (0-258) in Complex with the Talin Rod residues 2345-2369
5917:
5871:
5761:
5691:
5660:
5590:
5585:
5549:
5544:
5539:
5506:
5476:
5471:
5466:
5461:
5146:
5078:
5073:
5068:
5063:
5058:
4950:
4887:
4375:
4320:
4261:
4244:
4205:
3691:
3368:
3358:
3347:
3337:
2675:
1490:
1389:
1377:
1353:
1342:
1100:
1055:
2142:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
5836:
5818:
5813:
5808:
5803:
5793:
5628:
5521:
5516:
5501:
5496:
5408:
5354:
5319:
5294:
5289:
5284:
5279:
5269:
5264:
5254:
5239:
5234:
5116:
5111:
5106:
5018:
5008:
4988:
4973:
4968:
4963:
4958:
4824:
4595:
4590:
4347:
4013:
4008:
3998:
3776:
3575:: Vinculin Head (0-258) in Complex with the Talin Rod Residue 820-844
3425:: CRYSTAL STRUCTURE OF THE VINCULIN TAIL AND A PATHWAY FOR ACTIVATION
2967:
2205:
Witt S, Zieseniss A, Fock U, Jockusch BM, Illenberger S (July 2004).
1778:
1617:
1397:
1266:
1010:
2246:
Strasser P, Gimona M, Herzog M, Geiger B, Small JV (February 1993).
3515:: Crystal structure of human full-length vinculin (residues 1-1066)
2295:
Belkin AM, Ornatsky OI, Glukhova MA, Koteliansky VE (August 1988).
5861:
5633:
5616:
5453:
5448:
5438:
5433:
5398:
5388:
5378:
5363:
5344:
5334:
5329:
5314:
5309:
5304:
5299:
5274:
5259:
5249:
5244:
5229:
5224:
5204:
5199:
5194:
5189:
5184:
5179:
5174:
5169:
5164:
5159:
5154:
5126:
5121:
5088:
5083:
5053:
5048:
5028:
5023:
5003:
4993:
4908:
4786:
4781:
4776:
4771:
4766:
4761:
4756:
4751:
4746:
4741:
4725:
4720:
4715:
4710:
4705:
4700:
4695:
4690:
4665:
4660:
4655:
4650:
4645:
4640:
4620:
4615:
4610:
4605:
4585:
4580:
4290:
4220:
4169:
4166:
4163:
4155:
4144:
4141:
4138:
4123:
4118:
4113:
4108:
4080:
4070:
4055:
3988:
3978:
3958:
3933:
3928:
3913:
3903:
3898:
3893:
3888:
3883:
3878:
3863:
3817:
3812:
3807:
3797:
3792:
3787:
3766:
3761:
3756:
3746:
3733:
1684:
1651:
1502:
1440:
1331:
1309:
2087:
Borgon RA, Vonrhein C, Bricogne G, Bois PR, Izard T (July 2004).
973:
969:
5962:
5957:
5952:
5912:
5883:
5798:
5675:
5670:
5665:
5569:
5219:
5214:
5209:
5136:
5131:
4998:
4880:
4875:
4870:
4330:
4325:
4283:
4196:
4186:
4181:
4075:
4065:
4060:
4050:
4040:
4035:
4030:
4025:
3948:
3873:
3868:
3858:
3853:
3848:
3843:
3838:
3833:
1715:
1579:
1546:
211:
3664:
3378:
658:
3374:
3257:"Vinculin is associated with the E-cadherin adhesion complex"
3255:
Hazan RB, Kang L, Roe S, Borgen PI, Rimm DL (December 1997).
2346:"Vinculin is associated with the E-cadherin adhesion complex"
2344:
Hazan RB, Kang L, Roe S, Borgen PI, Rimm DL (December 1997).
1497:
can activate vinculin either alone or with the assistance of
3353:
Overview of all the structural information available in the
3332:
Overview of all the structural information available in the
1360:
vinculin to heterodimerize and work in a dependent fashion.
2991:
Hirsch MS, Law LY, Trinkaus-Randall V, Svoboda KK (1995).
1718:
in the 3' coding region, thus encoding a longer isoform
467:
1710:(contractile) state co-express (along with vinculin) a
1368:
Vinculin is a 117-kDa cytoskeletal protein with 1066
632:
1376:
domain and a basic C-terminal domain separated by a
5930:
5829:
5735:
5690:
5599:
5578:
5530:
5353:
5145:
5097:
4949:
4935:
4901:
4848:
4817:
4797:
4676:
4558:
4389:
4371:
4360:
4303:
4096:
3775:
3732:
3723:
3709:
3702:
3500:: Vinculin complexed with the VBS1 helix from talin
1978:
1616:
1596:
1578:
1573:
1557:
1545:
1537:
1532:
1515:
1227:
1202:
1176:
1151:
2516:Brown MC, Perrotta JA, Turner CE (November 1996).
1830:
1828:
1826:
1809:
1807:
1805:
3620:: Structure of Vinculin VD1 / IpaA560-633 complex
1485:points bound from the active state. The molecule
414:
313:
1423:adhesion molecules. Vinculin is associated with
2082:
2080:
1971:
1969:
1835:GRCm38: Ensembl release 89: ENSMUSG00000021823
3676:
3470:: Crystal structure of a cytoskeletal protein
3390:
1348:Discovered independently by Benny Geiger and
8:
3220:Mazaki Y, Hashimoto S, Sabe H (March 1997).
2475:Mazaki Y, Hashimoto S, Sabe H (March 1997).
2044:
2042:
1814:GRCh38: Ensembl release 89: ENSG00000035403
4946:
4386:
4368:
3729:
3720:
3706:
3683:
3669:
3661:
3397:
3383:
3375:
1570:
1521:
984:
674:
455:
354:
251:
69:
3307:
3272:
3237:
3115:
3072:
3008:
2936:
2926:
2863:
2782:
2772:
2708:
2590:
2541:
2492:
2451:
2402:
2361:
2320:
2263:
2222:
2181:
2104:
3412:
1801:
1352:, its sequence is 20%–30% similar to α-
1326:plaques that is involved in linkage of
16:Mammalian protein found in Homo sapiens
1512:
1322:is a membrane-cytoskeletal protein in
24:
3040:10.1093/oxfordjournals.jbchem.a124206
2089:"Crystal structure of human vinculin"
1787:Small Intestinal Bacterial Overgrowth
1730:structures, such as dense plaques in
924:negative regulation of cell migration
419:
380:
375:
318:
277:
272:
198:, CMD1W, CMH15, HEL114, MV, Mvinculin
7:
1687:bundles that make up the talin rod.
929:protein localization to cell surface
579:endothelial cell of lymphatic vessel
3296:The Journal of Biological Chemistry
3261:The Journal of Biological Chemistry
3226:The Journal of Biological Chemistry
3061:The Journal of Biological Chemistry
2852:The Journal of Biological Chemistry
2481:The Journal of Biological Chemistry
2391:The Journal of Biological Chemistry
2350:The Journal of Biological Chemistry
2211:The Journal of Biological Chemistry
2170:The Journal of Biological Chemistry
1702:(and probably to a lower extent in
1642:and talin-like molecules, enabling
1356:, which serves a similar function.
3147:10.1111/j.1600-0749.1995.tb00667.x
2710:10.1111/j.1432-1033.1992.tb16692.x
1224:
1199:
1173:
1148:
1124:
1105:
1079:
1060:
1034:
1015:
637:
555:
493:
472:
14:
3290:Hazan RB, Norton L (April 1998).
2385:Hazan RB, Norton L (April 1998).
1372:. The protein contains an acidic
4311:Wiskott–Aldrich syndrome protein
3640:
3625:
3610:
3595:
3580:
3565:
3550:
3535:
3520:
3505:
3490:
3475:
3460:
3445:
3430:
3415:
2802:European Journal of Cell Biology
2697:European Journal of Biochemistry
2664:Biochemical Society Transactions
722:ubiquitin protein ligase binding
648:
641:
403:
396:
390:
367:
302:
295:
289:
264:
33:
5532:Microtubule organising proteins
2617:Digestive Diseases and Sciences
1665:is LxxAAxxVAxxVxxLIxxA, with a
793:inner dense plaque of desmosome
758:outer dense plaque of desmosome
914:morphogenesis of an epithelium
659:More reference expression data
621:More reference expression data
1:
5579:Microtubule severing proteins
3074:10.1016/S0021-9258(18)53612-7
2183:10.1016/S0021-9258(18)33927-9
1944:10.1016/s0092-8674(80)80035-3
1574:Available protein structures:
904:epithelial cell-cell adhesion
571:tunica media of zone of aorta
388:
287:
6003:Peripheral membrane proteins
5998:Genes on human chromosome 10
4239:actin depolymerizing factors
2825:. 107 ( Pt 6) (6): 1583–91.
2740:10.1016/0888-7543(92)90066-2
2265:10.1016/0014-5793(93)81274-4
1901:10.1016/0092-8674(79)90368-4
889:regulation of cell migration
868:ficolin-1-rich granule lumen
702:structural molecule activity
5717:Plakoglobin (gamma catenin)
3096:The Journal of Cell Biology
2571:The Journal of Cell Biology
2522:The Journal of Cell Biology
2432:The Journal of Cell Biology
2301:The Journal of Cell Biology
1758:Vinculin has been shown to
1638:are predominantly found in
1431:, resulting in significant
6024:
3164:Experimental Cell Research
2051:Experimental Cell Research
1330:adhesion molecules to the
899:adherens junction assembly
18:
5973:
3410:
2629:10.1007/s10620-014-3435-5
2106:10.1016/j.str.2004.05.009
1870:"Mouse PubMed Reference:"
1852:"Human PubMed Reference:"
1569:
1520:
1297:
1292:
1288:
1281:
1265:
1246:
1231:
1206:
1195:
1180:
1155:
1144:
1131:
1127:
1112:
1108:
1099:
1086:
1082:
1067:
1063:
1054:
1041:
1037:
1022:
1018:
1009:
994:
987:
983:
967:
677:
673:
656:
640:
631:
618:
567:
558:
545:Descending thoracic aorta
505:
496:
466:
458:
454:
437:
424:
387:
366:
357:
353:
336:
323:
286:
263:
254:
250:
205:
202:
192:
185:
180:
77:
72:
55:
50:
45:
41:
32:
27:
5943:Prokaryotic cytoskeleton
3367:(Mouse Vinculin) at the
3346:(Human Vinculin) at the
3274:10.1074/jbc.272.51.32448
2909:Hagmann J (April 1993).
2363:10.1074/jbc.272.51.32448
1259:Chr 14: 20.98 – 21.08 Mb
959:neutrophil degranulation
949:apical junction assembly
3309:10.1074/jbc.273.15.9078
3239:10.1074/jbc.272.11.7437
3028:Journal of Biochemistry
2865:10.1074/jbc.270.10.5039
2823:Journal of Cell Science
2774:10.1073/pnas.87.15.5667
2494:10.1074/jbc.272.11.7437
2404:10.1074/jbc.273.15.9078
858:secretory granule lumen
778:cell-substrate junction
6008:Cell adhesion proteins
3205:10.1161/01.cir.95.1.17
3176:10.1006/excr.1996.0131
3010:10.1002/sca.4950160306
2928:10.1073/pnas.90.8.3280
2831:10.1242/jcs.107.6.1583
2583:10.1083/jcb.144.5.1001
2534:10.1083/jcb.135.4.1109
2224:10.1074/jbc.M314245200
2063:10.1006/excr.1996.3451
1990:10.1006/bbrc.2001.6243
1411:Mechanism and function
1315:
954:lamellipodium assembly
909:platelet degranulation
863:specific granule lumen
421:14 A3|14 11.53 cM
4563:(hard alpha-keratins)
4394:(soft alpha-keratins)
3135:Pigment Cell Research
3108:10.1083/jcb.133.2.445
2896:(6547 Suppl): 3–174.
2444:10.1083/jcb.145.4.851
2313:10.1083/jcb.107.2.545
2025:10.1242/dev.125.2.327
1313:
1252:Chr 10: 74 – 74.12 Mb
848:extracellular exosome
748:extracellular vesicle
717:alpha-catenin binding
525:right coronary artery
382:Chromosome 14 (mouse)
280:Chromosome 10 (human)
5978:cytoskeletal defects
5938:Major sperm proteins
1421:extracellular matrix
1318:In mammalian cells,
944:platelet aggregation
939:cell-matrix adhesion
803:extracellular region
697:dystroglycan binding
692:beta-catenin binding
521:smooth muscle tissue
73:List of PDB id codes
46:Available structures
4391:Epithelial keratins
1669:prediction of four
1667:secondary structure
2676:10.1042/BST0320831
1736:intercalated discs
1714:carrying an extra
1659:consensus sequence
1451:and inhibition of
1429:adherens junctions
1316:
1089:ENSMUSG00000021823
894:muscle contraction
882:Biological process
818:actin cytoskeleton
768:cell-cell junction
736:Cellular component
685:Molecular function
583:tibiofemoral joint
5985:
5984:
5926:
5925:
5686:
5685:
4931:
4930:
4813:
4812:
4356:
4355:
4299:
4298:
3658:
3657:
2143:10.1021/bi052136l
1632:
1631:
1628:
1627:
1623:structure summary
1345:to the membrane.
1308:
1307:
1304:
1303:
1277:
1276:
1242:
1241:
1221:
1220:
1191:
1190:
1170:
1169:
1140:
1139:
1121:
1120:
1095:
1094:
1076:
1075:
1050:
1049:
1031:
1030:
979:
978:
783:adherens junction
669:
668:
665:
664:
627:
626:
614:
613:
552:
551:
450:
449:
349:
348:
176:
175:
172:
171:
56:Ortholog search:
6015:
4947:
4387:
4369:
3730:
3721:
3707:
3685:
3678:
3671:
3662:
3644:
3629:
3614:
3599:
3584:
3569:
3554:
3539:
3524:
3509:
3494:
3479:
3464:
3449:
3434:
3419:
3399:
3392:
3385:
3376:
3321:
3311:
3286:
3276:
3267:(51): 32448–53.
3251:
3241:
3216:
3187:
3158:
3129:
3119:
3086:
3076:
3051:
3022:
3012:
2987:
2968:10.1038/373261a0
2950:
2940:
2930:
2905:
2887:
2877:
2867:
2842:
2817:
2796:
2786:
2776:
2751:
2722:
2712:
2687:
2649:
2648:
2611:
2605:
2604:
2594:
2562:
2556:
2555:
2545:
2513:
2507:
2506:
2496:
2472:
2466:
2465:
2455:
2423:
2417:
2416:
2406:
2382:
2376:
2375:
2365:
2356:(51): 32448–53.
2341:
2335:
2334:
2324:
2292:
2286:
2285:
2267:
2243:
2237:
2236:
2226:
2217:(30): 31533–43.
2202:
2196:
2195:
2185:
2176:(18): 11024–31.
2161:
2155:
2154:
2125:
2119:
2118:
2108:
2084:
2075:
2074:
2046:
2037:
2036:
2008:
2002:
2001:
1973:
1964:
1963:
1927:
1921:
1920:
1884:
1878:
1877:
1866:
1860:
1859:
1848:
1842:
1832:
1821:
1811:
1748:skeletal muscles
1706:) in their well-
1700:skeletal muscles
1571:
1525:
1513:
1433:protein dynamics
1337:. Vinculin is a
1290:
1289:
1261:
1254:
1237:
1225:
1216:
1200:
1196:RefSeq (protein)
1186:
1174:
1165:
1149:
1125:
1106:
1080:
1061:
1035:
1016:
985:
727:cadherin binding
675:
661:
652:
645:
638:
623:
563:
561:Top expressed in
556:
541:seminal vesicula
529:popliteal artery
501:
499:Top expressed in
494:
473:
456:
446:
433:
422:
407:
400:
394:
383:
371:
355:
345:
332:
321:
306:
299:
293:
282:
268:
252:
246:
197:
190:
167:
70:
64:
43:
42:
37:
25:
6023:
6022:
6018:
6017:
6016:
6014:
6013:
6012:
5988:
5987:
5986:
5981:
5969:
5922:
5825:
5731:
5682:
5595:
5574:
5526:
5349:
5141:
5093:
4939:
4927:
4897:
4844:
4809:
4793:
4677:Ungrouped alpha
4672:
4562:
4554:
4393:
4379:
4373:
4363:
4352:
4295:
4092:
3771:
3713:
3698:
3689:
3659:
3654:
3651:
3645:
3636:
3630:
3621:
3615:
3606:
3600:
3591:
3585:
3576:
3570:
3561:
3555:
3546:
3540:
3531:
3525:
3516:
3510:
3501:
3495:
3486:
3480:
3471:
3465:
3456:
3450:
3441:
3435:
3426:
3420:
3406:
3403:
3329:
3324:
3302:(15): 9078–84.
3289:
3254:
3232:(11): 7437–44.
3219:
3190:
3161:
3132:
3089:
3054:
3025:
2990:
2962:(6511): 261–4.
2953:
2908:
2885:
2880:
2858:(10): 5039–47.
2845:
2820:
2799:
2767:(15): 5667–71.
2754:
2725:
2690:
2670:(Pt 5): 831–6.
2661:
2657:
2655:Further reading
2652:
2623:(5): 1195–205.
2613:
2612:
2608:
2564:
2563:
2559:
2515:
2514:
2510:
2487:(11): 7437–44.
2474:
2473:
2469:
2425:
2424:
2420:
2397:(15): 9078–84.
2384:
2383:
2379:
2343:
2342:
2338:
2294:
2293:
2289:
2245:
2244:
2240:
2204:
2203:
2199:
2163:
2162:
2158:
2127:
2126:
2122:
2086:
2085:
2078:
2048:
2047:
2040:
2010:
2009:
2005:
1975:
1974:
1967:
1929:
1928:
1924:
1886:
1885:
1881:
1868:
1867:
1863:
1850:
1849:
1845:
1833:
1824:
1812:
1803:
1799:
1756:
1693:
1691:Splice variants
1528:
1511:
1471:
1437:plasma membrane
1413:
1366:
1299:View/Edit Mouse
1294:View/Edit Human
1257:
1250:
1247:Location (UCSC)
1233:
1212:
1208:
1182:
1161:
1157:
1070:ENSG00000035403
963:
877:
833:fascia adherens
823:zonula adherens
788:plasma membrane
731:
707:protein binding
657:
647:
646:
619:
610:
605:
601:
597:
593:
591:ascending aorta
589:
585:
581:
577:
573:
559:
548:
543:
539:
535:
533:tibial arteries
531:
527:
523:
519:
515:
511:
497:
441:
428:
420:
410:
409:
408:
401:
381:
358:Gene location (
340:
327:
319:
309:
308:
307:
300:
278:
255:Gene location (
244:VCL - orthologs
206:
193:
186:
79:
57:
23:
21:Vinculin family
17:
12:
11:
5:
6021:
6019:
6011:
6010:
6005:
6000:
5990:
5989:
5983:
5982:
5974:
5971:
5970:
5968:
5967:
5966:
5965:
5960:
5955:
5950:
5940:
5934:
5932:
5928:
5927:
5924:
5923:
5921:
5920:
5915:
5910:
5909:
5908:
5903:
5893:
5888:
5887:
5886:
5876:
5875:
5874:
5869:
5864:
5859:
5854:
5849:
5844:
5842:Corneodesmosin
5833:
5831:
5827:
5826:
5824:
5823:
5822:
5821:
5816:
5811:
5806:
5801:
5796:
5791:
5781:
5780:
5779:
5774:
5769:
5759:
5754:
5753:
5752:
5741:
5739:
5733:
5732:
5730:
5729:
5724:
5719:
5714:
5713:
5712:
5702:
5696:
5694:
5688:
5687:
5684:
5683:
5681:
5680:
5679:
5678:
5673:
5668:
5658:
5657:
5656:
5651:
5646:
5641:
5636:
5626:
5621:
5620:
5619:
5609:
5603:
5601:
5597:
5596:
5594:
5593:
5588:
5582:
5580:
5576:
5575:
5573:
5572:
5567:
5562:
5557:
5552:
5547:
5542:
5536:
5534:
5528:
5527:
5525:
5524:
5519:
5514:
5509:
5504:
5499:
5494:
5489:
5484:
5479:
5474:
5469:
5464:
5457:
5456:
5451:
5446:
5441:
5436:
5431:
5426:
5421:
5416:
5411:
5406:
5401:
5396:
5391:
5386:
5381:
5376:
5371:
5366:
5359:
5357:
5351:
5350:
5348:
5347:
5342:
5337:
5332:
5327:
5322:
5317:
5312:
5307:
5302:
5297:
5292:
5287:
5282:
5277:
5272:
5267:
5262:
5257:
5252:
5247:
5242:
5237:
5232:
5227:
5222:
5217:
5212:
5207:
5202:
5197:
5192:
5187:
5182:
5177:
5172:
5167:
5162:
5157:
5151:
5149:
5143:
5142:
5140:
5139:
5134:
5129:
5124:
5119:
5114:
5109:
5103:
5101:
5095:
5094:
5092:
5091:
5086:
5081:
5076:
5071:
5066:
5061:
5056:
5051:
5046:
5041:
5036:
5031:
5026:
5021:
5016:
5011:
5006:
5001:
4996:
4991:
4986:
4981:
4976:
4971:
4966:
4961:
4955:
4953:
4944:
4933:
4932:
4929:
4928:
4926:
4925:
4920:
4915:
4909:Nuclear lamins
4905:
4903:
4899:
4898:
4896:
4895:
4890:
4885:
4884:
4883:
4878:
4873:
4863:
4858:
4852:
4850:
4846:
4845:
4843:
4842:
4837:
4832:
4827:
4821:
4819:
4815:
4814:
4811:
4810:
4808:
4807:
4801:
4799:
4795:
4794:
4792:
4791:
4790:
4789:
4784:
4779:
4774:
4769:
4764:
4759:
4754:
4749:
4744:
4731:
4730:
4729:
4728:
4723:
4718:
4713:
4708:
4703:
4698:
4693:
4680:
4678:
4674:
4673:
4671:
4670:
4669:
4668:
4663:
4658:
4653:
4648:
4643:
4626:
4625:
4624:
4623:
4618:
4613:
4608:
4603:
4598:
4593:
4588:
4583:
4566:
4564:
4556:
4555:
4553:
4552:
4551:
4550:
4545:
4540:
4535:
4530:
4525:
4520:
4515:
4510:
4505:
4488:
4487:
4486:
4485:
4475:
4474:
4473:
4461:
4460:
4459:
4454:
4449:
4444:
4439:
4434:
4429:
4424:
4419:
4414:
4397:
4395:
4384:
4366:
4358:
4357:
4354:
4353:
4351:
4350:
4345:
4340:
4339:
4338:
4333:
4328:
4318:
4313:
4307:
4305:
4301:
4300:
4297:
4296:
4294:
4293:
4288:
4287:
4286:
4281:
4271:
4266:
4265:
4264:
4259:
4258:
4257:
4252:
4235:
4233:Arp2/3 complex
4230:
4229:
4228:
4223:
4218:
4213:
4202:
4201:
4200:
4199:
4194:
4189:
4184:
4174:
4173:
4172:
4158:
4147:
4128:
4127:
4126:
4121:
4116:
4111:
4100:
4098:
4094:
4093:
4091:
4090:
4089:
4088:
4083:
4078:
4073:
4068:
4063:
4058:
4053:
4048:
4043:
4038:
4033:
4028:
4018:
4017:
4016:
4011:
4003:
4002:
4001:
3993:
3992:
3991:
3983:
3982:
3981:
3976:
3968:
3967:
3966:
3961:
3953:
3952:
3951:
3943:
3942:
3941:
3936:
3931:
3923:
3922:
3921:
3916:
3908:
3907:
3906:
3901:
3896:
3891:
3886:
3881:
3876:
3871:
3866:
3861:
3856:
3851:
3846:
3841:
3836:
3828:
3827:
3826:
3820:
3815:
3810:
3805:
3800:
3795:
3790:
3781:
3779:
3773:
3772:
3770:
3769:
3764:
3759:
3754:
3749:
3744:
3738:
3736:
3727:
3718:
3711:Microfilaments
3704:
3700:
3699:
3690:
3688:
3687:
3680:
3673:
3665:
3656:
3655:
3653:
3652:
3646:
3639:
3637:
3631:
3624:
3622:
3616:
3609:
3607:
3601:
3594:
3592:
3586:
3579:
3577:
3571:
3564:
3562:
3556:
3549:
3547:
3541:
3534:
3532:
3526:
3519:
3517:
3511:
3504:
3502:
3496:
3489:
3487:
3481:
3474:
3472:
3466:
3459:
3457:
3451:
3444:
3442:
3436:
3429:
3427:
3421:
3414:
3411:
3408:
3407:
3404:
3402:
3401:
3394:
3387:
3379:
3373:
3372:
3351:
3328:
3327:External links
3325:
3323:
3322:
3287:
3252:
3217:
3188:
3159:
3130:
3087:
3067:(6): 4318–25.
3052:
3034:(4): 498–503.
3023:
2988:
2951:
2906:
2878:
2843:
2818:
2797:
2752:
2723:
2688:
2658:
2656:
2653:
2651:
2650:
2606:
2577:(5): 1001–17.
2557:
2528:(4): 1109–23.
2508:
2467:
2418:
2377:
2336:
2287:
2238:
2197:
2156:
2137:(6): 1805–17.
2120:
2099:(7): 1189–97.
2076:
2038:
2003:
1965:
1922:
1895:(1): 193–205.
1879:
1861:
1843:
1822:
1800:
1798:
1795:
1783:
1782:
1776:
1770:
1755:
1752:
1740:cardiomyocytes
1732:smooth muscles
1724:cardiomyopathy
1712:splice variant
1708:differentiated
1704:cardiac muscle
1696:Smooth muscles
1692:
1689:
1630:
1629:
1626:
1625:
1620:
1614:
1613:
1600:
1594:
1593:
1583:
1576:
1575:
1567:
1566:
1561:
1555:
1554:
1549:
1543:
1542:
1539:
1535:
1534:
1530:
1529:
1526:
1518:
1517:
1510:
1507:
1483:focal adhesion
1475:focal adhesion
1470:
1467:
1425:focal adhesion
1412:
1409:
1365:
1362:
1350:Keith Burridge
1324:focal adhesion
1306:
1305:
1302:
1301:
1296:
1286:
1285:
1279:
1278:
1275:
1274:
1272:
1270:
1263:
1262:
1255:
1248:
1244:
1243:
1240:
1239:
1229:
1228:
1222:
1219:
1218:
1204:
1203:
1197:
1193:
1192:
1189:
1188:
1178:
1177:
1171:
1168:
1167:
1153:
1152:
1146:
1142:
1141:
1138:
1137:
1129:
1128:
1122:
1119:
1118:
1110:
1109:
1103:
1097:
1096:
1093:
1092:
1084:
1083:
1077:
1074:
1073:
1065:
1064:
1058:
1052:
1051:
1048:
1047:
1039:
1038:
1032:
1029:
1028:
1020:
1019:
1013:
1007:
1006:
1001:
996:
992:
991:
981:
980:
977:
976:
965:
964:
962:
961:
956:
951:
946:
941:
936:
934:axon extension
931:
926:
921:
916:
911:
906:
901:
896:
891:
885:
883:
879:
878:
876:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
773:focal adhesion
770:
765:
760:
755:
750:
745:
739:
737:
733:
732:
730:
729:
724:
719:
714:
709:
704:
699:
694:
688:
686:
682:
681:
671:
670:
667:
666:
663:
662:
654:
653:
635:
629:
628:
625:
624:
616:
615:
612:
611:
609:
608:
607:left lung lobe
604:
600:
596:
592:
588:
584:
580:
576:
572:
568:
565:
564:
553:
550:
549:
547:
546:
542:
538:
534:
530:
526:
522:
518:
514:
510:
509:saphenous vein
506:
503:
502:
490:
489:
481:
470:
464:
463:
460:RNA expression
452:
451:
448:
447:
439:
435:
434:
426:
423:
418:
412:
411:
402:
395:
389:
385:
384:
379:
373:
372:
364:
363:
351:
350:
347:
346:
338:
334:
333:
325:
322:
317:
311:
310:
301:
294:
288:
284:
283:
276:
270:
269:
261:
260:
248:
247:
204:
200:
199:
191:
183:
182:
178:
177:
174:
173:
170:
169:
75:
74:
66:
65:
54:
48:
47:
39:
38:
30:
29:
15:
13:
10:
9:
6:
4:
3:
2:
6020:
6009:
6006:
6004:
6001:
5999:
5996:
5995:
5993:
5980:
5979:
5972:
5964:
5961:
5959:
5956:
5954:
5951:
5949:
5946:
5945:
5944:
5941:
5939:
5936:
5935:
5933:
5929:
5919:
5916:
5914:
5911:
5907:
5904:
5902:
5899:
5898:
5897:
5894:
5892:
5889:
5885:
5882:
5881:
5880:
5877:
5873:
5870:
5868:
5865:
5863:
5860:
5858:
5855:
5853:
5850:
5848:
5845:
5843:
5840:
5839:
5838:
5835:
5834:
5832:
5828:
5820:
5817:
5815:
5812:
5810:
5807:
5805:
5802:
5800:
5797:
5795:
5792:
5790:
5787:
5786:
5785:
5782:
5778:
5775:
5773:
5770:
5768:
5765:
5764:
5763:
5760:
5758:
5755:
5751:
5748:
5747:
5746:
5743:
5742:
5740:
5738:
5734:
5728:
5725:
5723:
5722:Delta catenin
5720:
5718:
5715:
5711:
5708:
5707:
5706:
5703:
5701:
5700:Alpha catenin
5698:
5697:
5695:
5693:
5689:
5677:
5674:
5672:
5669:
5667:
5664:
5663:
5662:
5659:
5655:
5652:
5650:
5647:
5645:
5642:
5640:
5637:
5635:
5632:
5631:
5630:
5627:
5625:
5622:
5618:
5615:
5614:
5613:
5610:
5608:
5605:
5604:
5602:
5598:
5592:
5589:
5587:
5584:
5583:
5581:
5577:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5537:
5535:
5533:
5529:
5523:
5520:
5518:
5515:
5513:
5510:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5488:
5485:
5483:
5480:
5478:
5475:
5473:
5470:
5468:
5465:
5463:
5460:cytoplasmic:
5459:
5458:
5455:
5452:
5450:
5447:
5445:
5442:
5440:
5437:
5435:
5432:
5430:
5427:
5425:
5422:
5420:
5417:
5415:
5412:
5410:
5407:
5405:
5402:
5400:
5397:
5395:
5392:
5390:
5387:
5385:
5382:
5380:
5377:
5375:
5372:
5370:
5367:
5365:
5361:
5360:
5358:
5356:
5352:
5346:
5343:
5341:
5338:
5336:
5333:
5331:
5328:
5326:
5323:
5321:
5318:
5316:
5313:
5311:
5308:
5306:
5303:
5301:
5298:
5296:
5293:
5291:
5288:
5286:
5283:
5281:
5278:
5276:
5273:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5246:
5243:
5241:
5238:
5236:
5233:
5231:
5228:
5226:
5223:
5221:
5218:
5216:
5213:
5211:
5208:
5206:
5203:
5201:
5198:
5196:
5193:
5191:
5188:
5186:
5183:
5181:
5178:
5176:
5173:
5171:
5168:
5166:
5163:
5161:
5158:
5156:
5153:
5152:
5150:
5148:
5144:
5138:
5135:
5133:
5130:
5128:
5125:
5123:
5120:
5118:
5115:
5113:
5110:
5108:
5105:
5104:
5102:
5100:
5096:
5090:
5087:
5085:
5082:
5080:
5077:
5075:
5072:
5070:
5067:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5040:
5037:
5035:
5032:
5030:
5027:
5025:
5022:
5020:
5017:
5015:
5012:
5010:
5007:
5005:
5002:
5000:
4997:
4995:
4992:
4990:
4987:
4985:
4982:
4980:
4977:
4975:
4972:
4970:
4967:
4965:
4962:
4960:
4957:
4956:
4954:
4952:
4948:
4945:
4943:
4938:
4934:
4924:
4921:
4919:
4916:
4914:
4910:
4907:
4906:
4904:
4900:
4894:
4891:
4889:
4886:
4882:
4879:
4877:
4874:
4872:
4869:
4868:
4867:
4866:Neurofilament
4864:
4862:
4859:
4857:
4854:
4853:
4851:
4847:
4841:
4838:
4836:
4833:
4831:
4828:
4826:
4823:
4822:
4820:
4816:
4806:
4803:
4802:
4800:
4796:
4788:
4785:
4783:
4780:
4778:
4775:
4773:
4770:
4768:
4765:
4763:
4760:
4758:
4755:
4753:
4750:
4748:
4745:
4743:
4740:
4739:
4738:
4737:
4736:chromosome 12
4733:
4732:
4727:
4724:
4722:
4719:
4717:
4714:
4712:
4709:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4688:
4687:
4686:
4685:chromosome 17
4682:
4681:
4679:
4675:
4667:
4664:
4662:
4659:
4657:
4654:
4652:
4649:
4647:
4644:
4642:
4639:
4638:
4637:
4636:
4635:chromosome 12
4632:
4628:
4627:
4622:
4619:
4617:
4614:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4578:
4577:
4576:
4575:chromosome 17
4572:
4568:
4567:
4565:
4561:
4560:Hair keratins
4557:
4549:
4546:
4544:
4541:
4539:
4536:
4534:
4531:
4529:
4526:
4524:
4521:
4519:
4516:
4514:
4511:
4509:
4506:
4504:
4501:
4500:
4499:
4498:
4497:chromosome 12
4494:
4490:
4489:
4484:
4481:
4480:
4479:
4476:
4472:
4469:
4468:
4467:
4466:
4465:chromosome 12
4462:
4458:
4455:
4453:
4450:
4448:
4445:
4443:
4440:
4438:
4435:
4433:
4430:
4428:
4425:
4423:
4420:
4418:
4415:
4413:
4410:
4409:
4408:
4407:
4406:chromosome 17
4403:
4399:
4398:
4396:
4392:
4388:
4385:
4382:
4377:
4370:
4367:
4365:
4362:Intermediate
4359:
4349:
4346:
4344:
4341:
4337:
4334:
4332:
4329:
4327:
4324:
4323:
4322:
4319:
4317:
4314:
4312:
4309:
4308:
4306:
4302:
4292:
4289:
4285:
4282:
4280:
4277:
4276:
4275:
4272:
4270:
4267:
4263:
4260:
4256:
4253:
4251:
4248:
4247:
4246:
4243:
4242:
4241:
4240:
4236:
4234:
4231:
4227:
4224:
4222:
4219:
4217:
4214:
4212:
4209:
4208:
4207:
4204:
4203:
4198:
4195:
4193:
4190:
4188:
4185:
4183:
4180:
4179:
4178:
4175:
4171:
4168:
4165:
4162:
4159:
4157:
4154:
4151:
4148:
4146:
4143:
4140:
4137:
4134:
4133:
4132:
4129:
4125:
4122:
4120:
4117:
4115:
4112:
4110:
4107:
4106:
4105:
4102:
4101:
4099:
4095:
4087:
4084:
4082:
4079:
4077:
4074:
4072:
4069:
4067:
4064:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4023:
4022:
4019:
4015:
4012:
4010:
4007:
4006:
4004:
4000:
3997:
3996:
3994:
3990:
3987:
3986:
3984:
3980:
3977:
3975:
3972:
3971:
3969:
3965:
3962:
3960:
3957:
3956:
3954:
3950:
3947:
3946:
3944:
3940:
3937:
3935:
3932:
3930:
3927:
3926:
3924:
3920:
3917:
3915:
3912:
3911:
3909:
3905:
3902:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3882:
3880:
3877:
3875:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3840:
3837:
3835:
3832:
3831:
3829:
3824:
3821:
3819:
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3799:
3796:
3794:
3791:
3789:
3786:
3785:
3783:
3782:
3780:
3778:
3774:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3743:
3740:
3739:
3737:
3735:
3731:
3728:
3726:
3722:
3719:
3717:
3712:
3708:
3705:
3701:
3697:
3693:
3686:
3681:
3679:
3674:
3672:
3667:
3666:
3663:
3649:
3643:
3638:
3634:
3628:
3623:
3619:
3613:
3608:
3604:
3598:
3593:
3589:
3583:
3578:
3574:
3568:
3563:
3559:
3553:
3548:
3544:
3538:
3533:
3529:
3523:
3518:
3514:
3508:
3503:
3499:
3493:
3488:
3484:
3478:
3473:
3469:
3463:
3458:
3454:
3448:
3443:
3439:
3433:
3428:
3424:
3418:
3413:
3409:
3400:
3395:
3393:
3388:
3386:
3381:
3380:
3377:
3370:
3366:
3365:
3360:
3356:
3352:
3349:
3345:
3344:
3339:
3335:
3331:
3330:
3326:
3319:
3315:
3310:
3305:
3301:
3297:
3293:
3288:
3284:
3280:
3275:
3270:
3266:
3262:
3258:
3253:
3249:
3245:
3240:
3235:
3231:
3227:
3223:
3218:
3214:
3210:
3206:
3202:
3198:
3194:
3189:
3185:
3181:
3177:
3173:
3170:(2): 215–23.
3169:
3165:
3160:
3156:
3152:
3148:
3144:
3140:
3136:
3131:
3127:
3123:
3118:
3113:
3109:
3105:
3102:(2): 445–55.
3101:
3097:
3093:
3088:
3084:
3080:
3075:
3070:
3066:
3062:
3058:
3053:
3049:
3045:
3041:
3037:
3033:
3029:
3024:
3020:
3016:
3011:
3006:
3003:(5): 275–84.
3002:
2998:
2994:
2989:
2985:
2981:
2977:
2973:
2969:
2965:
2961:
2957:
2952:
2948:
2944:
2939:
2934:
2929:
2924:
2921:(8): 3280–3.
2920:
2916:
2912:
2907:
2903:
2899:
2895:
2891:
2884:
2879:
2875:
2871:
2866:
2861:
2857:
2853:
2849:
2844:
2840:
2836:
2832:
2828:
2824:
2819:
2815:
2811:
2807:
2803:
2798:
2794:
2790:
2785:
2780:
2775:
2770:
2766:
2762:
2758:
2753:
2749:
2745:
2741:
2737:
2734:(4): 1347–9.
2733:
2729:
2724:
2720:
2716:
2711:
2706:
2703:(2): 767–72.
2702:
2698:
2694:
2689:
2685:
2681:
2677:
2673:
2669:
2665:
2660:
2659:
2654:
2646:
2642:
2638:
2634:
2630:
2626:
2622:
2618:
2610:
2607:
2602:
2598:
2593:
2588:
2584:
2580:
2576:
2572:
2568:
2561:
2558:
2553:
2549:
2544:
2539:
2535:
2531:
2527:
2523:
2519:
2512:
2509:
2504:
2500:
2495:
2490:
2486:
2482:
2478:
2471:
2468:
2463:
2459:
2454:
2449:
2445:
2441:
2438:(4): 851–63.
2437:
2433:
2429:
2422:
2419:
2414:
2410:
2405:
2400:
2396:
2392:
2388:
2381:
2378:
2373:
2369:
2364:
2359:
2355:
2351:
2347:
2340:
2337:
2332:
2328:
2323:
2318:
2314:
2310:
2307:(2): 545–53.
2306:
2302:
2298:
2291:
2288:
2283:
2279:
2275:
2271:
2266:
2261:
2258:(3): 189–94.
2257:
2253:
2249:
2242:
2239:
2234:
2230:
2225:
2220:
2216:
2212:
2208:
2201:
2198:
2193:
2189:
2184:
2179:
2175:
2171:
2167:
2160:
2157:
2152:
2148:
2144:
2140:
2136:
2132:
2124:
2121:
2116:
2112:
2107:
2102:
2098:
2094:
2090:
2083:
2081:
2077:
2072:
2068:
2064:
2060:
2056:
2052:
2045:
2043:
2039:
2034:
2030:
2026:
2022:
2019:(2): 327–37.
2018:
2014:
2007:
2004:
1999:
1995:
1991:
1987:
1984:(2): 749–55.
1983:
1979:
1972:
1970:
1966:
1961:
1957:
1953:
1949:
1945:
1941:
1938:(3): 587–95.
1937:
1933:
1926:
1923:
1918:
1914:
1910:
1906:
1902:
1898:
1894:
1890:
1883:
1880:
1875:
1871:
1865:
1862:
1857:
1853:
1847:
1844:
1840:
1836:
1831:
1829:
1827:
1823:
1819:
1815:
1810:
1808:
1806:
1802:
1796:
1794:
1792:
1789:presented as
1788:
1780:
1777:
1774:
1771:
1768:
1765:
1764:
1763:
1761:
1753:
1751:
1749:
1745:
1741:
1737:
1733:
1727:
1725:
1721:
1720:meta-vinculin
1717:
1713:
1709:
1705:
1701:
1697:
1690:
1688:
1686:
1682:
1679:
1675:
1672:
1668:
1664:
1663:binding sites
1661:for Vinculin
1660:
1656:
1653:
1649:
1645:
1641:
1637:
1636:binding sites
1624:
1621:
1619:
1615:
1612:
1608:
1604:
1601:
1599:
1595:
1591:
1587:
1584:
1581:
1577:
1572:
1568:
1565:
1562:
1560:
1556:
1553:
1550:
1548:
1544:
1540:
1536:
1531:
1524:
1519:
1514:
1508:
1506:
1504:
1500:
1496:
1492:
1488:
1484:
1480:
1476:
1468:
1466:
1463:
1458:
1454:
1448:
1444:
1442:
1438:
1434:
1430:
1426:
1422:
1419:receptors to
1418:
1410:
1408:
1404:
1401:
1399:
1395:
1391:
1387:
1383:
1379:
1375:
1371:
1363:
1361:
1357:
1355:
1351:
1346:
1344:
1340:
1336:
1333:
1329:
1325:
1321:
1312:
1300:
1295:
1291:
1287:
1284:
1280:
1273:
1271:
1268:
1264:
1260:
1256:
1253:
1249:
1245:
1238:
1236:
1230:
1226:
1223:
1217:
1215:
1211:
1205:
1201:
1198:
1194:
1187:
1185:
1179:
1175:
1172:
1166:
1164:
1160:
1154:
1150:
1147:
1145:RefSeq (mRNA)
1143:
1136:
1135:
1130:
1126:
1123:
1117:
1116:
1111:
1107:
1104:
1102:
1098:
1091:
1090:
1085:
1081:
1078:
1072:
1071:
1066:
1062:
1059:
1057:
1053:
1046:
1045:
1040:
1036:
1033:
1027:
1026:
1021:
1017:
1014:
1012:
1008:
1005:
1002:
1000:
997:
993:
990:
986:
982:
975:
971:
966:
960:
957:
955:
952:
950:
947:
945:
942:
940:
937:
935:
932:
930:
927:
925:
922:
920:
919:cell adhesion
917:
915:
912:
910:
907:
905:
902:
900:
897:
895:
892:
890:
887:
886:
884:
881:
880:
874:
871:
869:
866:
864:
861:
859:
856:
854:
851:
849:
846:
844:
841:
839:
836:
834:
831:
829:
828:membrane raft
826:
824:
821:
819:
816:
814:
811:
809:
808:cell junction
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
740:
738:
735:
734:
728:
725:
723:
720:
718:
715:
713:
712:actin binding
710:
708:
705:
703:
700:
698:
695:
693:
690:
689:
687:
684:
683:
680:
679:Gene ontology
676:
672:
660:
655:
651:
644:
639:
636:
634:
630:
622:
617:
606:
602:
598:
594:
590:
586:
582:
578:
574:
570:
569:
566:
562:
557:
554:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
507:
504:
500:
495:
492:
491:
488:
486:
482:
480:
479:
475:
474:
471:
469:
465:
461:
457:
453:
445:
440:
436:
432:
427:
417:
413:
406:
399:
393:
386:
378:
374:
370:
365:
361:
356:
352:
344:
339:
335:
331:
326:
316:
312:
305:
298:
292:
285:
281:
275:
271:
267:
262:
258:
253:
249:
245:
241:
237:
233:
229:
225:
221:
217:
213:
209:
201:
196:
189:
184:
179:
168:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
76:
71:
68:
67:
63:
60:
53:
49:
44:
40:
36:
31:
26:
22:
5975:
5890:
5750:Dystroglycan
5705:Beta catenin
4937:Microtubules
4805:Beta-keratin
4734:
4683:
4629:
4569:
4491:
4477:
4463:
4400:
4237:
4104:Tropomodulin
3696:cytoskeleton
3647:
3632:
3617:
3602:
3587:
3572:
3557:
3542:
3527:
3512:
3497:
3482:
3467:
3452:
3437:
3422:
3362:
3341:
3299:
3295:
3264:
3260:
3229:
3225:
3199:(1): 17–20.
3196:
3192:
3167:
3163:
3141:(4): 221–8.
3138:
3134:
3099:
3095:
3064:
3060:
3031:
3027:
3000:
2996:
2959:
2955:
2918:
2914:
2893:
2889:
2855:
2851:
2822:
2808:(1): 202–6.
2805:
2801:
2764:
2760:
2731:
2727:
2700:
2696:
2667:
2663:
2620:
2616:
2609:
2574:
2570:
2560:
2525:
2521:
2511:
2484:
2480:
2470:
2435:
2431:
2421:
2394:
2390:
2380:
2353:
2349:
2339:
2304:
2300:
2290:
2255:
2252:FEBS Letters
2251:
2241:
2214:
2210:
2200:
2173:
2169:
2159:
2134:
2131:Biochemistry
2130:
2123:
2096:
2092:
2057:(1): 14–26.
2054:
2050:
2016:
2012:
2006:
1981:
1977:
1935:
1931:
1925:
1892:
1888:
1882:
1873:
1864:
1855:
1846:
1785:In cases of
1784:
1757:
1754:Interactions
1728:
1719:
1694:
1655:cytoskeleton
1633:
1509:Binding site
1472:
1453:lamellipodia
1449:
1445:
1414:
1405:
1402:
1367:
1358:
1347:
1339:cytoskeletal
1335:cytoskeleton
1319:
1317:
1232:
1207:
1181:
1156:
1132:
1113:
1087:
1068:
1042:
1023:
1003:
998:
843:cytoskeleton
813:brush border
798:terminal web
603:carotid body
483:
476:
203:External IDs
78:
5896:Plakophilin
5847:Desmoplakin
5607:Tau protein
4381:Cytokeratin
4177:Tropomyosin
3725:Myofilament
3405:PDB gallery
3193:Circulation
2013:Development
1678:hydrophobic
1671:amphipathic
1533:Identifiers
1481:unlike the
1370:amino acids
442:21,083,744
429:20,979,466
341:74,121,363
328:73,995,193
181:Identifiers
5992:Categories
5976:See also:
5948:Crescentin
5867:Periplakin
5857:Envoplakin
5745:Dystrophin
5362:axonemal:
4856:Internexin
4835:Peripherin
1841:, May 2017
1820:, May 2017
1797:References
1744:costameres
1586:structures
1469:Activation
1374:N-terminal
873:sarcolemma
595:right lung
587:belly cord
487:(ortholog)
224:HomoloGene
19:See also:
5565:Centrin 3
5560:Centrin 2
5555:Centrin 1
4893:Syncoilin
4798:Not alpha
4364:filaments
4316:Fibrillin
2093:Structure
1648:integrins
1634:Vinculin
1564:IPR015009
1491:α-actinin
1479:cytoplasm
1462:integrins
1457:filopodia
1386:α-actinin
1364:Structure
1235:NP_033528
1214:NP_054706
1210:NP_003364
1184:NM_009502
1163:NM_014000
1159:NM_003373
989:Orthologs
838:costamere
743:cytoplasm
599:left lung
517:vena cava
232:GeneCards
5931:Nonhuman
5891:Vinculin
5852:Dystonin
5784:Spectrin
5757:Utrophin
5737:Membrane
5692:Catenins
5624:Stathmin
5612:Dynactin
5492:DYNC2LI1
5487:DYNC1LI2
5482:DYNC1LI1
5147:Kinesins
4951:Tubulins
4840:Vimentin
4372:Type 1/2
4274:Profilin
4269:Gelsolin
4131:Troponin
3692:Proteins
2997:Scanning
2728:Genomics
2684:15494027
2645:22408999
2637:25424202
2615:Model".
2601:10085297
2462:10330411
2282:39567003
2233:15159399
2151:16460027
2115:15242595
1998:11785963
1960:43087259
1917:33153559
1837:–
1816:–
1773:Paxillin
1760:interact
1681:residues
1603:RCSB PDB
1559:InterPro
1417:integrin
1394:paxillin
1328:integrin
1320:vinculin
1283:Wikidata
968:Sources:
853:podosome
763:membrane
575:calvaria
5918:PLEKHA7
5872:Plectin
5837:Plakins
5762:Ankyrin
5661:Dynamin
5591:Spastin
5586:Katanin
5550:CAMSAP3
5545:CAMSAP2
5540:CAMSAP1
5512:DYNLRB2
5507:DYNLRB1
5477:DYNC1I2
5472:DYNC1I1
5467:DYNC2H1
5462:DYNC1H1
5355:Dyneins
5079:TUBGCP6
5074:TUBGCP5
5069:TUBGCP4
5064:TUBGCP3
5059:TUBGCP2
4888:Synemin
4631:type II
4493:type II
4376:Keratin
4321:Filamin
4262:Destrin
4245:Cofilin
4206:Actinin
3777:Myosins
3694:of the
3369:PDBe-KB
3359:UniProt
3348:PDBe-KB
3338:UniProt
3318:9535896
3283:9405455
3248:9054445
3213:8994410
3184:8612698
3155:8610074
3126:8609175
3117:2120789
3083:8440716
3048:8276759
3019:7994488
2984:4369795
2976:7816144
2947:7682697
2902:7566098
2874:7534286
2839:7525621
2814:2503380
2793:2116004
2748:1505973
2719:1339348
2592:2148189
2552:8922390
2543:2133378
2503:9054445
2453:2133183
2413:9535896
2372:9405455
2331:3138246
2322:2115213
2274:8425604
2192:6809764
2071:9056408
2033:9486805
1952:6988083
1839:Ensembl
1818:Ensembl
1685:helical
1674:helices
1650:to the
1644:binding
1552:PF08913
1390:F-actin
1378:proline
1354:catenin
1343:F-actin
1101:UniProt
1056:Ensembl
995:Species
974:QuickGO
753:cytosol
513:urethra
462:pattern
320:10q22.2
188:Aliases
5819:SPTBN5
5814:SPTBN4
5809:SPTBN2
5804:SPTBN1
5794:SPTAN1
5629:Tektin
5522:DYNLT3
5517:DYNLT1
5502:DYNLL2
5497:DYNLL1
5444:DNALI1
5429:DNAH17
5424:DNAH14
5419:DNAH13
5414:DNAH12
5409:DNAH11
5404:DNAH10
5325:KIF26B
5320:KIF26A
5295:KIF21B
5290:KIF21A
5285:KIF20B
5280:KIF20A
5270:KIF18B
5265:KIF18A
5255:KIF16B
5240:KIF13B
5235:KIF13A
5034:TUBB4Q
5019:TUBB2C
5014:TUBB2B
5009:TUBB2A
4989:TUBA4A
4984:TUBA3E
4979:TUBA3D
4974:TUBA3C
4969:TUBA1C
4964:TUBA1B
4959:TUBA1A
4902:Type 5
4861:Nestin
4849:Type 4
4825:Desmin
4818:Type 3
4571:type I
4402:type I
4348:TRIOBP
4014:MYO18B
4009:MYO18A
4005:XVIII
3999:MYO15A
3734:Actins
3364:Q64727
3343:P18206
3316:
3281:
3246:
3211:
3182:
3153:
3124:
3114:
3081:
3046:
3017:
2982:
2974:
2956:Nature
2945:
2935:
2900:
2890:Nature
2872:
2837:
2812:
2791:
2781:
2746:
2717:
2682:
2643:
2635:
2599:
2589:
2550:
2540:
2501:
2460:
2450:
2411:
2370:
2329:
2319:
2280:
2272:
2231:
2190:
2149:
2113:
2069:
2031:
1996:
1958:
1950:
1915:
1909:574428
1907:
1779:SORBS1
1762:with:
1742:, and
1676:. The
1657:. The
1618:PDBsum
1592:
1582:
1538:Symbol
1439:, and
1398:lipids
1396:, and
1269:search
1267:PubMed
1134:Q64727
1115:P18206
1011:Entrez
633:BioGPS
537:nipple
212:193065
5879:Talin
5862:MACF1
5830:Other
5789:SPTA1
5654:TEKT5
5649:TEKT4
5644:TEKT3
5639:TEKT2
5634:TEKT1
5617:DCTN1
5600:Other
5454:DNAL4
5449:DNAL1
5439:DNAI2
5434:DNAI1
5399:DNAH9
5394:DNAH8
5389:DNAH7
5384:DNAH6
5379:DNAH5
5374:DNAH3
5369:DNAH2
5364:DNAH1
5345:KIFC3
5340:KIFC2
5335:KIFC1
5330:KIF27
5315:KIF25
5310:KIF24
5305:KIF23
5300:KIF22
5275:KIF19
5260:KIF17
5250:KIF15
5245:KIF14
5230:KIF12
5225:KIF11
5205:KIF5C
5200:KIF5B
5195:KIF5A
5190:KIF4B
5185:KIF4A
5180:KIF3C
5175:KIF3B
5170:KIF2C
5165:KIF2A
5160:KIF1B
5155:KIF1A
5127:MAP1B
5122:MAP1A
5089:TUBE1
5084:TUBD1
5054:TUBG2
5049:TUBG1
5044:TUBB8
5039:TUBB6
5029:TUBB4
5024:TUBB3
5004:TUBB1
4994:TUBA8
4343:Espin
4304:Other
4291:Titin
4097:Other
4086:MYLL1
4081:MYLK2
4071:MYLIP
4056:MYL6B
3989:MYO10
3979:MYO9B
3974:MYO9A
3964:MYO7B
3959:MYO7A
3939:MYO5C
3934:MYO5B
3929:MYO5A
3919:MYO3B
3914:MYO3A
3904:MYH16
3899:MYH15
3894:MYH14
3889:MYH13
3884:MYH11
3879:MYH10
3864:MYH7B
3823:MYO1H
3818:MYO1G
3813:MYO1F
3808:MYO1E
3803:MYO1D
3798:MYO1C
3793:MYO1B
3788:MYO1A
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